CN1056087C - Method for preparation of biofunctional medical adhesive-bonded fabric dressing and its products - Google Patents

Abstract

The invention relates to a manufacturing method of a biofunctional medical non-woven dressing and products thereof. In the present invention, the chitosan-alginate mixed fiber pre-punched non-woven fabric is used as the bottom layer, and the pre-punched non-woven fabric of alginate or other water-absorbing fibers is used as the upper layer. production. The preparation method of the medical non-woven fabric of the invention is simple and convenient, the yield is high, and the processing cost is low. The product of the invention has broad-spectrum antibacterial, promotes healing, reduces scars, stops bleeding, and integrates multiple biological functions of chitosan and alginate.

Description

Production method and product of biofunctional medical non-woven dressing

The invention relates to the field of wound dressings, in particular to a method for preparing biofunctional medical non-woven dressings and products thereof.

WO89/12471 discloses the method for making calcium alginate fiber non-woven fabric, this method makes calcium alginate fiber by wet spinning process, then adjusts the calcium/na ratio in alginate by post-treatment process to obtain Calcium alginate/sodium salt fibers suitable for medical hemostatic dressings are obtained, wherein the content of sodium salts determines the ability to form a hemostatic gel layer, and calcium ions act as thrombin. The post-treatment process of this non-woven dressing is complicated, higher cost.

EP0171254 discloses deacetylation of chitin fibers, that is, after high-temperature alkali treatment, mixing with polyvinyl alcohol fibers to make paper, or deacetylation after weaving into cloth as a medical dressing with a healing effect. The -NH ₂ gene produced by acetylation has higher biological activity and gel-forming ability. In Japanese Patent Application No. 62-170254, chitosan fibers are partially restored to acetylation, that is, they are impregnated with anhydrous acetic acid containing methanol, etc., and then mixed with polyvinyl alcohol fibers to make paper or weave them into cloth to improve water resistance. The processing cost of these two methods is very high, and the hemostatic effect is not ideal.

CN1067279A discloses a method for preparing biofunctional medical non-woven fabric by mixing chitin fiber and alginate fiber for papermaking and its products. However, the ability of chitin fibers to form gels is poor, and the processing cost is much higher than that of chitosan fibers and alginate fibers. poor.

The object of the present invention is to provide a method for preparing biofunctional medical non-woven dressing and its products. This kind of non-woven fabric has good bulkiness, softness and air permeability, good shape-forming and shape-retaining properties, strong heat preservation and moisturizing performance, excellent bio-adaptability and the functions of stopping bleeding, promoting healing and reducing scars. The preparation method is simple and reasonable. ,low cost.

The purpose of the present invention is achieved like this: provide a kind of manufacture method of biological function medical non-woven dressing, described method comprises the steps:

a) mixing chitosan short fibers with alginate short fibers wherein the weight ratio of sodium ions and calcium ions is 10:90-30:70;

b) combing the mixed fiber obtained in step a) into a net through a carding machine, then laying the net, and pre-punching to obtain a pre-punched non-woven fabric of chitosan-alginate mixed fiber;

c) Carding alginate short fibers or other water-absorbing fibers in which the weight ratio of sodium ions to calcium ions is 10:90-30:70 is carded into a web, and then the web is laid and pre-acupunctured to obtain a single Prepunched nonwovens of alginate fibers or other absorbent fibers;

d) The chitosan-alginate mixed fiber pre-spun non-woven fabric made in step b) is the bottom layer, and the single alginate or other water-absorbent fiber pre-punched non-woven fabric made in c) step is the upper layer , on the main acupuncture machine through double-layer composite acupuncture, to obtain biofunctional medical non-woven dressings.

The mixing ratio of chitosan short fibers and alginate short fibers in the step a) is: chitosan short fibers account for 5%-100% of the total weight of chitosan short fibers and alginate short fibers. The other water-absorbent fibers in step c) are cotton fibers, vinylon fibers or viscose fibers. In the biofunctional medical nonwoven dressing described in a) step, the weight per unit area as the chitosan-alginate mixed fiber nonwoven fabric is 20-200 g/square meter; the single alginic acid as the upper layer The weight per unit area of salt or its water-absorbent fiber prepunched nonwoven fabric is 40-400 grams per square meter.

Another object of the present invention is achieved by providing a biofunctional medical non-woven dressing product. After the prionate short fibers are mixed, the pre-punched non-gauze cloth of the chitosan-alginate mixed fiber is carded, laid and pre-needled as the bottom layer, and the weight ratio of sodium ions and calcium ions is 10:90- 30:70 alginate staple fiber or other water-absorbing fiber carded, laid and pre-needled single alginate or other water-absorbing fiber pre-punched non-woven fabric as the upper double-layer composite needle Thorn non-woven dressing. The mixing ratio of chitosan short fibers and alginate short fibers in the prefabricated non-woven fabric of chitosan-alginate mixed fibers is: chitosan short fibers account for the total weight of chitosan short fibers and alginate short fibers 5-100%. Other water-absorbent fibers as upper layer The other water-absorbent fibers in the prepunched nonwoven are cotton fibers, vinylon fibers or viscose fibers. The weight per unit area of the chitosan-alginate mixed fiber prepunched nonwoven fabric as the bottom layer is 20-200 g/m2; The weight per unit area is 40-400 grams per square meter.

The present invention will be described in detail below in conjunction with the examples.

Chitosan is a biopolymer composed of glucosamine, which is obtained by deacetylation of acetylglucosamine present in shrimp skin, crab shell, silkworm chrysalis skin and other substances. Modern medical research shows that it has the functions of broad-spectrum antibacterial, inhibiting fibroblast growth, and promoting the growth of epidermal cells, so it can prevent infection and reduce scars. The weight ratio of sodium ions to calcium ions is 10:90-30 :70 alginate is an active ingredient extracted from brown kelp, a biopolymer salt composed of mannuronic acid and gulonic acid, rich in active calcium as the main blood coagulation factor, and thus has excellent For hemostasis, the above two biopolymers have high liquid absorption, biocompatibility and biodegradable absorbability. In the present invention, selected chitosan fiber and alginic acid fiber are mixed and processed into non-woven fabric, mainly considering the following points:

1) It is less costly than chitin fiber (higher than alginate fiber);

2) It has a stronger ability to form a gel than chitin fibers, and plays a dual role in physical hemostasis and biochemical hemostasis together with the active calcium coagulation factor in alginate, so that the calcium alginate fiber obtained by wet spinning can There is no need for post-processing to adjust the calcium/sodium ratio to control the gel forming ability;

3) It has a broad-spectrum antibacterial effect, promotes healing and reduces scars.

Example 1

Crab shells were washed and dried and crushed through a sieve with 50 holes per 6.5 square centimeters, decalcified in 7.4% salt solution at 10°C for 30 minutes, washed with water and deproteinized in 4% NaOH solution at 85°C for 3 hours, Chitin was obtained by washing with water until it became neutral. After treating chitin in 50% NaOH solution at 100°C for 4 hours, it was neutralized with hydrochloric acid, washed repeatedly, and dried to obtain chitosan. Dissolve chitosan in 5% (volume percent) acetic acid solution at 25°C to obtain 7% spinning stock solution, which is filtered and defoamed with a spinneret with a pore size of 0.08 mm and a hole number of 2000 holes Extruded into a 10% NaOH aqueous solution, the tow was drawn out at a speed of 6 m/min, drawn 1.4 times, and fully washed and dried to obtain a chitosan fiber with a monofilament fineness of 1.5d and a strength of 2.5g/d. Dissolve sodium alginate in water to make 7% spinning stock solution, and extrude it into a coagulation bath containing 0.7% calcium chloride through a spinneret with a hole diameter of 0.10 mm and a hole number of 10,000 holes after filtration and defoaming After solidification and forming, the tow is drawn out at a speed of 10 m/min and drawn 2.0 times to obtain an alginate with a single filament fineness of 1.5d, a strength of 2.9g/d, and a weight ratio of sodium ions to calcium ions of 50:50. fiber. After the two kinds of fibers are cut into short fibers of 60 mm length, they are mixed and carded into a net at a ratio of 50/50 on a carding machine, and the mixed fibers with a ^unit area weight of 30 g/m are obtained through laying and pre-needling. spinning. Using a single alginate as a raw material, through the same processing procedure, a prepunched non-woven fabric of alginate fiber with a unit area weight of 70 g/ ^m2 was obtained. The non-woven fabric with mixed material is used as the bottom layer, and the non-woven fabric with single material is used as the upper layer, and the biofunctional medical non-woven fabric dressing is produced after double-layer composite needle punching on the main needle punching machine. The preparation method and the goods of this medical non-woven dressing fully reach the object of the present invention.

Example 2

The mixed fiber prepunched non-woven fabric described in Example 1 is the bottom layer, and the cotton fiber non-woven fabric with a weight per unit area of 150 g/ ^m is the upper layer, and the obtained product is obtained after double-layer composite needle punching on the main needle punching machine. Describe biofunctional non-woven medical dressings. This non-woven fabric is suitable for clinical use on the body surface, and the cost is relatively low.

Example 3

With the chitosan staple fiber described in embodiment 1 carded into a net on a carding machine, the weight per unit area obtained with a single chitosan fiber as a raw material is 50 g/ ^m Pre-needled non-woven fabric through laying and pre-needling; Using a single alginate as a raw material, through the same processing procedure, a pre-punched non-woven fabric of alginate fiber with a weight per unit area of 70 g/ ^m2 is obtained. The pre-punched non-woven fabric of a single chitosan fiber is used as the bottom layer. The biofunctional nonwoven medical dressing is prepared by using a single alginate fiber prepunched non-woven fabric as an upper layer, and after double-layer composite needle punching on a main needle punching machine. The prepared product also achieves the object of the present invention.

The present invention has good effects. Compared with the non-woven fabric obtained by wet papermaking, the dry-laid needle-punched non-woven fabric made of the carapace-alginate mixed fiber used in the present invention has bulkiness, softness, good air permeability, shape-shaping and shape-retaining properties Strong advantages; compared with the weaving process, the process is simple, the yield is high, and the cost is reduced. The biofunctional medical non-woven dressing product of the present invention simultaneously integrates multiple functions of chitosan and alginate and strengthens the hemostatic function. It has broad-spectrum antibacterial properties, promotes healing, reduces scars, has high liquid absorption, biocompatibility and biodegradable absorbability, and has excellent shape-forming and shape-retaining properties.

Claims (8)

1, the manufacture method of medical non-woven cloth with organism function dressing is characterized in that having the following steps:

A) with the chitosan short fiber and wherein sodium ion and calcium ion weight ratio be 10: 90-30: 70 alginate short fiber mixes;

B) with a) step gained composite fibre through the carding machine carding, again through lapping, pre-pin is perverse, obtains chitosan-pre-needled non-woven cloth of alginate composite fibre;

C) wherein sodium ion and calcium ion weight ratio are 10: 90-30: 70 alginate short fiber or other hygroscopicity fibre are through the carding machine carding, again through lapping, pre-pin is perverse, obtains the pre-needled non-woven cloth of single alginate fiber or other hygroscopicity fibre;

D) with b) the made chitosan of step-pre-needled non-woven cloth of alginate composite fibre is bottom, with c) the pre-needled non-woven cloth of the made single alginate of step or other hygroscopicity fibre is the upper strata, perverse through the two-layer compound pin on the perverse machine of main pin, obtain medical non-woven cloth with organism function dressing.

2, according to the manufacture method of the described living body function medical adhesive-bonded fabric dressing of claim 1, it is characterized in that: the chitosan short fiber in a) step and the mixed proportion of alginate short fiber are: the chitosan short fiber accounts for the 5%-100% of chitosan short fiber and alginate short fiber gross weight.

3, according to the manufacture method of the described medical non-woven cloth with organism function dressing of claim 1, it is characterized in that: at c) other hygroscopicity fibre described in the step is cotton fiber, vinylon fiber or viscose rayon.

4, according to the manufacture method of each described medical non-woven cloth with organism function dressing of claim 1-3, it is characterized in that: in a) dressing of medical non-woven cloth with organism function described in the step, as the weight per unit area of chitosan-alginate composite fibre non-woven fabrics be the 20-200 gram/square metre; As the weight per unit area of the single alginate on upper strata or its pre-needled non-woven cloth of hygroscopicity fibre be the 40-400 gram/square metre.

5, the medical non-woven cloth with organism function dressing procucts is characterized in that: described goods be with the chitosan short fiber and wherein sodium ion and calcium ion weight ratio be 10: 90-30: 70 alginate short fiber mixes after carding, the pre-needled non-woven cloth of chitosan-alginate composite fibre that lapping and pre-pin are perverse is as bottom, with wherein sodium ion and calcium ion weight ratio is 10: 90-30: 70 alginate short fiber or other hygroscopicity fibre are through carding, the single alginate that lapping and pre-pin are perverse or the pre-needled non-woven cloth of other hygroscopicity fibre are as the two-layer compound pin needled non-woven cloth dressing on upper strata.

6, according to the described medical non-woven cloth with organism function dressing procucts of claim 5, it is characterized in that: in the prefabricated non-woven fabrics of chitosan-alginate composite fibre, the mixed proportion of chitosan short fiber and alginate short fiber is: the chitosan short fiber accounts for the 5-100% of chitosan short fiber and alginate short fiber gross weight.

7, according to the described medical non-woven cloth with organism function dressing procucts of claim 5, it is characterized in that: as other hygroscopicity fibre in the pre-needled non-woven cloth of other hygroscopicity fibre on upper strata is cotton fiber, vinylon fiber or viscose rayon.

8, according to each described living body function medical adhesive-bonded fabric dressing goods of claim 5-7, it is characterized in that: as the weight per unit area of the chitosan-pre-needled non-woven cloth of alginate composite fibre of bottom be the 20-200 gram/square metre; As the weight per unit area of the single alginate on upper strata or the pre-needled non-woven cloth of other hygroscopicity fibre be the 40-400 gram/square metre.