CN104815171A

CN104815171A - Chinese herbal preparation for treating sputum-heat syndrome in acute exacerbation stage of chronic obstructive pulmonary disease

Info

Publication number: CN104815171A
Application number: CN201510180961.XA
Authority: CN
Inventors: 阮同德
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-04-12
Filing date: 2015-04-12
Publication date: 2015-08-05

Abstract

The invention discloses a Chinese herbal preparation for treating a sputum-heat syndrome in the acute exacerbation stage of the chronic obstructive pulmonary disease (COPD). COPD has the clinical common symptoms of throat coughing, slight sputum, chest distress, gasp worry and the like and belongs to 'cough', 'gasp syndrome', 'lung distension' and the like in Chinese medicine. The Chinese herbal preparation comprises the following traditional Chinese medicines: habenaria radiata, root of woolly lespedeza, root of Woods Greenstar, Arundina graminifolia, Stellaria yunnanensis, radix fici hirtae, bletilla formosana, all-grass of Yellowhairy oreocharis, herb of denseflower bulbophyllum, helwingia root and dragonhead herb, which are decocted in water into a decoction. Clinical tests show that the Chinese herbal preparation has the total effective rate of 96.6% and is worthy of clinical popularization and application.

Description

A kind of Chinese medicine preparation for the treatment of acute exacerbation of chronic obstructive pulmonary disease expectorant heat syndrome

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicine preparation for the treatment of acute exacerbation of chronic obstructive pulmonary disease expectorant heat syndrome.

Background technology

Chronic obstructive pulmonary disease (Chronic Obstructive Pulmonary Disease, COPD, be called for short chronic obstructive pulmonary disease) be respiratory system commonly encountered diseases, difficult treatment, distinguishing feature is developed into chronic progressive external, this disease is usually in repeatedly increasing the weight of trend, have a strong impact on life in patients, increase patient home's medical economy burden simultaneously.While western medicine routine treatment, also bring many clinical symptoms, as the abuse of antibacterials, misuse cause the appearance of various fastbacteria, and antibiotic of new generation can not develop in time, apply to clinical; Patient reduces the sensitivity of medicine, causes clinical efficacy to owe desirable, can not delay disease progression etc. preferably.Applicant is in clinical practice for many years, and this is sick to utilize treatment by Chinese herbs, and not only achieve good curative effect, and side effect is little, treatment cost is low.

Summary of the invention

The object of this invention is to provide a kind of Chinese medicine preparation for the treatment of acute exacerbation of chronic obstructive pulmonary disease expectorant heat syndrome.Chronic obstructive pulmonary disease (COPD) is clinical commonly coughs larynx, slightly expectorant, uncomfortable in chestly breathe heavily the symptoms such as anxious, belongs to the category such as the traditional Chinese medical science " cough ", " the syndrome of dyspnea ", " pulmonary distension ".This is much more sick by chronic lung pattern disease recurrent exerbation, protracted course of disease, causes the internal organs losss such as lung, spleen, kidney, thus causes lung qi distension, can not hold back and fall, and shows as swollen full, the feeling of distension and oppression of chest as stopped up, gas on cough with asthma, cough with copious phlegm etc.

The object of the invention is to be achieved through the following technical solutions, the Chinese medicine preparation of this treatment acute exacerbation of chronic obstructive pulmonary disease expectorant heat syndrome is made up of the Chinese medicine of following weight portion: Rhizoma Habenariae 15-25 part, Radix Lespedezae Tomentosae 10-20 part, Polyalthia nemoralis A. D C. 10-20 part, Herba Murdanniae Divergentis 15-25 part, Radix Stellariae Yunnanensis 20-30 part, Radix Fici Simplicissimae 30-40 part, Rhizoma Pleiones Yunnanensis 8-12 part, Herba Oreocharidis flavidae 15-25 part, Herba Bulbophylli Odoratissim 10-20 part, Radix Helwingiae 6-10 part, Herba Dracocephali Integrifolii 9-15 part.

Preferably, Rhizoma Habenariae 20 parts, Radix Lespedezae Tomentosae 15 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Murdanniae Divergentis 20 parts, Radix Stellariae Yunnanensis 25 parts, Radix Fici Simplicissimae 35 parts, Rhizoma Pleiones Yunnanensis 10 parts, Herba Oreocharidis flavidae 20 parts, Herba Bulbophylli Odoratissim 15 parts, 8 parts, Radix Helwingiae, Herba Dracocephali Integrifolii 12 parts.

Preparation method traditionally decocting becomes decoction.

Fang Zhong: Rhizoma Habenariae spleen invigorating tonify deficiency, stomach invigorating; Radix Lespedezae Tomentosae spleen invigorating tonify deficiency; Polyalthia nemoralis A. D C. invigorating spleen and reinforcing stomach, tonifying the kidney to consolidate the essence; Herba Murdanniae Divergentis tonifying speen and tonifying kidney, tonifying the lung and stopping cough; Radix Stellariae Yunnanensis spleen invigorating nourishing liver, invigorating kidney; Radix Fici Simplicissimae strengthening the spleen and tonifying the lung, week dampness removing; Rhizoma Pleiones Yunnanensis tonifying the lung is moisturized, relieving cough and resolving phlegm; Herba Oreocharidis flavidae nourishing the lung to arrest cough, QI invigorating; Herba Bulbophylli Odoratissim moistening the lung and resolving phlegm, promoting the circulation of QI to relieve pain; Radix Helwingiae antiasthmatic-antitussive, blood circulation promoting and blood stasis dispelling; Herba Dracocephali Integrifolii antitussive, relieving asthma, antiinflammatory.

Clinical data

1, physical data includes patient in for my institute in JIUYUE, 2010 to 2012 inpatient in year January, totally 60 examples, be divided into matched group and treatment group, through statistical procedures, two groups of sexes, age, the course of disease there are no significant difference (P > 0.05).

2, diagnostic criteria Western medicine diagnose standard: formulate according to diagnosis of chronic obstructive pulmonary disease, handling and prevention global strategy (GOLD) revised edition chronic obstructive pulmonary disease diagnosis and treatment guide (revised edition in 2013) in 2013.Tcm diagnosis standard: the diagnostic criteria of expectorant heat syndrome is formulated according to " new Chinese medicine guideline of clinical investigations " and " practical Chinese Internal Medicine " (second edition).Primary symptom: cough and expectoration, expectorant xanthin glues difficulty and to cough up and (or) uncomfortable in chest breathing heavily suppresses time disease: 1. generate heat not aversion to cold 2. vexed 3. thirst and liking drink 4. yellow urine 5. large dry stool 6. bitter taste xerostomia 7. red tongue with yellow fur.Primary symptom to hold concurrently in time disease 2, namely diagnosable.

3, Therapeutic Method matched group: adopt western medicine routine treatment: the COPD Acute Exacerbation Period Therapeutic Method process according to proposing in " chronic obstructive pulmonary disease diagnosis and treatment guide " (respirology branch of Chinese Medical Association chronic obstructive pulmonary disease group): control oxygen therapy: Persistent low flow oxygen therapy; Bronchodilator: theophylline: Slow-release Theopylline 0.2 gram, Q12h; Antibiotic: levofloxacin, 0.39, VD, Qd; Expectorant: mucosolvan (hydrochloric acid Australia cyclohexylamine alcohol), 30mg, Tid;

Treatment group: Chinese medicine associating western medicine routine treatment.Prescription: Rhizoma Habenariae 20g, Radix Lespedezae Tomentosae 15g, Polyalthia nemoralis A. D C. 15g, Herba Murdanniae Divergentis 20g, Radix Stellariae Yunnanensis 25g, Radix Fici Simplicissimae 35g, Rhizoma Pleiones Yunnanensis 10g, Herba Oreocharidis flavidae 20g, Herba Bulbophylli Odoratissim 15g, Radix Helwingiae 8g, Herba Dracocephali Integrifolii 12g, every agent 500ml that adds water decocts to 300ml, take at twice, every day 1 dose.The course for the treatment of: 10 days be a course for the treatment of, carry out therapeutic evaluation at the end of the course for the treatment of.Viewing duration, as because of aggravation person, performs by " chronic obstructive pulmonary disease diagnosis and treatment guide ".

4, criterion of therapeutical effect is with reference to " new Chinese medicine guideline of clinical investigations ".(Zheng Xiao edits. new Chinese medicine guideline of clinical investigations. and Beijing: China Medical Science Press, 2002) clinic control: clinical symptoms, sign disappear or substantially disappear, and syndrome integral reduces >=95%.Effective: clinical symptoms, sign are obviously improved, syndrome integral reduces >=70%.Effective: clinical symptoms, sign all take a favorable turn, syndrome integral reduces >=30%.Invalid: clinical symptoms, sign are not improved, even increase the weight of, syndrome integral reduces less than 30%

5, therapeutic outcome can know the treatment through 10 days from table, treatment group total effective rate is 96.67%, matched group total effective rate is 66.67%, its treatment curative effect for the treatment of group is compared with matched group, there is significant difference (P < 0.01), illustrate that the therapeutic effect for the treatment of group is obviously better than matched group.

Group	n	Clinic control	Effective	Effectively	Invalid	Total effective rate
							Treatment group	30	3	15	11	1	96.67％
Matched group	30	2	9	14	5	66.67％

Haemanalysis there was no significant difference before two groups of patient treatments, after the clinical observation of 10 days, leukocyte, neutrophilic granulocyte percentage ratio decline to some extent, two groups without significant difference (P > 0.05), equal Non Apparent Abnormality before and after hematochrome, anti-platelet therapy, stool routine examination, urinalysis and hepatic and renal function no significant difference before and after treatment.Point out Chinese medicine preparation of the present invention and oral theophylline slow releasing tablet, mucosolvan, quiet levofloxacin has no obvious toxic and side effects.

Detailed description of the invention

Embodiment one: take Rhizoma Habenariae 20g, Radix Lespedezae Tomentosae 15g, Polyalthia nemoralis A. D C. 15g, Herba Murdanniae Divergentis 20g, Radix Stellariae Yunnanensis 25g, Radix Fici Simplicissimae 35g, Rhizoma Pleiones Yunnanensis 10g, Herba Oreocharidis flavidae 20g, Herba Bulbophylli Odoratissim 15g, Radix Helwingiae 8g, Herba Dracocephali Integrifolii 12g, every agent 500ml that adds water decocts to 300ml.

Embodiment two: take Rhizoma Habenariae 25g, Radix Lespedezae Tomentosae 10g, Polyalthia nemoralis A. D C. 20g, Herba Murdanniae Divergentis 15g, Radix Stellariae Yunnanensis 30g, Radix Fici Simplicissimae 30g, Rhizoma Pleiones Yunnanensis 12g, Herba Oreocharidis flavidae 15g, Herba Bulbophylli Odoratissim 20g, Radix Helwingiae 6g, Herba Dracocephali Integrifolii 15g, every agent 500ml that adds water decocts to 300ml.

Embodiment three: take Rhizoma Habenariae 15g, Radix Lespedezae Tomentosae 20g, Polyalthia nemoralis A. D C. 10g, Herba Murdanniae Divergentis 25g, Radix Stellariae Yunnanensis 20g, Radix Fici Simplicissimae 40g, Rhizoma Pleiones Yunnanensis 8g, Herba Oreocharidis flavidae 25g, Herba Bulbophylli Odoratissim 10g, Radix Helwingiae 10g, Herba Dracocephali Integrifolii 9g, every agent 500ml that adds water decocts to 300ml.

Claims

1. treat a Chinese medicine preparation for acute exacerbation of chronic obstructive pulmonary disease expectorant heat syndrome, it is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Rhizoma Habenariae 15-25 part, Radix Lespedezae Tomentosae 10-20 part, Polyalthia nemoralis A. D C. 10-20 part, Herba Murdanniae Divergentis 15-25 part, Radix Stellariae Yunnanensis 20-30 part, Radix Fici Simplicissimae 30-40 part, Rhizoma Pleiones Yunnanensis 8-12 part, Herba Oreocharidis flavidae 15-25 part, Herba Bulbophylli Odoratissim 10-20 part, Radix Helwingiae 6-10 part, Herba Dracocephali Integrifolii 9-15 part.

2. a kind of Chinese medicine preparation for the treatment of acute exacerbation of chronic obstructive pulmonary disease expectorant heat syndrome as claimed in claim 1, is characterized in that this Chinese medicine preparation is made up of the Chinese medicine of following weight portion: Rhizoma Habenariae 20 parts, Radix Lespedezae Tomentosae 15 parts, Polyalthia nemoralis A. D C. 15 parts, Herba Murdanniae Divergentis 20 parts, Radix Stellariae Yunnanensis 25 parts, Radix Fici Simplicissimae 35 parts, Rhizoma Pleiones Yunnanensis 10 parts, Herba Oreocharidis flavidae 20 parts, Herba Bulbophylli Odoratissim 15 parts, 8 parts, Radix Helwingiae, Herba Dracocephali Integrifolii 12 parts.