CN105412045A - Method for preparing Yimaikang micro-capsule - Google Patents
Method for preparing Yimaikang micro-capsule Download PDFInfo
- Publication number
- CN105412045A CN105412045A CN201510936600.3A CN201510936600A CN105412045A CN 105412045 A CN105412045 A CN 105412045A CN 201510936600 A CN201510936600 A CN 201510936600A CN 105412045 A CN105412045 A CN 105412045A
- Authority
- CN
- China
- Prior art keywords
- microcapsule
- yimaikanh
- phase
- gelatin
- cream powder
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5052—Proteins, e.g. albumin
- A61K9/5057—Gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Alternative & Traditional Medicine (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Medical Informatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a method for preparing a Yimaikang micro-capsule. The method comprises the following steps: putting gelatin into a compounding pot, adding water, heating at 70-80 DEG C to dissolve gelatin to obtain a gelatin solution, then adding erigeron breviscapus dry cream powder while stirring, and finally stirring with a homogenizer to dissolve erigeron breviscapus dry cream powder in the gelatin solution to prepare a water phase; putting liquid paraffin into the compounding pot, then adding span 80, heating to 70-80 DEG C, and uniformly mixing to prepare an oil phase; slowly adding the water phase into the oil phase to prepare a suspension; then adding isopropanol of which the volume is 6-8% of that of the suspension, performing still standing and filtering, and separating the solid phase from the liquid phase, wherein the solid phase is the micro-capsule. According to the method, the hygroscopicity of relevant preparations can be obviously reduced, and the stability of the finished product of the Yimaikang micro-capsule can be improved; the method is simple in process, low in production cost, low in energy consumption, and easy for industrialized production.
Description
Technical field
The present invention relates to a kind of preparation being used for the treatment of the pharmaceutical preparation intermediate of diseases of cardiovascular and cerebrovascular systems and peripheral neuropathy, especially a kind of preparation method of YIMAIKANH microcapsule.
Background technology
Herba Erigerontis is the dry herb of Compositae wingceltis thing Erigeron breviscapus (Vant.) Hand.-Mazz. Erigeronbreviscapus (Vant.) Hand.-Mazz..Modern pharmacological research shows: (1) Herba Erigerontis has significant anticoagulation, can reduce platelet count and suppress platelet aggregation, promoting the effect of Fibrinolytic Activities and body intravascular coagulation function, thus have anti thrombotic action; (2) Herba Erigerontis can make papaverine, reduces the neuronal damage of cerebral ischemia, thus diastole cerebrovascular and anti-cerebral ischemia; (3) Herba Erigerontis can improve microcirculation, increase coronary flow and obviously improve myocardial ischemia, blood-brain barrier permeability can be improved, antagonism adenosine diphosphate (ADP) causes platelet aggregation and improves macrophage phagocytic function, all has positive impact to the oxygen-derived free radicals of coronary heart disease and plasma fibrinolytic activity; (4) Herba Erigerontis passes through blood vessel dilating; improve and look nipple, retina blood circulation; improve the Activity of Cytochrome Oxidase of optic ganglion cell and the density of activity; free radical resisting and minimizing apoptosis; reduce retinal capillary permeability; improve optic nerve axonal transport and retina histopathology change after alleviating acute high intraocular pressure, to optic nerve injury, there is prevention and restitution, thus to green light optic nerve injury, there is protective effect.
Because having above-mentioned good drug effect, Herba Erigerontis medical material is used in a lot of Chinese patent medicine, wherein YIMAIKANH series of products are the single preparationss of ephedrine made with Herba Erigerontis dried cream powder, as YIMAIKANG PIAN, capsule, soft capsule, dispersible tablet, drop pill, etc., YIMAIKANG PIAN prescription the earliest records in the Sanitation Ministry medicine standard Traditional Chinese medicine historical preparation the 12 160 pages, and standard code is WS
3-B-2410-97, there is blood circulation promoting and blood stasis dispelling, be improved brain blood circulation, increase cerebral blood flow, increase the toleration of cardiac muscle to ischemia, anoxia, improve microcirculatory effect, clinical being mainly used in loses paralysis, eye ground vein obstruction, coronary heart disease after ischemic cerebrovascular and cerebral hemorrhage, vasculitic dermatosis, rheumatism.Ministry standard its preparation method is: get Herba Erigerontis extractum 160g, adds starch 150g and mixes, dry, pulverize below 75 DEG C, adds dextrin appropriate, makes granule, tabletting, sugar coating, to obtain final product with 60% ethanol.
Although have oral formulations, injection that above-mentioned multiple Herba Erigerontis is made, but due to reasons such as technologies of preparing, most of oral formulations also exists after taking that dissolve scattered time limit is long, dissolution is low, it is poor to absorb and the problem such as bioavailability is lower, particularly its hard capsule made, very easily become damp and rotten in production and storage process, thus affect the performance of drug effect, also directly affect the effect for the treatment of.In addition, Patients with Cardiovascular/Cerebrovascular Diseases needs long-term treatment, and life-time service injection is very inconvenient, manufacture and medical treatment cost high, patient economy burden weight shortcoming.Therefore, be necessary to prepare the not easily moisture absorption, be easy to the intermediate microcapsule that absorbs, to meet the multiple demand that clinical treatment and family use.
Summary of the invention
The present invention is directed to above-mentioned Problems existing, a kind of preparation method of YIMAIKANH microcapsule is provided.It is moist obviously can to reduce drawing of former granule after YIMAIKANH microencapsulation, increases mobility of particle, is easy to capsule charge or tabletting, and can improves the stability of YIMAIKANH final finished.This preparation method technique is simple, and production cost is low, consumes energy low, easily realizes suitability for industrialized production.
In order to realize above object, the present invention by the following technical solutions:
A preparation method for YIMAIKANH microcapsule, comprises the following steps:
1. take each raw material according to following parts by weight: Herba Erigerontis dried cream powder 100 parts, gelatin 100-120 part and water 1000-1200 part, gelatin is placed in ingredients pot, add water, at 70-80 DEG C, heating makes Gelatin, obtain gelatin solution, then add Herba Erigerontis dried cream powder, limit edged stirs, finally make Herba Erigerontis dried cream powder fully miscible in gelatin solution with homogenizer, make aqueous phase;
2. get liquid paraffin 100 parts and be placed in ingredients pot, then add sorbester p17 10-20 part, be heated to 70-80 DEG C, mixing, makes oil phase;
3. the temperature controlling described oil phase is 70-80 DEG C, and stir, slowly added in oil phase by described aqueous phase, described aqueous phase and the volume ratio of oil phase are: 100:100-120, continues to stir 3-5min, makes suspension;
4. starting circulating chilled water makes suspension be cooled to 5-7 DEG C rapidly, continues to stir 20-30min, then adds the isopropyl alcohol accounting for suspension cumulative volume 6-8%, stir 2-4min, leave standstill 20-24h;
5. after stratification, remove supernatant, remaining filtration, be separated solid liquid phase, solid phase is microcapsule, with isopropyl alcohol cleaning microcapsule surface, obtains solids, solids is dried 24-28h at 40-50 DEG C, obtain YIMAIKANH microcapsule.
Above-described Herba Erigerontis dried cream powder, for Herba Erigerontis medicinal substances extract, preferred preparation method is: get Herba Erigerontis medical material, and adding concentration is 60-75% ethanol, heating and refluxing extraction 2-3 time, each 1-2 hour, filters, and filtrate reduced in volume is extremely without alcohol taste, filter, filtrate is condensed into extractum, dry, obtains Herba Erigerontis dried cream powder.
Preferably, moisture≤6% of above-described Herba Erigerontis dried cream powder.
Preferably, the mixing speed of the above step 3, step 4 is 700-900rpm.
The molecular formula of above-described sorbester p17 is C
24h
44o
6, call as sorbitan mono-oleic acid ester, sorbitan monooleate, (Z)-mono--9-octadecenic acid Isosorbide Dinitrate, emulsifying agent S80 and sorbitan monooleate.Sorbester p17 is insoluble in water, is dissolved in deep fat and organic solvent, is senior lipophilic emulsifier, is mainly used in medicine, cosmetics, weaving, paint and petroleum industry etc., as emulsifying agent, thickening agent, antirust agent etc.
The microcapsule that the preparation method of the above YIMAIKANH microcapsule is made, described microcapsule can be used for the production of any dosage form, is preferred for the production of capsule, tablet.
Compared with prior art, beneficial effect of the present invention:
1, the inventive method is moist by obviously reducing drawing of former granule after YIMAIKANH microencapsulation, and drug manufacture and storage process are not easily become damp and rotten, can improve YIMAIKANH medicine stability, microcapsule good fluidity, be beneficial to preparation produce.
2, the inventive method will have certain slow controlled release properties after YIMAIKANH microcapsule, obvious reduction compared with the YIMAIKANG PIAN of release and routine or YIMAIKANH capsule formulation, drug release is slow and steady, both medicine can have been prevented at gastric inactivation or reduced zest to stomach, the bioavailability of medicine can have been improved again.
3, the present invention is using gelatin as microcapsule wall material, and have good film property, emulsifying and stability, consumption is few, cheap.
4, the envelop rate of YIMAIKANH microcapsule that the inventive method obtains reaches more than 90%, and drug loading is greater than 40%, and microcapsule yield is greater than 95%, illustrates that preparation technology of the present invention is feasible, reliable.
5, the technique of the inventive method simply, easily operate, consume energy low, save time, production cost is low, easily realizes suitability for industrialized production.
Detailed description of the invention
Below in conjunction with detailed description of the invention, the present invention is further described, but be not limited to protection scope of the present invention.
One, the preparation of Herba Erigerontis dried cream powder
Embodiment 1
Get Herba Erigerontis medical material 2000 parts, be ground into coarse powder, adding 16000 parts of concentration is 75% ethanol, heating and refluxing extraction 3 times, each 1 hour, filter, filtrate is evaporated to without alcohol taste at 65 DEG C, filters, filtrate is condensed into extractum, drying under reduced pressure at 90 DEG C, moisture is reduced to 6%, obtains Herba Erigerontis dried cream powder.
Embodiment 2
Get Herba Erigerontis medical material 2000 parts, be ground into coarse powder, adding 14000 parts of concentration is 70% ethanol, heating and refluxing extraction 2 times, each 1.5 hours, filter, filtrate is evaporated to without alcohol taste at 60 DEG C, filters, filtrate is condensed into extractum, drying under reduced pressure at 85 DEG C, moisture is reduced to 5%, obtains Herba Erigerontis dried cream powder.
Embodiment 3
Get Herba Erigerontis medical material 2000 parts, be ground into coarse powder, adding 12000 parts of concentration is 65% ethanol, heating and refluxing extraction 2 times, each 2 hours, filter, filtrate is evaporated to without alcohol taste at 70 DEG C, filters, filtrate is condensed into extractum, drying under reduced pressure at 80 DEG C, moisture is reduced to 5.5%, obtains Herba Erigerontis dried cream powder.
Two, the preparation of YIMAIKANH microcapsule
Embodiment 4
A preparation method for YIMAIKANH microcapsule, comprises the following steps:
1. take each raw material according to following parts by weight: Example 1 Herba Erigerontis dried cream powder 100 parts, 100 parts, gelatin and 1000 parts, water, gelatin is placed in ingredients pot, add water, at 75 DEG C, heating makes Gelatin, obtain gelatin solution, then add Herba Erigerontis dried cream powder, limit edged stirs, finally make Herba Erigerontis dried cream powder fully miscible in gelatin solution with homogenizer, make aqueous phase;
2. get liquid paraffin 100 parts and be placed in ingredients pot, then add sorbester p17 10 parts, be heated to 70 DEG C, mixing, makes oil phase;
3. the temperature controlling described oil phase is 70 DEG C, and stir, slowly added in oil phase by described aqueous phase, described aqueous phase and the volume ratio of oil phase are 100:100, continues to stir 5min, makes suspension;
4. starting circulating chilled water makes suspension be cooled to rapidly 5 DEG C, continues to stir 20min, then adds the isopropyl alcohol accounting for suspension cumulative volume 7%, stir 2min, leave standstill 24h;
5. stratification, removes supernatant, remaining filtration, and be separated solid liquid phase, solid phase is microcapsule, with isopropyl alcohol cleaning microcapsule surface, obtains solids, solids is dried 28h at 40 DEG C, obtain YIMAIKANH microcapsule.
Embodiment 5
A preparation method for YIMAIKANH microcapsule, comprises the following steps:
1. take each raw material according to following parts by weight: Example 2 Herba Erigerontis dried cream powder 100 parts, 120 parts, gelatin and 1000 parts, water, gelatin is placed in ingredients pot, add water, at 70 DEG C, heating makes Gelatin, obtain gelatin solution, then add Herba Erigerontis dried cream powder, limit edged stirs, finally make Herba Erigerontis dried cream powder fully miscible in gelatin solution with homogenizer, make aqueous phase;
2. get liquid paraffin 100 parts and be placed in ingredients pot, then add sorbester p17 10 parts, be heated to 70 DEG C, mixing, makes oil phase;
3. the temperature controlling described oil phase is 70 DEG C, and stir, slowly added in oil phase by described aqueous phase, described aqueous phase and the volume ratio of oil phase are: 100:120, continues to stir 3min, makes suspension;
4. starting circulating chilled water makes suspension be cooled to rapidly 5 DEG C, continues to stir 25min, then adds the isopropyl alcohol accounting for suspension cumulative volume 8%, stir 2min, leave standstill 22h, obtain standing liquid;
5. stratification, removes supernatant, remaining filtration, and be separated solid liquid phase, solid phase is microcapsule, with isopropyl alcohol cleaning microcapsule surface, obtains solids, solids is dried 24h at 45 DEG C, obtain YIMAIKANH microcapsule.
Embodiment 6
A preparation method for YIMAIKANH microcapsule, comprises the following steps:
1. take each raw material according to following parts by weight: Example 3 Herba Erigerontis dried cream powder 100 parts, 100 parts, gelatin and 1200 parts, water, gelatin is placed in ingredients pot, add water, at 80 DEG C, heating makes Gelatin, obtain gelatin solution, then add Herba Erigerontis dried cream powder, limit edged stirs, finally make Herba Erigerontis dried cream powder fully miscible in gelatin solution with homogenizer, make aqueous phase;
2. get liquid paraffin 100 parts and be placed in ingredients pot, then add sorbester p17 20 parts, be heated to 80 DEG C, mixing, makes oil phase;
3. the temperature controlling described oil phase is 80 DEG C, and stir, slowly added in oil phase by described aqueous phase, described aqueous phase and the volume ratio of oil phase are: 100:120, continues to stir 5min, makes suspension;
4. starting circulating chilled water makes suspension be cooled to rapidly 7 DEG C, continues to stir 30min, then adds the isopropyl alcohol accounting for suspension cumulative volume 6%, stir 4min, leave standstill 20h, obtain standing liquid;
5. stratification, removes supernatant, remaining filtration, and be separated solid liquid phase, solid phase is microcapsule, with isopropyl alcohol cleaning microcapsule surface, obtains solids, solids is dried 24h at 50 DEG C, obtain YIMAIKANH microcapsule.
Three, the quality evaluation of YIMAIKANH microcapsule
1. measure the envelop rate of YIMAIKANH microcapsule
Employing ultraviolet spectrophotometry detects.Content × 100% of encapsulating and non-encapsulated flavone compound in the quality/microcapsule of the flavone compound encapsulated in envelop rate=microcapsule.Be reference substance with rutin, be diluted to 500mg/L.The each 50mg of YIMAIKANH microcapsule of Example 4-6, uses 100mL dissolve with methanol, then uses ultrasonic Treatment 30min respectively, filters, gets filtrate.Measure absorbance at 510nm place, then computational envelope rate, the results are shown in Table 1.
The envelop rate situation of table 1 embodiment 4-6 YIMAIKANH microcapsule
| Embodiment | Envelop rate (%) |
| Embodiment 4 | 91.25 |
| Embodiment 5 | 93.47 |
| Embodiment 6 | 90.09 |
As can be seen from the table, the envelop rate of YIMAIKANH microcapsule of the present invention all reaches more than 90%.
2. measure the drug loading of YIMAIKANH microcapsule
Take each 5g of YIMAIKANH microcapsule of embodiment 4-6 respectively, add the ultrasonic 20min of 50ml water, add petroleum ether (60-90 DEG C) and carry out extraction 2 times, each 50ml, filter, merge petroleum ether layer, be placed on single port bottle and revolve steaming, then the drying baker being placed on 105 DEG C is dried, the single port bottle of drying is placed in vacuum desiccator, be cooled to room temperature, weigh, calculate the weight of Herba Erigerontis dried cream powder inside microcapsule in single port bottle, according to formula: Herba Erigerontis dried cream powder weight/YIMAIKANH microcapsule weight × 100% inside drug loading (%)=microcapsule, calculate drug loading, result of calculation is in table 2.
The drug loading situation of table 2 embodiment 4-6 YIMAIKANH microcapsule
| Embodiment | Drug loading (%) |
| Embodiment 1 | 43.03 |
| Embodiment 2 | 46.78 |
| Embodiment 3 | 41.94 |
3. measure the release of microcapsule
Get embodiment of the present invention 4-6 sample and commercially available YIMAIKANH capsule, commercially available YIMAIKANG PIAN respectively, according to Chinese Pharmacopoeia 2015 editions drug release determination methods (annex XD first method), according to the release of method time-and-motion study YIMAIKANH microcapsule described in 2.4.Leaching condition: 37 ± 0.5 DEG C, rotating speed 80rpm, samples at 10min, 20min, 40min, 80min respectively.Detect general flavone content according to entrapment efficiency determination method, reagent adds complete beginning timing, and 10min starts to measure, and METHOD FOR CONTINUOUS DETERMINATION 80min, measurement result is as shown in table 3.
Table 3 drug release rate situation
| 10min | 20min | 40min | 80min | |
| Embodiment 4 | 12.5 | 25.8 | 38.7 | 50.4 |
| Embodiment 5 | 11.5 | 22.7 | 36.4 | 48.5 |
| Embodiment 6 | 12.2 | 24.4 | 39.4 | 53.9 |
| Commercially available YIMAIKANH capsule | 56.8 | 65.4 | 76.2 | 90.7 |
| Commercially available YIMAIKANG PIAN | 45.3 | 55.8 | 68.7 | 82.9 |
As can be seen from the table, slowly, its slow controlled-release effect is obvious for the commercially available capsule that YIMAIKANH microcapsule release ratio adopts common method for making to make and tablet.
Four, the preparation of YIMAIKANH capsule
Embodiment 7
The YIMAIKANH microcapsule 3.2kg of Example 4, adds starch 2.8kg, then adds appropriate Pulvis Talci, mix homogeneously, incapsulate, be i.e. benefit arteries and veins recovering capsule.
Embodiment 8
The YIMAIKANH microcapsule 3.2kg of Example 5, adds starch 2.8kg, then adds appropriate Pulvis Talci, mix homogeneously, incapsulate, be i.e. benefit arteries and veins recovering capsule.
Five, the preparation of YIMAIKANG PIAN
Embodiment 9
The 1.6kg of the YIMAIKANH microcapsule of Example 6, adds starch 1.5kg, then it is appropriate to add dextrin, makes granule, tabletting, sugar coating, obtain YIMAIKANG PIAN with 60% ethanol.
Six, determination of water
Get embodiment of the present invention 7-9 and commercially available YIMAIKANG PIAN, YIMAIKANH capsule, put stability test case, under temperature 40 DEG C ± 2 DEG C, relative humidity 75% ± 5% condition, carry out 6 months accelerated tests, check according under " Chinese Pharmacopoeia " version in 2015 annex moisture item, refer to table 4.
Table 4 determination of water result table
| 0 month | January | February | March | June | |
| Embodiment 7 | 4.8％ | 4.9％ | 5.1％ | 5.3％ | 5.4％ |
| Embodiment 8 | 4.6％ | 4.8％ | 4.9％ | 5.0％ | 5.1％ |
| Embodiment 9 | 5.0％ | 5.2％ | 5.4％ | 5.5％ | 5.6％ |
| Commercially available YIMAIKANH capsule | 6.8％ | 7.2％ | 7.8％ | 8.0％ | 9.2％ |
| Commercially available YIMAIKANG PIAN | 6.5％ | 7.0％ | 7.4％ | 7.8％ | 8.1％ |
Result of the test shows: YIMAIKANH capsule prepared by the present invention and tablet, compared with commercially available YIMAIKANH capsule and YIMAIKANG PIAN, medicine draw moist obvious reduction, solve medicine and producing and the problem that very easily becomes damp and rotten of storage process.
Above content can not assert that specific embodiment of the invention is confined to these explanations; for general technical staff of the technical field of the invention; without departing from the inventive concept of the premise; some simple deduction or replace can also be made, all should be considered as belonging to the scope of patent protection that the present invention is determined by submitted to claims.
Claims (4)
1. a preparation method for YIMAIKANH microcapsule, is characterized in that, comprises the following steps:
(1) each raw material is taken according to following parts by weight: Herba Erigerontis dried cream powder 100 parts, gelatin 100-120 part and water 1000-1200 part, gelatin is placed in ingredients pot, add water, at 70-80 DEG C, heating makes Gelatin, obtain gelatin solution, then add Herba Erigerontis dried cream powder, limit edged stirs, finally make Herba Erigerontis dried cream powder fully miscible in gelatin solution with homogenizer, make aqueous phase;
(2) get liquid paraffin 100 parts and be placed in ingredients pot, then add sorbester p17 10-20 part, be heated to 70-80 DEG C, mixing, makes oil phase;
(3) temperature controlling described oil phase is 70-80 DEG C, and stir, slowly added in oil phase by described aqueous phase, described aqueous phase and the volume ratio of oil phase are: 100:100-120, continues to stir 3-5min, makes suspension;
(4) starting circulating chilled water makes suspension be cooled to 5-7 DEG C rapidly, continues to stir 20-30min, then adds the isopropyl alcohol accounting for suspension cumulative volume 6-8%, stir 2-4min, leave standstill 20-24h;
(5) remove supernatant, remaining filtration, be separated solid liquid phase, solid phase is microcapsule, with isopropyl alcohol cleaning microcapsule surface, obtains solids, solids is dried 24-28h at 40-50 DEG C, obtain YIMAIKANH microcapsule.
2. the preparation method of YIMAIKANH microcapsule according to claim 1, is characterized in that: moisture≤6% of described Herba Erigerontis dried cream powder.
3. the preparation method of YIMAIKANH microcapsule according to claim 1, is characterized in that: the mixing speed of described step (3), (4) is 700-900rpm.
4. the microcapsule made of the preparation method of YIMAIKANH microcapsule as claimed in claim 1, is characterized in that: described microcapsule is used for the production of capsule, tablet.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510936600.3A CN105412045B (en) | 2015-12-15 | 2015-12-15 | A kind of preparation method of benefit arteries and veins health micro-capsule |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510936600.3A CN105412045B (en) | 2015-12-15 | 2015-12-15 | A kind of preparation method of benefit arteries and veins health micro-capsule |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105412045A true CN105412045A (en) | 2016-03-23 |
| CN105412045B CN105412045B (en) | 2018-08-24 |
Family
ID=55490902
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510936600.3A Active CN105412045B (en) | 2015-12-15 | 2015-12-15 | A kind of preparation method of benefit arteries and veins health micro-capsule |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105412045B (en) |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626208A (en) * | 2004-08-13 | 2005-06-15 | 贵阳云岩西创药物科技开发有限公司 | Preparation of fleabane and preparation method |
| CN1775868A (en) * | 2005-11-24 | 2006-05-24 | 山东省科学院生物研究所 | A kind of water-dispersible capsanthin microcapsule and preparation method thereof |
| CN1853660A (en) * | 2004-08-13 | 2006-11-01 | 贵阳云岩西创药物科技开发有限公司 | Erigeron breviscapus preparation and making method thereof |
-
2015
- 2015-12-15 CN CN201510936600.3A patent/CN105412045B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1626208A (en) * | 2004-08-13 | 2005-06-15 | 贵阳云岩西创药物科技开发有限公司 | Preparation of fleabane and preparation method |
| CN1853660A (en) * | 2004-08-13 | 2006-11-01 | 贵阳云岩西创药物科技开发有限公司 | Erigeron breviscapus preparation and making method thereof |
| CN1775868A (en) * | 2005-11-24 | 2006-05-24 | 山东省科学院生物研究所 | A kind of water-dispersible capsanthin microcapsule and preparation method thereof |
Non-Patent Citations (4)
| Title |
|---|
| DMITRY V. VOLODKIN ETAL: "Matrix Polyelectrolyte Microcapsules: New System for Macromolecule Encapsulation", 《LANGMUIR THE ACS JOURNAL OF SURFACES & COLLOIDS》 * |
| 李威等主编: "《药剂学》", 28 February 2014 * |
| 杨瑞虹主编: "《药物制剂技术与设备》", 31 August 2010 * |
| 蔡津生等编著: "《中国食药用菌工程学》", 31 January 2015 * |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105412045B (en) | 2018-08-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104127761A (en) | Children's soft preparation for strengthening stomach and promoting digestion and preparation method thereof | |
| CN102423352A (en) | A Chinese medicinal granule for treating cardiovascular and cerebrovascular diseases | |
| CN100577158C (en) | Preparation method and application of vine tea dispersible tablet | |
| CN102755405B (en) | Fructus crataegi leaf water extract, preparation containing same and preparation method pf fructus crataegi leaf water extract | |
| CN101703592B (en) | Medicament for treating coronary disease and stenocardia and preparation method thereof | |
| CN105477093A (en) | Preparation method of micro-capsules for treating rheumatism | |
| CN102716135A (en) | Application of lupenone to products for preventing or treating diabetes mellitus | |
| CN105412045A (en) | Method for preparing Yimaikang micro-capsule | |
| CN102552208B (en) | Daidzein solid dispersion micro-pill capsule and preparation method thereof | |
| CN101032534B (en) | Method of preparing Ilex rotunda Thunb total saponins and the application thereof | |
| CN105343723A (en) | Preparation method of Juyuan cough relieving micro-capsule | |
| CN104352427A (en) | Pharmaceutical composition containing andrographolide and use of pharmaceutical composition | |
| CN104857180B (en) | Composition for resisting fatigue and improving immunity and preparation method and application thereof | |
| CN107080240A (en) | A kind of health food conditioner for alleviating qi depression to blood stasis and preparation method thereof | |
| CN101961340B (en) | Application of pedunculoside in preparing medicine for treating coronary heart disease | |
| CN104983761A (en) | Acanthopanax senticosus leaf general flavone phospholipid complex and preparing method and preparation thereof | |
| CN107496510B (en) | Cyclocarya paliurus capsule and preparation method thereof | |
| CN100441195C (en) | Medicinal composition containing safflower total flavone and its preparation process and usage | |
| CN105982998B (en) | A kind of pharmaceutical composition and its preparation method and application for treating fatty liver | |
| CN101982175B (en) | Application of pedunculoside in preparing medicine for treating cerebral ischemia | |
| CN102000168B (en) | Medicament for reducing blood sugar | |
| CN100363009C (en) | Microcapsule for preventing and curing tumour and production method thereof | |
| CN101244041A (en) | A kind of medicine for preventing and treating acute liver injury and preparation method thereof | |
| CN1875979B (en) | Soft capsule of hippophae rhamnoides and preparation process thereof | |
| CN105963389A (en) | Separation method and application of high altitude anoxia-induced fatigue-resistant active ingredient in gardenia jasminoides ellis |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |