CN105582527B - A kind of composition and preparation method thereof improving moisture of skin - Google Patents
A kind of composition and preparation method thereof improving moisture of skin Download PDFInfo
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- CN105582527B CN105582527B CN201511007992.1A CN201511007992A CN105582527B CN 105582527 B CN105582527 B CN 105582527B CN 201511007992 A CN201511007992 A CN 201511007992A CN 105582527 B CN105582527 B CN 105582527B
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- roselle
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- 238000002360 preparation method Methods 0.000 title claims abstract description 27
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims abstract description 62
- 108010035532 Collagen Proteins 0.000 claims abstract description 41
- 102000008186 Collagen Human genes 0.000 claims abstract description 41
- 240000004153 Hibiscus sabdariffa Species 0.000 claims abstract description 41
- 235000001018 Hibiscus sabdariffa Nutrition 0.000 claims abstract description 41
- 229920001436 collagen Polymers 0.000 claims abstract description 41
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 39
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- 238000004108 freeze drying Methods 0.000 claims 1
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- 210000003491 skin Anatomy 0.000 abstract description 67
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- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 abstract description 6
- 102000004169 proteins and genes Human genes 0.000 abstract description 6
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- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 abstract description 3
- 229920002683 Glycosaminoglycan Polymers 0.000 abstract description 3
- 108010050808 Procollagen Proteins 0.000 abstract description 3
- 229930003268 Vitamin C Natural products 0.000 abstract description 3
- 229930014669 anthocyanidin Natural products 0.000 abstract description 3
- 150000001452 anthocyanidin derivatives Chemical class 0.000 abstract description 3
- 235000008758 anthocyanidins Nutrition 0.000 abstract description 3
- 230000003064 anti-oxidating effect Effects 0.000 abstract description 3
- 150000001875 compounds Chemical class 0.000 abstract description 3
- 150000007524 organic acids Chemical class 0.000 abstract description 3
- 229920001277 pectin Polymers 0.000 abstract description 3
- 239000001814 pectin Substances 0.000 abstract description 3
- 235000010987 pectin Nutrition 0.000 abstract description 3
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- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
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- 244000061458 Solanum melongena Species 0.000 description 2
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- 235000010378 sodium ascorbate Nutrition 0.000 description 2
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 2
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- PMMYEEVYMWASQN-DMTCNVIQSA-N Hydroxyproline Chemical compound O[C@H]1CN[C@H](C(O)=O)C1 PMMYEEVYMWASQN-DMTCNVIQSA-N 0.000 description 1
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 description 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
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- 241000220317 Rosa Species 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
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- 235000005911 diet Nutrition 0.000 description 1
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- 239000003085 diluting agent Substances 0.000 description 1
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- 239000012153 distilled water Substances 0.000 description 1
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- PMMYEEVYMWASQN-UHFFFAOYSA-N dl-hydroxyproline Natural products OC1C[NH2+]C(C([O-])=O)C1 PMMYEEVYMWASQN-UHFFFAOYSA-N 0.000 description 1
- 235000006694 eating habits Nutrition 0.000 description 1
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- 210000003754 fetus Anatomy 0.000 description 1
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- 238000004519 manufacturing process Methods 0.000 description 1
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- 210000003097 mucus Anatomy 0.000 description 1
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- 239000011148 porous material Substances 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 239000011591 potassium Substances 0.000 description 1
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- 239000002344 surface layer Substances 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005550 wet granulation Methods 0.000 description 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/06—Fungi, e.g. yeasts
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- Health & Medical Sciences (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Engineering & Computer Science (AREA)
- Mycology (AREA)
- Alternative & Traditional Medicine (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Molecular Biology (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a kind of compositions and preparation method thereof for improving moisture of skin, with gumbo, bolete, roselle, collagen, hyaluronic acid, sodium isoascorbate, vitamin E prescription, gumbo contains pectin abundant and glutinous polysaccharide component, bolete can promote keratinocyte proliferation and I procollagen type protein expression, roselle contains anthocyanidin abundant and organic acid, collagen is a kind of extracellular protein, has the effects that moisturizing and nourishes rough skin, wrinkle resistant reparation；Hyaluronic acid is to be distributed widely in the intracorporal acidic mucopolysaccharide of people, has special water retention, then is aided with vitamin C, vitamin E with antioxidation and constitutes compound product, coordinates synergy, being experimentally verified that has the function of good improvement moisture of skin.
Description
Technical field
The present invention relates to a kind of compositions and preparation method thereof for improving moisture of skin.
Background technique
Water is human body sheet, and the content of water is different according to its different developing stage in human body.The intracorporal water of fetus
Point account for about 90%, cradle 90%, person between twenty and fifty 70%, person in middle and old age 60% or even 50%, so the astogeny process of people
It is a kind of process of loss of moist.Water is to protect skin cleaning, moisten, delicate special efficacy and cheap enamel.Human skin
Surface layer moisture content at 12~15%, skin smooth and it is flexible.Once lacking moisture, caused drying can seriously affect skin
Health.Studies have shown that eyes are in drying regime 3 hours, and it can be intense darkness without light in one day, without expression；Hand is in drying
State 1 day, need restore original elasticity within 3 days；Face is in drying regime 3 days, and skin can peeling, long wrinkle, skin pigment
Deposition is accelerated, and drying time is more than 7 days, can generate color spot, accumulates toxin, needs restore within 3 months；Whole body drying regime is more than 30
It, generates various intractable color spots, wrinkle, and skin aging speed is accelerated 3 years.
For improving moisture of skin, more concerns were placed on cosmetics in the past, and present people pursue from inside to outside
Beauty, start focus on body interior adjust, " dietotherapy " is pursued by more and more people, need it is a kind of can from inherence raise,
Improve the dietary product of moisture of skin.
Summary of the invention
It is an object of the invention in place of overcome the deficiencies in the prior art, provide a kind of composition for improving moisture of skin
And preparation method thereof, with gumbo, bolete, roselle, collagen, hyaluronic acid, sodium isoascorbate, vitamin E prescription, gumbo
Containing pectin abundant and glutinous polysaccharide component, bolete can promote keratinocyte proliferation and I procollagen type protein expression, rose
Eggplant contains anthocyanidin abundant and organic acid, and collagen is a kind of extracellular protein, has moisturizing and nourishes rough skin, wrinkle resistant repairs
The effects of multiple；Hyaluronic acid is to be distributed widely in the intracorporal acidic mucopolysaccharide of people, has special water retention, then be aided with and have
Vitamin C, the vitamin E of antioxidation constitute compound product, coordinate synergy, are experimentally verified that with good improvement skin
The effect of moisture.
The technical solution adopted by the present invention to solve the technical problems first is that:
A kind of composition improving moisture of skin, the raw material of the composition is according to the mass fraction, comprising: and gumbo 100~
It is 140 parts, 100~140 parts of bolete, 100~140 parts of roselle, 40~80 parts of collagen, 0.5~4 part of hyaluronic acid, different
0.3~2 part of sodium ascorbate, 1~5 part of vitamin E.
In one embodiment: the raw material of the composition is according to the mass fraction, comprising:
120 parts of gumbo, 120 parts of bolete, 120 parts of roselle, 60 parts of collagen, 2 parts of hyaluronic acid, sodium isoascorbate 1
Part, 4 parts of vitamin E；Or
140 parts of gumbo, 100 parts of bolete, 110 parts of roselle, 70 parts of collagen, 4 parts of hyaluronic acid, sodium isoascorbate 0.5
Part, 2 parts of vitamin E；Or
100 parts of gumbo, 110 parts of bolete, 140 parts of roselle, 50 parts of collagen, 0.5 part of hyaluronic acid, sodium isoascorbate 2
Part, 5 parts of vitamin E；Or
110 parts of gumbo, 140 parts of bolete, 100 parts of roselle, 80 parts of collagen, 1 part of hyaluronic acid, sodium isoascorbate 0.3
Part, 1 part of vitamin E；Or
130 parts of gumbo, 130 parts of bolete, 130 parts of roselle, 40 parts of collagen part, 3 parts of hyaluronic acid, sodium isoascorbate
1.5 parts, 3 parts of vitamin E.
The technical solution adopted by the present invention to solve the technical problems second is that:
The preparation method of the composition of above-mentioned improvement moisture of skin, comprising:
1) it takes selected parts by weight gumbo and bolete, is added that 4~8 times of water are slightly boiled to extract 1~3 time, 0.5~2 hour every time,
Filtering, combined extract are concentrated into relative density 1.10~1.30 at 60 DEG C, obtain concentrate I, or concentrate I is further sprayed
Mist is dry, obtains extract powder I；
2) take selected parts by weight roselle that 6~10 times of amount water are added, 80~90 DEG C are extracted 0.5~3 hour, are collected and are extracted
Liquid is concentrated into relative density 1.10~1.30 at 60 DEG C, obtains concentrate II, or concentrate II is further freeze-dried, is made
Extract powder II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I and concentrate are taken
II, or be uniformly mixed with extract powder I and extract powder II to get the composition of the improvement moisture of skin.
In one embodiment: including:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of water 2 times is added, for the first time plus the slightly boiled extraction 2 of 6 times of water is small
When, for the second time plus 4 times of water extract 0.5 hour, and filtering, combined extract is concentrated into relative density 1.20 at 60 DEG C, is extracted
Object I；Extract I is spray-dried, extract powder is made；
2) take selected parts by weight roselle that 8 times of amount water are added, 85 DEG C are extracted 2 hours, and extracting solution, as extract are collected
Ⅱ；Extract II is freeze-dried, roselle freeze-dried powder is made；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned extract powder, roselle is taken to freeze
Dry powder blend is uniformly to get the composition of the improvement moisture of skin.
In one embodiment: further include: 4) composition of step 3) resulting improvement moisture of skin is taken, customary adjuvant is added,
It is uniformly mixed, according to common process, clinically acceptable preparation is made.
The technical solution adopted by the present invention to solve the technical problems third is that:
A kind of composition or above-mentioned preparation side with the product for improving moisture of skin effect, for above-mentioned improvement moisture of skin
Customary adjuvant is added in the composition of method resulting improvement moisture of skin, such as diluent, disintegrating agent, lubricant, binder, coloring
Agent, corrigent etc., according to common process, clinically acceptable tablet obtained, capsule, granule, powder, mixture, ball
Agent, solution, syrup, ointment, gelling agent, film, medicinal tea, cataplasm, beverage, biscuit, candy, cake food, conveniently
Food.
The technical solution adopted by the present invention to solve the technical problems fourth is that:
Drug and/or health food and/or food of the composition of above-mentioned improvement moisture of skin in preparation improvement moisture of skin
Purposes on product.
The technical program compared with the background art, it has the following advantages:
Composition of the invention is by gumbo, bolete, roselle, collagen, hyaluronic acid, sodium isoascorbate, vitamin E
Composition.Gumbo (scientific name: Abelmoschus esculentus) is also known as okra, Abelmoschus esculentus in formula, popular name swordweed, purling
Eggplant.Okra emplastic rich in (sugared condensate), main component are pectin, viscous glycoprotein, vitamin A and potassium.
Viscous glycoprotein is a kind of by collagen and the polysaccharide of mucopolysaccharide material composition, protein mixture.Okra can improve skin
Skin moisture improves skin resistance.Bolete contains the nutriments abundant such as amino acid, vitamin, protein, active polysaccharide,
The ability that free radical drops clearly in human body can be enhanced, promote the proliferation of horn cell, the table of I procollagen type albumen can also be promoted
It reaches.Roselle, which contains to enrich, anthocyanidin and organic acid, has preferably oxidation resistance.Collagen be people's in-vivo content most
Protein abundant accounts for the one third of gross protein total amount in human body it includes glycine, proline and hydroxyproline is contained.Extensively
The general whole body that is distributed in respectively is organized, and is that reinforcing bar, the cement of human body mansion are protected in skin, bone, muscle, blood vessel, cartilaginous tissue
Various tissues are protected and linked, support the structure of human body, play important physiological function in vivo.Collagen accounts in skin
72%, 80% is collagen in corium, and collagen constitutes a fine and closely woven elasticated net in skin, locks moisture, branch
Support skin.The loss of collagen leads to the elasticated net fracture for supporting skin, and skin histology atrophy collapses, and skin will be shown
The aging phenomenons such as coarse, the dim, color spot of now dry, coarse, loose, wrinkle, pore.Replenishing collagen, for that can improve
Skin problem delays senescence.Hyaluronic acid (HA) is that a kind of acid mucus that widely distributed each group in vivo is knitted sticks polysaccharide
Component is to resist the related immune system of disease and electrolyte balance regulation and control substance with human body, and constitute the master of dermis of skin
Want ingredient.Hyaluronic acid has special water retention, is the substance that moisture retention is best in presently found nature, referred to as
Ideal natural moisturizing factor.Although hyaluronic acid can be synthesized in human body, accordingly reduced as the age increases synthetic quantity.One
Hyaluronic acid amount is reduced in denier skin, just becomes the major reason that skin ageing and skin elasticity pliability reduce.For this purpose, makeup
Mostly for the purpose of keeping skin to lubricate, functional effect is moisturizing and increases skin elasticity many commodity of product industry production
And it is soft and moist, these effects also provide important foundation to develop beauty food.Vitamin C, vitamin E have antioxidation.
Gumbo, bolete, roselle, collagen, hyaluronic acid, sodium isoascorbate, vitamin E form compound product, and improving improves skin
Moisture effect.
Specific embodiment
The contents of the present invention are illustrated below by embodiment:
Embodiment 1
A kind of composition improving moisture of skin, the raw material of the composition is according to the mass fraction, comprising: and 120 parts of gumbo,
120 parts of bolete, 120 parts of roselle, 60 parts of collagen, 2 parts of hyaluronic acid, 1 part of sodium isoascorbate, 4 parts of vitamin E.
The preparation method of the composition of above-mentioned improvement moisture of skin includes:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of water 2 times is added, for the first time plus the slightly boiled extraction 2 of 6 times of water is small
When, for the second time plus 4 times of water extract 0.5 hour, and filtering, combined extract is concentrated into relative density 1.20 at 60 DEG C, is extracted
Object I；Extract I is spray-dried, extract powder is made；
2) take selected parts by weight roselle that 8 times of amount water are added, 85 DEG C are extracted 2 hours, and extracting solution, as extract are collected
Ⅱ；Extract II is freeze-dried, roselle freeze-dried powder is made；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned extract powder, roselle is taken to freeze
Dry powder blend is uniform, and powder is made in packing.
Embodiment 2
The present embodiment and embodiment 1 the difference is that: the raw material of the composition is according to the mass fraction, comprising: the autumn
140 parts of certain herbaceous plants with big flowers, 100 parts of bolete, 110 parts of roselle, 70 parts of collagen, 4 parts of hyaluronic acid, 0.5 part of sodium isoascorbate, vitamin E
2 parts；
The preparation method of the composition of above-mentioned improvement moisture of skin includes:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of water 2 times is added, for the first time plus the slightly boiled extraction 1 of 8 times of water is small
When, for the second time plus 6 times of water extract 0.5 hour, and filtering, combined extract is concentrated into relative density 1.30 at 60 DEG C, is concentrated
Liquid I；
2) take selected parts by weight roselle that 10 times of amount water are added, 90 DEG C are extracted 0.5 hour, are collected extracting solution, are concentrated into 60
Relative density 1.30 at DEG C obtain concentrate II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I, concentrate II are taken
And appropriate amount of auxiliary materials is uniformly mixed, high speed wet granulation, dry, tablet is made in tabletting.
Embodiment 3
The present embodiment and embodiment 1 the difference is that: the raw material of the composition is according to the mass fraction, comprising: the autumn
100 parts of certain herbaceous plants with big flowers, 110 parts of bolete, 140 parts of roselle, 50 parts of collagen, 0.5 part of hyaluronic acid, 2 parts of sodium isoascorbate, vitamin E
5 parts；
The preparation method of the composition of above-mentioned improvement moisture of skin includes:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of water 3 times is added, for the first time plus 8 times of water extract 1 hour,
For the second time plus 6 times of water extract 0.5 hour, and third time adds 4 times of water extractions 0.5 hour, and filtering, combined extract is concentrated into 60 DEG C
Lower relative density 1.15, obtains concentrate I；
2) take selected parts by weight roselle that 6 times of amount water are added, 85 DEG C are extracted 3 hours, are collected extracting solution, are concentrated at 60 DEG C
Relative density 1.15 obtains concentrate II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I, concentrate II are taken
And appropriate amount of auxiliary materials is uniformly mixed, and is 600 parts by weight with water adjustment total amount, filling, mixture is made in sterilizing.
Embodiment 4
The present embodiment and embodiment 1 the difference is that: the raw material of the composition is according to the mass fraction, comprising: the autumn
110 parts of certain herbaceous plants with big flowers, 140 parts of bolete, 100 parts of roselle, 80 parts of collagen, 1 part of hyaluronic acid, 0.3 part of sodium isoascorbate, vitamin E
1 part；
The preparation method of the composition of above-mentioned improvement moisture of skin includes:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of water 2 times is added, for the first time plus 8 times of water extractions 1.5 are small
When, for the second time plus 6 times of water extract 1 hour, and filtering, combined extract is concentrated into relative density 1.25 at 60 DEG C, obtains concentrate
Ⅰ；
2) take selected parts by weight roselle that 8 times of amount water are added, 90 DEG C are extracted 1 hour, are collected extracting solution, are concentrated at 60 DEG C
Relative density 1.25 obtains concentrate II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I, concentrate II are taken
And appropriate amount of auxiliary materials is uniformly mixed, and squeezes granulation, dry, granule is made in packing.
Embodiment 5
The present embodiment and embodiment 1 the difference is that: the raw material of the composition is according to the mass fraction, comprising: the autumn
130 parts of certain herbaceous plants with big flowers, 130 parts of bolete, 130 parts of roselle, 40 parts of collagen part, 3 parts of hyaluronic acid, 1.5 parts of sodium isoascorbate, dimension life
3 parts of plain E.
The preparation method of the composition of above-mentioned improvement moisture of skin includes:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of 8 times of water 2 hours is added, filters, combined extract is dense
It is reduced to relative density 1.10 at 60 DEG C, obtains concentrate I；
2) take selected parts by weight roselle that 10 times of amount water are added, 80 DEG C are extracted 2 hours, are collected extracting solution, are concentrated into 60 DEG C
Lower relative density 1.10, obtains concentrate II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I, concentrate II are taken
And appropriate amount of auxiliary materials is uniformly mixed, and is 3600 parts by weight with water adjustment total amount, filling, beverage is made in sterilizing.
Skilled person will appreciate that when technical parameter of the invention changes in the following range, it is contemplated that obtain
Same as the previously described embodiments or similar technical effect:
A kind of composition improving moisture of skin, the raw material of the composition is according to the mass fraction, comprising: and gumbo 100~
It is 140 parts, 100~140 parts of bolete, 100~140 parts of roselle, 40~80 parts of collagen, 0.5~4 part of hyaluronic acid, different
0.3~2 part of sodium ascorbate, 1~5 part of vitamin E.
The preparation method of the composition of above-mentioned improvement moisture of skin, comprising:
1) it takes selected parts by weight gumbo and bolete, is added that 4~8 times of water are slightly boiled to extract 1~3 time, 0.5~2 hour every time,
Filtering, combined extract are concentrated into relative density 1.10~1.30 at 60 DEG C, obtain concentrate I, or concentrate I is further sprayed
Mist is dry, obtains extract powder I；
2) take selected parts by weight roselle that 6~10 times of amount water are added, 80~90 DEG C are extracted 0.5~3 hour, are collected and are extracted
Liquid is concentrated into relative density 1.10~1.30 at 60 DEG C, obtains concentrate II, or concentrate II is further freeze-dried, is made
Extract powder II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I and concentrate are taken
II, or be uniformly mixed with extract powder I and extract powder II to get the composition of the improvement moisture of skin.
Further include: 4) composition of step 3) resulting improvement moisture of skin is taken, customary adjuvant is added, is uniformly mixed, presses
Clinically acceptable preparation is made in more solito technique.
A kind of composition or above-mentioned preparation side with the product for improving moisture of skin effect, for above-mentioned improvement moisture of skin
Customary adjuvant, according to common process, clinically acceptable obtained is added in the composition of method resulting improvement moisture of skin
Agent, capsule, granule, powder, mixture, pill, solution, syrup, ointment, gelling agent, film, medicinal tea, cataplasm,
Beverage, biscuit, candy, cake food, instant food.
The effect of following experimental examples can be achieved in above-described embodiment:
Experimental example
Tested material is the pulvis prepared by inventive formulation, technique.It is selected 30~50 years old by the principle of voluntariness, skin moisture value
≤ 12 subject 100.It is shone using itself front and back reply and compares two kinds of forms between group.100 subjects are randomly divided into reality
Group and two control groups are tested, experimental group takes the composition of the improvement moisture of skin of the embodiment of the present invention 1, and control group 1 takes phase
With character without effect placebo, this composition that control group 2 takes identical character goes the control after gumbo, bolete, roselle
Product.Each group is each taking 1 bag, and dose is 5g/ days, and continuous 30 days, subject must not take other holding skins during test-meal
The article of skin moisture content and the cosmetics for using influence result judgement.Original eating habit, normal diet are not changed during test.
1 efficiency observation
Measuring method: the moisture content of test forehead glabella skin.
Determination of the environment: spacious, ventilation condition is good, the stable inspection chamber of the space environments such as temperature, humidity is carried out.Pacifying
Distilled water is dipped in cleaning ball under quiet state and cleans tested position, dries the measurement for carrying out moisture content in latter 15 minutes, measurement before and after test-meal
Work is by same instrument, same to one man operation.
2 data processings and result judgement
Skin moisture variation before and after test-meal is counted.
Effect criterion:
Effective: moisture content is improved, and has significant difference through statistical test.
Invalid: moisture content does not significantly improve.
Test data is measurement data, can be examined and be analyzed with t.All own control data can use paired t-test,
Two groups of means compare using independent samples t-test, and the latter need to carry out homogeneity test of variance, to the data of Non-Gaussian Distribution or heterogeneity of variance
Carry out variable conversion appropriate, wait meet normal state variance it is neat after, carry out t inspection with the data of conversion；If change data still cannot
Meet normal state variance to require together, uses t ' inspection or rank sum test instead；But the logging data application order of the coefficient of variation too big (such as CV > 50%)
And inspection.
As a result judge: experimental group skin moisture is obviously improved, itself compares before and after test-meal and compared with the control group, difference is equal
There is conspicuousness, can determine that the given the test agent has the function of improving moisture of skin function.
2 experimental results
1 moisture of skin testing result (X ± s) of table
Note: comparing p < 0.05 in * group,#Compare p < 0.05 in group
Seen from table 1, experimental group moisture of skin is significantly improved, have compared with control group 1 significant difference (P <
0.05), there is significant difference (P < 0.05) before and after test-meal.Then 2 moisture of skin of control group does not significantly improve.
3 conclusions
50 subjects take improvement moisture of skin powder 30 days, comparing difference before experimental group moisture of skin and test-meal as required
There is conspicuousness (P < 0.01), skin moisture content significantly improves, and skin moisture content difference also has conspicuousness compared with the control group
(P<0.01).Illustrate that the composition of improvement moisture of skin of the invention has the function of improving moisture of skin, can be applied to prepare
Improve the drug and/or health food of moisture of skin.
The above is only the preferred embodiment of the present invention, the range implemented of the present invention that therefore, it cannot be limited according to, i.e., according to
Equivalent changes and modifications made by the invention patent range and description, should still be within the scope of the present invention.
Claims (11)
1. it is a kind of improve moisture of skin composition, it is characterised in that: the raw material of the composition according to the mass fraction, under
Column group is grouped as: 100~140 parts of gumbo, 100~140 parts of bolete, and 100~140 parts of roselle, 40~80 parts of collagen,
0.5~4 part of hyaluronic acid, 0.3~2 part of sodium isoascorbate, 1~5 part of vitamin E.
2. a kind of composition for improving moisture of skin according to claim 1, it is characterised in that: the raw material of the composition
According to the mass fraction, it is made of following component:
120 parts of gumbo, 120 parts of bolete, 120 parts of roselle, 60 parts of collagen, 2 parts of hyaluronic acid, 1 part of sodium isoascorbate, dimension
Raw E4 parts of element；Or
140 parts of gumbo, 100 parts of bolete, 110 parts of roselle, 70 parts of collagen, 4 parts of hyaluronic acid, 0.5 part of sodium isoascorbate,
Vitamin E2 part；Or
100 parts of gumbo, 110 parts of bolete, 140 parts of roselle, 50 parts of collagen, 0.5 part of hyaluronic acid, 2 parts of sodium isoascorbate,
5 parts of vitamin E；Or
110 parts of gumbo, 140 parts of bolete, 100 parts of roselle, 80 parts of collagen, 1 part of hyaluronic acid, 0.3 part of sodium isoascorbate,
Vitamin e1 part；Or
130 parts of gumbo, 130 parts of bolete, 130 parts of roselle, 40 parts of collagen part, 3 parts of hyaluronic acid, sodium isoascorbate 1.5
Part, 3 parts of vitamin E.
3. a kind of preparation method of composition for improving moisture of skin according to claim 1 or 2, it is characterised in that: packet
It includes:
1) it takes selected parts by weight gumbo and bolete, is added that 4~8 times of water are slightly boiled to extract 1~3 time, 0.5~2 hour every time, mistake
Filter, combined extract are concentrated into relative density 1.10~1.30 at 60 DEG C, obtain concentrate I, or concentrate I is further spraying
It is dry, obtain extract powder I；
2) take selected parts by weight roselle that 6~10 times of amount water are added, 80~90 DEG C are extracted 0.5~3 hour, and extracting solution is collected, dense
It is reduced to relative density 1.10~1.30 at 60 DEG C, obtains concentrate II, or concentrate II is further freeze-dried, extract powder is made
II；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned concentrate I and concentrate II are taken, or
It is uniformly mixed with extract powder I and extract powder II to get the composition of the improvement moisture of skin.
4. a kind of preparation method of composition for improving moisture of skin according to claim 1 or 2, it is characterised in that: packet
It includes:
1) selected parts by weight gumbo and bolete are taken, the slightly boiled extraction of water 2 times is added, adds 6 times of water are slightly boiled to extract for the first time 2 hours,
For the second time plus 4 times of water extract 0.5 hour, and filtering, combined extract is concentrated into relative density 1.20 at 60 DEG C, obtains extract
I；Extract I is spray-dried, extract powder is made；
2) take selected parts by weight roselle that 8 times of amount water are added, 85 DEG C are extracted 2 hours, and extracting solution, as extract II are collected；It will
Extract II freeze-drying, is made roselle freeze-dried powder；
3) selected parts by weight collagen, hyaluronic acid, sodium isoascorbate, vitamin E and above-mentioned extract powder, roselle freeze-dried powder are taken
It is uniformly mixed the composition to get the improvement moisture of skin.
5. a kind of preparation method of composition for improving moisture of skin according to claim 3, it is characterised in that: also wrap
It includes: 4) taking the composition of step 3) resulting improvement moisture of skin, customary adjuvant is added, be uniformly mixed, according to common process, system
Obtain clinically acceptable preparation.
6. a kind of preparation method of composition for improving moisture of skin according to claim 4, it is characterised in that: also wrap
It includes: 4) taking the composition of step 3) resulting improvement moisture of skin, customary adjuvant is added, be uniformly mixed, according to common process, system
Obtain clinically acceptable preparation.
7. a kind of with the product for improving moisture of skin effect, it is characterised in that: be improvement skin of any of claims 1 or 2
Customary adjuvant is added in the composition of moisture, according to common process, clinically acceptable tablet obtained, capsule, granule,
Powder, mixture, pill, solution, syrup, ointment, gelling agent, film, medicinal tea, cataplasm, beverage, biscuit, candy, cake
Select food, instant food.
8. a kind of with the product for improving moisture of skin effect, it is characterised in that: obtained for preparation method as claimed in claim 3
The composition of improvement moisture of skin customary adjuvant is added, according to common process, clinically acceptable tablet obtained, capsule
Agent, granule, powder, mixture, pill, solution, syrup, ointment, gelling agent, film, medicinal tea, cataplasm, beverage, cake
Dry, candy, cake food, instant food.
9. a kind of with the product for improving moisture of skin effect, it is characterised in that: obtained for preparation method as claimed in claim 4
The composition of improvement moisture of skin customary adjuvant is added, according to common process, clinically acceptable tablet obtained, capsule
Agent, granule, powder, mixture, pill, solution, syrup, ointment, gelling agent, film, medicinal tea, cataplasm, beverage, cake
Dry, candy, cake food, instant food.
10. a kind of with the product for improving moisture of skin effect, it is characterised in that: be preparation method described in claim 5 or 6
Customary adjuvant is added in the composition of resulting improvement moisture of skin, according to common process, clinically acceptable tablet obtained,
Capsule, granule, powder, mixture, pill, solution, syrup, ointment, gelling agent, film, medicinal tea, cataplasm, drink
Material, biscuit, candy, cake food, instant food.
11. the drug that a kind of composition for improving moisture of skin according to claim 1 or 2 improves moisture of skin in preparation
And/or the purposes on health food and/or food.
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| CN111096458B (en) * | 2019-12-31 | 2022-11-01 | 华熙生物科技股份有限公司 | Preparation method and application of hyaluronic acid composition with beauty and health care effects |
| CN116998644A (en) * | 2023-08-03 | 2023-11-07 | 北京彩晔健康管理有限公司 | Edible composition for beautifying and removing freckles and preparation method thereof |
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|---|---|---|---|---|
| CN101111289A (en) * | 2005-01-31 | 2008-01-23 | 株式会社太平洋 | Anti-aging cosmetic composition |
| CN101766294A (en) * | 2008-12-29 | 2010-07-07 | 辽宁兴坤饮品有限公司 | Composite carbonated beverage and preparation method thereof |
| CN102210425A (en) * | 2011-04-11 | 2011-10-12 | 海南京润珍珠生物技术股份有限公司 | Health-care food with function of improving skin moisture |
| CN102743320A (en) * | 2011-04-22 | 2012-10-24 | 上海家化联合股份有限公司 | Application of Boletus edulis extract in cosmetics possessing function for delaying senescence |
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Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101111289A (en) * | 2005-01-31 | 2008-01-23 | 株式会社太平洋 | Anti-aging cosmetic composition |
| CN101766294A (en) * | 2008-12-29 | 2010-07-07 | 辽宁兴坤饮品有限公司 | Composite carbonated beverage and preparation method thereof |
| CN102210425A (en) * | 2011-04-11 | 2011-10-12 | 海南京润珍珠生物技术股份有限公司 | Health-care food with function of improving skin moisture |
| CN102743320A (en) * | 2011-04-22 | 2012-10-24 | 上海家化联合股份有限公司 | Application of Boletus edulis extract in cosmetics possessing function for delaying senescence |
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Address after: 363000 No. 1, Amber Road, Xiangcheng District, Zhangzhou City, Fujian Province Patentee after: ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL Co.,Ltd. Address before: 363000 1 Street, Zhangzhou, Fujian Patentee before: ZHANGZHOU PIEN TZE HUANG PHARMACEUTICAL Co.,Ltd. |