CN105193645B - A kind of disinfection hand cleanser - Google Patents
A kind of disinfection hand cleanser Download PDFInfo
- Publication number
- CN105193645B CN105193645B CN201510561249.4A CN201510561249A CN105193645B CN 105193645 B CN105193645 B CN 105193645B CN 201510561249 A CN201510561249 A CN 201510561249A CN 105193645 B CN105193645 B CN 105193645B
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- Prior art keywords
- hand cleanser
- disinfection hand
- cleanser according
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- disinfection
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/347—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
- A61K8/375—Esters of carboxylic acids the alcohol moiety containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/42—Amides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/42—Colour properties
- A61K2800/43—Pigments; Dyes
- A61K2800/436—Interference pigments, e.g. Iridescent, Pearlescent
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Dermatology (AREA)
- Detergent Compositions (AREA)
- Cosmetics (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
It is as follows comprising component and mass fraction the invention provides a kind of disinfection hand cleanser：10 25 parts of surfactant；0.5 5 parts of pearlite slurry；0.1 2 parts of bactericide；35 parts of thickener；0.01 0.1 parts of preservative；0.01 1 parts of chelating agent；0.01 1 parts of pH adjusting agent.Disinfection hand cleanser provided by the invention, it is neutral non-stimulated, both there is washing and sterilizing function, there is skin moisture-keeping effect again.
Description
Technical field
The present invention relates to washing field, more particularly to a kind of disinfection hand cleanser.
Background technology
In the 1980s, hand cleanser starts to move towards family by hotel, the hotel in west, and gradually it is well known,
Thus, relatively broad popularization has worldwide been obtained.1999, " ancestral's silk " hand cleanser entered Chinese market, breaks
The blank in Chinese hand cleanser market.The development of more than ten years is have passed through, hand cleanser has become widely known, turns into people's life
Requirement.At present, the hand cleanser species of in the market is various, but it is less that really green, sterilizing function rolls into one.
The applicant applied for the patent of invention on hand cleanser, the Application No. of the patent application before
CN201310005303.8, entitled a kind of green sterilization moisture retention hand cleanser, compared to CN201310005303.8, sheet
Gentleer surfactant has been selected in invention, and with the addition of pearlite slurry, makes product more attractive in appearance, non-stimulated.Bactericide selects
With parachlorometaxylenol (PCMX), at least one of 2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers (DP-300), pass through reality
Test, for this hand cleanser to staphylococcus aureus, Escherichia coli have good fungistatic effect.
The content of the invention
Present invention aim to address subproblem present in existing hand cleanser technology, there is provided a kind of disinfection hand cleanser.
The purpose of the present invention is achieved through the following technical solutions：
A kind of disinfection hand cleanser, it is as follows comprising component and mass fraction：
Preferably, the disinfection hand cleanser includes component and mass fraction is as follows：
Preferably, the surfactant is Dodecyl Polyoxyethylene Ether sodium sulphate, Cocoamidopropyl betaine, coconut
At least one of oily diglycollic amide.
Preferably, the bactericide is to chlorine Resorcino (PCMX), 2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers (DP-
At least one of 300).
Preferably, the thickener is at least one of hydroxyethyl cellulose, hydroxypropyl methyl cellulose, sodium chloride.
Preferably, the chelating agent is at least one of ethylenediamine tetra-acetic acid, disodium edta.
Preferably, the preservative is that 1,3- dihydroxymethyls -5,5- dimethyl hydantoin (DMDMH), 2- methyl -4- are different
At least one of the ketone of thiazoline -3 (MIT), sodium benzoate.
Preferably, the pH adjusting agent is citric acid.
Preferably, the pearlite slurry is ether alcohol sulfate/EGDS/alkanolamide/glycine betaine compound.
Preferably, also containing essence or spices and deionized water.
Beneficial effects of the present invention：The hand cleanser of the application is a kind of neutral hand cleanser, and sterilization is not hurt hands, and both has washing
And sterilizing function, there is skin moisture-keeping effect again.The pearlite slurry can produce obvious pearl effect.The pearlite slurry is alcohol ether
Sulfate/EGDS/alkanolamide/glycine betaine compound, be a kind of liquid can cold scattered ethylene glycol it is hard
Resin acid crystalline esters, the pulpous state pearling agent for liquid detergent article.Ethylene glycol stearate adds in surfactant complex
Dissolve or emulsify after heat, mirror flaky crystal can be separated out in temperature-fall period, thus produce nacreous lustre.For that can be produced in hand cleanser
Obvious pearl effect, and have skin care, increase the effect such as viscosity of product, make product more attractive in appearance than common hand cleanser
With it is attractive.The bactericide can effectively suppress staphylococcus aureus and Escherichia coli.The bactericide is PCMX,
PCMX is a kind of antimildew and antibacterial agent of wide spectrum, and to most Gram-positives, negative bacterium, fungi, mould has killing effect, and it can
It is widely used in sterilization or personal-care supplies, such as anti-dandruff shampoo as antimildew and antibacterial agent, hand cleanser, soap and other health are used
In the antibacterial detergents such as product.In this hand cleanser, the amount of addition is in the range of 0.1%-2%, to staphylococcus aureus, large intestine
Bacillus has stronger bacteriostasis.In this hand cleanser, during 0.5% contents of PCMX, to staphylococcus aureus, Escherichia coli
Bacteriostasis rate is all higher than 99%.DP-300 be at present praise highly in the world wide spectrum, efficiently, almost do not have virose sterilization, bactericide.
Its stable chemical performance, heatproof, weather-proof, that acid and alkali hydrolysis, any toxicity table disease and environmental pollution do not occur, are generally acknowledged in the world
Special efficacy bactericide kind.In this hand cleanser, the amount of addition has good bacteriostasis in the range of 0.05%-2%.Its
During 0.6% content, to staphylococcus aureus, the bacteriostasis rate of big field bacillus is all higher than 99%.
Embodiment
In order to which the present invention is better described, the technical scheme in the embodiment of the present invention is clearly and completely retouched below
State.
Embodiment 1
A kind of disinfection hand cleanser, its component and its mass fraction are：
A kind of preparation method of disinfection hand cleanser of embodiment 1 is as follows：
1. sequentially add 76.1 parts of the deionized water measured, 1 part of disodium ethylene diamine tetraacetate, stir and be warming up to 60
DEG C -70 DEG C, add 8 parts of Dodecyl Polyoxyethylene Ether sodium sulphate, 6 parts of Cocoamidopropyl betaine, coconut oil diethanol acyl
3 parts of amine, stirring are allowed to dissolve.
2. being cooled to less than 30 DEG C, 2 parts of pearlite slurry is added, 0.1 part of sodium benzoate, 0.2 part of essence, 0.5 part of PCMX, is stirred
Mix and be allowed to dissolve, with 0.1 part of regulation pH ≈ 7 of citric acid, then add 3 parts of sodium chloride, stirring is allowed to dissolve.
3. packed after being filtered with 300 mesh filter screens.
Embodiment 2
A kind of green sterilization moisture retention hand cleanser, its component and its mass fraction are：
A kind of preparation method of disinfection hand cleanser of embodiment 2 is as follows：
1. sequentially add 74.52 parts of the deionized water measured, 1 part of disodium ethylene diamine tetraacetate, stir and be warming up to 60
DEG C -70 DEG C, add 5 parts of Dodecyl Polyoxyethylene Ether sodium sulphate, 10 parts of Cocoamidopropyl betaine, coconut oil diethanol acyl
2 parts of amine, stirring are allowed to dissolve.
2. being cooled to less than 30 DEG C, 3 parts of pearlite slurry, 0.1 part of DMDMH, 0.1 part of essence, DP-300 (2,4,4'- tri- are added
Chloro- 2'- dihydroxy diphenyl ethers) 0.2 part, stirring is allowed to dissolve, and with 0.08 part of regulation pH ≈ 7 of citric acid, then adds sodium chloride 4
Part, stirring is allowed to dissolve.
3. packed after being filtered with 300 mesh filter screens.
To prove the bactericidal effect of the disinfection hand cleanser of the present invention, following sterilization experiments are carried out.
1. experimental subjects
The hand cleanser that addition PCMX is the hand cleanser of bactericide and addition DP-300 is bactericide.
2. prepared by bacteria suspension
2.1 test organisms：Staphylococcus aureus ATCC6538, Escherichia coli 8099
It is prepared by 2.2 bacteria suspensions：The nutrient agar inclined-plane fresh cultured thing in the generation of strain the 5th is taken, is added with 5mL dilutions
Enter inclined-plane, wash lower lawn, and shake mixing.
3. bacteriostatic test operating procedure
3.1 will test bacteria suspension with PBS liquid dilutes, it is desirable to which concentration is:0.1mL drops are taken in control sample liquid (PBS) 5.0mL
Interior, bacterial count recovered is 1 × 104~9 × 104cfu/mL；
Test specimen is diluted to defined concentration by 3.2 with Sterile standard hard water；
3.3 absorption test specimen stostes or its dilution 5mL are put into sterilizing test tubes, 20 DEG C of constant temperature 5min；
3.4, which draw experiment bacterium solution 0.1mL, is added in the test tube of the sample containing 5mL, rapid to mix, and timing immediately；
After 3.5 effect to setting times, the mixed liquor 0.1mL of test organisms and sample is taken, is added to sterilized containing 5mL
In PBS test tube, mix；
After 3.6 place 10min, sample liquid (or after making appropriate dilution, taking the dilution of wherein 2-3 dilution factor) 1mL is drawn,
It is placed in sterilizing plates, each sample liquid or dilution are inoculated with two sterilizing plates.With cool to 40-45 DEG C of nutrient agar
(bacterium) or (sabouraud's agar saccharomycete) 15mL is poured into, and is rotated plate, is made its full and uniform, overturn after agar solidification
Plate, after (35 scholar 2) DEG C cultivates 48h (bacterium) or 72h (saccharomycete), do the counting of viable bacteria bacterium colony；
3.7 replace test specimen with PBS, while are operated by above step, as control sample；
3.8 experiments in triplicate, are averaged.
4. evaluation criterion
Bacteriostasis rate >=50%~90%, product have bacteriostasis, bacteriostasis rate >=90%, and product has stronger bacteriostasis.
5. antibacterial result
The fungistatic effect of table 1 is evaluated
As shown in Table 1, hand cleanser of the invention is all higher than 99% to the bacteriostasis rate of staphylococcus aureus and Escherichia coli,
There is good bacteriostasis.
The foregoing is only a preferred embodiment of the present invention, but protection scope of the present invention be not limited thereto,
Any one skilled in the art is in the technical scope of present disclosure, the change or replacement that can readily occur in,
It should all be included within the scope of the present invention.Therefore, protection scope of the present invention should be with the protection of claims
Scope is defined.
Claims (8)
1. a kind of disinfection hand cleanser, it is characterised in that as follows comprising component and mass fraction：
The bactericide is PCMX (parachlorometaxylenol), in DP-300 (2,4,4'- tri- chloro- 2'- dihydroxy diphenyl ethers) extremely
Few one kind；
The pearlite slurry is ether alcohol sulfate/EGDS/alkanolamide/glycine betaine compound.
2. disinfection hand cleanser according to claim 1, it is characterised in that as follows comprising component and mass fraction：
3. disinfection hand cleanser according to claim 1 or 2, it is characterised in that the surfactant is lauryl alcohol polyoxy
Ethene ether sodium sulfate, Cocoamidopropyl betaine, at least one of coconut oil diethanol amide.
4. disinfection hand cleanser according to claim 1 or 2, it is characterised in that the thickener is hydroxyethyl cellulose, hydroxyl
At least one of propyl methocel, sodium chloride.
5. disinfection hand cleanser according to claim 1 or 2, it is characterised in that the chelating agent is ethylenediamine tetra-acetic acid, second
At least one of ethylenediamine tetraacetic acid (EDTA) sodium salt.
6. disinfection hand cleanser according to claim 1 or 2, it is characterised in that the preservative is 1,3- dihydroxymethyl -5,
At least one of 5- dimethyl hydantoins (DMDMH), the ketone (MIT) of 2- methyl -4- isothiazolines -3, sodium benzoate.
7. disinfection hand cleanser according to claim 1 or 2, it is characterised in that pH adjusting agent is citric acid.
8. disinfection hand cleanser according to claim 1 or 2, it is characterised in that also containing essence or spices and deionized water.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510561249.4A CN105193645B (en) | 2015-09-06 | 2015-09-06 | A kind of disinfection hand cleanser |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510561249.4A CN105193645B (en) | 2015-09-06 | 2015-09-06 | A kind of disinfection hand cleanser |
Publications (2)
| Publication Number | Publication Date |
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| CN105193645A CN105193645A (en) | 2015-12-30 |
| CN105193645B true CN105193645B (en) | 2018-03-13 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510561249.4A Expired - Fee Related CN105193645B (en) | 2015-09-06 | 2015-09-06 | A kind of disinfection hand cleanser |
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Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309347A (en) * | 2016-08-25 | 2017-01-11 | 攀柔莎（江苏）生物科技股份有限公司 | Foaming hand washing liquid containing enzymes |
| CN106465715A (en) * | 2016-09-22 | 2017-03-01 | 长兴净安环保科技有限公司 | A kind of multi-functional bacteria-removing liquid and preparation method thereof |
| CN106479698A (en) * | 2016-09-22 | 2017-03-08 | 长兴净安环保科技有限公司 | A kind of high-efficiency multi-function bacteria-removing liquid and preparation method thereof |
| CN107280997A (en) * | 2017-06-20 | 2017-10-24 | 江苏开源康达医疗器械有限公司 | A kind of composite lysozyme sterilization ora, disinfectant and preparation method thereof |
| CN108048240A (en) * | 2017-11-27 | 2018-05-18 | 武威霖沐科技发展有限公司 | A kind of production method of feature of environmental protection Green detergent |
| CN112494366A (en) * | 2020-09-26 | 2021-03-16 | 福建省梦娇兰日用化学品有限公司 | PCMX-containing bacteriostatic hand sanitizer for children and preparation method thereof |
| CN112315894A (en) * | 2020-11-19 | 2021-02-05 | 聂绪明 | EM (effective microorganisms) hand sanitizer and preparation method thereof |
| CN113456545A (en) * | 2021-05-17 | 2021-10-01 | 江苏敖广日化集团股份有限公司 | Antibacterial hand sanitizer and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103054775A (en) * | 2013-01-07 | 2013-04-24 | 洛娃科技实业集团有限公司 | Environmentally-friendly sterilization and moisture retention hand cleanser |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5817609A (en) * | 1997-01-08 | 1998-10-06 | Lever Brothers Company, Division Of Conopco, Inc. | Bar composition comprising low viscosity oils pre-thickened by non-antifoaming hydrophobic polymers |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103054775A (en) * | 2013-01-07 | 2013-04-24 | 洛娃科技实业集团有限公司 | Environmentally-friendly sterilization and moisture retention hand cleanser |
Non-Patent Citations (3)
| Title |
|---|
| 抗菌消毒洗手液碘伏的研制与生产;罗胜铁;《洗净技术》;20040131;第2卷(第1期);第42-46页 * |
| 洗手液技术与市场;李泉清;《日用化学品科学》;20131031;第36卷(第10期);第1-3页 * |
| 高效、护肤、环保型洗手液的研制;赵娟娟 等;《科技信息》;20111231(第6期);第114-115页 * |
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| CN105193645A (en) | 2015-12-30 |
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Granted publication date: 20180313 |