CN102293685B - Animal skin cutting knife and application thereof - Google Patents
Animal skin cutting knife and application thereof Download PDFInfo
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- CN102293685B CN102293685B CN201110226950.2A CN201110226950A CN102293685B CN 102293685 B CN102293685 B CN 102293685B CN 201110226950 A CN201110226950 A CN 201110226950A CN 102293685 B CN102293685 B CN 102293685B
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- Prior art keywords
- animal skin
- base
- knife rest
- skin
- knife
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- Expired - Fee Related
Links
- 238000005520 cutting process Methods 0.000 title claims abstract description 26
- 238000003825 pressing Methods 0.000 claims description 7
- 238000003466 welding Methods 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 abstract description 9
- 238000011156 evaluation Methods 0.000 abstract description 8
- 238000013271 transdermal drug delivery Methods 0.000 abstract description 7
- 238000002360 preparation method Methods 0.000 abstract description 3
- 210000003491 skin Anatomy 0.000 description 29
- 239000003814 drug Substances 0.000 description 4
- 239000000463 material Substances 0.000 description 4
- 210000005093 cutaneous system Anatomy 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 238000007920 subcutaneous administration Methods 0.000 description 3
- 238000005260 corrosion Methods 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 210000002615 epidermis Anatomy 0.000 description 2
- 235000013861 fat-free Nutrition 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 229910000831 Steel Inorganic materials 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000012377 drug delivery Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 238000007373 indentation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 210000005036 nerve Anatomy 0.000 description 1
- 230000001537 neural effect Effects 0.000 description 1
- NJPPVKZQTLUDBO-UHFFFAOYSA-N novaluron Chemical compound C1=C(Cl)C(OC(F)(F)C(OC(F)(F)F)F)=CC=C1NC(=O)NC(=O)C1=C(F)C=CC=C1F NJPPVKZQTLUDBO-UHFFFAOYSA-N 0.000 description 1
- 206010033675 panniculitis Diseases 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000002441 reversible effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 210000004304 subcutaneous tissue Anatomy 0.000 description 1
- 229940043263 traditional drug Drugs 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
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Abstract
本发明的一种动物皮肤切割刀具，包括：一刀架；一刀片固定于所述刀架两端；所述刀架上还包括平衡与厚度调节装置。本发明的刀具可以任意调节分割皮肤的厚度，分割出动物皮肤的不同层，并且结构简单、设计合理，制备成本非常便宜。切割的皮肤可用于体外评价微针透皮给药系统，由于目前还没有适合分割动物皮肤用的刀具，本发明填补了针对该类透皮给药系统的体外评价需要的分离出皮肤角质层的空白。
An animal skin cutting tool of the present invention comprises: a knife holder; a blade fixed at both ends of the knife holder; and a balance and thickness adjusting device is also included on the knife holder. The knife of the invention can adjust the thickness of the divided skin arbitrarily, and can divide different layers of the animal skin, and has simple structure, reasonable design and very cheap preparation cost. The cut skin can be used for in vitro evaluation of the microneedle transdermal drug delivery system. Since there is no cutting tool suitable for dividing animal skin at present, the present invention fills up the need to separate the cuticle of the skin for the in vitro evaluation of this type of transdermal drug delivery system. blank.
Description
Technical field
The present invention relates to technical field of mechanical cutting tool manufacture, relate in particular to a kind of animal skin cutting knife and application thereof.
Background technology
Along with scientific and technical development, transdermal drug delivery system is developed into microneedle cutaneous by traditional drug delivery system, the advantage of micropin medicine-feeding technology maximum is that it can hinder biggest obstacle---epidermis and the horny layer thereof of drug absorption thoroughly not injuring thorn under corium and neural prerequisite.Owing to not contacting nerve, micropin does not create a painful feeling to piercing through of epidermis, the reversible deformation that is even also skin for the Wicresoft of epidermis is greater than wound, micropin was removed in rear a few hours can reinstatement, and water soluble drug, comprise protein polypeptide, the pin hole that can sting out by micropin and effectively entering in body.
But traditional animal skin is owing to containing especially subcutaneous layer of fat of thicker subcutaneous tissue in vitro, this skin is difficult to be adapted to be similar to for evaluation the in vitro study of micropin transdermal.Due to microneedle cutaneous system, be exactly for horny layer, as long as micropin can pierce through horny layer and just can be used for evaluating its administering effect.Therefore, how isolating the horny layer of skin, is the problem that the in-vitro evaluation of at present such drug-supplying system is needed solution badly.
Summary of the invention
The present invention provides a kind of animal skin cutting knife and application thereof that animal skin can be divided into different-thickness in order to solve the problem of above-mentioned prior art existence.
Object of the present invention is achieved through the following technical solutions:
An animal skin cutting knife, comprising:
One knife rest;
One blade is fixed on described knife rest two ends;
On described knife rest, also comprise balance and thickness adjusting apparatus.
Preferably, described knife rest is 1/4 sphere-like.
Preferably, described blade is sawtooth pattern, linear type or annular saw flute profile, and blade two ends are screwed on knife rest, or with knife rest clamping, welding.
Preferably, described balance and thickness adjusting apparatus are some set screw or the micro actuator of being located at knife rest bottom.
Preferably, described cutter also comprises a base, and described knife rest is positioned at any direction on this base and on base and moves.
Preferably, described base is tabular.
Preferably, be also provided with one for fixing zoodermic fixed station on described base, this fixed station comprises the height adjustable pressing plate of base plate and base plate top.
Preferably, described base plate is groove shape, and base plate is fixed or is welded on by set screw on base, and pressing plate is flexibly connected with brace by screw, and brace is fixedly connected with base or base plate.
The application of animal skin cutting knife, described cutter is for being divided into different-thickness by animal skin.
Compared with prior art, the present invention has following beneficial effect:
The present invention is applied to the curative effect that field of medicaments animal isolated experiment is evaluated transdermal drug delivery system, for this class medicine-feeding technology, provides a kind of animal skin cutting knife and application thereof.
Cutter of the present invention can regulate arbitrarily the thickness of cutting apart skin, be partitioned into zoodermic different layers, if horny layer, horny layer and skin corium or horny layer and corium and subcutaneous non-fat deposit are as the skin layer of the 40-2000 micron of not fatty layer etc., and simple in structure, reasonable in design, preparation cost is very cheap.The skin of cutting can be used for the microneedle cutaneous system of in-vitro evaluation, and owing to not also being applicable to cutting apart at present the cutter that animal skin is used, the present invention has filled up the blank of isolating keratodermatitis for the in-vitro evaluation needs of such transdermal drug delivery system.
Accompanying drawing explanation
Fig. 1 is the structural representation of the embodiment of the present invention one;
Fig. 2 is the structural representation of the embodiment of the present invention two.
The specific embodiment
Below in conjunction with accompanying drawing, describe the present invention in detail.
Embodiment mono-
As shown in Figure 1, a kind of animal skin cutting knife, comprising: a knife rest 1, and knife rest 1 is 1/4 sphere-like, is welded or be spirally connected to form by some steel bars; At the two ends of knife rest 1 diametrical position, be fixed with a blade 2, the preferred sawtooth pattern of blade 2, linear type or annular saw flute profile, blade 2 two ends are screwed on knife rest 1, or with knife rest 1 clamping, welding, the blade edge of a knife is toward the outer side, parallel with horizontal line; In knife rest 1 bottom, be also provided with balance and thickness adjusting apparatus, this balance and thickness adjusting apparatus are three set screw 3(or the micro actuator that is divided into knife rest 1 bottom).
Embodiment bis-
As the preferred embodiments of the present invention, as shown in Figure 2, a kind of animal skin cutting knife, comprise that knife rest 1, blade 2 and balance and thickness adjusting apparatus are set screw 3, this cutter also comprises tabular pedestal 4, as the sheet material of rectangle corrosion resistant plate or other other shapes of material, knife rest 1 is placed on this base 4 and can on base 4, with any direction, moves.
Preferably, be also provided with one for fixing zoodermic fixed station on base 4, this fixed station comprises the height adjustable pressing plate 52 of base plate 51 and base plate top.Base plate 51 is square indentations, base plate 51 is fixed or is welded on base 4 by set screw, pressing plate 52 is square corrosion resistant plate (or sheet material of other other shapes of material), by screw, is flexibly connected with brace 53, and brace 53 is fixedly connected with base 4 or base plate 51.
Cutter of the present invention is for being divided into different-thickness by animal skin.During use, first the animal skin tissue through freezing of needs cutting is placed on fixed station, regulate the spacing of pressing plate and base plate, animal skin tissue is fixed, then knife rest is placed on base, regulates the set screw (or micro actuator) of knife rest bottom to make knife rest balance, and with fixed station on need the zoodermic thickness of cutting in same level, then follow rest, makes the edge of a knife aim at animal skin and cuts.
The present invention is applied to the curative effect that field of medicaments animal isolated experiment is evaluated transdermal drug delivery system, for this class medicine-feeding technology, provides a kind of animal skin cutting knife and application thereof.
Cutter of the present invention can regulate arbitrarily the thickness of cutting apart skin, be partitioned into zoodermic different layers, if horny layer, horny layer and skin corium or horny layer and corium and subcutaneous non-fat deposit are as the skin layer of the 40-2000 micron of not fatty layer etc., and simple in structure, reasonable in design, preparation cost is very cheap.The skin of cutting can be used for the microneedle cutaneous system of in-vitro evaluation, and owing to not also being applicable to cutting apart at present the cutter that animal skin is used, the present invention has filled up the blank of isolating keratodermatitis for the in-vitro evaluation needs of such transdermal drug delivery system.
Disclosed is above only several specific embodiments of the application, but the application is not limited thereto, and the changes that any person skilled in the art can think of, all should drop in the application's protection domain.
Claims (5)
1. an animal skin cutting knife, is characterized in that, comprising:
One knife rest;
One blade is fixed on described knife rest two ends;
On described knife rest, also comprise balance and thickness adjusting apparatus;
Described knife rest is 1/4 sphere-like;
Described blade is sawtooth pattern or linear type, and blade two ends are screwed on knife rest, or with knife rest clamping or welding;
Described balance and thickness adjusting apparatus are some micro actuators of being located at knife rest bottom;
Described cutter also comprises a base, and described knife rest is positioned at any direction on this base and on base and moves.
2. animal skin cutting knife as claimed in claim 1, is characterized in that, described base is tabular.
3. animal skin cutting knife as claimed in claim 1, is characterized in that, is also provided with one for fixing zoodermic fixed station on described base, and this fixed station comprises the height adjustable pressing plate of base plate and base plate top.
4. animal skin cutting knife as claimed in claim 3, is characterized in that, described base plate is groove shape, and base plate is fixed on base by welding or set screw, and pressing plate is flexibly connected with brace by screw, and brace is fixedly connected with base or base plate.
5. an application for animal skin cutting knife as claimed in claim 1, is characterized in that, described cutter is for being divided into different-thickness by Animal skin.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110226950.2A CN102293685B (en) | 2011-08-09 | 2011-08-09 | Animal skin cutting knife and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201110226950.2A CN102293685B (en) | 2011-08-09 | 2011-08-09 | Animal skin cutting knife and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN102293685A CN102293685A (en) | 2011-12-28 |
| CN102293685B true CN102293685B (en) | 2014-04-30 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201110226950.2A Expired - Fee Related CN102293685B (en) | 2011-08-09 | 2011-08-09 | Animal skin cutting knife and application thereof |
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Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103750922B (en) * | 2013-12-31 | 2016-07-13 | 金仕生物科技（常熟）有限公司 | The method preparing Cardiac valve prosthesis leaflet |
| CN104027182B (en) * | 2014-06-23 | 2016-08-24 | 中国农业科学院特产研究所 | A kind of animal skins internal cutting gang tool |
| CN104376772A (en) * | 2014-11-03 | 2015-02-25 | 力帆实业(集团)股份有限公司 | Rough clay model machining tool |
| CN105361970B (en) * | 2015-09-28 | 2018-01-30 | 宁波出入境检验检疫局检验检疫技术中心 | Animal skin breakage processor |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226315A (en) * | 1996-07-29 | 1999-08-18 | 莱卡显微系统努斯洛赫股份有限公司 | Disc-type slicer |
| CN101756628A (en) * | 2009-10-21 | 2010-06-30 | 刘博宇 | Novel fruit knife |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8100927B2 (en) * | 2007-11-28 | 2012-01-24 | Dadson Manufacturing Corp. | Dermatome with ultrasonic cutting blade |
-
2011
- 2011-08-09 CN CN201110226950.2A patent/CN102293685B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1226315A (en) * | 1996-07-29 | 1999-08-18 | 莱卡显微系统努斯洛赫股份有限公司 | Disc-type slicer |
| CN101756628A (en) * | 2009-10-21 | 2010-06-30 | 刘博宇 | Novel fruit knife |
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| Publication number | Publication date |
|---|---|
| CN102293685A (en) | 2011-12-28 |
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