CN104856968B - A kind of Chinese medicinal tablet with eliminating thrombus and removing obstruction in channels effect and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine tablet with the effect of eliminating blood clots and dredging collaterals. The raw materials are 400-450 parts by weight of Astragalus, 250-300 parts by weight of Rhizoma Chuanxiong, 200-250 parts by weight of Salvia Miltiorrhiza, 130-160 parts by weight of Panax notoginseng, Alisma 130-160 parts by weight, 130-160 parts by weight of cassia twig, 130-160 parts by weight of turmeric, 130-160 parts by weight of hawthorn, 60-90 parts by weight of Sophora japonica, 60-90 parts by weight of woody fragrance, 5-8 parts by weight of borneol part; the present invention also provides a preparation method of the Chinese medicine tablet, which is simpler and more reasonable, and the content of active ingredients in the above-mentioned Chinese medicine tablet is higher.

Description

A traditional Chinese medicine tablet with the effect of eliminating blood clots and dredging collaterals and preparation method thereof

technical field

The invention relates to medicinal preparations in the field of medicine, in particular to a traditional Chinese medicine tablet with the effect of eliminating blood clots and dredging collaterals and a preparation method thereof.

Background technique

Xiaoshuan Tongluo Tablet is listed in the Chinese Pharmacopoeia. It is prepared from Rhizoma Chuanxiong, Salvia, Astragalus, Alisma, Panax notoginseng, Sophora japonica, Guizhi, Turmeric, Woody Fragrance, Borneol, and Hawthorn. It has the functions of promoting blood circulation, removing blood stasis, and warming meridians. It is clinically used to treat hyperlipidemia, stroke (cerebral thrombosis) recovery period (within one year) hemiplegia, numb limbs, cold hands and feet, slow speech, etc. It is a traditional Chinese medicine compound preparation for the treatment of cardiovascular diseases.

Stroke is one of the three major diseases leading to human death, the leading cause of disability due to disease, and a major public health burden worldwide. Long-term studies on the pathophysiology and prevention and treatment of stroke have shown that there are many risk factors and complex pathophysiological changes in such diseases, and it is difficult to obtain good therapeutic effects by using a single chemical or biological agent. However, Xiaoshuan Tongluo Tablet, a traditional Chinese medicine preparation characterized by comprehensive conditioning, has a good effect in the treatment of such diseases. But the technology of existing Xiaoshuan Tongluo Tablet is to continue to use the method of traditional decoction basically, and the raw material medicinal water other than Radix Notoginseng and Borneolum is decocted 3 times to extract. This method has a low extraction rate of active ingredients, and a large amount of water-soluble impurities is inevitably proposed. The effect of traditional Chinese medicine on disease prevention and treatment is directly related to the amount of extract and the content of active ingredients in it. If the extraction process is unreasonable and unscientific, it will inevitably cause damage and loss of active ingredients, thereby affecting the quality and curative effect of the preparation. In addition, the disintegration time of the existing Xiaoshuan Tongluo Tablet is relatively long, especially after long-term storage, it may exceed the pharmacopoeia standard. Too long disintegration time will seriously affect the absorption of the drug.

With the continuous improvement of drug quality and effect requirements in clinical practice and the continuous development of pharmaceutical technology, this technology can no longer meet the current needs. There is an urgent need for a preparation with more complete extraction of active ingredients and higher content to better play a role in the elimination of drugs. Medicinal value of classic formula of Shuan Tongluo.

Contents of the invention

The purpose of the present invention is to address the deficiencies in the prior art and provide a Xiaoshuan Tongluo Tablet with more complete extraction of active ingredients and a higher content, so as to better exert the medicinal value of the traditional prescription.

The invention provides a traditional Chinese medicine tablet with the effect of eliminating blood clots and dredging collaterals. The raw materials of the Chinese medicine tablet are: 400-450 parts by weight of Astragalus, 250-300 parts by weight of Rhizoma Chuanxiong, 200-250 parts by weight of Salvia Miltiorrhiza, 130-30 parts by weight of Panax notoginseng 160 parts by weight, 130-160 parts by weight of Alisma, 130-160 parts by weight of cassia twig, 130-160 parts by weight of turmeric, 130-160 parts by weight of hawthorn, 60-90 parts by weight of Sophora japonica, 60-90 parts by weight of woody fragrance , 5 to 8 parts by weight of borneol;

This Chinese medicine tablet is made by following preparation method:

(1) Take the raw materials other than the above-mentioned notoginseng and borneol, add 3 to 5 times the amount of warm water (distilled water) and 3 to 5% (based on the weight of medicinal materials) of compound enzymes, mix well, keep warm at 45 to 55 ° C for 1 to 2 hours; after adding water, extract twice by steam distillation, collect volatile oil, combine and concentrate the filtrate, add ethanol and let it stand overnight, filter, recover ethanol from the filtrate, concentrate to obtain extract, the extract density is 1.1-1.15 (50°C) ; The compound enzyme is a mixture of cellulase and pectinase;

(2) Crush notoginseng and borneol separately;

(3) Mix the extract obtained in step (2) with Panax notoginseng powder, granulate, and dry;

(4) Spray volatile oil on the granules obtained in step (3), add borneol powder and magnesium stearate, mix, compress into tablets, and coat with film to obtain final product.

The consumption of above-mentioned magnesium stearate is 1% (w/w), namely, magnesium stearate accounts for 1% of total tablet weight.

Ligusticum chuanxiong, turmeric, cassia twig and woody incense in the raw materials all contain a large amount of volatile active ingredients, and the method of direct water extraction in the existing technology will inevitably cause waste of these ingredients.

In recent years, people have continuously studied the application of enzymes in the extraction of traditional Chinese medicine, and achieved good results. The present invention adopts the advanced technology, and optimizes and improves the traditional decoction process according to the properties and characteristics of the active ingredients of each crude drug. A large number of experimental studies have been done on the selection of enzyme types and dosage. Finally, the above-mentioned preparation method and the tablet prepared by the method are obtained. The method has purified the extract, and in the case of reducing a large amount of impurities, the yield of the obtained extract (dry extract) is equivalent to that of the existing method, and more importantly, the content of astragaloside IV and rutin therein All have different degrees of improvement, that is, the content of the active ingredient in the preparation is increased, thereby improving its curative effect.

In order to reduce the amount of ineffective ingredients taken, the present invention introduces the step of alcohol precipitation to remove water-soluble impurities such as starch. The inventor investigates the concentrated density and alcohol concentration of the extract in the alcohol precipitation step, so as to take into account factors such as the amount of alcohol consumed in the alcohol precipitation process, the time for recovering ethanol, the loss of active ingredients, and finally determine that the extract is concentrated to a density of 1: (1~2)ml/g (that is, every 1~2g of raw medicinal material is concentrated to 1ml), add ethanol until the alcohol concentration is 50~60% (v/v).

The current extraction process is decocting three times in water, and the time spent in this step alone is 7 to 9 hours (including the time in the middle step), and the water consumption is 22 to 24 times the amount. Because the drug is used for a long time, and the number of people who use it is huge, the amount of electricity and water consumed for long-term production is astonishing. The optimized preparation method of the invention not only improves the extraction efficiency, but also saves a large amount of energy, and at the same time fully utilizes the increasingly scarce Chinese medicinal materials.

The raw materials for preparing 500 Chinese medicine tablets of the present invention are: Astragalus 428-435g, Rhizoma Chuanxiong 285-290g, Salvia miltiorrhiza 210-220g, Panax notoginseng 140-150g, Alisma 140-150g, Guizhi 140-150g, Curcuma 140-150g , hawthorn 140-150g, pagoda japonica 70-75g, woody fragrance 70-75g, borneol 5.5-6.0g; the unit weight of the traditional Chinese medicine tablet prepared by the method is 0.76g/piece.

The raw materials for preparing 500 tablets of this traditional Chinese medicine are preferably: Astragalus 431g, Chuanxiong 287g, Salvia miltiorrhiza 215g, Panax notoginseng 144g, Alisma 144g, Guizhi 144g, Curcuma 144g, Hawthorn 144g, Sophora japonica 72g, Woody 72g, Borneol 5.7g g; the unit dose of the Chinese medicine tablet is 0.76g/piece, that is, the specification of the Chinese medicine tablet (commonly known as "Xiaoshuan Tongluo Tablet") is 0.76g/piece.

The compound enzyme mentioned above is a 3:1 ratio of cellulase and pectinase. Plant tissue contains natural cellulase inhibitors; it protects plants from mold decay, so different botanicals or combinations require different enzymes and dosages. When the amount of enzyme is low, the effect of enzymatic hydrolysis is poor. As the concentration of enzyme increases, the contact area with the substrate increases, and the rate of enzymatic hydrolysis reaction increases, but the higher the better, when the enzyme reaches a certain concentration Inhibition will occur, and the enzyme will not be fully utilized, resulting in waste. Therefore, the inventors investigated the types and dosages of enzymes, and found that the effects were significantly different. Among them, the compound enzyme combined with cellulase and pectinase in a ratio of 3:1 has the best effect, which significantly improves the transfer rate of astragaloside IV, which is as high as 95.5%, which is 19% higher than that of the water extraction method.

In addition, the enzymatic hydrolysis temperature and enzymatic hydrolysis time also have a great influence on the enzymatic hydrolysis effect. The screening experiment results showed that the best enzymatic hydrolysis conditions were: 50°C, 1 hour.

Under the action of enzymes, not only the extraction effect is improved, but also the time and times of water extraction are significantly reduced. The extraction method of said step (1) is specifically: the first 8-10 times the amount of water extraction for 1 hour, the second 6-8 times the amount of water for 0.5 hours.

The step (1) is further as follows: the extraction filtrate is concentrated to 1: (1-2) ml/g, slowly adding ethanol under stirring until the alcohol concentration is 50% (v/v), and standing for 12-18 hours.

The step (3) is to mix the Panax notoginseng powder and the disintegrating agent, add it to the extract obtained in the step (2) to make a soft material, granulate, and dry. Wherein, the disintegrant is crospovidone and/or croscarmellose sodium. In a preferred embodiment, the disintegrating agent is crospovidone and croscarmellose sodium at a dosage ratio of 2:1, and the dosage is 2 to 5% (w/w), preferably 2 %.

Tablets with traditional Chinese medicine extracts as the main component generally take a long time to disintegrate due to the complexity and high viscosity of the extract. Especially after long-term storage, the disintegration time tends to continue to prolong obviously. Therefore, the present invention adds an appropriate amount of disintegrant, and the disintegration time of the tablet made after adding the disintegrant is about 15 minutes, and it also disintegrates completely in about 22 minutes after accelerated placement for 6 months. Effectively avoid the adverse effect of slow disintegration on the curative effect.

In the preparation method of the traditional Chinese medicine tablet of the invention, the extract extract is directly mixed with notoginseng powder and the like to granulate, which reduces the steps of drying and pulverizing the part of the extract, simplifies the process steps, and improves the production efficiency.

The inventor investigates the influence of different processing steps and parameters on the Chinese medicine tablet of the present invention by following tests.

Reiterate again: following test is just the exemplary test in numerous tests in the development process of the present invention, does not cover and exhaust all experiments that the inventor has done for the present invention, purpose is only to set forth Chinese medicine tablet preparation method of the present invention with those data Part of the process and results of screening optimization.

1. Screening experiment of enzyme type and dosage

1. Samples for testing: weigh Astragalus, Chuanxiong, Salvia, Alisma, Cinnamon Twig, Curcuma, Hawthorn, Sophora japonica and Muxiang according to the optimal raw material ratio of the above-mentioned Chinese medicine tablet, grind them into coarse particles, mix, weigh Mix raw material medicine 50g/ part, totally 30 parts.

2. Experimental method: taking the direct water decoction extraction method as a contrast, compare the influence of several enzymes and different dosages on the extraction of active ingredients from the crude drug of the present invention.

Among them, the water decoction method is: water decoction once, 10 times the amount of water decoction for 2 hours, and the filtrate is used to measure and calculate the transfer rate of astragaloside IV.

Enzymolysis method: add 4 times the amount of warm water to the mixed raw medicine, add the enzyme type and dosage in the water according to Table 1, mix well, keep warm at 45°C for 1.5 hours, add water to 8 times the amount, extract by steam distillation for 1 hour, and the filtrate , Determination and calculation of astragaloside IV transfer rate.

Astragaloside IV was determined according to the chromatographic conditions for the content determination of Astragalus membranaceus in the 2010 edition of "Chinese Pharmacopoeia".

Sample handling:

After the extract is filtered, accurately measure 2ml respectively, put it in a 50ml volumetric flask, add methanol to the mark, and filter through a microporous membrane (0.45μm) to obtain the product. Configure astragaloside IV reference solution about 60ug/ml.

3. Experimental results: The experimental data show that after enzymatic hydrolysis and then extraction, the transfer rate of astragaloside IV is significantly improved, and the difference between different enzyme species is obvious. Among them, the compound of cellulase and pectinase in a ratio of 3:1 The effect of the enzyme is the most significant, and the transfer rate of astragaloside IV has increased by 19%. % Enzymolysis efficiency is the highest. See Table 1 for details.

Table 1 Screening test results of enzyme types and dosage

Second, the investigation of enzymatic hydrolysis temperature

1. Test sample: Same as Experiment 1.

2. Experimental method: Based on the enzymatic hydrolysis method of Experiment 1, using 3:1 cellulase and pectinase as the compound enzyme, the effects of different enzymatic hydrolysis temperatures on the transfer rate of astragaloside IV were investigated according to Table 2.

3. Experimental results: The experimental data shows that the transfer rate of astragaloside IV increases continuously with the increase of temperature from 35°C to 50°C, and the downward trend is obvious when the temperature reaches 60°C. All have good enzymatic hydrolysis effects, among which 50°C is the best. See Table 2 for details.

Table 2 The investigation results of enzymatic hydrolysis temperature

Group No Enzyme temperature Transfer rate of astragaloside IV% 1 35°C 85.5 2 40℃ 91.4 3 45°C 94.7 4 50℃ 96.2 5 55°C 95.1 6 60℃ 92.9

3. Investigation of enzymatic hydrolysis time

1. Test sample: Same as Experiment 1.

2. Experimental method: Based on the enzymatic hydrolysis method of Experiment 1, using 3:1 cellulase and pectinase as the compound enzyme and 50°C as the enzymatic hydrolysis temperature, the effect of enzymatic hydrolysis time on the extraction was investigated.

3. Experimental results: Experimental data show that under the same conditions, there is no significant difference in the transfer rate of astragaloside IV within 1 to 2 hours of enzymatic hydrolysis. In order to improve production efficiency and save time, 1 hour of enzymatic hydrolysis is preferred. See Table 3 for details.

Table 3 Investigation results of enzymatic hydrolysis temperature

Group No Enzymolysis time Transfer rate of astragaloside IV% 1 0.5 hours 91.6 2 1 hour 96.1 3 1.5 hours 96.5 4 2 hours 96.2

4. Selection of disintegrants in tablets

Mix the extract obtained in step (1) of the present invention with Panax notoginseng powder, add 2% (w/w) of different disintegrants to granulate, and dry; spray volatile oil to the granules, mix with borneol, add magnesium stearate, mix and press Tablets, film-coated, and tested for disintegration time according to the Pharmacopoeia method. The results show that both crospovidone and croscarmellose sodium can significantly accelerate the disintegration speed, especially when the two are combined at a ratio of 2:1, the disintegration time is significantly shortened. See Table 4 for details.

Table 4 Selection results of disintegrants

Group No disintegrant Disintegration time (min) 1 —— 23.5 2 Sodium carboxymethyl starch 22.6 3 Croscarmellose Sodium 19.1 4 Low-substituted hydroxypropyl cellulose 20.5 5 Crospovidone 17.8 6 Crospovidone + Croscarmellose Sodium (1:1) 17.2 7 Crospovidone + Croscarmellose Sodium (2:1) 15.3 8 Crospovidone + Croscarmellose Sodium (1:2) 19.4

specific implementation plan

Example 1

500 tablet prescription:

Astragalus 431g, Chuanxiong 287g, Salvia 215g, Panax notoginseng 144g, Alisma 144g, Guizhi 144g, Curcuma 144g, Hawthorn 144g, Sophora japonica 72g, Woody 72g, Borneol 5.7g; Crospovidone 5g, Croscarboxyl Sodium methylcellulose 2.5g, magnesium stearate 3.8g.

Preparation:

(1) Take the above-mentioned raw materials except Sanqi and Borneol, add 3 times the amount of warm water and 4% compound enzyme (3:1 cellulase and pectinase, the same below), mix well, keep warm at 50°C for enzymatic hydrolysis for 1 Add distilled water to 8 times the amount, extract 2 times by steam distillation, collect volatile oil, the first time for 1 hour, add 6 times the amount of water for 0.5 hours for the second time, combine the decoction, filter, and concentrate the filtrate under reduced pressure to 1 : After 1.5ml/g, add ethanol to alcohol concentration 50%, leave standstill for 12 hours, filter, the filtrate reclaims ethanol, concentrates to obtain extract, extract density 1.13 (50 ℃);

⑵ Crush notoginseng and borneol to 100 mesh respectively, and set aside;

(3) mix crospovidone, croscarmellose sodium and notoginseng powder, add to the extract obtained in step (2) to make a soft material, granulate, and dry;

(4) Spray volatile oil into the granules obtained in step (3), add borneol powder and magnesium stearate, mix well, press into tablets, and coat with film to obtain final product. The unit weight of the traditional Chinese medicine tablet prepared by the above method is 0.76g/tablet (that is, the specification is 0.76g/tablet).

Example 2

500 tablet prescription:

Astragalus 431g, Chuanxiong 287g, Salvia miltiorrhiza 215g, Panax notoginseng 144g, Alisma 144g, Guizhi 144g, Curcuma 144g, Hawthorn 144g, Sophora japonica 72g, Woody fragrance 72g, Borneol 5.7g; Cross-linked povidone 3.8g, cross-linked Carboxymethylcellulose sodium 3.8g, magnesium stearate 3.8g.

The difference between the preparation method and Example 1 is:

⑴ Take the above raw materials except Sanqi and Borneol, add 5 times the amount of warm water and 3% compound enzyme, mix well, keep warm at 45°C for 1.5 hours; add distilled water to 10 times the amount, and extract 2 The first time, collect the volatile oil, add 6 times the amount of water for the second time, combine the decoction, filter, add ethanol to the alcohol concentration of 60% after the filtrate is concentrated to 1:1ml/g, let it stand for 14 hours, filter, recover the ethanol from the filtrate, concentrate, Obtained extract, extract density 1.1 (50 ℃).

Example 3

500 tablet prescription:

Astragalus 431g, Chuanxiong 287g, Salvia 215g, Panax notoginseng 144g, Alisma 144g, Guizhi 144g, Curcuma 144g, Hawthorn 144g, Sophora japonica 72g, Woody 72g, Borneol 5.7g; Crospovidone 7.6g, stearin Magnesium acid 3.8g.

The difference between the preparation method and Example 1 is:

(1) Take the above-mentioned raw materials except Sanqi and Borneol, add 4 times the amount of warm water and 5% compound enzyme, mix well, keep warm at 55°C for 2 hours; add distilled water to 8 times the amount, and extract 2 The first time, collect the volatile oil, add 8 times the amount of water for the second time, combine the decoction, filter, add ethanol to the alcohol concentration of 55% after the filtrate is concentrated to 1:2ml/g, let it stand for 18 hours, filter, recover the ethanol from the filtrate, concentrate, Obtained extract, extract density 1.15 (50 ℃).

Example 4

500 tablet prescription:

Astragalus 400g, Chuanxiong 300g, Salvia miltiorrhiza 200g, Panax notoginseng 160g, Alisma 160g, Guizhi 130g, Curcuma 160g, Hawthorn 130g, Sophora japonica 60g, Muxiang 90g, Borneol 5g; Magnesium stearate 3.8g.

The preparation method is the same as any method in Examples 1-3.

Example 5

500 tablet prescription:

Astragalus 450g, Chuanxiong 250g, Salvia miltiorrhiza 250g, Panax notoginseng 130g, Alisma 130g, Guizhi 160g, Curcuma 130g, Hawthorn 160g, Sophora japonica 90g, Woody fragrance 60g, Borneol 8g; Croscarmellose sodium 7.6g, Magnesium stearate 3.8g.

The preparation method is the same as any method in Examples 1-3.

Example 6

The 500-tablet prescription is:

Astragalus 428g, Chuanxiong 285g, Salvia 210g, Sanqi 140g, Alisma 140g, Guizhi 140g, Curcuma 140g, Hawthorn 140g, Sophora japonica 70g, Woody Fragrance 70g, Borneol 5.5g; appropriate amount of disintegrating agent, the dosage ratio is 2:1 combination of crospovidone and croscarmellose sodium.

The preparation method is the same as any method in Examples 1-3.

Example 7

The 500-tablet prescription is:

Astragalus 429g, Chuanxiong 288g, Salvia miltiorrhiza 217g, Panax notoginseng 147g, Alisma 147g, Guizhi 137g, Curcuma 149g, Hawthorn 145g, Sophora japonica 72g, Woody fragrance 72g, Borneol 5.7g; appropriate amount of disintegrating agent, the dosage ratio is 2:1 combination of crospovidone and croscarmellose sodium.

The preparation method is the same as any method in Examples 1-3.

The above is intended to further illustrate the present invention, but not to limit the scope of the present invention. Modifications and changes to the embodiments disclosed herein may be made by those skilled in the art without departing from the scope and spirit of the invention.

Claims (3)

1. A Chinese medicine tablet with the effect of eliminating blood clots and dredging collaterals, characterized in that the raw materials for preparing 500 pieces of this Chinese medicine tablet are: Radix Astragali 431g, Rhizoma Chuanxiong 287g, Salvia miltiorrhiza 215g, Panax notoginseng 144g, Alisma 144g, cassia twig 144g , turmeric 144g, hawthorn 144g, Sophora japonica 72g, woody fragrance 72g, borneol 5.7g; the unit weight of the traditional Chinese medicine tablet is 0.76g/piece; This Chinese medicine tablet is made by following preparation method: (1) Take the raw materials other than the above-mentioned notoginseng and borneol, add 3 to 5 times the amount of warm water and 3 to 5% compound enzyme, mix well, keep warm at 45 to 55°C for 1 to 2 hours; Distillation extraction twice, the first 8 to 10 times the amount of water extraction for 1 hour, the second 6 to 8 times the amount of water for 0.5 hours; collect volatile oil, combine and concentrate the filtrate, add ethanol and let stand overnight, filter, recover ethanol from the filtrate, concentrate, To obtain the extract, the density of the extract is 1.1 to 1.15 at 50°C; the compound enzyme is 3:1 cellulase and pectinase; the enzymolysis temperature is 50°C, and the enzymolysis time is 1 hour; (2) Crush notoginseng and borneol separately; (3) Mix the extract obtained in step (2) with Panax notoginseng powder, granulate, and dry; (4) spray volatile oil to the granules obtained in step (3), add borneol powder and magnesium stearate, mix, compress into tablets, coat with film, to obtain final product; The step (1) is to concentrate the extraction filtrate to 1: (1-2) ml/g, slowly add ethanol under stirring until the alcohol concentration is 50% (v/v), and let stand for 12-18 hours; The step (3) is to mix the Panax notoginseng powder and the disintegrating agent, add it to the extract obtained in the step (2) to make a soft material, granulate, and dry; The disintegrant is a 2:1 combination of crospovidone and croscarmellose sodium. 2. Chinese medicine tablet as claimed in claim 1, is characterized in that, the consumption of described disintegrant is 2～3%, and the consumption of magnesium stearate is 1%. 3. Chinese medicine tablet as claimed in claim 1, is characterized in that, the raw material of preparing 500 this Chinese medicine tablet is: Astragalus 431g, Chuanxiong 287g, Salvia 215g, Panax notoginseng 144g, Alisma 144g, Guizhi 144g, Curcuma 144g, Hawthorn 144g, Sophora japonica 72g, Woody 72g, Borneol 5.7g; Crospovidone 5g, Croscarboxyl Sodium methylcellulose 2.5g, magnesium stearate 3.8g; Preparation: (1) Take the above-mentioned raw materials except Panax notoginseng and borneol, add 3 times the amount of warm water and 4% compound enzyme, the compound enzyme is 3:1 cellulase and pectinase, mix well, and keep warm at 50°C Enzyme hydrolysis for 1 hour; add distilled water to 8 times the amount, extract 2 times with steam distillation, collect volatile oil, the first time for 1 hour, add 6 times the amount of water for 0.5 hours for the second time, combine the decoction, filter, and decompress the filtrate After concentrating to 1:1.5ml/g, add ethanol to the alcohol concentration of 50%, let it stand for 12 hours, filter, recover ethanol from the filtrate, concentrate to obtain extract, and the density of the extract is 1.13 at 50°C; ⑵ Crush notoginseng and borneol to 100 mesh respectively, and set aside; (3) mix crospovidone, croscarmellose sodium and notoginseng powder, add to the extract obtained in step (2) to make a soft material, granulate, and dry; (4) spray volatile oil in step (3) gained granule, add borneol powder and magnesium stearate, mix, tabletting, film coating, to obtain final product; The unit weight of this Chinese medicine tablet that aforesaid method makes is 0.76g/ piece, That is, the specification is 0.76g/piece.