CN105194503A - A traditional Chinese medicine oral liquid for treating chronic urethritis and its preparation method - Google Patents

Abstract

The invention discloses a traditional Chinese medicine oral liquid for treating chronic urethritis and a preparation method thereof, wherein the traditional Chinese medicine oral liquid is prepared from the following raw materials in parts by weight: 38-42 parts of longhairy antenoron herb, 18-22 parts of yam rhizome, 28-32 parts of dahurian patrinia herb, 18-22 parts of amur corktree bark, 13-17 parts of epimedium herb, 13-17 parts of raspberry, 18-22 parts of sharpleaf galangal fruit, 18-22 parts of gorgon fruit, 28-32 parts of Chinese yam, 18-22 parts of oriental waterplantain rhizome, 18-22 parts of cherokee rose fruit, 8-12 parts of lotus stamen, 18-22 parts of cuttlebone and 4-8 parts of liquorice. The traditional Chinese medicine composition has the effects of warming and recuperating kidney yang, clearing heat and removing dampness, and is a safe and reliable traditional Chinese medicine composition without any toxic or side effect, high utilization rate of effective components and quick response.

Description

A traditional Chinese medicine oral liquid for treating chronic urethritis and its preparation method

technical field

The invention relates to a traditional Chinese medicine oral liquid for treating chronic urethritis, which belongs to the field of traditional Chinese medicines.

Background technique

Chronic urethritis can occur in both men and women, and men often have prostatitis at the same time; women have a short urethra, and germs are more likely to invade. This disease is a common disease and frequently-occurring disease. It is a chronic process, and the common symptoms after getting sick are urethral discomfort, burning, and itching. Some have a small amount of clear discharge, frequent urination, increased nocturia, lower abdominal discomfort, and pubic pain. Men still have symptoms of discomfort in the scrotum and testicles. Symptoms Chronic urethritis manifests as frequent urination, urgency, and painful urination. The bacterial culture of VB1 is positive, while the bacterial culture of VB3 and EPS has no bacterial growth. Chronic urethritis is difficult to cure completely. The main reason is that some people have acute After urethritis, anti-inflammatory drugs are used indiscriminately outside. After taking it, it is ineffective or the condition is temporarily controlled. Relapse after drinking alcohol or eating seafood and other irritants, often brings double burdens to the patient's economy and spirit. The symptoms of chronic urethritis are not as acute as those of acute urethritis. Inflammation is so obvious, urethral secretions decrease, only itching or ants feeling, micturition stimulation is not as obvious as in the acute stage, some patients may be asymptomatic, urethral burning pain, frequent urination, urgency, and even dysuria during urination. The main method of western medicine treatment for this disease is to take antibiotics, but most of the western medicine treatment is to temporarily control the disease, and taking too many antibiotics is harmful to the human body, because the abuse of antibiotics may lead to the imbalance of normal flora in the throat and lead to bacterial resistance Strengthening, the immune function of the human body is weakened, resulting in repeated and difficult to heal the disease.

Contents of the invention

Aiming at the deficiencies in the prior art, the object of the present invention is to provide a traditional Chinese medicine oral liquid for treating chronic urethritis, which has the effects of warming and tonifying kidney yang, clearing away heat and strengthening dampness.

The present invention is achieved through the following technical solutions:

A traditional Chinese medicine oral liquid for treating chronic urethritis, which is made of the following raw materials in parts by weight: 38-42 parts of Desmodium chinensis, 18-22 parts of Rhizoma chinensis, 28-32 parts of Patrinia, 18-22 parts of Phellodendron Phellodendri, 13 parts of Epimedium -17 parts, 13-17 parts of raspberry, 18-22 parts of Yizhi kernel, 18-22 parts of gorgon, 28-32 parts of yam, 18-22 parts of Alisma, 18-22 parts of golden cherry, 8- 12 parts, sea octopus 18-22 parts, licorice 4-8 parts.

Preferably, the parts by weight of each raw material are: 40 parts of Desmodium chinensis, 20 parts of Gorgon, 30 parts of Patrinia, 20 parts of Cortex Phellodendri, 15 parts of Epimedium, 15 parts of Raspberry, 20 parts of Yizhiren, 20 parts of Gorgon, Chinese yam 30 parts, 20 parts of Alisma, 20 parts of golden cherry, 10 parts of lotus root, 20 parts of squid octopus, 6 parts of licorice.

Pharmacological effects:

Money grass: nature, flavor and meridian distribution: sweet, salty, slightly cold; returns to liver, gallbladder, kidney, bladder meridian, function and indications: clearing away dampness and heat, clearing stranguria, detumescence; used for hot shower, sandy shower, astringent urine Pain, jaundice, red urine, carbuncle and furuncle, poisonous snake bites; liver and gallstones, urinary tract stones.

Bixie: bitter in nature and flavor, flat; return to the meridian: return to the kidney and stomach meridian; effect of promoting dampness and removing turbidity, expelling wind and eliminating numbness; mainly used for ointment stranguria, white turbidity, excessive leucorrhea, rheumatism arthralgia, joint dysmenorrhea, waist and knee pain.

Patrinia: meridian distribution of property and flavor: pungent, bitter, slightly cold; return stomach, large intestine, liver channel; effect: heat-clearing and toxic substances removing, carbuncle and pus discharge, blood stasis and pain relief; function cures mainly: heat-clearing and toxic substances removing, blood stasis and pus discharge; Appendicitis, dysentery, enteritis, hepatitis, conjunctivitis, postpartum blood stasis, abdominal pain, carbuncle and furuncle.

Phellodendron Phellodendri: Nature, flavor and meridians: bitter, cold; returns kidney, bladder meridian, functions and indications: clearing away heat and dampness, purging fire and removing steam, detoxifying and treating sores; used for damp-heat diarrhea, jaundice, leukorrhea, hot stranguria, beriberi , flaccidity, bone steam labor heat, night sweats, nocturnal emission, sore swelling, eczema itching;

Epimedium: nature, flavor and meridian distribution: pungent, sweet, warm; returns to liver, kidney meridian, function and indications: nourishing kidney yang, strengthening bones and muscles, dispelling rheumatism; used for impotence and nocturnal emission, weakness of muscles and bones, arthralgia due to rheumatism, numbness and spasm ; Menopausal hypertension.

Raspberry: property, flavor and meridian distribution: sweet, sour, warm; returns to kidney and bladder meridians, functions and indications: nourishing kidney, strengthening essence, reducing urination; used for enuresis due to kidney deficiency, frequent urination, impotence and premature ejaculation, spermatorrhea and spermatorrhea.

Yizhiren: nature, flavor and meridian distribution: pungent, warm; return to the spleen and kidney meridians, functions and indications: warming the spleen to stop diarrhea, taking in saliva, warming the kidney, consolidating essence and reducing urination; used for spleen-cold diarrhea, abdominal Cold pain, excessive salivation, enuresis due to kidney deficiency, frequent urination, white turbid spermatorrhea.

Gorgon fruit: nature, flavor and meridians: sweet, astringent, flat; returns to spleen and kidney meridians, functions and indications: nourishing kidney and strengthening essence, nourishing spleen and stopping diarrhea, dispelling dampness and stopping belt; used for nocturnal emission, enuresis, frequent urination, chronic diarrhea due to spleen deficiency , cloudy, leukorrhagia.

Chinese yam: nature, flavor and meridian distribution: sweet, flat; returns to spleen, lung, kidney meridian, function and indications: nourishing spleen and stomach, promoting body fluid and benefiting lung, tonifying kidney and astringent essence; used for deficiency of the spleen, lack of food, persistent diarrhea, asthma due to lung deficiency Cough, kidney deficiency, spermatorrhea, leucorrhea, frequent urination, deficiency heat and thirst; bran-fried yam nourishes the spleen and stomach; used for spleen deficiency, diarrhea, loose stool, and excessive leucorrhea.

Alisma: property, flavor and meridians: sweet, cold; returns kidney, bladder meridian, function and indications: diuresis, clearing damp and heat; used for dysuria, edema, oliguria, dizziness due to phlegm and retention, hot dripping and astringent pain; hyperlipidemia.

Fructus Rosa Rosa: Nature, flavor and meridians: sour, sweet, astringent, flat; returns to kidney, bladder, and large intestine meridians, functions and indications: solidifying essence and reducing urination, astringent intestines to stop diarrhea; used for spermatorrhea, enuresis, frequent urination, metrorrhagia Leukorrhagia, chronic diarrhea and dysentery.

Lianxu: nature, flavor and meridian distribution: sweet, astringent, flat; heart-guiding, kidney meridian, functions and indications: solidifying kidney and astringent essence; used for spermatorrhea, leucorrhea, and frequent urination.

Seaweed octopus: nature, flavor and meridian distribution: salty, astringent, warm; return to spleen, kidney meridian, function and indications: astringent to stop bleeding, astringent essence to stop belt, antacid, sore; used for stomachache, acid regurgitation, vomiting blood and epistaxis, Metrorrhagia and hematochezia, spermatorrhea and spermatorrhea, red and white vaginal discharge; ulcer disease; external treatment of injury and bleeding, sores with pus.

Licorice root: nature, flavor and meridians: sweet, flat; Guixin, lung, spleen, stomach meridians, functions and indications: invigorating the spleen and replenishing qi, clearing heat and detoxification, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing various medicines; used for weak spleen and stomach, fatigue Fatigue, palpitations, shortness of breath, cough with excess phlegm, abdominal pain, acute pain in the limbs, carbuncle sores, relieve drug toxicity and potency.

Another technical problem to be solved by the present invention is to provide a preparation method for the above-mentioned traditional Chinese medicine oral liquid.

Another technical problem to be solved by the present invention is achieved through the following technical solutions:

A preparation method of a traditional Chinese medicine oral liquid for the treatment of chronic urethritis, prepared by the following method:

(1) Take the raw materials Desmodium syringa, Patrinia, Phellodendron Phellodendri, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosaceae, and Licorice, wash and dry, and grind the dried raw materials with a pulverizer while they are hot. 30-50 mesh sieve, spare;

(2) Take the raw materials Gorgon fruit, yam, Alisma, and lotus root, wash them, dry them, crush the dried raw materials with a grinder while they are hot, pass them through a 30-50 mesh sieve, and set aside;

(3) Clean the sea slug octopus as raw material, dry it, pulverize the dried raw material with a pulverizer while it is hot, pass through a 30-50 mesh sieve, and set aside;

(4) Add Desmodium, Patrinia, Cortex Phellodendron, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosa Rosa, and Licorice crushed in step (1) to the weight of the above raw materials and 8-13 times the water , decocting for 1-3 hours, release the medicinal liquid; add the weight of the above raw materials and 6-12 times the water to decoct the crushed Gorgon fruit, yam, Alisma, and lotus root in step (2) for 2-3 hours, and release the medicinal liquid liquid; add 6-12 times the weight of the above raw materials to decoct the pulverized sea octopus in step (3) for 2-3 hours, and release the medicinal liquid; add 6-8 times the weight of the decoction Boil for 1.5-2.5 hours to release the medicinal liquid; combine the medicinal liquids decocted four times, filter, discard the medicinal residues, and obtain the filtrate for later use;

(5) Add the filtrate obtained in step (4) to 95% ethanol that is 1.5-2 times the weight of the filtrate, stir evenly and let it stand for 20-24 hours, precipitate, recover the ethanol, then filter through a centrifugal filter, collect the filtrate, and send the filtrate to Filtrate in a plate filter, the filter membrane pore size range of the plate filter is 0.8-2 μm, the pressure range is 0.15-0.3MPa during the filtration process, and the water flow rate on the membrane surface is 0.8-1.5T/h to obtain the filtrate ,spare;

(6) Send the filtrate obtained in step (5) into a plate filter for filtration. The filter membrane pore size range of the plate filter is 0.6-0.8 μm, and the pressure range is 0.15-0.3 MPa during the filtration process. The surface water flow rate is 0.8-1.5T/h, and the filtrate is obtained for use;

(7) Send the filtrate obtained in step (6) into a traditional Chinese medicine concentrator, concentrate it under reduced pressure in the concentrator to a clear ointment with a relative density of 1.01-1.05 at 50-60°C, and obtain a clear ointment for later use;

(8) Let the clear paste obtained in step (7) stand at 5-6°C for 24-36 hours, adjust the pH value to 6.0-8.0 with sodium hydroxide solution, filter, and seal the filtrate in a bottle. Sterilize with ultraviolet rays, sterilize and irradiate for 20-30 minutes with ultraviolet wavelengths of 240nm-270nm, and pack to obtain a finished product, which is a traditional Chinese medicine oral liquid for treating chronic urethritis.

Preferably, a preparation method of a traditional Chinese medicine oral liquid for the treatment of chronic urethritis is prepared by the following method:

(1) Take the raw materials Desmodium syringa, Patrinia, Phellodendron Phellodendri, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosaceae, and Licorice, wash and dry, and grind the dried raw materials with a pulverizer while they are hot. 30 mesh sieve, spare;

(2) Take the raw materials Gorgon fruit, yam, Alisma, and lotus root, wash them, dry them, crush them with a pulverizer while they are hot, pass them through a 30-mesh sieve, and set aside;

(3) Clean the sea slug octopus as the raw material, dry it, pulverize the dried raw material with a pulverizer while it is hot, pass it through a 30-mesh sieve, and set aside;

(4) Add Desmodium, Patrinia, Cork Phellodendron, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosa Rosa, and Licorice crushed in step (1) to the weight of the above ingredients and 13 times the water, and fry Boil for 1.5 hours to release the medicinal liquid; add the Gorgon fruit, yam, Alisma, and lotus root crushed in step (2) to the weight of the above raw materials and 12 times the water and decoct for 2 hours to release the medicinal liquid; Add water 12 times the weight of the above raw materials to decoct the pulverized sea octopus for 2 hours to release the medicinal liquid; add the dregs of three times the weight and add water 8 times the weight to decoct for 1.5 hours to release the medicinal liquid; combine the decocted four times The liquid medicine is filtered, and the medicine residue is discarded to obtain the filtrate for subsequent use;

(5) Add the filtrate obtained in step (4) to 95% ethanol that is 1.5 times the weight of the filtrate, stir evenly and let it stand for 20 hours, precipitate, recover ethanol, filter through a centrifugal filter, collect the filtrate, and then send the filtrate to a plate filter Filtrate in, the filter membrane pore diameter of described plate filter is 0.8 μ m, the pressure range is 0.15MPa in the process of filtration, the membrane surface water flow rate is 1.5T/h, obtain filtrate, standby;

(6) Send the filtrate obtained in step (5) into a plate filter for filtration. The filter membrane pore size of the plate filter is 0.8 μm, the pressure range during the filtration is 0.15 MPa, and the water flow rate on the membrane surface is 0.8 T/h, the filtrate was obtained for subsequent use;

(7) Send the filtrate obtained in step (6) into a traditional Chinese medicine concentrator, and concentrate it under reduced pressure in the concentrator to a clear paste with a relative density of 1.05 at 60°C to obtain a clear paste for future use;

(8) Let the clear paste obtained in step (7) stand at 6°C for 24 hours, adjust the pH value to 6.5 with sodium hydroxide solution, filter, fill the filtrate into a bottle, and sterilize with ultraviolet light. Sterilize and irradiate with a wavelength of 255nm for 30 minutes, and pack to obtain a finished product, which is a traditional Chinese medicine oral liquid for treating chronic urethritis.

Beneficial effects: the invention has the functions of warming and nourishing kidney yang, clearing away heat and strengthening dampness, and is a safe and reliable traditional Chinese medicine composition without any toxic and side effects, high utilization rate of active ingredients and quick effect.

The present invention adopts pure traditional Chinese medicine as raw material, and according to the pathogenesis and clinical features of chronic urethritis, the prescription is prepared under the guidance of the theory of traditional Chinese medicine on the basis of not the activity of raw materials. It has definite curative effect and is an ideal medicine for treating patients with chronic urethritis.

Typical cases

Case 1: Mr. Shen, 26 years old, medical history: frequent urination, urgent urination, has been in the hospital for nearly a month, and has not improved after a few days of infusion in the hospital. Appropriate: while damp-heat should be controlled, warming and invigorating kidney yang should be used to cure astringent simultaneously. The diagnosis is: chronic urethritis. Take the medicine of the present invention for treatment for 4 days. The basic symptoms disappeared, and there was no recurrence in the one-year follow-up.

Case 2: Mr. Deng, 34 years old, medical history: frequent urination, urgency, stinging and burning sensation when urinating, urethral itching, now transferred to traditional Chinese medicine for treatment, Chinese medicine believes that the syndrome belongs to the loss of lower yuan, and the infection of urethritis, suitable treatment: damp heat should be treated Simultaneously, warming and invigorating kidney-YANG are needed, and astringent and astringent are treated at the same time. Examination is: chronic urethritis. Take the medicine of the present invention for 4 days, and the patient's subjective symptoms obviously alleviate after treatment. One year without recurrence.

Case 3: Ms. Qi, 25 years old, had symptoms of frequent urination and urgency at the initial stage of the disease, and as the disease progressed, dysuria occurred, accompanied by low back pain and fever symptoms, diagnosed as: chronic urethritis, and took the drug of the present invention for 4 days After treatment, the patient's subjective symptoms obviously alleviated. After taking the medicine of the present invention for two courses of treatment, the patient's above-mentioned basic symptoms disappeared, took three courses of treatment and recovered, and followed up a case by regular visits to 1 year without recurrence.

Case 4: Mr. An, 35 years old, medical history: urethral mouth redness, swelling and itching, burning pain during urination, diagnosed as: chronic urethritis, took the medicine of the present invention for 4 days, and the patient's subjective symptoms were obviously alleviated after treatment. After a course of treatment, the above-mentioned basic symptoms of the patient disappeared, and there was no recurrence in the one-year follow-up.

Case 5: Mr. Yang, 30 years old, medical history: the patient began to have urethra burning, pain sensation one month ago, a small amount of viscous secretion at the opening of the urethra in the morning, and was diagnosed as: chronic urethritis. After the patient's subjective symptoms obviously alleviated, after taking the medicine of the present invention for two courses for the treatment of, the above-mentioned basic symptoms of the patient disappeared, followed up a case by regular visits to without recurrence in 1 year.

Case 6: Mr. Song, 45 years old, medical history: the patient had frequent urination, accompanied by dysuria, and had the desire to defecate just after urinating, dripping endlessly. The diagnosis was: chronic urethritis. He took the medicine of the present invention for 4 days. After treatment, the patient Subjective symptom obviously alleviates, and patient's above-mentioned basic symptom disappears after taking medicine of the present invention for two courses of treatment, follows up a case by regular visits to and has no recurrence in 1 year.

clinical information:

General information: A total of 50 patients were treated, including 29 males and 21 females, aged 25-60 years.

Diagnostic criteria: 1) history of unclean sexual contact; 2) incubation period 1-3 weeks; 3) common clinical manifestations: male patients often have serous or mucopurulent discharge from the urethral opening or painful urination. Female patients often have frequent urination and dysuria. For example, when the cervix is involved, it manifests as inflammation and erosion, increased secretions, vaginal and external itching, but some patients are asymptomatic; 4) Complications: the main complications in men are epididymitis, prostatitis and Reiter syndrome; Women mainly suffer from salpingitis, pelvic inflammatory disease, ectopic pregnancy and infertility, etc.; 5) The secretion smear and cultured gonorrhea are all negative, while the smear microscopic examination shows that the polymorphonuclear leukocytes exceed 4 cells or morning urine, 15 ml of precipitation in the first segment of urine, under a 400-fold field of view, more than 15 polymorphonuclear leukocytes per field of view.

Therapeutic method: take oral liquid of the present invention, every day 2 times, each 30ml, 7 days a course of treatment, during taking medicine, forbid to eat raw, cold, hot, the food that stimulates the stomach.

Criteria for judging the curative effect: cured: the symptoms disappeared and returned to normal; effective: the pain was relieved; ineffective: the clinical symptoms were not significantly improved.

Treatment results: 50 cases of chronic urethritis were treated with this prescription, of which 40 cases were clinically cured, 10 cases were effective, and 0 cases were ineffective, and the effective rate was 100%.

Detailed ways

Example 1

The preparation of the traditional Chinese medicine oral liquid for treating chronic urethritis of the present invention, the parts by weight of each raw material are: 42 parts of Desmodium, 22 parts of Patrinia, 22 parts of Cortex Phellodendri, 17 parts of Epimedium, 17 parts of Raspberry, 22 parts of Zhiren, 22 parts of Gorgon, 32 parts of Chinese yam, 22 parts of Alisma, 22 parts of golden cherry, 12 parts of lotus root, 22 parts of sea octopus, 8 parts of licorice;

Prepared by:

(1) Take the raw materials Desmodium syringa, Patrinia, Phellodendron Phellodendri, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosaceae, and Licorice, wash and dry, and grind the dried raw materials with a pulverizer while they are hot. 30-50 mesh sieve, spare;

(2) Take the raw materials Gorgon fruit, yam, Alisma, and lotus root, wash them, dry them, crush the dried raw materials with a grinder while they are hot, pass them through a 30-50 mesh sieve, and set aside;

(3) Clean the sea slug octopus as raw material, dry it, pulverize the dried raw material with a pulverizer while it is hot, pass through a 30-50 mesh sieve, and set aside;

(4) Add Desmodium, Patrinia, Cortex Phellodendron, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosa Rosa, and Licorice crushed in step (1) to the weight of the above raw materials and 8-13 times the water , decocting for 1-3 hours, release the medicinal liquid; add the weight of the above raw materials and 6-12 times the water to decoct the crushed Gorgon fruit, yam, Alisma, and lotus root in step (2) for 2-3 hours, and release the medicinal liquid liquid; add 6-12 times the weight of the above raw materials to decoct the pulverized sea octopus in step (3) for 2-3 hours, and release the medicinal liquid; add 6-8 times the weight of the decoction Boil for 1.5-2.5 hours to release the medicinal liquid; combine the medicinal liquids decocted four times, filter, discard the medicinal residues, and obtain the filtrate for later use;

(5) Add the filtrate obtained in step (4) to 95% ethanol that is 1.5-2 times the weight of the filtrate, stir evenly and let it stand for 20-24 hours, precipitate, recover the ethanol, then filter through a centrifugal filter, collect the filtrate, and send the filtrate to Filtrate in a plate filter, the filter membrane pore size range of the plate filter is 0.8-2 μm, the pressure range is 0.15-0.3MPa during the filtration process, and the water flow rate on the membrane surface is 0.8-1.5T/h to obtain the filtrate ,spare;

(6) Send the filtrate obtained in step (5) into a plate filter for filtration. The filter membrane pore size range of the plate filter is 0.6-0.8 μm, and the pressure range is 0.15-0.3 MPa during the filtration process. The surface water flow rate is 0.8-1.5T/h, and the filtrate is obtained for use;

(7) Send the filtrate obtained in step (6) into a traditional Chinese medicine concentrator, concentrate it under reduced pressure in the concentrator to a clear ointment with a relative density of 1.01-1.05 at 50-60°C, and obtain a clear ointment for later use;

(8) Let the clear paste obtained in step (7) stand at 5-6°C for 24-36 hours, adjust the pH value to 6.0-8.0 with sodium hydroxide solution, filter, and seal the filtrate in a bottle. Sterilize with ultraviolet rays, sterilize and irradiate for 20-30 minutes with ultraviolet wavelengths of 240nm-270nm, and pack to obtain a finished product, which is a traditional Chinese medicine oral liquid for treating chronic urethritis.

Usage: Take orally, 2 times a day, 30ml each time.

Example 2

The preparation of the traditional Chinese medicine oral liquid for treating chronic urethritis of the present invention, the parts by weight of each raw material are: 40 parts of Desmodium, 20 parts of Patrinia, 20 parts of Cortex Phellodendri, 15 parts of Epimedium, 15 parts of Raspberry, 20 parts of Zhiren, 20 parts of Gorgon, 30 parts of Chinese yam, 20 parts of Alisma, 20 parts of golden cherry, 10 parts of lotus root, 20 parts of sea octopus, 6 parts of licorice;

Prepared by:

(1) Take the raw materials Desmodium syringa, Patrinia, Phellodendron Phellodendri, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosaceae, and Licorice, wash and dry, and grind the dried raw materials with a pulverizer while they are hot. 30-50 mesh sieve, spare;

(2) Take the raw materials Gorgon fruit, yam, Alisma, and lotus root, wash them, dry them, crush the dried raw materials with a grinder while they are hot, pass them through a 30-50 mesh sieve, and set aside;

(3) Clean the sea slug octopus as raw material, dry it, pulverize the dried raw material with a pulverizer while it is hot, pass through a 30-50 mesh sieve, and set aside;

(4) Add Desmodium, Patrinia, Cortex Phellodendron, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosa Rosa, and Licorice crushed in step (1) to the weight of the above raw materials and 8-13 times the water , decocting for 1-3 hours, release the medicinal liquid; add the weight of the above raw materials and 6-12 times the water to decoct the crushed Gorgon fruit, yam, Alisma, and lotus root in step (2) for 2-3 hours, and release the medicinal liquid liquid; add 6-12 times the weight of the above raw materials to decoct the pulverized sea octopus in step (3) for 2-3 hours, and release the medicinal liquid; add 6-8 times the weight of the decoction Boil for 1.5-2.5 hours to release the medicinal liquid; combine the medicinal liquids decocted four times, filter, discard the medicinal residues, and obtain the filtrate for later use;

(5) Add the filtrate obtained in step (4) to 95% ethanol that is 1.5-2 times the weight of the filtrate, stir evenly and let it stand for 20-24 hours, precipitate, recover the ethanol, then filter through a centrifugal filter, collect the filtrate, and send the filtrate to Filtrate in a plate filter, the filter membrane pore size range of the plate filter is 0.8-2 μm, the pressure range is 0.15-0.3MPa during the filtration process, and the water flow rate on the membrane surface is 0.8-1.5T/h to obtain the filtrate ,spare;

(6) Send the filtrate obtained in step (5) into a plate filter for filtration. The filter membrane pore size range of the plate filter is 0.6-0.8 μm, and the pressure range is 0.15-0.3 MPa during the filtration process. The surface water flow rate is 0.8-1.5T/h, and the filtrate is obtained for use;

(7) Send the filtrate obtained in step (6) into a traditional Chinese medicine concentrator, concentrate it under reduced pressure in the concentrator to a clear ointment with a relative density of 1.01-1.05 at 50-60°C, and obtain a clear ointment for later use;

(8) Let the clear paste obtained in step (7) stand at 5-6°C for 24-36 hours, adjust the pH value to 6.0-8.0 with sodium hydroxide solution, filter, and seal the filtrate in a bottle. Sterilize with ultraviolet rays, sterilize and irradiate for 20-30 minutes with ultraviolet wavelengths of 240nm-270nm, and pack to obtain a finished product, which is a traditional Chinese medicine oral liquid for treating chronic urethritis.

Usage: Take orally, 2 times a day, 30ml each time.

Example 3

The preparation of the traditional Chinese medicine oral liquid for treating chronic urethritis of the present invention, the parts by weight of each raw material are: 38 parts of Desmodium, 18 parts of Patrinia, 18 parts of Cortex Phellodendri, 13 parts of Epimedium, 13 parts of Raspberry, 18 parts of Zhiren, 18 parts of Gorgon, 28 parts of Chinese yam, 18 parts of Alisma, 18 parts of golden cherry, 8 parts of lotus root, 18 parts of sea octopus, 4 parts of licorice;

Prepared by:

(1) Take the raw materials Desmodium syringa, Patrinia, Phellodendron Phellodendri, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosaceae, and Licorice, wash and dry, and grind the dried raw materials with a pulverizer while they are hot. 30-50 mesh sieve, spare;

(2) Take the raw materials Gorgon fruit, yam, Alisma, and lotus root, wash them, dry them, crush the dried raw materials with a grinder while they are hot, pass them through a 30-50 mesh sieve, and set aside;

(3) Clean the sea slug octopus as raw material, dry it, pulverize the dried raw material with a pulverizer while it is hot, pass through a 30-50 mesh sieve, and set aside;

(4) Add Desmodium, Patrinia, Cortex Phellodendron, Epimedium, Raspberry, Lemongrass, Yizhiren, Rosa Rosa, and Licorice crushed in step (1) to the weight of the above raw materials and 8-13 times the water , decocting for 1-3 hours, release the medicinal liquid; add the weight of the above raw materials and 6-12 times the water to decoct the crushed Gorgon fruit, yam, Alisma, and lotus root in step (2) for 2-3 hours, and release the medicinal liquid liquid; add 6-12 times the weight of the above raw materials to decoct the pulverized sea octopus in step (3) for 2-3 hours, and release the medicinal liquid; add 6-8 times the weight of the decoction Boil for 1.5-2.5 hours to release the medicinal liquid; combine the medicinal liquids decocted four times, filter, discard the medicinal residues, and obtain the filtrate for later use;

(5) Add the filtrate obtained in step (4) to 95% ethanol that is 1.5-2 times the weight of the filtrate, stir evenly and let it stand for 20-24 hours, precipitate, recover the ethanol, then filter through a centrifugal filter, collect the filtrate, and send the filtrate to Filtrate in a plate filter, the filter membrane pore size range of the plate filter is 0.8-2 μm, the pressure range is 0.15-0.3MPa during the filtration process, and the water flow rate on the membrane surface is 0.8-1.5T/h to obtain the filtrate ,spare;

(6) Send the filtrate obtained in step (5) into a plate filter for filtration. The filter membrane pore size range of the plate filter is 0.6-0.8 μm, and the pressure range is 0.15-0.3 MPa during the filtration process. The surface water flow rate is 0.8-1.5T/h, and the filtrate is obtained for use;

(7) Send the filtrate obtained in step (6) into a traditional Chinese medicine concentrator, concentrate it under reduced pressure in the concentrator to a clear ointment with a relative density of 1.01-1.05 at 50-60°C, and obtain a clear ointment for later use;

(8) Let the clear paste obtained in step (7) stand at 5-6°C for 24-36 hours, adjust the pH value to 6.0-8.0 with sodium hydroxide solution, filter, and seal the filtrate in a bottle. Sterilize with ultraviolet rays, sterilize and irradiate for 20-30 minutes with ultraviolet wavelengths of 240nm-270nm, and pack to obtain a finished product, which is a traditional Chinese medicine oral liquid for treating chronic urethritis.

Usage: Take orally, 2 times a day, 30ml each time.

Claims (6)

1. treat a Chinese medicine oral liquid for chronic urethritis, it is characterized in that: be made up of following raw material: Herba Lysimachiae 38-42 part, Rhizoma Dioscoreae Septemlobae 18-22 part, Herba Patriniae 28-32 part, Cortex Phellodendri 18-22 part, Herba Epimedii 13-17 part, Fructus Rubi 13-17 part, Fructus Alpiniae Oxyphyllae 18-22 part, Semen Euryales 18-22 part, Rhizoma Dioscoreae 28-32 part, Rhizoma Alismatis 18-22 part, Fructus Rosae Laevigatae 18-22 part, Stamen Nelumbinis 8-12 part, Endoconcha Sepiae 18-22 part, Radix Glycyrrhizae 4-8 part.

2. a kind of Chinese medicine oral liquid for the treatment of chronic urethritis according to claim 1, is characterized in that: the weight portion of each raw material is: Herba Lysimachiae 40 parts of, Rhizoma Dioscoreae Septemlobae 20 parts, Herba Patriniae 30 parts, Cortex Phellodendri 20 parts, Herba Epimedii 15 parts, Fructus Rubi 15 parts, Fructus Alpiniae Oxyphyllae 20 parts, Semen Euryales 20 parts, Rhizoma Dioscoreae 30 parts, Rhizoma Alismatis 20 parts, Fructus Rosae Laevigatae 20 parts, Stamen Nelumbinis 10 parts, Endoconcha Sepiae 20 parts, 6 parts, Radix Glycyrrhizae.

3. a kind of Chinese medicine oral liquid for the treatment of chronic urethritis according to claim 1, is characterized in that: the weight portion of each raw material is: Herba Lysimachiae 42 parts of, Rhizoma Dioscoreae Septemlobae 22 parts, Herba Patriniae 32 parts, Cortex Phellodendri 22 parts, Herba Epimedii 17 parts, Fructus Rubi 17 parts, Fructus Alpiniae Oxyphyllae 22 parts, Semen Euryales 22 parts, Rhizoma Dioscoreae 32 parts, Rhizoma Alismatis 22 parts, Fructus Rosae Laevigatae 22 parts, Stamen Nelumbinis 12 parts, Endoconcha Sepiae 22 parts, 8 parts, Radix Glycyrrhizae.

4. a kind of Chinese medicine oral liquid for the treatment of chronic urethritis according to claim 1, is characterized in that: the weight portion of each raw material is: Herba Lysimachiae 38 parts of, Rhizoma Dioscoreae Septemlobae 18 parts, Herba Patriniae 28 parts, Cortex Phellodendri 18 parts, Herba Epimedii 13 parts, Fructus Rubi 13 parts, Fructus Alpiniae Oxyphyllae 18 parts, Semen Euryales 18 parts, Rhizoma Dioscoreae 28 parts, Rhizoma Alismatis 18 parts, Fructus Rosae Laevigatae 18 parts, Stamen Nelumbinis 8 parts, Endoconcha Sepiae 18 parts, 4 parts, Radix Glycyrrhizae.

5. a kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic urethritis according to claim 1 and 2, is characterized in that: be prepared from by following methods:

(1) get raw material Herba Lysimachiae, Herba Patriniae, Cortex Phellodendri, Herba Epimedii, Fructus Rubi, Rhizoma Dioscoreae Septemlobae, Fructus Alpiniae Oxyphyllae, Fructus Rosae Laevigatae, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(2) get raw material Semen Euryales, Rhizoma Dioscoreae, Rhizoma Alismatis, Stamen Nelumbinis cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(3) get the cleaning of raw material Endoconcha Sepiae, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30-50 mesh sieve, for subsequent use;

(4) Herba Lysimachiae after pulverizing in step (1), Herba Patriniae, Cortex Phellodendri, Herba Epimedii, Fructus Rubi, Rhizoma Dioscoreae Septemlobae, Fructus Alpiniae Oxyphyllae, Fructus Rosae Laevigatae, Radix Glycyrrhizae are added above-mentioned raw materials weight and 8-13 water doubly, decoct 1-3 hour, release medicinal liquid; Semen Euryales after pulverizing in step (2), Rhizoma Dioscoreae, Rhizoma Alismatis, Stamen Nelumbinis are added above-mentioned raw materials weight and 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Endoconcha Sepiae after pulverizing in step (3) is added above-mentioned raw materials weight 6-12 soak by water 2-3 hour doubly, releases medicinal liquid; Add its weight 6-8 soak by water 1.5-2.5 hour doubly after three times medicinal residues merge, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(5) gained filtrate in step (4) is added the ethanol of filtrate weight 1.5-2 times 95%, leave standstill 20-24h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane pore diameter range of described leaf filter is 0.8-2 μm, in the process of filtering, pressure limit is 0.15-0.3MPa, face discharge is 0.8-1.5T/h, obtains filtrate, for subsequent use;

(6) filter in step (5) in gained filtrate feeding leaf filter, the filter membrane pore diameter range of described leaf filter is 0.6-0.8 μm, and in the process of filtering, pressure limit is 0.15-0.3MPa, and face discharge is 0.8-1.5T/h, obtain filtrate, for subsequent use;

(7) gained filtrate in step (6) is sent into traditional Chinese drug inspissation machine, in thickener, be evaporated to the clear paste of relative density 1.01-1.05 during 50-60 DEG C, obtain clear paste, for subsequent use;

(8) gained clear paste in step (7) is statically placed in 24-36 hour under the condition of 5-6 DEG C, by sodium hydroxide solution adjust ph to 6.0-8.0, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 20-30min is irradiated in ultraviolet wavelength 240nm-270nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of chronic urethritis.

6. a kind of preparation method for the treatment of the Chinese medicine oral liquid of chronic urethritis according to claim 1 and 2, is characterized in that: be prepared from by following methods:

(1) get raw material Herba Lysimachiae, Herba Patriniae, Cortex Phellodendri, Herba Epimedii, Fructus Rubi, Rhizoma Dioscoreae Septemlobae, Fructus Alpiniae Oxyphyllae, Fructus Rosae Laevigatae, Radix Glycyrrhizae cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(2) get raw material Semen Euryales, Rhizoma Dioscoreae, Rhizoma Alismatis, Stamen Nelumbinis cleaning, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(3) get the cleaning of raw material Endoconcha Sepiae, dry, the raw material of drying is pulverized with pulverizer while hot, crosses 30 mesh sieves, for subsequent use;

(4) Herba Lysimachiae after pulverizing in step (1), Herba Patriniae, Cortex Phellodendri, Herba Epimedii, Fructus Rubi, Rhizoma Dioscoreae Septemlobae, Fructus Alpiniae Oxyphyllae, Fructus Rosae Laevigatae, Radix Glycyrrhizae are added the water of above-mentioned raw materials weight and 13 times, decocts 1.5 hours, releasing medicinal liquid; Semen Euryales after pulverizing in step (2), Rhizoma Dioscoreae, Rhizoma Alismatis, Stamen Nelumbinis are added the soak by water 2 hours of above-mentioned raw materials weight and 12 times, release medicinal liquid; Endoconcha Sepiae after pulverizing in step (3) is added the soak by water 2 hours of above-mentioned raw materials weight 12 times, release medicinal liquid; Three medicinal residues add the soak by water 1.5 hours of its weight 8 times after merging, release medicinal liquid; Merge the medicinal liquid decocted for four times, filter, abandon medicinal residues, obtain filtrate, for subsequent use;

(5) gained filtrate in step (4) is added the ethanol of 95% of filtrate weight 1.5 times, leave standstill 20h after stirring, precipitation, reclaim ethanol, filtered by centrifugal filter again, collect filtrate, filtrate is sent in leaf filter and is filtered, and the filter membrane aperture of described leaf filter is 0.8 μm, in the process of filtering, pressure limit is 0.15MPa, face discharge is 1.5T/h, obtains filtrate, for subsequent use;

(6) filter in step (5) in gained filtrate feeding leaf filter, the filter membrane aperture of described leaf filter is 0.8 μm, and in the process of filtering, pressure limit is 0.15MPa, and face discharge is 0.8T/h, obtains filtrate, for subsequent use;

(7) gained filtrate in step (6) is sent into traditional Chinese drug inspissation machine, when being evaporated to 60 DEG C in thickener, the clear paste of relative density 1.05, obtains clear paste, for subsequent use;

(8) gained clear paste in step (7) is statically placed in 24 hours under the condition of 6 DEG C, by sodium hydroxide solution adjust ph to 6.5, filter, by in filtrate embedding bottle, with ultraviolet disinfection, 30min is irradiated in ultraviolet wavelength 255nm sterilizing, packs to obtain finished product, must treat the Chinese medicine oral liquid of chronic urethritis.