CN104784472A - Traditional Chinese medicine composition for decreasing blood sugar to treat diabetes - Google Patents
Traditional Chinese medicine composition for decreasing blood sugar to treat diabetes Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for decreasing blood sugar to treat diabetes. The composition comprises 10 parts of each of dried radix rehmanniae, Chinese yam, mulberry, trichosanthes root, polygonatum rhizome, radix astragali, and gypsum; 5 parts of each of matrimony vine, ophiopogon japonicas, kudzuvine root, fructus corni, and scorch-fried atractylodes, and 3 parts of each of anemarrhena and cape jasmine. A use and preparation method of the traditional Chinese medicine composition comprises: processing and drying the materials above; mixing and pulverizing the materials; sieving the resultant coarse powder through a 100 mesh sieve to obtain fine powder; weighing and packaging the powder; putting every 0.3g of the fine powder into a No.1 capsule; and compacting and sealing the capsule.
Description
Technical field
The invention belongs to tcm field, relate to the Chinese medicine composition of potion blood sugar lowering treatment diabetes.
Background technology
Diabetes are a kind of common endocrine metabolism diseases, it is the disease of the third-largest serious threat human health after tumor, vascular lesion, there is the feature of high fatality rate, high disability rate and high health care costs, become our times various countries common faced by public health problem.Though for many years through all multi-expert effort, also fail to capture this difficult problem.Usually could only be expectant treatment, the misery that patient is incomparable, serious along with the state of an illness, multiple complications be wreaked havoc at health, makes the complexion changed of much people's what is said or talked about, and In the view of them, can maintain is just very lucky already, can only think Arabian Nights if cure!
At present, the diabetics of developed country more than 50% all accepts insulinize, and this ratio domestic is 11.1%.The result display of UKPDS research, diabetics can first from single oral antidiabetic drug treatment, then the oral antidiabetic drug merging other type of application is needed gradually, along with going down further and the deficiency of insulin secretion of islet beta cell function, reach the desirable target controlling blood glucose, most of needs of patients starts insulinize.In this regard, the multiple antidiabetic drug of doctor trained in Western medicine remains the of short duration method of curing the symptoms, not the disease, and draws the conclusion that doctor trained in Western medicine " controls for diabetes only, can not effect a radical cure " thus.
Diabetes are called " diabetes " by the traditional Chinese medical science, namely we often say more than three: polydipsia, polyphagia, polyuria." diabetes " this name of disease is just described in China's medical book Plain Questions of Huangdi's Internal Classic the earliest and Miraculous Pivot.It is due to deficiency-weakness of spleen-QI that "Nei Jing" has pointed out the truth diabetes, sinking of QI of middle-JIAO, lets out and form under causing sweet juice.Qing Dynasty Lin Peiqin also cloud in " class disease controls sanction " three disappears: " the not smelly anti-sweet person of urine, under its temper, de-disease is the heaviest." and then, the Republic of China well-known doctor Xie Liheng cloud again in " Chinese medicine voluminous dictionary " quenches one's thirst treatment 17: " the urine person that does sweet gas, de-under this temper, for disease is the heaviest." for the treatment of diabetes; the prescription be handed down ancient times is a lot; such as: dabuyin pill, LIUWEI DIHUANG WAN, Ginseng Baihu Decoction, SHENLING BAISHU SAN, XIAOYAO POWDER, dihuang drink, Taoren Chengqi Tang, BUYANG HUANWU TANG, YUQUAN WAN etc. are numerous; because formulation principle is very unclear; therefore have quality during administering therapeutic result, be difficult to promote.The dialectical mechanism in traditional Chinese medical science Inner source that we produce according to diabetes, from the angle of " holding up spleen invigorating middle warmer ", selects reasonable medical material, and configuration diet therapy formulation, effectively can reduce blood glucose, reaches the object for the treatment of diabetes.
Technology contents
The object of this invention is to provide the Chinese medicine composition of a kind of blood sugar lowering treatment diabetes, said composition selects natural Chinese medicine to treat diabetes as drug material, has good therapeutic effect.
The Chinese medicine composition that the present invention treats diabetes is made up of following each Chinese medicine:
The Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Mori, Radix Trichosanthis, Rhizoma Polygonati, the Radix Astragali, Gypsum Fibrosum, Fructus Lycii, Radix Ophiopogonis, Radix Puerariae, taro meat, Rhizoma Atractylodis Macrocephalae preparata, the Rhizoma Anemarrhenae, SHANZHIZI.
The weight proportion of the Chinese medicine composition various Chinese medicinal components used of blood sugar lowering treatment diabetes of the present invention is:
The Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Mori, Radix Trichosanthis, Rhizoma Polygonati, the Radix Astragali, each 10 parts of Gypsum Fibrosum; Fructus Lycii, Radix Ophiopogonis, Radix Puerariae, taro meat, each 5 parts of Rhizoma Atractylodis Macrocephalae preparata; Each 3 parts of the Rhizoma Anemarrhenae, SHANZHIZI.
The preparation and application of the Chinese medicine composition of blood sugar lowering treatment diabetes of the present invention is:
First carry out co-grinding after being dried by the 14 kinds of Chinese medicine processing selected, obtain fine powder after gained coarse powder is crossed 100 mesh sieves, subpackage of weighing, every part of 0.3g, load No. 1 capsule, compacting seals.Oral, one time 3 ~ 5,3 times on the one.15 days course for the treatment of.
The Chinese medicine composition of blood sugar lowering treatment diabetes of the present invention, takes period and answers static(al) to accomplish, can not work hard, make sure to keep in mind room wish.Diet shrimp Eriocheir sinensis and raw and cold stick-slip wine cheese etc. damage the product of taste.
The Chinese medicine composition of blood sugar lowering treatment diabetes of the present invention, has clear and definite Chinese and western medicine medication theories integration.Saying of doctor trained in Western medicine, thinks that diabetes are a kind of due to islet function imbalance, hypoinsulinism and the endocrine and metabolic disorders disease that causes.This only sees the pathogenetic local phenomenon of glycosuria.The morbidity root that the traditional Chinese medical science has then known diabetes completely clearly is because gastric heat knot is poly-, deficiency-weakness of spleen-QI, and sinking of QI of middle-JIAO, lets out under causing sweet juice and form, and treatment needs nourishing kidney spleen invigorating lung moistening to disappear gastric heat.The function one of pancreas is that secretion pancreatic juice helps digestion, and two is excreting insulins, regulates the metabolism of human body sugar.The so-called endocrine of doctor trained in Western medicine, the body fluid category of the subordination traditional Chinese medical science, by taste, institute is biochemical.Say it according to theory of Chinese medical science, human five internal organs's six internal organs, be all subject to the nutrition of gastric qi.So whether normal the function of human five internal organs's six internal organs is, depend on the nutrition supply of the taste day after tomorrow.Depend on again the prosperity and decline of gastric qi.Therefore " Huatuo's Zhongzang classic " is said: " gastric qi is strengthened, then the vital organs of the human body are all strong also ".So-called " gastric qi ", i.e., after the diet entrance of people, cooperatively interact through being received of stomach, ripe rotten function and the transporting of spleen, raw cleaning function, share out the work and help one another, essence of water and grain material is flowed to each internal organs inside and outside human body continually, become the nutrition source of human body.This of taste cooperatively interacts, and namely the function of sharing out the work and help one another is " gastric qi ".Only have the function of taste normal, gastric qi is vigorous, and internal organs could be made vigorous, and function is normal, and coordinate, Each performs its own functions, and each doing his best, and ground maintains the vital movement of human body and the body of health jointly.
If because gastric qi is weak, sinking of QI of middle-JIAO, transporting, the raw cleaning function of spleen go down, lowly even lose, and can not normally be transferred out by nutrient substance, therefore the vital organs of the human body lose normal nutrition supply.The splenopathy adds up the five internal organs, and pancreas is dirty as the pair of spleen, first round its calamity, and pancreatic function is gradually weak, function goes down thereupon, lowly, imbalance, can not normal secretions insulin, thus cause insulin relatively or definitely not enough, just cause endocrine and metabolic disorders disease.Therefore, the source of effecting a permanent cure of diabetes, is " nourishing kidney spleen invigorating lung moistening disappear gastric heat ", thus recovers " gastric qi ".
The Chinese medicine composition of blood sugar lowering of the present invention treatment diabetes, with reference to plurality of medical pharmacopeia, in line with the principle of " nourishing kidney spleen invigorating lung moistening disappear gastric heat ", is aided with the optimization of clinical application for many years simultaneously, overcomes the problem of taboo combination, select medicine.
The Chinese medicine composition of blood sugar lowering treatment diabetes of the present invention, as follows by prescription solution: Rhizoma Dioscoreae, taro meat, the Radix Astragali, Fructus Lycii, Fructus Mori nourishing the stomach nourishing kidney qi blood; Radix Ophiopogonis lung moistening; Radix Trichosanthis, the Radix Rehmanniae, the Rhizoma Anemarrhenae, Radix Puerariae, SHANZHIZI, Gypsum Fibrosum clearing away heat and cooling blood, promoting the production of body fluid to quench thirst.
The Rhizoma Anemarrhenae, bitter, sweet, cold.Return lung, stomach, kidney channel.Gunpowder under genus heat clearing away, cures mainly: epidemic febrile disease, high hot excessive thirst, cough and asthma, cough caused by dryness, constipation, osteopyrexia and fever, restlessness of asrhenia type and insomnia, stranguria with turbid discharge of quenching one's thirst.Impact on blood glucose: Rhizoma Anemarrhenae water logging extract, can reduce the blood sugar level of normal rabbit, particularly more remarkable to the effect of four oxygen close pyridine Diabetic Rabbits.Extract 0.5 ~ 1g/kg lumbar injection of Baihu Jia Renshen Tang (Rhizoma Anemarrhenae, Radix Ginseng, Radix Glycyrrhizae), also has tissue of experimental diabetic mice and falls hypoglycemic effect, 6 hours decline 120mg% after administration.To normal rat, the Rhizoma Anemarrhenae can not promote the oxidation of glucose, though can promote that diaphragm, fatty tissue are to the picked-up of glucose, glycogen content in diaphragm is slightly increased, and liver glycogen content decreases.To the mice of experimental (alloxan) diabetes, lumbar injection Rhizoma Anemarrhenae aqueous extract 0.15g/kg, 5 hours blood glucose decline 200mg%.
The Radix Astragali, sweet in the mouth, slightly warm in nature.Return lung, spleen, liver, kidney channel.The Radix Astragali has effect that benefiting QI for strengthening the superficies, arresting sweating are admittedly de-, hold in the palm skin ulcer granulation promoting, inducing diuresis to remove edema.Be used for the treatment of the deficiency of vital energy weak, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, metrorrhagia of having blood in stool, exterior deficiency spontaneous perspiration, interior-heat is quenched one's thirst, chronic nephritis, diabetes etc.For invigorating the spleen and replenishing QI aspect.The disease such as unable as tired in weakness of the spleen and stomach, inappetence, anorexia and loose stool, limb, often uses together with Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae, Rhizoma Dioscoreae; As collapse of QI, visceroptosis, as proctoptosis, gastroptosis etc., be often equal to use with Radix Codonopsis, Rhizoma Cimicifugae, Radix Bupleuri, side is as BUZHONG YIQI TANG.The Radix Astragali and Radix Ginseng all belong to QI invigorating good medicine, but Radix Ginseng biases toward strongly invigorating primordial QI.Radix Astragali tool and mending and oiliness feature, and if Radix Ginseng, the tonic compatibility then better effects if such as Radix Codonopsis.
We Chinese medicine composition entrust Hengyang Medical College to carry out the experiment of non-clinical pharmacological animal, experimental program and result as follows:
1, experiment material
Wstar rat, male, body constitution 180 ~ 230g, is provided by Medical School of Zhengzhou University animal Culture Center.Reference agent is alloxan, is SIGMA Products, and lot number B-10543, concentration is 50mg/ml.
2, experimental technique
After 20 Wistar Rat Fast 18h, lumbar injection alloxan 200mg/kg, 48h ophthalmic corner of the eyes venous plexus is taken a blood sample, serum blood glucose is surveyed with 7850 automatic biochemistry analyzers, except 2 death, 18 blood glucose values of Yuing are 20.7 ~ 45.6mmol/L, are into mould animal (blood glucose value >=15.45mmol/L).By blood glucose value height, divide equally in matched group and treatment group.Treatment group every day 2 times, the morning 8:00, afternoon, 2:00 gastric infusion, weighed weekly 1 time.Matched group is every only each to distilled water 10ml, and treatment group is often only each gives 2.0g crude drug/kg.Successive administration is fasting feedwater 16h after 2 weeks, and ophthalmic corner of the eyes venous plexus is taken a blood sample, and surveys serum blood glucose with 7850 automatic biochemistry analyzers.Result of the test adopts corresponding statistical method process, mortality rate x between two groups
2inspection, between two groups, mean significance compares and checks with t.
3, experimental result
Administration the 1st week, contrast and treatment group have no significant difference (table 1), all have animal dead (each 2) 1 weekend.Within 2nd week, control animals occurs that diet reduces, unable few dynamic, develops into stupor gradually, 4 death.The situation for the treatment of group animal is better. and amount of drinking water increases by 1 times, only has 1 animal to occur unable symptom, and within the 3rd week, matched group is all dead, and treatment group has 2 death in 3 weeks, through x
2inspection, P < 0.05.Alloxan diabetes rats, after this medicament composing prescription treats 2 weeks, compares with before self administration, and elevated blood glucose levels has remarkable reduction, and P < 0.01 compares P < 0.01 with matched group.In table 2.
Table 1 alloxan Oral Administration in Rats Chinese medicine composition curative effect of the present invention
| Group | Number of animals | Body weight | 48h blood glucose |
| Matched group | 9 | 166±13.3 | 44.1±6.9 |
| Treatment group | 9 | 175±15.6 | 38.3±5.2 |
Table 2 alloxan Oral Administration in Rats Chinese medicine composition of the present invention 2 weeks curative effects
Leading reference: [1] Song great Song, Kong Shunxian. diabetes treatment through spleen knows from experience [J]. Chinese Medicine journal, 2003,18 (10): 611; [2] Zhao Cuifang, Guan Song, Liu's copper bloom. from the importance and functions [J] of recur common cold tcm diagnosis and treatment diabetes. Beijing University of Chinese Medicine's journal, 2009,16 (3): 38; [3] Zhong Juan, Wei Lianbo, Longhai City's ripple. the Radix Astragali and active ingredient treatment diabetic nephropathy Recent Advances in Mechanism [J] thereof. packet header medical college journal, 2011,27 (5): 101; [4] Piao Chunmei. the Radix Astragali is to the pharmacology study mechanism recent developments [J] of diabetes. Yunnan Chinese medicine magazine, 2005,26 (2): 54; [5] Li Cunliang. Astragalus in Treating diabetes mechanism of action and clinical application research progress [J]. contemporary Chinese medicinal application, 2011,5 (24): 124; [6] plumcot English, Zhang Songlin. the prepared slices of Chinese crude drugs Radix Astragali is on the impact [J] of type 2 diabetes mellitus insulin secretion function and insulin resistant. Chinese medicine, 2012,2 (14): 85; [7] Lu Shenghua, Sun Hongwei, Wang Juying, etc. Rhizoma anemarrhenae polysaccharide blood sugar reducing function and study mechanism [J] thereof. Chinese biochemical drug magazine, 2003,24 (2): 81; [8] Huang Fang, Xu Lihua, Guo Jianming, Chen Ting, etc. the blood sugar reducing function [J] of Rhizoma Anemarrhenae extract. Chinese biochemical drug magazine, 2005,26 (6): 332; [9] Liang Lei, limit Po Lam, Wang Hongjie. Chinese medicine blood-sugar decreasing active Recent Research [J]. Chinese experimental pharmacology of Chinese medical formulae magazine, 2010,17 (7): 227.
Clinical efficacy
1. sample information
Sample is clinical diabetes patient, effective 55 examples.Man 39 example wherein, female 16 example, age reckling 37 years old, the oldest person 66 years old.
2. Therapeutic Method
Oral, one time 3 ~ 5,3 times on the one.15 days course for the treatment of.
3. therapeutic outcome
Use the various diabetes of this traditional Chinese medicine composition for treating over several years, result shows this Chinese medicine composition for diabetics, evident in efficacy, clinical symptoms can be eliminated fast, take medicine 1 ~ 2 course for the treatment of, Western medicine and dependence product can be removed, do not need dietary restriction amount completely from start to finish.According to state of an illness situation, take medicine 2 ~ 5 courses for the treatment of, clinical symptoms can alleviate or disappear old substantially, improves the state of an illness.
4. model case
1, patient Liu so-and-so, man, 63 years old.Diabetes medical history 3 years, found xerostomia before 3 years, skin pruritus, and health check-up finds that fasting glucose is elevated to 9.5mmol/L, glycolated hemoglobin 7.3%, and post-prandial glycemia 9.9mmol/L, BMI:24, make a definite diagnosis diabetes.
Originally hospitalize is gone, give metformin 0.5bid, NovoNorm 1mgtid, glycemic control is not very desirable, control fasting glucose 7.4mmol/L after three months, post-prandial glycemia 13.5mmol/L, glycolated hemoglobin 8.6%, patient does not accept insulinize always, until check that discovery optical fundus blood capillary finds to bleed profusely a little the year before, affect one's power of vision, laser therapy is carried out in decision, patient this just accept insulinize, so therapeutic scheme changes into, Lantus is fixing every night sprays once each 10 units, check after such one month, fasting glucose 6.6mmol/L, post-prandial glycemia 11.4mmol/L.Postprandial glucose control is still bad.After use Chinese medicine composition Regimen Chemotherapy of the present invention instead, adhere to every day 3 times, each 5 capsules.Such treatment is had a blood test after one month sugar again, on an empty stomach: 6.8mmol/L, after the meal: 7.8mmol/L.Saccharifying and blood glucose is again looked into after three months, on an empty stomach: 6.8mmol/L, after the meal: 7.8mmol/L, saccharifying: 6.5%.Glycemic control is good, and completely not by food effect.After adhering to taking two first quarter moons, inspection in hospital, blood sugar level is normal, has recovered completely.Follow up a case by regular visits to so far, do not recur.
2, patient king so-and-so, man, 53 years old.In May, 2007, Mr. Wang occurs that build is become thin, and normal sense is tired; Frequent micturition, excessive thirst, amount of drinking water increases, and appetite increases, and within 2 ~ 3 hours after the meal, namely feel hungry, sexual function sharply declines.Remove examination in hospital, blood pressure: 140/90mmHg, two pulmonary respiration sound is clear, does not hear and dry, moist rales, and border of cardiac dullness is without expansion, and heart rate 88 beats/min, hear sounds is low blunt, and the rhythm of the heart is neat, does not hear and noise.Touch too late under liver, spleen rib, two lower limb are without edema.Fasting glucose: 23.6mmol/L (normal value 3.9-6.1mmol/L), after the meal 2 hours blood glucoses: 29.7mmol/L (normal value 3.9-7.8mmol/L).Glucose in urine (+++) (normal glucose in urine is negative).Be diagnosed as diabetes.Hospitalization 3 months, effect is not desirable, and my one of coming across cures patient, informs that it is sought medical advice to here.Use 2 courses for the treatment of of our medicine, more than three, symptom is all eliminated, and treat 4 courses for the treatment of, health is got well substantially, vision, and libido function also recovers normal substantially, therapeutic process without insulin, also without Western medicine.Complete in Chinese medicine, finally cure.
Specific embodiment
By the Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Mori, Radix Trichosanthis, Rhizoma Polygonati, the Radix Astragali, each 100 grams of Gypsum Fibrosum; Fructus Lycii, Radix Ophiopogonis, Radix Puerariae, taro meat, each 50 grams of Rhizoma Atractylodis Macrocephalae preparata; Each 30 grams of the Rhizoma Anemarrhenae, SHANZHIZI.Concoct respectively after drying and carry out co-grinding, obtain fine powder after gained coarse powder is crossed 100 mesh sieves, subpackage of weighing, every part of 0.3g, load No. 1 capsule, compacting seals.
Oral, one time 3 ~ 5,3 times on the one.15 days course for the treatment of.
Chinese medicine composition of the present invention, takes period and answers static(al) to accomplish, can not work hard, make sure to keep in mind room wish.Diet shrimp Eriocheir sinensis and raw and cold stick-slip wine cheese etc. damage the product of taste.
Claims (1)
1. blood sugar lowering treatment diabetes a Chinese medicine composition, it is characterized in that by following Chinese medicine by weight ratio form:
The Radix Rehmanniae, Rhizoma Dioscoreae, Fructus Mori, Radix Trichosanthis, Rhizoma Polygonati, the Radix Astragali, each 10 parts of Gypsum Fibrosum; Fructus Lycii, Radix Ophiopogonis, Radix Puerariae, taro meat, each 5 parts of Rhizoma Atractylodis Macrocephalae preparata; Each 3 parts of the Rhizoma Anemarrhenae, SHANZHIZI.
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