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CN107398012B - The charge compensating circuit and method of nerve stimulation and retinal prosthesis system - Google Patents

The charge compensating circuit and method of nerve stimulation and retinal prosthesis system Download PDF

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Publication number
CN107398012B
CN107398012B CN201710814549.8A CN201710814549A CN107398012B CN 107398012 B CN107398012 B CN 107398012B CN 201710814549 A CN201710814549 A CN 201710814549A CN 107398012 B CN107398012 B CN 107398012B
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charge
pulse current
electric charge
current signal
total amount
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CN107398012A (en
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夏斌
林郁
方贤文
陈志�
赵瑜
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Shenzhen Silicon Bionics Technology Co.,Ltd.
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Shenzhen Sibionics Technology Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36057—Implantable neurostimulators for stimulating central or peripheral nerve system adapted for stimulating afferent nerves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/36046—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of the eye
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting in contact-lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/08—Devices or methods enabling eye-patients to replace direct visual perception by another kind of perception
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36128—Control systems
    • A61N1/36142—Control systems for improving safety
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/02—Details
    • A61N1/04—Electrodes
    • A61N1/05—Electrodes for implantation or insertion into the body, e.g. heart electrode
    • A61N1/0526—Head electrodes
    • A61N1/0543—Retinal electrodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00—Electrotherapy; Circuits therefor
    • A61N1/18—Applying electric currents by contact electrodes
    • A61N1/32—Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36—Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3605—Implantable neurostimulators for stimulating central or peripheral nerve system
    • A61N1/36125—Details of circuitry or electric components

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Ophthalmology & Optometry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Prostheses (AREA)
  • Electrotherapy Devices (AREA)

Abstract

It is the charge compensating circuit for carrying out charge compensation to pulse current generation circuit the present invention provides a kind of charge compensating circuit of nerve stimulation, pulse current generation circuit generates the Bipolar pulse current for nerve stimulation, and charge compensating circuit includes：Detection circuit is used to detect the total amount of electric charge in a stimulation period of the Bipolar pulse current signal generated by pulse current generation circuit；Decision circuitry is used to judge whether the total amount of electric charge detected by detection circuit to be more than safe charge amount；And compensation circuit, it is used for when decision circuitry judges that total amount of electric charge is more than safe charge amount, generates the compensated pulse current signal with net charge amount so that total amount of electric charge is within safe charge amount.In accordance with the invention it is possible in the case where not utilizing the larger bulky capacitor of footprint area, in a limited space in fully improve charge balance ability.In addition, the present invention also provides charge compensation method and retinal prosthesis systems.

Description

The charge compensating circuit and method of nerve stimulation and retinal prosthesis system
The application isOn 09 30th, 2016, application No. is201610875326.8, it is entitledCharge Compensation circuit, charge compensation method and retinal prosthesis systemPatent application divisional application.
Technical field
The present invention relates to nerve stimulation fields, and in particular to the charge compensating circuit and method of nerve stimulation and manually regards Nethike embrane system.
Background technology
In nerve stimulation field, providing electro photoluminescence by stimulating electrode can make nerve fiber generate reaction, to obtain Obtain desired function.Such as in the eyesight repair system of existing artificial retina, in order to give blind person restore visual experience, one As need to be put into implant in the eyeball of blind person, such implant is instead of for example because of retinal pigment degeneration (RP) or old The function of year macular degeneration (AMD) etc. and impaired photosensory cell, in the case where other functions of pathways for vision obtain reservation, Stimulation can be generated to allow blind person to retain intact other nerve pathways to retina by the stimulating electrode in implant Recovered part eyesight.In retinal prosthesis system, external camera captured video image, then image processing apparatus will regard Frequency image is converted into electric signal and is sent to implant, and then, the implant positioned at intraocular converts electrical signals to stimulus signal, And the gangliocyte of retina is stimulated by the stimulating electrode of implant, thus enable blind person on cerebral cortex Experience light sensation, recovered part eyesight.
Invention content
It is generated for nerve stimulation however, in existing nerve stimulation device such as retinal prosthesis system Stimulated current is likely to it cannot be guaranteed that stimulate in the period that the quantity of electric charge is within safe charge amount at one, the nerve fiber that is stimulated (such as the gangliocyte of retina or Beale's ganglion cells) it is therefore possible to there are net charges such as positive charge or negative electrical charges, lead to god Gangliocyte or Beale's ganglion cells through organizing such as retina are damaged.
In order to which what the gangliocyte or Beale's ganglion cells that ensure nerve fiber such as retina were received stimulates the flat of charge Weighing apparatus property also has consideration in pulse current generation circuit and is stimulated between position RC circuits are arranged, with equilibrium nerve ganglion cell or Extra charge on Beale's ganglion cells.However, the capacity positive correlation of the charge balance performance of RC circuits and the capacitance in RC circuits, is Balance more positive charge or negative electrical charge, need, by the capacity boost of the capacitance in RC circuits, thus to need greater area of Capacitance.However, in nerve stimulation field, circuit design space tends to be limited, can not integrate area occupy it is larger big Therefore capacitance can not be played fully using RC circuits come balancing charge ability.
The present invention is made in view of above-mentioned situation, and its purpose is to provide one kind can be interior in a limited space Charge compensating circuit, charge compensation method and the retinal prosthesis system of charge balance ability can be improved.
For this purpose, the first aspect of the present invention provides a kind of charge compensating circuit, it is for generating electricity to pulse current Road carries out the charge compensating circuit of charge compensation, and the pulse current generation circuit generates the two--way pulse for nerve stimulation Stream, the charge compensating circuit include：Detection circuit is used to detect described pair generated by the pulse current generation circuit Total amount of electric charge into a stimulation period of pulsed current signal；Decision circuitry is used to judge to be examined by the detection circuit Whether the total amount of electric charge surveyed is more than safe charge amount；And compensation circuit, it is used to work as described in decision circuitry judgement When total amount of electric charge is more than safe charge amount, the compensated pulse current signal with net charge amount is generated so that the total amount of electric charge exists Within the safe charge amount.
In the present invention, the Bipolar pulse current letter generated by pulse current generation circuit is detected by detection circuit The total amount of electric charge in the period is stimulated number at one, judges whether the total amount of electric charge detected by detection circuit surpasses using decision circuitry Safe charge amount is crossed, and when decision circuitry judges that total amount of electric charge is more than safe charge amount, compensation circuit, which generates, has net electricity The compensated pulse current signal of lotus amount so that total amount of electric charge within the safe charge amount.In this way, without using footprint area In the case of larger bulky capacitor (RC circuits), by compensated pulse current signal of the transmission with net charge amount to bidirectional pulse Electric current carries out charge balance, and charge balance ability is fully improved thereby, it is possible to interior in a limited space.
In addition, in charge compensating circuit according to the present invention, in the compensation circuit, when the decision circuitry is sentenced When the total amount of electric charge that breaks is positive value, the compensated pulse current signal of the compensation quantity of electric charge with negative value is generated so that the charge Within the safe charge amount, and when the decision circuitry judges the total amount of electric charge for negative value, generation has total amount Positive value compensation the quantity of electric charge compensated pulse current signal so that the total amount of electric charge within the safe charge amount.As a result, It can more efficiently ensure the total amount of electric charge for nerve stimulation within safe charge amount.
In addition, in charge compensating circuit according to the present invention, optionally, the amplitude of the compensated pulse current signal Less than default amplitude, and the period of the compensated pulse current signal is less than the period of the Bipolar pulse current signal. In this case, charge compensation can be rapidly completed with the mode repeatedly compensated.
In addition, in charge compensating circuit according to the present invention, optionally, in the Bipolar pulse current signal, The waveform of forward pulse current signal is with the waveform of negative-going pulse current signal on the contrary, the detection circuit detection positive arteries and veins The absolute value of the quantity of electric charge of current signal and the quantity of electric charge of the negative-going pulse current signal is rushed, the decision circuitry is by comparing The quantity of electric charge of the forward pulse current signal and the absolute value of the quantity of electric charge of the negative-going pulse current signal are described to judge Whether total amount of electric charge is more than safe charge amount.
In addition, in charge compensating circuit according to the present invention, optionally, the detection circuit detection is by pulse current The average value for the Bipolar pulse current signal that generation circuit generates, the decision circuitry judge the absolute value of the average value Whether preset value is more than, and when the absolute value of the average value is more than the preset value, compensation circuit, which generates, has net electricity The compensated pulse current signal of lotus amount so that the total amount of electric charge within the safe charge amount.In this case, pass through It detects whether average value is more than preset value, can easily determine the need for providing charge compensation.
In addition, in charge compensating circuit according to the present invention, optionally, the detection circuit detection is by the pulse The current average for the Bipolar pulse current signal that current generating circuit generates, and the current average is converted into voltage and is put down Mean value, and the decision circuitry judges whether the absolute value of the average voltage is more than preset voltage value, when the voltage When the absolute value of average value is more than the preset voltage value, the compensation circuit generates the compensated pulse electric current with net charge amount Signal so that the total amount of electric charge within the safe charge amount.In such a case, it is possible to which current average is converted into Average voltage detects, and by by the absolute value of average voltage compared with preset voltage value, when the average voltage When the absolute value of value is more than the preset voltage value, the total amount of electric charge of nerve stimulation can be used in by the compensation of compensation circuit Within the safe charge amount.
In addition, in charge compensating circuit according to the present invention, optionally, when the absolute value of the average voltage is big In preset voltage value, and when the average voltage is positive value, the compensation circuit generates the benefit of the net charge amount with negative value Pulsed current signal is repaid to be used in the total amount of electric charge of nerve stimulation within the safe charge amount, and works as the electricity The absolute value for flattening mean value is more than preset voltage value, and when the average voltage is negative value, and compensation circuit generation has The compensated pulse current signal of the net charge amount of positive value is to be used in the total amount of electric charge of nerve stimulation in the safe charge Within amount.
In addition, the second aspect of the present invention provides a kind of charge compensation method, it is for pulse current generation circuit The charge compensation method of charge compensation is carried out, the pulse current generation circuit generates the two--way pulse for nerve stimulation Stream, the charge compensation method include：Detect the Bipolar pulse current signal generated by the pulse current generation circuit One stimulation the period in total amount of electric charge；Judge to be less than or equal to safety by the total amount of electric charge that the detection circuit detects The quantity of electric charge；And it when the decision circuitry judges that the total amount of electric charge is more than safe charge amount, generates with net charge amount Compensated pulse current signal so that the total amount of electric charge within the safe charge amount.
In addition, in charge compensation method according to the present invention, optionally, when judging the total amount of electric charge for positive value When, the compensated pulse current signal of the compensation quantity of electric charge with negative value is generated so that the total amount of electric charge is in the safe charge amount Within, and when judging the total amount of electric charge for negative value, generate the compensated pulse electric current letter of the compensation quantity of electric charge with positive value Number so that the total amount of electric charge within the safe charge amount.Thereby, it is possible to more efficiently ensure for nerve stimulation Total amount of electric charge is within the safe charge amount.
In addition, the third aspect of the present invention also provides a kind of retinal prosthesis system, including：Implanted device at least has There is above-mentioned any one of them charge compensating circuit；Photographic device, is used to capture video image, and by the video figure As being converted into visual signal；And video process apparatus, it is connect with the photographic device, and the visual signal is carried out Modulated signal is handled and generates, the modulated signal is transmitted to the implanted device, the institute that the implanted device will be received It states modulated signal and is converted into the Bipolar pulse current signal as electrical stimulation signal, to the gangliocyte to retina Or Beale's ganglion cells provides the Bipolar pulse current signal to generate light sensation.
According to the present invention, pass through charge compensating circuit Active Compensation nerve fiber (such as gangliocyte or Beale's ganglion cells) On the extra net charge that there may be, the efficiency of the charge balance to stimulating charge can be improved, it is ensured that nerve stimulation Safety and reliability.In addition, can in the case where not utilizing the larger bulky capacitor of footprint area, in a limited space in fill Ground is divided to improve charge balance ability.
Description of the drawings
Fig. 1 is the structural schematic diagram for showing the retinal prosthesis system involved by embodiments of the present invention；
Fig. 2 is to show that the stimulating electrode structure of the retinal prosthesis system involved by embodiments of the present invention is implanted to Intraocular schematic diagram；
Fig. 3 is to show that stimulating electrode structure (stimulated side) shown in Fig. 2 is attached to the part on intraocular retina Schematic diagram；
Fig. 4 is the electricity for showing the pulse current generation circuit for nerve stimulation involved by embodiments of the present invention The schematic diagram of road module；
Fig. 5 is the schematic diagram for showing the Bipolar pulse current signal involved by embodiments of the present invention.
Fig. 6 is the schematic diagram for the precision for showing the different pulse current amplitudes involved by embodiments of the present invention
Fig. 7 is the schematic diagram for the circuit module for showing the charge compensating circuit involved by embodiments of the present invention；
Fig. 8 is the schematic diagram for showing the compensated pulse electric current involved by embodiments of the present invention；And
Fig. 9 is the electrical block diagram for showing the charge compensating circuit involved by embodiments of the present invention.
Specific implementation mode
Hereinafter, refer to the attached drawing, explains the preferred embodiment of the present invention in detail.In the following description, for identical Component assign identical symbol, the repetitive description thereof will be omitted.Scheme in addition, attached drawing is only schematical, the mutual ruler of component Very little shape of ratio or component etc. can be with actual difference.
(retinal prosthesis system)
Fig. 1 is the structural schematic diagram for showing the retinal prosthesis system involved by embodiments of the present invention.Fig. 2 is to show The stimulating electrode structure for having gone out the retinal prosthesis system involved by embodiments of the present invention is implanted to intraocular schematic diagram. Fig. 3 is to show that stimulating electrode structure (stimulated side) shown in Fig. 2 is attached to the partial schematic diagram on intraocular retina.
In the present embodiment, as shown in Figure 1, retinal prosthesis system includes (sometimes referred to as " artificial retina ") internal Implant part, that is, implanted device 1 and outer body, that is, external device 3.Artificial retina system involved by present embodiment In system, implanted device 1 can be coupled with external device 3 via wireless mode.In some instances, implanted device 1 with set in vitro Standby 3 can be coupled via reception antenna 11 shown in FIG. 1 with transmitting antenna 33.In addition, in the present embodiment, implantation dress Set 1 without being limited thereto with the coupled modes of external device 3, such as implanted device 1 can also be via infrared receiver with external device 3 Mode is realized.
In some instances, the main Electronic Packaging including matrix (not shown) and being arranged on matrix of implanted device 1 Body 11, stimulating electrode structure 12 and reception antenna 13.In addition, the matrix in implanted device 1 can be solid by such as suture way It is scheduled on eyeball 2.
In addition, as shown in Fig. 2, the stimulated side 12a (stimulating electrode array) of the stimulating electrode structure 12 in implanted device 1 can Entered with the notch via eyeball 2 in the vitreous chamber of eyeball 2, and be close to retina, so as to (especially to retina It is gangliocyte or the Beale's ganglion cells of retina) carry out electro photoluminescence (such as providing Bipolar pulse current) (referring to Fig. 3).
Under normal circumstances, such as the patients such as retinal pigment degeneration (RP) or age-related macular degeneration (AMD) and Speech causes the decline or death of photosensory cell because of retinal pigment degeneration (RP) or age-related macular degeneration (AMD), namely normal Pathways for vision it is hindered because of the lesion of photosensory cell disease, vision telecommunications can not be transformed by normally entering the light of intraocular Number, cause patient to blind.In the present embodiment, the stimulated side 12a of stimulating electrode structure 12 is equivalent to instead of photosensitive The effect of cell, stimulated side 12a for example provide Bipolar pulse current signal by generating electrical stimulation signal, to retina god It is stimulated (referring to Fig. 3) through ganglion cell or Beale's ganglion cells.Since most of retinal pigment degeneration (RP) or age-related macular become Other pathways for vision of property (AMD) patient other than photosensory cell obtain intact reservation mostly, therefore, gangliocyte or bipolar After cell by stimulating electrode structure 12 by electrical stimulation signal stimulation is generated, which regards via intact downstream is retained Feel that access (optic nerve) is transferred to cerebral cortex and generates light sensation, so as to partly restore the vision of patient.
Furthermore, it is necessary to explanation, although the optic nerve stimulation that present embodiment is conceived to retinal prosthesis system carries out Description, however, present embodiment is not limited to artificial retina field, on the contrary, the charge compensation electricity involved by present embodiment Road 101 is readily applicable to other nerve stimulation fields such as artificial cochlea, deep brain stimulation, pacemaker, spinal cord stimulation Device, etc..
In the present embodiment, as shown in Figure 1, external device 3 may include photographic device 31,32 and of video process apparatus Transmitting antenna 33.In vitro in equipment 3, photographic device 31 can be used for capturing video image, and the video figure that will be captured As being converted into visual signal.
In some instances, photographic device 31 can be the equipment with camera function for example video camera, digital camera, CCD camera etc..By the photographic device 31, so as to capture for example extraneous image.In addition, use for convenience, it can be with By the video camera of small volume on glasses.Alternatively, it is also possible to be used as by wearing the light glasses with camera function Photographic device 31 captures video image.Furthermore photographic device 31 can also be usedEtc. realizing.In addition, at this Can also image be obtained by using ultrasonic imaging (such as sonar) or electromagnetic wave imaging (such as radar) in embodiment, Or other can also be used to be capable of the equipment of formation range and angle information.
As shown in Figure 1, video process apparatus 32 is connect with photographic device 31, and receives and regarded by what photographic device 31 provided Feel signal.After the visual signal captured by photographic device 31 is transmitted to video process apparatus 32, video process apparatus 32 can be with The visual signal is handled.In some instances, video process apparatus 32 may include microprocessor, application-specific integrated circuit (ASIC), DSP etc., to carry out image procossing (such as sampling, coding, modulation, filtering etc.) to the visual signal.In addition, regarding Frequency processing device 32 also have power supply, the power supply can for example via the mode of wireless transmission provide energy signal to Implanted device 1, to make the implanted device being implanted in eyeball 21 be powered.
Analog signal transmitting device (i.e. transmitting antenna 33) can will be believed comprising the energy provided by video process apparatus 32 Number and treated visual signal is sent to as modulated signal (such as RF modulated signals) artificial retina implanted device 1.
On the other hand, implanted device 10 is for receiving by video process apparatus 30 via the tune that for example transmitting antenna 33 emits Signal processed, and the modulated signal is further processed, Bipolar pulse current is generated as the stimulation for nerve stimulation Electric current (stimulus signal).Specifically, reception antenna 11 shown in FIG. 1 receives the modulated signal, and it is transmitted to subsequent Electronic packing body 12 is handled.It finally, will be by electronic packing body 12 (being specifically the processing circuit in electronic packing body 12) root Electrical stimulation signal is generated according to the modulated signal and is transmitted to stimulated side 12a (such as the stimulating electrode battle arrays of stimulating electrode structure 12 Row), so as to such as retina gangliocyte or Beale's ganglion cells stimulated (referring to Fig. 3), gangliocyte or Beale's ganglion cells generates excited response to generate light sensation after receiving pulse current.In these cases, stimulated current is possible to pierce Swash the gangliocyte of retina or the Beale's ganglion cells of retina, it is also possible to while the gangliocyte of retina is arrived in stimulation Or Beale's ganglion cells.
(pulse current generation circuit)
Fig. 4 is to show that involved by embodiments of the present invention include charge compensating circuit and pulse current generation circuit Circuit module schematic diagram.
As shown in figure 4, the charge compensating circuit 101 and pulse current for nerve stimulation involved by present embodiment are produced Raw circuit 102.In the present embodiment, charge compensating circuit 101 and pulse current generation circuit 102 can be applied to Fig. 1 institutes The retinal prosthesis system shown.In this case, charge compensating circuit 101 and pulse current generation circuit 102 can be located at In implanted device 10 shown in FIG. 1 (such as in electronic packing body 12).In some instances, such as in above-mentioned artificial retina In the implanted device 10 of system, pulse current generation circuit 102 can be generated for stimulating retinal ganglial cells or bipolar The Bipolar pulse current signal of cell (referring to Fig. 5).In addition, in some instances, by the way that the thorn in implanted device 10 is arranged Swash the stimulated side 12a (with reference to figure 2) of electrode structure 12, the two--way pulse that can will be generated by pulse current generation circuit 102 Stream signal is issued to gangliocyte or the Beale's ganglion cells of such as retina.
As described above, pulse current generation circuit 102 can generate the Bipolar pulse current signal for nerve stimulation. In present embodiment, since the pulse current generation circuit 102 for nerve stimulation can be in the width for increasing boost pulse electric current The high-precision of pulse current is kept in the case of degree, therefore is capable of providing more effective electric current effect of stimulation, such as can be effective Ground stimulates the Beale's ganglion cells to retina.On the other hand, due to that can realize broader impulse modulation range, therefore, it is possible to Hardware view adapts to higher processing requirement such as stimulating algorithm optimization.
Specifically, pulse current generation circuit 102 can generate the pulse current of two kinds of different accuracies.Show at other In example, pulse current generation circuit 102 can generate the pulse current of 3 kinds, 4 kinds, 5 kinds or 5 kinds or more of different accuracy.Separately Outside, the different accuracy multiple between adjacent different pulse currents can be 2 times, for example, generating the 1st pulse electricity in current feedback circuit The feelings of the pulse current of stream, the 2nd pulse current, the 3rd pulse current, the 4th pulse current and the 5th 5 kinds of different accuracies of pulse current Under condition, the precision of the 5th pulse current is 2 times of the 4th pulse current precision, and the precision of the 4th pulse current is the 3rd pulse current 2 times of precision, the precision of the 3rd pulse current are 2 times of the precision of the 2nd pulse current, and the precision of the 2nd pulse current is the 1st arteries and veins Rush the precision of electric current 2 times.In addition, present embodiment is not limited to this, the pulse current of other different accuracies can also be used.
As shown in figure 4, pulse current generation circuit 102 is equivalent to when carrying out nerve stimulation to nerve fiber etc. is connected to resistance Anti-loading 103.For example, when the current generating circuit 100 involved by present embodiment is used for the nerve stimulation of artificial retina, The gangliocyte of retina in tissue liquid or Beale's ganglion cells can simplifiedly be equivalent to impedance load 103.
In some instances, pulse current generation circuit 102 can generate the 1st impulse amplitude precision (high-precision) and the 2nd The Bipolar pulse current of impulse amplitude precision (low precision) two kinds of different accuracies.Such as it is 1 μ that can enable the 1st impulse amplitude precision A/ walks (step), ranging from 0~8 μ A of current amplitude；It is that 8 μ A/ are walked to enable the 2nd impulse amplitude precision, ranging from the 8 of current amplitude ~512 μ A (referring to Fig. 7).Here, here, precision (the 1 μ A/ of the 1st impulse amplitude precision of the impulse amplitude of high-precision pulse electric current Step) be more than low precision pulse current impulse amplitude precision (the 2nd impulse amplitude precision is 8 μ A/ steps).In addition, other one In a little examples, pulse current generation circuit 102 is capable of providing the pulse current of more different accuracies.
(Bipolar pulse current signal)
Fig. 5 shows the schematic diagram of the Bipolar pulse current signal involved by embodiments of the present invention.Fig. 6 is to show The schematic diagram of the precision of different pulse current amplitudes involved by embodiments of the present invention
In some instances, a stimulation week of the Bipolar pulse current signal generated by pulse current generation circuit 102 Total amount of electric charge in phase T is within the safe charge amount.Specifically, in nerve stimulation field, pulse is electric in order to prevent Signal is flowed to the gangliocyte of human nerve tissue such as retina or Beale's ganglion cells generation net charge and to human nerve group It knits and damages, need to ensure that Bipolar pulse current signal stimulates the total amount of electric charge in cycle T in the safe charge at one Within amount.
Here, " safe charge amount " is nerve fiber (such as the gangliocyte of retina or Beale's ganglion cells) in safe model It can bear the maximum value of net charge in enclosing.Net charge more than the safe charge amount is possible to cause to damage to nerve fiber Wound.Therefore, it during actual nerve stimulation, needs to ensure that the total amount of electric charge for stimulating one in cycle T is controlled described Within safe charge amount.Here, a stimulation cycle T is to generate the cycle time of a stimulus signal.Total amount of electric charge refers to double The total amount of electric charge of net charge into a stimulation cycle T of pulsed current signal.In some instances, for convenience's sake, It is zero that safe charge amount, which can also be enabled,.
As described above, pulse current generation circuit 102 can generate Bipolar pulse current signal.The Bipolar pulse current is believed Number may include effective stimulus current signal and balance current signal.Wherein, effective stimulus current signal can be pierced to nerve It can be for balancing that sharp object such as gangliocyte or Beale's ganglion cells, which have the current signal of stimulation, balanced balanced current signal, The current signal of charge caused by effective stimulus current signal.In general, if effectively stimulus signal is direct impulse, Balanced balanced current signal is negative-going pulse；If effective stimulus signal is negative-going pulse, balanced balanced current signal is direct impulse.By This, it can be ensured that the total amount of electric charge of Bipolar pulse current signal (example within the safe charge amount in stimulation cycle T at one Such as zero) total amount of electric charge is.
As specific example, stimulated in cycle T at one, the negative-going pulse signal of Bipolar pulse current signal is in time Integral can be equal or close with the absolute value of integral of the direct impulse signal of Bipolar pulse current signal in time, by This, the total amount of electric charge of the Bipolar pulse current signal in cycle T (such as electricity within the safe charge amount is stimulated at one Zero) lotus total amount is.In addition, referring again to Fig. 5, as shown in figure 5, being stimulated in cycle T at one, the duration of negative-going pulse signal (negative-going pulse width) is t1, and the duration (direct impulse width) of direct impulse signal is t2, then negative-going pulse is in t1 The absolute value of integral of the absolute value of integral in length with direct impulse in t2 durations is equal or close, i.e. Bipolar pulse current The total amount of electric charge of signal within the safe charge amount (such as the total amount of electric charge is zero).
As described above, pulse current generation circuit 102 provides two different impulse amplitude precision, the 1st impulse amplitude Precision and the 2nd impulse amplitude precision, wherein the 1st impulse amplitude precision is 1 μ A/ step, and amplitude range is (such as 1 μ A, 2 0~8 μ A μA、3μA、……、8μA)；2nd impulse amplitude precision is 8 μ A/ steps, and amplitude range is 8~512 μ A (such as 8 μ A, 16 μ A, 24 μ A ..., 512 μ A) (referring to Fig. 6).In some instances, as shown in fig. 7, working as the nerve of nerve stimulation object such as retina When ganglion cell or Beale's ganglion cells need lower pulse current stimulating, it is higher that pulse current generation circuit 102 can provide precision Impulse amplitude precision (such as 1 μ A/ step), such as when the current amplitude that gangliocyte or Beale's ganglion cells need is less than or equal to When 8 μ A, the electric current that impulse amplitude precision is 1 μ A/ steps is generated, 1 μ A, 2 μ A, 3 μ A, 4 μ A, 5 μ A, 6 μ A, 7 μ A, 8 μ A can be provided The electric current of totally 8 kinds of impulse amplitudes；When the electric current that gangliocyte or Beale's ganglion cells need is more than 8 μ A, impulse amplitude essence is generated Degree for 8 μ A/ steps electric current, can provide 16 μ A, 24 μ A, 32 μ A, 40 μ A ... the electric current of 512 μ A totally 64 kinds of impulse amplitudes.Such as This, pulse current generation circuit 102 is capable of providing the impulse amplitude of at least two different precision, generates at least two different essences The pulse current of degree, thus, it is possible to provide more efficient electric current stimulation mode.
In some instances, pulse current generation circuit 102 can generate low precision pulse electricity according to pulse current parameter Stream or high-precision pulse electric current.Specifically, pulse current generation circuit 102 judges institute after receiving pulse current parameter Whether the impulse amplitude for the Bipolar pulse current signal to be generated is less than critical value.When the Bipolar pulse current signal to be generated Impulse amplitude be less than or equal to critical value when, pulse current generation circuit 102 generate high-precision pulse electric current；When being generated The impulse amplitude of Bipolar pulse current signal when being more than critical value, pulse current generation circuit 102 generates low precision pulse electricity Stream.
In the present embodiment, critical value can be set in advance.In addition, the amplitude precision of high-precision pulse electric current and The amplitude precision of low precision pulse current can also be set in advance.For example, as shown in fig. 6, critical value could be provided as 8 μ The amplitude precision of A, high-precision pulse electric current are 1 μ A/ steps, and the amplitude precision of low precision pulse current is 8 μ A/ steps.In this feelings Under condition, when pulse current generation circuit 102 judges that the amplitude for the Bipolar pulse current signal to be generated is less than or equal to 8 μ A When, pulse current generation circuit 102 generates high-precision (1 μ A/ steps) pulse current；When pulse current generation circuit 102 judges institute When the amplitude for the Bipolar pulse current signal to be generated is more than 8 μ A, pulse current generation circuit 102 generates low precision (8 μ A/ steps) Pulse current.In this way, pulse current generation circuit 102 is capable of providing the pulse current of two kinds of different accuracies, work as gangliocyte Or Beale's ganglion cells need pulse current it is smaller when, high-precision pulse current is provided, view can be more accurately stimulated The Beale's ganglion cells of film is capable of providing more efficient stimulation mode.
In some instances, when the direct impulse width of Bipolar pulse current signal is more than preset duration and direct impulse width When degree is less than critical value, or when the negative-going pulse width of Bipolar pulse current signal is more than preset duration and negative-going pulse amplitude When less than critical value, pulse current generation circuit 102 generates high-precision pulse electric current.
For the width (stimulation time) of boost pulse electric current, although the mechanism of action is not completely clear yet at present, lead to Cross extension boost pulse width (such as negative-going pulse width), more likely stimulation to deeper into nerve cell, thus, it is possible to Obtain significantly more efficient nerve stimulation.Such as retinal prosthesis system, wide boost pulse can be pierced more effectively The Beale's ganglion cells for swashing retina, thus, it is possible to provide more effective and more accurately nerve stimulation.Specifically, working as bidirectional pulse When the negative-going pulse width of current signal is more than preset duration and negative-going pulse amplitude and is less than critical value, Bipolar pulse current letter The Beale's ganglion cells that number can more accurately stimulate retina, due to one-to-one correspondence ratio of the Beale's ganglion cells on pathways for vision Gangliocyte is superior, therefore more accurately the Beale's ganglion cells of stimulation retina can form more accurate light sensation, improve Stimulate efficiency.In addition, also higher processing requirement can be adapted to such as stimulating algorithm optimization in hardware view.
In the present embodiment, when the direct impulse width of Bipolar pulse current signal is more than preset duration and direct impulse When amplitude is less than critical value, or when the negative-going pulse width of Bipolar pulse current signal is more than preset duration and negative-going pulse width When degree is less than critical value, pulse current generation circuit 102 generates high-precision pulse electric current, accurately stimulates Beale's ganglion cells, is formed More accurate light sensation can provide more efficient stimulation mode to blind person.
(charge compensating circuit)
Fig. 7 is the schematic diagram for the circuit module for showing the charge compensating circuit involved by embodiments of the present invention.Fig. 8 It is the electrical block diagram for showing the charge compensating circuit involved by embodiments of the present invention.Fig. 9 is to show this hair The schematic diagram of compensated pulse electric current involved by bright embodiment.
In the present embodiment, as shown in fig. 7, charge compensating circuit (can also claim " active charge compensating circuit ") 101 Including detection circuit 1011, decision circuitry 1012 and compensation circuit 1013.Detection circuit 1011 can be used for detecting by pulse electricity Flow the total amount of electric charge in a stimulation cycle T of the Bipolar pulse current signal that generation circuit 102 generates.In addition, decision circuitry 1012 can be used for judging whether the total amount of electric charge detected by detection circuit 1011 is more than safe charge amount.In addition, compensation circuit 1013 can be used for, when decision circuitry 1012 judges that total amount of electric charge is more than safe charge amount, generating the compensation with net charge amount Pulsed current signal is to be used in the total amount of electric charge of nerve stimulation within the safe charge amount.Here, net charge amount according to The case where needing compensation can be the quantity of electric charge of negative electrical charge, or the quantity of electric charge of positive charge.
In the present embodiment, charge compensating circuit 101 can be applied to retinal prosthesis system shown in FIG. 1.At this In the case of kind, charge compensating circuit 101 can be located in implanted device 10 shown in FIG. 1.Specifically, pulse current generates electricity Road 102 can be located at electronic packing body 12 shown in FIG. 1.In the present embodiment, charge compensating circuit 101 can be used for arteries and veins It rushes current generating circuit 102 and carries out charge compensation.
It theoretically, can be by the way that the pulse current parameter of Bipolar pulse current signal be arranged (for example, pulse current parameter can To include direct impulse width, direct impulse amplitude, negative-going pulse width, negative-going pulse amplitude, pulse spacing etc.) and make double Stimulate the total amount of electric charge in cycle T within the safe charge amount at one to pulsed current signal.However, in practical application In circuit, the Bipolar pulse current signal that pulse current generation circuit 102 is generated is because various factors stimulates cycle T at one Interior total amount of electric charge is likely to exceed safe charge amount.In this case, the net electricity that Bipolar pulse current signal is accumulated Lotus is possible to that human body ocular nerve ganglion cell or Beale's ganglion cells can be damaged.In the present embodiment, pass through charge compensation Circuit 101 carrys out the extra net charge accumulated in Active Compensation nerve fiber (such as gangliocyte or Beale's ganglion cells), can Improve the charge balance ability to stimulating charge, it is ensured that the safety and reliability of nerve stimulation.
In the present embodiment, detection circuit 1011 can be used for detecting the two-way of 102 generation of pulse current generation circuit Total amount of electric charge in one stimulation cycle T of pulsed current signal.Next, it is determined that circuit 1012 judges to be examined by detection circuit 1011 Whether the total amount of electric charge in one stimulation cycle T of the Bipolar pulse current signal of survey is more than safe charge amount.If two-way arteries and veins The total amount of electric charge in a stimulation cycle T of current signal is rushed within safe charge amount, then compensation circuit 1013 does not work；Such as Total amount of electric charge in one stimulation cycle T of fruit Bipolar pulse current signal is more than safe charge amount, then compensation circuit 1013 is produced The raw compensated pulse current signal with net charge amount so that for nerve stimulation total amount of electric charge the safe charge amount with It is interior.
Specifically, when decision circuitry 1012 judges that Bipolar pulse current signal stimulates the charge in cycle T total at one When amount is positive charge, compensation circuit 1013 generates negative current pulse, to be used in the total amount of electric charge of nerve stimulation in the peace Within the full quantity of electric charge；When decision circuitry 1012 judges that Bipolar pulse current signal stimulates at one the total amount of electric charge in cycle T to be When negative electrical charge, compensation circuit 1013 generates forward current pulse, to be used in the total amount of electric charge of nerve stimulation in the safety electricity Within lotus amount.
In the present embodiment, compensation circuit 1013 can actively carry out charge compensation.Once decision circuitry 1012 judges Total amount of electric charge in a stimulation period caused by the pulse current generation circuit 102 detected by detection circuit 1011 is more than peace The full quantity of electric charge, therefore compensation circuit 1013 can carry out charge compensation in time, improve charge balance efficiency or ability, it is ensured that pierced The safety of sharp nerve fiber.
In some instances, when the electricity in the stimulation cycle T that decision circuitry 1012 judges Bipolar pulse current signal When lotus total amount is more than safe charge amount, compensation circuit 1013 can generate the compensated pulse current signal with net charge amount, make The total amount of electric charge of nerve stimulation must be used within the safe charge amount.In addition, when decision circuitry 1012 judges bidirectional pulse When total amount of electric charge in one stimulation cycle T of current signal is less than zero, compensation circuit 1013 can be generated with the net of positive value The compensated pulse current signal of the quantity of electric charge makes the total amount of electric charge for nerve stimulation within the safe charge amount.
For example, when decision circuitry 1012 judge the total amount of electric charge that one of Bipolar pulse current signal stimulates in cycle T for- 1×10-7When the negative electrical charge of coulomb, it is 1 × 10 that compensation circuit 1013, which generates total amount of electric charge,-7The positive charge of coulomb is (for example, compensation Circuit 1013 can generate the direct impulse or compensation circuit that a pulse width is 1 millisecond, pulse amplitude is 100 microamperes 1013 can to generate a pulse width be 10 milliseconds, and pulse amplitude is 10 microamperes of direct impulse) so that it is used for nerve stimulation The total amount of electric charge within the safe charge amount.In another example when decision circuitry 1012 judges Bipolar pulse current signal One stimulation cycle T in total amount of electric charge be 1 × 10-7Coulomb positive charge when, compensation circuit 1013 generate total amount of electric charge be- 1×10-7Coulomb negative electrical charge (for example, compensation circuit 1013 can generate a pulse width be 1 millisecond, pulse amplitude 100 It is 10 milliseconds that the negative-going pulse or compensation circuit 1013 of microampere, which can generate a pulse width, and pulse amplitude is 10 microamperes Negative-going pulse) so that for nerve stimulation the total amount of electric charge within the safe charge amount.
In the present embodiment, the amplitude of compensated pulse current signal can be less than default amplitude, and compensated pulse electricity The period of Bipolar pulse current signal can be less than by flowing the period of signal.Here, default amplitude be can to nerve fiber (such as Gangliocyte or Beale's ganglion cells) minimum current magnitude that plays stimulation, by by the amplitude of compensated pulse current signal It is set below default amplitude, thus it can be prevented that compensated pulse current signal may be to nerve fiber (such as gangliocyte Or Beale's ganglion cells) generate mistake stimulation, inhibit nerve fiber (such as gangliocyte or Beale's ganglion cells) be likely to be received compensation Pulsed current signal and generate unnecessary excitement.Period alternatively, it is also possible to which compensated pulse current signal is arranged is less than two-way The period of pulsed current signal can quickly carry out charge compensation thus, it is possible to carry out charge compensation in a relatively short period of time.
In some instances, the waveform of the forward pulse current signal in Bipolar pulse current signal can be with negative-going pulse The waveform of current signal is opposite.That is, in Bipolar pulse current signal, the waveform of forward pulse current signal in addition to negative sense Outside pulsed current signal reverse phase, the waveform shape of pulse current is identical.In this way, detection circuit 1011 can detect direct impulse electricity Flow the absolute value of the quantity of electric charge of signal and the quantity of electric charge of negative-going pulse current signal.Then, decision circuitry 1012 is by comparing just Judge whether total amount of electric charge surpasses to the absolute value of the quantity of electric charge and the quantity of electric charge of negative-going pulse current signal of pulsed current signal Cross safe charge amount.
The schematic diagram of the Bipolar pulse current signal involved by embodiments of the present invention is shown referring again to Fig. 5, Fig. 5. As shown in figure 5, Bipolar pulse current signal may include direct impulse signal and negative-going pulse signal, and forward pulse current The waveform of signal is opposite with the waveform of negative-going pulse current signal.At this point, detection circuit 1011 can detect forward pulse current The absolute value of the quantity of electric charge of signal and the quantity of electric charge of negative-going pulse current signal.For example, the quantity of electric charge of forward pulse current signal Absolute value for Q1=I1 × t1, the quantity of electric charge of negative-going pulse current signal is Q2=| I2 × t2 |, | I2 × t2 | i.e. I2 × t2 Absolute value.Next, it is determined that circuit 1012 judges the difference between quantity of electric charge Q1 and quantity of electric charge Q2 i.e. net charge total amount=Q1- Q2.When quantity of electric charge Q1 is equal with quantity of electric charge Q2, it is determined that total amount of electric charge zero.When quantity of electric charge Q1 and quantity of electric charge Q2 are unequal When, it is determined that total amount of electric charge is not zero, wherein when quantity of electric charge Q1 is more than quantity of electric charge Q2, determines that total amount of electric charge is that positive value (exists Net positive charge), when quantity of electric charge Q1 is less than quantity of electric charge Q2, determine that total amount of electric charge is negative value (there are net negative charges).As long as in addition, Ensure above-mentioned total amount of electric charge whether net positive charge or net negative charge within safe charge amount.
In some instances, detection circuit 1011 can detect the bidirectional pulse generated by pulse current generation circuit 102 The average value of current signal.Specifically, by directly calculate the negative charge amount of Bipolar pulse current signal and positive charge amount it Between net charge amount, and to the net charge measure average value, generated by pulse current generation circuit 102 it is possible thereby to obtain Bipolar pulse current signal total amount of electric charge whether there is net charge.Then, decision circuitry 1012 may determine that average value Whether absolute value is more than preset value, and when the absolute value of average value is more than preset value, compensation circuit 1013 can generate tool There is the compensated pulse current signal of net charge amount to be used in the total amount of electric charge of nerve stimulation within safe charge amount.
In the present embodiment, the average value of Bipolar pulse current signal can be the average electricity of Bipolar pulse current signal Flow valuve, mean charge value etc..In addition, preset value can be pre-set current value, default charge value etc..
In some instances, the average value of Bipolar pulse current signal can be the average current of Bipolar pulse current signal Value.In this case, the average current value that detection circuit 1011 can detect Bipolar pulse current signal is Ia=| (I1 × T1+I2 × t2)/(t1+t2) |, wherein I2 is negative value.It is I ' (I ' to enable pre-set current value>0), decision circuitry 1012 may determine that IaWhether I ' is more than.If IaMore than I ', then compensation circuit 1013 generates, and there is the compensated pulse current signal of net charge amount to make Total amount of electric charge for nerve stimulation is within safe charge amount；If IaLess than or equal to I ', then the not work of compensation circuit 1013 Make.
In some instances, the average value of Bipolar pulse current signal can be the mean charge of Bipolar pulse current signal Value.In this case, the mean charge value that detection circuit 1011 can detect Bipolar pulse current signal is Qa=| (I1 × T1+I2 × t2)/2 |, wherein I2 is negative value.It is Q ' (Q ' to enable and preset charge value>0), decision circuitry 1012 may determine that QaWhether More than Q '.If QaMore than Q ', then compensated pulse current signal of the generation of compensation circuit 1013 with net charge amount is to be used in The total amount of electric charge of nerve stimulation is within safe charge amount；If QaLess than or equal to Q ', then compensation circuit 1013 does not work.
In some instances, detection circuit 1011 can detect the bidirectional pulse generated by pulse current generation circuit 102 The current average of current signal, and current average is converted into average voltage.In this case, decision circuitry 1012 It may determine that whether the absolute value of the average voltage is more than preset voltage value.In this case, exhausted when average voltage When being more than preset voltage value to value, compensation circuit 1013 can generate the compensated pulse current signal with net charge amount to use In nerve stimulation total amount of electric charge within safe charge amount.
For example, average voltage can be converted to current average by current-to-voltage converting circuit, and enable default Voltage value is the voltage value of safety, when average voltage is less than preset voltage value, shows that pulse current generation circuit 102 generates Bipolar pulse current signal (without departing from safe charge amount) is not injured to the gangliocyte of human body or Beale's ganglion cells, mend Charge compensation can need not be carried out by repaying circuit 1013；When average voltage is higher than preset voltage value, show that pulse current produces The Bipolar pulse current signal that raw circuit 102 generates may will produce injury to the gangliocyte of human body or Beale's ganglion cells, then Compensation circuit 1013 is generated the compensated pulse current signal with net charge amount and is being pacified with the total amount of electric charge for being used in nerve stimulation Within the full quantity of electric charge.
In the present embodiment, the current average of detection can be converted into decision circuitry by detection circuit 1011 1012 are easy to be judged the average voltage of (for example, decision circuitry 1012 can use voltage comparator that can be judged) Value can facilitate decision circuitry 1012 to judge whether that compensation circuit 1013 is needed to carry out charge compensation, and can improve judgement The accuracy of the judging result of circuit 1012.
In addition, in some instances, when the absolute value of average voltage is more than preset voltage value, and average voltage is just When value, compensation circuit 1013 can generate the compensated pulse current signal of the net charge amount with negative value to be used in nerve stimulation Total amount of electric charge within safe charge amount；When the absolute value of average voltage is more than preset voltage value, and average voltage is When negative value, compensation circuit 1013 generates the compensated pulse current signal of the net charge amount with positive value to be used in nerve stimulation Total amount of electric charge is within safe charge amount.
In the present embodiment, detection circuit 1011 can detect the two-way arteries and veins generated by pulse current generation circuit 102 The current average of current signal is rushed, and current average is converted into average voltage.Decision circuitry 1012 may determine that electricity Whether the absolute value for flattening mean value is more than preset voltage value, when the absolute value of average voltage is more than preset voltage value, and electricity When pressing mean value is positive value, compensation circuit 1013 generates the compensated pulse current signal of the net charge amount with negative value to be used in The total amount of electric charge of nerve stimulation is within safe charge amount；When the absolute value of average voltage is more than preset voltage value, and electricity When pressing mean value is negative value, compensation circuit 1013 generates the compensated pulse current signal of the net charge amount with positive value to be used in The total amount of electric charge of nerve stimulation is within safe charge amount.
For example, if preset voltage value is 5 millivolts (mv), (average voltage when average voltage is more than 5 millivolts When the absolute value of value is more than preset voltage value, and when average voltage is positive value), compensation circuit 1013 generates net with negative value The compensated pulse current signal of the quantity of electric charge is to be used in the total amount of electric charge of nerve stimulation within safe charge amount, for example, compensation The compensated pulse current signal that circuit 1013 generates is negative-going pulse.In addition, (the electricity when average voltage is less than -5 millivolts Flatten mean value absolute value be more than preset voltage value when, and average voltage be negative value when), compensation circuit 1013 generate have just The compensated pulse current signal of the net charge amount of value is to be used in the total amount of electric charge of nerve stimulation within safe charge amount, example Such as, the compensated pulse current signal that compensation circuit 1013 generates is direct impulse.
Fig. 8 is the electrical block diagram for showing the charge compensating circuit involved by embodiments of the present invention.Such as Fig. 8 Shown, charge compensating circuit 101 may include detection circuit 1011, decision circuitry 1012 and compensation circuit 1013.In this implementation In mode, detection circuit 1011 can specifically include the 1st resistance R1, the 2nd resistance R2 and capacitance C1.Wherein, the cathode of the 1st capacitance It is terminated into common voltage VSS with the 1st of the 1st resistance R1 the, the anode of the 1st capacitance is electrically connected the 2nd electricity with the 2nd end of the 1st resistance R1 Hinder the 2nd end of R2, the 1st end electrical connection pulse current generation circuit 102 and compensation circuit 1013 of the 2nd resistance R2.
In addition, decision circuitry 1012 can specifically include the 1st voltage comparator U1 and the 2nd voltage comparator U2.Wherein, The in-phase input end of 1 voltage comparator U1 and the in-phase input end of the 2nd voltage comparator U2 are electrically connected the 1st end of the 2nd resistance R2, The inverting input access of positive voltage VTH+, the 2nd voltage comparator U2 are preset in the inverting input access of 1st voltage comparator U1 Default negative voltage VTH-, the feeder ear of the 1st voltage comparator U1 and the feeder ear of the 2nd comparator U2 access supply voltage VDD, The ground terminal of 1st voltage comparator U1 and the ground terminal of the 2nd comparator U2 access common voltage VSS, the 1st voltage comparator U1 Output end Out1 electrical connection compensation circuit 1013 the 1st control terminal C+, the output end Out2 electrical connections of the 2nd voltage comparator U2 The feeder ear of 2nd control terminal C- of compensation circuit 1013, compensation circuit 1013 access supply voltage VDD, compensation circuit 1013 Ground terminal accesses common voltage VSS, the input terminal of the output end connection pulse current generation circuit 102 of compensation circuit 1013, arteries and veins The feeder ear access supply voltage VDD of current generating circuit 102 is rushed, the ground terminal access of pulse current generation circuit 102 is public The output end of voltage VSS, pulse current generation circuit 102 connect impedance load 103.
In addition, the Bipolar pulse current signal that detection circuit 1011 can detect the generation of pulse current generation circuit 102 exists The current average in total amount of electric charge and a stimulation cycle T in one stimulation cycle T, and one is stimulated in cycle T Current average is converted to average voltage.Decision circuitry 1012 may determine that whether above-mentioned average voltage is located at default positive electricity Between pressing VTH+ and default negative voltage VTH-, if above-mentioned average voltage is located at default positive voltage VTH+ and default negative voltage Between VTH-, then compensation circuit 1013 need not carry out charge compensation；If above-mentioned average voltage is not located at default positive voltage Between VTH+ and default negative voltage VTH-, then compensation circuit 1013 carries out charge compensation, generates the compensation arteries and veins with net charge amount Current signal is rushed, to be used in the total amount of electric charge of nerve stimulation within safe charge amount.
As specific example, it is assumed that the Bipolar pulse current signal that pulse current generation circuit 102 is generated is pierced at one The absolute value of the total amount of electric charge of (for example, the period is 1 second) is more than 5 × 10 in flyback cycle T-7Coulomb when, then compensation circuit 1013 into Row charge compensation.That is, the current average when Bipolar pulse current signal is more than 5 × 10-7Milliampere or be less than -5 × 10-7 Milliampere hour, compensation circuit 1013 carry out charge compensation.If the resistance value of the 2nd resistance R2 is 10 kilo-ohms, default positive electricity can be enabled It is 5 millivolts to press VTH+, and it is -5 millivolts to preset negative voltage VTH-.When decision circuitry 1012 judges that above-mentioned average voltage is more than 5 millis The output end Out1 of Fu Shi, the 1st voltage comparator U1 export high level, and the output end Out2 outputs of the 2nd voltage comparator U2 are high Level；When decision circuitry 1012 judges that above-mentioned average voltage is less than -5 millivolts, the output end Out1 of the 1st voltage comparator U1 Low level is exported, the output end Out2 of the 2nd voltage comparator U2 exports low level；When decision circuitry 1012 judges that above-mentioned voltage is flat When mean value is between -5 millivolts~5 millivolts, the output end Out1 of the 1st voltage comparator U1 exports low level, and the 2nd voltage compares The output end Out2 of device U2 exports high level.
In the present embodiment, the compensated pulse current signal and compensation circuit of the output end output of compensation circuit 1013 1013 the 1st control terminal C+ is related to the 2nd control terminal C- of compensation circuit 1013, please refers to the following table 1.
Table 1
1st control terminal C+ 2nd control terminal C- Compensated pulse current signal
High level High level Negative-going pulse
Low level Low level Direct impulse
Low level High level Nothing
When decision circuitry 1012 judges that above-mentioned average voltage is more than 5 millivolts, compensation circuit 1013 needs to compensate negative sense Pulse, at this point, the output end Out1 of the 1st voltage comparator U1 exports high level, the output end Out2 of the 2nd voltage comparator U2 is defeated Go out high level, i.e. the 1st control terminal C+ is high level, and the 2nd control terminal C- is high level, and as shown in table 1, compensation circuit 1013 generates Compensated pulse current signal be negative-going pulse.
In addition, when decision circuitry 1012 judges that above-mentioned average voltage is less than -5 millivolts, compensation circuit 1013 needs to mend Direct impulse is repaid, at this point, the output end Out1 of the 1st voltage comparator U1 exports low level, the output end of the 2nd voltage comparator U2 Out2 exports low level, i.e. the 1st control terminal C+ is low level, and the 2nd control terminal C- is low level, as shown in table 1, compensation circuit The 1013 compensated pulse current signals generated are direct impulse.
In addition, when decision circuitry 1012 judges that above-mentioned average voltage is between -5 millivolts~5 millivolts, compensation circuit 1013 without carrying out charge compensation, and the output end Out1 of the 1st voltage comparator U1 exports low level, the 2nd voltage comparator U2's Output end Out2 exports high level, i.e. the 1st control terminal C+ is low level, and the 2nd control terminal C- is high level, as shown in table 1, compensation Circuit 1013 is without charge compensation.
In the present embodiment, Fig. 8 is only that a kind of specific charge involved by the preferred embodiment of the present invention is mended Circuit is repaid, present embodiment is not limited to this.In charge compensating circuit 101, detection circuit 1011, decision circuitry 1012 and benefit Repay circuit 1013 specific implementation can there are many deformation.
In addition, the charge compensation method involved by present embodiment is for carrying out charge benefit to pulse current generation circuit The charge compensation method repaid, pulse current generation circuit generate the Bipolar pulse current for nerve stimulation, charge compensation method Including：Total amount of electric charge in one stimulation period of the Bipolar pulse current signal that detection is generated by pulse current generation circuit； Judge to be less than or equal to safe charge amount by the total amount of electric charge that detection circuit detects；And when decision circuitry judges that total amount of electric charge is super When crossing safe charge amount, generate with net charge amount compensated pulse current signal so that total amount of electric charge safe charge amount with It is interior.
In addition, in charge compensation method, when judging total amount of electric charge for positive value, the compensation quantity of electric charge with negative value is generated Compensated pulse current signal so that total amount of electric charge within safe charge amount, and when judging total amount of electric charge for negative value, production Life has the compensated pulse current signal of the compensation quantity of electric charge of positive value so that total amount of electric charge is within safe charge amount.As a result, can It is enough more efficiently to ensure the total amount of electric charge for nerve stimulation within safe charge amount.
In addition, in one preferred embodiment, compensation method can be restrained with charge and gradually carry out charge compensation, carried The accuracy of high charge compensation.In some instances, detection circuit 1011 can detect the generation of pulse current generation circuit 102 Bipolar pulse current signal stimulates the total amount of electric charge in cycle T at one.Decision circuitry 1012 may determine that Bipolar pulse current Signal stimulates whether the absolute value of the total amount of electric charge in cycle T is more than safe charge amount at one, when decision circuitry 1012 judges When Bipolar pulse current signal stimulates the absolute value of the total amount of electric charge in cycle T to be more than safe charge amount at one, compensation circuit 1013 carry out Partial charge compensation.For example, when decision circuitry 1012 judges that Bipolar pulse current signal is stimulated at one in cycle T Total amount of electric charge be Q1, and the absolute value of Q1>When Qs (Qs is safe charge amount), compensation circuit 1013 carries out Partial charge benefit It repays.Here Partial charge compensation can be ratio charge compensation, such as according to 30%, 40%, 50%, 60%, 70%, 80% Equal proportion value carries out charge compensation.
For example, it is assumed that safe charge amount is 5 × 10-8Coulomb, when decision circuitry 1012 judges that Bipolar pulse current signal exists Total amount of electric charge in one stimulation cycle T is 1 × 10-7Coulomb negative electrical charge when, compensation circuit 1013 can according to 50% ratio Example carries out positive charge compensation, i.e. compensation circuit 1013 can carry out 5 × 10-8The positive charge compensation of coulomb.It is then detected that circuit 1011 can continue to detect the accumulative total amount of electric charge generated of pulse current generation circuit 102, if decision circuitry 1012 judges pulse The accumulative total amount of electric charge generated of current generating circuit 102 is 6 × 10-8The negative electrical charge of coulomb, compensation circuit 1013 carry out 3 × 10-8 The positive charge compensation of coulomb.Later, it is total to continue the 102 accumulative charge generated of detection pulse current generation circuit for detection circuit 1011 Amount, when decision circuitry 1012 judge the accumulative total amount of electric charge generated of pulse current generation circuit 102 more than safe charge amount (5 × 10-8) when, compensation circuit 1013 continues to carry out charge compensation according to 50% ratio, until when decision circuitry 1012 judges pulse When within safe charge amount, compensation circuit 1013 stops the absolute value of the accumulative total amount of electric charge generated of current generating circuit 102 Carry out charge compensation.Certainly, after compensation circuit 1013 stops carrying out charge compensation, detection circuit 1011 can continue to detect The accumulative total amount of electric charge generated of pulse current generation circuit 102, in other words, detection circuit 1011 can be constantly in work State is detected in real time, once detecting the quantity of electric charge, exceeded (the accumulative charge generated of pulse current generation circuit 102 is total The absolute value of amount is more than safe charge amount), compensation circuit 1013 can carry out charge compensation.
In another example, it is assumed that safe charge amount is 5 × 10-8Coulomb, when decision circuitry 1012 judges Bipolar pulse current signal It is 1 × 10 that the total amount of electric charge in cycle T is stimulated at one-7When the negative electrical charge of coulomb, positive electricity can be carried out according to 60% ratio Lotus is supplemented, i.e., compensation circuit 1013 carries out 6 × 10-8The positive charge compensation of coulomb (it should be noted that in real process, compensates The charge that circuit 1013 compensates is not necessarily equal to 6 × 10-8The positive charge of coulomb), as shown in figure 5, then detection circuit 1011 Continue to detect the accumulative total amount of electric charge generated of pulse current generation circuit 102, if decision circuitry 1012 judges that pulse current generates The accumulative total amount of electric charge generated of circuit 102 is 6 × 10-8The negative electrical charge of coulomb, compensation circuit 1013 carry out 3.6 × 10-8Coulomb Positive charge compensates.Later, it is total can to continue the 102 accumulative charge generated of detection pulse current generation circuit for detection circuit 1011 Amount.When decision circuitry 1012 judge the accumulative total amount of electric charge generated of pulse current generation circuit 102 be more than safe charge amount (5 × 10-8) when, compensation circuit 1013 continues to carry out charge compensation according to 60% ratio, until when decision circuitry 1012 judges pulse When the absolute value of the accumulative total amount of electric charge generated of current generating circuit 102 is less than safe charge amount, compensation circuit 1013 stop into Row charge compensation.Certainly, after compensation circuit 1013 stops carrying out charge compensation, detection circuit 1011 can continue to detect arteries and veins The accumulative total amount of electric charge generated of current generating circuit 102 is rushed, in other words, detection circuit 1011 can be constantly in work shape State is detected in real time, once detect exceeded (the accumulative total amount of electric charge generated of pulse current generation circuit 102 of the quantity of electric charge Absolute value be more than safe charge amount), compensation circuit 1013 can carry out charge compensation.
In some instances, detection circuit 1011 can detect the two--way pulse of the generation of pulse current generation circuit 102 Stream signal stimulates the total amount of electric charge in cycle T at one.Decision circuitry 1012 may determine that Bipolar pulse current signal at one Stimulate whether the total amount of electric charge in cycle T is more than safe charge amount.When decision circuitry 1012 judges that Bipolar pulse current signal exists When total amount of electric charge in one stimulation cycle T is more than safe charge amount, compensation circuit 1013 can carry out Partial charge compensation.Example Such as, when decision circuitry 1012 judges that Bipolar pulse current signal stimulates the total amount of electric charge in cycle T for Q1 at one, and Q1 is more than When safe charge amount, compensation circuit 1013 can carry out Partial charge compensation, and Partial charge compensation here can be ratio electricity Lotus compensates, such as carries out charge compensation according to 30%, 40%, 50%, 60%, 70%, 80% equal proportion value.
For example, when decision circuitry 1012 judges that Bipolar pulse current signal stimulates the total amount of electric charge in cycle T for 1 at one ×10-7When the negative electrical charge of coulomb, positive charge supplement can be carried out according to 50% ratio, i.e. compensation circuit 1013 carries out 5 × 10-8The positive charge compensation of coulomb.It is then detected that circuit 1011 can continue to detect the accumulative generation of pulse current generation circuit 102 Total amount of electric charge.If it is determined that circuit 1012 judges the accumulative total amount of electric charge generated of pulse current generation circuit 102 for 6 × 10-8Library The negative electrical charge of human relations, then compensation circuit 1013 can continue 3 × 10-8 coulombs positive charge compensation.Later, detection circuit 1011 can continue to detect the accumulative total amount of electric charge generated of pulse current generation circuit 102.When decision circuitry 1012 judges pulse When the accumulative total amount of electric charge generated of current generating circuit 102 is more than safe charge amount, compensation circuit 1013 can continue according to 50% ratio carries out charge compensation, until when decision circuitry 1012 judges the accumulative electricity generated of pulse current generation circuit 102 When within safe charge amount, compensation circuit 1013 can stop carrying out charge benefit to pulse current generation circuit 102 lotus total amount It repays.Certainly, after compensation circuit 1013 stops carrying out charge compensation, detection circuit 1011 can continue to detect pulse current production The raw accumulative total amount of electric charge generated of circuit 102.In other words, detection circuit 1011 can be constantly in working condition, in real time Ground is detected, once detecting that the quantity of electric charge is more than safe charge amount, compensation circuit 1013 can carry out charge compensation.
In another example when decision circuitry 1012 judges that Bipolar pulse current signal stimulates at one the total amount of electric charge in cycle T It is 1 × 10-7Coulomb negative electrical charge when, can according to 60% ratio carry out positive charge supplement, i.e., compensation circuit 1013 carry out 6 × 10-8The positive charge compensation of coulomb.It is then detected that circuit 1011 can continue to detect the accumulative generation of pulse current generation circuit 102 Total amount of electric charge.If it is determined that circuit 1012 judges the accumulative total amount of electric charge generated of pulse current generation circuit 102 for 6 × 10-8 Coulomb negative electrical charge, then compensation circuit 1013 continue 3.6 × 10-8 coulomb positive charge compensate.Later, detection circuit 1011 can continue to detect the accumulative total amount of electric charge generated of pulse current generation circuit 102, when decision circuitry 1012 judges pulse When the accumulative total amount of electric charge generated of current generating circuit 102 is more than safe charge amount, compensation circuit 1013 can continue according to 60% ratio carries out charge compensation, until when decision circuitry 1012 judges the accumulative electricity generated of pulse current generation circuit 102 When lotus total amount is equal to zero, compensation circuit 1013 can stop carrying out charge compensation.Certainly, stop carrying out electricity in compensation circuit 1013 After lotus compensation, detection circuit 1011 can continue to detect the accumulative total amount of electric charge generated of pulse current generation circuit 102.Namely It is to say, detection circuit 1011 can be constantly in working condition, be detected in real time, once detect that the quantity of electric charge is more than peace The full quantity of electric charge, compensation circuit 1013 can carry out charge compensation.
Although being illustrated to the present invention above in association with drawings and examples, it will be appreciated that above description The invention is not limited in any way.Those skilled in the art without departing from the true spirit and scope of the present invention may be used To deform and change to the present invention as needed, these deformations and variation are within the scope of the present invention.

Claims (10)

1. a kind of charge compensating circuit of nerve stimulation, which is characterized in that
It is the charge compensating circuit for carrying out charge compensation to pulse current generation circuit, the pulse current generation circuit production The raw Bipolar pulse current signal for nerve stimulation,
The charge compensating circuit includes：
Detection circuit is used to detect one of the Bipolar pulse current signal generated by the pulse current generation circuit Stimulate the total amount of electric charge in the period；
Decision circuitry is used to judge whether the total amount of electric charge detected by the detection circuit to be more than safe charge amount；With And
Compensation circuit is used for when the decision circuitry judges that the total amount of electric charge is more than safe charge amount, and generating has only The compensated pulse current signal of the quantity of electric charge so that the total amount of electric charge within the safe charge amount.
2. charge compensating circuit according to claim 1, which is characterized in that
In the pulse current generation circuit, two different impulse amplitude precision are provided,
In the compensation circuit, when the decision circuitry judges the total amount of electric charge for positive value, the benefit with negative value is generated The compensated pulse current signal of the quantity of electric charge is repaid so that the total amount of electric charge is within the safe charge amount, and
When the decision circuitry judges the total amount of electric charge for negative value, the compensated pulse of the compensation quantity of electric charge with positive value is generated Current signal so that the total amount of electric charge within the safe charge amount.
3. charge compensating circuit according to claim 1 or 2, which is characterized in that
The amplitude of the compensated pulse current signal is less than default amplitude, and the period of the compensated pulse current signal is less than The period of the Bipolar pulse current signal.
4. charge compensating circuit according to claim 1, which is characterized in that
In the Bipolar pulse current signal, the waveform of forward pulse current signal and the waveform phase of negative-going pulse current signal Instead,
The detection circuit detects the charge of the quantity of electric charge and the negative-going pulse current signal of the forward pulse current signal The absolute value of amount, the quantity of electric charge and the negative-going pulse electric current of the decision circuitry by comparing the forward pulse current signal The absolute value of the quantity of electric charge of signal come judge the total amount of electric charge whether be more than safe charge amount.
5. charge compensating circuit according to claim 1, which is characterized in that
The average value for the Bipolar pulse current signal that the detection circuit detection is generated by the pulse current generation circuit,
The decision circuitry judges whether the absolute value of the average value is more than preset value, and when the absolute value of the average value When more than the preset value, the compensation circuit generates the compensated pulse current signal with net charge amount so that the charge is total Amount is within the safe charge amount.
6. charge compensating circuit according to claim 1, which is characterized in that
The current average for the Bipolar pulse current signal that the detection circuit detection is generated by the pulse current generation circuit, And the current average is converted into average voltage, and
The decision circuitry judges whether the absolute value of the average voltage is more than preset voltage value, when the average voltage Absolute value when being more than the preset voltage value, the compensation circuit generate the compensated pulse current signal with net charge amount with Make the total amount of electric charge within the safe charge amount.
7. charge compensating circuit according to claim 6, which is characterized in that
When the absolute value of the average voltage is more than preset voltage value, and the average voltage is positive value, the compensation The compensated pulse current signal that circuit generates the net charge amount with negative value is existed with the total amount of electric charge for being used in nerve stimulation Within the safe charge amount, and
When the absolute value of the average voltage is more than preset voltage value, and the average voltage is negative value, the compensation The compensated pulse current signal that circuit generates the net charge amount with positive value is existed with the total amount of electric charge for being used in nerve stimulation Within the safe charge amount.
8. a kind of charge compensation method, which is characterized in that
It is the charge compensation method for carrying out charge compensation to pulse current generation circuit, the pulse current generation circuit production The raw Bipolar pulse current signal for nerve stimulation,
The charge compensation method includes：
Electricity in one stimulation period of the Bipolar pulse current signal that detection is generated by the pulse current generation circuit Lotus total amount；
Judge whether the total amount of electric charge is more than safe charge amount；And
When the total amount of electric charge be more than the safe charge amount when, generate with net charge amount compensated pulse current signal so that The total amount of electric charge is within the safe charge amount.
9. charge compensation method according to claim 8, which is characterized in that
In the pulse current generation circuit, two different impulse amplitude precision are provided,
When judging the total amount of electric charge for positive value, generate with negative value compensation the quantity of electric charge compensated pulse current signal so that The total amount of electric charge within the safe charge amount, and
When judging the total amount of electric charge for negative value, generate with positive value compensation the quantity of electric charge compensated pulse current signal so that The total amount of electric charge is within the safe charge amount.
10. a kind of retinal prosthesis system, which is characterized in that
Including：
Implanted device, at least with the charge compensating circuit described in any one of claim 1 to 7；
Photographic device is used to capture video image, and the video image is converted into visual signal；And
Video process apparatus is connect with the photographic device, and the visual signal is handled and generates modulation letter Number, the modulated signal is transmitted to the implanted device,
The modulated signal received is converted into the Bipolar pulse current as electrical stimulation signal by the implanted device Signal, to generate light sensation to the retina granting Bipolar pulse current signal.
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