CN104815179B - A kind of Chinese medicine composition for treating neurasthenia sleep-disorder and preparation method thereof - Google Patents
A kind of Chinese medicine composition for treating neurasthenia sleep-disorder and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese medicine composition for treating neurasthenia sleep-disorder and preparation method thereof, belong to the field of Chinese medicines.Said composition, it is made up of each bulk drug of following parts by weight：20 40 parts of dogwood fruit, 5 15 parts of Semen Ziziphi Spinosae (parched), 5 15 parts of raw and fried, 36 parts of the coptis, 0.4 4 parts of Chinese cassia tree, 7 12 parts of donkey-hide gelatin, 15 25 parts of Ligusticum wallichii, 15 25 parts of raw oyster, 10 15 parts of Poria cocos, 10 15 parts of the wind-weed, 15 25 parts of gypsum, 10 15 parts of conic gymnadenia tuber, 10 15 parts of Rhodobryum giganteum.Effect of the present invention is filled blood liver and kidney benefiting, mental-tranquilization, safe to use, few side effects evident in efficacy to sleep-disorder caused by neurasthenia, and more simple western medical treatment has a clear superiority, and clinic is promoted.
Description
Technical field
The invention belongs to technical field of traditional Chinese medicines, more particularly to a kind of Chinese traditional medicine composition for treating neurasthenia sleep-disorder
Thing and preparation method thereof.
Background technology
The neurasthenia aypnia category traditional Chinese medical science " is insomnia " category, is mainly in the young and the middle aged, in the majority with brain worker, onset is delayed
Slowly, the course of disease is longer.Excitement at night is mainly shown as, vexed difficult dormancy, dreaming often and waking easily, daytime is drowsy, lassitude, lassitude hypodynamia,
Companion feels dizzy, palpitation and amnesia, the symptom such as apocleisis abdominal distension.
Insomnia almost with have a sleepless night for unique symptom, other symptoms are seldom, and neurasthenia except have main suit have a sleepless night in addition to, easily
Weak, easy excited, Somatic discomfort symptom is significantly more than insomnia.Although currently used for treating the medicine of neurasthenia aypnia very
It is more, but all can not thoroughly effect a radical cure.Western medicine is more based on hypnotic, but these medicine side effects are big, and most dependence is stronger, easily into
Addiction, and can not effect a radical cure.
The content of the invention
The invention provides a kind of positive effect, efficient high, the treatment neurasthenia sleep-disorder having no side effect
Chinese medicine composition and preparation method thereof.
The present invention is achieved by the following technical solutions：
A kind of Chinese medicine composition for treating neurasthenia aypnia, it is characterised in that by each bulk drug group of following parts by weight
Into：Dogwood fruit 20-40 parts, Semen Ziziphi Spinosae (parched) 5-15 parts, raw and fried 5-15 parts, coptis 3-6 parts, Chinese cassia tree 0.4-4 parts, donkey-hide gelatin 7-12
Part, Ligusticum wallichii 15-25 parts, raw oyster 15-25 parts, Poria cocos 10-15 parts, wind-weed 10-15 parts, gypsum 15-25 parts, conic gymnadenia tuber 10-15
Part, Rhodobryum giganteum 10-15 parts.
Preferably, the parts by weight of each bulk drug are：30 parts of dogwood fruit, 10 parts of Semen Ziziphi Spinosae (parched), 10 parts of raw and fried, the coptis 8
Part, 3 parts of Chinese cassia tree, 10 parts of donkey-hide gelatin, 20 parts of Ligusticum wallichii, 20 parts of raw oyster, 12 parts of Poria cocos, 12 parts of the wind-weed, 20 parts of gypsum, conic gymnadenia tuber 12
Part, 12 parts of Rhodobryum giganteum.
Medicine activity component of the present invention can add various auxiliary materials required when preparing different dosage forms, such as disintegrant, profit
Lubrication prescription, binder etc., any suitable clinical preparation is prepared into the method for Chinese medicinal of routine, such as can be glue
Wafer, pill, powder, granule, tablet, oral liquid or pill etc., preferably capsule or granule.
A kind of preparation method of Chinese medicine composition of the present invention：Each bulk drug is weighed by the parts by weight；By each raw material medicinal powder
It is broken, sieving, the auxiliary material or excipients needed for preparations shaping are added, is prepared into capsule, tablet or pill.
Preferably, the method for described Chinese goldthread colla corii asini composition, it is characterised in that comprise the following steps：
(1) each bulk drug is weighed by the parts by weight；
(2) dogwood fruit, raw oyster, Poria cocos, the wind-weed, gypsum, Rhodobryum giganteum are extracted twice with water, merges aqueous, decompression is dense
Contracting, concentrate is spray-dried, standby；
(3) coptis, conic gymnadenia tuber, Chinese cassia tree, Ligusticum wallichii, Semen Ziziphi Spinosae (parched) and raw and fried are extracted twice with 40-80% ethanol, will
After ethanol extract recovery ethanol, spray drying is standby；
(4) it is well mixed after donkey-hide gelatin is crushed with the product obtained by step (2) and (3), adds pharmaceutical preparation auxiliary material and mix
It is even that intermediate formulations are made, then finished dosage form is made through preparations shaping technique.
Present invention also offers application of the described composition in neurasthenia sleep disorder remedies are prepared.
Neurasthenia aypnia is hindered by feelings will more, and spirit is overstretched, or after serious disease prolonged illness, visceral dysfunction
It is caused.If angry depression, liver depression forming fire, the heart-yin of burning is disturbed and gods, can cause conscience excess heat；Over-anxiety, consume sad spleen, spleen
Empty blood is few, and the heart, which loses, to be moistened foster, and the mind is not kept, and is that heart spleen two loses, and fleshliness does not save, kidney yin loss, flaring up of deficient fire, and kidney water can not go up tide
Internal heat can not descend Ji and can all cause neurasthenia aypnia.Theory of traditional Chinese medical science thinks, a disease of having a sleepless night, regardless of the cause of disease, the interpretation of the cause, onset and process of an illness
Always lose and hand over for yin-Yang, sun does not enter caused by the moon.Neurasthenia aypnia, due to the long-term nighttime sleep deficiency of patient, dark consumption essence
Blood, prevent negative and positive from interdependent and mutually promoting, it is yin-yang deficiency, show as：The night deficiency of Yin, outward dispersion of deficient YANG, sun do not enter the moon, and vexed hardly possible is slept, or
Dreaming often and waking easily, therefore《Doctor's effect, which must not secretly hand down, sleeps》Have " night, cloudy arrogant, mesh closed and reposal based on the moon, if the deficiency of Yin is won by sun,
All the night bother and egersis " say.Daytime, deficiency of yang the moon was held back, and sun does not go out the moon；Or spleen sun deficiency, lucid yang failing to raise；Or deficiency of heart-YANG,
Blood fortune is powerless, symptoms include spiritlessness and weakness, lassitude, palpitation and amnesia, feels dizzy.
Fang Xie：Dogwood fruit, donkey-hide gelatin, conic gymnadenia tuber benefiting qi and nourishing blood, enriching yin liver and kidney benefiting are monarch drug in a prescription altogether in side；The wind-weed, gypsum relieve inflammation or internal heat
Relieving restlessness, drop are mutually fiery, the coptis, Chinese cassia tree restoring normal coordination between heart and kidney；Oyster eliminating the phlegm checking exuberance of yang, raw ripe spina date seed, Rhodobryum giganteum hold back gas calm the nerves, kidney of feeling at ease,
Ligusticum wallichii blood-activating and qi-promoting, carry medicine and enter brain.All medicines share, the liver and kidney benefiting that fills blood, the work(of mental-tranquilization is played altogether, to caused by neurasthenia
Sleep-disorder has good effect.
The research of each medicine in prescription of the present invention：
Dogwood fruit:Sour, puckery, slightly warm in nature.Function:Tonify the liver and kidney, puckery smart hidroschesis：For kidney deficiency and liver the soreness of waist seminal emission,
Have a dizzy spell, the disease such as menorrhalgia and frequent micturition, spontaneous perspiration.Cure mainly：Control soreness of waist and knee joint, dizziness, tinnitus, impotence, seminal emission, urine frequency
Number, liver cold of insufficiency type heat, incessant sweating due to debility, the heart shake arteries and veins and dissipated.《This warp》：Perverse trend fever and chills under the main heart, middle benefit gas, by cold-dampness numbness, go three worms.《Thunder
Public big gun processs opinion》：Strong vigour, secret essence.《Do not record》：Stomach ailment said due to cold or exposure, fever and chills hernia lump in the abdomen, intermittent headache, general mood go to come, and nasal obstruction, mesh is yellow, deaf,
Pimples, middle benefit gas, lower gas, perspire, Qiang Yin, strengthening the essence, five viscera settling, lead to nine orifices, only small facility, improving eyesight, strength.《Haigoushen》：Control brain
Ostalgia, only the moon, water was indefinite, kidney tonifying gas；Xing Yangdao, adds marrow, treats tinnitus, except sore on face, it is main can sweating, only old man's urine do not save.
《Japan hanako materia medica》：Warm waist and knee, helps water dirty, except a wind cutting, cuts gas one by one, breaks Disorder knots, controls wine Zha.《Pearl sac》：Warm liver.《This
Grass asks former》：Only chronic diarrhea, heating sweating of having a guilty conscience.
Ligusticum wallichii：Acrid flavour, it is warm-natured.Return liver, courage, pericardium channel.Major function：Blood-activating and qi-promoting, wind-expelling pain-stopping.For menstruation not
Adjust, closed dysmenorrhea, abdominal mass stomachache, chest side of body shouting pain, tumbling and swelling, headache, arthralgia pain due to rheumatism.《This warp》：Main apoplexy enters brain headache, trembles with fear
Numbness, muscle contraction emergency, gold wound, married woman's blood close s.m.p.《Do not record》：Moved except cold in brain, urticaria goes to come on face, mesh lacrimation, profuse nasal discharge and spittle, neglects
Suddenly such as liquor-saturated, all cold gas, trusted subordinate is hard bitterly, middle evil, and the anxious swelling and pain of soldier, side of body wind bitterly, is trembled with fear in middle benefit gas.《Japan hanako materia medica》：A wind cutting is controlled,
All gas, all strains, all blood, mend the exhaustion or lesion of the five internal organs, strengthen the bone, and adjust many arteries and veins , Po Disorder knots place blood, support new blood, put on flesh, profuse nasal bleeding, spit blood
And excessive blood, hemorrhoid complicated by anal fistula, brain carbuncle carbuncle on the back, scrofula goitre are gone to live in the household of one's in-laws on getting married, sore scabies, and apocenosis dispersing blood stasis blood.《Medicine origin》：Enrich blood, control headache due to deficiency of blood.King
Good Gu：Irritability is searched, tonifying liver blood, profit liver is dry, and it is empty to mend wind.《Detailed outline》：Eliminating dampness, antidiarrheal dysentery, promote breath and open depression.
Oyster：Taste is salty, cold nature.Return liver, courage, kidney channel.Major function：It is transquilization with heavy material, checking exuberance of yang tonifying yin, softening and resolving hard mass.With
In insomnia of palpitating with fear, dizziness and tinnitus, scrofula subcutaneous nodule, abdominal mass lump in the abdomen.Calcined oyster shell convergence is astringent or styptic treatment for spontaneous sweating.For spontaneous sweating, band, stomach are collapsed in seminal emission
Pain acid regurgitation.《This warp》：Main typhoid fever fever and chills, a kind of malaria is voluminous, frightened gas of being enraged, and except slow mouse fistula is arrested, woman is red white with.The strong bone of long term usage
Section.《Do not record》：Except heat is stayed in joint Rong Wei, abnormal heat goes to carry out indefinite, dysphoria；Hidroschesis, it is pained depressed, quench the thirst, except old blood.Puckery size
Essence, larynx numbness, cough, the lower ruffian heat of the heart side of body are let out in intestines, only stool and urine, treatment.《Haigoushen》：" cure mainly woman's metrorrhagia.Only night sweat, except wind-heat,
Analgesic.Control a kind of malaria.Again and bark of eucommia clothes stop night sweat.How hot patient is empty and, adds with glutinous rehmannia, small grass.《Haiyao Bencao, Oversea Materia Medica》：Main man loses
Essence, the weary damage of consumptive disease, kidney tonifying healthy tendency, only night sweat, goes dysphoria with smothery sensation, and cure the wound fever and chills phlegm, can take a tonic or nourishing food to build up one's health and calm the nerves, control child's frightened epilepsy.《Pearl
Capsule》：" soft mass in the abdomen.Control again under band, a kind of malaria, sore swells, be the agent of softening hard masses inducing astrigency.《Detailed outline》：Resolving phlegm and softening hard masses, removing damp-heat, only heart spleen
Bitterly, under dysentery, reddish and whitish turbid urine, the hernia that disappears lump in the abdomen accumulates block, goitre disease tuberculosis to gas.
Poria cocos：It is sweet, light, it is mild-natured.The thoughts of returning home, lung, spleen, kidney channel.Major function：Clearing damp and promoting diuresis, invigorating the spleen calming heart.For oedema
Oliguria, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.《Do not record》:Only quench one's thirst, like to sleep, big abdomen, leaching
Drip, phlegm water in diaphragm, oedema leaching knot.Chest internal organs is opened, adjusts visceral-qi, cuts down kidney heresy, long cloudy, benefiting energy, during guarantor god keeps.《Haigoushen》:Appetizing,
Preventing or arresting vomiting is inverse, is apt to tranquilizing mind.Main consumptive lung disease phlegm is stopped up.Control pediatric epilepsy scared, trusted subordinate's turgor, married woman's heat gonorrhea.《Japan hanako materia medica》:Mend the exhaustion or lesion of the five internal organs seven
Wound, it is antiabortive, waist and knee is warmed up, happy intelligence development is only forgetful.《Modality》:Cure mainly and throb with fear that Ji Rou Shun muscle is cautious, and a dizzy agitation is controlled on side.
The coptis：Bitter, it is cold in nature.The thoughts of returning home, spleen, stomach, liver, courage, large intestine channel.Major function：Heat-clearing and damp-drying drug, purging intense heat and detonicating.With
In damp and hot feeling of fullness, acid regurgitation is vomitted, rush down dysentery, jaundice, unconsciousness due to high fever, heart-fire hyperactivity, dysphoria and insomnia, blood-head tells nosebleed, hot eyes, is had a toothache,
Quench one's thirst, carbuncle swells furunculosis；Eczema, wet sore are controlled outside, duct is suppurated.《This warp》：Main hot gas mesh pain, corner of the eyes wound weep, and improving eyesight, intestines debate stomachache
Diarrhea, swell and ache in married woman's the moon.《Essentials of Materia Medica》：Control ulcer sore scabies, wine poison, the skin infections of newborn infants.Except infantile malnutrition due to digestive disturbances or intestinalparasites, ascarid is killed.
Donkey-hide gelatin：It is sweet, it is mild-natured.Return lung, liver and kidney channel.Major function：Enrich blood enriching yin, moisturize, stop blooding.For blood deficiency chlorosis,
Dizziness palpitaition, impotence weakness, dysphoria and insomnia, endogenous deficient wind, xeropulmonary cough, overstrain cough spitting of blood, haematemesis hematuria, uterine bleeding of having blood in stool, gestation
Threatened abortion.《This warp》：Collapsed in main trusted subordinate, the extremely voluminous symptoms like malaria of labor, waist stomachache, painful limbs, blood under woman.It is antiabortive.Long term usage QI invigorating.
《Haigoushen》：Main hard muscles and bones, QI invigorating stop dysentery.《A thousand pieces of gold food therapy》：Control strong wind.《Japan hanako materia medica》：Control a wind cutting, and profuse nasal bleeding,
Under haematemesis, intestines wind, bloody flux and metrorrhagia band.《Detailed outline is picked up any lost article from the road》：Lumbago caused by internal damage is controlled, strongly stretches muscle, adds essence and reinforces the kidney.
Spina date seed：It is mild-natured, it is sweet, sour.Return liver, courage, the heart channel of Hang-Shaoyin.Major function：Tonifying liver, calming heart, arrest sweating, promote the production of body fluid.For void
Tired egersis, horrified to much dream, body void hidrosis, injury thirst.《This warp》：Main trusted subordinate's fever and chills, heresy knot gas gather, painful limbs, arthritis with fixed pain caused by dampness.
《Do not record》：Master is vexatious to sleep, and pain, blood turn to let out long, abnormal sweating polydipsia, bowl spares, beneficial irritability, hard muscles and bones, helps cloudy gas, make us navel up and down
Fertilizer is strong.《Haigoushen》：Cage bar bone wind, fry end and take it as soup.Wang Haogu：Milk-livered egersis is controlled, is trembled with fear, fries clothes；Somnolence due to gallbladder-excess is controlled, heat
, it is raw to use.《Collected statements on the herbal foundation》：Hold back gas to calm the nerves, flourish muscle supports marrow, and stomach fortune spleen.《Book on Chinese herbal medicine is new again》：Soothing the liver qi-regulating, moistens the lung and nourish yin, temperature
Middle dampness removing, gas hidroschesis is held back, beneficial will is breathed out surely, hearing-improing and eyesight improving.
Rhodobryum giganteum, moss Bryaceae rhodobryum spp plant warm ground great Ye moss Rhodobryumgiganteum
（Schwaegr.）Par., alias rose rhodobryum herb, fennel firewood grass, iron pin yunna spiraea, gigantism rhodobryum herb, great Ye moss；It is acrid flavour, hardship, mild-natured.Function
With curing mainly：Mental-tranquilization, clear liver and improve vision.For palpitation and severe palpitation, neurasthenia, red eye, swell pain is controlled in external application.《Yunnan Chinese herbal medicine choosing》:
Calmness, establishing-Yang.《Simao, Yunnan Chinese herbal medicine selects》：Calm the nerves calmness.Control nervous, palpitaition, heart disease.
The wind-weed：It is bitter, sweet, it is cold in nature.Return lung, stomach, kidney channel.Major function：Clearing heat-fire, fluid dryness.For outer sensible heat
Disease, hyperpyrexia polydipsia, lung-heat type cough, osteopyrexia and fever, Heat Diabetes, dry constipation of intestines.《This warp》：Main quench one's thirst is hankered, remove pathogenic factor limbs
Edema, lower water, tonifying for the deficiency, QI invigorating.《Do not record》：Cure the wound cold chronic malaria dysphoria with smothery sensation, coerce lower perverse trend, disliked in diaphragm and wind sweat in subcutaneous ulcer.Tao Hongjing：
Thermojunction is very treated, also main malaria heat is tired.《Haigoushen》：Cure mainly vexed hot-tempered vexed, the hot labor contact of bone, raw general debility during puerperium, kidney qi labor, loathing of cold void
Damage, suffer from that people is empty and dry, add and use it.《Japan hanako materia medica》：Logical small intestine, dissolving phlegm are only coughed, and embellish lung, qi-restoratives is weary, feels at ease only to shy
Throb with fear.Zhang Yuansu：" the cool heart reduces phlegm and internal heat, and controls positive naked light heat, rushes down bladder kidney channel fire, pyretic headache, diarrhea pain in the back, is smelt as of rotten fish in larynx.Wang Hao
It is ancient：Purte the white, kidney nourishing water, control gate of vitality's phase fire and have a surplus.《Book on Chinese herbal medicine asks former》：Blood of coughing is controlled, is breathed heavily, leaching, stomatosis, hematuria, hiccup, night sweat,
Seminal emission, numbness impotence , Chi Zong.
Gypsum：It is sweet, pungent, property Great Cold.Attach to the lung and stomach meridians.Major function：Clearing heat-fire, relieving restlessness are quenched the thirst.For outer sensible heat
Disease, hyperpyrexia polydipsia, dyspnea and cough due to lung-heat, the high Sheng of stomach fire, have a headache, toothache.《This warp》：Main apoplexy fever and chills, heart subinverse gas, shy asthma, dry
Tongue is burnt, it is impossible to ceases, hardness and fullness in the abdomen pain, galactopoiesis, metal-inflicted wound.《Do not record》：Except when gas headache body heat, three burnt big heat, skin heat, stomach middle diaphragm
Heat, expelling pathogenic factors from muscles by diaphoresis, only quench one's thirst tired inverse, abdominal distension is panted breath cruelly, pharynx heat.Also bath soup can be made.《Haigoushen》：Cold headache is controlled such as to split,
High fever, skin such as fiery dry, polydipsia, expelling pathogenic factors from muscles and skin, goes out malicious sweat, is tied in main logical stomach, unhappy, epigastric oppression is irritated, controls dry Jiao of lip.《Solar corona
Book on Chinese herbal medicine》：It is fanatical to control day row, lower breast, intermittent headache rotation is vexed hot-tempered, wipes tooth benefit tooth.《Changsha medicine solution》：Clear away heart-fire lung, controls agitation, let out it is hot and suffocating,
It is only dry thirsty, control fanatical, fire is coughed, and receives hot sweat, and disappear hot phlegm, firmly nosebleed epistaxis, adjusts aphtha, is managed pharyngalgia, promoting lactation, flat acute mastitis, Xie Huozhuo, is treated
Metal-inflicted wound.
Conic gymnadenia tuber：For orchid hand ginseng and the stem tuber of gymnadenia crassinervis Finet.Alias：Gymnadenia conopsea, palm ginseng（《Ningxia Chinese herbal medicine hand
Volume》）, hand ginseng（《Shaanxi Chinese herbal medicine》）, prosperous drawing（Hide name）.It is sweet, it is mild-natured.Major function tonifying Qi and blood, promotes the production of body fluid to quench thirst.Control lung
Empty cough and asthma, consumptive disease are become thin, and neurasthenia, chronic diarrhea, are lost blood, and under band, breast is few, chronic hepatitis.《Northeast medicine plants will》：Mucus is made,
Under being poisoned and rushing down；Steep in wine as strong, essence-replenishing preparation.《Heilungkiang Chinese medicine among the people》：Steep in wine and control impotence.《Middle traditional Chinese medicines plant illustrated handbook》：
Dispersing blood stasis, controls traumatic injury, and hematocele is not all right.《Often use Chinese herbal medicine in Sichuan》：Enriching the blood and tonifying qi, promote the production of body fluid to quench thirst.Deficiency syndrome of the lung cough and asthma is controlled, consumptive disease is won
It is thin, hypogalactia juice.《Shaanxi Chinese herbal medicine》：Strengthening by means of tonics, tonifying spleen moistening lung, calm the nerves relieving convulsion, QI invigorating analgesic.Control in poor health, nerve declines
It is weak, internal lesion caused by overexertion, cough, asthma.
Chinese cassia tree：It is acrid flavour, sweet, it is warm-natured.The thoughts of returning home, lung, bladder warp.Major function：Complement sun, warming spleen and stomach, removing internal cold, leads to blood
Arteries and veins.Control the Yang-function insufficiency of kidneyzang, cold weak pulse of limb, yang depletion collapse, diarrhea of suffering from abdominal pain, cold hernia run quickly globefish, waist and knee crymodynia, Amenorrhea abdominal mass, cloudy subcutaneous ulcer, stream
Note, and empty sun are floating more, heat in the upper and cold in the lower.《This warp》：Your Majesty's gas cough is inverse, and knot gas larynx numbness tells suction, sharp joint, tonifying middle-Jiao and Qi.《Do not record》：
Master is pained, coerces wind, hypochondriac pain, warm muscle, promotes blood circulation, and is only tired of, perspires.Main middle benefit gas, benefitting liver and lung gas, trusted subordinate's fever and chills, cold disease, choleraic myospasm,
Headache, pain in the back, only saliva, cough , Bi Weng：It can have an abortion, hard joint, promoting blood circulation, manage and dredge deficiency；A surname leads hundred medicines, without being feared.《Solar corona
Sub- book on Chinese herbal medicine》：All general mood are controlled, mend general debility, leads to nine orifices, sharp joint, strengthening the essence, improving eyesight, warms up waist and knee, break Xuan addiction abdominal mass, dispersing blood stasis
Blood, control wandering arthritis joint contracture, continuous muscles and bones, myogenic meat.《Medicine origin》：Lower burnt deficiency is mended, controls that heavy cold shoulder is cold and exterior deficiency spontaneous perspiration.
《Cure mainly secret want》：Ooze and let out, quench the thirst.Wang Haogu：Mend gate of vitality's deficiency, boosting source of fire for eliminating abundance of yin.
Embodiment
With reference to embodiment, the present invention is further described.
Embodiment 1：The preparation of capsule
Each raw material is weighed by following weight：Dogwood fruit 400g, Semen Ziziphi Spinosae (parched) 150g, raw and fried 150g, coptis 60g, meat
Osmanthus 40g, donkey-hide gelatin 120g, Ligusticum wallichii 250g, raw oyster 250g, Poria cocos 150g, wind-weed 150g, gypsum 250g, conic gymnadenia tuber 150g, the fennel heart
Careless 150g.
(1) dogwood fruit, raw oyster, Poria cocos, the wind-weed, gypsum, Rhodobryum giganteum are extracted into secondary, first time plus 8 times of weights of water with water
Amount, decoct 2 hours, second plus 6 times of weight of water, decoct 1 hour；Decoction liquor is merged, filtered, filtrate is concentrated into relative density
For 1.30-1.35 (55 DEG C) clear cream, it is dried under reduced pressure, it is standby；
It is (2) coptis, conic gymnadenia tuber, Chinese cassia tree, Ligusticum wallichii, Semen Ziziphi Spinosae (parched) and raw and fried is secondary with 6 times of amount 80% ethanol extractions,
1 hour every time, extract solution recovery ethanol, concentration, it is dried under reduced pressure, it is standby；
(3) it is well mixed after donkey-hide gelatin is crushed with the product obtained by step (1) and (2), adds appropriate dextrin, is mixed
Even, dry-pressing is into particle, and filling into capsule 1000, every fills 0.5g, produces.
Embodiment 2：The preparation of capsule
Composition：Dogwood fruit 300g, Semen Ziziphi Spinosae (parched) 100g, raw and fried 100g, coptis 80g, Chinese cassia tree 30g, donkey-hide gelatin
100g, Ligusticum wallichii 200g, raw oyster 200g, Poria cocos 120g, wind-weed 120g, gypsum 200g, conic gymnadenia tuber 120g, Rhodobryum giganteum 120g.
Preparation technology：
(1) coptis, conic gymnadenia tuber, Chinese cassia tree, Ligusticum wallichii, Semen Ziziphi Spinosae (parched) and raw and fried are added into the amount extraction 2 times of 8 times of 70% ethanol,
1.5 hours every time, filter, after filtrate recycling ethanol, be concentrated into relative density 1.08~1.12（60℃）, it is spray-dried and is made thin
Powder is standby；
(2) dogwood fruit, raw oyster, Poria cocos, the wind-weed, gypsum, Rhodobryum giganteum are added into 10 times of water amount extraction 2 times, 1 hour every time,
Filtration, filtrate are concentrated into relative density 1.08~1.12（60℃）, it is standby to be spray-dried obtained fine powder；
(4) alcohol extract spray drying fine powder, Aqueous extracts spray drying fine powder, gelatin powder 100g is taken to be pelletized after mixing, it is filling,
Capsule 1000 is made, produces.
Embodiment 3：The preparation of powder
Each bulk drug is weighed by following weight：The g of dogwood fruit 200, the g of Semen Ziziphi Spinosae (parched) 50, the g of raw and fried 50, the coptis 30
G, the g of Chinese cassia tree 4, the g of donkey-hide gelatin 70, the g of Ligusticum wallichii 150, the g of raw oyster 150, the g of Poria cocos 100, the g of the wind-weed 100, the g of gypsum 10, conic gymnadenia tuber
100 g, the g of Rhodobryum giganteum 100；After above-mentioned each bulk drug is crushed, 80 mesh sieves are crossed, subpackage dress, are produced.
Embodiment 4：The preparation of granule
(1) each raw material is weighed by following weight：Dogwood fruit 300g, Semen Ziziphi Spinosae (parched) 100g, raw and fried 100g, the coptis
80g, Chinese cassia tree 30g, donkey-hide gelatin 100g, Ligusticum wallichii 200g, raw oyster 200g, Poria cocos 120g, wind-weed 120g, gypsum 200g, conic gymnadenia tuber
120g, Rhodobryum giganteum 120g；
(2) dogwood fruit, raw oyster, the wind-weed, gypsum, Rhodobryum giganteum are extracted into secondary, first time plus 10 times of weight of water with water,
Decoct 2 hours, second plus 8 times of weight of water, decoct 1 hour；Filtration, it is 1.30-1.35 (55 that filtrate, which is concentrated into relative density,
DEG C) clear cream；It is dried under reduced pressure, it is standby；
(4) coptis, conic gymnadenia tuber, Chinese cassia tree, Ligusticum wallichii, Semen Ziziphi Spinosae (parched) and raw and fried are extracted with 60% ethanol, extract solution returns
It is dried under reduced pressure after receiving ethanol concentration, it is standby；
(5) it is well mixed, adds solvable with the product obtained by step (2), (3) and (4) after crushing donkey-hide gelatin and Poria cocos
Property starch, sucrose, mix, dry, crush, plus appropriate amount of ethanol particle is made, dry, whole grain, packing, be made 1000 bags, produce.
Embodiment 5：Clinical research is tested
First, clinical data
The patient 103 with complete data is chosen, is divided into two groups immediately, treatment group 52, man 26, female 26
Example, age 22-55 year, average age 41 years old, the course of disease 2 months to more than 10 years.Control group 51, man 25, female 26 are average
43 years old age, the course of disease 1 month to 11 years, in sex, age, the course of disease etc. without significance difference before two groups of case treatments
It is different, there is comparativity.
Case selection：Fall ill nervous breakdown of the selection using insomnia and dreamful sleep as main symptom, and exclude the serious heart, liver, kidney, brain
Etc. organic disease.Differential diagnosis in tcm belongs to (1) type of failure of the heart and kidney integrating：Dysphoria and insomnia, dreaminess, dizziness, tinnitus, palpitaition, forgetful, dry
Few Tianjin, soreness of the loins and nocturnal emission or aphthae, red tip of tongue, thready rapid pulse.(2) type of deficiency of heart-QI and gallbladder-QI：Have a sleepless night and palpitaition is timid, shortness of breath and lassitude,
Pale tongue, thready rapid pulse.(3) type of deficiency of both the heart and spleen：Insomnia and dreamful sleep and palpitaition are point forgetful, have a dizzy spell, god is tired, lustreless complexion, tongue it is thin it is white,
Arteries and veins is thin and delicate.
The course for the treatment of and points for attention：With two weeks for a course for the treatment of, every group of case needs to take a course for the treatment of just to be remembered two groups of patients
Entering and count case, taboo takes sleeping class medicine, in order to avoid influence the accuracy of observation result.Observation index：All cases are with insomnia
Dreaminess is main symptom, with reference to tongue picture, pulse condition collectively as observation index, and carries out classification observation.Neurasthenic other symptoms are
Secondary card.It is dizzy, brain is swollen, fidgety irritability, forgetful palpitaition, spiritlessness and weakness etc., the change to secondary card is with (-) (+) (++) table
Show.(-) is normal, and (+) is normal, and (++) is severe.
Insomnia classification：(1) 0 grade：It is asymptomatic.(2) I levels：Difficulty falling asleep, about half an hour is needed to fall asleep, or the length of one's sleep is short, wakes up
Afterwards feel body it is lighter, or sleep but not soundly, when wake up when sleep, wake up after easily fall asleep.(3) II levels：Difficulty falling asleep, toss about, need
More than half an hour can fall asleep, early awakening, wake up after feel drowsy, fatigue and weak or sleep it is shallow, when wake up when sleep, wake up after it is more difficult enter
Sleep.(4) III levels：Lie awake all night or sleep and dreaminess, be sleep it is non-sleep or have not enough sleep 3-4 hours, though have sleep weak, head
The symptoms such as dizzy brain is swollen are not improved.
Have a dream and be classified：(1) 0 grade：Without dream or few dream.(2) I levels：Have a dream more.(3) II levels：Have a dream more, it is still drowsy after waking up.
(4) III levels：Dreamland is diverse and confused, drowsy after waking up.
2nd, test method
Control group：Ganoderma lucidum slice, one time three, three times per day.
Treatment group：Capsule prepared by the embodiment of the present invention 2；Orally, one time 5,3 times on the one.
3rd, curative effect determinate standard：
Cure：It is 0 grade that insomnia, which is had a dream,.It is effective：Insomnia, which is had a dream, to be improved more than two level, or insomnia daydream improves one-level, secondary card
There are disappearances more than half.Effectively：Insomnia, which is had a dream, to be improved more than one-level, the insufficient half of secondary card disappearance.It is invalid：Insomnia daydream nothing changes
It is kind.Therapeutic evaluation is carried out according to curative effect judging standard, the results are shown in Table 1.
The clinical treatment outcome table of the present invention of table 1
| Group | Number of cases | Recovery from illness | It is effective | Effectively | It is invalid | It is efficient（%） |
| Treatment group | 53 | 32(60.4) | 14(26.4) | 6(11.3) | 1(1.9) | 98.10% |
| Control group | 52 | 18(34.0) | 12(12.6) | 14(26.4) | 8(15.1) | 84.90% |
Treatment group totally 53, wherein recovery from illness 32, accounts for 60.4%；Effective 14, account for 26.4%；Effective 6, account for 11.3%；Nothing
Effect 1, accounts for 1.9%, total effective rate 98.1%；And the total effective rate of control group is 84.9%；Two groups are compared, and difference has very
Significant meaning (P ＜ 0.005).
Embodiment 6：Model case
1st, certain is permitted, male, teacher is 47 years old, long-term overworked, suffers from neurasthenic syndrome, palpitaition, giddy, has a sleepless night, receives
Difference, expression are depressed, cold perspiration, and red tongue body, moss thin yellow Tianjin are few, and the thin and delicate slightly string of arteries and veins is slided.Urine is yellow few, and stool is scorching, belongs to heart temper
The empty and deficiency of liver-yin and kidney-yin, system are returned.Take capsule of the present invention slept after 2 months it is i.e. normal, it is dizzy once in a while, take medicine 3 months and fully recover, half
Follow-up is not recurred after year.
2nd, Zhang, female, 18 years old, high school senior, when upper high three, there is neurasthenia, palpitaition, weak, insomnia, night sweat, receive
Difference, irregular menstruation, the self-induction heart is timid, once repeatedly carrys out City Hospitals and goes to a doctor, and takes the medical treatment such as amino acid, creatinine, vitamin, has no bright
Effective fruit.Tcm diagnosis and treatment, card are shown in：Red tongue body, moss thin yellow and it is dry, wiry and rolling pulse is slightly counted accurately.It is sick after 10 days to take capsule of the present invention
Feelings are taken a turn for the better, and the symptom such as weak, tired lazy speech of god is still deposited, rear state of an illness complete incidence graph after 2 months, and is smoothly admitted to preferable university.So far
No relapse.
3rd, Lee, man 21 years old, in March, 2013 goes to a doctor, and the patient once suffered from nervous breakdown before 3 years, night chronic insomnia,
Palpitaition, it is difficult to fall asleep, or through taking sedative, after sleep thus palpitaition and wake up with a start, be once repeatedly diagnosed as that " nerve declines to examination in hospital
It is weak " and oryzanol is largely taken, the drug therapy of the regulation nervous function such as vitamin C, vitamin B1, stable is showed no improvement,
The state of an illness is further serious in nearly one month, phenomenon that is vexed and lying awake all night so far occurs and requires traditional Chinese medical herbal treatment.Symptom：The heart
Tired, insomnia, headache are such as split, difficulty falling asleep, easily wake up with a start, palpitaition, dizziness and tinnitus, soreness and weakness of waist and knees, forgetful something lost dream.Dry mouth and lack of saliva, tongue
Matter is red, yellow and greasy fur.Take capsule of the present invention after 1 month all symptoms mitigated, sleep returns to normal, sick after 3 months
Feelings complete incidence graph.Recurrence that so far there are no.
Claims (7)
1. a kind of Chinese medicine composition for treating neurasthenia sleep-disorder, it is characterised in that by each bulk drug of following parts by weight
It is made：Dogwood fruit 20-40 parts, Semen Ziziphi Spinosae (parched) 5-15 parts, raw and fried 5-15 parts, coptis 3-6 parts, Chinese cassia tree 0.4-4 parts, donkey-hide gelatin 7-
12 parts, Ligusticum wallichii 15-25 parts, raw oyster 15-25 parts, Poria cocos 10-15 parts, wind-weed 10-15 parts, gypsum 15-25 parts, conic gymnadenia tuber 10-
15 parts, Rhodobryum giganteum 10-15 parts.
2. according to the Chinese medicine composition described in claim 1, it is characterised in that the parts by weight of each bulk drug are：30 parts of dogwood fruit,
10 parts of Semen Ziziphi Spinosae (parched), 10 parts of raw and fried, 8 parts of the coptis, 3 parts of Chinese cassia tree, 10 parts of donkey-hide gelatin, 20 parts of Ligusticum wallichii, 20 parts of raw oyster, Poria cocos 12
Part, 12 parts of the wind-weed, 20 parts of gypsum, 12 parts of conic gymnadenia tuber, 12 parts of Rhodobryum giganteum.
3. according to the Chinese medicine composition described in claim 1 or 2, it is characterised in that：It is prepared into according to Chinese medicine preparation and clinically fits
Suitable preparation.
4. according to the Chinese medicine composition described in claim 3, it is characterised in that：Described preparation includes capsule, pill, dissipated
Agent, granule, tablet, oral liquid or pill.
A kind of 5. method for preparing the Chinese medicine composition described in claim 1 or 2, it is characterised in that：Weighed by the parts by weight
Each bulk drug；Each bulk drug is crushed, sieved, the auxiliary material or excipients needed for preparations shaping is added, is prepared into capsule, tablet
Or pill.
A kind of 6. method for preparing the Chinese medicine composition described in claim 1 or 2, it is characterised in that comprise the following steps：
(1) each bulk drug is weighed by the parts by weight；
(2) dogwood fruit, raw oyster, Poria cocos, the wind-weed, gypsum, Rhodobryum giganteum are extracted twice with water, merges aqueous, be concentrated under reduced pressure, will
Concentrate is spray-dried, standby；
(3) coptis, conic gymnadenia tuber, Chinese cassia tree, Ligusticum wallichii, Semen Ziziphi Spinosae (parched) and raw and fried are extracted twice, by ethanol with 40-80% ethanol
After extract solution recovery ethanol, spray drying is standby；
(4) it is well mixed after donkey-hide gelatin is crushed with the product obtained by step (2) and (3), adds pharmaceutical preparation auxiliary materials and mixing system
Finished dosage form is made into intermediate formulations, then through preparations shaping technique.
7. the Chinese medicine composition described in claim 1 or 2 is preparing the application in treating neurasthenia sleep disorder remedies.
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1907406A (en) * | 2006-08-09 | 2007-02-07 | 黄志良 | Decoction preparation for treating asomnia of protracted disease intruding into collateral and its preparation process |
| CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
| CN101822775A (en) * | 2010-05-07 | 2010-09-08 | 成都海旺科技有限责任公司 | Traditional Chinese medicinal composition for treating insomnia |
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|---|---|---|---|---|
| CN1907406A (en) * | 2006-08-09 | 2007-02-07 | 黄志良 | Decoction preparation for treating asomnia of protracted disease intruding into collateral and its preparation process |
| CN101396512A (en) * | 2008-10-15 | 2009-04-01 | 黄建国 | Traditional Chinese medicine formulation for treating insomnia |
| CN101822775A (en) * | 2010-05-07 | 2010-09-08 | 成都海旺科技有限责任公司 | Traditional Chinese medicinal composition for treating insomnia |
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