CN105213360B - Application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system - Google Patents
Application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system Download PDFInfo
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- CN105213360B CN105213360B CN201510649024.4A CN201510649024A CN105213360B CN 105213360 B CN105213360 B CN 105213360B CN 201510649024 A CN201510649024 A CN 201510649024A CN 105213360 B CN105213360 B CN 105213360B
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- BMSXLMLHAVJLRR-UHFFFAOYSA-N [I].OC(=O)CC(O)(CC(O)=O)C(O)=O Chemical compound [I].OC(=O)CC(O)(CC(O)=O)C(O)=O BMSXLMLHAVJLRR-UHFFFAOYSA-N 0.000 title claims abstract description 37
- 244000144972 livestock Species 0.000 title claims abstract description 19
- 239000003814 drug Substances 0.000 title claims abstract description 14
- 208000027954 Poultry disease Diseases 0.000 title claims abstract description 13
- 210000002249 digestive system Anatomy 0.000 title claims abstract description 10
- 206010012735 Diarrhoea Diseases 0.000 claims abstract description 16
- 244000144977 poultry Species 0.000 claims abstract description 15
- 241000222122 Candida albicans Species 0.000 claims abstract description 10
- 206010007134 Candida infections Diseases 0.000 claims abstract description 9
- 201000003984 candidiasis Diseases 0.000 claims abstract description 9
- 239000003795 chemical substances by application Substances 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 4
- 239000007921 spray Substances 0.000 claims description 3
- 238000007598 dipping method Methods 0.000 claims description 2
- 239000002552 dosage form Substances 0.000 claims description 2
- 239000008187 granular material Substances 0.000 claims description 2
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- 239000003826 tablet Substances 0.000 claims description 2
- 239000003595 mist Substances 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract description 7
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 24
- 239000000243 solution Substances 0.000 description 21
- 241000287828 Gallus gallus Species 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 238000012360 testing method Methods 0.000 description 9
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 8
- 201000010099 disease Diseases 0.000 description 8
- 229910052740 iodine Inorganic materials 0.000 description 8
- 239000011630 iodine Substances 0.000 description 8
- 239000003651 drinking water Substances 0.000 description 7
- 235000020188 drinking water Nutrition 0.000 description 7
- 238000010790 dilution Methods 0.000 description 6
- 239000012895 dilution Substances 0.000 description 6
- 229940079593 drug Drugs 0.000 description 4
- 210000004400 mucous membrane Anatomy 0.000 description 4
- 241000700605 Viruses Species 0.000 description 3
- 239000000645 desinfectant Substances 0.000 description 3
- 235000013305 food Nutrition 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- 241000271566 Aves Species 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 2
- 206010015150 Erythema Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Chemical compound OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 description 2
- ARUVKPQLZAKDPS-UHFFFAOYSA-L copper(II) sulfate Chemical compound [Cu+2].[O-][S+2]([O-])([O-])[O-] ARUVKPQLZAKDPS-UHFFFAOYSA-L 0.000 description 2
- 238000003745 diagnosis Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 230000003628 erosive effect Effects 0.000 description 2
- 210000001035 gastrointestinal tract Anatomy 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 230000003340 mental effect Effects 0.000 description 2
- 210000000214 mouth Anatomy 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 238000003672 processing method Methods 0.000 description 2
- 235000013599 spices Nutrition 0.000 description 2
- 235000015096 spirit Nutrition 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 230000001960 triggered effect Effects 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000588724 Escherichia coli Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 235000002710 Ilex cornuta Nutrition 0.000 description 1
- 241001310146 Ilex cornuta Species 0.000 description 1
- 235000010326 Osmanthus heterophyllus Nutrition 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 208000025865 Ulcer Diseases 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000000840 anti-viral effect Effects 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 229940095731 candida albicans Drugs 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 230000000249 desinfective effect Effects 0.000 description 1
- 238000002224 dissection Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 231100000321 erythema Toxicity 0.000 description 1
- 239000000686 essence Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 235000021393 food security Nutrition 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 208000024386 fungal infectious disease Diseases 0.000 description 1
- 230000002496 gastric effect Effects 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000003862 health status Effects 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 230000000977 initiatory effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 238000000034 method Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 235000021590 normal diet Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 231100000572 poisoning Toxicity 0.000 description 1
- 230000000607 poisoning effect Effects 0.000 description 1
- NLKNQRATVPKPDG-UHFFFAOYSA-M potassium iodide Substances [K+].[I-] NLKNQRATVPKPDG-UHFFFAOYSA-M 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 210000002345 respiratory system Anatomy 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 230000002087 whitening effect Effects 0.000 description 1
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- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
The invention discloses application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system.There is good therapeutic effect to poultry candidiasis and epidemic diarrhea of livestock and poultry disease through clinical trial certificate citric acid iodine.
Description
Technical field
The present invention relates to the new application of citric acid iodine, and in particular to citric acid iodine is preparing treatment livestock and poultry disease of digestive system
Medicine in application.
Background technology
Livestock and poultry absorb nutriment by alimentary canal, and the complicated molecule of feed is converted into simple point that body can be utilized
Son, is the core machine of " Zao Rou factories ", has direct influence to the immune and health of animal.The livestock and poultry occurred in breeding process
The disease of digestive tracts such as particular about food, food refusal, punishment in advance and diarrhea cause growth, and Growth Results are poor, health status lowly, be susceptible to suffer from other diseases,
It is one of significant challenge and problem of current aquaculture.
Poultry candidiasis is a kind of mycosis of the birds upper digestive tract as caused by Candida albicans, it is characterized in that upper
White pseudomembrane and ulcer occur for gastrointestinal mucosal, because crop increase often occurs in diseased chicken, therefore are commonly called as " big crop disease ".This sick death rate
It is relatively low, but this disease can bring serious immunosupress to birds, cause immune response low SI, constitution to slacken and disease-resistant difference.
Once condition is uncomfortable easily, the diseases such as respiratory tract, Escherichia coli, virus can be triggered, poultry is thin and weak, egg fowl egg drop reduction.This can give
Raiser brings huge loss.The disease only relies on simple treatment, its effect is not often good once occurring.Raiser is general
The item work such as the main disinfecting work by doing pouity dwelling place and drinking-water well are prevented.
The reason for causing livestock and poultry diarrhea is complicated, and each side factor such as bacterium, virus, parasite, poisoning, internal medicine, nutrition is equal
Livestock and poultry diarrhea can be triggered.The epidemic diarrhea disease of the wherein initiation such as bacterium, virus is most common.At present, for livestock and poultry diarrhea, especially
It is the obstinate diarrhea disease that can not find the cause of disease, through being used together frequently with the medicine such as antibacterial, antiviral, wastes medicine,
Leave lower serious generation bacterial resistance and food security equivalent risk.
Citric acid iodine is to be configured to solution by iodine, citric acid and KI, is then prepared by extracting drying technology
's.Citric acid iodine solution is a kind of rufous liquid disinfectant, be by Zhengdian Biological Tech. Co., Ltd., Foshan City develop it is new
Veterinary drug, the granted class novel chiral synthon of the People's Republic of China (PRC) three in 2014, the sterilization for mew, air.According to research reports, citric acid
Iodine solution is a kind of wide spectrum, efficient, noresidue, low stimulation, environment-friendlydisinfectant disinfectant, is another breakthrough wound in disinfectant field
Newly.But, its application in terms of animal fire-fighting system preventing and treating there is no report.
The content of the invention
To solve the problem of existing livestock and poultry disease of digestive system treatment is present, the present invention proposes prepared by a kind of citric acid iodine
Treat the application in the medicine of livestock and poultry disease of digestive system.
The technical proposal of the invention is realized in this way：
Application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system.
Further, the livestock and poultry disease of digestive system is poultry candidiasis and epidemic diarrhea of livestock and poultry disease.
Further, the administering mode of the citric acid iodine is administered for oral administration, spray delivery or dipping.
Further, the pharmaceutical dosage form of the citric acid iodine is solution, pulvis, pre-mixing agent, granule, tablet or micro-capsule
Agent.
Embodiment
Embodiment 1
The oral irritation test of citric acid iodine chicken
Trial drug：Citric acid iodine solution, from Zhengdian Biological Tech. Co., Ltd., Foshan City, (specification is 1000ml：Iodine
20g+ citric acid 100g+ KI 15g)；
Test method：10 Japanese instar chickling 50 is taken, body weight is randomly divided into 4 groups, every group 10, drunk respectively in 100 ± 10g
Water gives citric acid iodine solution (1:500), citric acid iodine solution (1:1000), citric acid iodine solution (1:2000), citric acid iodine
Solution (1:3000), no added medicament drinking water, continuous normal feeding 10 days, dissection visually observes chicken mucous membrane of mouth, tracheae
Whether mucous membrane, alimentary canal mucous membrane etc. have the bad pathological change such as redness, erosion.
Result of the test：After continuous feeding 10 days, except One's spirits are drooping, apocleisis phenomenon occurs in first group of part chicken, other are each
Group chicken is acted normally, and continued weight increases to 170 ± 10g, without becoming thin, the One's spirits are drooping, symptom such as do not search for food, illustrates other
Group chicken normal diet.Anatomic observation, it is red and swollen, rotten to the corn that tracheal mucosa occurs in first group of part chicken, other group of chicken oral cavity,
The mucous membranes such as tracheae, alimentary canal, the pathological change such as no erythema, erosion.
Conclusion (of pressure testing)：It these results suggest that, citric acid iodine solution presses 1:More than 1000 dilution oral administrations are that safety is stingless
Sharp.
Embodiment 2
Poultry candidiasis therapeutic effect
Trial drug：Citric acid iodine solution, from Zhengdian Biological Tech. Co., Ltd., Foshan City, (specification is 1000ml：Iodine
20g+ citric acid 100g+ KI 15g)；Copper sulphate：Wujiang canal auxiliary reagent factory.
Test method：Diagnosed according to clinical symptoms, the change of case cut open inspection etc., diagnosis is suffered from into chicken candidiasis
Diseased chicken be randomly divided into 4 groups, first group of administration citric acid iodine solution (1:2000), drinking water administration；Second group is given citric acid iodine
Solution (1:2000), spice is administered；3rd group is control group, gives copper sulphate (1:2000), drinking water administration；4th group is blank
Control group, is not administered, normal water；The equal successive administration of above group 7 days, after drug withdrawal, 3 days chicken group's mental status of Continuous Observation,
Calculate the cure rate and case fatality rate of each group chicken.Result of the test：It is shown in Table 1
The citric acid iodine solution of table 1 is to poultry candidiasis therapeutic test result
| Group | Case fatality rate (%) | Cure rate (%) |
| First group (drinking water administration group) | 0.83 | 99.17 |
| Second group (spice administration group) | 1.67 | 98.33 |
| 3rd group (control group) | 6.67 | 93.33 |
| 4th group (blank group) | 16.67 | 83.33 |
As shown in Table 1, citric acid iodine solution presses 1:2000 dilutions, drinking-water or spray delivery have good to poultry candidiasis
Good therapeutic effect, illustrates that citric acid iodine solution can effectively treat poultry candidiasis by proper proportion dilution.
Embodiment 3
Grice diarrhoea disease therapeuticing effect
Trial drug：Citric acid iodine solution, from Zhengdian Biological Tech. Co., Ltd., Foshan City, (specification is 1000ml：Iodine
20g+ citric acid 100g+ KI 15g).
Test method：Diagnosed according to clinical symptoms etc., diagnosis is randomly divided into 4 groups with diarrhea disease piglet, it is right
Different group piglets are by table 2 (the citric acid iodine solution of different proportion dilution is to grice diarrhoea therapeutic test packet and processing method)
Different disposal is carried out, after drug withdrawal, 3 days piglet mental status of Continuous Observation calculate the cure rate and case fatality rate of each group piglet.Experiment
As a result：It is shown in Table 3.
The citric acid iodine solution of the different proportion of table 2 dilution is to grice diarrhoea therapeutic test packet and processing method
The citric acid iodine solution of the different proportion of table 3 dilution is to grice diarrhoea therapeutic test result
| Group | Case fatality rate (%) | Cure rate (%) |
| Citric acid iodine high concentration group (1:1000) | 0 | 100 |
| Concentration group (1 in citric acid iodine:2000) | 1.25 | 98.75 |
| Citric acid iodine low concentration group (1:3000) | 3.75 | 96.25 |
| Blank group | 11.25 | 88.75 |
Conclusion (of pressure testing)：As shown in Table 3, citric acid iodine administration group has good cure rate to grice diarrhoea, illustrates to use Chinese holly
It is feasible and effective that rafter acid iodine solution dilutes drinking water administration treatment livestock and poultry diarrhea by a certain percentage.
Embodiment 4
Citric acid iodine pulvis preparation method
By citric acid iodine and conventional pulvis auxiliary material it is size-reduced, it is well mixed be prepared from, auxiliary material is specifically included：Anhydrous Portugal
Grape sugar, oral glucose, starch, soluble starch, corncob, yellow, the auxiliary whitening of auxiliary U.S. etc..
Embodiment 5
Citric acid iodine pre-mixing agent preparation method
The powdered or granular formulations that pre-mixing agent is uniformly mixed with matrix are added by citric acid iodine.
The foregoing is merely illustrative of the preferred embodiments of the present invention, is not intended to limit the invention, all essences in the present invention
God is with principle, and any modification, equivalent substitution and improvements made etc. should be included in the scope of the protection.
Claims (3)
1. application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system, the livestock and poultry disease of digestive system is
Poultry candidiasis and epidemic diarrhea of livestock and poultry disease.
2. application according to claim 1, it is characterised in that the administering mode of the citric acid iodine is is administered orally, spray
Mist is administered or dipping administration.
3. application according to claim 1, it is characterised in that characterized in that, the pharmaceutical dosage form of the citric acid iodine is
Solution, pulvis, pre-mixing agent, granule, tablet or microcapsules.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510649024.4A CN105213360B (en) | 2015-10-08 | 2015-10-08 | Application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510649024.4A CN105213360B (en) | 2015-10-08 | 2015-10-08 | Application of the citric acid iodine in the medicine for preparing treatment livestock and poultry disease of digestive system |
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| CN105213360B true CN105213360B (en) | 2017-10-17 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974815A (en) * | 2019-12-18 | 2020-04-10 | 佛山市正典生物技术有限公司 | Iodine citrate effervescent tablet and preparation method thereof |
-
2015
- 2015-10-08 CN CN201510649024.4A patent/CN105213360B/en active Active
Non-Patent Citations (2)
| Title |
|---|
| 枸橼酸碘溶液对大肠杆菌杀菌效果试验观察;刘肖娟等;《兽医导刊》;20150531;第10卷(第53期);53 * |
| 氨基酸碘对白色念珠菌的杀菌机理研究;熊鸿燕等;《中国消毒学杂志》;20071231;第24卷(第4期);310-313 * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110974815A (en) * | 2019-12-18 | 2020-04-10 | 佛山市正典生物技术有限公司 | Iodine citrate effervescent tablet and preparation method thereof |
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