CN105853689A - Application of green plum extract to preparation of health care product for treating osteoporosis - Google Patents
Application of green plum extract to preparation of health care product for treating osteoporosis Download PDFInfo
- Publication number
- CN105853689A CN105853689A CN201610397167.5A CN201610397167A CN105853689A CN 105853689 A CN105853689 A CN 105853689A CN 201610397167 A CN201610397167 A CN 201610397167A CN 105853689 A CN105853689 A CN 105853689A
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- health products
- plum extract
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- fruit
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Classifications
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Abstract
The invention belongs to the field of health care products and relates to application of green plum extract to preparation of a health care product for treating osteoporosis. The health care product is prepared from, by weight, 18-25 parts of green plum extract, 17-24 parts of folium artemisiae argyi, 19-27 parts of rhizoma drynariae, 15-21 parts of herba epimedii, 16-22 parts of achyranthes bidentata, 11-17 parts of fructus ligustri lucidi, 8-14 parts of bulbus allii macrostemonis, 7-15 parts of rhizoma dioscoreae, 7-11 parts of semen sesami nigrum and 6-13 parts of radix glycyrrhizae. It is proved through experimental study on pharmacodynamics that the curative effect on the aspect of health care of osteoporosis is definite, and the effects of enriching the blood and activating the blood, strengthening bones, tonifying the liver and the kidney and strengthening tendons and bones are achieved.
Description
Technical field
The invention belongs to field of health care products, be specifically related to plum extract and dredge at preparation treatment sclerotin
Purposes in pine health products.
Background technology
Osteoporosis i.e. osteoporosis, is one group of osteopathy causing of many reasons.Bone tissue has
Normal calcification, calcium salt and matrix are normal rates, are reduced to unit volume inner bone tissues amount
The metabolic bone disease of feature becomes.In most osteoporosises, the minimizing of bone tissue is mainly due to bone
Matter absorbs and increases caused, with skeleton pain, is prone to fracture and is characterized.Morbidity is the slowest, individually
Comparatively fast, with skeleton pain, being prone to fracture and be characterized, biochemical analysis is normal.Primary bone
The modal symptom of matter osteoporosis, common with lumbago, account for 70% in pain patients～80%.
Pain spreads along backbone to both sides, lies on the back or pain relief during seat, time upright after stretch or for a long time vertical,
During sitting, the pain increased, bends over, coughs, increases the weight of when defecating firmly.
The traditional Chinese medical science thinks that this disease belongs to traditional Chinese medicine " atrophic debility of bones " category, how because of deficiency of kidney essence, decline of kidney-YANG
Can not fill the raw marrow of bone, the deficiency of the kidney yin, essence are become homeless foster, it is impossible to support marrow.Doctor trained in Western medicine is then thought mainly
Bone network Leukopenia is caused to cause owing to forfeiture i.e. calcium ion metabolic function that bone is calcareous goes down
, may occur in which ostalgia during general bone loss more than 12%.
Osteoporosis illness once occurs, treats the most difficult.Treat hyperostosis both at home and abroad at present
Raw disease there is no effective medicine, the traditional Chinese medical science mainly with filling liver kidney, wines used as antirheumatic, swelling and pain relieving,
It is main for relaxing the muscles and stimulate the blood circulation, and is aided with existing Chinese herbal medicine and treats.Massage and drawing method are outer power
Effect, only treat but to ignore to local and integrally regulate in human body, therefore, only
Temporary transient analgesic effect can be played, and the purpose for the treatment of can not be reached.Acupuncture method can restore menstrual flow and invigorate blood circulation
And have analgesic effect, pain can be eliminated, but acupuncture can only help out for osteoporosis.
This disease of western medical treatment relies primarily on drug therapy, generallys include HRT, fall calcium
Element and calcium preparation etc..Curative effect is relief of symptoms, takes stopgap measures and does not effects a permanent cure, and the state of an illness easily recurs, and
These medicines are the most expensive, and have more significantly side effect, and the life to patient causes
The biggest impact.Therefore, focus on strengthening sclerotin nutrition at ordinary times to be extremely necessary, for daily bone
Matter is poor or for some reason, and the crowd that osteoporosis incidence is higher takes and contributes to
The health products strengthening sclerotin can effectively reduce the possibility suffering from bone loss disorders.
Therefore it is crucial for selecting regular, effective, not have side effect health products, and external traditional Chinese medicinal application is protected
The advantage of strong sclerotin maximum is to carry out the most effective maintenance.According to traditional Chinese medical science canon Huangdi's Internal Classics
Recording, in tradition doctor's strange method of bone, maximally efficient means are that the normal temperature in water-soluble transdermal art dresses treatment
Method, is commonly called as " poultice ", reconciles into pasty state with watery wine etc. after referring to pulverize high-quality Chinese medicine preparation,
Apply a kind of transdermal methods carrying out treating in local.Feature is not heat, and dose is big, dissociates.
Gu has saying of " sticking with paste gas hundred cream ", has penetration by force, absorbs the features such as fast.
Chinese patent application CN102988607A discloses a kind of health care for osteoporosis
Chinese medicine composition, by cultivated land, the bark of eucommia, Chinese yam, the fruit of Chinese wolfberry, the seed of Chinese dodder, Radix Angelicae Sinensis, frutus cnidii,
Psoralea corylifolia, astragalus root, that certain weight ratio pressed by deer horn glue is formulated, this health-care Chinese medicinal composition
In keeping healthy for osteoporosis, there is obvious effect, alleviate symptom, play a role in health care,
But wherein deer horn glue is on the high side, composition preparation cost is higher, and deer horn glue is suitable for crowd
Narrower, the people of interior heat cannot eat.
Summary of the invention
For solving the deficiencies in the prior art, it is an object of the invention to provide plum extract
Purposes in preparation treatment osteoporosis health products.
For realizing the purpose of the present invention, the research of the present inventor's foundation theory of traditional Chinese medical science and clinic are repeatedly
Test and checking, it is provided that plum extract preparation treatment osteoporosis health products in use
On the way, the raw material of preparing of described health products includes the component of following weight portion:
Plum extract 18-25 part, tarragon 17-24 part, rhizome of davallia 19-27 part, barrenwort
15-21 part, radix achyranthis bidentatae 16-22 part, fruit of glossy privet 11-17 part, Longstamen Onion Bulb 8-14 part, Chinese yam
7-15 part, Semen sesami nigrum 7-11 part and Radix Glycyrrhizae 6-13 part.
Preferably, the raw material of preparing of described health products includes the component of following weight portion:
Plum extract 18 parts, tarragon 17 parts, the rhizome of davallia 19 parts, barrenwort 15 parts, bosom
The root of bidentate achyranthes 16 parts, the fruit of glossy privet 11 parts, Longstamen Onion Bulb 8 parts, Chinese yam 7 parts, Semen sesami nigrum 7 parts and Radix Glycyrrhizae
6 parts.
Preferably, the raw material of preparing of described health products includes the component of following weight portion:
Plum extract 21 parts, tarragon 20 parts, the rhizome of davallia 23 parts, barrenwort 18 parts, bosom
The root of bidentate achyranthes 19 parts, the fruit of glossy privet 14 parts, Longstamen Onion Bulb 11 parts, Chinese yam 11 parts, Semen sesami nigrum 9 parts and sweet
Grass 8 parts.
Preferably, the raw material of preparing of described health products includes the component of following weight portion:
Plum extract 25 parts, tarragon 24 parts, the rhizome of davallia 27 parts, barrenwort 21 parts, bosom
The root of bidentate achyranthes 22 parts, the fruit of glossy privet 17 parts, Longstamen Onion Bulb 14 parts, Chinese yam 15 parts, Semen sesami nigrum 11 parts and
13 parts of Radix Glycyrrhizae.
According to the compatibility theory of the dialectical and Chinese medicine of osteoproliferation health products, study the science in conjunction with health
Opinion knowledge and the fitness feature of modern, the collocation ingredients of reasonable science, assist comprehensively
Ground conditioning engine body is adjusted to form health products of the present invention.In the present invention, plum extract, tarragon and bone are broken
Mend kidney-replenishing, strengthening the bones and muscles；Barrenwort, radix achyranthis bidentatae and fruit of glossy privet boosting qi and nourishing yin, tonifying speen and tonifying kidney；
Longstamen Onion Bulb, Chinese yam and Semen sesami nigrum are activated yang and removed abstruction；Radix Glycyrrhizae is invigorated blood circulation and stimulates the menstrual flow, coordinating the drug actions of a prescription；Each component phase
Coordinate mutually, collaborative promote, complement each other, be finally reached replenishing and activating blood, strong bone, filling liver kidney,
Dredge effect of muscles and bones.
The preparation method of health products of the present invention is as follows:
A) taking the green plum of maturity uniformity, stoning, breaking into particle diameter with tissue mashing machine is
The puree of 1～4mm, with the ethanol solution that volume fraction is 70-90% by the feed liquid of l:3-5
Ratio mechanical shaking extraction 2-3 time at 50-60 DEG C, each 4-6h, filter, merging filtrate,
Obtain syrupy shape brown thing through vacuum evaporation at 40-50 DEG C, be plum extract；
B) weigh tarragon, the rhizome of davallia, barrenwort, radix achyranthis bidentatae, the fruit of glossy privet, Longstamen Onion Bulb, Chinese yam,
Semen sesami nigrum and Radix Glycyrrhizae, clean respectively, decontamination, standby after being ground into meal；
C) toward the distilled water of addition 7-11 times of weight of meal in above-mentioned meal, 12-24 is soaked little
Time, decoct 3-4 time, each 1-3 hour, filter, merging filtrate, be evaporated to 50-60 DEG C
Lower relative density is that the concentrate of 1.25-1.30 is standby；
D) by step A) gained plum extract and step C) gained concentrate merges, mixing
Uniformly, drying under reduced pressure obtains medicinal extract, is pulverized by medicinal extract, grinds, and crosses 100-120 mesh sieve, in obtaining
Medicine fine powder, adds auxiliary material, makes health products finished product.
Preferably, described health products be made into tablet, capsule, granule, pill, powder,
Supensoid agent, paste or oral liquid.
Preferably, described step D) described in auxiliary material selected from starch, dextrin, sucrose, milk powder,
Sweetener, mannitol, lactose, cellulose family and derivative thereof, calcium carbonate, cyclodextrin,
One or more in beta-schardinger dextrin, phospholipid material, magnesium stearate, talcum powder and essence.
Health products of the present invention, come from China's health theory and the achievement in research of modern pharmacology, warp
Cross pharmacodynamic experiment research, it was demonstrated that it loosens aspect determined curative effect at health care bone.The present invention protects
Strong product have replenishing and activating blood, effect of muscles and bones is dredged in strong bone, filling liver kidney, and health products of the present invention are comprehensive
Conditioning engine body in phase, medication is simple and convenient, without any side effects.
Detailed description of the invention
Further describing the present invention below by way of specific embodiment, the present invention is not limited only to following
Embodiment.Within the scope of the invention or without departing from present disclosure, spirit and scope
In, change that the present invention is carried out, combine or replace, for a person skilled in the art
It is apparent from, is included within the scope of the present invention.
Embodiment l
The embodiment of the present invention 1 health products are prepared from by the raw material of following parts by weight:
Plum extract 18 parts, tarragon 17 parts, the rhizome of davallia 19 parts, barrenwort 15 parts, bosom
The root of bidentate achyranthes 16 parts, the fruit of glossy privet 11 parts, Longstamen Onion Bulb 8 parts, Chinese yam 7 parts, Semen sesami nigrum 7 parts and Radix Glycyrrhizae
6 parts.
Preparation method:
A) taking the green plum of maturity uniformity, stoning, breaking into particle diameter with tissue mashing machine is
The puree of 2mm, with the ethanol solution that volume fraction is 80% by the solid-liquid ratio of l:4 at 55 DEG C
Lower mechanical shaking extraction 2 times, each 5h, filters, merging filtrate, through vacuum evaporation at 45 DEG C
It is concentrated to give syrupy shape brown thing, is plum extract；
B) weigh tarragon, the rhizome of davallia, barrenwort, radix achyranthis bidentatae, the fruit of glossy privet, Longstamen Onion Bulb, Chinese yam,
Semen sesami nigrum and Radix Glycyrrhizae, clean respectively, decontamination, standby after being ground into meal；
C) toward the distilled water of addition 9 times of weight of meal in above-mentioned meal, soak 24 hours, decoct
Boil 3 times, each 2 hours, filter, merging filtrate, be evaporated at 55 DEG C the closeest
Degree be 1.25 concentrate standby；
D) by step A) gained plum extract and step C) gained concentrate merges, mixing
Uniformly, drying under reduced pressure obtains medicinal extract, is pulverized by medicinal extract, grinds, and crosses 100 mesh sieves, obtains Chinese medicine thin
Powder, adds auxiliary material, makes granule.
Embodiment 2
The embodiment of the present invention 2 health products are prepared from by the raw material of following parts by weight:
Plum extract 21 parts, tarragon 20 parts, the rhizome of davallia 23 parts, barrenwort 18 parts, bosom
The root of bidentate achyranthes 19 parts, the fruit of glossy privet 14 parts, Longstamen Onion Bulb 11 parts, Chinese yam 11 parts, Semen sesami nigrum 9 parts and sweet
Grass 8 parts.
Preparation method reference example 1.
Embodiment 3
The embodiment of the present invention 3 health products are prepared from by the raw material of following parts by weight:
Plum extract 25 parts, tarragon 24 parts, the rhizome of davallia 27 parts, barrenwort 21 parts, bosom
The root of bidentate achyranthes 22 parts, the fruit of glossy privet 17 parts, Longstamen Onion Bulb 14 parts, Chinese yam 15 parts, Semen sesami nigrum 11 parts and
13 parts of Radix Glycyrrhizae.
Preparation method reference example 1.
Embodiment 4
The embodiment of the present invention 4 health products are prepared from by the raw material of following parts by weight:
Plum extract 19 parts, tarragon 18 parts, the rhizome of davallia 20 parts, barrenwort 16 parts, bosom
The root of bidentate achyranthes 17 parts, the fruit of glossy privet 12 parts, Longstamen Onion Bulb 9 parts, Chinese yam 8 parts, Semen sesami nigrum 8 parts and Radix Glycyrrhizae
7 parts.
Preparation method reference example 1.
Embodiment 5
The embodiment of the present invention 5 health products are prepared from by the raw material of following parts by weight:
Plum extract 24 parts, tarragon 23 parts, the rhizome of davallia 26 parts, barrenwort 20 parts, bosom
The root of bidentate achyranthes 21 parts, the fruit of glossy privet 16 parts, Longstamen Onion Bulb 13 parts, Chinese yam 14 parts, Semen sesami nigrum 10 parts and
12 parts of Radix Glycyrrhizae.
Preparation method reference example 1.
Comparative example 1
Health products described in comparative example 1 of the present invention are prepared from by the raw material of following parts by weight:
Plum extract 21 parts, tarragon 20 parts, the rhizome of davallia 23 parts, barrenwort 18 parts, bosom
The root of bidentate achyranthes 19 parts, the fruit of glossy privet 14 parts, Longstamen Onion Bulb 11 parts, Chinese yam 15 parts and 13 parts of Radix Glycyrrhizae.
Preparation method reference example 2.
Comparative example 1 is with the difference of embodiment 2, eliminates Semen sesami nigrum, adds Radix Glycyrrhizae
Parts by weight with Chinese yam.
Comparative example 2
Health products described in comparative example 2 of the present invention are prepared from by the raw material of following parts by weight:
Plum extract 21 parts, tarragon 20 parts, the rhizome of davallia 23 parts, barrenwort 18 parts, bosom
The root of bidentate achyranthes 19 parts, the fruit of glossy privet 14 parts, Longstamen Onion Bulb 11 parts, Chinese yam 11 parts, Semen sesami nigrum 9 parts and sweet
Grass 8 parts.
Repeat embodiment 2 preparation method by identical step, but step A) in plum extract
It is 1:5 with the proportioning of ethanol solution.
Comparative example 2 is with the difference of embodiment 2, changes plum extract and ethanol solution
Proportioning.
Test example one, the health products of the present invention test to osteoporosis rat experimental model
1, experimental animal: SPF level female sd inbred rats 120, body weight 220 ± 20g, with
Machine is divided into 12 groups, often group 10.
2, modeling: take above-mentioned 12 groups of rats, use 3.5% chloraldurate, 0.1mLlOg-1 body
Weight intraperitoneal injection of anesthesia, with the total bone density scan in DPX type Dual-energy X-rays absorptionmetry row basis
And record its bone density value respectively.Take wherein 11 groups of rats underwent Bilateral oophorectomy operations at random.
Detailed process is as follows: lying on the back on operating table by postanesthetic rat, four limbs are fixed, and belly is just
In place on the lower side preserved skin, alcohol disinfecting, cut skin, cut muscle successively in hunter's line, cut off abdomen
Film enters abdominal cavity, it is seen that milky tissue.Gently by proposition abdominal cavity, i.e. visible wrapped
Pink mung bean size " mulberry fruit sample " ovary, clamp, ligation after separation, cut off ovary, inspection
Looking into or without oozing of blood, be layered skin suture, alcohol otch is sterilized.Treat recovery from anesthesia.Take remaining one
Group rat makees sham-operation, after being taken out by ovary, is left intact and puts back to abdominal cavity, sewing-up cut,
Sterilization.Postoperative lumbar injection penicillin 40,000 U/, for three days on end, in case infecting.Animal
Extract after ovary 5 days, by only carrying out vagina epithelium angling inspection, every day 1 time, continuous 5 days,
Observe the change of vagina epithelium keratinocyte aperiodicity.After modeling January, with DPX type dual intensity
X-ray borne densitometers is to all rats underwent total bone density scan of live body whole body, and rat bone density value is relatively
Before modeling decline more than 10%, with prove modeling success, by above-mentioned determine operation modeling success after
11 groups of rats and another set rat normally raise 3 months.
3, it is grouped and is administered
Above-mentioned 11 groups of rats are respectively labeled as Osteoporotic Model group, positive controls (bone
The precious particle of pine), A group (granule high dose group (900mg/kg) that the embodiment of the present invention 1 prepares,
Middle dosage group (600mg/kg), low dose group (300mg/kg)), B group (present invention implement
Granule high dose group (900mg/kg) that example 2 prepares, middle dosage group (600mg/kg), low
Dosage group (300mg/kg)) and (the granule height agent that the embodiment of the present invention 3 prepares of C group
Amount group (900mg/kg), middle dosage group (600mg/kg), low dose group (300mg/kg))；
Sham-operation group, model group rats gavage every day give the beta-schardinger dextrin that concentration is 1.33%
The aqueous solution；
Positive controls: positive control drug is bone pine treasured particle (200mg/kg) (the quasi-word of traditional Chinese medicines
Z52020006, Fuhua Pharmaceutical LLC, Guizhou)；
Below respectively gastric infusion every day is organized 1 time, successive administration 3 months.
4, test:
Administration terminates rear sacrificed by decapitation animal, takes rats with bilateral femur and peels meat and hetero-organization thereof off,
Wherein side femur does bone density scan on Dual-energy X-rays absorptionmetry, measures bone density
(g/cm2), face upward left femur to be placed on poly (methyl methacrylate) plate and be scanned, step pitch 0.5 ×
0.5mm；Sweep speed 30mm/s；Sweep length 6.55cm.After bone densitometry terminates,
Will femur-40 DEG C preservation, send survey biomechanics of bone intensity.Claim femur weight (W), survey bone length (L),
Dry 1 hour, then put 200 DEG C, 400 DEG C, 600 DEG C, 800 DEG C of each ashes in Muffle furnace for 110 DEG C
Changing two hours, ashing terminates, and cooling claims ash weight (Wash), after extracting with the HNO3 of 6N
Survey bone ash Ca content, represent with the grams of 100g bone ash calcium ions.
Result of the test all represents with mean+SD (X ± SD), compares employing SAS between group
Statistical software generalized linear model carries out the analysis of covariance, has aobvious as difference using p ＜ 0.05
The standard of work property.N is rat number.
5, result of the test: as shown in table 1,2.
The impact on rat femur density of table 1 medicine
Note: compare with sham-operation group,#P ＜ 0.05,##P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01；Compare with positive controls,^P < 0.05,^^P<0.01。
From upper table result, model control group compares with sham-operation group, and bone density value substantially drops
Low (P ＜ 0.01), it was demonstrated that modeling success.Each experimental group compares with model control group, bone density value
Significantly raised, there is significant difference.Compared with positive controls, A, B, C of the present invention
Group all can significantly raised rat femur density.
The impact on rat femur calcium content of bone of table 2 medicine
Note: compare with sham-operation group,#P ＜ 0.05,##P ＜ 0.01；Compare with model group,*P ＜ 0.05,**P ＜ 0.01；Compare with positive controls,^P < 0.05,^^P<0.01。
From upper table result, model control group compares with sham-operation group, and rat femur bone calcium contains
Amount substantially reduction has pole significant difference (P ＜ 0.01), it was demonstrated that modeling success.Each experimental group with
Model control group compares, rat femur calcium content of bone significantly raised (P ＜ 0.01).Right with the positive
Comparing according to group, A, B, C group of the present invention all can significantly raised rat femur calcium content of bone.
6, conclusion (of pressure testing):
Test data shows, health products of the present invention can be effectively increased castration osteoporosis model rat
Bone density and the content of femur bone calcium.In the present invention, (i.e. the present invention is real for experimental administration A group
Execute the pharmaceutical composition that example 1 prepares) basic, normal, high dosage group, health products B group of the present invention
(pharmaceutical composition of the present invention that i.e. embodiment of the present invention 2 prepares) basic, normal, high dosage group and
Health products C group of the present invention (pharmaceutical composition of the present invention that i.e. embodiment of the present invention 3 prepares)
Basic, normal, high dosage group experiment effect is obvious, health products B group the most of the present invention (i.e. this
The health products of the present invention that bright embodiment 2 prepares) high dose group best results, for treatment sclerotin
Loose have significant therapeutic effect.
Claims (8)
1. plum extract purposes in preparation treatment osteoporosis health products, its feature exists
Raw material of preparing in, described health products includes the component of following weight portion:
Plum extract 18-25 part, tarragon 17-24 part, rhizome of davallia 19-27 part, barrenwort
15-21 part, radix achyranthis bidentatae 16-22 part, fruit of glossy privet 11-17 part, Longstamen Onion Bulb 8-14 part, Chinese yam
7-15 part, Semen sesami nigrum 7-11 part and Radix Glycyrrhizae 6-13 part.
2. purposes as claimed in claim 1, it is characterised in that the preparation of described health products
Raw material includes the component of following weight portion:
Plum extract 18 parts, tarragon 17 parts, the rhizome of davallia 19 parts, barrenwort 15 parts, bosom
The root of bidentate achyranthes 16 parts, the fruit of glossy privet 11 parts, Longstamen Onion Bulb 8 parts, Chinese yam 7 parts, Semen sesami nigrum 7 parts and Radix Glycyrrhizae
6 parts.
3. purposes as claimed in claim 1, it is characterised in that the preparation of described health products
Raw material includes the component of following weight portion:
Plum extract 21 parts, tarragon 20 parts, the rhizome of davallia 23 parts, barrenwort 18 parts, bosom
The root of bidentate achyranthes 19 parts, the fruit of glossy privet 14 parts, Longstamen Onion Bulb 11 parts, Chinese yam 11 parts, Semen sesami nigrum 9 parts and sweet
Grass 8 parts.
4. purposes as claimed in claim 1, it is characterised in that the preparation of described health products
Raw material includes the component of following weight portion:
Plum extract 25 parts, tarragon 24 parts, the rhizome of davallia 27 parts, barrenwort 21 parts, bosom
The root of bidentate achyranthes 22 parts, the fruit of glossy privet 17 parts, Longstamen Onion Bulb 14 parts, Chinese yam 15 parts, Semen sesami nigrum 11 parts and
13 parts of Radix Glycyrrhizae.
5. the purposes as described in claim 1-4 is arbitrary, it is characterised in that described health care
Product are prepared by following steps:
A) taking the green plum of maturity uniformity, stoning, breaking into particle diameter with tissue mashing machine is
The puree of 1～4mm, exists by the solid-liquid ratio of l:3-5 with the ethanol that volume fraction is 70-90%
Mechanical shaking extraction 2-3 time at 50-60 DEG C, each 4-6h, filter, merging filtrate, at 40-50 DEG C
Lower obtain syrupy shape brown thing through vacuum evaporation, be plum extract；
B) weigh tarragon, the rhizome of davallia, barrenwort, radix achyranthis bidentatae, the fruit of glossy privet, Longstamen Onion Bulb, Chinese yam,
Semen sesami nigrum and Radix Glycyrrhizae, clean respectively, decontamination, standby after being ground into meal；
C) toward the distilled water of addition 7-11 times of weight of meal in above-mentioned meal, 12-24 is soaked little
Time, decoct 3-4 time, each 1-3 hour, filter, merging filtrate, be evaporated to 50-60 DEG C
Lower relative density is that the concentrate of 1.25-1.30 is standby；
D) by step A) gained plum extract and step C) gained concentrate merges, mixing
Uniformly, drying under reduced pressure obtains medicinal extract, is pulverized by medicinal extract, grinds, and crosses 100-120 mesh sieve, in obtaining
Medicine fine powder, adds auxiliary material, makes health products finished product.
6. the purposes as described in claim 1-4 is arbitrary, it is characterised in that described health products
It is made into tablet, capsule, granule, pill, powder, supensoid agent, paste or oral liquid.
7. purposes as claimed in claim 5, it is characterised in that described step D) described in
Auxiliary material is selected from starch, dextrin, sucrose, milk powder, sweetener, mannitol, lactose, fiber
Element class and derivative, calcium carbonate, cyclodextrin, beta-schardinger dextrin, phospholipid material, tristearin
One or more in acid magnesium, talcum powder and essence.
8. the preparation method of health products as described in claim 1-7 is arbitrary, it is characterised in that
Comprise the following steps:
A) taking the green plum of maturity uniformity, stoning, breaking into particle diameter with tissue mashing machine is
The puree of 1～4mm, with the ethanol solution that volume fraction is 70-90% by the feed liquid of l:3-5
Ratio mechanical shaking extraction 2-3 time at 50-60 DEG C, each 4-6h, filter, merging filtrate,
Obtain syrupy shape brown thing through vacuum evaporation at 40-50 DEG C, be plum extract；
B) weigh tarragon, the rhizome of davallia, barrenwort, radix achyranthis bidentatae, the fruit of glossy privet, Longstamen Onion Bulb, Chinese yam,
Semen sesami nigrum and Radix Glycyrrhizae, clean respectively, decontamination, standby after being ground into meal；
C) toward the distilled water of addition 7-11 times of weight of meal in above-mentioned meal, 12-24 is soaked little
Time, decoct 3-4 time, each 1-3 hour, filter, merging filtrate, be evaporated to 50-60 DEG C
Lower relative density is that the concentrate of 1.25-1.30 is standby；
D) by step A) gained plum extract and step C) gained concentrate merges, mixing
Uniformly, drying under reduced pressure obtains medicinal extract, is pulverized by medicinal extract, grinds, and crosses 100-120 mesh sieve, in obtaining
Medicine fine powder, adds auxiliary material, makes health products finished product.
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| CN201610397167.5A CN105853689A (en) | 2016-06-06 | 2016-06-06 | Application of green plum extract to preparation of health care product for treating osteoporosis |
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|---|---|---|---|
| CN201610397167.5A CN105853689A (en) | 2016-06-06 | 2016-06-06 | Application of green plum extract to preparation of health care product for treating osteoporosis |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107213083A (en) * | 2017-05-25 | 2017-09-29 | 漳浦彩露华化妆品有限公司 | A kind of green plum pole profit MASQUE APAISANT HYDRATANT and preparation method thereof |
| CN107495349A (en) * | 2017-09-29 | 2017-12-22 | 武汉华士特工业生物技术开发有限公司 | A kind of functional food composition of increase bone density containing maca and green plum and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN107213083B (en) * | 2017-05-25 | 2020-07-31 | 漳浦彩露华化妆品有限公司 | Green plum extremely-moistening and moisturizing mask and preparation method thereof |
| CN107495349A (en) * | 2017-09-29 | 2017-12-22 | 武汉华士特工业生物技术开发有限公司 | A kind of functional food composition of increase bone density containing maca and green plum and preparation method thereof |
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