CN1057921C - Oral capsule Xianglianzi for contraception made of traditional Chinese medicine - Google Patents
Oral capsule Xianglianzi for contraception made of traditional Chinese medicine Download PDFInfo
- Publication number
- CN1057921C CN1057921C CN95118955A CN95118955A CN1057921C CN 1057921 C CN1057921 C CN 1057921C CN 95118955 A CN95118955 A CN 95118955A CN 95118955 A CN95118955 A CN 95118955A CN 1057921 C CN1057921 C CN 1057921C
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- China
- Prior art keywords
- contraception
- oral capsule
- chinese medicine
- radix
- traditional chinese
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- 239000003814 drug Substances 0.000 title claims abstract description 31
- 229940100691 oral capsule Drugs 0.000 title claims abstract description 15
- 241000746375 Andrographis Species 0.000 claims description 7
- 235000012343 cottonseed oil Nutrition 0.000 claims description 7
- 210000000582 semen Anatomy 0.000 claims description 7
- 241000241550 Cyathula Species 0.000 abstract description 4
- 241001446509 Psoralea Species 0.000 abstract description 4
- 230000035935 pregnancy Effects 0.000 abstract description 4
- 238000002360 preparation method Methods 0.000 abstract description 2
- 230000001850 reproductive effect Effects 0.000 abstract 2
- 244000144730 Amygdalus persica Species 0.000 abstract 1
- 244000118350 Andrographis paniculata Species 0.000 abstract 1
- 241000544270 Angelica acutiloba Species 0.000 abstract 1
- 241000130781 Arnebia Species 0.000 abstract 1
- 235000014375 Curcuma Nutrition 0.000 abstract 1
- 244000164480 Curcuma aromatica Species 0.000 abstract 1
- 241000612166 Lysimachia Species 0.000 abstract 1
- 240000002853 Nelumbo nucifera Species 0.000 abstract 1
- 235000006508 Nelumbo nucifera Nutrition 0.000 abstract 1
- 235000006510 Nelumbo pentapetala Nutrition 0.000 abstract 1
- 235000006040 Prunus persica var persica Nutrition 0.000 abstract 1
- 244000250129 Trigonella foenum graecum Species 0.000 abstract 1
- 235000001484 Trigonella foenum graecum Nutrition 0.000 abstract 1
- VFLDPWHFBUODDF-FCXRPNKRSA-N curcumin Chemical compound C1=C(O)C(OC)=CC(\C=C\C(=O)CC(=O)\C=C\C=2C=C(OC)C(O)=CC=2)=C1 VFLDPWHFBUODDF-FCXRPNKRSA-N 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 231100000957 no side effect Toxicity 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
- 235000001019 trigonella foenum-graecum Nutrition 0.000 abstract 1
- 239000003433 contraceptive agent Substances 0.000 description 9
- 230000002254 contraceptive effect Effects 0.000 description 7
- 230000000694 effects Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000005303 weighing Methods 0.000 description 5
- 241000699670 Mus sp. Species 0.000 description 4
- 239000002775 capsule Substances 0.000 description 4
- 230000003203 everyday effect Effects 0.000 description 4
- 230000002175 menstrual effect Effects 0.000 description 4
- 238000007789 sealing Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 229940124558 contraceptive agent Drugs 0.000 description 3
- 238000012377 drug delivery Methods 0.000 description 3
- 239000012467 final product Substances 0.000 description 3
- 230000007059 acute toxicity Effects 0.000 description 2
- 231100000403 acute toxicity Toxicity 0.000 description 2
- 230000002158 anti-implantation Effects 0.000 description 2
- 229940126678 chinese medicines Drugs 0.000 description 2
- 239000000796 flavoring agent Substances 0.000 description 2
- 235000019634 flavors Nutrition 0.000 description 2
- 210000002784 stomach Anatomy 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 241000892865 Heros Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000013011 mating Effects 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 229940127234 oral contraceptive Drugs 0.000 description 1
- 239000003539 oral contraceptive agent Substances 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229940023488 pill Drugs 0.000 description 1
- 239000006187 pill Substances 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 239000003270 steroid hormone Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
Abstract
The present invention relates to a Xianglianzi oral capsule as a pure traditional Chinese medical preparation for the contraception of women in reproductive age. The oral capsule is prepared from twelve kinds of pure traditional Chinese medicine: fenugreek lysimachia, soft kernel, herba spirodelae, peach kernel, southern curcuma, green chiretta, arnebia root, psoralea fruit, whole tangkuei, chuanxiong rhizome, cyathula root, snow lotus, etc. The twelve kinds of traditional Chinese medicine are weighed according to a certain proportion, jointly ground into fine powder and encapsulated. Through 301 cases of clinical application of women in reproductive age, the total effective rate can reach 98%, and the purpose for preventing nidation and early pregnancy can be achieved. The oral capsule has the advantages of safe and reliable use, low price and no side effect.
Description
The present invention relates to the pure Chinese medicinal preparation that childbearing age woman contraceptive is used
China is a populous nation, practicing family planning is the fundamental state policy of China, in family planning work in the past, use steroid hormone class medicine to carry out contraceptives to the women of child-bearing age always, for example put intrauterine device, oral contraceptive, external contraceptive cover etc.In secular observation, find, adopt existing contraceptives can produce in various degree side effect human body.Particularly some is suffered from other disease and can not adopt existing contraceptives person very painful.Therefore, seek the new way of Chinese medicine contraception, become the task of top priority of medical circle.The present invention develops the Chinese medicine oral capsule Xianglianzi for contraception made of satisfactory effect groping and test through secular.
The object of the invention is, the Chinese medicine oral capsule Xianglianzi for contraception made of development is to have adopted 12 flavor Chinese medicines to make, through the 301 routine women of child-bearing age being taken clinical observation and following up a case by regular visits to, 200 examples in 25-30 year wherein, 101 examples in 36-40 year, total contraceptive rate is not all found any toxic and side effects more than 98%, this medicine taking convenience, safe and reliable, cheap, be the desirable medicine that pure Chinese medicine contraception is used in present family planning.
Task of the present invention is, the Chinese medicine oral capsule Xianglianzi for contraception made of development, 12 flavor Chinese medicines are distinguished pulverization in proportion, incapsulate, every capsules 0.4 gram, taking method, first day (or full back first day of term) after every menstrual phase begins to take medicine, and serve on three, every day three times, each 2 grams, early, middle and late boiled water takes the purpose that can reach of that month contraception.
Chinese medicine oral capsule Xianglianzi for contraception made of the present invention, it mainly is made up of Herba Lysimachiae foenum-graeci, Cottonseed, Herba Spirodelae, Semen Persicae, RADIX CURCUMAE, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae, Herba Saussureae Involueratae, and its each medicine compatibility is: Herba Lysimachiae foenum-graeci 15-25 part, Cottonseed 10-20 part, Herba Spirodelae 5-15 part, Semen Persicae 5-15 part, RADIX CURCUMAE, 5-15 part, Herba Andrographis 5-15 part, Radix Arnebiae (Radix Lithospermi) 5-15 part, Fructus Psoraleae 5-15 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 5-12 part, Radix Cyathulae 5-12 part, Herba Saussureae Involueratae 1-10 part.Its method for production is: Herba Lysimachiae foenum-graeci, Cottonseed, Herba Spirodelae, Semen Persicae, RADIX CURCUMAE, Herba Andrographis, Radix Arnebiae (Radix Lithospermi), Fructus Psoraleae, Radix Angelicae Sinensis, Rhizoma Chuanxiong, Radix Cyathulae, Herba Saussureae Involueratae are ground smalls respectively in proportion jointly, incapsulate, the vial sealing.
Chinese medicine oral capsule Xianglianzi for contraception made of the present invention, through the 301 routine women of child-bearing age are taken, wherein adhering to taking medicine in every month reaches 1 year person 175 people, responder 172 people that practise contraception, nonresponder 3 people.2 years person 100 people that adhere to taking medicine, contraception responder 98 people, nonresponder 2 people.3 years person 26 people that adhere to taking medicine, contraception responder 25 people, nonresponder 1 people, total effective rate 98%.To 301 routine women of child-bearing age pill taker long-term observation and following up a case by regular visits to, do not find any toxic and side effects, and reach anti-implantation simultaneously, the effect of antiearly pregnancy, and can keep women 's life, physiological function normal at period in a medicine.
Chinese medicine oral capsule Xianglianzi for contraception made of the present invention shows through the acute toxicity prediction experiment (L050) of animal and the trial test result of contraceptive pharmacy
1, the acute toxicity trial test (L050) of Xianglianzi oral capsule
Take by weighing 10 of 10-20g NIH healthy mices, male and female half and half are divided into five groups of A, B, C, D, E, respectively dose are made into
A group dose is that 121mg/ B group dose is 84.7mg/ time
C group dose is that 60.5mg/ D group dose is 36.3mg/ time
E group dose is 12.1mg/ time
Mice is irritated stomach through fasting, taboo water after 2 hours, observe a week, see Table 1
| Group | Number of animals (only) | Death toll (only) |
| A B C D E | 2 2 2 2 2 | —— —— —— —— |
2, the trial test of Xianglianzi oral capsule contraceptive pharmacodynamics
Take by weighing 10 of the healthy male and female mices of 25-28g and be divided into five groups of A, B, C, D, E, make up a prescription respectively into:
A group 3.8mg/ml B group 3mg/ml
C group 2.4mg/ml D group 2mg/ml
E organizes 1.6mg/ml
To mice fasting water after 2 hours, to irritate stomach and took medicine continuously 5 days, administration volume 0.5ml/ Mus is after mating 7 days entirely by female two heros in second day that stops, and anatomic observation gestation situation sees Table 2
| Group | Number of animals (only) | Death toll (only) |
| A B C D E | 2 2 2 2 2 | —— —— —— —— —— |
As can be seen from Table 1, this poison of drug of Xianglianzi 1050 trial tests is less, and Xianglianzi plays the effect of contraception in the Chinese medicine contraceptive as can be seen from Table 2, so Chinese medicine oral capsule Xianglianzi for contraception made of the present invention, the mutual compatibility of medicine, the property of medicine is coordinated, and cold and heat help mutually, through-supplementation, promptly abide by the style of ancient matter modelled after an antique, meet the principle of Modern Pharmaceutical Chemistry again, can reach contraception and not hinder healthy energy, set upright and do not hinder contraceptive effect, thereby have the good action of anti-implantation, antiearly pregnancy.
Embodiment 1:
It is even to take by weighing 15 parts of Herba Lysimachiae foenum-graeci, 20 parts of Cottonseed, 10 parts of Herba Spirodelae, 5 parts in Semen Persicae, 15 parts of RADIX CURCUMAEs, 15 parts of Herba Andrographis, 10 parts of Radix Arnebiae (Radix Lithospermi)s, 5 parts of Fructus Psoraleaes, 5 parts of Radix Angelicae Sinensis, 10 parts of Rhizoma Chuanxiongs, 12 parts of Radix Cyathulaes, 5 parts of mixed together of Herba Saussureae Involueratae, grind smalls, incapsulate, every capsules 0.4 gram, the vial sealing gets final product, and every menstrual phase is use up back first day (or term is completely back) and is begun to take medicine, serve on three, every day three times, each 2 grams, boiled water drug delivery.
Embodiment 2
It is even to take by weighing 25 parts of Herba Lysimachiae foenum-graeci, 10 parts of Cottonseed, 5 parts of Herba Spirodelae, 10 parts in Semen Persicae, 10 parts of RADIX CURCUMAEs, 5 parts of Herba Andrographis, 15 parts of Radix Arnebiae (Radix Lithospermi)s, 10 parts of Fructus Psoraleaes, 10 parts of Radix Angelicae Sinensis, 5 parts of Rhizoma Chuanxiongs, 10 parts of Radix Cyathulaes, 3 parts of mixed together of Herba Saussureae Involueratae, grind smalls, incapsulate, every capsules 0.4 gram, the vial sealing gets final product, and every menstrual phase is use up back first day (or term is completely back) and is begun to take medicine, serve on three, every day three times, each 2 grams, boiled water drug delivery.
Embodiment 3:
It is even to take by weighing 20 parts of Herba Lysimachiae foenum-graeci, 15 parts of Cottonseed, 15 parts of Herba Spirodelae, 15 parts in Semen Persicae, 5 parts of RADIX CURCUMAEs, 10 parts of Herba Andrographis, 5 parts of Radix Arnebiae (Radix Lithospermi)s, 15 parts of Fructus Psoraleaes, 15 parts of Radix Angelicae Sinensis, 12 parts of Rhizoma Chuanxiongs, 5 parts of Radix Cyathulaes, 10 parts of mixed together of Herba Saussureae Involueratae, grind smalls, incapsulate, every capsules 0.4 gram, the vial sealing gets final product, and every menstrual phase is use up back first day (or term is completely back) and is begun to take medicine, serve on three, every day three times, each 2 grams, boiled water drug delivery.
Claims (1)
1, a kind of Chinese medicine oral capsule Xianglianzi for contraception made that is used for contraception of woman, it is characterized in that it grinds smalls jointly by Herba Lysimachiae foenum-graeci 15-25 part, Cottonseed 10-20 part, Herba Spirodelae 5-15 part, Semen Persicae 5-15 part, RADIX CURCUMAE, 5-15 part, Herba Andrographis 5-15 part, Radix Arnebiae (Radix Lithospermi) 5-15 part, Fructus Psoraleae 5-15 part, Radix Angelicae Sinensis 5-15 part, Rhizoma Chuanxiong 5-12 part, Radix Cyathulae 5-12 part, Herba Saussureae Involueratae 1-10 part and incapsulates and make.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95118955A CN1057921C (en) | 1995-12-08 | 1995-12-08 | Oral capsule Xianglianzi for contraception made of traditional Chinese medicine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN95118955A CN1057921C (en) | 1995-12-08 | 1995-12-08 | Oral capsule Xianglianzi for contraception made of traditional Chinese medicine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1152450A CN1152450A (en) | 1997-06-25 |
| CN1057921C true CN1057921C (en) | 2000-11-01 |
Family
ID=5081832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN95118955A Expired - Fee Related CN1057921C (en) | 1995-12-08 | 1995-12-08 | Oral capsule Xianglianzi for contraception made of traditional Chinese medicine |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1057921C (en) |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084402A (en) * | 1992-09-21 | 1994-03-30 | 王暑轸 | Chinese traditional medicinal contraceptive pellet |
| CN1090498A (en) * | 1993-02-01 | 1994-08-10 | 杨芳林 | Lady's oral contraception Chinese patent medicine and preparation method |
-
1995
- 1995-12-08 CN CN95118955A patent/CN1057921C/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1084402A (en) * | 1992-09-21 | 1994-03-30 | 王暑轸 | Chinese traditional medicinal contraceptive pellet |
| CN1090498A (en) * | 1993-02-01 | 1994-08-10 | 杨芳林 | Lady's oral contraception Chinese patent medicine and preparation method |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1152450A (en) | 1997-06-25 |
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| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| C19 | Lapse of patent right due to non-payment of the annual fee | ||
| CF01 | Termination of patent right due to non-payment of annual fee |