CN105411873A - Application of antibacterial peptide as anti-inflammation acne removal agent for cosmetic preparation - Google Patents
Application of antibacterial peptide as anti-inflammation acne removal agent for cosmetic preparation Download PDFInfo
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- CN105411873A CN105411873A CN201510919320.1A CN201510919320A CN105411873A CN 105411873 A CN105411873 A CN 105411873A CN 201510919320 A CN201510919320 A CN 201510919320A CN 105411873 A CN105411873 A CN 105411873A
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- 206010000496 acne Diseases 0.000 title claims abstract description 35
- 239000003910 polypeptide antibiotic agent Substances 0.000 title claims abstract description 35
- 239000002537 cosmetic Substances 0.000 title claims abstract description 26
- 208000002874 Acne Vulgaris Diseases 0.000 title claims abstract description 20
- 239000003795 chemical substances by application Substances 0.000 title claims abstract description 8
- 238000002360 preparation method Methods 0.000 title claims abstract description 7
- 206010061218 Inflammation Diseases 0.000 title abstract description 6
- 108050004290 Cecropin Proteins 0.000 claims abstract description 4
- 239000000287 crude extract Substances 0.000 claims abstract description 4
- 239000000284 extract Substances 0.000 claims abstract description 4
- 230000003110 anti-inflammatory effect Effects 0.000 claims description 9
- 239000006071 cream Substances 0.000 claims description 7
- 239000007788 liquid Substances 0.000 claims description 6
- 239000000843 powder Substances 0.000 claims description 3
- 239000000839 emulsion Substances 0.000 claims description 2
- 235000015110 jellies Nutrition 0.000 claims description 2
- 239000008274 jelly Substances 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 10
- 241000191967 Staphylococcus aureus Species 0.000 abstract description 8
- 241000186427 Cutibacterium acnes Species 0.000 abstract description 7
- 229940055019 propionibacterium acne Drugs 0.000 abstract description 7
- 241000191963 Staphylococcus epidermidis Species 0.000 abstract description 3
- 230000002147 killing effect Effects 0.000 abstract description 3
- 230000028327 secretion Effects 0.000 abstract description 3
- 125000000539 amino acid group Chemical group 0.000 abstract description 2
- 210000002374 sebum Anatomy 0.000 abstract description 2
- 230000000638 stimulation Effects 0.000 abstract description 2
- 208000020154 Acnes Diseases 0.000 abstract 1
- 230000003467 diminishing effect Effects 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 239000002994 raw material Substances 0.000 abstract 1
- 230000008961 swelling Effects 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 15
- 210000003491 skin Anatomy 0.000 description 13
- 238000003756 stirring Methods 0.000 description 6
- 230000001139 anti-pruritic effect Effects 0.000 description 5
- 239000003908 antipruritic agent Substances 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 206010037888 Rash pustular Diseases 0.000 description 4
- 230000003255 anti-acne Effects 0.000 description 4
- 238000000034 method Methods 0.000 description 4
- 238000007639 printing Methods 0.000 description 4
- 208000029561 pustule Diseases 0.000 description 4
- 238000007599 discharging Methods 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 206010011732 Cyst Diseases 0.000 description 2
- 241000700647 Variola virus Species 0.000 description 2
- 230000036760 body temperature Effects 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 208000031513 cyst Diseases 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 230000001804 emulsifying effect Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 238000000265 homogenisation Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 230000002940 repellent Effects 0.000 description 2
- 239000005871 repellent Substances 0.000 description 2
- 210000001732 sebaceous gland Anatomy 0.000 description 2
- 230000001629 suppression Effects 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010020649 Hyperkeratosis Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 206010039792 Seborrhoea Diseases 0.000 description 1
- 208000033809 Suppuration Diseases 0.000 description 1
- 208000031320 Teratogenesis Diseases 0.000 description 1
- 206010000269 abscess Diseases 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000000051 antiandrogen Substances 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 230000033228 biological regulation Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000004945 emulsification Methods 0.000 description 1
- 230000002124 endocrine Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 239000003925 fat Substances 0.000 description 1
- 238000000855 fermentation Methods 0.000 description 1
- 230000004151 fermentation Effects 0.000 description 1
- 230000003325 follicular Effects 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 210000003780 hair follicle Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 230000003907 kidney function Effects 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 235000014593 oils and fats Nutrition 0.000 description 1
- 230000037312 oily skin Effects 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 210000004378 sebocyte Anatomy 0.000 description 1
- 208000017520 skin disease Diseases 0.000 description 1
- 210000003859 smegma Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/74—Biological properties of particular ingredients
- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
- A61K2800/782—Enzyme inhibitors; Enzyme antagonists
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Cosmetics (AREA)
Abstract
The invention relates to application of an antibacterial peptide as an anti-inflammation acne removal agent for cosmetic preparation. The antibacterial peptide is a crude extract or refined extract of the cecropin. The antibacterial peptide contains 37-39 amino acid residues and has the advantages that 1, 0.01-50% of the antibacterial peptide is added into cosmetics, and the antibacterial peptide has the effects of adjusting skin sebum secretion, diminishing inflammation and removing swelling, has the good inhibition and killing effects on propionibacterium acnes, staphylococcus epidermidis and staphylococcus aureus, can effectively prevent and remove acnes, pimples and whelks and enables the skin to be full of vitality and vigor; the application range of the antibacterial peptide is wide, the antibacterial peptide can be well matched with a large number of cosmetic raw materials, and addition is easy and convenient; the product is safe, reliable and free of stimulation.
Description
Technical field
The invention belongs to cosmetic technical field, relate to a kind of antibacterial peptide as the application of antiinflammatory acne removing agent in cosmetics preparation.
Background technology
Pox is being commonly called as of acne, also known as " comedo ", " skin sore " or " acne ", is a kind of by multifactor common chronic hair follicle, the sebaceous gland inflammatory dermatoses that cause, is mainly in the position that the sebaceous gland such as face, cervical region, shirtfront back are abundant.According to statistics, about have the people of 85% to suffer from acne in various degree in adolescence, the patient of 14 ~ 19 years old accounts for 20.1% of total number of the infected, within 20 ~ 24 years old, accounts for 43.0%, within 25 ~ 29 years old, accounts for 13.6%, within 30 ~ 39 years old, account for 13.6%, within 40 ~ 45 years old, account for 1.9%.Its cause of disease is except with endocrine, immunity, smegma too much and outside the Pass the factor such as follicular hyperkeratosis has, also closely related with the mixed infection of propionibacterium acnes and the bacterium such as staphylococcus epidermidis, staphylococcus aureus.Doctor trained in Western medicine mainly uses these diseases for the treatment of such as androgen antagonist, antibiotic, tretinoin medicines, and curative effect is determined, but toxic and side effects is obvious, as hepatic and renal function injure, teratogenesis etc.Compared with medicine, the security requirement of cosmetics is higher, not only requires use safety, and can not produce obvious stimulation and damage to site of administration, more can not produce any Drug resistance.Therefore safely, the natural component of comedo can be effectively suppressed will to become the focus of anti-acne class cosmetic industry composition exploitation.
Summary of the invention
The present invention studies the cecropin antimicrobial peptides finding to derive from fermentation of bacillus product has good suppression, killing action to causing the propionibacterium acnes of comedo, staphylococcus epidermidis and staphylococcus aureus; adjustable skin microecological balance; one natural protective barrier is formed at skin surface; protection skin is from the infringement of the harmful substances such as antibacterial; strengthen skin immunization power; antiinflammatory is dispelled swollen; controls local infects; and can effectively suppress sebocyte cell to produce oils and fats, the effects such as horny layer softening.The object of the invention is in conjunction with conventional art and emerging biotechnology, antibacterial peptide is applied in traditional cosmetics preparation, solves the new way of acne-removing inflammation-diminishing for cosmetics developer provides a kind of or provide one to select widely.
For achieving the above object, the technology used in the present invention side is as follows:
The invention provides a kind of antibacterial peptide as the application of antiinflammatory acne removing agent in cosmetics preparation, it is characterized in that, described antibacterial peptide is extract or the crude extract of cecropin antimicrobial peptides.
Described antibacterial peptide, is characterized in that, described antibacterial peptide adopts liquid or powder.
Described application, is characterized in that, the cosmetics scope that is suitable for for but be not limited to: liquid type, emulsion class, cream kind, jelly class.
Described application, is characterized in that, the use amount of described antibacterial peptide in cosmetics is 0.01 ~ 50% of this cosmetics gross weight.
Described application, is characterized in that, adds in cosmetics when described antibacterial peptide is below 50 DEG C.
Antibacterial peptide involved in the present invention contains 37 ~ 39 amino acid residues, has following beneficial effect:
1) extract of antibacterial peptide of the present invention or crude extract add in cosmetics with the dosage of addition 0.01% ~ 50%, there is regulation of skin sebum secretion, antiinflammatory is dispelled swollen, and to causing the propionibacterium acnes of comedo, epidermis staphylococcus aureus and staphylococcus aureus to have good suppression, killing action, effectively can prevent and removing acne, skin sore, acne, make skin full of vitality.
2) antibacterial peptide applied range of the present invention, can be good with most of cosmetic material compatibility; Can be applicable to, in each large dosage form of cosmetics, add simple and convenient.
3) this product safety is reliable, non-stimulated.
Detailed description of the invention
Below embodiments of the invention are described in further detail:
Embodiment 1
Embodiment 1 is that antibacterial peptide is as the application of acne-removing inflammation-diminishing agent in Deacne pack.
Table 1 Deacne pack formula
In table 1, each formula is prepared by following technique respectively:
1.A phase is mixed and heated to 80 ~ 85 DEG C and dissolves completely, and constant temperature stirs 15min;
2.A phase low rate mixing is cooled to 50 DEG C, adds B, C phase component, and stirs;
3. when temperature is down to 35 DEG C, discharging.
Embodiment 2
Embodiment 2 is that antibacterial peptide is as the application of acne-removing inflammation-diminishing agent in emulsification system (acne eliminating cream and anti-acne elite).
Table 2 acne eliminating cream formula
In table 2, each formula is prepared by following technique respectively:
1.A phase is mixed and heated to 90 ~ 95 DEG C and dissolves completely, and constant temperature stirs 15min; B phase component is mixed and heated to 80 ~ 85 DEG C and dissolves completely;
2. A is added in B phase, after high speed homogenization emulsifying 5min, at 80 ~ 85 DEG C of insulated and stirred 30min.
3. add C, D phase component when emulsified body temperature is down to 45 DEG C, after dispersed with stirring is even.
4. when temperature is down to 35 DEG C, discharging.
A table 3 pox essence formula
In table 3, each formula is prepared by following technique respectively:
1.A phase is mixed and heated to 85 ~ 90 DEG C and dissolves completely, and constant temperature stirs 15min; B phase component is mixed and heated to 80 ~ 85 DEG C and dissolves completely;
2. A is added in B phase, after high speed homogenization emulsifying 5min, at 80 ~ 85 DEG C of insulated and stirred 30min.
3. add C, D phase component when emulsified body temperature is down to 45 DEG C, after dispersed with stirring is even.
4. when temperature is down to 35 DEG C, discharging.
Below by way of concrete test example, the purposes of antibacterial peptide at cosmetics is described
Test example 1
This test example have studied the extracorporeal bacteria inhibitor test of antibacterial peptide.
The antibacterial peptide liquid adding 3.0% enters in cosmetics, and inoculates propionibacterium acnes or staphylococcus aureus, makes the concentration of bacterium in product reach 1 × 10
6cFU/g, sampling in every 7 days, adopt clump count in colony counting method testing product, result is as shown in table 3.As can be seen here, after 7 days, the total bacterium of propionibacterium acnes and staphylococcus aureus can maintain below 100CFU/g, proves that antibacterial peptide effectively can suppress the growth of propionibacterium acnes and staphylococcus aureus thus.
Table 3 bacteriostatic test result
Test example 2
This test example have studied the effect for the acne eliminating cream prepared by the embodiment of the present invention 2.
The acne eliminating cream product of embodiment 2 is carried out human experimentation, test number is 30 people, skin characteristic is oily skin, slight and moderate comedo skin, test period is 28 days, tester is divided into 3 groups, often organizes 10 people, use each formulation product in embodiment 2 respectively, use test products after clean of tester every day, sooner or later each once.The use senses such as assessment tester anti-acne antiinflammatory situation, the glossy minimizing of skin are subject to.Test result is as shown in table 4.
Table 4 test result
From table 4, no matter use is after adding antibacterial peptide powder or the acne eliminating cream of liquid, and the minimizing degree that the eradicating efficacy of small pox, skin are glossy and the effect that antiinflammatory is releived all significantly are better than the frost using comparative formula (basic components); As can be seen here, antibacterial peptide has significant anti-acne effect, and can reduce skin oil and fat secretion, and antiinflammatory is anti-swollen, the effect of pain of releiving.
Test 3
This test example have studied the clinical practice for the some pox elite prepared by the embodiment of the present invention 2.
Adopt the some pox elite random selecting prepared by the embodiment of the present invention 2 to suffer from the patient of comedo, usage and consumption: after clean face, to dip elite be applied in affected part with medicinal cotton swab, massage is until absorb gently, and every day uses 3-4 time.
(1) Zhao so-and-so: female, 32 years old, facial comedo quantity was less than 20, and volume is little, red and swollen, itch, and use some pox elite (formula 1) 3 ~ 4h afterwards, antipruritic, redness is decorporated, and after 2 days, small pox disappears.
(2) Qiu so-and-so: female, 16 years old, comedo volume is large, quantity is many (more than 20, be less than 100), top easily occurs that pus point forms abscess, touching pain, after using some pox elite (formula 2) 6h redness disappear, antipruritic, after using 6 days after going pustule, comedo disappears.
(3) Lee so-and-so: man 23 years old, there is white blackhead in face, red and swollen, and after lifting one's head, spot printing point pox elite (formula 1) 4 ~ 5h redness disappears, and 5 Tian Hou faces acne disappear.
(4) easily so-and-so: man 25 years old, face's comedo quantity is many, and volume is large, forms pustule, have sense of acutely touching a tender spot, spot printing point pox elite after 2 days redness disappear, antipruritic, can comedo be limited to, continue spot printing pustule recovery from illness in 8 days after removing pustule, then continue use after 20 days, face is smooth.
The patient at 20 16 ~ 35 years old age of example is tested (some pox elite formula or formula 2), inefficiency is 0, obvious effective rate is 100%, effective percentage 95%, and cure rate is 95%, wherein 1 example is only had to be cyst type, pox joins together, and local has pox to cheat, spot printing 28 days, can repellent antipruritic, but cyst fails to cure.And adopt some pox elite (comparative formula) to fail significant curative effect to comedo.As can be seen here, in elite, add antibacterial peptide can effective repellent antipruritic, significantly strengthens it to the curative effect of comedo.
Above content is in conjunction with concrete preferred implementation further description made for the present invention, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (5)
1. antibacterial peptide is as the application of antiinflammatory acne removing agent in cosmetics preparation, and it is characterized in that, described antibacterial peptide is extract or the crude extract of cecropin antimicrobial peptides.
2. antibacterial peptide according to claim 1, is characterized in that, described antibacterial peptide adopts liquid or powder.
3. application according to claim 1, is characterized in that, the cosmetics scope that is suitable for for but be not limited to: liquid type, emulsion class, cream kind, jelly class.
4. application according to claim 2, is characterized in that, the use amount of described antibacterial peptide in cosmetics is 0.01 ~ 50% of this cosmetics gross weight.
5. application according to claim 3, is characterized in that, adds in cosmetics when described antibacterial peptide is below 50 DEG C.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510919320.1A CN105411873A (en) | 2015-12-14 | 2015-12-14 | Application of antibacterial peptide as anti-inflammation acne removal agent for cosmetic preparation |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510919320.1A CN105411873A (en) | 2015-12-14 | 2015-12-14 | Application of antibacterial peptide as anti-inflammation acne removal agent for cosmetic preparation |
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| Publication Number | Publication Date |
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| CN105411873A true CN105411873A (en) | 2016-03-23 |
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| CN201510919320.1A Pending CN105411873A (en) | 2015-12-14 | 2015-12-14 | Application of antibacterial peptide as anti-inflammation acne removal agent for cosmetic preparation |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106236695A (en) * | 2016-06-02 | 2016-12-21 | 哈尔滨源茂达生物技术有限公司 | One peptide species anti-acne repairs essence and preparation method thereof |
| CN106265223A (en) * | 2016-05-12 | 2017-01-04 | 哈尔滨源茂达生物技术有限公司 | One peptide species anti-acne skin rejuvenating facial mask and preparation method thereof |
| CN106473944A (en) * | 2016-12-15 | 2017-03-08 | 广东科玮生物技术股份有限公司 | A kind of acne-removing composition containing antibacterial peptide and acne eliminating cream |
| CN107383166A (en) * | 2017-08-07 | 2017-11-24 | 温州千瑞生物科技有限公司 | The peptide sensitive to Propiobacterium |
| CN107412745A (en) * | 2017-05-04 | 2017-12-01 | 湖北肽尔生物医疗科技有限公司 | Complex polypeptide liquid and preparation method and application |
| CN107698662A (en) * | 2017-10-24 | 2018-02-16 | 银川利智信知识产权咨询服务有限公司 | Treat the peptide combination of acne |
| CN108324586A (en) * | 2018-04-08 | 2018-07-27 | 北京皓尔生物科技有限公司 | A kind of antibacterial anti-inflammatory composition and its application |
| CN108403582A (en) * | 2018-04-08 | 2018-08-17 | 北京皓尔生物科技有限公司 | A kind of anti-acne, acne-removing composition and its application containing antibacterial peptide |
| CN109381392A (en) * | 2018-12-03 | 2019-02-26 | 天津郁美净集团有限公司 | A kind of composition and preparation method thereof with preservative efficacy |
| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
| CN112826757A (en) * | 2020-12-16 | 2021-05-25 | 中新国际联合研究院 | A kind of antibacterial and anti-inflammatory composite collagen essence and its preparation method and application |
| CN113398057A (en) * | 2020-12-22 | 2021-09-17 | 重庆中佳信健康管理有限公司 | Bacteriostatic agent and preparation method thereof |
| CN115487114A (en) * | 2022-10-12 | 2022-12-20 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
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Cited By (15)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN106265223A (en) * | 2016-05-12 | 2017-01-04 | 哈尔滨源茂达生物技术有限公司 | One peptide species anti-acne skin rejuvenating facial mask and preparation method thereof |
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| CN106473944B (en) * | 2016-12-15 | 2019-07-02 | 广东科玮生物技术股份有限公司 | A kind of acne-removing composition and acne eliminating cream containing antibacterial peptide |
| CN106473944A (en) * | 2016-12-15 | 2017-03-08 | 广东科玮生物技术股份有限公司 | A kind of acne-removing composition containing antibacterial peptide and acne eliminating cream |
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| CN107383166A (en) * | 2017-08-07 | 2017-11-24 | 温州千瑞生物科技有限公司 | The peptide sensitive to Propiobacterium |
| CN107698662A (en) * | 2017-10-24 | 2018-02-16 | 银川利智信知识产权咨询服务有限公司 | Treat the peptide combination of acne |
| CN108324586A (en) * | 2018-04-08 | 2018-07-27 | 北京皓尔生物科技有限公司 | A kind of antibacterial anti-inflammatory composition and its application |
| CN108403582A (en) * | 2018-04-08 | 2018-08-17 | 北京皓尔生物科技有限公司 | A kind of anti-acne, acne-removing composition and its application containing antibacterial peptide |
| CN109381392A (en) * | 2018-12-03 | 2019-02-26 | 天津郁美净集团有限公司 | A kind of composition and preparation method thereof with preservative efficacy |
| CN110279844A (en) * | 2019-01-31 | 2019-09-27 | 浙江星杭泰乐生物医药有限公司 | Artificial synthetic antimicrobial peptide is preparing application and inhibiting bacteria and diminishing inflammation acne-removing composition in inhibiting bacteria and diminishing inflammation acne-eliminating cosmetic or external medicine preparation |
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| CN113398057A (en) * | 2020-12-22 | 2021-09-17 | 重庆中佳信健康管理有限公司 | Bacteriostatic agent and preparation method thereof |
| CN115487114A (en) * | 2022-10-12 | 2022-12-20 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
| CN115487114B (en) * | 2022-10-12 | 2023-10-03 | 广东粤港澳大湾区黄埔材料研究院 | Antibacterial peptide composition, acne-removing cream containing antibacterial peptide composition and preparation method of acne-removing cream |
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Application publication date: 20160323 |