CN104906361A - Hypolipidemic yellow rice wine and making method thereof - Google Patents
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Abstract
The invention discloses hypolipidemic yellow rice wine and a making method thereof, and belongs to the technical field of brewing of health-care food. Hypolipidemic Chinese herbal material extracting liquid is added before storage of yellow rice wine, and the hypolipidemic yellow rice wine is finally obtained after storage, settling, filtering and sterilization. The raw materials of the hypolipidemic yellow rice wine include, by weight, 100 parts of yellow rice wine, 1.0-1.5 parts of raw hawthorn fruit, 2.0-2.5 parts of sealwort, 1.0-1.2 parts of dried lotus leaves, 1.0-1.2 parts of chrysanthemum, 1.5-2.0 parts of barbary wolfberry fruit, 0.6-0.8 part of cape jasmine, 0.5-0.7 part of peach seeds, 0.5-0.6 part of radix pueraiae, 0.5-0.6 part of semen cassiae and 0.2-0.3 part of glycyrrhiza. A Chinese herbal material ultrasonic extracting method has the advantages of saving time and energy, being high in extraction rate and the like. The total flavonoid content of the produced yellow rice wine is 176.78-210.52 mg/100ml. The hypolipidemic effects of relieving obesity, reducing fat, reducing the content of TG, TC and LDL-C and improving the content of HDL-C are realized. The hypolipidemic yellow rice wine can adjust the functions of the cardiovascular system of the human body, has no side and toxic effects, and is suitable for wide people.
Description
Technical field
A kind of blood fat reducing yellow wine and preparation method thereof, belongs to health food technology and brewing technology.
Background technology
It is reported, along with improving constantly of people's living standard, the sickness rate of hyperlipemia is obvious ascendant trend.China dies from the number of cardiovascular and cerebrovascular disease every year more than 2,000,000, accounts for 1/3 of total death toll.Cardiovascular and cerebrovascular disease is a kind of complexity, the multifactor disease caused, research shows that blood fat (cholesterol and triglyceride) raises, in blood plasma, fibrinogen and aggregation factor concentration increase, biologically active pdgf increases, and blood viscosity increases, and blood flow rate slows down, make lipid and hemocyte and vessel wall contact time lengthening, be easy to intravasation wall deposition, causing atherosclerosis and thrombosis, is the primary paathogenic factor of cardiovascular and cerebrovascular disease.Hyperlipidemia is again the key factor of bringing out coronary atherosclerotic heart disease (coronary heart disease), arteriosclerosis, fatty liver, diabetes, obesity etc.Blood lipid-lowering medicine is widely used in the blood fat conditioning of clinical hyperlipidemia patient at present, abnormal for improving Human Lipid Metabolism, decreases beyond the blood plasma lipide concentration of normal range.The blood lipid-lowering medicine applied clinically mainly contains statins, fibrate, nicotinic acid class medicine, cholic acid chelating agent class medicine and polyenoic fatty acids medicine, the untoward reaction that blood lipid-lowering medicine causes also causes concern, does not also have the specially good effect hypolipidemic that toxic and side effects is little at present.Therefore the blood lipid-lowering medicine finding high effect nontoxic has important realistic meaning.
In recent years, along with the development of food industry and people are to the continuous lifting of food safety health care consciousness, the dynamics of Chinese herbal medicines exploitation strengthens day by day.Some composition of food medicine dual-purpose is utilized day by day to be subject to people's attention to reach blood fat reducing object, untoward reaction is few, comparitive study is definite, there is again multiple effect for reducing blood fat approach, can prescription, giving treatment in accordance with the patient’s individuality flexibly, so have broad application prospects (Zhuan Ruifeng. Reducing Blood Lipid by Chinese medicine Effect study progress [J]. Hebei medicine, the 2009,31st volume the 9th phase: 1119-1121).
Chinese herbal medicines is the product that the distinctive theory of Chinese medical science of China combines with practice, that a class has nutrition and medicinal dual function concurrently, have and directly kill or the function of anti-bacteria and enhancing immunocompetence, and the noresidue that nutrient digestion absorbs, the natural drug had no drug resistance can be promoted.Research shows that Chinese herbal medicine extract contains the bioactive substances such as flavone compound, alkaloid, polysaccharide, volatile oil, tannin, organic acid.It can reach sterilization, antibacterial, conditioner body immunity function and metabolism by these bioactive substances, improves the effect of human health level.Flavone compound (flavonoid) is also known as flavonoids, flavone; it is the element of the first species distributed more widely in plant kingdom; there is the effect of the functions such as antioxidation, antiinflammatory, antiallergic action and raising immunity of organisms and control chronic degenerative diseases; a large amount of cell culture studies and results of animal all show; some flavonoid substances also have stronger antimicrobial, chelated metal ions, protection DNA, suppress the effects such as low density lipoprotein, LDL (LDL) oxidation and growth of tumour cell.Its physiologically active of flavone compound is various, and blood fat reducing realizes mainly through antioxidation, and in On behalf of plant, Fructus Crataegi is parts of generic medicinal plants, and main is main flavonoid organic acid containing hyperin, obviously can reduce mice serum TC and raise HDL-TC.Alkaloid there is maximum class chemical compositions in natural drug, has strong physiologically active.As utilized lotus leaf alkaloid preparation feed hyperlipemia in mice, the content of its serum TC has obvious reduction; Contained glucomannoglycan in lycium barbarum polysaccharide, Cordyceps militaris polysaccharide, laminarin, ulva polysaccharide and Rhizoma amorphophalli. significantly can reduce TC, TG level in hyperlipemia animal blood fat, improve HDL-C value simultaneously.Therefore, the research of Chinese herbal medicines flavonoid substances, polysaccharide and alkaloid activity ingredients Biogenic Function and its mechanisms has become one of focus in current nutrition and food scientific research field.
Be at present that the yellow wine of raw material mostly adopts Chinese medicine to be added in fermentation raw material and obtains with medicine-food two-purpose, its shortcoming does not have quantitative analysis comparative study, causes the active ingredient of Chinese medicine to run off in a large number, drug effect and effect not good.The present invention relates to a kind of blood fat reducing yellow wine and preparation method thereof, Chinese crude drug extracting solution containing Flavonoid substances, polysaccharide, alkaloid activity composition is added in the yellow wine old storage stage, finished wine presents steady statue, without Precipitation, and greatly strengthen the health functions of yellow wine.
Summary of the invention
The technical problem to be solved in the present invention is, for strengthening the health care of yellow wine, human serum cholesterol TC, triglyceride TG are reduced, serum High Density Lipoprotein Cholesterol HDL-C raises, height blood pressure tends to balance simultaneously, propose a kind of blood fat reducing yellow wine and preparation method thereof, obtained yellow wine is rich in flavone compound, polysaccharide, alkaloid activity composition, has comprehensive adjustment cardiovascular system of human body, digestive system and immune system.
The present invention solves the problems of the technologies described above adopted technical scheme:
By Study of Traditional Chinese Medicine pharmacology, chemical composition, carry out the screening of active drug, the pharmaceutical formulation that lipid-lowering effect of drawing up out is good; In production process of yellow rice wine, yellow wine fermentation, squeeze, decoct after drinking, before the old storage of wine liquid, add Chinese traditional medicines depressing lipid material Chinese medicine extraction liquid, then through old storage, clarification, filtration and and sterilization, be finished product.The finished product yellow wine produced is rich in flavone compound, polysaccharide hypolipidemic activity composition.
A kind of blood fat reducing yellow wine and preparation method thereof, adopts existing yellow wine production technology.Wherein said raw material number, except specified otherwise, is parts by weight, is made up of following raw material:
Yellow wine 100, Fructus Crataegi 1.0-1.5, Rhizoma Polygonati 2.0-2.5, dry Folium Nelumbinis 1.0-1.2, Flos Chrysanthemi 1.0-1.2, Fructus Lycii 1.5-2.0, Fructus Gardeniae 0.6-0.8, Semen Persicae 0.5-0.7, Radix Puerariae 0.5-0.6, Semen Cassiae 0.5-0.6, Radix Glycyrrhizae 0.2-0.3.
In this Chinese medicine formula, Fructus Crataegi, sour in the mouth is sweet, slightly warm in nature, return taste Liver Channel, the traditional Chinese medical science is used for promoting digestion and removing stagnation, promoting blood circulation to remove blood stasis, containing procyanidin, take Quercetin as the flavone compound of representative, triterpenoid compound and organic acid, there is heart tonifying, increase coronary blood flow, improve the effects such as blood circulation;
Rhizoma Polygonati, energy nourishing YIN and moistening the lung, spleen reinforcing stomach reinforcing, containing functional components such as Rhizoma Polygonati Saponin, flavone compound and polygonatum polysaccharides, has protection cardiovascular and cerebrovascular vessel, reduces blood fat, reduces blood glucose, enhancing human body immunity function;
Folium Nelumbinis, there is effect of clearing away summer-heat, sending up the lucid YANG, cooling blood for hemostasis, be mainly used in summer-heat excessive thirst, diarrhea due to summer heat and dampness, heat in blood tells nosebleed, the diseases such as metrorrhagia of having blood in stool, mainly containing alkaloid, flavone, volatilization wet goods composition, wherein the biological activity of flavone and alkaloid compound is higher, has regulating lipid and reducing weight, antioxidant and anti-aging, bacteriostasis;
Flos Chrysanthemi, dispelling wind, heat clearing away, improving eyesight, removing toxic substances, controls headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling.Containing adenine, choline, stachydrine and chrysanthemum glycoside, flavonoid functional component, there is hypotensive effect to hyperpietic;
Fructus Lycii, sweet in the mouth, property are flat, containing multiple nutritional components such as Fructus Lycii proteoglycan, vitamin C, phosphorus, ferrum, have nourishing YIN and supplementing blood, the effects such as replenishing vital essence to improve eyesight;
Fructus Gardeniae, there is the effects such as hepatoprotective, function of gallbladder promoting, blood pressure lowering, calmness, hemostasis, detumescence, containing flavonoid gardenin, pectin, tannin, crocin, crocetin, PEARLITOL 25C, nonacosane, cupreol, the another glycoside containing the smelly formaldehyde structure of multiple tool ring: gardenoside, geniposide pool element-1-glycoside, lattice Tegosept P-1-β-D-gentiobioside and Fructus Gardeniae in a small amount, be usually used in the diseases such as treatment icterohepatitis, bruise, hypertension, diabetes at tcm clinical practice;
Semen Persicae, sweet flat, the bitter in the mouth of property, enters lung, liver, large intestine channel, has blood circulation promoting and blood stasis dispelling, effect of relaxing bowel effect.For amenorrhea, dysmenorrhea ， WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation.The main component of Semen Persicae, containing compounds such as amygdalin, sterol, flavonoid, phenolic acids, proves that it has the pharmacological actions such as anticoagulation, antithrombotic, prevention hepatic fibrosis and enhancing immunity;
Radix Puerariae, sweet in the mouth, pungent, property is put down, flavone compound is planted containing Semen sojae atricolor (Semen Glycines) glycoside, daidzein, puerarin etc. more than 10, and containing daucosterol, aminoacid, Coumarins etc., cure the wound cold, warm headache stiffness of the nape, and dysphoria with smothery sensation is quenched one's thirst, have loose bowels, dysentery, skin eruption is not saturating, hypertension, angina pectoris, deaf;
Semen Cassiae, Semen Cassiae sweet in the mouth, hardship, salty, cold nature, is apt to, into liver, kidney, large intestine channel, to have effect of liver heat removing and eyesight improving, loosening bowel to relieve constipation.Main component is that anthraquinone component accounts for 1%.Semen Cassiae has better blood fat reducing, blood pressure lowering, antioxidation, anti-ageing curative effect of waiting for a long time.Modern pharmacology research shows, Semen Cassiae suppresses the effect of serum cholesterol rising and atheromatous plaque, and lipid-lowering effect is remarkable;
Radix Glycyrrhizae, by effect of its QI invigorating strengthening the spleen and middle emergency, coordinating the actions of various ingredients in a prescription, main in Radix Glycyrrhizae have and have antiinflammatory action containing material compositions such as glycyrrhizic acid, liquiritin and flavone, use the fragrance simultaneously increasing fermented wine in distillers yeast, improves denseness and the color and luster of wine.
A kind of blood fat reducing yellow wine of the present invention and preparation method thereof, concrete implementation step is:
(1) extraction of Chinese crude drug
A, conventional hot water's extraction method
Fructus Crataegi, Rhizoma Polygonati, Radix Puerariae, Radix Glycyrrhizae are thinly sliced, dry Folium Nelumbinis is ground into 2 × 2cm size, Semen Persicae, Fructus Gardeniae, Semen Cassiae are rolled into flap, powder 1 ~ 2cm was flooded, solid-liquid ratio 1: 15, then soak time 3h with Flos Chrysanthemi, Fructus Lycii mixing and water adding, infusion 30 ~ 40min under 90-95 DEG C of condition, filtration obtains medicine juice, uses clear water infusion medicine 3 times continuously, filtrate is mixed, filtrate is concentrated into parts by weight 4 ~ 5, saves backup;
B, ultrasonic extraction
Fructus Crataegi, Rhizoma Polygonati, Radix Puerariae, Radix Glycyrrhizae are thinly sliced, dry Folium Nelumbinis is ground into 2 × 2cm size, Semen Persicae, Fructus Gardeniae, Semen Cassiae are rolled into flap, floods powder 1 ~ 2cm, solid-liquid ratio 1: 10 with Flos Chrysanthemi, Fructus Lycii mixing and water adding, then soak time 3h is 5-10w/cm at ultrasonic power
2, supersound extraction time 20min under frequency 30-50khz, 60-65 DEG C of condition, filters and obtains medicine juice, and extract medicine 3 times with clear water continuously, filtrate mixed, filtrate is concentrated into parts by weight 4 ~ 5, saves backup;
(2) interpolation of Chinese crude drug extracting solution
Added in proportion in yellow wine by above-mentioned Chinese crude drug extracting solution before the old storage of yellow wine liquid, mix is even; Then through old storage, clarification, filtration and and sterilization, be finished product.
The present invention has following good effect:
1, extract in Chinese crude drug technical process, without any additive, can retain the maximum medicinal effects of Chinese crude drug, can not destroy again the original local flavor of yellow wine, yellow wine medicated incense is gentle, fragrant;
2, before the old storage of wine liquid, add formula Chinese traditional medicines depressing lipid material extracting solution, nutritional labeling is stablized, and does not produce precipitation;
3, adopt original yellow wine production technology, add Chinese crude drug extracting solution, amino acid nitrogen in rice wine 0.63-0.65g/L, average 0.64g/L, improve 10.34% with not adding compared with Chinese crude drug yellow wine; Total sugar (with glucose meter) 36.50-37.46g/L, average 36.98g/L are 2.34 times that do not add Chinese crude drug yellow wine; Non-saccharide solid 31.32-32.37g/L, average 31.85g/L, be 1.20 times that do not add Chinese crude drug yellow wine; General flavone content reaches 176.78-210.52mg/100ml, average content 193.65mg/100ml, is 4.18 times that do not add Chinese crude drug yellow wine;
4, Chinese crude drug ultrasonic extraction produce yellow wine, have save time, cost is low, extraction ratio advantages of higher, Chinese crude drug ultrasonic extraction produce yellow wine general flavone content improve 19.1% than conventional hot water extraction method;
5, the yellow wine of the present invention's production, have after drinking that fat body weight reduces, fat reduces and TG, TC, LDL-C content reduces, and the better effects that HDL-C content promotes, can comprehensive adjustment cardiovascular system of human body, digestive system and function of immune system, and have no side effect, be suitable for crowd wide.
Detailed description of the invention
Below by embodiment, the present invention is specifically described; what be necessary to herein means out is that the present embodiment is only used to further illustrate the present invention; but can not limiting the scope of the invention be interpreted as, some nonessential improvement and adjustment can be made according to the content of the invention described above.
Embodiment 1 the present invention is a kind of by blood fat yellow wine and preparation method thereof, is made up of following raw material:
Yellow wine 100, Fructus Crataegi 1.0, Rhizoma Polygonati 2.0, dry Folium Nelumbinis 1.0, Flos Chrysanthemi 1.0, Fructus Lycii 1.5, Fructus Gardeniae 0.6, Semen Persicae 0.5, Radix Puerariae 0.5, Semen Cassiae 0.5, Radix Glycyrrhizae 0.2.
Concrete implementation step is:
(1) extraction of Chinese crude drug
A, conventional hot water's extraction method
Fructus Crataegi, Rhizoma Polygonati, Radix Puerariae, Radix Glycyrrhizae are thinly sliced, dry Folium Nelumbinis is ground into 2 × 2cm size, Semen Persicae, Fructus Gardeniae, Semen Cassiae are rolled into flap, powder 1 ~ 2cm was flooded, solid-liquid ratio 1: 15, then soak time 3h with Flos Chrysanthemi, Fructus Lycii mixing and water adding, 95 DEG C of infusion 40min, filtration obtains medicine juice, uses clear water infusion medicine 3 times continuously, filtrate is mixed, filtrate is concentrated into Chinese crude drug extracting solution parts by weight 4, saves backup;
B, ultrasonic extraction
Fructus Crataegi, Rhizoma Polygonati, Radix Puerariae, Radix Glycyrrhizae are thinly sliced, dry Folium Nelumbinis is ground into 2 × 2cm size, Semen Persicae, Fructus Gardeniae, Semen Cassiae are rolled into flap, floods powder 1 ~ 2cm, solid-liquid ratio 1: 10 with Flos Chrysanthemi, Fructus Lycii mixing and water adding, then soak time 3h is 10w/cm at ultrasonic power
2, frequency 40khz, supersound extraction time 20min at 60 DEG C, filter and obtain medicine juice, and extract medicine 3 times with clear water continuously, filtrate mixed, filtrate is concentrated into Chinese crude drug extracting solution parts by weight 4, saves backup;
(2) interpolation of Chinese crude drug extracting solution
Add in yellow wine by above-mentioned Chinese crude drug extracting solution before the old storage of wine liquid, mix is even, then through old storage, clarification, filtration and and sterilization, be finished product.
Finished product yellow wine physical and chemical index testing result is in table 1
Table 1 Chinese crude drug yellow wine contrasts with yellow wine (blank) each physical and chemical index not adding Chinese crude drug
As can be seen from Table 1, the amino-acid nitrogen of the Chinese crude drug yellow wine obtained according to method provided by the invention, total sugar, non-saccharide solid, total flavones higher than not adding Chinese crude drug yellow wine (blank yellow wine), namely the nutritive value of Chinese crude drug yellow wine and quality more excellent; Conventional hot water's extraction method is compared with ultrasonic extraction, the Chinese crude drug liquid of ultrasonic extraction is used for yellow wine, its amino-acid nitrogen, total sugar, non-saccharide solid, total flavones are higher than conventional hot water's extraction method, have save time, cost is low, extraction ratio advantages of higher, therefore, when using method of the present invention to extract Chinese crude drug, use the mode of ultrasonic extraction Chinese crude drug more excellent.
Embodiment 2 drug effect is implemented
(1) examination criteria
The regulation of " function of health food assessment process and the method for inspection " sent out is promulgated according to Ministry of Health of the People's Republic of China;
Serum cholesterol TC, the total triglyceride TG of serum, serum High Density Lipoprotein Cholesterol HDL-C, serum LDL cholesterol LDL-C;
Effective judgement: TC reduces > 10%, TG and reduces > 10%, HDL-C rising > 0.104mmol/L;
Invalid judgement: do not reach effective standard person.
(2) test method
A, animal feed
Normal feedstuff formula is made up of following raw material: Semen Maydis flour 30, soybean cake powder 20, Testa Tritici 25, flour 16, fish flour 5, bone meal 2, yeast powder 1, Sal 1.Fat energy supply ratio is 17.8%;
High lipid food formula is made up of following raw material: normal feedstuff 78.8, cholesterol 1, yolk powder 10, sodium cholate 0.2, Adeps Sus domestica 10.Fat energy supply is than 44.1%;
B, yellow wine are hot water extraction Chinese crude drug yellow wine, alcoholic strength 15%vol.
The male Sprague-Dawley of c, II level (SD) rat, normal feedstuff adaptability feeds 7 days, and random point 10 is matched group (C group), and continue to feed normal feedstuff, all the other rats feed high lipid food.14th day, get tail hematometry TC, TG, HDL-C and LDL-C.According to TC level, rat is divided into three groups, high fat matched group (HF group respectively, tap water gavage volume is 10ml/kg.bw), low drink yellow wine intervention group (LX group, first by the distilled water half-and-half dilution of alcoholic strength 15%vol yellow wine, gavage volume 10mL/kg.bw), high drink yellow wine intervention group (HX group, alcoholic strength 15%vol yellow wine gavage 10mL/kg.bw), often organize rat experiment number n=10.Grouping the same day be experiment the 0th day, every 2 days gavages 1 time, afternoon, 14:00 point was to rat oral gavage.Every morning, 8:00 recorded food-intake and body weight, observed rat ordinary circumstance.Experiment periods is 28 days.
D, date processing
Result is used
represent, analyze the significant difference between many groups with SPSS13.0 statistical software One Way-ANOVA.
Effective percentage=(HF group detected value-LX organizes and HX group average detectable value) ÷ HF group detected value × 100%
(3) experimental result
A, animal general state
All laboratory animals all do not have death, and general state is good, and any disease does not occur, and hair color is smooth, movable without exception.
The change of b, rat body weight
Experimental session respectively organizes rat body weight significantly to be increased, and the change of experimental session rat body weight is in table 2, and wherein increasing maximum is high fat matched group (HF group), and other group body weight increase does not have significant difference.28 days HF groups are on average put on weight 155.8g, are that LX, HX group is on average put on weight 1.35 times of 115.15g, lose weight effective percentage 26.1%, illustrate that yellow wine of the present invention reduces to maintenance high lipid food rat body weight the effect had to the obesity that high fat causes.
Table 2 for the change of experimental session rat body weight, (use by result
represent, often organize rat experiment number n=10, body weight g);
In table 2, * represents and C, LX, HX group compares p < 0.05; # represents and compares p < 0.05 with HF group.
The change of c, rat TG
Yellow wine in table 3, does not have significant change to 14 days C groups on the impact of rat TG level, and all the other 3 groups are still raising, and be significantly higher than matched group (C group) (p < 0.05), LX, HX group is then remarkable in HF group; 28th day HF group TG content 3.25mmol/L is 2.48 times of LX, HX class mean 1.325mmol/L, reduces effective percentage 59.2% to TG content, illustrates that yellow wine of the present invention reduces to maintenance high lipid food rat TG content the effect had.
Table 3 is that yellow wine on the impact of rat TG level, (use by result
represent, often organize rat experiment number n=10, unit mmol/L)
In table 3, * represents and LX, HX and HF group compares p < 0.05; # represents and compares p < 0.05 with HF group; $ represents and compares p < 0.05 with HF group.
The change of d, rat TC
The situation of change of TC is substantially identical with TG, yellow wine on the impact of rat TC level in table 4.Grouping matched group on the same day is significantly lower than other 3 groups, and HF, LX, HX 3 groups of results are close, and we divide into groups according to the amount of TC, and grouping basis equalization is described.28 days HF group TC content 4.40mmol/L are 1.58 times of LX, HX group average content 2.78mmol/L, and yellow wine reduces effective percentage 36.82% to TC content, illustrate that yellow wine of the present invention has good effect to the reduction of maintenance high lipid food rat TC content.
Table 4 yellow wine on the impact of rat TC level, (use by result
represent, often organize rat experiment number n=10, unit mmol/L);
In table 4, * represents and compares p < 0.01 with HF, LX and HX group; # represents and compares p < 0.05 with HF group; $ represents and compares p < 0.05 with HF group.
The change of e, rat HDL-C
Yellow wine on the impact of rat HDL-C level in table 5,28th day HF group HDL-C content 0.75mmol/L, and LX, HX class mean 1.395mmol/L, HDL-C content rising 0.645mmol/L, effective percentage being promoted 86% to HDL-C content, illustrating that yellow wine of the present invention stablizes to maintaining high lipid food rat HDL-C the effect promoting and had.
Table 5 is that yellow wine on the impact of rat HDL-C level, (use by result
represent, often organize rat experiment number n=10, unit mmol/L);
In table 5, * represents and compares p < 0.05 with HF group.
The change of f, rat LDL-C
Yellow wine on the impact of rat LDL-C level in table 6,28th day HF group LDL-C content 1.56mmol/L, and LX, HX class mean 0.58mmol/L, the yellow wine that the present invention produces reduces 0.98mmol/L to LDL-C content, effective percentage is reduced 62.8% to LDL-C content, the effect that yellow wine of the present invention has had maintenance high lipid food rat LDL-C steady decrease is described.
Table 6 yellow wine on the impact of rat LDL-C level, (use by result
represent, often organize rat experiment number n=10, unit mmol/L);
In table 6, * represents and HF, LX and HX group compares p < 0.05; # represents and C, LX and HX group compares p < 0.05.
The change of g, large Adips Mus body ratio
From table 7, illustrate that after using yellow wine of the present invention to intervene, rat each several part fat all has minimizing, after particularly high dose is intervened, subcutaneous rat fat significantly reduces (P < 0.05);
Table 7 yellow wine is on the impact (%) of large Adips Mus body ratio;
In table 7, * represents and C, LX and HX group compares p < 0.05.
Low drink yellow wine intervention group (LX group), by the half-and-half dilution of alcoholic strength 15%vol yellow wine distilled water, 2 days one time gavage volume 10mL/kg.bw, then press ethanol gauge to calculate, the people being equivalent to a 60kg drinks the commodity yellow wine 300mL that alcohol concentration is 15%vol for 2 days, or alcohol concentration is the commodity yellow wine 450mL of 10%vol; High drink yellow wine intervention group (HX group), alcoholic strength 15%vol yellow wine 2 days one time gavage volume 10mL/kg.bw, the people being equivalent to a 60kg drinks the commodity yellow wine 600mL that alcohol concentration is 15%vol for 2 days, or alcohol concentration is the commodity yellow wine 900mL of l0%vol.Zoopery confirms, through experiment in 28 days, proves the yellow wine that the present invention produces, and has the reduction of fat body weight, fat reduces and TG, TC, LDL-C content reduces, and the better effects that HDL-C content promotes.Therefore, the yellow wine that the present invention produces, the commodity yellow wine amount of the average daily potable spirit concentration 15%vol of people of 60kg is 150mLL, can reach lipid-lowering effect.
Claims (3)
1. blood fat reducing yellow wine and preparation method thereof, belongs to health food technology and brewing technology, and its feature comprises the following steps:
(1) raw material is made up of following raw material:
Yellow wine 100, Fructus Crataegi 1.0-1.5, Rhizoma Polygonati 2.0-2.5, dry Folium Nelumbinis 1.0-1.2, Flos Chrysanthemi 1.0-1.2, Fructus Lycii 1.5-2.0, Fructus Gardeniae 0.6-0.8, Semen Persicae 0.5-0.7, Radix Puerariae 0.5-0.6, Semen Cassiae 0.5-0.6, Radix Glycyrrhizae 0.2-0.3;
(2) extraction of Chinese crude drug
A, conventional hot water's extraction method
Fructus Crataegi, Rhizoma Polygonati, Radix Puerariae, Radix Glycyrrhizae are thinly sliced, dry Folium Nelumbinis is ground into 2 × 2cm size, Semen Persicae, Fructus Gardeniae, Semen Cassiae are rolled into flap, powder 1 ~ 2cm was flooded, solid-liquid ratio 1: 15, then soak time 3h with Flos Chrysanthemi, Fructus Lycii mixing and water adding, infusion 30 ~ 40min under 90-95 DEG C of condition, filtration obtains medicine juice, uses clear water infusion medicine 3 times continuously, filtrate is mixed, filtrate is concentrated into parts by weight 4 ~ 5, saves backup;
B, ultrasonic extraction
Fructus Crataegi, Rhizoma Polygonati, Radix Puerariae, Radix Glycyrrhizae are thinly sliced, dry Folium Nelumbinis is ground into 2 × 2cm size, Semen Persicae, Fructus Gardeniae, Semen Cassiae are rolled into flap, floods powder 1 ~ 2cm, solid-liquid ratio 1: 10 with Flos Chrysanthemi, Fructus Lycii mixing and water adding, then soak time 3h is 5-10w/cm at ultrasonic power
2, supersound extraction time 20min under frequency 30-50khz, 60-65 DEG C of condition, filters and obtains medicine juice, and extract medicine 3 times with clear water continuously, filtrate mixed, filtrate is concentrated into parts by weight 4 ~ 5, saves backup;
(3) interpolation of Chinese crude drug extracting solution
Added in proportion in yellow wine by above-mentioned Chinese crude drug extracting solution before the old storage of yellow wine liquid, mix is even; Then through old storage, clarification, filtration and and sterilization, be finished product.
2. require a kind of blood fat reducing yellow wine and preparation method thereof according to right 1, it is characterized in that Chinese crude drug ultrasonic extraction is compared with conventional hot water's extraction method, have save time, cost is low, extraction ratio advantages of higher, Chinese crude drug ultrasonic extraction produce yellow wine general flavone content than conventional hot water extraction method improve 19.1%.
3. require a kind of blood fat reducing yellow wine and preparation method thereof according to right 1, it is characterized in that adopting original yellow wine production technology, before the old storage of yellow wine liquid, add Chinese crude drug extracting solution, wherein in yellow wine, general flavone content reaches 176.78-210.52mg/100ml, average content 193.65mg/100ml.
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309913A (en) * | 2016-08-31 | 2017-01-11 | 广州领康科技有限公司 | Cassia seed and sea buckthorn contained herbal tea with function of targeted repairing of blood vessels |
| CN106754136A (en) * | 2016-12-29 | 2017-05-31 | 甘肃滨河食品工业（集团）有限责任公司 | A kind of garlic health preserving wine and preparation method thereof |
| CN108117961A (en) * | 2018-01-26 | 2018-06-05 | 贵州理工学院 | A kind of minuent health preserving wine and preparation method thereof |
| CN109055141A (en) * | 2018-10-08 | 2018-12-21 | 浙江中医药大学 | A kind of blackberry, blueberry yellow rice wine and its preparation method and application |
| CN110144276A (en) * | 2019-05-15 | 2019-08-20 | 四川大学 | A preparation process of health wine with anti-fatigue function |
| CN114223895A (en) * | 2021-11-09 | 2022-03-25 | 上海椿龄健康管理有限公司 | Food formula for preventing and treating hyperlipidemia |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102258708A (en) * | 2011-07-12 | 2011-11-30 | 深圳市慧慈现代生物科技有限公司 | Health-preserving wine and preparation method thereof |
| CN102641355A (en) * | 2012-05-22 | 2012-08-22 | 楚雄医药高等专科学校 | Composition processed with wine and health care wine for treating hyperlipoidemia, and preparation method and application of health care wine |
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Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102258708A (en) * | 2011-07-12 | 2011-11-30 | 深圳市慧慈现代生物科技有限公司 | Health-preserving wine and preparation method thereof |
| CN102641355A (en) * | 2012-05-22 | 2012-08-22 | 楚雄医药高等专科学校 | Composition processed with wine and health care wine for treating hyperlipoidemia, and preparation method and application of health care wine |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106309913A (en) * | 2016-08-31 | 2017-01-11 | 广州领康科技有限公司 | Cassia seed and sea buckthorn contained herbal tea with function of targeted repairing of blood vessels |
| CN106754136A (en) * | 2016-12-29 | 2017-05-31 | 甘肃滨河食品工业（集团）有限责任公司 | A kind of garlic health preserving wine and preparation method thereof |
| CN108117961A (en) * | 2018-01-26 | 2018-06-05 | 贵州理工学院 | A kind of minuent health preserving wine and preparation method thereof |
| CN109055141A (en) * | 2018-10-08 | 2018-12-21 | 浙江中医药大学 | A kind of blackberry, blueberry yellow rice wine and its preparation method and application |
| CN110144276A (en) * | 2019-05-15 | 2019-08-20 | 四川大学 | A preparation process of health wine with anti-fatigue function |
| CN114223895A (en) * | 2021-11-09 | 2022-03-25 | 上海椿龄健康管理有限公司 | Food formula for preventing and treating hyperlipidemia |
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