CN104940490A - Hypoglycemic drug with traditional Chinese herbal medicine and active catalytic elements and preparation method of hypoglycemic drug - Google Patents
Hypoglycemic drug with traditional Chinese herbal medicine and active catalytic elements and preparation method of hypoglycemic drug Download PDFInfo
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Abstract
The invention discloses a hypoglycemic drug with Chinese herbal medicine and active catalytic elements in the field of traditional Chinese medicine and a preparation method of the hypoglycemic drug. The hypoglycemic drug comprises the effective components of rhizoma pinellinae praeparata, radix achyranthis bidentatae, glossy privet fruits, radix astragali, roots of Chinese thorowax, seeds of Chinese dodder, cinnamon, roots of red-rooted salvia, Chinese wolfberries, pulp of cornus, bitter gourd vines, roxburgh roses and wild mountain jujubes. The hypoglycemic drug can effectively reduce blood glucose and urine glucose. Aldose reductase included in the radix astragali and the roots of red-rooted salvia has a remarkable inhibition effect, can reduce sorbital aggregation and inhibit proliferation of micro vessels, and has positive significance in preventing and treating a blood vessel complication. The active catalytic elements extracted from the bitter gourd vines, the roxburgh roses, the wild mountain jujubes and the like can shorten the drug effect taking time of the drug, the effective components of the drug can be accurately, fast and directly fed to the needed portions of a human body in a centralized mode, and the concentration of the drug on the focus location is greatly increased; missing microelements of the human body are supplemented, and the microelements are automatically adjusted to be in a balance state; the activity of normal cells in the body are activated, and autoantibodies are formed.
Description
Technical field
What the present invention relates to is a kind of technology of tcm field, and specifically a kind of have antidiabetic drug of Chinese herb medicine and active catalytic element and preparation method thereof.
Background technology
Diabetes are a kind of commonly encountered diseases, frequently-occurring disease, and type ii diabetes is more common clinically, and treatment diabetes often can allow patient take hypoglycemic drug main will based on sulphanylureas and biguanides, and common medicine has glyburide, metformin, BAITANGPING etc.Clearly, but its side effect is very large for the hypoglycemic effect of these medicines.The antidiabetic drug of biguanides is comparatively large to the injury of the intestines and stomach, easily causes dyspepsia, may cause beta-oxybutyria and lactic acidosis time serious.The antidiabetic drug of sulphanylureas can cause leukopenia, hemolytic anemia.
Motherland's medical science is thought, the deficiency of YIN is the pathogenetic essence of glycosuria, insufficiency of the spleen be diabetes do not heal basic, blood stasis be diabetic complications produce key.
Integrally-regulated advantage can while blood sugar lowering, strengthen patient body constitution, the trace element of balanced human, correct its sugar, protein and fat metabolic disturbance, stimulate insulin secretion, regulate number or the affinity of Insulin receptor INSR, to increase the sensitivity of target cell to insulin.
Integrally-regulated advantage can prevent and treat the generation of diabetes multiple complications effectively.Obviously can reduce fatality rate, the disability rate of diabetic complication, significantly improve drug effect and onset time, obviously can reduce medical expense.
Diabetics majority also exists " blood stasis " that Chinese medicine is thought, both the Blood denseness that modern medicine had been said increases, hyperlipidemia and platelet aggregation rate increase these factors, cause blood at intravascular flow slowly, interrupt, make histanoxia, vascular endothelial injury, this is the basis of the concurrent cardiovascular and cerebrovascular disease of diabetics, peripheral angiopathy and important organ damage.While blood sugar lowering, Blood denseness and blood fat etc. can be reduced by benefiting QI for activating blood circulation.Remove sugar poison (ketosis acid) and blood vessel rubbish, thus prevent the generation of complication.
Chinese medicinal ointment spread on the former lifeblood Zhi Xue of human body kidney ?Yongquan acupoint, promote that drug osmotic enters the effect of human body, can ensure that medicine reaches whole body meridians thoroughly by foot, make the active ingredient of Chinese medicine sufficiently pass through hair and blood pipe and be circulated to whole body meridian, then follow channels and collaterals running to the vital organs of the human body, thus reach dredging the meridian, improve blood circulation, enhance metabolism, nervous system regulation, the trace element supplemented needed for absorption of human body Chinese medicine live part of science, makes it automatically to be adjusted to poised state; Thus improve biological function, swash in vivo normal cell viability, form autoantibody, improve body immunity.Thus reach inner disease outer treat, the effect on treating disease in the upper by managing the lower.There will not be again the excessive situation causing untoward reaction of oral drugs.
Summary of the invention
The present invention is directed to prior art above shortcomings, propose a kind of to there is antidiabetic drug of Chinese herb medicine and active catalytic element and preparation method thereof, make use of the secondary metabolite (as terpenoid, flavone, alkaloid, steroidal, lignin, mineral etc.) in active catalytic element component, to the mankind and various biology, there is physiology facilitation; The present invention can make blood glucose, glucose in urine steady in a long-term within normal range, and can the trace element supplemented needed for absorption of human body Chinese medicine live part of science, makes it automatically to be adjusted to poised state; Thus improve biological function, swash in vivo normal cell viability, form autoantibody, improve body immunity.Thus reach inner disease outer treat, the effect on treating disease in the upper by managing the lower.There will not be again the excessive situation causing untoward reaction of oral drugs, really can accomplish the curative effect of effecting a permanent cure.
The present invention is achieved by the following technical solutions:
The present invention relates to a kind of antidiabetic drug with Chinese herb medicine and active catalytic element, its effective ingredient comprises: the Chinese herb medicine component method Rhizoma Pinelliae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, the Radix Astragali, Semen Cuscutae, Cortex Cinnamomi, Fructus Lycii, Radix Bupleuri, Fructus Corni and active catalytic element component Caulis Momordicae Charantiae, Fructus Rosae Normalis, Wild Fructus Choerospondiatis.
Described has antidiabetic drug of Chinese herb medicine and active catalytic element and preparation method thereof, and its raw material components and content (with parts by weight) are: Rhizoma Pinelliae Preparatum 5 ~ 15 parts, Radix Achyranthis Bidentatae 5 ~ 15 parts, Radix Salviae Miltiorrhizae 5 ~ 15 parts, Fructus Ligustri Lucidi 5 ~ 20 parts, the Radix Astragali 5 ~ 15 parts, Semen Cuscutae 5 ~ 15 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 5 ~ 15 parts, Radix Bupleuri 5 ~ 15 parts, Fructus Corni 5 ~ 15 parts, Caulis Momordicae Charantiae 5 ~ 30 parts, Fructus Rosae Normalis 5 ~ 16 parts, Wild Fructus Choerospondiatis 20 ~ 40 parts.
The present invention relates to above-mentioned preparation method of falling the bound drug of the composition of hypoglycemic Chinese herb medicine and active catalytic element, comprise the following steps:
1) after active catalytic element component and the fermentation of corresponding ratio thereof are purified, in an aseptic environment Cai Yong ?the very fast ultra low temperature vacuum lyophilizing of 80 DEG C;
2) get Chinese herb medicine component and corresponding ratio carries out decocting liquid, add step 1 when last 20 clock of decocting liquid process) in the dry powder that obtains, cooling after 20 minutes concentration obtains hypoglycemic medicine finished product.
Described decocting liquid process, total duration 1.5 hours.
Described concentration, with concentrated solution proportion reach 1.15 ?1.20 to be as the criterion.
In described batching:
Rhizoma Pinelliae Preparatum refers to: removing Rhizoma Pinelliae Preparatum (RhizomaPinelliae) tuber, dries after removing crust and fibrous root;
Radix Achyranthis Bidentatae refers to: root and the stem of getting Radix Achyranthis Bidentatae (Achyranthesaspera) dry;
Fructus Ligustri Lucidi refers to: the dry mature fruit getting Fructus Ligustri Lucidi (LigustrumlucidumAit);
Semen Cuscutae refers to: get Semen Cuscutae (Cuscutachinensis Lam.) mature seed and dry;
Fructus Corni refers to: the drying and ripening sarcocarp getting Fructus Corni (CornusofficinalisSieb.et Zucc.);
Radix Salviae Miltiorrhizae refers to: get Radix Salviae Miltiorrhizae (Salvia miltiorrhizaBge.) dry root welding technology;
Caulis Momordicae Charantiae refers to: the dried stem getting Fructus Momordicae charantiae (Momordicacharantia L);
Fructus Rosae Normalis refers to: the drying and ripening sarcocarp getting Fructus Rosae Normalis (Rosa roxbunghii);
Wild Fructus Choerospondiatis refers to: the fruit getting the drying of Wild Fructus Choerospondiatis (Ziziphusjujubavar.spinosa (Bunge) Hu).
Technique effect
Compared with prior art, the present invention is this according to gas kidney Yin bivacuity in diabetes, and blood stasis is scorching is this key pathological link of mark, and catches " pathogen usually intruding into collateral in protracted disease " this feature, 1. adopts Rhizoma Pinelliae Preparatum, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Cortex Cinnamomi with supplementing QI and nourishing YIN; Kidney tonifying, essence replenishing; Strengthening the body resistance; Nourishing YIN and clearing away heat, effectively reduces blood glucose and glucose in urine, the deficiency of YIN of adjustment gas, kidney; 2. the Radix Astragali, Fructus Lycii, Radix Bupleuri, mountain cornel is adopted to stimulate insulin secretion; The quantity of adjustment Insulin receptor INSR and affinity; Increase target cell to the sensitivity of insulin; Reduce the gathering of sorbitol, the hypertrophy of tiny blood vessels of drawing up, prevents complication; Adjustment deficiency of spleen-YIN; 3. Semen Cuscutae, Fructus Ligustri Lucidi, Radix Puerariae, Radix Codonopsis is adopted to improve blood circulation; Promote new Chen Daili; Blood circulation promoting and blood stasis dispelling; Nervous system regulation; Dredging the meridian.4. Caulis Momordicae Charantiae, Fructus Rosae Normalis, Wild Fructus Choerospondiatis is adopted can to shorten the drug effect onset time of medicine; Can make effective ingredient accurately, concentrate, rapidly, directly send to needed by human body position; Greatly increase lesions position drug level; Supplement the trace element of human body disappearance, make it automatically to be adjusted to poised state; Swash in vivo normal cell viability, form autoantibody.
By the organic assembling of the different Chinese medicine of above-mentioned four large classes, the remarkable result produced compared to existing technology comprises:
1) avoid the excessive untoward reaction brought of oral drugs, comprise poison of drug and the repeatedly infringement of sugar poison to health;
2) blood glucose, glucose in urine decline stable;
3) compensate for traditional medicine long for the course for the treatment of, onset is blank slowly, and the trace element supplemented needed for absorption of human body Chinese medicine live part of science, makes it automatically to be adjusted to poised state;
4) progressively improve the biological function of health, swash in vivo normal cell viability, form autoantibody and improve immunity;
5) can make effective ingredient accurately, concentrate, rapidly, directly send to needed by human body position; Greatly increase lesions position drug level;
6) the various complication that diabetes may cause are avoided;
7) progressively adjust the gas deficiency of YIN, deficiency of the kidney yin, the deficiency of spleen-YIN of health, dissolve blood stasis.
8) diabetes are realized, while protein-loss carries out controlling, synchronous realization to the integrated regulation of the human organ such as gas, kidney,spleen,liver, solve can only controlling diabetes of medically existing at present and in the numerous cause of disease of diabetes, the problem can only treated certain disease;
9) the present invention can obvious dredging the meridian, and improve blood circulation, enhance metabolism, nervous system regulation, the trace element supplemented needed for absorption of human body Chinese medicine live part of science, makes it automatically to be adjusted to poised state; Thus improve biological function, swash in vivo normal cell viability, form autoantibody, improve body immunity.Thus reach inner disease outer treat, the effect on treating disease in the upper by managing the lower.There will not be again the excessive situation causing untoward reaction of oral drugs.
Detailed description of the invention
Elaborate to embodiments of the invention below, the present embodiment is implemented under premised on technical solution of the present invention, give detailed embodiment and concrete operating process, but protection scope of the present invention is not limited to following embodiment.
Embodiment 1
The present embodiment comprises the following steps:
1) get after active catalytic element component and the fermentation of corresponding ratio thereof purify, in an aseptic environment Cai Yong ?the very fast ultra low temperature vacuum lyophilizing of 80 DEG C;
2) get Chinese herb medicine component and corresponding ratio carries out decocting liquid, add step 1 when last 20 clock of decocting liquid process) in the dry powder that obtains, cooling after 20 minutes concentration obtains hypoglycemic medicine finished product.
This antidiabetic drug takes 5mL medicinal liquid at every turn, pours into and sticks in the sufficient heart " Yongquan acupoint " in the ring in the middle of medical adhesive-bonded fabric, keep more than 3 hours.Once a day, the continuous glycosuria that uses of rear blood glucose decline every day is used to paste blood glucose maintenance decline steadily after 12 months, cooperation medicine Hemoglobin Value after 16 months, feel run-down, walk difficult, xerostomia, kidney, the complication such as liver are controlled, in blood glucose remains stable, reduce oral other after using latter 4 years continuously and control sugared medication amount, type i diabetes people does not re-use insulin after using 10 years continuously and oral other control sugared medicine, the sick related complication disease of non-diabetic is sent out, the rehabilitation substantially afterwards that uses 15 years.After II type patient uses latter 6 years continuously, no longer oral other control sugared medicine, and the sick related complication disease of non-diabetic is sent out, the rehabilitation substantially afterwards that uses 10 years.(daily life system keeps rule always, under diet not being eaten the situation such as food that is pungent, that stimulate).
Embodiment 2
The present embodiment adopts the operating procedure identical with embodiment 1, and difference is that the constituent content of the present embodiment is for choosing Rhizoma Pinelliae Preparatum 10 parts, Radix Achyranthis Bidentatae 10 parts, Radix Salviae Miltiorrhizae 12 parts, Fructus Ligustri Lucidi 15 parts, the Radix Astragali 15 parts, Semen Cuscutae 10 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 10 parts, Radix Bupleuri 6 parts, Fructus Corni 10 parts, Caulis Momordicae Charantiae 20 parts, Fructus Rosae Normalis 10 parts, Wild Fructus Choerospondiatis 30 parts.
According to the antidiabetic drug that said ratio obtains, situation is as follows after a procedure:
After using decline every day of rear blood glucose to use 3 months continuously, blood glucose keeps decline steadily, cooperation medicine Hemoglobin Value after 8 months, feel run-down, difficulty of walking, xerostomia, kidney, the complication such as liver are controlled, and in blood glucose remains stable, reduce oral other and control sugared medication amount after using latter 1 year continuously, type i diabetes people does not re-use insulin after using 5 years continuously and oral other control sugared medicine, the basic rehabilitation afterwards that uses 7 years.After II type patient uses latter 3 years continuously, no longer oral other control sugared medicine, and the sick related complication disease of non-diabetic is sent out, the rehabilitation substantially afterwards that uses 5 years.(daily life system keeps rule always, under diet not being eaten the situation such as food that is pungent, that stimulate).
Embodiment 3
The present embodiment adopts the operating procedure identical with embodiment 1, and difference is that the constituent content of the present embodiment is: choose Rhizoma Pinelliae Preparatum 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Ligustri Lucidi 20 parts, the Radix Astragali 15 parts, Semen Cuscutae 15 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 15 parts, Radix Bupleuri 15 parts, Fructus Corni 15 parts, Caulis Momordicae Charantiae 30 parts, Fructus Rosae Normalis 16 parts, Wild Fructus Choerospondiatis 40 parts
According to the antidiabetic drug that said ratio obtains, situation is as follows after a procedure:
After using decline every day of rear blood glucose to use 8 months continuously, blood glucose keeps decline steadily, cooperation medicine Hemoglobin Value after 12 months, feel run-down, difficulty of walking, xerostomia, kidney, the complication such as liver are controlled, and in blood glucose remains stable, reduce oral other and control sugared medication amount after using latter 2 years half continuously, type i diabetes people does not re-use insulin after using 7 years continuously and oral other control sugared medicine, the basic rehabilitation afterwards that uses 10 years.After II type patient uses latter 4 years continuously, no longer oral other control sugared medicine, and the sick related complication disease of non-diabetic is sent out, the rehabilitation substantially afterwards that uses 7 years.(daily life system keeps rule always, under diet not being eaten the situation such as food that is pungent, that stimulate).
To sum up, because the present invention is without any side effects, harmless.Compare advantage with insulin with the sugared medicine of control to be to damage human body viscera, can substitute insulin and control sugared medicine with other, allowing diabetes patient thoroughly break away from needs to use the medicine sugared with oral control of insulin.
Claims (9)
1. one kind has the antidiabetic drug of Chinese herb medicine and active catalytic element, it is characterized in that, its effective ingredient comprises: the Chinese herb medicine component method Rhizoma Pinelliae, Radix Achyranthis Bidentatae, Radix Salviae Miltiorrhizae, Fructus Ligustri Lucidi, the Radix Astragali, Semen Cuscutae, Cortex Cinnamomi, Fructus Lycii, Radix Bupleuri, Fructus Corni and active catalytic element component Caulis Momordicae Charantiae, Fructus Rosae Normalis, Wild Fructus Choerospondiatis.
2. the antidiabetic drug with Chinese herb medicine and active catalytic element according to claim 1, it is characterized in that, its raw material components and content (with parts by weight) are: Rhizoma Pinelliae Preparatum 5 ~ 15 parts, Radix Achyranthis Bidentatae 5 ~ 15 parts, Radix Salviae Miltiorrhizae 5 ~ 15 parts, Fructus Ligustri Lucidi 5 ~ 20 parts, the Radix Astragali 5 ~ 15 parts, Semen Cuscutae 5 ~ 15 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 5 ~ 15 parts, Radix Bupleuri 5 ~ 15 parts, Fructus Corni 5 ~ 15 parts, Caulis Momordicae Charantiae 5 ~ 30 parts, Fructus Rosae Normalis 5 ~ 16 parts, Wild Fructus Choerospondiatis 20 ~ 40 parts.
3. the antidiabetic drug with Chinese herb medicine and active catalytic element according to claim 1 and 2, it is characterized in that, its raw material components and proportioning content (with parts by weight) are: Rhizoma Pinelliae Preparatum 5 parts, Radix Achyranthis Bidentatae 5 parts, Radix Salviae Miltiorrhizae 5 parts, Fructus Ligustri Lucidi 5 parts, the Radix Astragali 5 parts, Semen Cuscutae 5 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 5 parts, Radix Bupleuri 5 parts, Fructus Corni 5 parts, and formula is Caulis Momordicae Charantiae 5 parts, Fructus Rosae Normalis 5 parts, Wild Fructus Choerospondiatis 20 parts 2..
4. the antidiabetic drug with Chinese herb medicine and active catalytic element according to claim 1 and 2, it is characterized in that, its raw material components and proportioning content (with parts by weight) are: Rhizoma Pinelliae Preparatum 10 parts, Radix Achyranthis Bidentatae 10 parts, Radix Salviae Miltiorrhizae 12 parts, Fructus Ligustri Lucidi 15 parts, the Radix Astragali 15 parts, Semen Cuscutae 10 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 10 parts, Radix Bupleuri 6 parts, Fructus Corni 10 parts, Caulis Momordicae Charantiae 30 parts, Fructus Rosae Normalis 16 parts, Wild Fructus Choerospondiatis 40 parts, Caulis Momordicae Charantiae 20 parts, Fructus Rosae Normalis 10 parts, Wild Fructus Choerospondiatis 30 parts.
5. the antidiabetic drug with Chinese herb medicine and active catalytic element according to claim 1 and 2, it is characterized in that, its raw material components and proportioning content (with parts by weight) are: Rhizoma Pinelliae Preparatum 15 parts, Radix Achyranthis Bidentatae 15 parts, Radix Salviae Miltiorrhizae 15 parts, Fructus Ligustri Lucidi 20 parts, the Radix Astragali 15 parts, Semen Cuscutae 15 parts, Cortex Cinnamomi 5 parts, Fructus Lycii 15 parts, Radix Bupleuri 15 parts, Fructus Corni 15 parts, Caulis Momordicae Charantiae 30 parts, Fructus Rosae Normalis 16 parts, Wild Fructus Choerospondiatis 40 parts.
6. the preparation method of antidiabetic drug according to above-mentioned arbitrary claim, is characterized in that, comprise the following steps:
1) get after active catalytic element component and the fermentation of corresponding ratio thereof purify, in an aseptic environment Cai Yong ?the very fast ultra low temperature vacuum lyophilizing of 80 DEG C;
2) get Chinese herb medicine component and corresponding ratio carries out decocting liquid, add step 1 when last 20 clock of decocting liquid process) in the dry powder that obtains, cooling after 20 minutes concentration obtains hypoglycemic medicine finished product.
7. method according to claim 6, is characterized in that, described decocting liquid process, total duration 1.5 hours.
8. method according to claim 6, is characterized in that, described concentration, with concentrated solution proportion reach 1.15 ?1.20 to be as the criterion.
9. method according to claim 6, is characterized in that, in described batching:
Rhizoma Pinelliae Preparatum refers to: removing Rhizoma Pinelliae Preparatum (RhizomaPinelliae) tuber, dries after removing crust and fibrous root;
Radix Achyranthis Bidentatae refers to: root and the stem of getting Radix Achyranthis Bidentatae (Achyranthesaspera) dry;
Fructus Ligustri Lucidi refers to: the dry mature fruit getting Fructus Ligustri Lucidi (LigustrumlucidumAit);
Semen Cuscutae refers to: get Semen Cuscutae (Cuscutachinensis Lam.) mature seed and dry;
Fructus Corni refers to: the drying and ripening sarcocarp getting Fructus Corni (CornusofficinalisSieb.et Zucc.);
Radix Salviae Miltiorrhizae refers to: get Radix Salviae Miltiorrhizae (Salvia miltiorrhizaBge.) dry root welding technology;
Caulis Momordicae Charantiae refers to: the dried stem getting Fructus Momordicae charantiae (Momordicacharantia L);
Fructus Rosae Normalis refers to: the drying and ripening sarcocarp getting Fructus Rosae Normalis (Rosa roxbunghii);
Wild Fructus Choerospondiatis refers to: the fruit getting the drying of Wild Fructus Choerospondiatis (Ziziphusjujubavar.spinosa (Bunge) Hu).
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| 白丽君等: "温肾健脾法治疗老年糖尿病56例", 《陕西中医》 * |
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Application publication date: 20150930 |