CN104825248B - A kind of retinal prosthesis system - Google Patents
A kind of retinal prosthesis system Download PDFInfo
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- CN104825248B CN104825248B CN201510268494.6A CN201510268494A CN104825248B CN 104825248 B CN104825248 B CN 104825248B CN 201510268494 A CN201510268494 A CN 201510268494A CN 104825248 B CN104825248 B CN 104825248B
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Abstract
The invention discloses a kind of retinal prosthesis system, including outer body and implant part, wherein, outer body, including portable power source, vision glasses and transmission coil, portable power source is connected with vision glasses, provides external power source to power for whole retinal prosthesis system；Vision glasses, including pick-up lens, mainboard and interface board；Transmission coil is connected with rf modulations module, is used for receiving image coding signal；Implant part, including receiving coil, demodulated stimulus module and stimulating electrode, receiving coil is connected in the heart with described transmission coil；Demodulated stimulus module is connected with described receiving coil, is decoded by the image coding signal received of described receiving coil, and is converted into the signal of telecommunication to stimulating electrode transmission；Described stimulating electrode includes several contact electrode and the wire electrode being connected one by one with contact electrode.The present invention can directly stimulate the retinal ganglial cells of innermost layer, electronic device major part part in vitro, and image procossing aspect updates easily.
Description
Technical field
The invention belongs to medical instruments field, particularly to a kind of retinal prosthesis system.
Background technology
Recently as the continuous progress of science and technology, create artificial retina recovery technique, i.e. directly light is believed
Number it is changed into the signal of telecommunication, recycles stimulating electrical signal retinochrome cell, can recover to a certain extent
The vision of patient, this technology now has become as vision and repairs the study hotspot in field at present.Retina electrostimulation
Mode with place stimulating electrode position difference be divided into two classes.One class is to produce micro-electric current with photosensitive diode
The wafer heeling-in stimulated, at photoreceptor layer, claims to implant (Sub-retina implant) under retina, its electricity irritation
Object based on bipolar cell；Another kind of transmission for radio-frequency current stimulates signal to planting in retina top layer
The electrod-array of micro-electrical stimulation, claims retinal surface to implant (Epi-retina implant), the object of its electricity irritation
Based on ganglionic cell.
The technical scheme implanted under retina make use of the retinal neural network still with partial function, uses
The low-light point diode in place photoreceptor cell，photosensory cell of damaged.Need not external image collecting device, eyeball can be lived
Move freely, and target is positioned.But owing to general incident ray is not enough to activate photodiode, so
Need the energy that extra light source amplification system offer is enough.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of ganglionic cell and aixs cylinder thereof of directly stimulating, no
Needing the neutral net of retinal photoreceptor, i.e. need not complete retina, external information collecting device is more square
It is easy to the retinal prosthesis system of external control.
To achieve these goals, technical scheme is as follows: a kind of retinal prosthesis system, including
Outer body and implant part, wherein,
Described outer body, including portable power source, vision glasses and transmission coil, wherein,
Described portable power source is connected with described vision glasses, provides external power source for whole retinal prosthesis system
Power supply；
Described vision glasses, including pick-up lens, mainboard and interface board, wherein,
Described pick-up lens is used for gathering extraneous image, and the signal of video signal collected is input to described mainboard；
Described mainboard is attached by interface board interface and mainboard interface with described interface board；Described mainboard bag
Include imageing sensor, DSP module, rf modulations module, power module, interface board interface, DDR2 mould
Block and Flash module；Described interface board includes mainboard interface, power input interface, TV output module and sound
Frequently output module；Described imageing sensor is connected with described pick-up lens, is used for the shadow gathering pick-up lens
As information carries out coupling and preliminary images signal processing, after process, it is output as data image signal, inputs institute
State DSP module；Described DSP module is used for processing the data image signal of input, encode sum
Word, the image coding signal output of described DSP module is connected with described rf modulations module；Described
DDR2 module and Flash module are connected with described DSP module, are used for the data in described DSP module
Store, prevent loss；Described interface board interface and described power module and described DSP module difference
Connect, be used for passing sequentially through the energy of described portable power source power input interface and the mainboard of described interface board
Interface is sent to described power module, and output image signal and the control signal of described DSP module is led to
The mainboard interface crossing described interface board is sent to described TV output module and dio Output Modules；Described TV
Output module is used for showing the video image after described DSP module processes；Described dio Output Modules
It is used for carrying out voice message；
Described transmission coil is connected with described rf modulations module, is used for receiving image coding signal；
Described implant part, including receiving coil, demodulated stimulus module and stimulating electrode, wherein,
Described receiving coil is connected in the heart with described transmission coil, receives the image volume that described transmission coil is launched
Code signal；There is Magnet at the center of described receiving coil and transmission coil, and Magnet is passed through in being connected in the heart of the two
Attracting, the Magnet of described transmission coil can adjust magnetic by changing model；
Described demodulated stimulus module is connected with described receiving coil, by the image received of described receiving coil
Coding signal is decoded, and is converted into the signal of telecommunication and transmits to described stimulating electrode；
Described stimulating electrode includes several contact electrode and the wire electrode being connected one by one with contact electrode, described
Contact electrode at least half surface area exposure is outside packaging silicon rubber, and described wire electrode is wrapped in packaging silicon rubber
In, described contact electrode is used for stimulating optic nerve.
Alternatively, described pick-up lens is for focusing or autofocus lens.
Alternatively, integrated image signal processing function in described imageing sensor, generally OV7740 or
OV7670 or OV3640 or OV9712.
Alternatively, described DSP module low-power consumption, lowest power consumption is 0.5-0.8W.
Alternatively, described interface board interface is connected by flexible flat cable with mainboard interface.
Alternatively, described TV output module also shows the video image collected from described pick-up lens.
Alternatively, it is shaped as flat elliptic after the encapsulation of described stimulating electrode.
Alternatively, the contact electrode rectangular array arrangement of described stimulating electrode.
Alternatively, the contact electrode number of described stimulating electrode is 24-256, and the rectangular array of arrangement is
4*6 or 6*6 or 6*8 or 8*8 or 16*16.
The beneficial effects of the present invention is: implant part can avoid most retina, it is only necessary to by thorn
The retinal ganglial cells swashing internal layer realizes producing the effect of vision, so the artificial retina of the present invention
As long as system can give all member-retaining portion retinal ganglial cells functions and the normal view of pathway
Membrane disease patient such as retinitis pigmentosa, ocular injury etc. provide the perception of vision.Most electronic device
It is in vitro in part, so makes implant part the least, the image of renewal in the future, usually outer body
Renewal in terms of process, is also easier, and doctor can be by the method regulating outer body image processor
Find out the image processing method adapting to each patient.Implanting portion due to the retinal prosthesis system of the present invention
Point be integrally fixed on retina, vitreous body both can as the supporter of implant part, again can as radiator,
And less for the impact of amphiblestroid blood supply, it is also easy to from eye observe simultaneously.
Accompanying drawing explanation
Fig. 1 is the entire block diagram of retinal prosthesis system of the present invention；
Fig. 2 is the outer body block diagram of retinal prosthesis system of the present invention；
Fig. 3 is the outer body structural representation of retinal prosthesis system of the present invention；
Fig. 4 is the structural representation of retinal prosthesis system of the present invention；
Detailed description of the invention
Below in conjunction with accompanying drawing, the preferred embodiments of the present invention are described in detail.
See Fig. 1-Fig. 2, the overall and outer body block diagram for retinal prosthesis system, a kind of artificial retina
System, including outer body 10 and implant part 20, wherein,
Described outer body 10, including portable power source 110, vision glasses 120 and transmission coil 140, its
In,
Described portable power source 110 is connected with described vision glasses 120, provides for whole retinal prosthesis system
External power source is powered；
Described vision glasses 120, including pick-up lens 121, mainboard 122 and interface board 131, wherein,
Described pick-up lens 121 is used for gathering extraneous image, and the signal of video signal collected is input to described master
Plate 122；
Described mainboard 122 is carried out by interface board interface 127 and mainboard interface 132 with described interface board 131
Connect；Described mainboard 122 include imageing sensor 123, DSP module 124, rf modulations module 125,
Power module 126, interface board interface 127, DDR2 module 128 and Flash module 129；Described interface
Plate 131 includes mainboard interface 132, power input interface 133, TV output module 134 and audio frequency output mould
Block 135；Described imageing sensor 123 is connected with described pick-up lens 121, is used for pick-up lens 121
The image information gathered carries out coupling and preliminary images signal processing, is output as digital picture letter after process
Number, input described DSP module 124；Described DSP module 124 is used for the data image signal to input
Carrying out processing, encoding and digitized, the image coding signal output of described DSP module 124 is penetrated with described
Frequently modulation module 125 connects；Described DDR2 module 128 and Flash module 129 and described DSP module
124 connect, and are used for storing the data in described DSP module 124, prevent loss；Described interface
Plate 131 interface is connected respectively with described power module 126 and described DSP module 124, is used for described
The energy of portable power source 110 passes sequentially through power input interface 133 and the mainboard interface of described interface board 131
132 are sent to described power module 126, and by the output image signal of described DSP module 124 and control
Signal is sent to described TV output module 134 and audio frequency by the mainboard interface 132 of described interface board 131
Output module 135；Described TV output module 134 is used for showing after described DSP module 124 processes
Video image；Described dio Output Modules 135 is used for carrying out voice message；
Described transmission coil 140 is connected with described rf modulations module 125, is used for receiving image coding signal；
Described implant part 20, including receiving coil 210, demodulated stimulus module 220 and stimulating electrode 230,
Wherein,
Described receiving coil 210 is connected in the heart with described transmission coil 140, receives described transmission coil 140
The image coding signal launched；There is Magnet at the center of described receiving coil 210 and transmission coil 140, and two
Being connected in the heart of person is attracting by Magnet, and the Magnet of described transmission coil 140 can regulate by changing model
Magnetic；
Described demodulated stimulus module 220 is connected with described receiving coil 210, is connect by described receiving coil 210
The image coding signal received is decoded, and is converted into the signal of telecommunication and transmits to described stimulating electrode 230；
Described stimulating electrode 230 includes several contact electrode and the wire electrode being connected one by one with contact electrode,
Described contact electrode at least half surface area exposure is outside packaging silicon rubber, and described wire electrode is wrapped in encapsulation silicon
In glue, described contact electrode is used for stimulating optic nerve.
Seeing Fig. 3-4, indicate the structure of retinal prosthesis system, pick-up lens 121 is positioned at vision glasses
120 foremost, is also corresponding with the position of human eye simultaneously, and the angle seen with eyes is consistent, main
Plate 122 is at the rear of pick-up lens 121, and transmission coil 140 is connected with mainboard 122, portable power source 110
By power input interface 133, by power injection interface plate 131, transmission coil 140 and receiving coil 210
Attracting, the skin of human body simulated by middle dividing plate 150, and receiving coil 210 will receive image coding signal
It is transferred to demodulated stimulus module 220 be decoded, and is converted into the signal of telecommunication and transmits to described stimulating electrode 230,
Finally directly retinal ganglial cells is carried out electricity irritation by stimulating electrode 230.
Further, described pick-up lens 121 is for focusing or autofocus lens.
Further, integrated image signal processing function, generally OV7740 in described imageing sensor 123
Or OV7670 or OV3640 or OV9712.
Further, the low-power consumption of described DSP module 124, lowest power consumption is 0.5-0.8W.
Further, described interface board interface 127 is connected by flexible flat cable with mainboard interface 132.
Further, described TV output module 134 also shows from regarding that described pick-up lens 121 collects
Frequently image.
Further, it is shaped as flat elliptic after the encapsulation of described stimulating electrode 230.
Further, the contact electrode rectangular array arrangement of described stimulating electrode 230.
Further, the contact electrode number of described stimulating electrode 230 is 24-256, the rectangle of arrangement
Array is 4*6 or 6*6 or 6*8 or 8*8 or 16*16.
Finally illustrate, preferred embodiment above only in order to technical scheme to be described and unrestricted,
Although the present invention being described in detail by above preferred embodiment, but those skilled in the art
Should be appreciated that and in the form and details it can be made various change, without departing from the present invention
Claims limited range.
Claims (9)
1. a retinal prosthesis system, it is characterised in that include outer body and implant part, wherein,
Described outer body, including portable power source, vision glasses and transmission coil, wherein,
Described portable power source is connected with described vision glasses, provides external power source for whole retinal prosthesis system
Power supply；
Described vision glasses, including pick-up lens, mainboard and interface board, wherein,
Described pick-up lens is used for gathering extraneous image, and the signal of video signal collected is input to described mainboard；
Described mainboard is attached by interface board interface and mainboard interface with described interface board；Described mainboard bag
Include imageing sensor, DSP module, rf modulations module, power module, interface board interface, DDR2 mould
Block and Flash module；Described interface board includes mainboard interface, power input interface, TV output module and sound
Frequently output module；Described imageing sensor is connected with described pick-up lens, is used for the shadow gathering pick-up lens
As information carries out coupling and preliminary images signal processing, after process, it is output as data image signal, inputs institute
State DSP module；Described DSP module is used for processing the data image signal of input, encode sum
Word, the image coding signal output of described DSP module is connected with described rf modulations module；Described
DDR2 module and Flash module are connected with described DSP module, are used for the data in described DSP module
Store, prevent loss；Described interface board interface and described power module and described DSP module difference
Connect, be used for passing sequentially through the energy of described portable power source power input interface and the mainboard of described interface board
Interface is sent to described power module, and output image signal and the control signal of described DSP module is led to
The mainboard interface crossing described interface board is sent to described TV output module and dio Output Modules；Described TV
Output module is used for showing the video image after described DSP module processes；Described dio Output Modules
It is used for carrying out voice message；
Described transmission coil is connected with described rf modulations module, is used for receiving image coding signal；
Described implant part, including receiving coil, demodulated stimulus module and stimulating electrode, wherein,
Described receiving coil is connected in the heart with described transmission coil, receives the image volume that described transmission coil is launched
Code signal；
Described demodulated stimulus module is connected with described receiving coil, by the image received of described receiving coil
Coding signal is decoded, and is converted into the signal of telecommunication and transmits to described stimulating electrode；
Described stimulating electrode includes several contact electrode and the wire electrode being connected one by one with contact electrode, described
Contact electrode at least half surface area exposure is outside packaging silicon rubber, and described wire electrode is wrapped in packaging silicon rubber
In, described contact electrode is used for stimulating optic nerve.
Retinal prosthesis system the most according to claim 1, it is characterised in that described pick-up lens
For focusing or autofocus lens.
Retinal prosthesis system the most according to claim 1, it is characterised in that described image sensing
Integrated image signal processing function in device.
Retinal prosthesis system the most according to claim 1, it is characterised in that described DSP module
Lowest power consumption is 0.5-0.8W.
Retinal prosthesis system the most according to claim 1, it is characterised in that described interface board connects
Mouth is connected by flexible flat cable with mainboard interface.
6. according to the retinal prosthesis system one of claim 1-5 Suo Shu, it is characterised in that described TV
Output module also shows the video image collected from described pick-up lens.
Retinal prosthesis system the most according to claim 6, it is characterised in that described stimulating electrode
Encapsulation after be shaped as flat elliptic.
Retinal prosthesis system the most according to claim 6, it is characterised in that described stimulating electrode
Contact electrode rectangular array arrangement.
Retinal prosthesis system the most according to claim 8, it is characterised in that described stimulating electrode
Contact electrode number be 24-256.
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| CN201510268494.6A CN104825248B (en) | 2015-05-25 | 2015-05-25 | A kind of retinal prosthesis system |
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Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105498088B (en) * | 2016-01-05 | 2018-04-03 | 浙江诺尔康神经电子科技股份有限公司 | One kind listening property brain stem stimulating system |
| CN106267556B (en) * | 2016-08-22 | 2018-04-10 | 深圳硅基仿生科技有限公司 | The implanted device and artificial retina of artificial retina without bandage |
| CN107398012B (en) * | 2016-09-30 | 2018-10-12 | 深圳硅基仿生科技有限公司 | The charge compensating circuit and method of nerve stimulation and retinal prosthesis system |
| CN109701157B (en) * | 2017-12-29 | 2020-07-28 | 深圳硅基仿生科技有限公司 | Radio frequency signal detection device with detection coil and retina stimulator |
| CN109157738B (en) * | 2018-07-23 | 2022-02-15 | 浙江诺尔康神经电子科技股份有限公司 | Artificial retina amplitude modulation control method and system based on depth vision |
| CN109248378B (en) * | 2018-09-09 | 2020-10-16 | 深圳硅基仿生科技有限公司 | Video processing device and method of retina stimulator and retina stimulator |
| CN109568790A (en) * | 2018-11-26 | 2019-04-05 | 中山大学中山眼科中心 | Optical rehabilitation device |
| CN109711286B (en) * | 2018-12-11 | 2022-11-11 | 中国科学院深圳先进技术研究院 | A control method and device based on artificial retinal spatial perception |
| CN111064880A (en) * | 2020-03-17 | 2020-04-24 | 深圳市中科先见医疗科技有限公司 | Image acquisition device and artificial retina in-vitro device |
| CN111938625B (en) * | 2020-08-10 | 2024-08-02 | 中国科学院上海微系统与信息技术研究所 | Nerve imaging system with photoelectric stimulation and recording functions and preparation method thereof |
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| US6458157B1 (en) * | 1997-08-04 | 2002-10-01 | Suaning Gregg Joergen | Retinal stimulator |
| EP1171188B1 (en) * | 1999-03-24 | 2009-05-06 | Second Sight Medical Products, Inc. | Retinal color prosthesis for color sight restoration |
| US6427087B1 (en) * | 2000-05-04 | 2002-07-30 | Optobionics Corporation | Artificial retina device with stimulating and ground return electrodes disposed on opposite sides of the neuroretina and method of attachment |
| US6970745B2 (en) * | 2000-08-09 | 2005-11-29 | The United States Of America As Represented By The Secretary Of The Navy | Microelectronic stimulator array for stimulating nerve tissue |
| JP4138407B2 (en) * | 2002-08-30 | 2008-08-27 | 株式会社ニデック | Intraocular implant device |
| CN100586403C (en) * | 2008-03-06 | 2010-02-03 | 上海交通大学 | Visual prosthesis image processing device and method |
| US20120116507A1 (en) * | 2009-04-27 | 2012-05-10 | David Chee Keong Ng | Retinal prosthesis |
| CN104013491B (en) * | 2014-05-23 | 2016-03-23 | 浙江诺尔康神经电子科技股份有限公司 | A kind of folding Wicresoft artificial retina microelectrode array |
| CN204734580U (en) * | 2015-05-25 | 2015-11-04 | 浙江诺尔康神经电子科技股份有限公司 | Artificial retina system |
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