CN105418858A - Silicon hydrogel material having high oxygen permeability, corneal contact lens, and preparation method thereof - Google Patents

Abstract

The invention discloses a silicon hydrogel material with high oxygen permeability. The silicon hydrogel material is formed by polymerization reaction of the following components according to the mass fraction: amphiphilic macromolecular silicon monomer: 10-40 Parts, small molecular silicon monomer: 10-30 parts, hydrophilic monomer: 40-80 parts, organic solvent: 0-30 parts, initiator and crosslinking agent. The silicone hydrogel material and the corneal contact lens have high oxygen permeability, low cost and simple preparation.

Description

Silicone hydrogel material with high oxygen permeability, corneal contact lens and preparation method thereof

technical field

The invention relates to a silicon hydrogel material, in particular to a silicon hydrogel material with high oxygen permeability, a corneal contact lens and a preparation method thereof.

Background technique

Since the 1950s, contact lenses have gradually appeared in the market to correct vision, protect the eyeball or increase the beauty of the eye. With the development of science and technology, contact lenses have also realized the development from hard materials to soft materials that are more suitable for human eyes.

The earliest lens material appeared was the rigid contact lens. Due to its shortcomings such as hard material, poor wettability, and low oxygen permeability, it is easy to cause eye discomfort when worn, and it is no longer the main commercially available lens. Subsequently, soft contact lenses were gradually developed, which can be divided into hydrophilic materials and non-hydrophilic materials. Hydrophilic contact lenses are mainly formed by copolymerization of hydrophilic monomers such as hydroxyethyl methacrylate (HEMA). Polymer with hydroxypropyl ester as the hydrophilic part and 2-methoxyethyl methacrylate as the hydrophobic part. The advantage of this type of material is that it is highly hydrophilic, and can increase the oxygen carrying capacity by increasing the water content. It is comfortable to wear in a short period of time, but the contact lens coverage greatly reduces the contact between the eyeball and oxygen in the air, and with the wearing As time goes on, the water in the high-water lens will gradually volatilize, and the oxygen carrying capacity will be greatly affected. At the same time, the lens cannot penetrate the oxygen required by the normal physiological metabolism of the human cornea for a long time, which will easily cause ophthalmic diseases. The main material for non-hydrophilic cloaking is fluorosilicone polymer. The flexibility and loose structure of the long chain of siloxane can directly transmit oxygen in the air to the eyeball, making this type of material more than 8 times more oxygen permeable than traditional hydrophilic materials, breaking the traditional hydrophilic material relying on water Oxygen-carrying limitations, but this type of material is highly hydrophobic, easily absorbs the protein in tears, and has a hard texture and poor comfort.

Due to the shortage of the above materials, scientists are committed to finding more optimal lens materials. Silicone hydrogel combines the advantages of high oxygen permeability of silicone rubber material and strong hydrophilicity of hydrogel material, and is currently the most potential soft contact lens material. The long chains of siloxane form the continuous phase of the "honeycomb" structure, providing a good channel for oxygen transmission, and the hydrophilic part becomes a hydrogel after swelling, providing good comfort for the wearer. This material can meet the requirements of continuous wear, and some silicone hydrogel contact lenses can be worn continuously for several weeks or even a month, gradually replacing traditional pure water-swellable gel lenses, and is expected to gain a larger market.

However, there are still many problems with silicon hydrogel materials. The hydrophobicity of the silicon-containing material is easy to absorb proteins such as lysozyme in tears, and it is easy to adhere to the eyeball and affect the free rotation of the contact lens. To solve this problem, directly modifying the surface of the material has become an important direction to improve the performance of the lens. Oxygen plasma treatment technology is widely used, and its main principle is to embed some highly hydrophilic groups, such as -OH, -COOH, on the surface of polydimethylsiloxane (PDMS) through the active center. The Chinese patent with the publication number CN104204099A introduces a low-temperature plasma coating for anti-biofilm formation, which uses a liquid contact device to form a biofilm that inhibits bacterial adhesion through plasma deposition technology at low temperature. However, this treatment method increases the pipeline production process, and the surface hydrophilicity cannot be permanently maintained due to chain migration.

In addition, surface grafting is also an important and practical surface modification. The Chinese patent with publication number CN1583834A discloses a silicone rubber with permanent hydrophilic surface. The main method is to react silicon-hydrogen bonds with diol monomers such as allyl polyethylene glycol to generate Si-C covalent bonds, thereby modifying On the surface of silicone rubber, polyethylene glycol with macromolecular chains can form a dense layer on the surface of PDMS, which not only maintains a high degree of hydrophilicity, but also effectively reduces protein adsorption. However, such processes are relatively complicated and require secondary production. First, a preformed SiHy contact lens is formed, and then the hydrophilic monomer is cross-linked for the second time.

In recent years, scientists have devoted themselves to improving the hydrophilic properties of the material body. The main method is to copolymerize polydimethylsiloxane containing methacrylate and strong hydrophilic biocompatible group monomers. , forming a network structure in which the silicone rubber phase and the hydrogel phase interpenetrate each other, but there are also many problems.

First of all, methacrylic acid-terminated siloxane macromolecular chains with a molecular weight of several thousand or even tens of thousands have strong hydrophobicity, and can be mixed with various methacrylate or vinyl hydrophilic monomers to obtain good compatibility. It is not easy to prepare a lens with a light transmittance above 97%, and the phase separation caused by the incompatibility between the hydrophilic monomer and the hydrophobic monomer is a difficult problem in the production of this type of lens. ShuaPeng et al. (SOFTMATTER, 2012, 40: 10493-10501) have listed the phase diagram of water, methacrylic acid-terminated polydimethylsiloxane, and nonionic surfactant (TericG9A8) through research. The results It shows that only when the oil phase and water phase reach an appropriate ratio, can the single-phase region of water-in-oil or oil-in-water be formed, otherwise the turbidity and phase separation can be formed. In response to this problem, scientists had to develop amphiphilic compatibilizing monomers to improve the compatibility of the mixed solution, thereby improving the light transmittance of the lens. Usually the development of amphiphilic compatibilizing monomers is difficult and expensive. Appropriate organic solvents are also added to the formula as a simple compatibilizing agent. An appropriate amount of solvent can indeed improve the compatibility of the lens, but the addition of the solvent also destroys the original network structure and reduces the quality of the finished lens. Strength and toughness.

In addition to the above copolymerization methods, the formation of an interpenetrating network structure by macromolecular silicone monomers and macromolecular hydrophilic monomers is also a commonly used method. The macromolecular hydrophilic monomers used to form the network structure include polyvinylpyrrolidone, polyvinyl alcohol, and polymethacrylate-β-hydroxyethyl ester with a molecular weight of tens of thousands to hundreds of thousands. Relying on the intertwining of long molecular chains to form a network structure, after soaking in water or saline for a period of time, the hydrogel phase will slowly dissolve, which cannot guarantee long-lasting hydrophilicity, let alone the stability of drug release .

Secondly, the prepolymer synthesis of some silicone hydrogels is quite cumbersome and the manufacturing process is complicated. For example JohnChristopherPhelan (US20100120938A1) et al. have developed a silicon-containing hydrogel, the macromolecules are amphiphilic monomers with siloxane long chains, and contain hydrophilic monomers such as methyl methacrylate to provide better Water content, containing N-vinylpyrrolidone provides better biocompatibility. However, the synthesis of monomers is relatively complicated, requiring step-by-step catalytic synthesis of catalysts and ultraviolet light, and is not suitable for large-scale industrial production.

Therefore, contact lenses still have high oxygen permeability, strong hydrophilicity, low elastic modulus, high transparency, high biocompatibility, simple process, and easy mass production.

Contents of the invention

Technical problem: The technical problem to be solved by the embodiments of the present invention is to provide a silicon hydrogel material, a contact lens and a preparation method thereof, the silicon hydrogel material and the contact lens have high oxygen permeability and are low in cost , the preparation is simple.

Technical problem: In order to solve the above-mentioned technical problem, the technical scheme that the embodiment of the present invention adopts is:

In the first aspect, this embodiment provides a silicon hydrogel material with high oxygen permeability, which is formed by polymerization reaction of the following components in parts by mass:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

In combination with the first aspect, as the first possible implementation scheme, the amphiphilic macromolecular silicon monomer has the molecular formula of the following structure:

or

Wherein, the structural formula of X is as follows:

Wherein, the value range of a is an integer ranging from 1 to 14, the value range of b is an integer ranging from 1 to 6, and the value range of c is an integer ranging from 13 to 68.

In combination with the first aspect, as a second possible implementation scheme, the small molecular silicon monomer comprises methacryloxypropyltris(trimethylsiloxane)silane, methyl-bis(trimethylsiloxane) Siloxane) - silylpropyl glyceryl methacrylate (SIGMA), 3-(methacryloxy)propyltrimethoxysilane, methacryloxymethyltris(trimethylsiloxane) One or any combination of silanes.

In combination with the first aspect, as a third possible solution, the hydrophilic monomer is N-vinylpyrrolidone (NVP), methacrylic acid (MMA), hydroxyethyl methacrylate (HEMA), N - A combination of any two or more of vinyl-N-methylacetamide (VMA) and N-vinylacetamide (NVA).

In conjunction with the first aspect, as a fourth possible implementation scheme, the described initiator is a photoinitiator or a thermal initiator; the described photoinitiator is 2-hydroxyl-2-methylpropiophenone (D1173), and the thermal initiator is The initiator is one or a combination of azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO).

In combination with the first aspect, as a fifth possible implementation, the crosslinking agent is polyethylene glycol diacrylate (PEGDA), ethylene glycol dimethacrylate (EGDMA) or triene isocyanurate One or any combination of propyl esters (TAIC).

In combination with the first aspect, as a sixth possible implementation solution, the organic solvent is one or any combination of isopropanol, ethanol, n-hexanol, n-butanol.

In the second aspect, the present embodiment provides a contact lens, which is made of a silicon hydrogel material, and the silicon hydrogel material is formed by polymerization reaction of the following components in parts by mass:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

In combination with the second aspect, as a seventh possible solution, the silicon hydrogel material is polymerized by the following components in parts by mass:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 2% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.5-3%.

In the third aspect, this embodiment provides a method for preparing a contact lens. The preparation method includes the following steps: mixing the components uniformly, injecting them into a contact lens mold, photo-induced or heat-induced polymerization, and then demoulding, removing Ionized water extraction removes unpolymerized monomers and oligomers in the lens, immerses in physiological saline to balance, and makes a contact lens; wherein, each component includes the following components in parts by mass:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

Beneficial effects: Compared with the prior art, the technical solution of the embodiment of the present invention has the following beneficial effects: the contact lens of the embodiment of the present invention has an oxygen permeability that is more than 8 times higher than that of the traditional soft contact lens, and belongs to the high oxygen permeability type The contact lens also has excellent light transmission performance, good elongation and good water content, and meets the wearing standard. In the production process, the process is simple, no secondary production is required, and compared with the high oxygen permeability and good hydrophilicity lenses currently on the market, it is more cost-effective and labor-saving. The corneal contact lens made of the above silicone hydrogel has good oxygen permeability and hydrophilicity, and the lens can be worn without surface treatment.

detailed description

The technical solution of the present invention will be described in detail below in conjunction with the embodiments.

Example 1

A silicone hydrogel material with high oxygen permeability provided in this embodiment is formed by polymerization reaction of the following components in parts by mass:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

In above-mentioned embodiment 1, macromolecular silicon monomer has the molecular formula of following structure:

or

Wherein, the structural formula of X is as follows:

Wherein, the value range of a is an integer ranging from 1 to 14, the value range of b is an integer ranging from 1 to 6, and the value range of c is an integer ranging from 13 to 68.

The silicone hydrogel material of Example 1 has good oxygen permeability, with an oxygen permeability value of at least 50 barrer, even higher than 150 barrer. In the silicon hydrogel material of Example 1, the macromolecular silicon monomer has a long chain of dimethylsiloxane. Since the long chain of dimethylsiloxane has a longer silicon-oxygen bond length and higher silicon-oxygen bond energy, and the bond angle of the Si-O-Si bond can vary in the range of 104°-180°, at the same time, due to The repulsion between the methyl group and the main chain makes the long chain of dimethylsiloxane loose and soft. This structure provides an excellent channel for oxygen transmission, which can directly transport oxygen in the air to the eyeball. The linear dimethylsiloxane chain structure is loose and the free volume is large. When the molecular weight is large, the silicone forms a continuous microphase region of a "honeycomb" structure, which is conducive to the transmission of oxygen. At the same time, the PEG chain is embedded in the macromolecular silicon monomer, which improves the compatibility between the macromolecular silicon monomer and the hydrophilic monomer. When the PEG chain is longer, the macromolecular silicon monomer has better compatibility with the hydrophilic monomer, and no organic solvent needs to be added. When the PEG chain is short, the compatibility between the macromolecular silicon monomer and the hydrophilic monomer becomes poor, and an organic solvent needs to be added to maintain the light transmittance of the lens.

As a preferred example, the small molecular silicon monomer includes methacryloxypropyl tris(trimethylsiloxane) silane (TRIS), methyl-bis(trimethylsiloxane)-silane Sylpropyl glyceryl methacrylate (SIGMA), 3-(methacryloxy)propyltrimethoxysilane (KH570), methacryloxymethyltris(trimethylsiloxy)silane ( MTTS) in one or any combination. Described hydrophilic monomer is N-vinylpyrrolidone (NVP), methacrylic acid (MMA), hydroxyethyl methacrylate (HEMA), N-vinyl-N methylacetamide (VMA), N - A combination of any two or more substances of vinylacetamide (NVA). The initiator is a photoinitiator or a thermal initiator. When the initiator is a photoinitiator, 2-hydroxyl-2-methylpropiophenone (D1173) is selected as the photoinitiator. When the initiator is a thermal initiator, one or a combination of azobisisobutyronitrile (AIBN) and benzoyl peroxide (BPO) is selected as the thermal initiator. The crosslinking agent is one or any combination of polyethylene glycol diacrylate (PEGDA), ethylene glycol dimethacrylate (EGDMA) or triallyl isocyanurate (TAIC). The organic solvent is one or any combination of isopropanol, ethanol, n-hexanol, n-butanol.

There are many methods for preparing the amphiphilic macromolecular silicon monomer in Example 1. The following two methods are preferred in this embodiment. The first method: under the action of a catalyst, polydimethylsiloxane terminated by hydroxyl and isocyanate (IEM) with methacrylic acid end group react to form siloxane in the temperature range of 20-80°C. Polymer. The specific chemical reaction formula is as follows:

The second method: polydimethylsiloxane terminated by hydroxyl groups and glycidyl ester (GMA), under the action of a catalyst, react in a temperature range of 20-80° C. to form siloxane oligomers. The specific chemical reaction formula is as follows:

Wherein, the structural formula of X is as follows:

In the above two preparation methods, the catalyst is dibutyltin dilaurate, trifluoromethanesulfonic acid, triethylamine or tetrabutylammonium chloride.

The following are six specific examples.

Example 1

Take 13g diol (the structural formula is shown in the following formula W1), 20mL chloroform, 0.1g catalyst dibutyltin dilaurate, 3.1g isocyanoethyl methacrylate (IEM), mix well, and heat to reflux at 50°C for 10h. After the reaction, wash with petroleum ether, let stand to separate layers, take the lower layer liquid and distill under reduced pressure to obtain transparent amphiphilic macromolecular silicon monomer, which is marked as M1-W1.

Example 2

Take 13g of diol (the structural formula is as shown in the above formula W1), 30mL of tetrahydrofuran, 2.8g of glycidyl methacrylate (GMA), 0.5g of trifluoromethanesulfonic acid, magnetic stirring, reflux at 60°C for 30min, and depressurize after the reaction Distillation to obtain a transparent amphiphilic macromolecular silicon monomer, denoted as M2-W1.

Example 3

Take 65.2g of diol (the structural formula is shown in the following formula W2), 20mL of chloroform, 0.3g of triethylamine, and 3.1g of isocyanoethyl methacrylate (IEM), mix well, and heat at reflux at 65°C for 3h. After the reaction, the obtained liquid was washed with petroleum ether, allowed to stand for stratification, and the lower layer liquid was distilled under reduced pressure to obtain a transparent amphiphilic macromolecular silicon monomer, which was denoted as M1-W2.

Example 4

Get 65.2g diol (structural formula is as shown in above formula W2), 2.8g glycidyl methacrylate (GMA), 0.5g tetrabutyl ammonium chloride, magnetic stirring, reflux reaction at room temperature 5h, underpressure distillation, obtain transparent two The hydrophilic macromolecular silicon monomer is denoted as M2-W2.

Example 5

Take 38.8g diol (the structural formula is shown in the following formula W3), 20mL chloroform, 0.2g catalyst dibutyltin dilaurate, 3.1g isocyanoethyl methacrylate (IEM), mix well, and heat to reflux at 50°C for 10h . After the reaction, wash with petroleum ether, let stand to separate layers, take the lower layer liquid and distill under reduced pressure to obtain transparent amphiphilic macromolecular silicon monomers, which are marked as M1-W3.

Example 6

Get 38.8g diol (structural formula is as shown in above formula W3), 2.8g glycidyl methacrylate (GMA), 0.2g tetrabutylammonium chloride, magnetic stirring, room temperature reflux reaction 5h, vacuum distillation, obtain transparent two The hydrophilic macromolecular silicon monomer is denoted as M2-W3.

Example 2

A kind of corneal contact lens, this corneal contact lens is made of silicon hydrogel material, and this silicon hydrogel material comprises the following component polymerization reaction according to the mass fraction:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

The contact lens of Example 2 has an anterior surface and a posterior surface, neither of which is unmodified. In the present invention, the organosilicon phase and the hydrogel intersect and run through each other, and the hydrophilicity of the hydrogel material makes it difficult to absorb lipids in tears, and has good anti-lipid precipitation performance, so no surface modification is required.

The lens is made from the silicone hydrogel material of Example 1. Since the silicone hydrogel material in Example 1 has good oxygen permeability, the corneal contact lens prepared by using this material also has good oxygen permeability.

The preparation method of the above-mentioned contact lens includes the following steps: mixing the components evenly, injecting them into the mold of the contact lens, photo-initiating or heat-initiating polymerization, then demoulding, extracting with deionized water to remove unpolymerized monomers and The oligomer is immersed in physiological saline to balance to obtain a contact lens; wherein, each component includes the following components according to weight percentage:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 3% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.1-3%.

As a preferred solution, while maintaining a certain water content and elongation at break of the lens, in order to obtain better oxygen permeability, the contact lens is formed by polymerizing the following components in parts by mass:

Initiators and crosslinkers;

Among them, the sum of the mass parts of amphiphilic macromolecular silicon monomer, small molecular silicon monomer, hydrophilic monomer and organic solvent is 100 parts; 0.1% to 2% of the sum of the weight of amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers and organic solvents; 0.5-3%.

The oxygen permeability of the corneal contact lens obtained by the above components is greater than 130*10 ^-11 .

The following experiments are conducted to verify that the contact lenses of the embodiments of the present invention have excellent water content and high oxygen permeability.

sample 1

Mix amphiphilic macromolecular silicon monomers, small molecular silicon monomers, hydrophilic monomers, organic solvents, initiators and crosslinking agents; inject them into contact lens molds, light-initiate or heat-initiate polymerization, and then remove The mold is extracted with deionized water to remove unpolymerized monomers and oligomers in the lens, and then immersed in physiological saline to equilibrate, thereby making a silicone hydrogel contact lens.

Wherein, the amphiphilic macromolecular silicon monomer adopts the amphiphilic macromolecular silicon monomer M1-w1 prepared in Example 1 and M2-w1 prepared in Example 2 above. The small molecule silicon monomer adopts methyl-bis(trimethylsiloxane)-silylpropyl glyceryl methacrylate (SIGMA), and the hydrophilic monomer adopts N-vinylpyrrolidone (NVP), methacrylic acid Hydroxyethyl ester (HEMA), N-vinyl-N methylacetamide (VMA), the initiator uses 2-hydroxy-2-methylpropiophenone (D1173), and the crosslinking agent uses polyethylene glycol diacrylate ( PEGDA).

Each component is shown in Table 1 in terms of parts by mass.

Samples 2-11

The preparation process of samples 2-11 contact lenses is the same as that of sample 1, the difference lies in the selection of each component material and the weight parts thereof, as shown in Table 1 for details.

Comparative sample

In a glass beaker, add 30 parts of methyl-bis(trimethylsiloxane)-silylpropyl glyceryl methacrylate, 22 parts of 2-hydroxyethyl methacrylate, 33 parts of N -vinylpyrrolidone, 6 parts of methacrylic acid, 0.1 part of polyethylene glycol diacrylate in the total mass of the monomer, 2 parts of azobisisobutyronitrile, mix well, inject the solution into a polypropylene mold, Polymerization was initiated thermally for 10 h. Then unmold. The dried sheet is soaked in deionized water, and then equilibrated in physiological saline to prepare a silicone hydrogel contact lens.

Table 1 sample proportioning (mass parts)

The elongation was measured by using an electronic tensile testing machine XLW (PC), and the contact lens sample was clamped with a splint for measurement, and the elongation at break of the contact lens sample was measured. The test results are shown in Table 2.

The moisture content is measured by weighing method, the weight of the glass slide is Q1, the weight of the lens and the glass slide is Q2, and the gross weight is G3 after drying in an oven at 50°C for 19 hours. Water content = (Q2-G3)/(Q2-Q1). The test results are shown in Table 2.

The national standard (GBT11417.3-2012) coulometric method was used to measure the oxygen permeability of each sample. The test results are shown in Table 2.

Table 2

It can be seen from Table 2 that the water content of the silicone hydrogel contact lenses of the samples of the present invention is all higher than 20%, the elongation at break is all higher than 150%, and the performance parameters meet the commercial standards. In particular, the oxygen permeability of the sample is more than 4 times higher than that of ordinary lenses, making the human eyeball comfortable to wear, especially the preparation process is simple, and no post-surface treatment is required.

Those skilled in the art should understand that the present invention is not limited by the above-mentioned specific examples. The descriptions in the above-mentioned specific examples and the description are only to further illustrate the principles of the present invention. Without departing from the spirit and scope of the present invention, the present invention The invention also has various changes and improvements, and these changes and improvements all fall within the scope of the claimed invention. The protection scope of the present invention is defined by the claims and their equivalents.

Claims (10)

1. have a silicone-hydrogel material for high oxygen permeability, it is characterized in that, this silicone-hydrogel material, according to mass fraction, comprises following component polyreaction and forms:

Wherein, the mass fraction sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent is 100 parts; Initiator accounts for 0.1 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent; Linking agent accounts for 0.1 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent.

2. according to the silicone-hydrogel material with high oxygen permeability according to claim 1, it is characterized in that, described amphiphilic macromolecular silicon monomer has the molecular formula of following structure:

or

Wherein, the structural formula of X is as follows:

Wherein, the span of a is the integer of 1 ~ 14, and the span of b is the integer of 1 ~ 6, and the span of c is the integer of 13 ~ 68.

3. according to the silicone-hydrogel material with high oxygen permeability according to claim 1, it is characterized in that, described small molecules silicon monomer comprises one in methacryloxypropyl three (trimethylsiloxane group) silane, methyl-two (trimethicone)-silylpropyl glyceral methacrylate, 3-(methacryloxypropyl) propyl trimethoxy silicane, methacryloxymethyl three (trimethylsiloxane group) silane or arbitrary combination.

4. according to the silicone-hydrogel material with high oxygen permeability according to claim 1, it is characterized in that, described hydrophilic monomer is NVP, two or more combinations of substances any in methacrylic acid, hydroxyethyl methylacrylate, N-vinyl-N methylacetamide, N-vinyl acetamide forms.

5. according to the silicone-hydrogel material with high oxygen permeability according to claim 1, it is characterized in that, described initiator is light trigger or thermal initiator; Described light trigger is 2-hydroxy-2-methyl Propiophenone, and thermal initiator is one in Diisopropyl azodicarboxylate and benzoyl peroxide or combination.

6. according to the silicone-hydrogel material with high oxygen permeability according to claim 1, it is characterized in that, described linking agent is one in polyethyleneglycol diacrylate, Ethylene glycol dimethacrylate or triallyl isocyanurate or arbitrary combination.

7. according to the silicone-hydrogel material with high oxygen permeability according to claim 1, it is characterized in that, described organic solvent is one in Virahol, ethanol, n-hexyl alcohol, propyl carbinol or arbitrary combination.

8. a contact lens, is characterized in that, this contact lens is obtained by silicone-hydrogel material, and this silicone-hydrogel material, according to mass fraction, comprises following component polyreaction and forms:

Wherein, the mass fraction sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent is 100 parts; Initiator accounts for 0.1 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent; Linking agent accounts for 0.1 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent.

9. according to contact lens according to claim 8, it is characterized in that, described silicone-hydrogel material, according to mass fraction, comprises following component polyreaction and forms:

Wherein, the mass fraction sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent is 100 parts; Initiator accounts for 0.1 ~ 2% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent; Linking agent accounts for 0.5 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent.

10. the preparation method of a contact lens, it is characterized in that, this preparation method comprises following process: each component mixed, inject contact lens mould, light-initiated or thermal-initiated polymerization, the then demoulding, unconverted monomer and oligopolymer in deionized water extraction removing eyeglass, immerse in physiological saline and balance, obtained contact lens; Wherein, described each component comprises following component according to mass fraction:

Wherein, the mass fraction sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent is 100 parts; Initiator accounts for 0.1 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent; Linking agent accounts for 0.1 ~ 3% of the weight sum of amphiphilic macromolecular silicon monomer, small molecules silicon monomer, hydrophilic monomer and organic solvent.