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CN105214343B - A kind of extraction suit of platelet rich plasma - Google Patents

A kind of extraction suit of platelet rich plasma Download PDF

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Publication number
CN105214343B
CN105214343B CN201510701168.XA CN201510701168A CN105214343B CN 105214343 B CN105214343 B CN 105214343B CN 201510701168 A CN201510701168 A CN 201510701168A CN 105214343 B CN105214343 B CN 105214343B
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syringe
piston
extraction
suit
blood
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CN105214343A (en
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杨海兵
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ZHANGJIAGANG GAOPINCHENG MEDICAL EQUIPMENT TECHNOLOGY Co Ltd
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ZHANGJIAGANG GAOPINCHENG MEDICAL EQUIPMENT TECHNOLOGY Co Ltd
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Abstract

The invention discloses a kind of extraction suit of platelet rich plasma, including the first syringe, second syringe, push rod and protective cap, blood sampling hole is offered on the leading section of the first syringe, protective cap is removably set on the leading section of the first syringe, second syringe can be slidably plugged in the rearward end of the first syringe along the longitudinal direction, first piston is arranged with the leading section of the second syringe, first piston mutually seals setting with the inwall of the first syringe, push rod is plugged in the rearward end of the second syringe and can be slided along the inner wall sealing of the second syringe, extracting suit also includes running through the flexible pipe of first piston axial face, inner chamber for connecting the first syringe and the second syringe.Completed under a closed environment during the entire process of rich platelet from taking a blood sample, being centrifuged to obtaining using the suit that extracts of the invention, effectively prevent by the possibility of bacterium or virus pollution, and the extraction process is convenient and easy, the rich platelet purity for obtaining is high, and the equipment cost for being used is low.

Description

A kind of extraction suit of platelet rich plasma
Technical field
The present invention relates to technical field of medical instruments, the extraction of more particularly to a kind of platelet rich plasma is set with.
Background technology
At present, to be typically based on blood taking needle, syringe, centrifuge tube, injection needle etc. a series of for the recovery of blood and separation process Medical appliance, uses program complexity, and the medical disposable material being related to also compares many, and sky can not be effectively prevented from operating process The pollution again of the external environments such as gas, inevitably influence is caused on the degree of purity of blood, or even during storage also In the presence of free hemoglobin inflammatory mediator and cell-stimulating product containing various concentrations etc. in certain haemolysis, blood coagulation, blood Phenomenon, while being also possible to be mixed with the impurity particle such as the microtissue such as lipochondrion chip and micro- aggressiveness, may cause various bad Reaction, thus limit certain applications.Equipment component unavoidably remains red blood cell component, less has removal leucocyte etc. The function of impurity, have impact on coagulation function, it is necessary to supplement blood platelet in addition, and operation inconvenience, and equipment is costly.
At present, following several extraction elements, such as patent be have also appeared(Application number:201320801217.3)Disclose one kind High concentration platelet rich plasma extraction element, the device is made up of liquid flowing tube, pipette, adapter sleeve, and blood is made by the device Contaminated possibility is avoided in centrifugal separation processes, but can not be kept away when venous blood is moved in pipette from liquid flowing tube There occurs and contact there is contaminated possibility with outside air with exempting from.Likewise, patent of invention(Application No. 201310539497.X)A kind of blood rich platelet separating and extracting process and device are disclosed, the extraction dress that the patent is used Put, although ensure that centrifugal process is in a closed space, but, when carrying out separation and Extraction using extraction suit, still Injector for medical purpose venous blood samples need to first be used, carried out again after the venous blood in syringe is injected into the separating extraction device from The heart operate, shift venous blood during, still inevitably come in contact with outside air, equally exist it is contaminated can Energy.It follows that existing extraction element, from blood sampling, is centrifuged to extraction, still can not thoroughly completely cut off and extraneous ring in whole process The contact in border, inevitably causes a certain degree of pollution to blood.
The content of the invention
It is an object of the invention to provide a kind of extraction suit of platelet rich plasma, extraction suit low cost, user Just, overall process no bacteria pollution, efficiently solves medical separation hematic machines step used in the prior art complicated, no The problem of pollution and high cost can effectively be controlled.
To reach above-mentioned purpose, the technical solution adopted by the present invention is:A kind of extraction suit of platelet rich plasma, it is described Extracting suit includes the first syringe, the second syringe, push rod and protective cap, and blood sampling is offered on the leading section of first syringe Hole, the protective cap is removably set on the leading section of first syringe, and second syringe can be slided along the longitudinal direction It is plugged in dynamicly in the rearward end of first syringe, first piston, described is arranged with the leading section of second syringe One piston mutually seals setting with the inwall of first syringe, and the push rod is plugged in the rearward end of second syringe and can Slided along the inner wall sealing of second syringe, the suit that extracts also includes running through the flexible pipe of the first piston axial face, The flexible pipe is used to connect first syringe with the inner chamber of second syringe.
Preferably, the suit that extracts also includes the 3rd syringe, and the push rod is plugged in the rearward end of the 3rd syringe Upper and can be slided along the inner wall sealing of the 3rd syringe, the 3rd syringe can slidably be plugged in described the along the longitudinal direction In the rearward end of two syringes, it is arranged with the leading section of the 3rd syringe and mutually seals setting with the inwall of second syringe Second piston, the second piston has hollow inner chamber, and the extraction suit also includes in the second piston inner chamber Filter for removing white blood cell, offer the piston hole communicated with its own inner chamber on the axial forward end face of the second piston.
It is further preferred that being provided with the filter membrane for leukocyte depletion in the filter for removing white blood cell.
It is further preferred that the filter membrane is by having hydrophilic melt-blown fine resin fiber after the modified treatment of multilayer What non-woven fabrics was laminated, wherein, the fiber string diameter of described non-woven fabrics is 6.25-25 μm, and non-woven fabrics aperture is 15-60 μm.
It is further preferred that the filter for removing white blood cell is mutually threadedly coupled with the 3rd syringe.
Preferably, the suit that extracts also includes the threeway syringe needle being mutually threadedly coupled with the blood sampling hole, three cleansing pin One end of head is provided with the pullover for being mutually threadedly coupled with the blood sampling hole, and remaining is respectively arranged at two ends with blood taking needle and injection needle.
Preferably, the suit that extracts also includes being locked for both located between first syringe and second syringe Fixed locking mechanism, the locking mechanism be used for prevent it is described extraction be sleeved in centrifugal process, second syringe with it is described First syringe is separated.
It is further preferred that the locking mechanism includes the stop with draw-in groove in the first back end of syringe portion Portion, the lug boss in the second syringe outer peripheral sidewall, the lug boss is engaged with the size of the draw-in groove, when described When on the length bearing of trend of the draw-in groove, locking mechanism unblock, second syringe can be along described for boss The interior wall slip of one syringe;When the lug boss deviates the length bearing of trend of the draw-in groove, the locking mechanism locking, institute The second syringe is stated still to be plugged in the rearward end of first syringe.
Preferably, the 3rd work that setting is mutually sealed with the second syringe inwall is also arranged with the leading section of the push rod Plug, the push rod is slided by the 3rd piston along the inner wall sealing of second syringe.
Preferably, external screw thread is offered in the outer peripheral sidewall in the blood sampling hole, is offered on the madial wall of the protective cap The internal thread coordinated with the blood sampling hole phase screw thread.
Due to the utilization of above-mentioned technical proposal, the present invention has following advantages compared with prior art:Rich blood of the invention The extraction suit of platelet-poor plasma, its simple structure, by the pushing pull of piston realizing the erythrocyte in blood, blood plasma Separate, the part for leaving as platelet rich plasma, from blood sampling, be centrifuged to extraction, whole operation process is closed Extraction suit in complete, effectively completely cut off and contacted with the external environment such as air, it is to avoid bacterium is with virus to blood Pollution, reduces the influence to blood platelet using effect, enhances hematoblastic service efficiency, and alleviates the economy of patient and bears Load, and pass through to increase a syringe and filter for removing white blood cell, will can also obtain eliminating leucocyte, some microtissue chips And blood platelet after the impurity such as micro- polymers, so as to be conducive to improving hematoblastic storage quality, it is to avoid it is that leucocyte brings and Hair disease.
Brief description of the drawings
Accompanying drawing 1 is the structural representation of the extraction suit of the platelet rich plasma described in embodiment 1;
Accompanying drawing 2 is the sectional view of the extraction suit of the platelet rich plasma described in embodiment 1;
Accompanying drawing 3 is the structural representation of the extraction suit of the platelet rich plasma described in embodiment 2;
Accompanying drawing 4 is the sectional view of the extraction suit of the platelet rich plasma described in embodiment 2;
Accompanying drawing 5 is the structural representation of threeway syringe needle in the extraction suit of platelet rich plasma of the present invention;
Accompanying drawing 6 is the structural representation of stop part on the first syringe in the extraction suit of platelet rich plasma of the present invention Figure;
Wherein:11st, the first syringe;110th, blood sampling hole;111st, stop part;112nd, draw-in groove;12nd, the second syringe;121st, it is raised Portion;13rd, the 3rd syringe;14th, push rod;15th, protective cap;16th, threeway syringe needle;160th, pullover;161st, blood taking needle;162nd, injection needle; 163rd, blood sampling valve;164th, introduction valve;
21st, first piston;22nd, second piston;23rd, the 3rd piston;24th, filter for removing white blood cell;25th, flexible pipe.
Specific embodiment
Below in conjunction with the accompanying drawings and specific embodiment the present invention will be further described in detail.
Embodiment 1
Referring to shown in Fig. 1, Fig. 2, a kind of extraction suit of platelet rich plasma, extraction suit include the first syringe 11, Second syringe 12, push rod 14 and protective cap 15.
Blood sampling hole 110 is offered on the leading section of first syringe 11, protective cap 15 is removably set in the first syringe On 11 leading section.In order to prevent in centrifugal process, there is protective cap 15 and depart from the first syringe 11, cause blood sampling hole 110 naked Dew in atmosphere, causes the phenomenon of the pollution of venous blood, in this example, external screw thread is offered in the outer peripheral sidewall in the blood sampling hole 110, The internal thread coordinated with the phase screw thread of the blood sampling hole 110 is offered on the inwall of protective cap 15.
Second syringe 12 can slidably be plugged in the rearward end of the first syringe 11 along the longitudinal direction, the second syringe 12 First piston 21 is arranged with leading section, the first piston 21 mutually seals setting with the inwall of the first syringe 11, herein, in order to The fastness of connection is improved, is offered on the leading section of second syringe 12 with externally threaded interface, the first piston 21 and the Interface on the leading section of two syringes 12 is mutually threadedly coupled.The push rod 14 is plugged in the rearward end of the second syringe 12 and can be along The inner wall sealing of two syringes 12 is slided.Herein, the 3rd piston 23, the 3rd piston are also arranged with the leading section of the push rod 14 23 mutually seal setting with the inwall of the second syringe 12, by the 3rd piston 23, the push rod 14 along the second syringe 12 inner wall sealing Slide, certainly, for the fixing of connection, before the 3rd piston 23 can be connected to the push rod 14 by the way of threaded connection On end.
Extraction suit also includes the flexible pipe 25 through the axial face of first piston 21, and the flexible pipe 25 is used to connect the first syringe 11 and second syringe 12 inner chamber.
Extraction suit also includes the threeway syringe needle 16 being mutually threadedly coupled with blood sampling hole 110, one end of the threeway syringe needle 16 The pullover 160 for being mutually threadedly coupled with blood sampling hole 110 is provided with, remaining is respectively arranged at two ends with blood taking needle 161 and injection needle 162, The threeway syringe needle 16 also includes the blood sampling valve 163 for controlling blood sampling situation, the injection needle 162 1 located at the one end of blood taking needle 161 The introduction valve 164 for controlling ejection situation at end(As shown in Figure 5).
Comprising the following steps that for platelet rich plasma is extracted using said extracted suit:
1)Blood collection
1.1 are sterilized threeway syringe needle 16 and extraction suit using oxirane, then by threeway syringe needle 16 by set First 160 are connected on the blood sampling hole 110 for extracting suit;
1.2 selection puncture vessels are taken a blood sample, and blood vessel should select the high-visible vein for being difficult to slide of ancon, such as elbow center Vein, cephalic vein, basilic vein etc., during blood sampling, first carry out disinfection to blood sampling site, then confirm the blood sampling on threeway syringe needle 16 Valve 163 is opened, introduction valve 164 is closed, the second syringe of pull 12, carries out extracting in blood to extraction suit by blood taking needle 161, Volume markings are carved with the barrel of the first syringe 11, by the blood flow volume for observing scale to determine to extract;
After 1.3 blood samplings, confirm that the blood sampling valve 163 on threeway syringe needle 16 is closed, introduction valve 164 is opened, by injection needle 162 Extract the desired amount of anti-coagulants and mix with the blood extracted in suit;
1.4 back out threeway syringe needle 16, and protective cap 15 is set on blood sampling hole 110, complete the collection of blood sample;
2)Centrifugation
2.1 are vertically placed in suit is extracted in centrifuge, wherein, blood sampling hole 110 downwards, phase is installed additional with balance pipe The physiological saline of weight is answered to be balanced, centrifugation again;
2.2 centrifugations are taken out and extract suit to blood layering, remove protective cap 15, will be extracted suit and are gently pushed away vertically downward Dynamic second syringe 12, drives first piston 21 to move down, and the red blood cell in the first syringe 11 positioned at lower floor is extruded, and abandons it, Leave the blood platelet of centre and the blood plasma on upper strata;
2.3 put protective cap 15 again, will extract suit and be placed in second centrifugation is carried out in centrifuge, after centrifugation is finished, take Go out extraction element, remove protective cap 15, suit will be extracted and gently promote the second syringe 12 vertically downward, drive first piston 21 to Lower movement, by red blood cell extrusion remaining in the first syringe 11;
3)Detach extraction
After removal red blood cell, push rod 14 is vertically gently pulled, drive the 3rd piston 23 to move up, lived by through first Fill in the flexible pipe 25 of 21 axial faces and will be located at the blood platelet of lower floor in the first syringe 11 and suck in the second syringe 12, needed for obtaining final product us Platelet rich plasma, and the blood plasma stayed in the first syringe 11 pushed away by gently promoting the second syringe 12.
4)Install and use
When platelet rich plasma is used, the second syringe 12 is screwed out from the first syringe 11, remove first piston 21, the Injection needle 162 or spraying nozzle are installed on the interface of the leading section of two syringe 12 can be used wound.
Herein, in order to prevent in centrifugal process, the first syringe 11 is separated with the second syringe 12.In the present embodiment, Extraction suit is also included located at the locking mechanism locked for both between the first syringe 11 and the second syringe 12.The locking machine Structure is including the stop part 111 with draw-in groove 112 in the rearward end of the first syringe 11, in the outer peripheral sidewall of the second syringe 12 Lug boss 121, as shown in fig. 6, the lug boss 121 is engaged with the size of draw-in groove 112, when the lug boss 121 is located at draw-in groove 112 Length bearing of trend on when, the locking mechanism unblock, the second syringe 12 can be along the interior wall slip of the first syringe 11;Work as lug boss During the length bearing of trend of 121 deviation draw-in grooves 112, locking mechanism locking, the second syringe 12 is still plugged in the first syringe 11 Rearward end on, for the ease of lug boss 121 be aligned draw-in groove 112, be labeled with the lateral wall of first syringe 11 ON instruction Line, the length bearing of trend of the instruction line is consistent with the length bearing of trend of the draw-in groove 112.Specifically, working as, centrifugation behaviour need to be carried out When making, then the second syringe 12 is rotated, the lug boss 121 in the outer peripheral sidewall of the second syringe 12 is deviateed on the lateral wall of the first syringe 11 ON instruction lines, lock locking mechanism;After centrifugation terminates, when need to carry out draw operation to the second syringe 12, then is rotated Two syringes 12, make the lug boss 121 in the outer peripheral sidewall of the second syringe 12 be directed at ON instruction lines.
Embodiment 2
The difference part of the present embodiment and embodiment 1 is that increased the 3rd syringe 13 in the present embodiment and go white thin Born of the same parents' filter 24, so that can further by Impurity removals such as the leucocyte in blood platelet, some microtissue chips and micro- polymers.
In the present embodiment, referring to shown in Fig. 3, Fig. 4, extraction suit also includes the 3rd syringe 13, and push rod 14 is plugged in the Can slide in the rearward end of three syringes 13 and along the inner wall sealing of the 3rd syringe 13, the 3rd syringe 13 can slide along the longitudinal direction Be plugged in the rearward end of the second syringe 12.Herein, likewise, being arranged with the 3rd piston on the leading section of push rod 14 23, the 3rd piston 23 mutually seals setting with the inwall of the 3rd syringe 13.It is arranged with the leading section of the 3rd syringe 13 and The inwall of two syringes 12 mutually seals the second piston 22 of setting, and the second piston 22 has hollow inner chamber, and extraction suit is also Including the filter for removing white blood cell 24 in the inner chamber of second piston 22, offered on the axial forward end face of the second piston 22 The piston hole communicated with its own inner chamber.In order to ensure the fastness of connection, 22 points of the filter for removing white blood cell 24, second piston It is not threadedly coupled mutually with the 3rd syringe 13.Herein, it also is provided with externally threaded interface on the leading section of the 3rd syringe 13, should Filter for removing white blood cell 24 is mutually threadedly coupled with the interface.
In the present embodiment, be provided with the filter membrane for leukocyte depletion in the filter for removing white blood cell 24, the filter membrane be by Have what hydrophilic melt-blown fine resin fabric nonwoven cloth was laminated after the modified treatment of multilayer, wherein, every layer of non-woven fabrics Fiber string diameter be 6.25-25 μm, non-woven fabrics aperture be 15-60 μm.Herein, PBT or PET resin fiber is can select to prepare Above-mentioned non-woven fabrics.The filter membrane being made of above-mentioned material, its filtering accuracy is high.Blood platelet after the filter membrane, as removes The platelet rich plasma of the impurity such as leucocyte, some microtissue chips and micro- polymers.
It is red eliminating on the basis of embodiment 1 during the extraction of the present embodiment is sleeved on extraction rich platelet After cell, the 3rd syringe 13 is pulled, the blood platelet in the first syringe 11 is pumped to in the second syringe 12 by flexible pipe 25, and The second syringe 12 is promoted to extrude unnecessary blood plasma afterwards, then pull push rod 14, makes the blood platelet in the second syringe 12 through second It is pumped in the 3rd syringe 13 after piston 22, filter for removing white blood cell 24, now, the blood platelet in the 3rd syringe 13 is and removes The platelet rich plasma of the impurity such as leucocyte.When using, the 3rd syringe 13 is screwed out from the second syringe 12, screw out second and live Plug 22 and filter for removing white blood cell 24, install injection needle 162 or spraying nozzle on the leading section interface of the 3rd syringe 13 Wound is used.
To sum up, the extraction suit of platelet rich plasma of the invention, from taking a blood sample, being centrifuged to the whole of platelet rich plasma is obtained It is to be completed in closed system during individual, efficiently avoid in the prior art, is extracting platelet rich plasma when institute The pollution problem being likely encountered, the red blood cell of lower floor and the blood plasma on upper strata go after pull syringe will can be layered in blood Remove, obtain platelet rich plasma, and pass through to increase filter for removing white blood cell 24, can by leucocyte in platelet rich plasma etc. its His some Impurity removals, obtain eliminating the platelet rich plasma of leucocyte, efficiently avoid white thin in use The complication that born of the same parents are brought.
The above embodiments merely illustrate the technical concept and features of the present invention, its object is to allow person skilled in the art Scholar will appreciate that present disclosure and be carried out that it is not intended to limit the scope of the present invention, all according to the present invention The equivalent change or modification that Spirit Essence is made, should all cover within the scope of the present invention.

Claims (5)

1. the extraction of a kind of platelet rich plasma is set with, it is characterised in that:The suit that extracts includes the first syringe, the second pin Cylinder, the 3rd syringe, push rod and protective cap, offer blood sampling hole on the leading section of first syringe, the protective cap is detachable Be set on the leading section of first syringe, external screw thread, the protective cap are offered in the outer peripheral sidewall in the blood sampling hole Madial wall on offer with the blood sampling hole phase screw thread coordinate internal thread, second syringe can along the longitudinal direction slidably It is plugged in the rearward end of first syringe, first piston is arranged with the leading section of second syringe, described first lives Plug mutually seals setting with the inwall of first syringe, and the 3rd syringe can slidably be plugged in described second along the longitudinal direction In the rearward end of syringe, be arranged with the leading section of the 3rd syringe with the inwall of second syringe mutually seal setting, Second piston with hollow cavity, the piston communicated with its own inner chamber is offered on the axial forward end face of the second piston Hole, the push rod is plugged in the rearward end of the 3rd syringe and can be slided along the inner wall sealing of the 3rd syringe, described Extracting suit also includes running through flexible pipe, the leucocyte-removing mistake in the second piston inner chamber of the first piston axial face Filter and the locking mechanism locked for both located between first syringe and second syringe, the flexible pipe are used for The inner chamber of first syringe and second syringe is connected, the locking mechanism was centrifuged for preventing the extraction to be sleeved on Second syringe described in journey is separated with first syringe, and the locking mechanism is included in the first back end of syringe portion The stop part with draw-in groove, the lug boss in the second syringe outer peripheral sidewall, the lug boss is big with the draw-in groove It is small to be engaged, when the boss is on the length bearing of trend of the draw-in groove when, the locking mechanism unblock, described second Syringe can be along the interior wall slip of first syringe;It is described when the lug boss deviates the length bearing of trend of the draw-in groove Locking mechanism is locked, and second syringe is still plugged in the rearward end of first syringe.
2. the extraction of platelet rich plasma according to claim 1 is set with, it is characterised in that:The filter for removing white blood cell Inside it is provided with the filter membrane for leukocyte depletion.
3. the extraction of platelet rich plasma according to claim 2 is set with, it is characterised in that:The filter membrane is passed through by multilayer Have what hydrophilic melt-blown fine resin fabric nonwoven cloth was laminated after modification, wherein, the fiber of described non-woven fabrics String diameter is 6.25-25 μm, and non-woven fabrics aperture is 15-60 μm.
4. the extraction of platelet rich plasma according to claim 1 is set with, it is characterised in that:The filter for removing white blood cell Mutually it is threadedly coupled with the 3rd syringe.
5. the extraction of platelet rich plasma according to claim 1 is set with, it is characterised in that:The suit that extracts also includes The threeway syringe needle being mutually threadedly coupled with the blood sampling hole, one end of the threeway syringe needle be provided with for the blood sampling hole phase screw thread The pullover of connection, remaining is respectively arranged at two ends with blood taking needle and injection needle.
CN201510701168.XA 2015-10-26 2015-10-26 A kind of extraction suit of platelet rich plasma Active CN105214343B (en)

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CN205055494U (en) * 2015-10-26 2016-03-02 张家港高品诚医械科技有限公司 Rich blood platelet plasma draw suit

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