CN105411959A - Healthcare toothpaste containing traditional Chinese herbals and preparation method thereof - Google Patents
Healthcare toothpaste containing traditional Chinese herbals and preparation method thereof Download PDFInfo
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- CN105411959A CN105411959A CN201511023228.3A CN201511023228A CN105411959A CN 105411959 A CN105411959 A CN 105411959A CN 201511023228 A CN201511023228 A CN 201511023228A CN 105411959 A CN105411959 A CN 105411959A
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- 239000000606 toothpaste Substances 0.000 title claims abstract description 79
- 229940034610 toothpaste Drugs 0.000 title claims abstract description 79
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 239000000284 extract Substances 0.000 claims abstract description 102
- 239000002994 raw material Substances 0.000 claims abstract description 63
- 239000003795 chemical substances by application Substances 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000012752 auxiliary agent Substances 0.000 claims abstract description 28
- PUKLDDOGISCFCP-JSQCKWNTSA-N 21-Deoxycortisone Chemical compound C1CC2=CC(=O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)C)(O)[C@@]1(C)CC2=O PUKLDDOGISCFCP-JSQCKWNTSA-N 0.000 claims abstract description 23
- 229910021532 Calcite Inorganic materials 0.000 claims abstract description 23
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims abstract description 23
- FCYKAQOGGFGCMD-UHFFFAOYSA-N Fulvic acid Natural products O1C2=CC(O)=C(O)C(C(O)=O)=C2C(=O)C2=C1CC(C)(O)OC2 FCYKAQOGGFGCMD-UHFFFAOYSA-N 0.000 claims abstract description 23
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims abstract description 23
- 239000000796 flavoring agent Substances 0.000 claims abstract description 23
- 235000013355 food flavoring agent Nutrition 0.000 claims abstract description 23
- 229940095100 fulvic acid Drugs 0.000 claims abstract description 23
- 239000002509 fulvic acid Substances 0.000 claims abstract description 23
- 229940042585 tocopherol acetate Drugs 0.000 claims abstract description 23
- 235000006484 Paeonia officinalis Nutrition 0.000 claims abstract description 21
- 239000004088 foaming agent Substances 0.000 claims abstract description 11
- 239000003381 stabilizer Substances 0.000 claims abstract description 11
- 230000002087 whitening effect Effects 0.000 claims abstract description 11
- 239000003906 humectant Substances 0.000 claims abstract description 3
- 239000000843 powder Substances 0.000 claims description 90
- 239000003814 drug Substances 0.000 claims description 75
- 241000628997 Flos Species 0.000 claims description 62
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 54
- 238000003756 stirring Methods 0.000 claims description 45
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 36
- 241000411851 herbal medicine Species 0.000 claims description 32
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 31
- 241000180649 Panax notoginseng Species 0.000 claims description 31
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 30
- 239000000706 filtrate Substances 0.000 claims description 27
- 239000013521 mastic Substances 0.000 claims description 27
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 25
- 239000000047 product Substances 0.000 claims description 25
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 22
- 241000736199 Paeonia Species 0.000 claims description 20
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 20
- 238000004140 cleaning Methods 0.000 claims description 20
- 238000013019 agitation Methods 0.000 claims description 18
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- 238000002481 ethanol extraction Methods 0.000 claims description 18
- 239000003292 glue Substances 0.000 claims description 18
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- AFHJQYHRLPMKHU-XXWVOBANSA-N Aloin Natural products O=C1c2c(O)cc(CO)cc2[C@H]([C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O2)c2c1c(O)ccc2 AFHJQYHRLPMKHU-XXWVOBANSA-N 0.000 claims description 16
- 239000004366 Glucose oxidase Substances 0.000 claims description 16
- 108010015776 Glucose oxidase Proteins 0.000 claims description 16
- 239000004378 Glycyrrhizin Substances 0.000 claims description 16
- FENRSEGZMITUEF-ATTCVCFYSA-E [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].OP(=O)([O-])O[C@@H]1[C@@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H](OP(=O)([O-])[O-])[C@H](OP(=O)(O)[O-])[C@H]1OP(=O)([O-])[O-] FENRSEGZMITUEF-ATTCVCFYSA-E 0.000 claims description 16
- CPUHNROBVJNNPW-UHFFFAOYSA-N aloin A Natural products OC1C(O)C(O)C(CO)OC1OC1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 CPUHNROBVJNNPW-UHFFFAOYSA-N 0.000 claims description 16
- AFHJQYHRLPMKHU-WEZNYRQKSA-N aloin B Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1[C@H]1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-WEZNYRQKSA-N 0.000 claims description 16
- 235000019420 glucose oxidase Nutrition 0.000 claims description 16
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- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 claims description 16
- 229960004949 glycyrrhizic acid Drugs 0.000 claims description 16
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 claims description 16
- 235000019410 glycyrrhizin Nutrition 0.000 claims description 16
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 claims description 16
- AFHJQYHRLPMKHU-UHFFFAOYSA-N isobarbaloin Natural products OC1C(O)C(O)C(CO)OC1C1C2=CC(CO)=CC(O)=C2C(=O)C2=C(O)C=CC=C21 AFHJQYHRLPMKHU-UHFFFAOYSA-N 0.000 claims description 16
- 229940083982 sodium phytate Drugs 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 15
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 14
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 claims description 12
- 235000017858 Laurus nobilis Nutrition 0.000 claims description 10
- 108010077895 Sarcosine Proteins 0.000 claims description 10
- 244000125380 Terminalia tomentosa Species 0.000 claims description 10
- 235000005212 Terminalia tomentosa Nutrition 0.000 claims description 10
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- 239000000377 silicon dioxide Substances 0.000 claims description 10
- 235000012239 silicon dioxide Nutrition 0.000 claims description 10
- 229940048098 sodium sarcosinate Drugs 0.000 claims description 10
- ZUFONQSOSYEWCN-UHFFFAOYSA-M sodium;2-(methylamino)acetate Chemical compound [Na+].CNCC([O-])=O ZUFONQSOSYEWCN-UHFFFAOYSA-M 0.000 claims description 10
- 239000012141 concentrate Substances 0.000 claims description 9
- 230000001804 emulsifying effect Effects 0.000 claims description 9
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- 239000012535 impurity Substances 0.000 claims description 9
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- 239000006072 paste Substances 0.000 claims description 9
- -1 reflux Substances 0.000 claims description 9
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 8
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims description 8
- 235000019700 dicalcium phosphate Nutrition 0.000 claims description 8
- 239000000600 sorbitol Substances 0.000 claims description 8
- 239000000080 wetting agent Substances 0.000 claims description 8
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical group [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 7
- 235000010323 ascorbic acid Nutrition 0.000 claims description 7
- 229960005070 ascorbic acid Drugs 0.000 claims description 7
- 239000011668 ascorbic acid Substances 0.000 claims description 7
- 235000019333 sodium laurylsulphate Nutrition 0.000 claims description 7
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims description 6
- 239000001856 Ethyl cellulose Substances 0.000 claims description 6
- ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 claims description 6
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- 229920001249 ethyl cellulose Polymers 0.000 claims description 6
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 claims description 6
- 239000000230 xanthan gum Substances 0.000 claims description 4
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- 235000010493 xanthan gum Nutrition 0.000 claims description 4
- 229940082509 xanthan gum Drugs 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 2
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- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
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- 230000037213 diet Effects 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/678—Tocopherol, i.e. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cosmetics (AREA)
Abstract
The invention discloses a healthcare toothpaste containing traditional Chinese herbals and a preparation method thereof. The toothpaste comprises the following raw materials: auxiliary agent, calcite, fulvic acid, traditional Chinese herbal extract, saussurea involucrate extract, peony root extract, and vitamin E acetate, wherein the raw materials of the traditional Chinese herbal extract are pseudo-ginseng, honeysuckle flower, chamomile, licorice, radix scutellariae, mint, ajuga decumbens, cordate houttuynia, radix bupleuri, juncus roemerianus, and achyranthes root, and the auxiliary agent is composed of a friction agent, a humectant, water, a foaming agent, an adhesive, a flavoring agent, a sweetener, a stabilizing agent, and a whitening agent. The raw materials can generate a synergetic effect on clearing fire, removing toxin, removing internal heat and dampness, eliminating inflammation, and relieving pains. The preparation technology is simple and environment-friendly. The toothpaste does not have any side or toxic effect, has the basic functions of toothpaste, also has the functions of preventing excess inner heat and allergy, and is capable of rapidly relieving pains and allergy of tooth, protecting oral tissues, and nourishing gum if people use the toothpaste regularly for a long term.
Description
Technical field
The present invention relates to new material technology field, specifically a kind of health-care toothpaste containing Chinese herbal medicine and preparation method thereof.
Background technology
The adult of China 90% has oral problem in various degree, the medical statistics data of specialty find along with the change (numb, peppery, boiling hot) of dietary habit and the increase of operating pressure, oral ulcer, tooth open swell and ache, the oral problem such as hemorrhage, atrophy spreads just fast.These oral cavities " minor issue ", although be not enough to hospital, greatly perplexed the emotion of people, have been thereby produced the consumption demand for oral problem.Intraoral Periodontal Supporting Tissue is subject to local excitation simultaneously, as tartar, food impaction, ill fitting prosthesis etc., it is excessive that the uneven and incorrect method for brushing teeth of long-term mechanical stimulus, denture makes part dental articulation power bear, and chemicals, burn, hypovitaminosis C, oral cavity bacterium growth etc. cause the oral cavity commonly encountered diseases such as gingivitis, periodontitis and alveolar abscess.
Toothpaste is used from cleaning teeth with toothbrush one, and protection oral hygiene, to a kind of daily necessities of human-body safety.Along with the raising of people's living standard, the quality requirement of toothpaste is also progressively improved.At aspect of performance General Requirements toothpaste: the thin film of dental surface and bacterial plaque can be removed and do not damage enamel and dentin; There is good cleaning oral cavity and effect around thereof; Avirulence, non-stimulated to oral mucosa; There are comfortable fragrance and taste, after using, have cool and sweet-smelling sensation.
In toothpaste, add effective medicine can prevent and treat the various oral diseases that antibacterial or virus causes.Antibiotic can be effectively antibacterial, but due to side effect comparatively large, the main flow on market or Chinese medicinal toothpaste.But the interpolation of the effective ingredient in Chinese medicinal toothpaste in toothpaste has randomness, has plenty of the suggestion according to Chinese medicine personage, has plenty of according to folk remedy, have plenty of according to some Chinese herbal medicine in well-known degree among the people etc., seldom through Experimental Comparison.
Summary of the invention
The object of the present invention is to provide a kind of health-care toothpaste containing Chinese herbal medicine and preparation method thereof.
For achieving the above object, the invention provides following technical scheme:
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 80-100 part, calcite 20-30 part, fulvic acid 8-12 part, Chinese medicine extract 2-4 part, Herba Saussureae Involueratae extract 1-3 part, peony root extractive 1-3 part, Vitamin E acetate 0.5-1 part; Described Chinese medicine extract is made up of the raw material of following weight portion: Radix Notoginseng 10-20 part, Flos Lonicerae 10-20 part, Flos Matricariae chamomillae 10-20 part, Radix Glycyrrhizae 8-12 part, Radix Scutellariae 8-12 part, Herba Menthae 3-5 part, Herba Ajugae 3-5 part, Herba Houttuyniae 2-4 part, Radix Bupleuri 2-4 part, Medulla Junci 1-3 part, Radix Achyranthis Bidentatae 1-3 part; Described auxiliary agent is made up of the raw material of following weight portion: abrasivus 30-40 part, wetting agent 30-33 part, water 17-19 part, foaming agent 1-3 part, binding agent 1-2 part, flavouring agent 0.5-1.5 part, sweeting agent 0.1-0.3 part, stabilizing agent 0.1-0.2 part, whitening agent 0.3-1 part.
As the further scheme of the present invention: the described health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 84.27-95.73 part, calcite 22-28 part, fulvic acid 9-11 part, Chinese medicine extract 2.5-3.5 part, Herba Saussureae Involueratae extract 1.5-2.5 part, peony root extractive 1.5-2.5 part, Vitamin E acetate 0.6-0.9 part; Described Chinese medicine extract is made up of the raw material of following weight portion: Radix Notoginseng 12-18 part, Flos Lonicerae 12-18 part, Flos Matricariae chamomillae 12-18 part, Radix Glycyrrhizae 9-11 part, Radix Scutellariae 9-11 part, Herba Menthae 3.5-4.5 part, Herba Ajugae 3.5-4.5 part, Herba Houttuyniae 2.5-3.5 part, Radix Bupleuri 2.5-3.5 part, Medulla Junci 1.5-2.5 part, Radix Achyranthis Bidentatae 1.5-2.5 part; Described auxiliary agent is made up of the raw material of following weight portion: abrasivus 32-38 part, wetting agent 30.5-32.5 part, water 17.5-18.5 part, foaming agent 1.5-2.5 part, binding agent 1.2-1.8 part, flavouring agent 0.8-1.2 part, sweeting agent 0.15-0.25 part, stabilizing agent 0.12-0.18 part, whitening agent 0.5-0.8 part.
As the further scheme of the present invention: the described health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 89.45 parts, 25 parts, calcite, fulvic acid 10 parts, Chinese medicine extract 3 parts, Herba Saussureae Involueratae extract 2 parts, peony root extractive 2 parts, Vitamin E acetate 0.8 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 15 parts, Radix Notoginseng, Flos Lonicerae 15 parts, Flos Matricariae chamomillae 15 parts, 10 parts, Radix Glycyrrhizae, Radix Scutellariae 10 parts, Herba Menthae 4 parts, Herba Ajugae 4 parts, Herba Houttuyniae 3 parts, Radix Bupleuri 3 parts, Medulla Junci 2 parts, Radix Achyranthis Bidentatae 2 parts; Described auxiliary agent is made up of the raw material of following weight portion: abrasivus 35 parts, wetting agent 31 parts, 18 parts, water, foaming agent 2 parts, binding agent 1.5 parts, flavouring agent 1 part, sweeting agent 0.2 part, stabilizing agent 0.15 part, whitening agent 0.6 part.
As the further scheme of the present invention: described wetting agent is one or more in glycerol, sorbitol, propylene glycol.
As the further scheme of the present invention: described binding agent is one or more in carboxymethyl cellulose, light ethyl cellulose, xanthan gum, carrageenan.
As the further scheme of the present invention: described foaming agent is sodium laurylsulfate or Laurel acidic group sodium sarcosinate.
As the further scheme of the present invention: described abrasivus is calcium hydrogen phosphate or silicon dioxide.
As the further scheme of the present invention: described stabilizing agent is ascorbic acid or citric acid.
As the present invention's further scheme: described whitening agent comprises sodium phytate, aloin, glycyrrhizin and glucoseoxidase.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 80-100 mesh sieve was pulverized; Be after the soak with ethanol 2-3h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3-4h, filter, filtering residue repeats reflux, extract, 2-3 time, merge ethanol extraction filtrates, wherein the addition of ethanol is 2-3 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 120-140 mesh sieve, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, after dry, co-grinding is to 50-70 order, ethyl acetate crushed material being placed in 14-16 times of equivalent stirs 5-6h at 50-60 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 120-140 order, obtains Chinese medicine extraction powder B for subsequent use;
(4) humectant of going bail for is placed in container, under agitation, adds binding agent, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 2-4min, obtain the glue of transparent and homogeneous;
(5) abrasivus, stabilizing agent and whitening agent are added in the glue of above-mentioned storage, first slowly stir, after whole dispersions, improve rotating speed, till uniformly body of paste, then add foaming agent, flavouring agent and sweeting agent, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 5-7min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Compared with prior art, the invention has the beneficial effects as follows:
In the present invention, each raw material synergism plays the effect with Qinghuo Jiedu, clearing away heat-damp and promoting diuresis, anti-inflammatory analgesic; preparation technology is simple, environmentally friendly; there is no toxic and side effects; clean the teeth except function except having ordinary toothpaste; also have anti-to get angry, antianaphylactic effect, effectively can solve the symptom such as gingival swelling and pain, oral ulcer, halitosis caused because getting angry, life-time service can alleviate rapidly hemodia pain; protection oral cavity tissue, maintenance gingiva.
Detailed description of the invention
Be described in more detail below in conjunction with the technical scheme of detailed description of the invention to this patent.
Embodiment 1
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 80 parts, 20 parts, calcite, fulvic acid 8 parts, Chinese medicine extract 2 parts, Herba Saussureae Involueratae extract 1 part, peony root extractive 1 part, Vitamin E acetate 0.5 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 10 parts, Radix Notoginseng, Flos Lonicerae 10 parts, Flos Matricariae chamomillae 10 parts, 8 parts, Radix Glycyrrhizae, Radix Scutellariae 8 parts, Herba Menthae 3 parts, Herba Ajugae 3 parts, Herba Houttuyniae 2 parts, Radix Bupleuri 2 parts, Medulla Junci 1 part, Radix Achyranthis Bidentatae 1 part; Described auxiliary agent is made up of the raw material of following weight portion: calcium hydrogen phosphate 30 parts, glycerol 30 parts, 17 parts, water, lauryl alcohol sulphuric acid acid 1 part, carboxymethyl cellulose 1 part, flavouring agent 0.5 part, sweeting agent 0. part, 0.1 part, ascorbic acid, sodium phytate 0.05 part, aloin 0.05 part, glycyrrhizin 0.1 part, glucoseoxidase 0.1 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 80 mesh sieves were pulverized; Be after the soak with ethanol 2h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3h, filter, filtering residue repeats reflux, extract, 2 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 2 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 120 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 50 order after dry, ethyl acetate crushed material being placed in 14 times of equivalents stirs 5h at 50 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 120 orders, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting glycerol is placed in container, under agitation, adds carboxymethyl cellulose, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 2min, obtain the glue of transparent and homogeneous;
(5) calcium hydrogen phosphate, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add sodium laurylsulfate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 5min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Embodiment 2
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 84.27 parts, 22 parts, calcite, fulvic acid 9 parts, Chinese medicine extract 2.5 parts, Herba Saussureae Involueratae extract 1.5 parts, peony root extractive 1.5 parts, Vitamin E acetate 0.6 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 12 parts, Radix Notoginseng, Flos Lonicerae 12 parts, Flos Matricariae chamomillae 12 parts, 9 parts, Radix Glycyrrhizae, Radix Scutellariae 9 parts, Herba Menthae 3.5 parts, Herba Ajugae 3.5 parts, Herba Houttuyniae 2.5 parts, Radix Bupleuri 2.5 parts, Medulla Junci 1.5 parts, Radix Achyranthis Bidentatae 1.5 parts; Described auxiliary agent is made up of the raw material of following weight portion: silicon dioxide 32 parts, sorbitol 30.5 parts, 17.5 parts, water, Laurel acidic group sodium sarcosinate 1.5 parts, light ethyl cellulose 1.2 parts, flavouring agent 0.8 part, sweeting agent 0.15 part, citric acid 0.12 part, sodium phytate 0.1 part, aloin 0.2 part, glycyrrhizin 0.1 part, glucoseoxidase 0.1 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 85 mesh sieves were pulverized; Be after the soak with ethanol 2.2h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3.2h, filter, filtering residue repeats reflux, extract, 3 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 2.2 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 125 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 55 order after dry, ethyl acetate crushed material being placed in 14.5 times of equivalents stirs 5.2h at 52 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 125 orders, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting sorbitol is placed in container, under agitation, adds light ethyl cellulose, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 2.5min, obtain the glue of transparent and homogeneous;
(5) silicon dioxide, citric acid, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add Laurel acidic group sodium sarcosinate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 5.5min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Embodiment 3
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 89.45 parts, 25 parts, calcite, fulvic acid 10 parts, Chinese medicine extract 3 parts, Herba Saussureae Involueratae extract 2 parts, peony root extractive 2 parts, Vitamin E acetate 0.8 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 15 parts, Radix Notoginseng, Flos Lonicerae 15 parts, Flos Matricariae chamomillae 15 parts, 10 parts, Radix Glycyrrhizae, Radix Scutellariae 10 parts, Herba Menthae 4 parts, Herba Ajugae 4 parts, Herba Houttuyniae 3 parts, Radix Bupleuri 3 parts, Medulla Junci 2 parts, Radix Achyranthis Bidentatae 2 parts; Described auxiliary agent is made up of the raw material of following weight portion: calcium hydrogen phosphate 35 parts, propylene glycol 31 parts, 18 parts, water, sodium laurylsulfate 2 parts, xanthan gum 1.5 parts, flavouring agent 1 part, sweeting agent 0.2 part, 0.15 part, ascorbic acid, sodium phytate 0.2 part, aloin 0.2 part, glycyrrhizin 0.1 part, glucoseoxidase 0.1 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 90 mesh sieves were pulverized; Be after the soak with ethanol 2.5h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3.5h, filter, filtering residue repeats reflux, extract, 2 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 2.5 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 130 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 60 order after dry, ethyl acetate crushed material being placed in 15 times of equivalents stirs 5.5h at 55 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 130 orders, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting propylene glycol is placed in container, under agitation, adds xanthan gum, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 3min, obtain the glue of transparent and homogeneous;
(5) calcium hydrogen phosphate, ascorbic acid, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add sodium laurylsulfate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 6min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Embodiment 4
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 95.73 parts, 28 parts, calcite, fulvic acid 11 parts, Chinese medicine extract 3.5 parts, Herba Saussureae Involueratae extract 2.5 parts, peony root extractive 2.5 parts, Vitamin E acetate 0.9 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 18 parts, Radix Notoginseng, Flos Lonicerae 18 parts, Flos Matricariae chamomillae 18 parts, 11 parts, Radix Glycyrrhizae, Radix Scutellariae 11 parts, Herba Menthae 4.5 parts, Herba Ajugae 4.5 parts, Herba Houttuyniae 3.5 parts, Radix Bupleuri 3.5 parts, Medulla Junci 2.5 parts, Radix Achyranthis Bidentatae 2.5 parts; Described auxiliary agent is made up of the raw material of following weight portion: silicon dioxide 38 parts, glycerol 32.5 parts, 18.5 parts, water, Laurel acidic group sodium sarcosinate 2.5 parts, carrageenan 1.8 parts, flavouring agent 1.2 parts, sweeting agent 0.25 part, citric acid 0.18 part, sodium phytate 0.2 part, aloin 0.2 part, glycyrrhizin 0.2 part, glucoseoxidase 0.2 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 95 mesh sieves were pulverized; Be after the soak with ethanol 2.8h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3.8h, filter, filtering residue repeats reflux, extract, 3 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 2.8 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 135 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 65 order after dry, ethyl acetate crushed material being placed in 15.5 times of equivalents stirs 5.8h at 58 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 135, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting glycerol is placed in container, under agitation, adds carrageenan, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 3.5min, obtain the glue of transparent and homogeneous;
(5) silicon dioxide, citric acid, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add Laurel acidic group sodium sarcosinate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 6.5min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Embodiment 5
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 100 parts, 30 parts, calcite, fulvic acid 12 parts, Chinese medicine extract 4 parts, Herba Saussureae Involueratae extract 3 parts, peony root extractive 3 parts, Vitamin E acetate 1 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 20 parts, Radix Notoginseng, Flos Lonicerae 20 parts, Flos Matricariae chamomillae 20 parts, 12 parts, Radix Glycyrrhizae, Radix Scutellariae 12 parts, Herba Menthae 5 parts, Herba Ajugae 5 parts, Herba Houttuyniae 4 parts, Radix Bupleuri 4 parts, Medulla Junci 3 parts, Radix Achyranthis Bidentatae 3 parts; Described auxiliary agent is made up of the raw material of following weight portion: calcium hydrogen phosphate 40 parts, sorbitol 33 parts, 19 parts, water, sodium laurylsulfate 3 parts, carboxymethyl cellulose 2 parts, flavouring agent 1.5 parts, sweeting agent 0.3 part, 0.2 part, ascorbic acid, sodium phytate 0.2 part, aloin 0.2 part, glycyrrhizin 0.3 part, glucoseoxidase 0.3 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 100 mesh sieves were pulverized; Be after the soak with ethanol 3h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 4h, filter, filtering residue repeats reflux, extract, 2 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 3 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 140 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 70 order after dry, ethyl acetate crushed material being placed in 16 times of equivalents stirs 6h at 60 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 140 orders, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting sorbitol is placed in container, under agitation, adds carboxymethyl cellulose, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 4min, obtain the glue of transparent and homogeneous;
(5) calcium hydrogen phosphate, ascorbic acid, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add sodium laurylsulfate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 7min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Comparative example 1
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 84.27 parts, 22 parts, calcite, fulvic acid 9 parts, Chinese medicine extract 2.5 parts, peony root extractive 1.5 parts, Vitamin E acetate 0.6 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 12 parts, Radix Notoginseng, Flos Lonicerae 12 parts, Flos Matricariae chamomillae 12 parts, 9 parts, Radix Glycyrrhizae, Radix Scutellariae 9 parts, Herba Menthae 3.5 parts, Herba Ajugae 3.5 parts, Herba Houttuyniae 2.5 parts, Radix Bupleuri 2.5 parts, Medulla Junci 1.5 parts, Radix Achyranthis Bidentatae 1.5 parts; Described auxiliary agent is made up of the raw material of following weight portion: silicon dioxide 32 parts, sorbitol 30.5 parts, 17.5 parts, water, Laurel acidic group sodium sarcosinate 1.5 parts, light ethyl cellulose 1.2 parts, flavouring agent 0.8 part, sweeting agent 0.15 part, citric acid 0.12 part, sodium phytate 0.1 part, aloin 0.2 part, glycyrrhizin 0.1 part, glucoseoxidase 0.1 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 85 mesh sieves were pulverized; Be after the soak with ethanol 2.2h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3.2h, filter, filtering residue repeats reflux, extract, 3 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 2.2 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 125 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 55 order after dry, ethyl acetate crushed material being placed in 14.5 times of equivalents stirs 5.2h at 52 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 125 orders, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting sorbitol is placed in container, under agitation, adds light ethyl cellulose, makes to be uniformly dispersed; Again Chinese medicine extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 2.5min, obtain the glue of transparent and homogeneous;
(5) silicon dioxide, citric acid, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add Laurel acidic group sodium sarcosinate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 5.5min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Comparative example 2
A health-care toothpaste containing Chinese herbal medicine, is made up of the following raw material according to weight portion: auxiliary agent 95.73 parts, 28 parts, calcite, fulvic acid 11 parts, Chinese medicine extract 3.5 parts, Herba Saussureae Involueratae extract 2.5 parts, Vitamin E acetate 0.9 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 18 parts, Radix Notoginseng, Flos Lonicerae 18 parts, Flos Matricariae chamomillae 18 parts, 11 parts, Radix Glycyrrhizae, Radix Scutellariae 11 parts, Herba Menthae 4.5 parts, Herba Ajugae 4.5 parts, Herba Houttuyniae 3.5 parts, Radix Bupleuri 3.5 parts, Medulla Junci 2.5 parts, Radix Achyranthis Bidentatae 2.5 parts; Described auxiliary agent is made up of the raw material of following weight portion: silicon dioxide 38 parts, glycerol 32.5 parts, 18.5 parts, water, Laurel acidic group sodium sarcosinate 2.5 parts, carrageenan 1.8 parts, flavouring agent 1.2 parts, sweeting agent 0.25 part, citric acid 0.18 part, sodium phytate 0.2 part, aloin 0.2 part, glycyrrhizin 0.2 part, glucoseoxidase 0.2 part.
The preparation method of the described health-care toothpaste containing Chinese herbal medicine, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 95 mesh sieves were pulverized; Be after the soak with ethanol 2.8h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3.8h, filter, filtering residue repeats reflux, extract, 3 times, merge ethanol extraction filtrates, wherein the addition of ethanol is 2.8 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 135 mesh sieves, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, co-grinding to 65 order after dry, ethyl acetate crushed material being placed in 15.5 times of equivalents stirs 5.8h at 58 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 135, obtains Chinese medicine extraction powder B for subsequent use;
(4) getting glycerol is placed in container, under agitation, adds carrageenan, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 3.5min, obtain the glue of transparent and homogeneous;
(5) silicon dioxide, citric acid, sodium phytate, aloin, glycyrrhizin and glucoseoxidase are added in the glue of above-mentioned storage, first slowly stir, after all disperseing, improve rotating speed, till uniformly body of paste, add Laurel acidic group sodium sarcosinate, flavouring agent and sweeting agent again, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 6.5min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
Embodiment 6
Clinical trial
(1) subjects: adopt the present invention to carry out clinical oral test to 200 routine patients, this 200 routine patient all suffers from recurrent exerbation oral ulcer, and is attended by the symptom of gingival swelling and pain and gingival hemorrhage, wherein man 120 example, female 80 example; The oldest person 64 years old, age reckling 12 years old;
(2) Therapeutic Method: by man 120 example, the routine patient of female 80 is equally divided into five groups, often group man 24 example, female 16 example, one group, two groups and three groups are test group, the health-care toothpaste of the present invention that a group, two groups and three components do not use embodiment 1-embodiment 3 to prepare, and four groups and five groups is matched group, take comparative example 1 respectively and comparative example 2 prepares toothpaste for four groups and five groups, usage: every day, toothpaste was brushed teeth 2 times, each 5min 3 months is a course for the treatment of.After the course for the treatment of of continuous use, add up the therapeutic outcome of five groups, observe the untoward reaction that treatments period patient occurs simultaneously.
(3) standard is treated:
Cure: change highly significant is that total ulcer number obviously reduces, gingival swelling and pain and gingival hemorrhage transference cure;
Effective: total ulcer decreased number, the symptom such as gingival swelling and pain and gingival hemorrhage alleviates or the cycle stretch-out that shows effect;
Invalid: total ulcer number is unchanged, and the symptom such as gingival swelling and pain and gingival hemorrhage is without alleviating.
(4) therapeutic outcome: how to take effect after 20 days after taking medicine in the routine case of patient 200,1-2 the course for the treatment of cures; Wherein cure 98 examples, effective 75 examples, invalid 27 examples, total effective rate reaches 86.5%, and therapeutic outcome is as shown in table 1:
Table 1: clinical trial therapeutic outcome
As shown in Table 1, the average effectiveness level that the health-care toothpaste adopting the present invention to prepare carries out treating reaches 96.6%, and the effective percentage adopting comparative example to prepare health-care toothpaste only has 71.3%, therefore, between ointment raw material of the present invention, there is synergistic function, add the effective percentage of toothpaste.
Embodiment 7
Health-care toothpaste prepared by the present invention is to chronic gingivitis efficacy experiment
1. test objective: health-care toothpaste prepared by observation the present invention is to the clinical effectiveness of chronic gingivitis.
2. EXPERIMENTAL DESIGN:
(1) chronic gingivitis patient is selected
Inclusive criteria: whole body health in order, without important whole body system disease, have more than 20 detectable teeth; Age is in 18 one full year of life one full year of life-70; If be women, must not be in trimester of pregnancy and age of sucking; Experimenter has bacterial plaque or the gingivitis of suitable degree; Do not participate in other similar experimental studies simultaneously; Patient can complete clinical trial on request.
Exclusion standard: have allergies to test toothpaste component; Take now the influential medicine of result of the test; Antibiotic is used in the previous moon participating in research; Open dental caries is had in oral cavity; Suffer from serious periodontitis.
(2) test grouping: experimenter is divided into test group (using the health-care toothpaste that embodiment 3 prepares) and matched group (using idle effective toothpaste) by table of random number; Matched group and the condition close (p > 0.05) of test group in age, sex, bacterial plaque and gingivitis degree etc.
(3) clinical trial adopts mono blind method to test: it is product to be measured or reference product that experimenter does not understand it used.Observation index:
1) gingival hemorrhage index (SBI): the index of reflection gingivitis, the gingival hemorrhage order of severity.
2) plaque index (Q-H): record dental plaque area coverage, thickness.
(4) test method:
1) before toothpaste uses, patient's gingiva situation is checked, record SBI and PI.
2) use of toothpaste: provide toothpaste to patient, advises patient to brush teeth with this product every day, and every day respectively once, uses about 3g sooner or later at every turn, and perpendicular brush method is brushed teeth, medium dynamics, 3min.
3) reduce the test of dental plaque, need before the test first to carry out scaling to experimenter, removing tartar, same day on-test removes bacterial plaque, soft dirt with rubber polishing cup, then brings into use product.Respectively in the change of the 7th day and 14 days assessment bacterial plaque amounts.
4) alleviate the test of gingivitis, carry out twice clinical examination (review time be respectively test the 7th day and 14 days).
(5) statistical analysis:
Test group 13 example, matched group 15 example, measurement data mean scholar standard deviation (x ± s) represents, uses SPSS13.0 software to add up, difference employing one factor analysis of variance between group and in group.
(6) result of the test:
28 routine experimenters check all on time, male 16 example, women 12 example, 22 ± 2.17 years old mean age.In process of the test, there is not relevant adverse events in patient.For the anastalsis of testing experiment group toothpaste, we select gingival hemorrhage index (SBI) this observation index, compare with matched group with before treating.The display of current result, after two groups of treatments, after 1 week and treatment, the gingival hemorrhage exponential sum plaque index of 2 weeks is all remarkable in before treating; Result is as shown in table 2:
Table 2 health-care toothpaste of the present invention is on the impact (x ± s) of gingivitis patients SBI exponential sum Q-H index
* P < 0.05 is compared with before treatment.
(7) conclusion:
From current result of the test visual data, test group toothpaste is to the better efficacy of the curative effect of chronic gingivitis compared with matched group toothpaste; As can be seen from clinography, within first week, weigh after the hemorrhage comparatively treatment of second week after the case treatment that matched group toothpaste has, namely have rebound phenomena, and As time goes on experimental group toothpaste be generally, gingival hemorrhage phenomenon alleviates gradually.
Embodiment 8
Health-care toothpaste prepared by the present invention is to the clinical observation on the therapeutic effect of oral ulcer
1. test objective: health-care toothpaste prepared by observation the present invention is to the clinical efficacy of oral ulcer.
2. EXPERIMENTAL DESIGN:
(1) crowd's inclusive criteria is tested:
Experimenter has the symptom of oral ulcer, comprises sporadic oral ulcer and all kinds of recurrent oral ulceration (comprising light-duty MiRAU, heavy MaRAU and scar rash sample ulcer HU); Age is in 6 one full year of life one full year of life-75; If be women, must not be in trimester of pregnancy and age of sucking; Clearly can express the effect before and after using; Do not participate in other similar experimental studies simultaneously; Patient can complete clinical trial on request.
(2) test grouping: experimenter is divided into test group (using the health-care toothpaste that embodiment 3 prepares) and matched group (using idle effective toothpaste), often group is no less than 10 people.Matched group and the condition close (p>0.05) of test group in age, sex, oral ulcer degree etc.Clinical trial adopts mono blind method to test: it is product to be measured or reference product that experimenter does not understand it used.
(3) observation index: canker sores degree and healing.
(4) test method: provide toothpaste to patient, advises patient to brush teeth with this product every day, and every day respectively once, uses about 3g sooner or later at every turn, and perpendicular brush method is brushed teeth, and medium dynamics, 3min, by collutory more than rinsing the mouth 5s in mouth when gargling.
(5) statistical analysis: amount data mean scholar standard deviation (x ± s) represents, uses SPSS13.0 software to add up, difference employing one factor analysis of variance between group and in group.
3, result of the test: tested crowd is totally 57 people, minimum 8 years old, maximum 75 years old, 38.7 years old mean age; Male 18 people, women 39 people; Matched group 15 example, test group 42 example, test group is comprising sporadic ulcer 13 example, and recurrent ulcer 29 is routine.Once, consulting uses the canker sores degree after toothpaste and healing to 57 routine experimenters every two days call-on back by phones.
(1) canker sores alleviates situation: (pain degree score is 0-10 grade, and 0 indicates without pain, and 5 represent moderate pain, and 10 represent top pain, and other are analogized)
Report situations from experimenter, toothpaste is used within ulcer is shown effect 3 days, the pain degree of this health-care toothpaste ulcer is used to alleviate obvious effective rate 75% (using pain after 1 day obviously to alleviate), total effective rate 92% (using pain after 3 days obviously to alleviate); And matched group uses front and back zero difference.
Pain degree according to using natural law different is evaluated as shown in table 3:
Table 3: oral ulcer patient is to canker sores degree evaluation table after use toothpaste
Remarks: compared with before use, variant: * P < 0.05.
Result illustrates: the canker sores degree of test group alleviates gradually along with using the increase of natural law, compared with before use, uses after 1 day and namely occurs difference, and matched group uses front and back contrast zero difference.
(2) ulcer surface healing time: (disappear completely with ulcer surface in patient oral cavity and be as the criterion), healing time is as shown in table 4:
Table 4: after using toothpaste of the present invention, the ulcer surface healing time (natural law) of oral cavity ulcers compares
| Matched group | Test group | |
| Ulcer uses within showing effect 3 days | 5.18±0.62 | 4.03±0.93* |
| Ulcer is shown effect more than 3 days and is used | 5.42±1.31 | 3.84±1.24 |
Remarks: compared with matched group, variant: * P < 0.05.
Result illustrates: in healing, data compare discovery, use the test group of this effect toothpaste obviously to shorten than the ulcer surface healing time of matched group within showing effect 3 days for ulcer, but for ulcer oneself through showing effect more than 3 days, matched group and test group zero difference.
4. conclusion (of pressure testing):
Oral ulcer eats membrane disease as a kind of oral cavity, makes patient's causalgia unbearably, causes being not suitable with on the daily life such as patients diet.Can determine from the above results, containing effect toothpaste of somatomedin can effectively alleviate ulcer show effect 3 days within the pain degree of ulcer, can healing be shortened, but for ulcer show effect more than 3 days there is no remarkable result.Because most subjects exists recurrent oral ulceration situation, relevant with experimenter's individual physique, see on the whole, this effect toothpaste can be alleviated the oral cavity pain of local and promote ulcer healing, but can not the generation of preventing canker sore.
In the present invention, each raw material synergism plays the effect with Qinghuo Jiedu, clearing away heat-damp and promoting diuresis, anti-inflammatory analgesic; preparation technology is simple, environmentally friendly; there is no toxic and side effects; clean the teeth except function except having ordinary toothpaste; also have anti-to get angry, antianaphylactic effect, effectively can solve the symptom such as gingival swelling and pain, oral ulcer, halitosis caused because getting angry, life-time service can alleviate rapidly hemodia pain; protection oral cavity tissue, maintenance gingiva.
Above the better embodiment of this patent is explained in detail, but this patent is not limited to above-mentioned embodiment, in the ken that one skilled in the relevant art possesses, various change can also be made under the prerequisite not departing from this patent aim.
Claims (10)
1. the health-care toothpaste containing Chinese herbal medicine, it is characterized in that, be made up of the following raw material according to weight portion: auxiliary agent 80-100 part, calcite 20-30 part, fulvic acid 8-12 part, Chinese medicine extract 2-4 part, Herba Saussureae Involueratae extract 1-3 part, peony root extractive 1-3 part, Vitamin E acetate 0.5-1 part; Described Chinese medicine extract is made up of the raw material of following weight portion: Radix Notoginseng 10-20 part, Flos Lonicerae 10-20 part, Flos Matricariae chamomillae 10-20 part, Radix Glycyrrhizae 8-12 part, Radix Scutellariae 8-12 part, Herba Menthae 3-5 part, Herba Ajugae 3-5 part, Herba Houttuyniae 2-4 part, Radix Bupleuri 2-4 part, Medulla Junci 1-3 part, Radix Achyranthis Bidentatae 1-3 part; Described auxiliary agent is made up of the raw material of following weight portion: abrasivus 30-40 part, wetting agent 30-33 part, water 17-19 part, foaming agent 1-3 part, binding agent 1-2 part, flavouring agent 0.5-1.5 part, sweeting agent 0.1-0.3 part, stabilizing agent 0.1-0.2 part, whitening agent 0.3-1 part.
2. the health-care toothpaste containing Chinese herbal medicine according to claim 1, it is characterized in that, be made up of the following raw material according to weight portion: auxiliary agent 84.27-95.73 part, calcite 22-28 part, fulvic acid 9-11 part, Chinese medicine extract 2.5-3.5 part, Herba Saussureae Involueratae extract 1.5-2.5 part, peony root extractive 1.5-2.5 part, Vitamin E acetate 0.6-0.9 part; Described Chinese medicine extract is made up of the raw material of following weight portion: Radix Notoginseng 12-18 part, Flos Lonicerae 12-18 part, Flos Matricariae chamomillae 12-18 part, Radix Glycyrrhizae 9-11 part, Radix Scutellariae 9-11 part, Herba Menthae 3.5-4.5 part, Herba Ajugae 3.5-4.5 part, Herba Houttuyniae 2.5-3.5 part, Radix Bupleuri 2.5-3.5 part, Medulla Junci 1.5-2.5 part, Radix Achyranthis Bidentatae 1.5-2.5 part; Described auxiliary agent is made up of the raw material of following weight portion: abrasivus 32-38 part, wetting agent 30.5-32.5 part, water 17.5-18.5 part, foaming agent 1.5-2.5 part, binding agent 1.2-1.8 part, flavouring agent 0.8-1.2 part, sweeting agent 0.15-0.25 part, stabilizing agent 0.12-0.18 part, whitening agent 0.5-0.8 part.
3. according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, be made up of the following raw material according to weight portion: auxiliary agent 89.45 parts, 25 parts, calcite, fulvic acid 10 parts, Chinese medicine extract 3 parts, Herba Saussureae Involueratae extract 2 parts, peony root extractive 2 parts, Vitamin E acetate 0.8 part; Described Chinese medicine extract is made up of the raw material of following weight portion: 15 parts, Radix Notoginseng, Flos Lonicerae 15 parts, Flos Matricariae chamomillae 15 parts, 10 parts, Radix Glycyrrhizae, Radix Scutellariae 10 parts, Herba Menthae 4 parts, Herba Ajugae 4 parts, Herba Houttuyniae 3 parts, Radix Bupleuri 3 parts, Medulla Junci 2 parts, Radix Achyranthis Bidentatae 2 parts; Described auxiliary agent is made up of the raw material of following weight portion: abrasivus 35 parts, wetting agent 31 parts, 18 parts, water, foaming agent 2 parts, binding agent 1.5 parts, flavouring agent 1 part, sweeting agent 0.2 part, stabilizing agent 0.15 part, whitening agent 0.6 part.
4. according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, described wetting agent is one or more in glycerol, sorbitol, propylene glycol.
5. according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, described binding agent is one or more in carboxymethyl cellulose, light ethyl cellulose, xanthan gum, carrageenan.
6., according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, described foaming agent is sodium laurylsulfate or Laurel acidic group sodium sarcosinate.
7., according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, described abrasivus is calcium hydrogen phosphate or silicon dioxide.
8., according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, described stabilizing agent is ascorbic acid or citric acid.
9., according to the arbitrary described health-care toothpaste containing Chinese herbal medicine of claim 1-2, it is characterized in that, described whitening agent comprises sodium phytate, aloin, glycyrrhizin and glucoseoxidase.
10. a preparation method for the health-care toothpaste containing Chinese herbal medicine as described in as arbitrary in claim 1-2, it is characterized in that, concrete steps are as follows:
(1) each raw material is taken according to weight portion;
(2), after Radix Notoginseng, Flos Lonicerae, Flos Matricariae chamomillae, Radix Glycyrrhizae, Radix Scutellariae and Herba Menthae being used clear water cleaning, drying respectively, 80-100 mesh sieve was pulverized; Be after the soak with ethanol 2-3h of 75% respectively with mass percent concentration by Radix Notoginseng powder, Flos Lonicerae powder, Flos Matricariae chamomillae powder, Radix Glycyrrhizae powder, Radix Scutellariae powder and Herba Menthae powder, reflux, extract, 3-4h, filter, filtering residue repeats reflux, extract, 2-3 time, merge ethanol extraction filtrates, wherein the addition of ethanol is 2-3 times of raw material powder quality; Ethanol extraction filtrates is solid through concentrate drying, obtains Chinese medicine extract A, is pulverized by Chinese medicine extract A, crosses 120-140 mesh sieve, obtains Chinese medicine extract powder A for subsequent use;
(3) by Herba Ajugae, Herba Houttuyniae, Radix Bupleuri, Medulla Junci and Radix Achyranthis Bidentatae remove impurity cleaning, after dry, co-grinding is to 50-70 order, ethyl acetate crushed material being placed in 14-16 times of equivalent stirs 5-6h at 50-60 DEG C, rear leaching filtrate excessively, through distilling under reduced pressure removing ethyl acetate, gained solid powder is broken to 120-140 order, obtains Chinese medicine extraction powder B for subsequent use;
(4) humectant of going bail for is placed in container, under agitation, adds binding agent, makes to be uniformly dispersed; Again Chinese medicine extract, Herba Saussureae Involueratae extract, peony root extractive and Vitamin E acetate are dissolved in water, under agitation, slowly add, stir 2-4min, obtain the glue of transparent and homogeneous;
(5) abrasivus, stabilizing agent and whitening agent are added in the glue of above-mentioned storage, first slowly stir, after whole dispersions, improve rotating speed, till uniformly body of paste, then add foaming agent, flavouring agent and sweeting agent, stir evenly;
(6) calcite and fulvic acid are added in above-mentioned mastic, stir evenly; Again mastic is added in vacuum emulsifying machine, first homogenizing 5-7min, then carry out degassed process, until bubble is all deviate from mastic, become the finished product that light is fine and smooth;
(7) poured into by finished product and aluminize in flexible pipe, end-blocking, to obtain final product.
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| CN109152722A (en) * | 2016-05-30 | 2019-01-04 | 狮王株式会社 | Composition for oral cavity |
| CN109498524A (en) * | 2018-12-30 | 2019-03-22 | 广东新南方青蒿日化有限公司 | A kind of Chinese medicine compound prescription sweet wormwood toothpaste and preparation method thereof |
| CN114432222A (en) * | 2022-01-24 | 2022-05-06 | 西安拜尔海森生物制药有限公司 | Aqueous solution for oral care and preparation method thereof |
| CN116059143A (en) * | 2022-12-28 | 2023-05-05 | 广西壮族自治区药用植物园 | A kind of Yaoyao Xuedan toothpaste and its preparation method |
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| CN116059143A (en) * | 2022-12-28 | 2023-05-05 | 广西壮族自治区药用植物园 | A kind of Yaoyao Xuedan toothpaste and its preparation method |
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Application publication date: 20160323 |