CN105288698A - Calcium alginate composite medical surgical dressing and preparation method thereof - Google Patents
Calcium alginate composite medical surgical dressing and preparation method thereof Download PDFInfo
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- CN105288698A CN105288698A CN201510800580.7A CN201510800580A CN105288698A CN 105288698 A CN105288698 A CN 105288698A CN 201510800580 A CN201510800580 A CN 201510800580A CN 105288698 A CN105288698 A CN 105288698A
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- 229960002681 calcium alginate Drugs 0.000 title claims abstract description 40
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 title claims abstract description 40
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
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- 239000011248 coating agent Substances 0.000 claims abstract description 38
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 32
- 239000012792 core layer Substances 0.000 claims abstract description 27
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- 238000002156 mixing Methods 0.000 claims abstract description 18
- 235000011187 glycerol Nutrition 0.000 claims abstract description 17
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 claims abstract description 12
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Abstract
The invention belongs to the technical field of high-molecular medical biomaterials and relates to a calcium alginate composite medical surgical dressing and a preparation method thereof. The calcium alginate composite medical surgical dressing comprises an absorption core layer, a contact surface layer and a composite gel coating. The absorption core layer is a glue layer. The contact surface layer comprises chitosan fibers and active carbon fibers by blending. The composite gel coating comprises, by weight, 2-4 parts of sodium alginate, 0.5-1 part of medical glycerin, 2-4 parts of low molecular weight chitosan, 0.5-1 part of borneol and 80-100 parts of purified water. The medical surgical dressing prepared from the natural material and the synthetic high-molecular material has good absorbency, good biocompatibility, good biological activity and good mechanical properties.
Description
Technical field
The invention belongs to macromolecule medical biomaterial technical field, be specifically related to a kind of calcium alginate compounded medical dressing and preparation method thereof.
Background technology
Medical dressing, as the covering of wound, in wound healing process, can substitute impaired skin and play temporary barrier action, avoid or control wound infection, provide the environment being beneficial to wound healing.Along with the aging of population and increasing of chronic ulcerative wound, the market value of medical dressing also becomes more and more important.1962, British Winter proposed " wet wound healing is theoretical ", and namely wound is faster than healing under the environment of drying under moistening environment, makes the understanding of people to wound healing process have breakthrough progress.
Medical dressing can be divided into traditional dressing, biological dressing and synthetic dressing etc. according to its material.Wherein, biological dressing wide material sources, in adhesiveness, ease the pain, protect wound surface and reduce body fluid to ooze out etc. in respond well, therefore obtain the favor of people.But the permeability of some biological dressing, degradability, low antigenicity and promoting healing effect are also unsatisfactory.Desirable biological dressing should have following functions: cover and protect wound surface not infected; Good biocompatibility; There is biodegradability and suitable degradation rate; Enough mechanical strength sustenticular cell differentiation hypertrophy; Material surface has enough cell adsorption abilities, is conducive to adhesion and the growth of cell; Material source is sufficient, is easy to making, processing etc.Research and development have the biological dressing of multifunction, and making it reach the functional requirement of desirable dressing, is the study hotspot of current biological dressing.
The dressing major part absorbability that natural material is made is good, has good biocompatibility and biologic activity, but bad mechanical property.Synthesized polymer material isolation performance is good, and mechanical strength is good, but the relative natural material difference of absorbent properties.Therefore by the compound to material, the advantage of multiple material can be had concurrently, realizes the requirement of wound healing.
Water thorn process technology is used by extensive Bian in existing Medical dressing preparation, because the non-woven cloth cover of water thorn processing has excellent microcellular structure, this structure effectively can prevent dressing surface and wound adhesion, microcellular structure increases the specific surface area of structure, impart absorbability and the moisture-absorbing moisture-keeping ability of dressing uniqueness, therefore by the medical dressing of water acupuncture manipulation processing, there is the merit such as anti, high moisturizing, technology of preparing as medical dressing can industrialization large-scale production, greatly reduces production cost.
Summary of the invention
The object of the invention is to solve defect of the prior art, there is provided a kind of by natural material and the compounded medical dressing of synthesized polymer material, and possess good absorbability, good biocompatibility and biologic activity, there is good mechanical performance simultaneously.Realize antibacterial, moisturizing and there is the NEW TYPE OF COMPOSITE medical dressing of bleeding stopping and adherence preventing.Synergism between each layer and each component, has anastalsis, the healing of accelerated in wounds, can be widely used in clinical treatment while maintenance fungistatic effect lasting stability.
Technical scheme of the present invention is as follows: a kind of calcium alginate compounded medical dressing, and this based composite dressing for medical use is made up of absorbent core layer, contact surface layer and pluralgel coating; Described absorbent core layer is mucigel, described contact surface layer is formed by chitin fiber and NACF blending, and described pluralgel coating is counted by weight and consisted of the following composition: sodium alginate 2-4 part, medical glycerol 0.5-1 part, low-molecular weight chitoglycan 2-4 part, Borneolum Syntheticum 0.5-1 part, purified water 80-100 part.Utilize chitin fiber to have good antibacterial bacteriostatic performance, the morphosis of the hollow porous of NACF makes it have good absorption property, with the combination of pluralgel coating, realizes antibacterial, moisturizing and has the function of bleeding stopping and adherence preventing.Meanwhile, the synergism between each layer and each component, has anastalsis, the healing of accelerated in wounds while maintenance fungistatic effect lasting stability.
Preferably, the molecular weight of described low-molecular weight chitoglycan is 5000 ~ 10000Da, and deacetylation is 70% ~ 85%; The purity of described medical glycerol is greater than 99.8%.
Further, the two sides of described contact surface layer is coated with pluralgel coating.
Preferably, the thickness of described pluralgel coating is 1 ~ 5mm.
Further, described absorbent core layer carding, and is coated with the contact surface layer of pluralgel coating through high-pressure water-jet compound, forms calcium alginate compounded medical dressing.By high-pressure water-jet compound, form excellent microcellular structure, effectively prevent and wound adhesion, microcellular structure increases the specific surface area of structure, gives the good absorbability of dressing and moisture-absorbing moisture-keeping ability.
A preparation method for calcium alginate compounded medical dressing, described preparation method concrete technology step is as follows:
S1. absorbent core layer preparation: by viscose rayon, successively through shredding, combing and lapping, be absorbed sandwich layer;
S2. contact surface layer preparation: by chitin fiber and NACF mixing, send into cotton storage tank, lay is in heaps, vertical crawl is sent in mixing opening apparatus, loosens, dissociation, and mixing shredding, to even, by combing, lapping, obtains contact surface layer;
S3. pluralgel coating preparation: add in purified water by sodium alginate, low-molecular weight chitoglycan, Borneolum Syntheticum, mix and blend 1 ~ 2h, then add medical glycerol, stirs 5 ~ 10min to evenly, obtains pluralgel viscous solution;
S4. apply: the contact surface layer prepared by step S2 tiles under screen cloth, and the pluralgel viscous solution prepared by step S3 is coated onto on screen cloth, by scraper, pluralgel viscous solution is coated onto uniformly the two sides of contact surface layer; The dimensional parameters of described screen cloth is 30 × 40cm, 80 orders;
S5. lyophilization: the contact surface layer vacuum seal bag applied through step S4 is packaged, be put in reach in freezer and carry out 24h precooling, after put into vacuum freeze drier, regulate cryogenic temperature to keeping a period of time after-40 DEG C, carry out evacuation again, complete freezing dry process;
S6. water thorn compound: by the absorbent core layer prepared through the cryodesiccated contact surface layer of step S5 and step S1, prewet 1 time through high-pressure water-jet machine, front water stings 2 times, and reverse side water stings 2 times, obtained calcium alginate compounded medical dressing.
Further, the length 35mm-50mm of viscose rayon in described step S1, fineness is 1.3-2.5dtex; In described step S2, the length of chitin fiber is 25mm-55mm, and fineness is the length 30mm-45mm of 1.4-3.8dtex, NACF, and fineness is 1.2-3.0dtex.
Preferably, in described step S2, the percentage by weight of chitin fiber and NACF is 100%:0%, 80%:20%, 60%:40% or 50%:50%.
Further, in described step S6, the condition of water thorn compound is: adopt the direct water thorn of reinforcing mode, water barb spacing is from being 1.2cm, and water stings pressure: the 15bra that prewets, the anti-30bar of the positive 30bra of the anti-40bar of the positive 30bra of main thorn.
Beneficial effect of the present invention is: (1) the present invention adopts natural material and the compounded medical dressing of synthesized polymer material, and possesses good absorbability, good biocompatibility and biologic activity, has good mechanical performance simultaneously; (2) utilize chitin fiber to have good antibacterial bacteriostatic performance, the morphosis of the hollow porous of NACF makes it have good absorption property, with the combination of pluralgel coating, realizes antibacterial, moisturizing and has the function of bleeding stopping and adherence preventing.Meanwhile, the synergism between each layer and each component, has anastalsis, the healing of accelerated in wounds while maintenance fungistatic effect lasting stability; (3) by high-pressure water-jet compound, form excellent microcellular structure, effectively prevent and wound adhesion, microcellular structure increases the specific surface area of structure, gives the good absorbability of dressing and moisture-absorbing moisture-keeping ability; (4) Borneolum Syntheticum also has disinfective action, has cool feeling simultaneously, reduces wound circumference temperature, reduces pain and causalgia sense, and highly purified glycerol both can moisturizing, can play again the action time of prolongation based composite dressing for medical use.
Accompanying drawing explanation
Fig. 1 is each embodiment calcium alginate compounded medical dressing fracture strength scattergram;
Fig. 2 is each embodiment calcium alginate compounded medical dressing elongation at break scattergram.
Detailed description of the invention
Below in conjunction with embodiment, technical scheme of the present invention is described further.
embodiment 1
A kind of calcium alginate compounded medical dressing, this based composite dressing for medical use is made up of absorbent core layer, contact surface layer and pluralgel coating; Described absorbent core layer is mucigel, described contact surface layer is formed by chitin fiber and NACF blending, described pluralgel coating is counted by weight and is consisted of the following composition: sodium alginate 2 parts, medical glycerol 0.5 part, low-molecular weight chitoglycan 3 parts, Borneolum Syntheticum 0.5 part, purified water 94 parts, the molecular weight of described low-molecular weight chitoglycan is 5000Da, deacetylation is 70% ~ 85%, and the purity of described medical glycerol is greater than 99.8%.Utilize chitin fiber to have good antibacterial bacteriostatic performance, the morphosis of the hollow porous of NACF makes it have good absorption property, with the combination of pluralgel coating, realizes antibacterial, moisturizing and has the function of bleeding stopping and adherence preventing.Meanwhile, the synergism between each layer and each component, has anastalsis, the healing of accelerated in wounds while maintenance fungistatic effect lasting stability.
The two sides of described contact surface layer is coated with pluralgel coating, the thickness of described pluralgel coating is 1mm, described absorbent core layer carding, and is coated with the contact surface layer of pluralgel coating through high-pressure water-jet compound, forms calcium alginate compounded medical dressing.By high-pressure water-jet compound, form excellent microcellular structure, effectively prevent and wound adhesion, microcellular structure increases the specific surface area of structure, gives the good absorbability of dressing and moisture-absorbing moisture-keeping ability.
embodiment 2
A kind of calcium alginate compounded medical dressing, this based composite dressing for medical use is made up of absorbent core layer, contact surface layer and pluralgel coating; Described absorbent core layer is mucigel, described contact surface layer is formed by chitin fiber and NACF blending, described pluralgel coating is counted by weight and is consisted of the following composition: sodium alginate 3 parts, medical glycerol 0.8 part, low-molecular weight chitoglycan 2 parts, Borneolum Syntheticum 0.8 part, purified water 93.4 parts, the molecular weight of described low-molecular weight chitoglycan is 8000Da, deacetylation is 70% ~ 85%, and the purity of described medical glycerol is greater than 99.8%.Utilize chitin fiber to have good antibacterial bacteriostatic performance, the morphosis of the hollow porous of NACF makes it have good absorption property, with the combination of pluralgel coating, realizes antibacterial, moisturizing and has the function of bleeding stopping and adherence preventing.Meanwhile, the synergism between each layer and each component, has anastalsis, the healing of accelerated in wounds while maintenance fungistatic effect lasting stability.
The two sides of described contact surface layer is coated with pluralgel coating, the thickness of described pluralgel coating is 3mm, described absorbent core layer carding, and is coated with the contact surface layer of pluralgel coating through high-pressure water-jet compound, forms calcium alginate compounded medical dressing.By high-pressure water-jet compound, form excellent microcellular structure, effectively prevent and wound adhesion, microcellular structure increases the specific surface area of structure, gives the good absorbability of dressing and moisture-absorbing moisture-keeping ability.
embodiment 3
A kind of calcium alginate compounded medical dressing, this based composite dressing for medical use is made up of absorbent core layer, contact surface layer and pluralgel coating; Described absorbent core layer is mucigel, described contact surface layer is formed by chitin fiber and NACF blending, described pluralgel coating is counted by weight and is consisted of the following composition: sodium alginate 3.5 parts, medical glycerol 1 part, low-molecular weight chitoglycan 4 parts, Borneolum Syntheticum 1 part, purified water 90.5 parts, the molecular weight of described low-molecular weight chitoglycan is 10000Da, deacetylation is 70% ~ 85%, and the purity of described medical glycerol is greater than 99.8%.Utilize chitin fiber to have good antibacterial bacteriostatic performance, the morphosis of the hollow porous of NACF makes it have good absorption property, with the combination of pluralgel coating, realizes antibacterial, moisturizing and has the function of bleeding stopping and adherence preventing.Meanwhile, the synergism between each layer and each component, has anastalsis, the healing of accelerated in wounds while maintenance fungistatic effect lasting stability.
The two sides of described contact surface layer is coated with pluralgel coating, the thickness of described pluralgel coating is 5mm, described absorbent core layer carding, and is coated with the contact surface layer of pluralgel coating through high-pressure water-jet compound, forms calcium alginate compounded medical dressing.By high-pressure water-jet compound, form excellent microcellular structure, effectively prevent and wound adhesion, microcellular structure increases the specific surface area of structure, gives the good absorbability of dressing and moisture-absorbing moisture-keeping ability.
For whether the calcium alginate compounded medical dressing of checking the present invention reaches the invention effect of expection, carry out antibacterial tests and animal experiment analysis to the calcium alginate compounded medical dressing of the present invention, result is as follows:
Cause some pathogenic bacterium of wound infection mainly to comprise staphylococcus aureus, Candida albicans, coliform etc., this experiment is with the antibacterial effect of the calcium alginate compounded medical dressing of above-mentioned pathogenic bacterium testing example 1 ~ 3.As can be seen from the above table, calcium alginate compounded medical dressing prepared by the present invention has good antibacterial effect to most of pathogenic bacterium, there is good haemostatic effect, biocompatibility simultaneously, and safety non-toxic, can use safely, the resistance of skin can be improve, promote the metabolic capabilities of skin, moistening, aseptic healing environment can be provided to wound, promote the healing of wound.
embodiment 4
A preparation method for calcium alginate compounded medical dressing, described preparation method concrete technology step is as follows:
S1. absorbent core layer preparation: by length 35mm-50mm, fineness is 1.3-2.5dtex viscose rayon, successively by the shredding of BG038 type opener, the carding machine combing of BG218 type and cross lapping machine lapping, be absorbed sandwich layer;
S2. contact surface layer preparation: be that chitin fiber and the NACF of 60%:40% mixes by percentage by weight, send into cotton storage tank, lay is in heaps, vertical crawl is sent in mixing opening apparatus, loosen, dissociation, mixing shredding to even, after successively by the shredding of BG038 type opener, the carding machine combing of BG218 type and cross lapping machine lapping, obtain contact surface layer fibre web; The length of described chitin fiber is 25mm-55mm, and fineness is the length 30mm-45mm of 1.4-3.8dtex, NACF, and fineness is 1.2-3.0dtex;
S3. pluralgel coating preparation: add in 94 parts of purified water by 2 parts of sodium alginates, 3 parts of low-molecular weight chitoglycans, 0.5 part of Borneolum Syntheticum, mix and blend 1 ~ 2h, then add 0.5 part of medical glycerol, stirs 5 ~ 10min to evenly, obtains pluralgel viscous solution;
S4. apply: the contact surface layer prepared by step S2 tiles under screen cloth, and the pluralgel viscous solution prepared by step S3 is coated onto on screen cloth, by scraper, pluralgel viscous solution is coated onto uniformly the two sides of contact surface layer; The dimensional parameters of described screen cloth is 30 × 40cm, 80 orders;
S5. lyophilization: the contact surface layer vacuum seal bag applied through step S4 is packaged, be put in reach in freezer and carry out 24h precooling, after put into vacuum freeze drier, regulate cryogenic temperature to keeping a period of time after-40 DEG C, carry out evacuation again, complete freezing dry process;
S6. water thorn compound: adopt FieissnerAquajetY500-2 type spun-laced machine, by the absorbent core layer prepared through the cryodesiccated contact surface layer of step S5 and step S1, prewet 1 time through high-pressure water-jet machine, front water stings 2 times, reverse side water stings 2 times, obtained calcium alginate compounded medical dressing; The condition of described water thorn compound is: adopt the direct water thorn of reinforcing mode, water barb spacing is from being 1.2cm, and water stings pressure: the 15bra that prewets, the anti-30bar of the positive 30bra of the anti-40bar of the positive 30bra of main thorn, the speed of production of spun-laced machine is 4m/min.
embodiment 5
A preparation method for calcium alginate compounded medical dressing, described preparation method concrete technology step is as follows:
S1. absorbent core layer preparation: by length 35mm-50mm, fineness is 1.3-2.5dtex viscose rayon, successively by the shredding of BG038 type opener, the carding machine combing of BG218 type and cross lapping machine lapping, be absorbed sandwich layer;
S2. contact surface layer preparation: be that chitin fiber and the NACF of 80%:20% mixes by percentage by weight, send into cotton storage tank, lay is in heaps, vertical crawl is sent in mixing opening apparatus, loosen, dissociation, mixing shredding to even, after successively by the shredding of BG038 type opener, the carding machine combing of BG218 type and cross lapping machine lapping, obtain contact surface layer fibre web; The length of described chitin fiber is 25mm-55mm, and fineness is the length 30mm-45mm of 1.4-3.8dtex, NACF, and fineness is 1.2-3.0dtex;
S3. pluralgel coating preparation: add in 93.4 parts of purified water by 3 parts of sodium alginates, 2 parts of low-molecular weight chitoglycans, 0.8 part of Borneolum Syntheticum, mix and blend 1 ~ 2h, then add 0.8 part of medical glycerol, stirs 5 ~ 10min to evenly, obtains pluralgel viscous solution;
S4. apply: the contact surface layer prepared by step S2 tiles under screen cloth, and the pluralgel viscous solution prepared by step S3 is coated onto on screen cloth, by scraper, pluralgel viscous solution is coated onto uniformly the two sides of contact surface layer; The dimensional parameters of described screen cloth is 30 × 40cm, 80 orders;
S5. lyophilization: the contact surface layer vacuum seal bag applied through step S4 is packaged, be put in reach in freezer and carry out 24h precooling, after put into vacuum freeze drier, regulate cryogenic temperature to keeping a period of time after-40 DEG C, carry out evacuation again, complete freezing dry process;
S6. water thorn compound: adopt FieissnerAquajetY500-2 type spun-laced machine, by the absorbent core layer prepared through the cryodesiccated contact surface layer of step S5 and step S1, prewet 1 time through high-pressure water-jet machine, front water stings 2 times, reverse side water stings 2 times, obtained calcium alginate compounded medical dressing; The condition of described water thorn compound is: adopt the direct water thorn of reinforcing mode, water barb spacing is from being 1.2cm, and water stings pressure: the 15bra that prewets, the anti-30bar of the positive 30bra of the anti-40bar of the positive 30bra of main thorn, the speed of production of spun-laced machine is 4m/min.
embodiment 6
A preparation method for calcium alginate compounded medical dressing, described preparation method concrete technology step is as follows:
S1. absorbent core layer preparation: by length 35mm-50mm, fineness is 1.3-2.5dtex viscose rayon, successively by the shredding of BG038 type opener, the carding machine combing of BG218 type and cross lapping machine lapping, be absorbed sandwich layer;
S2. contact surface layer preparation: be that chitin fiber and the NACF of 50%:50% mixes by percentage by weight, send into cotton storage tank, lay is in heaps, vertical crawl is sent in mixing opening apparatus, loosen, dissociation, mixing shredding to even, after successively by the shredding of BG038 type opener, the carding machine combing of BG218 type and cross lapping machine lapping, obtain contact surface layer fibre web; The length of described chitin fiber is 25mm-55mm, and fineness is the length 30mm-45mm of 1.4-3.8dtex, NACF, and fineness is 1.2-3.0dtex;
S3. pluralgel coating preparation: add in 90.5 parts of purified water by 3.5 parts of sodium alginates, 4 parts of low-molecular weight chitoglycans, 1 part of Borneolum Syntheticum, mix and blend 1 ~ 2h, then add 1 part of medical glycerol, stirs 5 ~ 10min to evenly, obtains pluralgel viscous solution;
S4. apply: the contact surface layer prepared by step S2 tiles under screen cloth, and the pluralgel viscous solution prepared by step S3 is coated onto on screen cloth, by scraper, pluralgel viscous solution is coated onto uniformly the two sides of contact surface layer; The dimensional parameters of described screen cloth is 30 × 40cm, 80 orders;
S5. lyophilization: the contact surface layer vacuum seal bag applied through step S4 is packaged, be put in reach in freezer and carry out 24h precooling, after put into vacuum freeze drier, regulate cryogenic temperature to keeping a period of time after-40 DEG C, carry out evacuation again, complete freezing dry process;
S6. water thorn compound: adopt FieissnerAquajetY500-2 type spun-laced machine, by the absorbent core layer prepared through the cryodesiccated contact surface layer of step S5 and step S1, prewet 1 time through high-pressure water-jet machine, front water stings 2 times, reverse side water stings 2 times, obtained calcium alginate compounded medical dressing; The condition of described water thorn compound is: adopt the direct water thorn of reinforcing mode, water barb spacing is from being 1.2cm, and water stings pressure: the 15bra that prewets, the anti-30bar of the positive 30bra of the anti-40bar of the positive 30bra of main thorn, the speed of production of spun-laced machine is 4m/min.
For having good mechanical performance after checking water thorn of the present invention compound, the present invention tests as follows.Utilize omnipotent mechanics machine to test and often organize laboratory sample, obtain the parameter such as fracture strength, elongation at break often organizing sample.
1. often organize the fracture strength data of laboratory sample
The fracture strength (Mpa) of laboratory sample often organized by table 1.
| 1 | 2 | 3 | AVE | Var | |
| Embodiment 4 | 0.6146 | 0.5297 | 0.6338 | 0.5927 | 0.045232 |
| Embodiment 5 | 0.7621 | 0.7244 | 0.5712 | 0.6859 | 0.082553 |
| Embodiment 6 | 0.5795 | 0.5102 | 0.544 | 0.5445 | 0.032546 |
2. often organize the elongation at break data of laboratory sample
The elongation at break (%) of laboratory sample often organized by table 2.
| 1 | 2 | 3 | AVE | Var | |
| Embodiment 4 | 34.615 | 42.308 | 39.538 | 38.82033 | 3.181388 |
| Embodiment 5 | 44.547 | 50.784 | 45.46633 | 46.93244 | 4.019456 |
| Embodiment 6 | 42.655 | 39.486 | 41.91633 | 41.35244 | 1.761996 |
From existing experimental data and Fig. 1, Fig. 2, calcium alginate compounded its fracture strength of Medical coating material strip meansigma methods 607.7kPa, and elongation at break is all more than 30%.This illustrates that calcium alginate compounded medical dressing prepared by the present invention has good mechanical performance, the basic instructions for use met as medical dressing.
Obviously, the above embodiment of the present invention is only for example of the present invention is clearly described, and is not the restriction to embodiments of the present invention; For those of ordinary skill in the field, can also make other changes in different forms on the basis of the above description, exhaustive without the need to also giving all embodiments here; All any amendments done within the spirit and principles in the present invention, equivalent to replace and improvement etc., within the protection domain that all should be included in the claims in the present invention.
Claims (9)
1. a calcium alginate compounded medical dressing, is characterized in that, this based composite dressing for medical use is made up of absorbent core layer, contact surface layer and pluralgel coating; Described absorbent core layer is mucigel, described contact surface layer is formed by chitin fiber and NACF blending, and described pluralgel coating is counted by weight and consisted of the following composition: sodium alginate 2-4 part, medical glycerol 0.5-1 part, low-molecular weight chitoglycan 2-4 part, Borneolum Syntheticum 0.5-1 part, purified water 80-100 part.
2. the calcium alginate compounded medical dressing of one according to claim 1, is characterized in that, the molecular weight of described low-molecular weight chitoglycan is 5000 ~ 10000Da, and deacetylation is 70% ~ 85%; The purity of described medical glycerol is greater than 99.8%.
3. the calcium alginate compounded medical dressing of one according to claim 1, is characterized in that, the two sides of described contact surface layer is coated with pluralgel coating.
4. the calcium alginate compounded medical dressing of one according to claim 3, is characterized in that, the thickness of described pluralgel coating is 1 ~ 5mm.
5. the calcium alginate compounded medical dressing of one according to claim 4, is characterized in that, described absorbent core layer carding, and is coated with the contact surface layer of pluralgel coating through high-pressure water-jet compound, forms calcium alginate compounded medical dressing.
6. the preparation method of a kind of calcium alginate compounded medical dressing according to any one of claim 1-5, is characterized in that, described preparation method concrete technology step is as follows:
S1. absorbent core layer preparation: by viscose rayon, successively through shredding, combing and lapping, be absorbed sandwich layer;
S2. contact surface layer preparation: by chitin fiber and NACF mixing, send into cotton storage tank, lay is in heaps, vertical crawl is sent in mixing opening apparatus, loosens, dissociation, and mixing shredding, to even, by combing, lapping, obtains contact surface layer;
S3. pluralgel coating preparation: add in purified water by sodium alginate, low-molecular weight chitoglycan, Borneolum Syntheticum, mix and blend 1 ~ 2h, then add medical glycerol, stirs 5 ~ 10min to evenly, obtains pluralgel viscous solution;
S4. apply: the contact surface layer prepared by step S2 tiles under screen cloth, and the pluralgel viscous solution prepared by step S3 is coated onto on screen cloth, by scraper, pluralgel viscous solution is coated onto uniformly the two sides of contact surface layer; The dimensional parameters of described screen cloth is 30 × 40cm, 80 orders;
S5. lyophilization: the contact surface layer vacuum seal bag applied through step S4 is packaged, be put in reach in freezer and carry out 24h precooling, after put into vacuum freeze drier, regulate cryogenic temperature to keeping a period of time after-40 DEG C, carry out evacuation again, complete freezing dry process;
S6. water thorn compound: by the absorbent core layer prepared through the cryodesiccated contact surface layer of step S5 and step S1, prewet 1 time through high-pressure water-jet machine, front water stings 2 times, and reverse side water stings 2 times, obtained calcium alginate compounded medical dressing.
7. the preparation method of a kind of calcium alginate compounded medical dressing according to any one of claim 6, is characterized in that, the length 35mm-50mm of viscose rayon in described step S1, and fineness is 1.3-2.5dtex; In described step S2, the length of chitin fiber is 25mm-55mm, and fineness is the length 30mm-45mm of 1.4-3.8dtex, NACF, and fineness is 1.2-3.0dtex.
8. the preparation method of a kind of calcium alginate compounded medical dressing according to any one of claim 6, it is characterized in that, in described step S2, the percentage by weight of chitin fiber and NACF is 100%:0%, 80%:20%, 60%:40% or 50%:50%.
9. the preparation method of a kind of calcium alginate compounded medical dressing according to any one of claim 6, it is characterized in that, in described step S6, the condition of water thorn compound is: adopt the direct water thorn of reinforcing mode, water barb spacing is from being 1.2cm, and water stings pressure: the 15bra that prewets, the anti-30bar of the positive 30bra of the anti-40bar of the positive 30bra of main thorn.
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| CN108837176A (en) * | 2018-06-26 | 2018-11-20 | 东莞市联洲知识产权运营管理有限公司 | A kind of MULTILAYER COMPOSITE medical dressing and preparation method thereof |
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| CN108837176A (en) * | 2018-06-26 | 2018-11-20 | 东莞市联洲知识产权运营管理有限公司 | A kind of MULTILAYER COMPOSITE medical dressing and preparation method thereof |
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Application publication date: 20160203 |