CN105456312A - Screwtree root tea effervescent tablet and preparation method thereof - Google Patents
Screwtree root tea effervescent tablet and preparation method thereof Download PDFInfo
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- CN105456312A CN105456312A CN201510903427.7A CN201510903427A CN105456312A CN 105456312 A CN105456312 A CN 105456312A CN 201510903427 A CN201510903427 A CN 201510903427A CN 105456312 A CN105456312 A CN 105456312A
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- agent
- tea
- radix helicteris
- tablet
- effervescent
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- 241001122767 Theaceae Species 0.000 title claims abstract 20
- 239000007938 effervescent tablet Substances 0.000 title claims abstract 8
- 238000002360 preparation method Methods 0.000 title claims abstract 7
- 241000933211 Helicteres jamaicensis Species 0.000 title abstract 9
- 239000003795 chemical substances by application Substances 0.000 claims abstract 28
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract 15
- 239000000843 powder Substances 0.000 claims abstract 12
- 239000000284 extract Substances 0.000 claims abstract 10
- 239000000945 filler Substances 0.000 claims abstract 8
- 239000000314 lubricant Substances 0.000 claims abstract 8
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims abstract 6
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims abstract 6
- 229930006000 Sucrose Natural products 0.000 claims abstract 5
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims abstract 5
- 239000000203 mixture Substances 0.000 claims abstract 4
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims abstract 3
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims abstract 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract 3
- 229920002472 Starch Polymers 0.000 claims abstract 3
- FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims abstract 3
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims abstract 3
- 229960004543 anhydrous citric acid Drugs 0.000 claims abstract 3
- 229960004106 citric acid Drugs 0.000 claims abstract 3
- 239000008101 lactose Substances 0.000 claims abstract 3
- 239000001630 malic acid Substances 0.000 claims abstract 3
- 235000011090 malic acid Nutrition 0.000 claims abstract 3
- 229940099690 malic acid Drugs 0.000 claims abstract 3
- 238000002156 mixing Methods 0.000 claims abstract 3
- HWPKGOGLCKPRLZ-UHFFFAOYSA-M monosodium citrate Chemical compound [Na+].OC(=O)CC(O)(C([O-])=O)CC(O)=O HWPKGOGLCKPRLZ-UHFFFAOYSA-M 0.000 claims abstract 3
- TZBAVQKIEKDGFH-UHFFFAOYSA-N n-[2-(diethylamino)ethyl]-1-benzothiophene-2-carboxamide;hydrochloride Chemical compound [Cl-].C1=CC=C2SC(C(=O)NCC[NH+](CC)CC)=CC2=C1 TZBAVQKIEKDGFH-UHFFFAOYSA-N 0.000 claims abstract 3
- 229910000030 sodium bicarbonate Inorganic materials 0.000 claims abstract 3
- 235000017557 sodium bicarbonate Nutrition 0.000 claims abstract 3
- 229910000029 sodium carbonate Inorganic materials 0.000 claims abstract 3
- 239000008107 starch Substances 0.000 claims abstract 3
- 235000019698 starch Nutrition 0.000 claims abstract 3
- 239000011975 tartaric acid Substances 0.000 claims abstract 3
- 235000002906 tartaric acid Nutrition 0.000 claims abstract 3
- 229960001367 tartaric acid Drugs 0.000 claims abstract 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 239000003826 tablet Substances 0.000 claims 5
- 102000004169 proteins and genes Human genes 0.000 claims 4
- 108090000623 proteins and genes Proteins 0.000 claims 4
- 239000005720 sucrose Substances 0.000 claims 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 3
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 claims 2
- WBZFUFAFFUEMEI-UHFFFAOYSA-M Acesulfame k Chemical compound [K+].CC1=CC(=O)[N-]S(=O)(=O)O1 WBZFUFAFFUEMEI-UHFFFAOYSA-M 0.000 claims 2
- 108010011485 Aspartame Proteins 0.000 claims 2
- 235000006679 Mentha X verticillata Nutrition 0.000 claims 2
- 235000002899 Mentha suaveolens Nutrition 0.000 claims 2
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims 2
- 240000008790 Musa x paradisiaca Species 0.000 claims 2
- 235000018290 Musa x paradisiaca Nutrition 0.000 claims 2
- UEDUENGHJMELGK-HYDKPPNVSA-N Stevioside Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@]12C(=C)C[C@@]3(C1)CC[C@@H]1[C@@](C)(CCC[C@]1([C@@H]3CC2)C)C(=O)O[C@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UEDUENGHJMELGK-HYDKPPNVSA-N 0.000 claims 2
- 235000010358 acesulfame potassium Nutrition 0.000 claims 2
- 229960004998 acesulfame potassium Drugs 0.000 claims 2
- 239000000619 acesulfame-K Substances 0.000 claims 2
- 239000000605 aspartame Substances 0.000 claims 2
- 235000010357 aspartame Nutrition 0.000 claims 2
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 claims 2
- 229960003438 aspartame Drugs 0.000 claims 2
- 229940109275 cyclamate Drugs 0.000 claims 2
- HCAJEUSONLESMK-UHFFFAOYSA-N cyclohexylsulfamic acid Chemical compound OS(=O)(=O)NC1CCCCC1 HCAJEUSONLESMK-UHFFFAOYSA-N 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229940093429 polyethylene glycol 6000 Drugs 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- 229940085605 saccharin sodium Drugs 0.000 claims 2
- 206010013786 Dry skin Diseases 0.000 claims 1
- 244000000231 Sesamum indicum Species 0.000 claims 1
- 235000003434 Sesamum indicum Nutrition 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 230000006837 decompression Effects 0.000 claims 1
- 238000007907 direct compression Methods 0.000 claims 1
- 238000001035 drying Methods 0.000 claims 1
- 238000000605 extraction Methods 0.000 claims 1
- 239000000706 filtrate Substances 0.000 claims 1
- 239000011812 mixed powder Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 238000004064 recycling Methods 0.000 claims 1
- -1 reflux Substances 0.000 claims 1
- 239000007921 spray Substances 0.000 claims 1
- 238000003756 stirring Methods 0.000 claims 1
- 239000006228 supernatant Substances 0.000 claims 1
- 239000002253 acid Substances 0.000 abstract 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical group OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 abstract 1
- 235000013681 dietary sucrose Nutrition 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 229960003511 macrogol Drugs 0.000 abstract 1
- 235000018342 monosodium citrate Nutrition 0.000 abstract 1
- 239000002524 monosodium citrate Substances 0.000 abstract 1
- 229960004793 sucrose Drugs 0.000 abstract 1
Classifications
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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- A61K9/0007—Effervescent
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- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61K2236/30—Extraction of the material
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- A61K2236/50—Methods involving additional extraction steps
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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Abstract
The invention discloses a screwtree root tea effervescent tablet and a preparation method of the screwtree root tea effervescent tablet. The screwtree root tea effervescent tablet is prepared from the following components in parts by weight: 1-5 parts of screwtree root tea extract powder, 1-10 parts of a filling agent, 5-20 parts of a disintegrating agent, and 0.2-1 part of a lubricating agent, wherein the filling agent is selected from one or more of lactose, water-soluble starch and saccharose; the disintegrating agent is the composition of an acid agent and an alkaline agent at the weight ratio of 2 to 1, the acid agent is selected from one or more of tartaric acid, malic acid, anhydrous citric acid, citric acid and monosodium citrate, and the alkaline agent is selected from one or more of sodium carbonate and sodium bicarbonate; and the lubricating agent is macrogol 6000 or macrogol 4000. The screwtree root tea effervescent tablet is prepared by mixing all the components according to the amounts in the formula. The screwtree root tea effervescent tablet is convenient to use, the medicinal activity of screwtree root is reserved to the great extent, and the screwtree root tea effervescent tablet is very easy to absorb.
Description
Technical field
The invention belongs to food processing technology field, be specifically related to a kind of Radix Helicteris effervescent tea tablet and preparation method thereof.
Background technology
Radix Helicteris tea is a kind of folks of china tradition beverage, one of herbal tea that Cantonese often drinks, and Radix Helicteris tea is a kind of folks of china tradition beverage, and one of herbal tea that Cantonese often drinks, Radix Helicteris has heat clearing away of inducing sweat, effect of subduing swelling and detoxicating.May be used for cold, fever, headache, thirsty, mumps, measles, dysentery, enteritis, carbuncle, scrofula, sore, eczema, the diseases such as hemorrhoid.
At present, the use for Radix Helicteris tea generally still rests on traditional herbal tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of Flos Lonicerae is obviously reduced simultaneously, greatly hinders the promotion and application of Radix Helicteris tea.Therefore, at present in the urgent need to providing a kind of Radix Helicteris tea health beverage of conveniently drinking, to adapt to the demand of consumers in general, significantly promoted the quality of life of people.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium bicarbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after water put into by effervescent tablet, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegrate of tablet and thawing, and the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as soda pop when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Herbal tea is as Chinese tradition beverage, and the herbal tea paving big and small in In Guangdong Province is seen everywhere, and pouplarity has some idea of.But traditional herb tea decocts to waste time and energy, the rhythm of life of urbanite is but more and more faster now, and younger generation few people are ready to buy specially a clay pot and spend several hours and go decoction one to take herbal tea.Therefore, effervescent tablet preparation formulation and traditional herb tea are organically combined, are convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
Summary of the invention
Use habit for current herbal tea of the present invention, proposes a kind of novel Radix Helicteris effervescent tea tablet, solves the technological deficiency that traditional Radix Helicteris tea is loaded down with trivial details, consuming time in use.
Another object of the present invention is to the preparation method that described Radix Helicteris effervescent tea tablet is provided.
The present invention realizes especially by following technical scheme:
A kind of Radix Helicteris effervescent tea tablet, comprises following component: 1 ~ 5 part, Radix Helicteris tea extract powder, filler 1 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part by weight.
Wherein said filler is selected from one or more in lactose, water soluble starch or sucrose.
Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.
Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
Described Radix Helicteris tea extract powder is prepared by the following method:
After dry Radix Helicteris tea merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Sweeting agent 1-2%, aromatic 0.5-0.8% also can be comprised by mass content in Radix Helicteris effervescent tea tablet of the present invention.Sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
Another object of the present invention is to the preparation method that a kind of sesame seed tea effervescent tablet is provided, specifically comprise the following steps:
1) preparation of Radix Helicteris tea extract powder;
2) following component is taken by recipe quantity: 1 ~ 5 part, Radix Helicteris tea extract powder, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part;
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Sweeting agent pulverized 100 ~ 120 mesh sieves, and 140 ~ 200 mesh sieves pulverized by lubricant, and filler pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator;
4) Sang Ju Yin extract powder is mixed with sour agent, sweeting agent can be added again or aromatic mix homogeneously obtains powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing;
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix;
6) by gained mixed-powder direct compression, required Radix Helicteris effervescent tea tablet is obtained.
Further, described filler is selected from one or more in lactose, water soluble starch or sucrose.
Described sour agent and alkaline agent weight ratio are 2:1, and described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.
Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
Described Radix Helicteris tea extract powder is prepared by the following method:
After dry Radix Helicteris tea merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Described sweeting agent and aromatic account for 1-2% and 0.5-0.8% of raw material total amount, sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
Beneficial effect of the present invention is:
1, effectively remain the medicinal active ingredient of Radix Helicteris, improve its utilization rate.
2, disintegration of Radix Helicteris effervescent tea tablet that this formula and preparation method obtain can reach 105s, solve the slow difficult problem of Effervescent tablet disintegration, screening by the proportioning to Radix Helicteris effervescent tea tablet and the screening to gas-producing disintegrant and lubricant etc., make Radix Helicteris effervescent tea tablet of the present invention obtain best effervescent effect.
The present invention makes effervescent tablet traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.The Radix Helicteris effervescent tea tablet that the present invention prepares has the effect of certain hypertension.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
Radix Helicteris is a kind of folks of china tradition beverage, one of herbal tea that Cantonese often drinks, use for Radix Helicteris generally still rests on traditional herbal tea and decocts, use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of Radix Helicteris is obviously reduced simultaneously, greatly hinder the promotion and application of Radix Helicteris.The present invention organically combines effervescent tablet preparation formulation and traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
The invention provides Radix Helicteris effervescent tea tablet, comprise following component by weight: 1 ~ 5 part, Radix Helicteris tea extract powder, filler 0 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part.Wherein said filler is selected from one or more in lactose, water soluble starch or sucrose.Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
Sweeting agent 1-2%, aromatic 0.5-0.8% also can be comprised by mass content in Radix Helicteris effervescent tea tablet of the present invention.Sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
Present invention also offers a kind of preparation method of sesame seed tea effervescent tablet, specifically comprise the following steps:
1) preparation of Radix Helicteris tea extract powder:
After dry Radix Helicteris tea merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
2) following component is taken by recipe quantity: 1 ~ 5 part, Radix Helicteris tea extract powder, filler 0 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part; Described filler is selected from one or more in lactose, water soluble starch or sucrose.Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.
3) by disintegrating agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Sweeting agent pulverized 100 ~ 120 mesh sieves, and 140 ~ 200 mesh sieves pulverized by lubricant, and filler pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator; Wherein sweeting agent can be selected from one or more in cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium).
4) Sang Ju Yin extract powder is mixed with sour agent, sweeting agent can be added again or aromatic mix homogeneously obtains powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing.
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required Radix Helicteris effervescent tea tablet.
Embodiment 1
A kind of Radix Helicteris effervescent tea tablet, prepares especially by following steps:
After broken for dry Radix Helicteris tea powder rear merceration 0.5h, add 10 ~ 13 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 80 DEG C, extraction time is 2 times, the solid-liquid ratio of reflux, extract, is 1:13 for the first time, second time reflux, extract, solid-liquid ratio is 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: 1 part, Radix Helicteris tea extract powder, lactose 5 parts, 4 parts, tartaric acid, sodium bicarbonate 2 parts, polyethylene glycol 6000 0.1 part by recipe quantity; By tartaric acid and sodium bicarbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Polyethylene glycol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in exsiccator; Sang Ju Yin extract powder and tartaric acid are mixed to get powders A; Powder B is obtained by sodium bicarbonate with lactose Homogeneous phase mixing; Add polyethylene glycol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required Radix Helicteris effervescent tea tablet.
Embodiment 2
A kind of Radix Helicteris effervescent tea tablet, prepares especially by following steps:
After broken for dry Radix Helicteris tea powder rear merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 75 DEG C, extraction time is 3 times, the solid-liquid ratio of reflux, extract, is 1:15 for the first time, second time and for the third time reflux, extract, solid-liquid ratio are 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: 5 parts, Radix Helicteris tea extract powder, water soluble starch 10 parts, citric acid 13 parts, sodium bicarbonate 7 parts, Macrogol 4000 1 part by recipe quantity; By citric acid and sodium bicarbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 4000 pulverized 140 ~ 200 mesh sieves, and water soluble starch pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator; Sang Ju Yin extract powder and citric acid are mixed to get powders A; Powder B is obtained by sodium bicarbonate with water soluble starch Homogeneous phase mixing; Add Macrogol 4000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required Radix Helicteris effervescent tea tablet.
Embodiment 3
A kind of Radix Helicteris effervescent tea tablet, prepares especially by following steps:
After broken for dry Radix Helicteris tea powder rear merceration 0.5h, add 10 ~ 14 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 85 DEG C, extraction time is 3 times, the solid-liquid ratio of reflux, extract, is 1:14 for the first time, second time and for the third time reflux, extract, solid-liquid ratio are 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: 3 parts, Radix Helicteris tea extract powder, sucrose 5 parts, malic acid 8 parts, sodium carbonate 4 parts, Macrogol 4000 0.2 part by recipe quantity; By malic acid and sodium carbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 4000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by sucrose, saved backup in exsiccator; Sang Ju Yin extract powder and malic acid are mixed to get powders A; Powder B is obtained by sodium carbonate with sucrose Homogeneous phase mixing; Add Macrogol 4000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required Radix Helicteris effervescent tea tablet.
Embodiment 4
A kind of Radix Helicteris effervescent tea tablet, prepares especially by following steps:
After broken for dry Radix Helicteris tea powder rear merceration 0.5h, add 10 ~ 12 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 85 DEG C, extraction time is 3 times, the solid-liquid ratio of reflux, extract, is 1:12 for the first time, second time and for the third time reflux, extract, solid-liquid ratio are 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: 3 parts, Radix Helicteris tea extract powder, sucrose 1 part, 10 parts, tartaric acid, sodium carbonate 5 parts, polyethylene glycol 6000 0.6 part by recipe quantity; By tartaric acid and sodium carbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Polyethylene glycol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by sucrose, saved backup in exsiccator; Sang Ju Yin extract powder and tartaric acid are mixed to get powders A; Powder B is obtained by sodium carbonate with sucrose Homogeneous phase mixing; Add polyethylene glycol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required Radix Helicteris effervescent tea tablet.
Embodiment 5
A kind of Radix Helicteris effervescent tea tablet, prepares especially by following steps:
After broken for dry Radix Helicteris tea powder rear merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 70 DEG C, extraction time is 2 times, the solid-liquid ratio of reflux, extract, is 1:15 for the first time, second time reflux, extract, solid-liquid ratio is 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: 4 parts, Radix Helicteris tea extract powder, lactose 4 parts, anhydrous citric acid 12 parts, sodium carbonate 6 parts, polyethylene glycol 6000 0.3 part by recipe quantity; By anhydrous citric acid and sodium carbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Polyethylene glycol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in exsiccator; Sang Ju Yin extract powder and anhydrous citric acid are mixed to get powders A; Powder B is obtained by sodium carbonate with lactose Homogeneous phase mixing; Add polyethylene glycol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required Radix Helicteris effervescent tea tablet.
Comparative example
Below in conjunction with disintegration, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the granule assembled.No longer include gas to solution to overflow and the time difference T (s) dissolved is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind method " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
The routine patient of clinical observation 60, treatment group 30 example, matched group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes Radix Helicteris effervescent tea tablet sheet one week.
Diagnosis basis: disconnected standard is based on the standard of anemopyretic cold card relevant in " disease of tcm Standardization of diagnosis and curative effect ", and 1. heating, micro evil wind are trembled with fear, have a stuffy nose watery nasal discharge, sneeze, headache, general malaise.2. light red tongue or limit point red, platform book is yellow, floating and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, general pain, watery nasal discharge, pharyngalgia, pharyngeal congestion, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet the diagnostic criteria of traditional Chinese medical science anemopyretic cold card, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of pulmonary, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be trimester of pregnancy, women breast-feeding their children, and body constitution allergy sufferers.
Matched group: conventional Radix Helicteris tea.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Therapeutic outcome: in table 2.
The quality evaluation of table 1 Radix Helicteris tea of the present invention drop pill
| Disintegration (s) | Sensory evaluation scores (dividing) | Hardness (N) | |
| Embodiment 1 | 105s | 100 | 62N |
| Embodiment 2 | 148s | 98 | 64N |
| Embodiment 3 | 136s | 85 | 65N |
| Embodiment 4 | 118s | 90 | 67N |
| Embodiment 5 | 110s | 95 | 60N |
| Comparative example | 445s | 38 | 63N |
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
| Group | Total number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 30 | 26 | 3 | 1 | 1 | 89.7％ |
| Embodiment 2 | 30 | 22 | 2 | 2 | 4 | 86.7％ |
| Embodiment 3 | 30 | 16 | 6 | 5 | 3 | 90％ |
| Embodiment 4 | 30 | 18 | 5 | 2 | 5 | 83.3％ |
| Embodiment 5 | 30 | 21 | 3 | 2 | 4 | 86.7％ |
| Comparative example | 30 | 6 | 4 | 5 | 15 | 50％ |
As shown in Table 2, effervescent tablet of the present invention treatment anemopyretic cold effect higher than existing Radix Helicteris tea, illustrates effervescent tablet of the present invention very degree remain the medical active of Radix Helicteris, while more easily played absorption by people, have the advantages that utilization rate is high.
1.2 hypertension effect experiments
Sample liquid made by Example 1 ~ 5 medicine respectively, to normal rat oral gavage administration.
Result of the test shows: embodiment 1 ~ 5 all has obvious hypotensive effect, the ceiling effect time to be about after medication 2 ~ 3 hours, persistent period is more than 4.5 hours, systolic pressure/diastolic pressure declines 15%/17%, 17%/20%, 10%/12%, 21%/23% respectively, all there is significant difference (P < 0.05, P < 0.01) compared with before administration.
Similarly, renal hypertensive rat is tested, result shows: embodiment 1 ~ 6 reduces the effect of systolic pressure and diastolic pressure compared with before administration, significant difference (P < 0.05), namely administration was shown in obvious pressure reduction effect the same day, systolic pressure and the diastolic pressure range of decrease all reach 25% and 30%, before 10 days blood pressures of stopping using all are not back to administration.
Visible drop pill hypotensive effect of the present invention is obvious, stable, is used for the treatment of antihypertensive effect remarkable.
1., according to the inventive method, the application manually produces 150 batches of Radix Helicteris effervescent tea tablets altogether, conforming product rate 100%;
2. according to national standard, 24 months Radix Helicteris effervescent tea tablet effect duration, the applicant's reserved sample observing to 36 month, every quality index has not yet to see obvious change;
3. embodiment 1-5 and comparative example illustrate and the invention solves the slow difficult problem of Effervescent tablet disintegration, the screening by the proportioning to Radix Helicteris tea and the screening to gas-producing disintegrant and lubricant etc., make Radix Helicteris effervescent tea tablet of the present invention obtain best effervescent effect;
4. can be found out by above-mentioned result of the test, it is fast that Radix Helicteris effervescent tea tablet of the present invention has disintegrate compared with prior art products, and good stability, the advantages such as weight differential is little, can provide more stable, effective, safe product for patient.
5. the Radix Helicteris effervescent tablet prepared 3 batches, smooth appearance, uniform color, sweet and sour taste, this stable process conditions of experiment results proved is feasible.
Claims (7)
1. a Radix Helicteris effervescent tea tablet, is characterized in that, comprises following component by weight: 1 ~ 5 part, Radix Helicteris tea extract powder, filler 1 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part; Described filler is selected from one or more in lactose, water soluble starch or sucrose; Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate; Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
2. a kind of Radix Helicteris effervescent tea tablet according to claim 1, it is characterized in that, described Radix Helicteris tea extract powder is prepared by the following method: after dry Radix Helicteris tea merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
3. a kind of Radix Helicteris effervescent tea tablet according to claim 1, is characterized in that, also can comprise sweeting agent 1-2%, aromatic 0.5-0.8% in Radix Helicteris effervescent tea tablet of the present invention by mass content; Sweeting agent be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
4. a preparation method for sesame seed tea effervescent tablet, is characterized in that, comprises the following steps:
1) preparation of Radix Helicteris tea extract powder;
2) following component is taken by recipe quantity: 1 ~ 5 part, Radix Helicteris tea extract powder, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part;
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Sweeting agent pulverized 100 ~ 120 mesh sieves, and 140 ~ 200 mesh sieves pulverized by lubricant, and filler pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator;
4) Sang Ju Yin extract powder is mixed with sour agent, then add sweeting agent or aromatic mix homogeneously obtains powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing;
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix;
6) by gained mixed-powder direct compression, required Radix Helicteris effervescent tea tablet is obtained.
5. preparation method according to claim 4, is characterized in that,
Described filler is selected from one or more in lactose, water soluble starch or sucrose;
Described sour agent and alkaline agent weight ratio are 2:1, and described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate;
Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
6. preparation method according to claim 4, is characterized in that, described Radix Helicteris tea extract powder is prepared by method described in claim 2.
7. preparation method according to claim 4, it is characterized in that, described sweeting agent and aromatic account for 1-2% and 0.5-0.8% of raw material total amount, sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425413A (en) * | 2002-12-27 | 2003-06-25 | 中山大学 | Xiasangju effervescent tablet and its preparing process |
| CN1698664A (en) * | 2004-05-21 | 2005-11-23 | 江西本草天工科技有限责任公司 | Isatic root effervescence tablet and preparation method thereof |
| CN104705763A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Sangju effervescent tablet |
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2015
- 2015-12-08 CN CN201510903427.7A patent/CN105456312A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425413A (en) * | 2002-12-27 | 2003-06-25 | 中山大学 | Xiasangju effervescent tablet and its preparing process |
| CN1698664A (en) * | 2004-05-21 | 2005-11-23 | 江西本草天工科技有限责任公司 | Isatic root effervescence tablet and preparation method thereof |
| CN104705763A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Sangju effervescent tablet |
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| Title |
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| 尹福伦 等: "《商海竞辉——玉林市个体私营经济要览》", 31 December 1995, 广西人民出版社 * |
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