CN105456224A - Seasonal cold treating tea effervescent tablet and preparation method thereof - Google Patents
Seasonal cold treating tea effervescent tablet and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0007—Effervescent
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23F—COFFEE; TEA; THEIR SUBSTITUTES; MANUFACTURE, PREPARATION, OR INFUSION THEREOF
- A23F3/00—Tea; Tea substitutes; Preparations thereof
- A23F3/34—Tea substitutes, e.g. matè; Extracts or infusions thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/53—Liquid-solid separation, e.g. centrifugation, sedimentation or crystallization
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
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Abstract
The invention discloses a seasonal cold treating tea effervescent tablet and a preparation method thereof. The effervescent tablet consists of the following components in parts by weight: 1-5 parts of extract powder of seasonal cold treating tea, 1-10 parts of a filling agent, 5-20 parts of a disintegrating agent and 0.2-1 part of a lubricating agent, wherein the filling agent is selected from one or more of lactose, water-soluble starch and sucrose; the disintegrating agent is a composition of an acid agent and an alkaline agent at the weight ratio of 2 to 1; the acid agent is selected from one or more of tartaric acid, malic acid, anhydrous citric acid, citric acid or monosodium citrate; the alkaline agent is selected from one or more of sodium carbonate or sodium bicarbonate; and the lubricating agent is selected from polyethylene glycol 6000 or polyethylene glycol 4000. The effervescent tablet is prepared by mixing the various components according to formulated amounts. The effervescent tablet disclosed by the invention is convenient use and is easier to absorb, and the medicinal activity of the seasonal cold treating tea is reserved to a great extent.
Description
Technical field
The invention belongs to health food processing technique field, be specifically related to a kind of pestilent cold effervescent tea tablet and preparation method thereof.
Background technology
Herbal tea, is also Herb juice or BAICAO tea, is a kind of a kind of beverage popular at southern china (ground such as Guangdong, Fujian), the beverage combined from the hands-down medicinal herbs in multiple location of drawing materials; Because the south of the Five Ridges that Guangdong is located in, heat, wets rainyly, and from ancient times have miasma more; Therefore among the people popular cold and cool with the property of medicine, the Chinese herbal medicine of functions of relieving summer heat, antithermic, endures water to drink, and is called " herbal tea " miscellaneous.At present, the use for tea for common cold generally still rests on traditional herbal tea and decocts, and use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of Herba Pogostemonis etc. is obviously reduced simultaneously, greatly hinders the promotion and application of tea for common cold.Therefore, at present in the urgent need to providing a kind of tea for common cold health beverage of conveniently drinking, to adapt to the demand of consumers in general, significantly promoted the quality of life of people.
Effervescent tablet is a kind of tablet containing gas-producing disintegrant.The mixture of so-called gas-producing disintegrant normally organic acid and sodium carbonate, sodium bicarbonate (sodium bicarbonate); The dry moisture-free of effervescent tablet itself, two kinds of materials in gas-producing disintegrant are unionized can not react; But after water put into by effervescent tablet, two kinds of material generation acid-base reactions, produce great amount of carbon dioxide, make the rapid disintegrate of tablet and thawing, and the bubble that disintegrate sometimes produces also can make tablet roll up and down in water, accelerates its disintegrate and thawing.The carbon dioxide produced during disintegration of tablet is partially dissolved in drinking-water, has the aesthetic feeling as soda pop when drinking-water is drunk in entrance.At present, effervescent tablet is at home and abroad widely used, and common are oral effervescent tablet, vagina effervescence; Have also appeared Traditional Chinese medicine foot-bath effervescent tablet etc. in recent years.
Herbal tea is as Chinese tradition beverage, and the herbal tea paving big and small in In Guangdong Province is seen everywhere, and pouplarity has some idea of.But traditional herb tea decocts to waste time and energy, the rhythm of life of urbanite is but more and more faster now, and younger generation few people are ready to buy specially a clay pot and spend several hours and go decoction one to take herbal tea.Therefore, effervescent tablet preparation formulation and traditional herb tea are organically combined, effervescent tablet preparation formulation is used for, in traditional herb tea, having easy to use; Its stability is increased after the volatile medicine of oxidizable and tool in herbal tea is dissolved in substrate; Mask the taste of herbal tea simultaneously, be more suitable for child, old man and working clan use.Be convenient to produce and carry simultaneously, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
Summary of the invention
Use habit for current herbal tea of the present invention, proposes a kind of novel pestilent cold effervescent tea tablet, solves the technological deficiency that traditional tea for common cold is loaded down with trivial details, consuming time in use.
The present invention realizes especially by following technical scheme:
A novel pestilent cold effervescent tea tablet, comprises following component by weight: tea for common cold extract powder 1 ~ 5 part, filler 1 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part.
Wherein said filler is selected from one or more in lactose, water soluble starch or sucrose.
Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.
Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
Described tea for common cold extract powder is prepared by the following method:
After dry tea for common cold merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Sweeting agent 1-2%, aromatic 0.5-0.8% also can be comprised by mass content in pestilent cold effervescent tea tablet of the present invention.Sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
Another object of the present invention is to the preparation method that a kind of pestilent cold effervescent tea tablet is provided, specifically comprise the following steps:
1) preparation of tea for common cold extract powder;
2) following component is taken by recipe quantity: tea for common cold extract powder 1 ~ 5 part, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part;
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Sweeting agent pulverized 100 ~ 120 mesh sieves, and 140 ~ 200 mesh sieves pulverized by lubricant, and filler pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator;
4) Sang Ju Yin extract powder is mixed with sour agent, sweeting agent can be added again or aromatic mix homogeneously obtains powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing;
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix;
6) by gained mixed-powder direct compression, required pestilent cold effervescent tea tablet is obtained.
Further, described filler is selected from one or more in lactose, water soluble starch or sucrose.
Described sour agent and alkaline agent weight ratio are 2:1, and described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.
Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
Described tea for common cold extract powder is prepared by the following method:
After dry tea for common cold merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Described sweeting agent and aromatic account for 1-2% and 0.5-0.8% of raw material total amount, sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
Beneficial effect of the present invention is: pestilent cold effervescent tea tablet of the present invention has easy to use; Its stability is increased after the volatile medicine of oxidizable and tool in herbal tea is dissolved in substrate; Mask the taste of herbal tea simultaneously, be more suitable for child, old man and working clan use.
The present invention makes effervescent tablet traditional herb tea, be convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
Detailed description of the invention
Below in conjunction with embodiment, the present invention is described further, the following stated, only to preferred embodiment of the present invention, not do other forms of restriction to the present invention, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed to the Equivalent embodiments of equal change.Everyly do not depart from the present invention program's content, any simple modification done following examples according to technical spirit of the present invention or equivalent variations, all drop in protection scope of the present invention.
Tea for common cold is a kind of folks of china tradition beverage, one of herbal tea that Cantonese often drinks, use for tea for common cold generally still rests on traditional herbal tea and decocts, use procedure is consuming time, loaded down with trivial details, owing to decocting for a long time, the medicinal efficacy of tea for common cold is obviously reduced simultaneously, greatly hinder the promotion and application of tea for common cold.Effervescent tablet preparation formulation and traditional herb tea are organically combined, are convenient to produce and carry, namely rush namely with, old and young suitable, solve the problem that traditional herb tea is in use consuming time, loaded down with trivial details, improve the value of herbal tea greatly.
The invention provides a kind of pestilent cold effervescent tea tablet, comprise following component by weight: tea for common cold extract powder 1 ~ 5 part, filler 1 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part.Wherein said filler is selected from one or more in lactose, water soluble starch or sucrose.Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
Sweeting agent 1-2%, aromatic 0.5-0.8% also can be comprised by mass content in pestilent cold effervescent tea tablet of the present invention.Sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
Present invention also offers a kind of preparation method of pestilent cold effervescent tea tablet, specifically comprise the following steps:
1) preparation of tea for common cold extract powder:
After dry tea for common cold merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
2) following component is taken by recipe quantity: tea for common cold extract powder 1 ~ 5 part, filler 0 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part; Described filler is selected from one or more in lactose, water soluble starch or sucrose.Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate.
3) by disintegrating agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Sweeting agent pulverized 100 ~ 120 mesh sieves, and 140 ~ 200 mesh sieves pulverized by lubricant, and filler pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator; Wherein sweeting agent can be selected from one or more in cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium).
4) Sang Ju Yin extract powder is mixed with sour agent, sweeting agent can be added again or aromatic mix homogeneously obtains powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing.
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required pestilent cold effervescent tea tablet.
Embodiment 1
A kind of pestilent cold effervescent tea tablet, prepares especially by following steps:
After dry tea for common cold is pulverized after merceration 0.5h, add 10 ~ 13 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 80 DEG C, extraction time is 2 times, the solid-liquid ratio of reflux, extract, is 1:13 for the first time, second time reflux, extract, solid-liquid ratio is 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: tea for common cold extract powder 1 part, lactose 5 parts, 4 parts, tartaric acid, sodium bicarbonate 2 parts, polyethylene glycol 6000 0.1 part by recipe quantity; By tartaric acid and sodium bicarbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Polyethylene glycol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in exsiccator; Sang Ju Yin extract powder and tartaric acid are mixed to get powders A; Powder B is obtained by sodium bicarbonate with lactose Homogeneous phase mixing; Add polyethylene glycol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required pestilent cold effervescent tea tablet.
Embodiment 2
A kind of pestilent cold effervescent tea tablet, prepares especially by following steps:
After dry tea for common cold is pulverized after merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 75 DEG C, extraction time is 3 times, the solid-liquid ratio of reflux, extract, is 1:15 for the first time, second time and for the third time reflux, extract, solid-liquid ratio are 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: tea for common cold extract powder 5 parts, water soluble starch 10 parts, citric acid 13 parts, sodium bicarbonate 7 parts, Macrogol 4000 1 part by recipe quantity; By citric acid and sodium bicarbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 4000 pulverized 140 ~ 200 mesh sieves, and water soluble starch pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator; Sang Ju Yin extract powder and citric acid are mixed to get powders A; Powder B is obtained by sodium bicarbonate with water soluble starch Homogeneous phase mixing; Add Macrogol 4000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required pestilent cold effervescent tea tablet.
Embodiment 3
A kind of pestilent cold effervescent tea tablet, prepares especially by following steps:
After dry tea for common cold is pulverized after merceration 0.5h, add 10 ~ 14 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 85 DEG C, extraction time is 3 times, the solid-liquid ratio of reflux, extract, is 1:14 for the first time, second time and for the third time reflux, extract, solid-liquid ratio are 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: tea for common cold extract powder 3 parts, sucrose 5 parts, malic acid 8 parts, sodium carbonate 4 parts, Macrogol 4000 0.2 part by recipe quantity; By malic acid and sodium carbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Macrogol 4000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by sucrose, saved backup in exsiccator; Sang Ju Yin extract powder and malic acid are mixed to get powders A; Powder B is obtained by sodium carbonate with sucrose Homogeneous phase mixing; Add Macrogol 4000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required pestilent cold effervescent tea tablet.
Embodiment 4
A kind of pestilent cold effervescent tea tablet, prepares especially by following steps:
After dry tea for common cold is pulverized after merceration 0.5h, add 10 ~ 12 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 85 DEG C, extraction time is 3 times, the solid-liquid ratio of reflux, extract, is 1:12 for the first time, second time and for the third time reflux, extract, solid-liquid ratio are 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: tea for common cold extract powder 3 parts, sucrose 1 part, 10 parts, tartaric acid, sodium carbonate 5 parts, polyethylene glycol 6000 0.6 part by recipe quantity; By tartaric acid and sodium carbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Polyethylene glycol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by sucrose, saved backup in exsiccator; Sang Ju Yin extract powder and tartaric acid are mixed to get powders A; Powder B is obtained by sodium carbonate with sucrose Homogeneous phase mixing; Add polyethylene glycol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required pestilent cold effervescent tea tablet.
Embodiment 5
A kind of pestilent cold effervescent tea tablet, prepares especially by following steps:
After dry tea for common cold is pulverized after merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 70 DEG C, extraction time is 2 times, the solid-liquid ratio of reflux, extract, is 1:15 for the first time, second time reflux, extract, solid-liquid ratio is 1:10, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
Following component is taken: tea for common cold extract powder 4 parts, lactose 4 parts, anhydrous citric acid 12 parts, sodium carbonate 6 parts, polyethylene glycol 6000 0.3 part by recipe quantity; By anhydrous citric acid and sodium carbonate in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Polyethylene glycol 6000 pulverized 140 ~ 200 mesh sieves, and 100 ~ 120 mesh sieves pulverized by lactose, saved backup in exsiccator; Sang Ju Yin extract powder and anhydrous citric acid are mixed to get powders A; Powder B is obtained by sodium carbonate with lactose Homogeneous phase mixing; Add polyethylene glycol 6000 by after powders A and powder B Homogeneous phase mixing, fully mix, direct compression, obtain required pestilent cold effervescent tea tablet.
Comparative example
Below in conjunction with disintegration, subjective appreciation, hardness, outward appearance evaluate beneficial effect of the present invention:
1, disintegration time detects
In 250mL beaker, add the water of 200mL and water temperature is controlled then add 1 effervescent tablet 15 ~ 25.When gas around tablet or fragment stops overflowing, tablet should be dissolved or dispersed in water, left without the granule assembled.No longer include gas to solution to overflow and the time difference T (s) dissolved is the disintegration time of effervescent tablet, experimental result part table 1 from adding effervescent tablet.
2, subjective appreciation
Scoring: thrown by effervescent tablet in people 300mL water, adopt " double-blind method " to carry out sour-sweet degree organoleptic examination scoring, scoring number is 20 people, averages, full marks 100 points.This accounts for 40% of total score value.Disintegration time is marked, and detects disintegration time by 1, and the shortest for disintegration time in test is decided to be full marks 100 points, and disintegration time often increases 5s and subtracts 1 point.This scoring accounts for total score value 60%, and outward appearance scoring accounts for 20%, mouthfeel 20%, experimental result part table 1.
3, hardness (Monsanto durometer method)
Be placed on by tablet between two pressing plates, diametrically pressurization slowly, the pressure just during fragmentation is the hardness of this effervescent tablet, and unit is N, experimental result part table 1.
4, the test of pesticide effectiveness
The routine patient of clinical observation 60, treatment group 30 example, matched group 30 example.Whole case history all meets case selection standard, man 36 example, female 24 example, age 35-48 year, the course of disease is the shortest 2 days, the longest 2 weeks, takes pestilent cold effervescent tea tablet sheet one week.
Diagnosis basis: disconnected standard is based on the standard of anemopyretic cold card relevant in " disease of tcm Standardization of diagnosis and curative effect ", and 1. heating, micro evil wind are trembled with fear, have a stuffy nose watery nasal discharge, sneeze, headache, general malaise.2. light red tongue or limit point red, platform book is yellow, floating and rapid pulse.3. unusual weather conditions or daily life cause accidentally, sudden onset.
Symptom and sign ranking criterion: according to correlation intergal standard in " traditional Chinese medical science Clinical Researches of New Drugs guideline ", the disappearance of headache, general pain, watery nasal discharge, pharyngalgia, pharyngeal congestion, cough, slight, moderate, severe long-pending 0,1,2,3 point respectively.
Inclusive criteria: meet the diagnostic criteria of traditional Chinese medical science anemopyretic cold card, body temperature is no more than 39 DEG C of persons, and the course of disease is person within 48h, and the age is between 18 ~ 65 years old.
Excluded cases standard: used medicine person as antibiotic, hormone or other cold medicines person or the person that do not bring down a fever; Merge other primary disease persons of pulmonary, as pulmonary tuberculosis, lung swelling and pain person; Merge serious cardiovascular, liver, kidney and disease of hematopoietic system person; Age is under-18s or over-65s person or be trimester of pregnancy, women breast-feeding their children, and body constitution allergy sufferers.
Matched group: conventional tea for common cold.
Criterion of therapeutical effect: cardinal symptom sign curative effect determinate standard more than temperature decline 0.5C is onset, dropping to 37.4C is that temperature recovery is normal.Other symptom and sign integrations reduce by 1 and are divided into onset, and 0 is divided into disappearance.Comprehensive therapeutic effect criterion is fully recovered: within treatment 3d, temperature recovery is normal, and sings and symptoms all disappears, or symptom, somatic feature score decline more than 90% person; Effective: within treatment 3d, body temperature is normal, and most of sings and symptoms disappears, or symptom, somatic feature score decline more than 75% person; Effective: treatment 3d within body temperature reduce than before, cardinal symptom and sign partial disappearance, or symptom, somatic feature score decline more than 50% person; Invalid: within treatment 3d, body temperature does not fall or raises, cardinal symptom and sign are without improvement or improve <50%.Therapeutic outcome: in table 2.
The quality evaluation of table 1 tea for common cold drop pill of the present invention
| Disintegration (s) | Sensory evaluation scores (dividing) | Hardness (N) | |
| Embodiment 1 | 103s | 100 | 62N |
| Embodiment 2 | 146s | 100 | 64N |
| Embodiment 3 | 136s | 93 | 65N |
| Embodiment 4 | 115s | 95 | 67N |
| Embodiment 5 | 107s | 95 | 60N |
| Comparative example | 466s | 52 | 63N |
The observation of curative effect of this effervescent tablet of table 2 treatment anemopyretic cold patient
| Group | Total number of cases | Recovery from illness | Effective | Effectively | Invalid | Total effective rate |
| Embodiment 1 | 30 | 28 | 3 | 0 | 0 | 100％ |
| Embodiment 2 | 30 | 24 | 2 | 1 | 3 | 90％ |
| Embodiment 3 | 30 | 20 | 4 | 3 | 3 | 90％ |
| Embodiment 4 | 30 | 22 | 6 | 1 | 1 | 97％ |
| Embodiment 5 | 30 | 21 | 3 | 2 | 4 | 87％ |
| Comparative example | 30 | 6 | 4 | 5 | 15 | 50％ |
As shown in Table 2, effervescent tablet of the present invention treatment anemopyretic cold effect higher than existing tea for common cold, illustrates effervescent tablet of the present invention very degree remain the medical active of tea for common cold, while more easily played absorption by people, have the advantages that utilization rate is high.
Claims (7)
1. a pestilent cold effervescent tea tablet, is characterized in that, comprises following component by weight: tea for common cold extract powder 1 ~ 5 part, filler 1 ~ 10 part, disintegrating agent 5 ~ 20 parts, lubricant 0.2 ~ 1 part; Described filler is selected from one or more in lactose, water soluble starch or sucrose; Described disintegrating agent is sour agent and alkaline agent weight ratio is the combination of 2:1, described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate; Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
2. a kind of pestilent cold effervescent tea tablet according to claim 1, it is characterized in that, described tea for common cold extract powder is prepared by the following method: after dry tea for common cold merceration 0.5h, add 10 ~ 15 times of water gagings and carry out reflux, extract, reflux, extract, temperature is 55 ~ 95 DEG C, extraction time is 2 ~ 3 times, each 0.5 ~ 2 hour, extracting solution merges, filter, at 80 DEG C, under vacuum 0.07MPa, filtrate is concentrated into the extracting solution of relative density 1.25 ~ 1.35, cool, add 4 ~ 6 times of 50 ~ 80% ethanol, stir standing 24 ~ 72h, leach supernatant, 70 DEG C, under 0.07MPa, decompression recycling ethanol is extremely without alcohol taste, continue at 80 DEG C, be concentrated into the stiff paste that relative density is 1.20 ~ 1.30, dry with spray dryer, pulverized 40 ~ 100 mesh sieves, obtain extract powder.
3. a kind of pestilent cold effervescent tea tablet according to claim 1, is characterized in that, also can comprise sweeting agent 1-2%, aromatic 0.5-0.8% in pestilent cold effervescent tea tablet of the present invention by mass content; Sweeting agent be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium (calcium) one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
4. a preparation method for pestilent cold effervescent tea tablet, is characterized in that, comprises the following steps:
1) preparation of tea for common cold extract powder;
2) following component is taken by recipe quantity: tea for common cold extract powder 1 ~ 5 part, filler 1 ~ 10 part, sour agent and 5 ~ 20 parts, alkaline agent mixture, lubricant 0.2 ~ 1 part;
3) by sour agent and alkaline agent in 90 ~ 10 DEG C of dryings 1 ~ 2 hour, pulverized 100 ~ 120 mesh sieves, airtightly to save backup; Sweeting agent pulverized 100 ~ 120 mesh sieves, and 140 ~ 200 mesh sieves pulverized by lubricant, and filler pulverized 100 ~ 120 mesh sieves, saved backup in exsiccator;
4) Sang Ju Yin extract powder is mixed with sour agent, then add sweeting agent or aromatic mix homogeneously obtains powders A; Powder B is obtained by alkaline agent with filler Homogeneous phase mixing;
5) add lubricant by after powders A and powder B Homogeneous phase mixing, fully mix;
6) by gained mixed-powder direct compression, required pestilent cold effervescent tea tablet is obtained.
5. preparation method according to claim 4, is characterized in that,
Described filler is selected from one or more in lactose, water soluble starch or sucrose;
Described sour agent and alkaline agent weight ratio are 2:1, and described sour agent is selected from one or more in tartaric acid, malic acid, anhydrous citric acid, citric acid or sodium dihydrogen citrate salt, and described alkaline agent is selected from one or more in sodium carbonate or sodium bicarbonate;
Described lubricant is selected from polyethylene glycol 6000 or Macrogol 4000.
6. preparation method according to claim 4, is characterized in that, described tea for common cold extract powder is prepared by method described in claim 2.
7. preparation method according to claim 4, it is characterized in that, described sweeting agent and aromatic account for 1-2% and 0.5-0.8% of raw material total amount, sweeting agent can be selected from cyclamate, steviosin, acesulfame potassium, aspartame, protein sugar, sucrose, protein sugar, saccharin sodium one or more, aromatic be selected from orange essence, flavoring orange essence, Mint Essence or Fructus Citri Limoniae essence, flavoring banana essence one or more.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425413A (en) * | 2002-12-27 | 2003-06-25 | 中山大学 | Xiasangju effervescent tablet and its preparing process |
| CN102771612A (en) * | 2012-08-22 | 2012-11-14 | 李娴 | Four Seasons Cold Tea |
| CN104705763A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Sangju effervescent tablet |
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2015
- 2015-12-08 CN CN201510901683.2A patent/CN105456224A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1425413A (en) * | 2002-12-27 | 2003-06-25 | 中山大学 | Xiasangju effervescent tablet and its preparing process |
| CN102771612A (en) * | 2012-08-22 | 2012-11-14 | 李娴 | Four Seasons Cold Tea |
| CN104705763A (en) * | 2015-03-07 | 2015-06-17 | 湖北卫尔康现代中药有限公司 | Sangju effervescent tablet |
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Application publication date: 20160406 |