CN105361970B - Animal skin breakage processor - Google Patents
Animal skin breakage processor Download PDFInfo
- Publication number
- CN105361970B CN105361970B CN201510625614.3A CN201510625614A CN105361970B CN 105361970 B CN105361970 B CN 105361970B CN 201510625614 A CN201510625614 A CN 201510625614A CN 105361970 B CN105361970 B CN 105361970B
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- CN
- China
- Prior art keywords
- knife rest
- regulating bolt
- bottom plate
- animal skin
- knife
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 241001465754 Metazoa Species 0.000 title claims abstract description 37
- 230000001105 regulatory effect Effects 0.000 claims abstract description 42
- 230000008859 change Effects 0.000 claims abstract description 3
- 238000003825 pressing Methods 0.000 claims description 3
- 210000003491 skin Anatomy 0.000 abstract description 28
- 238000012360 testing method Methods 0.000 abstract description 15
- 206010052428 Wound Diseases 0.000 abstract description 12
- 208000027418 Wounds and injury Diseases 0.000 abstract description 12
- 239000002085 irritant Substances 0.000 abstract description 6
- 231100000021 irritant Toxicity 0.000 abstract description 6
- 241000283973 Oryctolagus cuniculus Species 0.000 abstract description 5
- 208000028990 Skin injury Diseases 0.000 abstract description 4
- 210000002615 epidermis Anatomy 0.000 abstract description 4
- 238000000034 method Methods 0.000 description 7
- 238000002474 experimental method Methods 0.000 description 5
- 238000002347 injection Methods 0.000 description 3
- 239000007924 injection Substances 0.000 description 3
- 238000005457 optimization Methods 0.000 description 3
- 238000005192 partition Methods 0.000 description 3
- 230000009467 reduction Effects 0.000 description 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 2
- 238000010171 animal model Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 230000007812 deficiency Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 241000700199 Cavia porcellus Species 0.000 description 1
- 241001269238 Data Species 0.000 description 1
- 206010024769 Local reaction Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 238000005520 cutting process Methods 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 239000000645 desinfectant Substances 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000003780 insertion Methods 0.000 description 1
- 230000037431 insertion Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
- 229940033663 thimerosal Drugs 0.000 description 1
Landscapes
- Sampling And Sample Adjustment (AREA)
Abstract
A kind of animal skin breakage processor, it includes bottom plate, the top of bottom plate is provided with body, knife rest is movably installed with body, the bottom of the knife rest is provided with two blades arranged side by side, the edge of a knife of blade lower end passes through bottom plate, and regulating bolt is provided with described body, can change the height that the edge of a knife exposes bottom plate by turn regulating bolt.Described body is provided with vertical slide rail, and described knife rest is sleeved on slide rail.One end arc of the bottom plate is tilted, and Anti-slip handle is provided with tilting end.Post one layer of mantle in the bottom surface of the bottom plate.The present invention is used for damaged skin irritant test, and broken skin is carried out to subjects such as rabbit or cavys, adjusts edge height by regulating bolt, can easily accomplish skin injury only up to epidermis, not injure corium.As long as intersect stroke can on skin standardized " well " shape damaged wound, it is ensured that the depth consistency of wound, reduce test error, there is the advantages of easy to operate, accuracy is high, meet the requirement of " 3R " principle.
Description
Technical field
The present invention relates to a kind of cutter for being used to test, specifically one kind is used to pierce in damaged skin irritant test
The instrument of broken animal skin.
Background technology
Damaged skin irritant test is mainly for detection of disinfectant to stimulation/corrosiveness of experimental animal skin and strong
Degree.Experiment at least needs the intact healthy rabbits of 3 skins or cavy every time, rabbit or guinea pig back backbone both sides is local
Hair removes, and is cleaned with alcohol, sterilize exposed skin, after alcohol volatilization, with sterilize blade or injection needle in dermatotome it is standardized
The damaged wound of individual " well " shape, and contaminated in the damaged dermatotome.Then tested thimerosal is dropped in brokenly in area, observes skin
Local reaction, and carry out stimulate the reaction scoring.
The major defect or deficiency of conventional treatment mode：The test requirements document skin injury only up to epidermis, it is impossible to corium is injured,
Otherwise, this animal must just be abandoned.Therefore, the preparation of the damaged wound of " well " shape turns into the institute of the key of the success of the test
.And there is larger limitation in conventional partition method.When conventional use sterilizing blade or injection needle carry out partition,
Usually corium can be injured due to the bad grasp of dynamics.Further, since the damaged wound of standardized " well " shape is wanted, with routine
Method must draw four knives, and all that has been achieved is spoiled if last knife wound and corium.This also imply that this animal by
Also have to it be abandoned after skin pain.This does not largely meet the requirement of animal welfare and " 3R " principle.
" 3R " is substituted（Replacement）, reduce（Reduction）And optimization（Refinement）Three English are single
The prefix of word.3R is as a Systems Theory most early in nineteen fifty-nine british animal scholar William Russell and microbiology
Family Rex Burch are proposed, are then gradually obtained the approval of numerous scientific workers in world wide, are widely adopted.Particularly
In the past 20 years, as the fast development of biotechnology, understanding of the people to 3R deepen constantly, 3R concept is also continuously available expansion
Exhibition, and become more and more popular." replacement " refers to that use does not have sentient experiment material to replace living animal, or using low
Tested Deng animal replacement higher mammal, and obtain the scientific method of identical experiment effect." reduction " refers in scientific research
In, in zoopery, obtain test data as much using less amount of animal or can be obtained using a number of animal
The scientific method of more test datas is obtained, the purpose of reduction is not only to reduce cost, but is reached with the animal of minimum
Required purpose, while be also that one kind of animal is protected." optimization " refers to when animal must be used to carry out relevant experiment,
Coverage and degree of the inhuman program to animal are reduced as far as possible, can avoided reducing by improve and perfect experimental arrangement
Or mitigate to pain caused by animal and uneasiness, or suitable living condition is provided for animal, to ensure the health of animal and health
It is happy, ensure results of animal reliability and improve the scientific method of Laboratory Animal Welfare.In a word, substitute, reduce, optimization is that
This independence and connect each other, be to make people will preferably scientific utilization and a kind of scientific method of Reasonable Protection animal and
Section.From this aspect, develop a kind of animal damaged skin processor reasonable in design, easy to operate have it is extremely important
Realistic meaning.
The content of the invention
The defects of it is an object of the invention to for above-mentioned prior art and deficiency, for people provide it is a kind of it is simple in construction,
Easy to operate animal damaged skin processor, for damaged skin irritant test.
To achieve the above object, the technical solution used in the present invention is：The animal skin breakage processor, it includes bottom
Plate, the top of bottom plate are provided with body, knife rest are movably installed with body, and the bottom of the knife rest is provided with two blades arranged side by side,
The edge of a knife of blade lower end passes through bottom plate, and regulating bolt is provided with described body, can change the edge of a knife by turn regulating bolt
Expose the height of bottom plate.
Described regulating bolt bottom is passed through on knife rest, and two jam nuts, jam nut difference are installed with regulating bolt
Above and below knife rest, make knife rest and regulating bolt axial restraint.
Described regulating bolt bottom is offseted with knife rest, and the bullet that cutter setting frame applies upward active force is provided with the lower section of knife rest
Spring.
Described regulating bolt bottom is provided with linkage section, and the diameter of linkage section is less than regulating bolt, described linkage section by
On down pass through knife rest, jump ring is set with linkage section, the jump ring is located at below knife rest, makes knife rest axially solid with regulating bolt
It is fixed.
The bottom of described regulating bolt is provided with disk, disk insertion knife rest, is equipped with disk overlying and is fixed with knife rest
Pressing plate, make knife rest and regulating bolt axial restraint.
Described body is provided with vertical slide rail, and described knife rest is sleeved on slide rail.
One end arc of the bottom plate is tilted, and Anti-slip handle is provided with tilting end.
Post one layer of mantle in the bottom surface of the bottom plate.
The present invention is used for damaged skin irritant test, broken skin is carried out to subjects such as rabbit or cavys, by adjusting spiral shell
Bolt adjusts edge height, can easily accomplish skin injury only up to epidermis, not injure corium.Can be in skin as long as intersecting stroke
The damaged wound of standardized " well " shape on skin, it is ensured that the depth consistency of wound, reduce test error, have it is easy to operate,
The advantages of accuracy is high, meet the requirement of " 3R " principle.
Brief description of the drawings
Fig. 1 is the structural representation of the present invention.
Fig. 2 is the sectional view of first embodiment of the invention.
Fig. 3 is the sectional view of second embodiment of the invention.
Fig. 4 is the sectional view of third embodiment of the invention.
Fig. 5 is the sectional view of fourth embodiment of the invention.
Embodiment
As shown in figure 1, the present invention is a kind of animal skin breakage processor, it is mainly used in damaged skin irritant test, it is right
The subjects such as rabbit or cavy carry out broken skin.It includes bottom plate 3, and the top of bottom plate 3 is provided with body 2, the activity peace in body 2
Equipped with knife rest 7, described body 2 is provided with vertical slide rail 14, and described knife rest 7 is sleeved on slide rail 14.Therefore 7, knife rest
It can be slided up and down in body 2, slide rail 14 also can prevent knife rest 7 from rotating or swinging.The bottom of the knife rest 7 be provided with two it is arranged side by side
Blade 6, the edge of a knife of the lower end of blade 6 pass through bottom plate 3, are provided with regulating bolt 1 on described body 2, pass through turn regulating bolt 1
The height that the edge of a knife exposes bottom plate 3 can be changed.According to different animal species, the height of the edge of a knife is adjusted, accomplishes skin injury only up to
Epidermis, the requirement of corium is not injured.
One end arc of the bottom plate 3 tilts, and is provided with Anti-slip handle 4 tilting end, sterilizing blade or injection than routine
Syringe needle more has gripping sense, is advantageous to dynamics control, improves success of the test rate.Pulled back by gripping Anti-slip handle 4, Jiu Hui
Two parallel wounds are left on the skin of animal.Because the arc of bottom plate 3 tilts, therefore the same of wound is scratched on animal skin
When can be clearly observed the process of edge of a knife cutting, person easy to operation adjusts in time.As long as intersect stroke, so that it may drawn on skin
The damaged wound of one " well " shape, it is convenient and swift.One layer of mantle 5 is posted in the bottom surface of the bottom plate 3, can be easy to bottom plate 3 and animal
The fitting of skin, make operation more accurate.Per pass wound is deep mixed when being therefore avoided that usual manner partition using the present invention
Phenomenon, improve the uniformity of experiment, reduce test error.With the advantages of easy to operate, accuracy is high, meet " 3R " principle
Requirement.
As shown in Fig. 2 in the first embodiment, the described bottom of regulating bolt 1 is passed through on knife rest 7, in regulating bolt 1
Two jam nuts 8 are installed with, jam nut 8 above and below knife rest 7, makes knife rest 7 axially solid with regulating bolt 1 respectively
It is fixed.Therefore in turn regulating bolt 1, knife rest 7 can move up and down with the rotation of regulating bolt 1.
As shown in figure 3, in a second embodiment, the described bottom of regulating bolt 1 offsets with knife rest 7, in the lower section of knife rest 7
Apply the spring 9 of upward active force provided with cutter setting frame 7.Therefore it can move down, adjust with movable knife rack 7 during 1 downward turn of regulating bolt
When saving 1 upward turn of bolt, the restoring force of spring 9 can move up with movable knife rack 7.
As shown in figure 4, in the third embodiment, the described bottom of regulating bolt 1 is provided with linkage section 11, linkage section 11 it is straight
Footpath is less than regulating bolt 1, and described linkage section 11 passes through knife rest 7, jump ring 10 is set with linkage section 11, the card from top to bottom
Spring 10 is located at the lower section of knife rest 7, makes knife rest 7 and the axial restraint of regulating bolt 1.Therefore in turn regulating bolt 1, knife rest 7 can be with
The rotation of regulating bolt 1 and move up and down.
As shown in figure 5, in the fourth embodiment, the bottom of described regulating bolt 1 is provided with disk 12, and the disk 12 is embedded in
Knife rest 7, the pressing plate 13 fixed with knife rest 7 is housed in the overlying of disk 12, makes knife rest 7 and the axial restraint of regulating bolt 1.Therefore revolving
During dynamic regulating bolt 1, knife rest 7 can move up and down with the rotation of regulating bolt 1.
Claims (7)
1. a kind of animal skin breakage processor, it is characterised in that it includes bottom plate（3）, bottom plate（3）Top be provided with body
（2）, in body（2）Inside it is movably installed with knife rest（7）, the knife rest（7）Bottom be provided with two blades arranged side by side（6）, blade（6）
The edge of a knife of lower end passes through bottom plate（3）, described body（2）On regulating bolt is installed（1）, pass through turn regulating bolt（1）Energy
Change the edge of a knife and expose bottom plate（3）Height；The bottom plate（3）One end arc tilt, be provided with Anti-slip handle tilting end（4）.
2. animal skin breakage processor according to claim 1, it is characterised in that described regulating bolt（1）Wear bottom
Cross knife rest（7）On, in regulating bolt（1）On be installed with two jam nuts（8）, jam nut is located at knife rest respectively（7）Top and
Lower section, make knife rest（7）With regulating bolt（1）Axial restraint.
3. animal skin breakage processor according to claim 1, it is characterised in that described regulating bolt（1）Bottom with
Knife rest（7）Offset, in knife rest（7）Lower section be provided with cutter setting frame（7）Apply the spring of upward active force（9）.
4. animal skin breakage processor according to claim 1, it is characterised in that described regulating bolt（1）Bottom is set
There is linkage section（11）, linkage section（11）Diameter be less than regulating bolt（1）, described linkage section（11）Knife rest is passed through from top to bottom
（7）, in linkage section（11）On be set with jump ring（10）, the jump ring（10）Positioned at knife rest（7）Lower section, make knife rest（7）With adjusting spiral shell
Bolt（1）Axial restraint.
5. animal skin breakage processor according to claim 1, it is characterised in that described regulating bolt（1）Bottom
Provided with disk（12）, the disk（12）Embedded knife rest（7）, in disk（12）Overlying is equipped with and knife rest（7）Fixed pressing plate（13）,
Make knife rest（7）With regulating bolt（1）Axial restraint.
6. according to any described animal skin breakage processors of claim 1-5, it is characterised in that described body（2）On set
There is vertical slide rail（14）, described knife rest（7）It is sleeved on slide rail（14）On.
7. according to any described animal skin breakage processors of claim 1-5, it is characterised in that the bottom plate（3）Bottom surface
Post one layer of mantle（5）.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510625614.3A CN105361970B (en) | 2015-09-28 | 2015-09-28 | Animal skin breakage processor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510625614.3A CN105361970B (en) | 2015-09-28 | 2015-09-28 | Animal skin breakage processor |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN105361970A CN105361970A (en) | 2016-03-02 |
| CN105361970B true CN105361970B (en) | 2018-01-30 |
Family
ID=55364945
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510625614.3A Active CN105361970B (en) | 2015-09-28 | 2015-09-28 | Animal skin breakage processor |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN105361970B (en) |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226315A (en) * | 1996-07-29 | 1999-08-18 | 莱卡显微系统努斯洛赫股份有限公司 | Disc-type slicer |
| CN101396304A (en) * | 2008-10-23 | 2009-04-01 | 华中科技大学同济医学院附属同济医院 | Vertebrate killing method and its sharp elastic cutting device |
| CN102293685A (en) * | 2011-08-09 | 2011-12-28 | 上海交通大学 | Animal skin cutting knife and application thereof |
| CN202128560U (en) * | 2011-06-30 | 2012-02-01 | 兰州大学第二医院 | Incision model capable of continuously adjusting different depths for animal experiment |
| CN104027182A (en) * | 2014-06-23 | 2014-09-10 | 中国农业科学院特产研究所 | Combined tool for animal intracutaneous cutting |
| CN205041554U (en) * | 2015-09-28 | 2016-02-24 | 宁波出入境检验检疫局检验检疫技术中心 | Damaged treater of animal skin |
-
2015
- 2015-09-28 CN CN201510625614.3A patent/CN105361970B/en active Active
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226315A (en) * | 1996-07-29 | 1999-08-18 | 莱卡显微系统努斯洛赫股份有限公司 | Disc-type slicer |
| CN101396304A (en) * | 2008-10-23 | 2009-04-01 | 华中科技大学同济医学院附属同济医院 | Vertebrate killing method and its sharp elastic cutting device |
| CN202128560U (en) * | 2011-06-30 | 2012-02-01 | 兰州大学第二医院 | Incision model capable of continuously adjusting different depths for animal experiment |
| CN102293685A (en) * | 2011-08-09 | 2011-12-28 | 上海交通大学 | Animal skin cutting knife and application thereof |
| CN104027182A (en) * | 2014-06-23 | 2014-09-10 | 中国农业科学院特产研究所 | Combined tool for animal intracutaneous cutting |
| CN205041554U (en) * | 2015-09-28 | 2016-02-24 | 宁波出入境检验检疫局检验检疫技术中心 | Damaged treater of animal skin |
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| Publication number | Publication date |
|---|---|
| CN105361970A (en) | 2016-03-02 |
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Address after: 315000 Block A, Qingyi Road, Ningbo High-tech Zone, Zhejiang Province Patentee after: Ningbo Entry-exit Inspection and Quarantine Bureau Technical Center of the People's Republic of China Address before: 315010 No. 9 Mayuan Road, Haishu District, Ningbo City, Zhejiang Province Patentee before: Ningbo Entry-exit Inspection and Quarantine Bureau Technical Center of the People's Republic of China |