CN104645244A

CN104645244A - Traditional Chinese medicine composition for treating atherosclerosis

Info

Publication number: CN104645244A
Application number: CN201510110696.8A
Authority: CN
Inventors: 朱延朋; 陶雪梅
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-03-14
Filing date: 2015-03-14
Publication date: 2015-05-27

Abstract

The invention provides a traditional Chinese medicine composition for treating atherosclerosis. According to the invention, mulberry, sophora japonica, lotus stamen, dodder seed, aconite root, black sesame, altai anemone rhizome, intermediate peashrub flower, caulis spatholobi, trogopterus dung, ageratum, achyranthes and donkey-hide gelatin are used in the raw material medicine as monarch and adjuvant drugs for preventing and treating atherosclerosis, complex pulse and depletion, reinforcing liver and kidney, nourishing blood and brain, dispelling cold and relieving pain; auxiliary choerospondias fruit, ginseng flower, lily, gingko leaf, flos albiziae, radix linderae leaf, desertliving cistanche, longan pulp, salvia miltiorrhiza, curcuma root, fresh pears, oranges, lemons and royal jelly are used as auxiliary drugs to enhance effects of the monarch-and-adjuvant drugs, so as to tranquilize mind by nourishing the heart, replenish body vitality, restore physical strength and improve immunity; and combination of the drugs has better effects in preventing and treating symptoms of patients with atherosclerosis, reducing or inhibiting systemic reactions, protecting functions of various organ systems, nourishing the five internal organs and reinforcing yin and the essence.

Description

A kind of Chinese medicine composition for the treatment of arteriosclerosis

Technical field

The present invention relates to the medicinal preparation containing deriving from plant, animal or raw mineral materials, particularly a kind of Chinese medicine composition for the treatment of arteriosclerosis and preparation method thereof.

Background technology

Arteriosclerosis is a kind of non-inflammation pathological changes of tremulous pulse, ductus arteriosus wall can be made to thicken, hardening, follows the string, luminal stenosis.Arteriosclerosis be with age and occur angiopathy, its rule normally adolescence occur, increase the weight of period to person in middle and old age, fall ill.Male is many compared with women, and primary disease increases gradually in China in recent years, becomes one of old people's main cause of death.

Clinical manifestation: arteriosclerotic performance depends mainly on the degree of ischemia of vascular lesion and afflicted organ, for early stage arteriosclerotic, Most patients nearly all without any clinical symptoms, development of hiding under being all in concealment state.For the arteriosclerotic in mid-term, the clinical symptoms such as Most patients all more or less listless and aching, the limping of had palpitation, chest pain, uncomfortable in chest, headache, dizziness, the cool fiber crops of extremity, extremity, vision reduction, hypomnesis, insomnia and dreamful sleep, different patients has different symptoms.Generally show as mental and flag, palpation body surface artery is as elongated, tortuous and hardening in Temporal Artery, radial artery, brachial artery etc. can find to broaden.

The traditional Chinese medical science thinks that many and inward invasion of pathogenic cold occur this disease, drinking and eating irregularly, and feelings will is forfeited one's integrity, and overstrain internal injury, the factors such as body deficiency due to old age are relevant, and pathogenesis has deficiency and excess two aspect.Show as: suffocating pain over the chest, very then chest pain radiating to the back, failing to sleep due to dyspnea is main symptom, or uncomfortable in chest, and breathe and owe smooth, severe one then has chest pain, severe patient chest pain radiating to the back, backache radiating to the heart.Stringy pulse or knot generation.

1. the cause of disease

(1) inward invasion of pathogenic cold is trembled with fear main spasm, and containment yang-energy, makes hematogenous blockage, sends out as primary disease

(2) drinking and eating irregularly intemperance of taking food, surfeit delicious food savoury, or be addicted to drink addicted to cigarette, cause spleen gastric injury, transporting is lacked of proper care, accumulatively wet raise phlegm, and upper criminal ambition, checks heart-yang, functional activity of QI being not smooth, blockage of the cardiac vessels and send out for this reason sick.

(3) feelings will is forfeited one's integrity melancholy impairing the spleen, dysfunction of the spleen in transportation, poly-ly wets into expectorant; Depressed rage impairing the liver, the irritability stasis of blood is stagnant, very then stagnated QI transforming into fire, fluid transformed into phlegm by fire.The stagnation of QI and stagnation of phlegm all can make hematogenous blockage, blockage of the cardiac vessels, and send out as the thoracic obstruction.

(4) overstrain internal injury overstrain impairing the spleen, insufficiency of the spleenlose fortune, QI and bloodization is raw passive, and heart arteries and veins loses supports and the thoracic obstruction; Or impairment of YANG of being overworked for a very long period, heart kidney yang is micro-, and agitate unable, Xiong Yang is depressed, invades in YIN-cold, hematogenous blockage and sending out as the thoracic obstruction.

(5) body deficiency due to old age is over fifty, kidney qi from half, essence and blood degradation, insufficiency of kidney-YANGdecline, then can not inspire YANG of five ZANG-organs, deficiency of kidney-YIN, then can not moisten foster the five internal organs, heart arteries and veins loses to be sent out as the thoracic obstruction in replenishing vital QI with drugs of warm nature.

2. pathogenesis

The main pathogenesis of the thoracic obstruction is blockage of the cardiac vessels, and sick position is the heart, relates to liver, spleen, kidney, and lung etc. are dirty.The heart, liver,spleen,kidney, pulmonary air blood negative and positive are not enough, and heart arteries and veins loses supports, not Rong Ze pain, the numbness resistance heart arteries and veins such as the stagnation of QI, blood stasis, cold coagulation, phlegm-damp, stagnation of QI and blood may bring about pain.

Traditional Chinese medicine does not propose the concept of " arteriosclerosis ".The nomenclature principle of traditional Chinese medical science disease mainly with the cause of disease, pathogenesis, pathological product, sick position, primary symptom, sign for foundation.At Chinese medicine medium-sized artery sclerosis many genus " thoracic obstruction " category, the advantage of Chinese traditional treatment arteriosclerosis is that effect is better than simple western medical treatment, and life in patients is higher, and life span is also longer.

Summary of the invention

Technical problem to be solved by this invention is, provides that a kind of formula is simple, processing technology is easy, and the little and convenient drug administration of toxic and side effects, medicament is easy to manufacture, new drug with low cost.The present invention has enriching yin boost qi, blood circulation and channel invigorating, nourish heart effect that is active, warmly nourishing Yangqi; mainly for the discomfort of arteriosclerosis patient; the treatment of whole body relevant disease effectively can be taken into account while improving promoting extremities blood circulation; good prevention effect is had to the arteriosclerosis of whole body, angiostenosis; good protective effect is had to vitals such as the heart, brain, kidneys; be formed with very important effect to what prevent and treat coronary heart disease, myocardial infarction and cerebral thrombosis, improve the quality of life of patient.The present invention adopts the Chinese crude drug of different properties, has carried out scientific compatibility, and can reach desirable therapeutic effect, safety, processing technology is easy, and toxic and side effects is little, and convenient drug administration, medicament is easy to manufacture, with low cost.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of arteriosclerosis, its crude drug is with Fructus Mori, Flos Sophorae, Stamen Nelumbinis, Semen Cuscutae, Radix Aconiti Lateralis Preparata, Semen Sesami Nigrum, Rhizoma Anemones Altaicae, Flos Caraganae intermediae, Caulis Spatholobi, Oletum Trogopterori, Herba Pogostemonis, Radix Achyranthis Bidentatae, arteriosclerosis prevented and treated by the medicine that Colla Corii Asini is the monarch and his subjects, multiple arteries and veins takes off admittedly, the liver and the kidney tonifying, nourish blood beneficial brain dispersing cold for relieving pain, with Fructus Choerospondiatis, Flos Ginseng, Flos Lilii viriduli, Folium Ginkgo, Flos Albiziae, Folium Linderae strychnifoliae, Herba Cistanches, Arillus Longan, Radix Salviae Miltiorrhizae, Radix Curcumae, fresh pears, Fructus Citri tangerinae, Fructus Citri Limoniae and the medicine of Lac regis apis for assisting a ruler in governing a country, strengthen effect of monarch-minister drug, tranquilizing by nourishing the heart, supplement vitality of human body, regain one's strength, improve immunity, all medicines share better prevents and treats arteriosclerosis patients symptomatic, alleviate or suppress general reaction, protect each tract function, support the five internal organs, YIN nourishing benefit vital essence.

The property of medicine and the pharmacology of medicine selected by the present invention are respectively:

Fructus Mori:

[nature and flavor] are sweet, are slightly cold; GUIXIN, liver, kidney channel.

[function cures mainly] controls hepatic and renal YIN deficiency, sends and takes off, constipation, and order is dark, tinnitus, former infections, articular instability.It is improved skin (comprising scalp) blood supply, nutrition skin, makes the effects such as the delicate and black hair of skin, and can slow down aging.Fructus Mori is that middle-aged and elderly people is healthy and strong U.S. face, antidotal good fruit and good medicine.Normal food Fructus Mori can improving eyesight, the symptom that relieving eye strain is dry and astringent.Fructus Mori has immunologic enhancement.Fructus Mori has effect of gain to spleen, has potentiation, can prevent human body to hemolytic reaction arteriosclerosis, skeletal joint sclerosis, promote metabolism; Fructus Mori can promote erythrocytegrowth, prevent leukocytereduce, and to treatment diabetes, anemia, hypertension, hyperlipidemia, coronary heart disease, neurastheniaetc. disease, there is auxiliary curative effect.Fructus Mori has the effects such as promoting the production of body fluid to quench thirst, facilitating digestion, help defecation, and proper amount of edible can promote gastric secretion, stimulates enterokinesia and removes scorching.The traditional Chinese medical science is thought, Fructus Mori is sweet in flavor and cold in property, there is the liver and the kidney tonifying, intestine moistening of promoting the production of body fluid, the effect such as black hair improving eyesight.

Flos Sophorae: nature and flavor with return through: bitter in the mouth, be slightly cold.Return liver, large intestine channel.Function with cure mainly: cooling blood for hemostasis, blood pressure lowering.For spitting blood, have blood in stool, bleeding hemorrhoids, hematuria metrorrhagia, hypertension.Suitable amount used externally.Many parch to black that stops blooding are used; The many raw use of expelling phlegm for arresting cough.

Stamen Nelumbinis:

[nature and flavor] are sweet, puckery, flat.

[return through] GUIXIN, kidney channel.

[function cures mainly] reinforcing the kindey to control nocturnal emission.For emission and spermatorrhea, leukorrhagia, urinefrequently.

Semen Cuscutae:

[nature and flavor] Gan Xinping, enters liver, kidney channel.

[function cures mainly] the kidney invigorating and essence nourishing, nourishing the liver to improve visual acuity, antiabortive.For caused by liver and kidney deficiency, soreness of waist and knee joint, impotence and seminal emission, frequent urination and enuresis, two blurred visions are dark, the diseases such as frequent fetal movement.

Radix Aconiti Lateralis Preparata:

[nature and flavor] are pungent, sweet, hot greatly; Poisonous; GUIXIN, kidney, spleen channel.

[function] recuperating depleted YANG and rescuing the patient from collapse, mend fire supporing yang, dispersing cold for relieving pain." for recuperating depleted YANG and rescuing the patient from collapse first product medicine "

[curing mainly] for excessive YIN keeping YANG externally, profuse sweating yANG-depletion, vomiting and diarrhoea, it is inverse to faint, cold extremities faint pulse, trusted subordinatecold type of pain, cold-dysentery, beriberi edema, anemofrigid-damp arthralgia, sexual impotence, cold womb, deficiency and coldnessvomit and diarrhoea, YIN-cold edema, yang deficiency diseases caused by exogenous pathogenic factor, the disease of carbuncle of yin nature skin infection and all chronic diseaseses.

Semen Sesami Nigrum:

[nature and flavor] are flat, sweet in the mouth.

[effect] invigorating the liver and kidney, benefiting essence-blood, intestine moistening is dry; For dizziness and blurred vision, Hiccough and deaf, early whitening of beard and hair, post disease alopecia, dryness of the intestine constipation.

Rhizoma Anemones Altaicae:

[meridian distribution of property and flavor] is pungent, temperature.

[function cures mainly] has expectorant of having one's ideas straightened out, the function of being amusing of calming the nerves., inappetence vexed for calentura stupor, epilepsy, neurosis, Hiccough and deaf, breast abdominal distention.Carbuncle skin ulcer tinea is controlled in external.

Flos Caraganae intermediae:

[nature and flavor] are sweet, temperature.

[function cures mainly] nourishing YIN and benefiting blood.Control hypertension, dizziness.

Caulis Spatholobi:

[meridian distribution of property and flavor] is bitter, sweet, temperature.Return liver, kidney channel.

[function cures mainly] enriches blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

Oletum Trogopterori:

[nature and flavor] are sweet, temperature.

[function cures mainly] promoting blood circulation to remove blood stasis, parch to black stops blooding.Have a pain for trusted subordinate's congestion, dysmenorrhea, blood stasis amenorrhea, puerperal abdominalgia with blood stasis; Parch to black controls metrostaxis; Traumatic injury is controlled in external, Serpentis, insect bite wound.It is logical that Oletum Trogopterori hardship lets out temperature, and " tonneau gaseous pulse ", " general rule is not bitterly.”

Herba Pogostemonis: pungent, tepor.Return spleen, stomach, lung meridian.Function cures mainly: eliminating turbid pathogen with aromatics, and appetizing preventing or arresting vomiting, delivers expelling summer-heat.For turbid damp obstructing in middle-JIAO, gastral cavity painful abdominal mass is vomitted, and heat-damp in summer asthenia is not uncomfortable in chestly relaxed, and cold-damp closes summer-heat, and stomachache is vomited and diarrhoea, nasosinusitis headache." kind reason Central Region turbid damp sputum, is fast stomach of being amusing, vibrates clear positive quality goods for Herba Pogostemonis, delicate fragrance tepor." not Lu " controls the swollen person of edema due to wind pathogen poison, and dispel turbid damp, self energy clear the course also.1. the effect of antifungic action 2. anti-leptospira effect 3. antivirus action 4. pairs of digestive system.

Radix Achyranthis Bidentatae:

[meridian distribution of property and flavor] bitter in the mouth, acid, flat; Return liver, kidney channel.

[function cures mainly] invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea lump in the abdomen, dizziness due to hyperactivity of liver-YANG.

Colla Corii Asini:

[nature and flavor, return through] are sweet, flat.Return lung, liver, kidney channel.

[effect] enriches blood, hemostasis, nourshing Yin and drynsessmoistening prescription.

[composition] donkey skin.Adjuvant: crystal sugar, yellow wine, Oleum Glycines.

[character] this product is rectangle or square block, and pitchy is glossy.Matter is hard and crisp, and section light, fragment is looked in brown translucent illumination.Feeble QI, taste is micro-sweet.

[function cures mainly] to be enriched blood YIN nourishing, is moisturized, hemostasis.For blood deficiency and yellow complexion, dizzy cardiopalmus, dysphoria and insomnia, xeropulmonary cough.

Fructus Choerospondiatis:

[meridian distribution of property and flavor] sweet, acid, flat.

[function] circulation of qi promoting invigorate blood circulation, nourish heart, calm the nerves, anti- cardiac muscleischemia, the effects such as cardiac function protecting.For qi depression to blood stasis, the thoracic obstruction is had a pain, shortness of breath and palpitation, irritability.

Flos Ginseng:

[nature and flavor]: bitterness Hui Tian, have the pungent sweet taste of Radix Ginseng.

[function]: supplement vitality of human body, regain one's strength, strengthens body immunity.

Flos Lilii viriduli:

[nature and flavor] Bulbus Lilii sweet in the mouth, cold nature; GUIXIN, lung meridian.

[function cures mainly] nourishing YIN and moistening the lung, clearing away heart-fire for tranquillization.For deficiency of YIN chronic cough, sputum mixed with blood, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep, absentminded.Have nourishing YIN and moistening the lung cough-relieving effect, for the cough caused by dryness-heat of deficiency of lung-YIN, sputum mixed with blood, as all sorts of flowers cream.Control chronic cough of deficiency lung, chronic cough is spat blood, as baihe gujin decoction.Have clearing away heart-fire for tranquillization effect, unclear for calentura waste heat, fidgets due to deficiency is palpitated with fear, insomnia and dreamful sleep etc.

Folium Ginkgo:

[meridian distribution of property and flavor] bitter in the mouth, puckery, flat; The benefit heart is astringed the lung, removing dampness antidiarrheal.

[function cures mainly] is uncomfortable in chest pained, severe palpitation, and phlegm dyspnea is coughed, dysentery, leucorrhea.

Flos Albiziae:

There is calming effects, mainly control the effects such as pent-up is uncomfortable in chest, insomnia forgetfulness, nourishing YIN and invigorating YANG, ophthalmic, neurasthenia.Shu Yu, regulates the flow of vital energy, and calms the nerves, active.Control pent-up uncomfortable in chest, insomnia, forgetful, wind-fire ophthalmic, blurring of vision, pharyngalgia, carbuncle, traumatic injury pain.

Folium Linderae strychnifoliae:

[meridian distribution of property and flavor] is pungent, temperature enters lung, spleen, kidney three warp;

[effect] warming middle-JIAO, regulates the flow of vital energy, pain relieving.Control pathogenic cold in abdomen pain, the sliding number of urine, food stagnation, rheumatic arthritis.

Herba Cistanches:

[nature and flavor] are warm in nature, sweet in the mouth, salty;

[effect] supports the five internal organs, reinforcing YIN-essence, beneficial vital essence.

Arillus Longan:

[nature and flavor] are warm in nature, and taste is sweet.

[function cures mainly] invigorating the heart and spleen, nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency and yellow complexion.

Radix Salviae Miltiorrhizae:

[meridian distribution of property and flavor] is bitter, is slightly cold.GUIXIN, Liver Channel.

[function cures mainly] stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, clear away heart-fire relieving restlessness.For menoxenia, amenorrhea dysmenorrhea, lump in the abdomen, breast ventral spine pain, pyretic arthralgia pain, skin infection swells and ache, dysphoria and insomnia; Hepatosplenomegaly, angina pectoris." book on Chinese herbal medicine justice ": Radix Salviae Miltiorrhizae, being slightly cold of " herbal classic " meaning, TAO Hong-Jing has doubted it by mistake, and Miao's secondary alcohol also doubts it, and stupid to a stone is transform tepor into." herbal classic ": main trusted subordinate's pathogen, borborygmus are faint as leaked water, and cold and heat gather; Broken disease, except abdominal mass, stops stuffy sensation with restlessness, QI invigorating." WU Pu Bencao ": control cardiac and abdominal pain." not Lu ": nourish blood, remove trusted subordinate's obstinate disease stagnation of QI, stiffness along the spinal column, foot numbness; Except wind, Xing stays heat, takes sharp people for a long time.TAO Hong-Jing: stain beverage it, treat migratory arthralgia." property of medicine opinion ": control flaccidity of the lower limbs, pain numbness, main attacked by pestiferous factors; Control stomachache, gas is done sound ring and is shouted." Japan hanako materia medica ": sedate of reposing, tonneau GUAN-pulse.Control cold and hot labor, arthralgia, extremity are unsuccessful; Evacuation of pus pain relieving, granulation promoting is put on flesh; Broken stagnated blood, mends new hemopoietic; Peaceful tire, fall stillborn fetus; Under hemostasis metrorrhagia and leukorrhagia, adjust married woman's passages through which vital energy circulates irregular, blood evil thought is tired of; Malignant boil scabies, wart is gone to live in the household of one's in-laws on getting married toxic swelling, erysipelas; Headache, acute conjunctivitis, hot temperature is mad vexed." the southern regions of the Yunnan Province book on Chinese herbal medicine ": reinforcing the heart sedate, calming heart and tranquilizing mind.Control forgetful palpitation with a distress feeling, palpitation with fear is insomnia." detailed outline ": invigorate blood circulation, logical percardium.Control colic." choosing of Yunnan Chinese herbal medicine ": promoting blood circulation to remove blood stasis, sedation-analgesia.Control menoxenia, dysmenorrhea, rheumatic arthralgia, metrorrhagia, spit blood, mastitis, carbuncle.

Radix Curcumae:

[meridian distribution of property and flavor] is pungent, bitter, cold; GUIXIN, lung, Liver Channel.

[effect] promoting blood circulation and stopping pain, dispersing the stagnated live-QI to relieve the stagnation of QI, removing heat from blood clears away heart-fire, promoting the function of the gallbladder to alleviate jaundice.

Fresh pears:

[meridian distribution of property and flavor] sweet in the mouth is sour, cool in nature, enters lung, stomach warp;

[function] containing compositions such as more glycocide and tannic acids, can promote the production of body fluid, heat clearing away, expelling phlegm for arresting cough, have maintenance action to throat.

Fructus Citri tangerinae:

[function] has appetizing and regulates the flow of vital energy, effect of relieving cough and moistening lung, cures mainly very thirsty in septum pectorale stagnation of QI, mouth, cough due to lung-heat etc.

Fructus Citri Limoniae:

[meridian distribution of property and flavor] sour in the mouth is sweet, property is flat, enters liver, stomach warp.

[function] has preventing phlegm from forming and stopping coughing, promotes the production of body fluid, effect of spleen invigorating; Mainly treating bronchitis, pertussis, vitamin C deficiency, heatstroke excessive thirst, inappetence, pregnant woman's disorder of stomach-QI, poor appetite, eructation etc.

Lac regis apis:

[nature and flavor] sweet acid, flat.

[function cures mainly] nourishes, strong, the liver benefiting, spleen invigorating.Weak after curing the disease, infantile malnutrition, old asthenia, infectious hepatitis, hypertension, rheumatic arthritis, duodenal ulcer.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of arteriosclerosis, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Fructus Mori 10-20 part, Flos Sophorae 10-20 part, Stamen Nelumbinis 10-20 part, Semen Cuscutae 10-20 part, Radix Aconiti Lateralis Preparata 10-20 part, Semen Sesami Nigrum 10-20 part, Rhizoma Anemones Altaicae 10-20 part, Flos Caraganae intermediae 10-20 part, Caulis Spatholobi 10-20 part, Oletum Trogopterori 10-20 part, Herba Pogostemonis 10-20 part, Radix Achyranthis Bidentatae 10-20 part, Colla Corii Asini 10-20 part, Fructus Choerospondiatis 10-20 part, Flos Ginseng 10-20 part, Flos Lilii viriduli 10-20 part, Folium Ginkgo 10-20 part, Flos Albiziae 10-20 part, Folium Linderae strychnifoliae 10-20 part, Herba Cistanches 10-20 part, Arillus Longan 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Radix Curcumae 10-20 part, fresh pears 10-20 part, Fructus Citri tangerinae 10-20 part, Fructus Citri Limoniae 10-20 part, Lac regis apis 10-20 part.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of arteriosclerosis, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Fructus Mori 14-18 part, Flos Sophorae 14-18 part, Stamen Nelumbinis 14-18 part, Semen Cuscutae 14-18 part, Radix Aconiti Lateralis Preparata 14-18 part, Semen Sesami Nigrum 14-18 part, Rhizoma Anemones Altaicae 14-18 part, Flos Caraganae intermediae 14-18 part, Caulis Spatholobi 14-18 part, Oletum Trogopterori 14-18 part, Herba Pogostemonis 14-18 part, Radix Achyranthis Bidentatae 14-18 part, Colla Corii Asini 14-18 part, Fructus Choerospondiatis 14-18 part, Flos Ginseng 14-18 part, Flos Lilii viriduli 14-18 part, Folium Ginkgo 14-18 part, Flos Albiziae 14-18 part, Folium Linderae strychnifoliae 14-18 part, Herba Cistanches 14-18 part, Arillus Longan 14-18 part, Radix Salviae Miltiorrhizae 14-18 part, Radix Curcumae 14-18 part, fresh pears 14-18 part, Fructus Citri tangerinae 14-18 part, Fructus Citri Limoniae 14-18 part, Lac regis apis 14-18 part.

For solving the problems of the technologies described above, the invention provides a kind of Chinese medicine composition for the treatment of arteriosclerosis, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 16 parts, Fructus Mori, 16 parts, Flos Sophorae, Stamen Nelumbinis 16 parts, Semen Cuscutae 16 parts, Radix Aconiti Lateralis Preparata 16 parts, Semen Sesami Nigrum 16 parts, Rhizoma Anemones Altaicae 16 parts, Flos Caraganae intermediae 16 parts, Caulis Spatholobi 16 parts, Oletum Trogopterori 16 parts, Herba Pogostemonis 16 parts, Radix Achyranthis Bidentatae 16 parts, 16 parts, Colla Corii Asini, Fructus Choerospondiatis 16 parts, Flos Ginseng 16 parts, Flos Lilii viriduli 16 parts, Folium Ginkgo 16 parts, Flos Albiziae 16 parts, Folium Linderae strychnifoliae 16 parts, Herba Cistanches 16 parts, Arillus Longan 16 parts, Radix Salviae Miltiorrhizae 16 parts, Radix Curcumae 16 parts, fresh pears 16 parts, Fructus Citri tangerinae 16 parts, 16 parts, Fructus Citri Limoniae, Lac regis apis 16 parts.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of arteriosclerosis, and described Chinese medicine preparation dosage form is that the preparation method of capsule comprises:

Step a, puts into 10 times amount ethanol by Fructus Mori, Fructus Choerospondiatis, fresh pears, Fructus Citri tangerinae, Fructus Citri Limoniae, heating and refluxing extraction 2 times, each 1 ~ 2 hour, extracts active ingredient, is merged by 2 extracting solution and leaves standstill;

Step b, puts into 10 times of water gagings by surplus stock, heating and refluxing extraction 3 times, each 45 minutes ~ 1 hour, is merged by 3 extracting solution and leaves standstill;

Step c, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.One time four, three times on the one.

For solving the problems of the technologies described above, the present invention also provides a kind of preparation method for the treatment of the Chinese medicine composition of arteriosclerosis, and described Chinese medicine preparation dosage form is that the preparation method of oral liquid comprises:

Step b, by surplus stock medicine, is placed in decoction pot, first time adds 3 times of water gagings, soak 3 hours, decoct 20-30 minute, leach decocting liquid, second time adds 2 times of water gagings again, decoct 20-30 minute, twice decocting liquid mixing adjusted and add extracting solution subharmonic again in step a all afterwards, being concentrated into liquor strength is 0.4g crude drug/mL oral liquid, filling device bottle, obtains oral liquid.Each one of morning, noon and afternoon.

For solving the problems of the technologies described above, the present invention also provides a kind of dosage form for the treatment of the Chinese medicine composition of arteriosclerosis, and pharmaceutical dosage form can also be: sugar coated tablet, film coated tablet, enteric coated tablet, oral liquid, granule, electuary, powder, sublimed preparation, solution, suppository, plaster, syrup.

Detailed description of the invention:

Embodiment 1, formula: Fructus Mori 10g, Flos Sophorae 10g, Stamen Nelumbinis 10g, Semen Cuscutae 10g, Radix Aconiti Lateralis Preparata 10g, Semen Sesami Nigrum 10g, Rhizoma Anemones Altaicae 10g, Flos Caraganae intermediae 10g, Caulis Spatholobi 10g, Oletum Trogopterori 10g, Herba Pogostemonis 10g, Radix Achyranthis Bidentatae 10g, Colla Corii Asini 10g, Fructus Choerospondiatis 10g, Flos Ginseng 10g, Flos Lilii viriduli 10g, Folium Ginkgo 10g, Flos Albiziae 10g, Folium Linderae strychnifoliae 10g, Herba Cistanches 10g, Arillus Longan 10g, Radix Salviae Miltiorrhizae 10g, Radix Curcumae 10g, fresh pears 10g, Fructus Citri tangerinae 10g, Fructus Citri Limoniae 10g, Lac regis apis 10g;

Preparation method:

Treatment model case:

Lee, man, 50 years old, main cause " intermittent claudication increases the weight of 1 year in 5 years " is admitted to hospital.Before 5 years there is left lower extremity intermittent claudication in patient, and pulsation of foot dorsal artery disappears. walk about 300 meters.Go to a doctor and do color-Doppler ultrasound in locality province Grade A hospital and show: “ left popliteal artery Serious Stenosis, intra-arterial atherosclerosis plaque forming "; diagnosis " for left lower extremity atherosclerotic occlusive disease " gives operative treatment; postoperatively give oral invention formulation always; after 15 days, sign recovers normal; after consolidate one month again, do not recur so far.

Embodiment 2, formula: Fructus Mori 14g, Flos Sophorae 14g, Stamen Nelumbinis 14g, Semen Cuscutae 14g, Radix Aconiti Lateralis Preparata 14g, Semen Sesami Nigrum 14g, Rhizoma Anemones Altaicae 14g, Flos Caraganae intermediae 14g, Caulis Spatholobi 14g, Oletum Trogopterori 14g, Herba Pogostemonis 14g, Radix Achyranthis Bidentatae 14g, Colla Corii Asini 14g, Fructus Choerospondiatis 14g, Flos Ginseng 14g, Flos Lilii viriduli 14g, Folium Ginkgo 14g, Flos Albiziae 14g, Folium Linderae strychnifoliae 14g, Herba Cistanches 14g, Arillus Longan 14g, Radix Salviae Miltiorrhizae 14g, Radix Curcumae 14g, fresh pears 14g, Fructus Citri tangerinae 14g, Fructus Citri Limoniae 14g, Lac regis apis 14g.

Preparation method:

Treatment model case:

Sex: man, age: 52 years old.Medical history: December in 2014 evening on the 26th, middle appearance of sleeping is had palpitation, and getting up early feels that left hand left foot is numb, and left side speed of walking slows down, and is brain CT and does not find abnormal.The cervical vertebra both sides of feeling the 3rd day evening are very tight, and both shoulders are very heavy, and be again brain CT in time, result is without exception.Just occur current state subsequently: extremity are stiff, bent time length can not be stretched, and straight time length can not bend.Numb limbs and tense tendons is unable, and particularly sole numbness is walked unstable, dragging step walks, and two lower limb overweight two upper limb.Muscular tension is very high, tendon reflex extremely resist into, two forefoot is useless, does not stress.Finally be diagnosed as: arteriosclerosis, oral medicine of the present invention is after 14 days, and symptom is improved, and after two weeks, all diseases disappear, antisecosis, and spiritual pure, adheres to medication, consolidate curative effect, prevention of recurrence.Follow up a case by regular visits to and have no recurrence in more than 2 years.

Embodiment 3, formula: Fructus Mori 16g, Flos Sophorae 16g, Stamen Nelumbinis 16g, Semen Cuscutae 16g, Radix Aconiti Lateralis Preparata 16g, Semen Sesami Nigrum 16g, Rhizoma Anemones Altaicae 16g, Flos Caraganae intermediae 16g, Caulis Spatholobi 16g, Oletum Trogopterori 16g, Herba Pogostemonis 16g, Radix Achyranthis Bidentatae 16g, Colla Corii Asini 16g, Fructus Choerospondiatis 16g, Flos Ginseng 16g, Flos Lilii viriduli 16g, Folium Ginkgo 16g, Flos Albiziae 16g, Folium Linderae strychnifoliae 16g, Herba Cistanches 16g, Arillus Longan 16g, Radix Salviae Miltiorrhizae 16g, Radix Curcumae 16g, fresh pears 16g, Fructus Citri tangerinae 16g, Fructus Citri Limoniae 16g, Lac regis apis 16g.

Preparation method:

Treatment model case: patient marquis so-and-so, in 72 years old this year, suffering from the multiple diseases such as hypertension, diabetes, cholecystitis, cholelithiasis, all have plenty medicine everyday, is very painful.Medical history brief introduction: when January in this year, left foot starts pain, then occurred there is erosion between redness, toe, and pain is more than round the clock.To when districts and cities' hospitalize, be diagnosed as " vasculitis ", the treatment several months does not all feel any better.Then forward provincial hospital to, done B ultrasonic, contrast examination, be diagnosed as " double-legged arterial obliterans of lower extremity ", the amputation of suggestion corrective surgery.But family members considers old man's long life, postoperative life inconvenience, and limbs have been followed old man decades, can not accept inwardly and do not agree to amputation.After give oral Chinese medicine of the present invention after 40 days, symptom is improved, and two lower limb skin temperature color of the leather recovers normal, by original lame distance be 5 meters bring up to 600 meters after just there is symptom.Current patient actively prepares stem cell transplantation operation, sets up and enrich Doppler flow mapping around suffering limb blood vessel, fundamentally solves blood vessel ischemia problem, avoids Relapse rate to show effect.

Embodiment 4, formula: Fructus Mori 18g, Flos Sophorae 18g, Stamen Nelumbinis 18g, Semen Cuscutae 18g, Radix Aconiti Lateralis Preparata 18g, Semen Sesami Nigrum 18g, Rhizoma Anemones Altaicae 18g, Flos Caraganae intermediae 18g, Caulis Spatholobi 18g, Oletum Trogopterori 18g, Herba Pogostemonis 18g, Radix Achyranthis Bidentatae 18g, Colla Corii Asini 18g, Fructus Choerospondiatis 18g, Flos Ginseng 18g, Flos Lilii viriduli 18g, Folium Ginkgo 18g, Flos Albiziae 18g, Folium Linderae strychnifoliae 18g, Herba Cistanches 18g, Arillus Longan 18g, Radix Salviae Miltiorrhizae 18g, Radix Curcumae 18g, fresh pears 18g, Fructus Citri tangerinae 18g, Fructus Citri Limoniae 18g, Lac regis apis 18g.

Preparation method:

Treatment model case: female's Hao medical history brief introduction in 72 years old: right foot is sent out cool 3 months, occurs difficulty in walking afterwards, walk 300 meters afterwards sensation shank suppress swollen, occur pain at night, once defeated MAILUONING and Treated with Radix Salviae Miltiorrhizae, the state of an illness slightly takes a turn for the better.But pain increases the weight of after 10 days, night can only be interrupted sleep, carrys out my institute's treatment.Outpatient service is looked into: toes skin cyanosis color, and left first toe has a ulceration, and leg raising straight sag test is positive, and instep and posterior tibial artery are beaten faint, and blood glucose is not high.Diagnosis: atherosclerotic occlusive disease.Treatment: oral Chinese medicine preparation of the present invention, treat patient's transference cure after 21 days, healing is left hospital, after consolidate one month again, do not recur so far.

Embodiment 5, formula:

Fructus Mori 20g, Flos Sophorae 20g, Stamen Nelumbinis 20g, Semen Cuscutae 20g, Radix Aconiti Lateralis Preparata 20g, Semen Sesami Nigrum 20g, Rhizoma Anemones Altaicae 20g, Flos Caraganae intermediae 20g, Caulis Spatholobi 20g, Oletum Trogopterori 20g, Herba Pogostemonis 20g, Radix Achyranthis Bidentatae 20g, Colla Corii Asini 20g, Fructus Choerospondiatis 20g, Flos Ginseng 20g, Flos Lilii viriduli 20g, Folium Ginkgo 20g, Flos Albiziae 20g, Folium Linderae strychnifoliae 20g, Herba Cistanches 20g, Arillus Longan 20g, Radix Salviae Miltiorrhizae 20g, Radix Curcumae 20g, fresh pears 20g, Fructus Citri tangerinae 20g, Fructus Citri Limoniae 20g, Lac regis apis 20g.

Preparation method:

Model case: Zhang, be diagnosed as the mental disorder that cerebral arteriosclerosis occurs together for 50 years old, and always forget east at the beginning and forget west, buy vegetables and be not with money, go out and be not with key, these are all common occurrences.She became and more went against accepted conventions afterwards, was often will forget upper one minute next minute of what someone said.Household is afraid of dull-witted, and go to hospital to check, make a definite diagnosis: the mental disorder that cerebral arteriosclerosis occurs together, this disease needs most conditioning, and oral Chinese medicine preparation of the present invention 20 days symptoms are obviously improved, after consolidated again one month, rehabilitation, does not recur so far.

Pharmacological toxicity is tested

1, acute toxicity test

Application mice carries out acute toxicity testing and shows: Mouse oral gavage Chinese medicine preparation of the present invention, under 488.8g crude drug/kg dosage, after administration, mice occurs that light activity reduces, 1 hours recovers normal, Continuous Observation 7 days after administration, none animal dead, its overall health of patients, diet, take the photograph water, urine and body weight increase all normal, experimental result shows: the maximum dosage-feeding of Mouse oral gavage Traditional Chinese medicine preparation capsule agent of the present invention is 488.8g crude drug/kg/d (LD 50 > 488.8g crude drug/kg).Chinese medicine preparation clinical application every day total amount of the present invention is 0.1g crude drug/kg/d; By weighing machine, the dosis tolerata of mouse stomach Chinese medicine preparation of the present invention is 4888 times of clinical patient.Point out this medicine acute toxicity low, clinical drug safety.

2, long term toxicity test

Select SD rat, give the Chinese medicine preparation of the present invention of variable concentrations (18.0,6.0,2.0g crude drug/kg), every day gavage once, continuous 90 days, within after last administration 24 hours, respectively group is alive kills 1/2 animal (male and female half and half), and all the other 1/2 animals continue observations 2 weeks rear living and kill.Duration of test observes outward appearance, general behavior, food ration, the body weight change of animal, within after administration 90 days, within 2 weeks, carries out the index checking such as hematology's (RBC, HB, reticulocyte, PLT, CT, WBC and classification) and blood biochemical (AST, ALT, ALP, Glu, BUN, Crea, TP, T.BIL, ALB, CHOL), urine biochemistry, organ coefficient, histopathology with drug withdrawal.Result of the test shows: invention formulation is good at high, medium and low dosage treated animal general state, and outward appearance sign, behavioral activity, food-intake and body weight increase change all without exception; Three dosage groups and matched group hematological examination, blood biochemical analysis, urine biochemical analysis all in normal range, without significant difference between group; Each group of main organs histopathological examination shows no obvious abnormalities.These parameters drug withdrawal also had no change after 2 weeks.This test dosage is respectively 180,60,20 times of clinical medicine dose, rat is had no significant effect in high, medium and low three dosage (18.0,6.0,2.0g crude drug/kg) administration in continuous 90 days according to result of the test Chinese medicine preparation of the present invention, without clear and definite toxicity target organ and sensitive indicator, convalescent period observation also has no retardance toxic reaction, points out the dose safety of Chinese medicine preparation clinical practice of the present invention higher.

3, animal local excitation test:

The allergic reaction on guinea pigs of invention formulation and capsule Rat-rectum medication irritation test.Result shows: skin anaphylactic test, high dose group 0.8g (medicated powder)/kg, low dose group 0.1g (medicated powder)/kg, be equivalent to 20 times, 2.5 times that intend clinical people's consumption [0.04g (medicated powder)/kg] respectively, through percutaneous drug delivery, be showed no animal and produce allergy; Rectal application irritation test high dose group 5.0g (medicated powder)/kg, low dose group 3.2g (medicated powder)/kg, be equivalent to 125,80 times that intend clinical people's consumption respectively, mucous membrane of rectum is observed all without phenomenons such as hyperemia, edema in official hour, histopathologic examination compares no significant difference with blank group, have no and occur obvious irritative response, often organize its overall health of patients of Some Animals of retention, body weight, breathing, circulation, central nervous system and extremity are movable, equal Non Apparent Abnormality reaction.

Clinical data

1 object and method

1.1 accept arteriosclerosis patient for medical treatment, totally 105 examples.Wherein man 62 example, female 43 example, all meets arteriosclerosis diagnostic criteria.At random patient is divided into 2 groups: matched group and treatment group, treatment group 55 example, matched group 50 example, acquisition and recording patient physical data and state of an illness data after being admitted to hospital, adopts APACHE II standards of grading assess patient severity extent.Two groups of patient population data and APACHE II mark more equal no significant difference (P > 0. 05).

1.2 diagnostic criterias are with reference to clinical manifestation:

Arteriosclerotic performance depends mainly on the degree of ischemia of vascular lesion and afflicted organ, for early stage arteriosclerotic, Most patients nearly all without any clinical symptoms, development of hiding under being all in concealment state.For the arteriosclerotic in mid-term, Most patients all more or less listless and aching, the limping of had palpitation, chest pain, uncomfortable in chest, headache, dizziness, the cool fiber crops of extremity, extremity, vision reduction, hypomnesis, insomniathe clinical symptoms such as dreaminess, different patients has different symptoms.

Generally show as mental and flag, palpation body surface artery is as elongated, tortuous and hardening in Temporal Artery, radial artery, brachial artery etc. can find to broaden.

1.3 Therapeutic Method:

Treatment group: take oral liquid of the present invention, natural gift three times are taken, the morning, noon and afternoon you each one, 15 days courses for the treatment of, or take one time four, three times on the one, 15 days courses for the treatment of.

Matched group: oral folic acid, vitamin B12, extra-nutrition element.

1.4 efficacy assessment standards (1) clinical recovery: symptom, sign disappear, functional activity recovers normal, checks that indices recovers.(2) effective: symptom obviously alleviates.(3) effective: symptom alleviates slightly.(4) invalid: clinical symptoms, sign are without change.

I.5 statistical procedures uses SPSS 12.0 software to carry out statistical analysis, and ask that mean compares employing one factor analysis of variance for each group, group is asked and compared employing between two.Inspection.P<0.05 is that difference has significance.

2 results

Two groups of general curative effects compare, and the results are shown in Table 1.

A table 1 liang group general curative effect compares [example (%)]

Group	n	Cure	Effective	Effectively	Invalid	Total effective rate (%)
							Treatment group	55	14(25.5)	23(41.8)	12(21.8)	6(10.9)	49(89.1)
Matched group	50	8(16.0)	17(34.0)	15(30.0)	10(20.0)	40(80.0)

As can be seen from Table 1, adopt Chinese medicine preparation of the present invention can improve overall treatment effect to arteriosclerosis, treatment group is compared with matched group, and P<0.05, has comparability.

All above-mentioned this intellectual properties of primary enforcement, not setting restriction this new product of other forms of enforcement and/or new method.Those skilled in the art will utilize this important information, and foregoing is revised, to realize similar implementation status.But all modifications or transformation belong to the right of reservation based on new product of the present invention.

The above is only preferred embodiment of the present invention, and be not restriction the present invention being made to other form, any those skilled in the art may utilize the technology contents of above-mentioned announcement to be changed or be modified as the Equivalent embodiments of equivalent variations.But everyly do not depart from technical solution of the present invention content, any simple modification, equivalent variations and the remodeling done above embodiment according to technical spirit of the present invention, still belong to the protection domain of technical solution of the present invention.

Claims

1. treat the Chinese medicine composition of arteriosclerosis for one kind, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Fructus Mori 10-20 part, Flos Sophorae 10-20 part, Stamen Nelumbinis 10-20 part, Semen Cuscutae 10-20 part, Radix Aconiti Lateralis Preparata 10-20 part, Semen Sesami Nigrum 10-20 part, Rhizoma Anemones Altaicae 10-20 part, Flos Caraganae intermediae 10-20 part, Caulis Spatholobi 10-20 part, Oletum Trogopterori 10-20 part, Herba Pogostemonis 10-20 part, Radix Achyranthis Bidentatae 10-20 part, Colla Corii Asini 10-20 part, Fructus Choerospondiatis 10-20 part, Flos Ginseng 10-20 part, Flos Lilii viriduli 10-20 part, Folium Ginkgo 10-20 part, Flos Albiziae 10-20 part, Folium Linderae strychnifoliae 10-20 part, Herba Cistanches 10-20 part, Arillus Longan 10-20 part, Radix Salviae Miltiorrhizae 10-20 part, Radix Curcumae 10-20 part, fresh pears 10-20 part, Fructus Citri tangerinae 10-20 part, Fructus Citri Limoniae 10-20 part, Lac regis apis 10-20 part.

2. a kind of Chinese medicine composition for the treatment of arteriosclerosis according to claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: Fructus Mori 14-18 part, Flos Sophorae 14-18 part, Stamen Nelumbinis 14-18 part, Semen Cuscutae 14-18 part, Radix Aconiti Lateralis Preparata 14-18 part, Semen Sesami Nigrum 14-18 part, Rhizoma Anemones Altaicae 14-18 part, Flos Caraganae intermediae 14-18 part, Caulis Spatholobi 14-18 part, Oletum Trogopterori 14-18 part, Herba Pogostemonis 14-18 part, Radix Achyranthis Bidentatae 14-18 part, Colla Corii Asini 14-18 part, Fructus Choerospondiatis 14-18 part, Flos Ginseng 14-18 part, Flos Lilii viriduli 14-18 part, Folium Ginkgo 14-18 part, Flos Albiziae 14-18 part, Folium Linderae strychnifoliae 14-18 part, Herba Cistanches 14-18 part, Arillus Longan 14-18 part, Radix Salviae Miltiorrhizae 14-18 part, Radix Curcumae 14-18 part, fresh pears 14-18 part, Fructus Citri tangerinae 14-18 part, Fructus Citri Limoniae 14-18 part, Lac regis apis 14-18 part.

3. a kind of Chinese medicine composition for the treatment of arteriosclerosis according to claim 1, it is characterized in that, in described Chinese medicine preparation, the ratio of weight and number of various crude drug is: 16 parts, Fructus Mori, 16 parts, Flos Sophorae, Stamen Nelumbinis 16 parts, Semen Cuscutae 16 parts, Radix Aconiti Lateralis Preparata 16 parts, Semen Sesami Nigrum 16 parts, Rhizoma Anemones Altaicae 16 parts, Flos Caraganae intermediae 16 parts, Caulis Spatholobi 16 parts, Oletum Trogopterori 16 parts, Herba Pogostemonis 16 parts, Radix Achyranthis Bidentatae 16 parts, 16 parts, Colla Corii Asini, Fructus Choerospondiatis 16 parts, Flos Ginseng 16 parts, Flos Lilii viriduli 16 parts, Folium Ginkgo 16 parts, Flos Albiziae 16 parts, Folium Linderae strychnifoliae 16 parts, Herba Cistanches 16 parts, Arillus Longan 16 parts, Radix Salviae Miltiorrhizae 16 parts, Radix Curcumae 16 parts, fresh pears 16 parts, Fructus Citri tangerinae 16 parts, 16 parts, Fructus Citri Limoniae, Lac regis apis 16 parts.

4. a kind of preparation method for the treatment of the Chinese medicine composition of arteriosclerosis according to claim 1-3 any one, described Chinese medicine preparation dosage form is that the preparation method of capsule comprises:

Step c, by the merging of above-mentioned two kinds of filtrates, decompression recycling ethanol to be concentrated into liquor strength be 0.4g crude drug/mL, after sucking filtration, when the relative density of filtrate is about 20 DEG C 1.06; Above-mentioned filtrate is the macroporous adsorptive resins of 10L through volume, first uses deionized water or the distilled water eluting of 10 times of resin column volumes, then uses 95% ethanol elution of 5 times of resin column volumes, collects ethanol elution, removes solvent, obtains raw material medicated powder, incapsulate.

5. a kind of preparation method for the treatment of the Chinese medicine composition of arteriosclerosis according to claim 1-3 any one, described Chinese medicine preparation dosage form is that the preparation method of oral liquid comprises:

Step b, by surplus stock medicine, is placed in decoction pot, first time adds 3 times of water gagings, soak 3 hours, decoct 20-30 minute, leach decocting liquid, second time adds 2 times of water gagings again, decoct 20-30 minute, twice decocting liquid mixing adjusted and add extracting solution subharmonic again in step a all afterwards, being concentrated into liquor strength is 0.4g crude drug/mL oral liquid, filling device bottle, obtains oral liquid.

6. a kind of dosage form for the treatment of the Chinese medicine composition of arteriosclerosis according to claim 1-3 any one, pharmaceutical dosage form is: sugar coated tablet, film coated tablet, enteric coated tablet, oral liquid, granule, electuary, powder, sublimed preparation, solution, suppository, plaster, syrup.