CN105445083B - Exempt to centrifuge whole blood processing module - Google Patents
Exempt to centrifuge whole blood processing module Download PDFInfo
- Publication number
- CN105445083B CN105445083B CN201510966838.0A CN201510966838A CN105445083B CN 105445083 B CN105445083 B CN 105445083B CN 201510966838 A CN201510966838 A CN 201510966838A CN 105445083 B CN105445083 B CN 105445083B
- Authority
- CN
- China
- Prior art keywords
- filter membrane
- upper layer
- outer ring
- layer filter
- whole blood
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N1/00—Sampling; Preparing specimens for investigation
- G01N1/28—Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
- G01N1/34—Purifying; Cleaning
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Abstract
The present invention provides one kind to exempt to centrifuge whole blood processing module, include from top to bottom upper layer filter membrane, adsorption layer and lower layer's filter membrane successively, the upper layer filter membrane is made of glass fiber filter paper or microporous barrier, the upper layer filter membrane is formed by stacking by multilayer filter membrane, the upper layer filter sizes gradually decrease from top to bottom, the adsorption layer for no swelling action hydrophobic material, lower layer's filter membrane is made of glass fiber filter paper or microporous barrier, the aperture of lower layer's filter membrane is less than the aperture of the upper layer filter membrane, and the outside of the adsorption layer is equipped with outer ring.Manual pressure of the present invention provides power for filtering by syringe pressure, has not both needed the processing step of high-cost centrifugation apparatus and complexity, can also reduce the consumption of sample.
Description
Technical field
The invention belongs to whole blood process field, exempt to centrifuge whole blood processing module more particularly, to one kind.
Background technology
In recent years, it is widely used in clinical with a large amount of abuses and immunosuppressor of antibiotic, aggressive deep is true
The incidence and case fatality rate of bacterium infection are higher and higher.Wherein, aspergillus, cryptococcus and candida albicans have been increasingly becoming clinically several
The important pathomycete of kind.Aspergillus, cryptococcus and the Exoantigen of candida albicans are respectively galactomannans antigen, pod
Film polysaccharide antigen and mannan antigen can be found in infection early stage from blood samples of patients.Therefore it is detected based on immune response
Antigen is a kind of widest method of purposes in current fungal infection detection, but this method has the removal of impurities and purifying of blood sample
Higher requirement.
Vitro detection based on immune response needs to carry out pre-processing to blood or body fluid, removes unnecessary interference
Substance just can make immune response more accurately and fast.Traditional whole blood processing, needs the blood sample that will be obtained to pass through anti-freezing
After blood agent processing, centrifugal treating is carried out, other ingredients (blood platelet, the blood in haemocyte (red blood cell, leucocyte) and blood are made
Starch albumin, globulin etc.) precipitation, and obtain supernatant (blood plasma).When detecting polysaccharide antigen using immune response, on blood
Clear liquid also needs to be further processed, and treatment fluid, such as EDTA is added, and the means such as heated centrifugation remove the major part in blood plasma
Protein.The above blood treatment means need, using equipment such as centrifuges, to be unfavorable for integrating with micro-fluidic chip, considerably increase
The time of detection and the consumption of sample.Since sample needed for micro-fluidic chip is less, the side such as physical filtering and absorption can be passed through
Method carries out the processing of blood, obtains the required sample for filtering out protein.
The common method of physical absorption protein has：Molecular sieve, ion exchange, drainage column and affinity chromatography etc..It can be with
According to the difference of molecular weight of albumen size, the difference of the charging property of albumen, or the specific binding with aglucon reach protein
Separation and absorption.It since the design main purpose is to filter out protein, does not need to specificity and filters out, therefore using thin
The method of water material indifference opposite sex absorption.
Invention content
In view of this, the present invention is directed to propose one kind is exempted to centrifuge whole blood processing module, whole blood sample is without carrying out at centrifugation
Reason, reduces the time of detection, reduces the consumption of sample.
In order to achieve the above objectives, the technical proposal of the invention is realized in this way：
One kind is exempted to centrifuge whole blood processing module, described from top to bottom successively including upper layer filter membrane, adsorption layer and lower layer's filter membrane
Upper layer filter membrane is made of glass fiber filter paper or microporous barrier, and the upper layer filter membrane is formed by stacking by multilayer filter membrane, the upper layer filter
Membrane aperture gradually decreasees from top to bottom, and the present invention filters adsorption structure using filter membrane sandwich, and the main purpose of upper layer filter membrane is
Haemocyte is filtered out, the adsorption layer is the hydrophobic material of no swelling action, and lower layer's filter membrane is by glass fiber filter paper or micropore
Film forms, and the aperture of lower layer's filter membrane is less than the aperture of the upper layer filter membrane, it is preferred that the upper layer filter membrane and the lower layer
Filter membrane is circle, and the outside of the adsorption layer is equipped with outer ring.
Further, the adsorption layer is C18 dewatering fillings, and the aperture of the adsorption layer is less than the hole of the upper layer filter membrane
Diameter, middle layer are hydrophobic adsorbent layer, and filler is the dewatering filling of the unsoluble-unexpansives matter such as C18, carries out protein without selection
Absorption, loading can prepare different size according to the substance of different detections to protein abundance requirement in serum after processing.Due in
Between filler be in dry environment using preceding, a large amount of wastes of sample can be caused by being directly used in filtering, while may make suction
Attached efficiency reduces, therefore preferably uses buffer solution or distilled water to soak before the use.
Further, the outer ring is hollow cylinder, the outer diameter of the outer ring be greater than or equal to the upper layer filter membrane and
The diameter of lower layer's filter membrane, the internal diameter of the outer ring are less than the diameter of the upper layer filter membrane and lower layer's filter membrane, set in this way
The purpose set is that the edge of the upper layer filter membrane and lower layer's filter membrane can be fallen on the outer ring, and the outer ring can rise
To the effect of the fixation upper layer filter membrane, lower layer's filter membrane and the adsorption layer.
Further, the upper layer filter membrane and the outer ring bonding connection, lower layer's filter membrane is Nian Jie with the outer ring to be connected
It connects, the periphery of the upper layer filter membrane is Nian Jie with the upper surface of the outer ring, under the periphery and the outer ring of lower layer's filter membrane
The middle section of end face bonding connection, the upper layer filter membrane and lower layer's filter membrane can be used normally.
Further, the number of plies of the upper layer filter membrane is 3-5 layers, the aperture of the upper layer filter membrane 0.2 μm -10 μm it
Between, to ensure to filter out high efficiency and high flow rate, stacked using the filter membrane gradient of decreasing pore size, in case excessive haemocyte is simultaneously
Filtering, it is blocking microporous, cause cutout phenomenon.
Further, it is combined with each other in such a way that periphery is bonded between the upper layer filter membrane, when bonding, by the upper layer
The periphery of filter membrane is bonded, and the middle section of the upper layer filter membrane can normal use.
Further, the main function of lower layer's filter membrane is as carrying, and the aperture of preferred lower layer's filter membrane is omited
Less than middle layer filler diameter, glass fiber material preferably is used to reduce the unnecessary waste of sample, lower layer's filter membrane
Lower section be equipped with arc collection portion, the arc collection portion includes circumferentially disposed taper cambered surface and below the cambered surface
Collection port, the cambered surface raise up, and the cambered surface can efficiently collect liquid, and instill desired zone, the collection
Mouth is located at the centre of the arc collection portion, and the size of the collection port is matched with the exit size of commercially available syringe.
Further, the top of the upper layer filter membrane is equipped with threaded portion, and the maximum outside diameter of the threaded portion is equal to outside described
The centre of the outer diameter of circle, the threaded portion is hollow-core construction, and the upper layer filter membrane is now placed in the inside of the threaded portion, preferably
, the diameter of the upper layer filter membrane is equal to the internal diameter of the threaded portion, at this point, nothing between the upper layer filter membrane and the threaded portion
Gap avoids under blood lateral flow, and the threaded portion is arranged, on the one hand, can increase the frictional force with syringe inner chamber body, separately
On the one hand, internal thread is equipped in presently commercially available syringe cavity body, it is preferred that by the external screw thread of the threaded portion and commercially available injection
The screw-internal thread fit of device can obtain better bonding strength, is fixedly connected above the threaded portion and the outer ring, connection
Mode is welding or bonding, can also be integrally formed.
In use, it should be noted that the internal diameter specification of commercially available syringe cavity is different, needle is for the purpose of the present invention, described
The outer diameter of outer ring is equal with the internal diameter of mating syringe, and the present invention is placed in commercially available syringe, syringe outlet is screwed in
One end, by pending blood injection syringe cavity body, injection mode can be, but not limited to be instilled using dropper or use it
Then he pushes blood sample, blood sample is by the upper layer filter membrane, adsorption layer at syringe injection using syringe piston
With after lower layer filter membrane, flows out from the outlet of syringe, be detected into micro-fluidic sample inlet area.
Compared with the existing technology, the present invention has the advantage that：Manual pressure, by syringe pressure for filtering provide it is dynamic
Power had not both needed the processing step of high-cost centrifugation apparatus and complexity, and can also reduce the consumption of sample.
Description of the drawings
The attached drawing for constituting the part of the present invention is used to provide further understanding of the present invention, schematic reality of the invention
Example and its explanation are applied for explaining the present invention, is not constituted improper limitations of the present invention.In the accompanying drawings：
Fig. 1 is 1 main view direction structure schematic diagram of the embodiment of the present invention；
Fig. 2 is 2 main view direction structure schematic diagram of the embodiment of the present invention；
Fig. 3 is 3 stereo directional decomposition texture schematic diagram of the embodiment of the present invention；
Fig. 4-5 is 3 main view direction structure schematic diagram of the embodiment of the present invention.
Reference sign：
The upper layers 1- filter membrane；2- adsorption layers；3- lower layers filter membrane；The outer rings 4-；5- arc collection portions；51- cambered surfaces；52- collection ports；
The threaded portions 6-.
Specific implementation mode
It should be noted that in the absence of conflict, the feature in embodiment and embodiment in the present invention can phase
Mutually combination.
In the description of the present invention, it is to be understood that, term "center", " longitudinal direction ", " transverse direction ", "upper", "lower",
The orientation or positional relationship of the instructions such as "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outside" is
It is based on the orientation or positional relationship shown in the drawings, is merely for convenience of description of the present invention and simplification of the description, rather than instruction or dark
Show that signified device or element must have a particular orientation, with specific azimuth configuration and operation, therefore should not be understood as pair
The limitation of the present invention.In addition, term " first ", " second " etc. are used for description purposes only, it is not understood to indicate or imply phase
To importance or implicitly indicate the quantity of indicated technical characteristic.The feature for defining " first ", " second " etc. as a result, can
To express or implicitly include one or more this feature.In the description of the present invention, unless otherwise indicated, " multiple "
It is meant that two or more.
In the description of the present invention, it should be noted that unless otherwise clearly defined and limited, term " installation ", " phase
Even ", " connection " shall be understood in a broad sense, for example, it may be being fixedly connected, may be a detachable connection, or be integrally connected；It can
Can also be electrical connection to be mechanical connection；It can be directly connected, can also indirectly connected through an intermediary, Ke Yishi
Connection inside two elements.For the ordinary skill in the art, above-mentioned term can be understood by concrete condition
Concrete meaning in the present invention.
The present invention will be described in detail below with reference to the accompanying drawings and embodiments.
Embodiment 1
Exempt to centrifuge whole blood processing module, it is described from top to bottom successively including upper layer filter membrane 1, adsorption layer 2 and lower layer's filter membrane 3
Upper layer filter membrane 1 is made of glass fiber filter paper or microporous barrier, and the number of plies of the upper layer filter membrane 1 is 3-5 layers, the upper layer filter membrane 1
Between be combined with each other in such a way that periphery is bonded, the aperture of the upper layer filter membrane 1 is between 0.2 μm -10 μm, upper layer filter
1 aperture of film gradually decreasees from top to bottom, and the adsorption layer 2 is C18 dewatering fillings, and the aperture of the adsorption layer 2 is less than on described
The aperture of layer filter membrane 1, lower layer's filter membrane 3 are made of glass fiber filter paper or microporous barrier, and the aperture of lower layer's filter membrane 3 is less than
The aperture of the upper layer filter membrane 1, the upper layer filter membrane 1 and lower layer's filter membrane 3 are circle, and the outside of the adsorption layer 2 is set
Have an outer ring 4, the outer ring 4 is hollow cylinder, the outer diameter of the outer ring 4 be greater than or equal to the upper layer filter membrane 1 and it is described under
The diameter of layer filter membrane 3, the internal diameter of the outer ring 4 are less than the diameter of the upper layer filter membrane 1 and lower layer's filter membrane 3, the upper layer
Filter membrane 1 and 4 bonding connection of the outer ring, lower layer's filter membrane 3 and 4 bonding connection of the outer ring.
Embodiment 2
Embodiment 2 and the structure of embodiment 1 are essentially identical, embodiment 2 difference from example 1 is that:Under described
The lower section of layer filter membrane 3 is equipped with arc collection portion 5, and the arc collection portion 5 is including circumferentially disposed taper cambered surface 51 and is located at institute
The collection port 52 of 51 lower section of cambered surface is stated, the cambered surface 51 raises up.
Embodiment 3
Embodiment 3 and the structure of embodiment 1 are essentially identical, embodiment 2 difference from example 1 is that:On described
The top of layer filter membrane 1 is equipped with threaded portion 6, and the maximum outside diameter of the threaded portion 6 is equal to the outer diameter of the outer ring 4, the threaded portion 6
Centre be hollow-core construction.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
With within principle, any modification, equivalent replacement, improvement and so on should all be included in the protection scope of the present invention god.
Claims (6)
1. exempting to centrifuge whole blood processing module, it is characterised in that：Include from top to bottom upper layer filter membrane, adsorption layer and lower layer's filter successively
Film, the upper layer filter membrane are made of glass fiber filter paper or microporous barrier, and the upper layer filter membrane is formed by stacking by multilayer filter membrane, described
Upper layer filter sizes gradually decrease from top to bottom, the adsorption layer for no swelling action hydrophobic material, lower layer's filter membrane by
Glass fiber filter paper or microporous barrier composition, the aperture of lower layer's filter membrane are less than the aperture of the upper layer filter membrane, the adsorption layer
Outside be equipped with outer ring, be combined with each other in such a way that periphery is bonded between the upper layer filter membrane；
The adsorption layer is C18 dewatering fillings, and the aperture of the adsorption layer is less than the aperture of the upper layer filter membrane；
The number of plies of the upper layer filter membrane is 3-5 layers, and the aperture of the upper layer filter membrane is between 0.2 μm -10 μm.
2. according to claim 1 exempt to centrifuge whole blood processing module, it is characterised in that：The upper layer filter membrane and the lower layer
Filter membrane is circle.
3. according to claim 1 exempt to centrifuge whole blood processing module, it is characterised in that：The outer ring is hollow cylinder,
The outer diameter of the outer ring is greater than or equal to the diameter of the upper layer filter membrane and lower layer's filter membrane, and the internal diameter of the outer ring is less than institute
State the diameter of upper layer filter membrane and lower layer's filter membrane.
4. according to claim 1 exempt to centrifuge whole blood processing module, it is characterised in that：The upper layer filter membrane and the outer ring
Bonding connection, lower layer's filter membrane and the outer ring bonding connection.
5. according to claim 1 exempt to centrifuge whole blood processing module, it is characterised in that：The lower section of lower layer's filter membrane is equipped with
Arc collection portion, the arc collection portion include circumferentially disposed taper cambered surface and the collection port below the cambered surface, institute
Cambered surface is stated to raise up.
6. according to claim 1 exempt to centrifuge whole blood processing module, it is characterised in that：The top of the upper layer filter membrane is equipped with
Threaded portion, the maximum outside diameter of the threaded portion are equal to the outer diameter of the outer ring, and the centre of the threaded portion is hollow-core construction.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510966838.0A CN105445083B (en) | 2015-12-21 | 2015-12-21 | Exempt to centrifuge whole blood processing module |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510966838.0A CN105445083B (en) | 2015-12-21 | 2015-12-21 | Exempt to centrifuge whole blood processing module |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105445083A CN105445083A (en) | 2016-03-30 |
| CN105445083B true CN105445083B (en) | 2018-09-11 |
Family
ID=55555542
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510966838.0A Active CN105445083B (en) | 2015-12-21 | 2015-12-21 | Exempt to centrifuge whole blood processing module |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105445083B (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107638810A (en) * | 2016-07-20 | 2018-01-30 | 中国石油天然气股份有限公司 | Filter membrane assembly and filter device with same |
| CN106840828B (en) * | 2017-03-29 | 2020-02-14 | 天津中新科炬生物制药股份有限公司 | Method and device for quickly separating plasma from trace whole blood |
| CN108362543A (en) * | 2018-02-08 | 2018-08-03 | 上海蓝怡科技股份有限公司 | A kind of serum separator and the method using its progress serum separation |
| CN109925884A (en) | 2019-04-27 | 2019-06-25 | 南京岚煜生物科技有限公司 | A kind of method of Whole Blood Filtration and filter membrane structure for Whole Blood Filtration |
| CN115407078B (en) * | 2022-11-01 | 2023-01-31 | 丹娜(天津)生物科技股份有限公司 | Analyzer with sample preprocessing function and sample preprocessing method |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1142346A (en) * | 1995-08-09 | 1997-02-12 | 中国科学院大连化学物理研究所 | Blood plasma separator for clinic laboratory analysis on blood constituents |
| CN1248171A (en) * | 1996-11-08 | 2000-03-22 | 帕尔公司 | Method for purifying blood plasma and apparatus suitable therefor |
| CN1684727A (en) * | 2002-09-12 | 2005-10-19 | 旭化成医疗有限公司 | Plasma purifying membrane and plasma purifying system |
| CN1714292A (en) * | 2002-11-19 | 2005-12-28 | 积水化学工业株式会社 | Plasma or serum separation membrane and filter including plasma or serum separation membrane |
| CN104519976A (en) * | 2012-08-09 | 2015-04-15 | 霍夫曼-拉罗奇有限公司 | Multi-part device for extracting plasma from blood |
| CN104548232A (en) * | 2013-10-15 | 2015-04-29 | 金鸿 | Device and method of extracting high-concentration plasma from whole blood |
| CN205301048U (en) * | 2015-12-21 | 2016-06-08 | 丹娜（天津）生物科技有限公司 | Centrifugal whole blood processing module exempts from |
-
2015
- 2015-12-21 CN CN201510966838.0A patent/CN105445083B/en active Active
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1142346A (en) * | 1995-08-09 | 1997-02-12 | 中国科学院大连化学物理研究所 | Blood plasma separator for clinic laboratory analysis on blood constituents |
| CN1248171A (en) * | 1996-11-08 | 2000-03-22 | 帕尔公司 | Method for purifying blood plasma and apparatus suitable therefor |
| CN1684727A (en) * | 2002-09-12 | 2005-10-19 | 旭化成医疗有限公司 | Plasma purifying membrane and plasma purifying system |
| CN1714292A (en) * | 2002-11-19 | 2005-12-28 | 积水化学工业株式会社 | Plasma or serum separation membrane and filter including plasma or serum separation membrane |
| CN104519976A (en) * | 2012-08-09 | 2015-04-15 | 霍夫曼-拉罗奇有限公司 | Multi-part device for extracting plasma from blood |
| CN104548232A (en) * | 2013-10-15 | 2015-04-29 | 金鸿 | Device and method of extracting high-concentration plasma from whole blood |
| CN205301048U (en) * | 2015-12-21 | 2016-06-08 | 丹娜（天津）生物科技有限公司 | Centrifugal whole blood processing module exempts from |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105445083A (en) | 2016-03-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN105445083B (en) | Exempt to centrifuge whole blood processing module | |
| EP3808434B1 (en) | Whole blood filtering method and filter membrane structure for whole blood filtering | |
| US9907899B2 (en) | Device and method of extracting high-concentration plasma from whole blood | |
| Tay et al. | Direct isolation of circulating extracellular vesicles from blood for vascular risk profiling in type 2 diabetes mellitus | |
| US20170173246A1 (en) | Extracorporeal Fluidic Device for Collecting Circulating Tumor Cells and Method of Use Thereof | |
| EP2238079A2 (en) | Method and apparatus for increasing contaminant clearance rates during extracorporeal fluid treatment | |
| CN108042866A (en) | For treating the plasma filtering device of acute cerebral infarction and method | |
| US20190201848A1 (en) | Device for blood collection | |
| CN203989201U (en) | A kind of based on Diapact CRRT machine and for the improved device of Cured by Double Filtration Plasmapheresis plasmapheresis | |
| CN104020012A (en) | Sampling filtering bag for cryptospsridium and giardia detection in water | |
| RU2721435C2 (en) | Outlet element with filter | |
| WO2012018762A8 (en) | Systems, devices and methods for high volume fluid filtering | |
| CN106085832A (en) | A kind of circulating tumor cell automatic separation system | |
| CN105112289A (en) | Cell separation device and dispenser applied to same | |
| CN205301048U (en) | Centrifugal whole blood processing module exempts from | |
| CN209968132U (en) | Filter membrane structure for whole blood filtration | |
| CN218475122U (en) | Blood filtering device | |
| CN106659834A (en) | System for removing pro-inflammatory mediators as well as granulocytes and monocytes from blood | |
| CN211584545U (en) | A blood purification device with membrane separation and perfusion coupling | |
| WO2006020100A3 (en) | Continuous blood separator | |
| CN106512121A (en) | Method and filtering device for removing AIDS viruses | |
| CN108175888B (en) | Blood toxin adsorber | |
| WO2019104637A1 (en) | Method, system and filtration unit for the isolation of particles from biological samples | |
| CN219596297U (en) | Deep filtration system and antibody medicine purification device | |
| JP4188047B2 (en) | Leukocyte-containing liquid filtration method and apparatus |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| CP03 | Change of name, title or address |
Address after: 300467, 101, building 1, building 14, ecological science and Technology Park, eco Road, 2018, Tian Cheng Avenue, ecological town, Tianjin Binhai New Area,. -2 Patentee after: Dana (Tianjin) Biotechnology Co.,Ltd. Address before: 300467 Building 1, building 14, eco science and Technology Park, 2018 eco Road, eco city, Binhai New Area, Tianjin Patentee before: DYNAMIKER BIOTECHNOLOGY (TIANJIN) Co.,Ltd. |
|
| CP03 | Change of name, title or address | ||
| CP02 | Change in the address of a patent holder |
Address after: 300467 Building 2, Rongzhi Industrial Park, 3667 Zhongbin Avenue, Zhongxin ecological city, Binhai New Area, Tianjin Patentee after: Dana (Tianjin) Biotechnology Co.,Ltd. Address before: Room 101-2, 1/F, 14 (3B) 1/F, Office Building, Eco-Tech Park, No. 2018 Zhongtian Avenue, Binhai New Area, Tianjin Patentee before: Dana (Tianjin) Biotechnology Co.,Ltd. |
|
| CP02 | Change in the address of a patent holder |