CN105535658A - Traditional Chinese medicine composition for treating dental ulcer and preparation method thereof - Google Patents
Traditional Chinese medicine composition for treating dental ulcer and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
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- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
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- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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Abstract
The invention provides a traditional Chinese medicine composition for treating dental ulcer and a preparation method thereof. The traditional Chinese medicine composition is prepared from, 15-30 parts of honeysuckles, 5-15 parts of lemons, 10-20 parts of cortex phellodendri, 2-12 parts of pseudo-ginsengs, 2-10 parts of borneol, 5-12 parts of bamboo leaves, 10-30 parts of rhizoma atractylodis, 10-20 parts of a capillary wormwood herb, 10-20 parts of plantain, honeylocust thorn 5-12 parts of Chinese honeylocust spine, 10-30 parts of rosa roxbunghii and 5-12 parts of licorice roots. The traditional Chinese medicine composition is prepared through soaking, decoction and other processes and has a good effect of treating the dental ulcer caused by heat toxin stagnation.
Description
Technical field
The present invention relates to field of medicine invention, be specifically related to a kind of treat oral ulcer Chinese medicine composition and preparation method thereof.
Background technology
Oral ulcer, is also called " aphtha ", is the skin ulcer occurred on oral mucosa, large I from the grain of rice to Semen Glycines size, circular or oval, ulcer surface is recessed, congested around, can cause pain because of irritable food.Oral ulcer inducement may be local wound, psychentonia, food, medicine, hormonal readiness change and vitamin or trace element deficiency.Systemic disease, heredity, immunity and microorganism may play an important role in the generation, development of oral ulcer.Current treatment oral ulcer is mainly based on Western medicine antiinflammatory, but Western medicine side effect is larger.
Inventor, in order to solve the misery of oral ulcer patient, finds the medicine little to health side effect, therefore have developed a kind of new drug.
Summary of the invention
The object of this invention is to provide a kind of treat oral ulcer Chinese medicine composition.
Another object of the present invention is to provide a kind of preparation method for the treatment of the Chinese medicine composition of oral ulcer.
Another object of the present invention is to provide Chinese medicine composition described above and pents up application in the medicine of caused oral ulcer at preparation treatment pyretic toxicity.
The invention provides a kind of Chinese medicine composition for the treatment of oral ulcer, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 15-30 part, Fructus Citri Limoniae 5-15 part, Cortex Phellodendri 10-20 part, Radix Notoginseng 2-12 part, Borneolum Syntheticum 2-10 part, Folium Bambusae 5-12 part, Rhizoma Atractylodis 10-30 part, Herba Artemisiae Scopariae 10-20 part, Herba Plantaginis 10-20 part, Spina Gleditsiae 5-12 part, Fructus Rosae Normalis 10-30 part, Radix Glycyrrhizae 5-12 part.
Preferably, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 18-28 part, Fructus Citri Limoniae 7-13 part, Cortex Phellodendri 12-18 part, Radix Notoginseng 4-10 part, Borneolum Syntheticum 4-8 part, Folium Bambusae 7-10 part, Rhizoma Atractylodis 15-25 part, Herba Artemisiae Scopariae 12-18 part, Herba Plantaginis 12-18 part, Spina Gleditsiae 7-10 part, Fructus Rosae Normalis 15-28 part, Radix Glycyrrhizae 7-10 part.
Further preferably, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 20-25 part, Fructus Citri Limoniae 9-12 part, Cortex Phellodendri 14-16 part, Radix Notoginseng 6-8 part, Borneolum Syntheticum 5-7 part, Folium Bambusae 8-9 part, Rhizoma Atractylodis 18-22 part, Herba Artemisiae Scopariae 14-16 part, Herba Plantaginis 14-16 part, Spina Gleditsiae 8-9 part, Fructus Rosae Normalis 18-25 part, Radix Glycyrrhizae 8-9 part.
Further preferably, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 22 parts, 10 parts, Fructus Citri Limoniae, Cortex Phellodendri 15 parts, Radix Notoginseng 7 parts, Borneolum Syntheticum 6 parts, 8 parts, Folium Bambusae, Rhizoma Atractylodis 20 parts, Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 15 parts, Spina Gleditsiae 8 parts, Fructus Rosae Normalis 22 parts, 8 parts, Radix Glycyrrhizae.
Described Chinese medicine composition is also containing pharmaceutically acceptable carrier or diluent.
Described Chinese medicine composition is solid preparation or liquid preparation, and described solid preparation is tablet, capsule, granule or pill; Described liquid preparation is oral liquid.
The method of described Chinese medicine composition comprises the following steps: Flos Lonicerae, Fructus Citri Limoniae, Cortex Phellodendri, Radix Notoginseng, Borneolum Syntheticum, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Spina Gleditsiae, Fructus Rosae Normalis, Radix Glycyrrhizae pulverize and sieve, even with pharmaceutically acceptable carrier or mixing diluents, be prepared into preparation.
Described Fructus Citri Limoniae is Fresh Lemon.
Described Fructus Rosae Normalis is fresh Fructus Rosae Normalis.
Described parts by weight can be the known unit of weights of field of medicaments such as μ g, mg, g, kg.
The implication of times amount refers to the weight ratio of medical material.
Chinese medicine composition provided by the invention is also containing pharmaceutically acceptable carrier or diluent.
Described Chinese medicine composition is solid preparation or liquid preparation, and described solid preparation is tablet, capsule, granule or pill; Described liquid preparation is oral liquid.
Described pharmaceutically acceptable carrier or diluent refer to the pharmaceutical carrier of pharmaceutical field routine, are selected from one or more in filler, binding agent, disintegrating agent, lubricant, surfactant or correctives.
Wherein said filler is selected from starch, sucrose, lactose, mannitol, sorbitol, xylitol, microcrystalline Cellulose or glucose etc.;
Described binding agent is selected from cellulose derivative, alginate, gelatin or polyvinylpyrrolidone etc.;
Described disintegrating agent is selected from microcrystalline Cellulose, carboxymethyl starch sodium, polyvinylpyrrolidone, low-substituted hydroxypropyl cellulose or cross-linking sodium carboxymethyl cellulose;
Described lubricant is selected from stearic acid, Polyethylene Glycol, calcium carbonate, sodium bicarbonate, silicon dioxide, Pulvis Talci or magnesium stearate;
Described surfactant is selected from smooth or Polysorbate (tween) of dodecylbenzene sodium sulfonate, stearic acid, Pluronic F68, fatty acid Pyrusussuriensis etc.;
Described correctives is selected from aspartame, Sucralose or saccharin sodium.
The method of Chinese medicine composition of the present invention comprises the following steps:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 2-5 hour of 10-20 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 1-3 hour for subsequent use.
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heating decoct 1-3 time. each 0.5-1.5 hour, filter, filtrate is concentrated, dry, pulverize into fine powder, for subsequent use.
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added soak by water 1-3 time of 10-30 times amount, each 1-3 hour, filters, and filtrate concentrates, and dry, pulverize into fine powder, for subsequent use.
5) by 3), 4) mixing of the fine powder of step, technique makes the dosage form of pharmaceutical acceptable routinely.
Preferably, the method for described Chinese medicine composition comprises the following steps:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use.
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use.
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use.
5) by 3), 4) mixing of the fine powder of step, technique makes the dosage form of pharmaceutical acceptable routinely.
Chinese medicine composition provided by the invention has the following advantages:
1, act on obvious, rapid-action, have no side effect.
2, the present invention is caused staphylococcus epidermidis by the Chinese medicine composition described in the display of pharmacodynamics test data bacterial canker, scald property and acetic acid oral ulcer have good effect, the function of above-mentioned pharmacodynamic result and Chinese medicine composition of the present invention cures mainly and substantially matches, for further clinical practice provides pharmacology's foundation.
Detailed description of the invention
Following examples for illustration of the present invention, but are not used for limiting the scope of the invention.
Embodiment 1
Prescription: Flos Lonicerae 15 parts, 5 parts, Fructus Citri Limoniae, Cortex Phellodendri 10 parts, Radix Notoginseng 2 parts, Borneolum Syntheticum 2 parts, 5 parts, Folium Bambusae, Rhizoma Atractylodis 10 parts, Herba Artemisiae Scopariae 10 parts, Herba Plantaginis 10 parts, Spina Gleditsiae 5 parts, Fructus Rosae Normalis 10 parts, 5 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 2 hours of 10 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 1 hour for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 1 time. each 0.5 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 1 time of 10 times amount, each 1 hour, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add the starch accounting for mix homogeneously fine powder weight 2/5, incapsulate, make capsule.
Specification: every dress 0.35g.
Embodiment 2
Prescription: Flos Lonicerae 30 parts, 15 parts, Fructus Citri Limoniae, Cortex Phellodendri 20 parts, Radix Notoginseng 12 parts, Borneolum Syntheticum 10 parts, 12 parts, Folium Bambusae, Rhizoma Atractylodis 30 parts, Herba Artemisiae Scopariae 20 parts, Herba Plantaginis 20 parts, Spina Gleditsiae 12 parts, Fructus Rosae Normalis 30 parts, 12 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 5 hours of 20 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 3 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 3 times. each 0.5-1.5 hour, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 3 times of 30 times amount, each 3 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add the starch accounting for mix homogeneously fine powder weight 2/5, incapsulate, make capsule.
Specification: every dress 0.35g.
Embodiment 3
Prescription: Flos Lonicerae 18 parts, 7 parts, Fructus Citri Limoniae, Cortex Phellodendri 12 parts, Radix Notoginseng 4 parts, Borneolum Syntheticum 4 parts, 7 parts, Folium Bambusae, Rhizoma Atractylodis 15 parts, Herba Artemisiae Scopariae 12 parts, Herba Plantaginis 12 parts, Spina Gleditsiae 7 parts, Fructus Rosae Normalis 15 parts, 7 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add the starch accounting for mix homogeneously fine powder weight 1/5, dry, tabletting, obtains the tablet of the application.
Specification: every sheet 0.35g.
Embodiment 4
Prescription: Flos Lonicerae 28 parts, 13 parts, Fructus Citri Limoniae, Cortex Phellodendri 18 parts, Radix Notoginseng 10 parts, Borneolum Syntheticum 8 parts, 10 parts, Folium Bambusae, Rhizoma Atractylodis 25 parts, Herba Artemisiae Scopariae 18 parts, Herba Plantaginis 18 parts, Spina Gleditsiae 10 parts, Fructus Rosae Normalis 28 parts, 10 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add the starch accounting for mix homogeneously fine powder weight 1/5, mixing, granulate, dry, granulate, obtains the granule of the application.
Specification: every packed 0.35g.
Embodiment 5
Prescription: Flos Lonicerae 20 parts, 9 parts, Fructus Citri Limoniae, Cortex Phellodendri 14 parts, Radix Notoginseng 6 parts, Borneolum Syntheticum 5 parts, 8 parts, Folium Bambusae, Rhizoma Atractylodis 18 parts, Herba Artemisiae Scopariae 14 parts, Herba Plantaginis 14 parts, Spina Gleditsiae 8 parts, Fructus Rosae Normalis 18 parts, 8 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add 3 times amount aquesterilisa, filter, add the aspartame accounting for filtrate 1/8, perfusion, gland, sterilizing, obtains the oral liquid of the application.
Specification: every bottle of 5ml.
Embodiment 6
Prescription: Flos Lonicerae 25 parts, 12 parts, Fructus Citri Limoniae, Cortex Phellodendri 16 parts, Radix Notoginseng 8 parts, Borneolum Syntheticum 7 parts, 9 parts, Folium Bambusae, Rhizoma Atractylodis 22 parts, Herba Artemisiae Scopariae 16 parts, Herba Plantaginis 16 parts, Spina Gleditsiae 9 parts, Fructus Rosae Normalis 25 parts, 9 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add the dextrin accounting for mix homogeneously fine powder weight 1/16, mixing, pill, dry, make the micropill of the application.
Specification: every packed 0.45g.
Embodiment 7
Prescription: Flos Lonicerae 22 parts, 10 parts, Fructus Citri Limoniae, Cortex Phellodendri 15 parts, Radix Notoginseng 7 parts, Borneolum Syntheticum 6 parts, 8 parts, Folium Bambusae, Rhizoma Atractylodis 20 parts, Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 15 parts, Spina Gleditsiae 8 parts, Fructus Rosae Normalis 22 parts, 8 parts, Radix Glycyrrhizae.
Preparation method:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, add the vegetable oil mixing accounting for mix homogeneously fine powder weight 1/10, make the soft capsule of the application.
Specification: every dress 0.45g.
In order to prove beneficial effect of the present invention, inventor has done the pharmacology test of oral ulcer.
One, experiment material
1, test medicine: the high, medium and low dosage group of medicine of the present invention, metronidazole, KUIYANG SAN.
2, usage: skin, mucosa delivery.
3, animal: rabbit body weight 2kg, male and female dual-purpose.
4, antibacterial: staphylococcus epidermidis, is clinical strain.
Two, experimental technique
After skin, mucosa delivery, within the corresponding time, observe the impact on bacterial canker, scald property and the acetic acid oral ulcer that rabbit staphylococcus epidermidis causes.
Three, result
Result shows, the present composition obviously can promote the effect that bacterial canker, scald property and acid oral ulcer heal.Refer to table 1, table 2, table 3.
Table 1 medicine of the present invention to rabbit scald property oral ulcer inhibitory action (
n=10)
Compare with blank group:
*p < 0.05,
*p < 0.01; Compare with before self medication,
△p < 0.05,
△ △p < 0.01.
Table 2 medicine of the present invention to rabbit scald property oral ulcer inhibitory action (
n=10)
Compare with blank group:
*p < 0.05,
*p < 0.01; Compare with before self medication,
△p < 0.05,
△ △p < 0.01.
Table 3 medicine of the present invention to the inhibitory action of rabbit acetic acid oral ulcer (
n=10)
Compare with blank group:
*p < 0.05,
*p < 0.01; Compare with before self medication,
△p < 0.05,
△ △p < 0.01.
Four, safety analysis and evaluation
This product is by acute toxicity test, and long term toxicity test result shows: without obvious toxic reaction under this experiment condition.
Sum up: bacterial canker, scald property and acetic acid oral ulcer that the present invention is caused staphylococcus epidermidis by the Chinese medicine composition described in the display of pharmacodynamics test data have good Promotive union effect, the function of above-mentioned pharmacodynamic result and Chinese medicine composition of the present invention cures mainly and substantially matches, for further clinical practice provides pharmacology's foundation.
Although above with general explanation, detailed description of the invention and test, the present invention is described in detail, on basis of the present invention, can make some amendments to it or improve, this will be apparent to those skilled in the art.Therefore, these modifications or improvements without departing from theon the basis of the spirit of the present invention, all belong to the scope of protection of present invention.
Claims (10)
1. treat the Chinese medicine composition of oral ulcer for one kind, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 15-30 part, Fructus Citri Limoniae 5-15 part, Cortex Phellodendri 10-20 part, Radix Notoginseng 2-12 part, Borneolum Syntheticum 2-10 part, Folium Bambusae 5-12 part, Rhizoma Atractylodis 10-30 part, Herba Artemisiae Scopariae 10-20 part, Herba Plantaginis 10-20 part, Spina Gleditsiae 5-12 part, Fructus Rosae Normalis 10-30 part, Radix Glycyrrhizae 5-12 part.
2. Chinese medicine composition according to claim 1, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 18-28 part, Fructus Citri Limoniae 7-13 part, Cortex Phellodendri 12-18 part, Radix Notoginseng 4-10 part, Borneolum Syntheticum 4-8 part, Folium Bambusae 7-10 part, Rhizoma Atractylodis 15-25 part, Herba Artemisiae Scopariae 12-18 part, Herba Plantaginis 12-18 part, Spina Gleditsiae 7-10 part, Fructus Rosae Normalis 15-28 part, Radix Glycyrrhizae 7-10 part.
3. Chinese medicine composition according to claim 2, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 20-25 part, Fructus Citri Limoniae 9-12 part, Cortex Phellodendri 14-16 part, Radix Notoginseng 6-8 part, Borneolum Syntheticum 5-7 part, Folium Bambusae 8-9 part, Rhizoma Atractylodis 18-22 part, Herba Artemisiae Scopariae 14-16 part, Herba Plantaginis 14-16 part, Spina Gleditsiae 8-9 part, Fructus Rosae Normalis 18-25 part, Radix Glycyrrhizae 8-9 part.
4. Chinese medicine composition according to claim 3, it is characterized in that, this Chinese medicine composition is made up of the Chinese medicine of following weight portion: Flos Lonicerae 22 parts, 10 parts, Fructus Citri Limoniae, Cortex Phellodendri 15 parts, Radix Notoginseng 7 parts, Borneolum Syntheticum 6 parts, 8 parts, Folium Bambusae, Rhizoma Atractylodis 20 parts, Herba Artemisiae Scopariae 15 parts, Herba Plantaginis 15 parts, Spina Gleditsiae 8 parts, Fructus Rosae Normalis 22 parts, 8 parts, Radix Glycyrrhizae.
5. the Chinese medicine composition according to any one of claim 1-4, is characterized in that, this Chinese medicine composition is also containing pharmaceutically acceptable carrier or diluent.
6. Chinese medicine composition according to claim 5, is characterized in that, described Chinese medicine composition is solid preparation or liquid preparation, and described solid preparation is tablet, capsule, granule or pill; Described liquid preparation is oral liquid.
7. prepare the method for the Chinese medicine composition described in any one of claim 1-4 for one kind, it is characterized in that, the method comprises the following steps: Flos Lonicerae, Fructus Citri Limoniae, Cortex Phellodendri, Radix Notoginseng, Borneolum Syntheticum, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Spina Gleditsiae, Fructus Rosae Normalis, Radix Glycyrrhizae pulverize and sieve, even with pharmaceutically acceptable carrier or mixing diluents, be prepared into preparation.
8. prepare a method for the Chinese medicine composition described in any one of claim 1-4, it is characterized in that, the method comprises the following steps:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 2-5 hour of 10-20 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 1-3 hour for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heating decoct 1-3 time. each 0.5-1.5 hour, filter, filtrate is concentrated, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added soak by water 1-3 time of 10-30 times amount, each 1-3 hour, filters, and filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, technique makes the dosage form of pharmaceutical acceptable routinely.
9. the method for Chinese medicine composition according to claim 8, is characterized in that, the method comprises the following steps:
1) various medical material is taken by proportioning for subsequent use;
2) Fructus Citri Limoniae, Fructus Rosae Normalis are added the water soaking 3 hours of 15 times amount, squeeze the juice, filter, filtrate add Borneolum Syntheticum soak 2 hours for subsequent use;
3) Cortex Phellodendri, Radix Notoginseng, Spina Gleditsiae are added step 2) filtrate in heat decoction 2 times. each 1 hour, filter, filtrate concentrate, dry, pulverize into fine powder, for subsequent use;
4) Flos Lonicerae, Folium Bambusae, Rhizoma Atractylodis, Herba Artemisiae Scopariae, Herba Plantaginis, Radix Glycyrrhizae are added the soak by water 2 times of 20 times amount, each 2 hours, filter, filtrate concentrates, and dry, pulverize into fine powder, for subsequent use;
5) by 3), 4) mixing of the fine powder of step, technique makes the dosage form of pharmaceutical acceptable routinely.
10. the Chinese medicine composition described in any one of claim 1-4 pents up the application in the medicine of caused oral ulcer at preparation treatment pyretic toxicity.
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| CN201610094680.7A CN105535658A (en) | 2016-02-16 | 2016-02-16 | Traditional Chinese medicine composition for treating dental ulcer and preparation method thereof |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721276A (en) * | 2019-11-29 | 2020-01-24 | 成都中医药大学 | A traditional Chinese medicine chewing gum for preventing and/or treating oral ulcers |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919268A (en) * | 2006-08-19 | 2007-02-28 | 袁爱仙 | Mouth-wash medicine for treating stomatocace and preparation method thereof |
-
2016
- 2016-02-16 CN CN201610094680.7A patent/CN105535658A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1919268A (en) * | 2006-08-19 | 2007-02-28 | 袁爱仙 | Mouth-wash medicine for treating stomatocace and preparation method thereof |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110721276A (en) * | 2019-11-29 | 2020-01-24 | 成都中医药大学 | A traditional Chinese medicine chewing gum for preventing and/or treating oral ulcers |
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Application publication date: 20160504 |