CN104689369A - Degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for human body and application thereof - Google Patents
Degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for human body and application thereof Download PDFInfo
- Publication number
- CN104689369A CN104689369A CN201510112259.XA CN201510112259A CN104689369A CN 104689369 A CN104689369 A CN 104689369A CN 201510112259 A CN201510112259 A CN 201510112259A CN 104689369 A CN104689369 A CN 104689369A
- Authority
- CN
- China
- Prior art keywords
- kirsite
- human body
- degradable
- strength
- corrosion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L17/00—Materials for surgical sutures or for ligaturing blood vessels ; Materials for prostheses or catheters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/02—Inorganic materials
- A61L27/04—Metals or alloys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/02—Inorganic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
-
- C—CHEMISTRY; METALLURGY
- C22—METALLURGY; FERROUS OR NON-FERROUS ALLOYS; TREATMENT OF ALLOYS OR NON-FERROUS METALS
- C22C—ALLOYS
- C22C18/00—Alloys based on zinc
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Vascular Medicine (AREA)
- Surgery (AREA)
- Dermatology (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Materials Engineering (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Mechanical Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Abstract
The invention provides a degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for a human body and application thereof and relates to the field of medical implant materials. The corrosion-resistant high-toughness Zn-Fe zinc alloy provided by the invention is aimed at overcoming the defects in the prior art and has the advantages that the cost of adding materials is low, the strength is high, the plasticity is good, the degradation rate is controllable, and meanwhile, the Zn-Fe zinc alloy can be degraded by human bodies. The zinc alloy contains a Zn element and a Fe element, wherein the mass percent of Zn element is 90-99.998%, and the mass percent of Fe element is 0.002-10%. According to the zinc alloy provided by the invention, the cost of the added materials is low, degradation products of all ingredients of a prepared alloy material can be degraded through human body metabolism, the corrosion resistance is far higher than that of a magnesium alloy, the degradation rate is greatly lowered, a longer-time mechanical support can be provided, and the strength and toughness of the alloy material are good.
Description
Technical field
The present invention relates to the degradable corrosion-proof and high-strength of a kind of human body tough Zn-Fe system kirsite, belong to medical embedded material technical field.
Background technology
Zinc ion is the nutrient of needed by human, participates in the metabolic activity that human body is a lot.U.S. clinical creative design (ACI) recommends human body must take in the zinc of 2.5 to 6.4 milligrams every day, and adult takes in about 300 milligrams of zinc every day just may have certain toxic reaction.The zinc of one piece of zinc-base degradable bone peg release every day is approximately 0.2 ~ 0.3 milligram, even if these zinc ioies are all discharged in blood vessel, also well below the intake of needed by human.That is, the zinc ion of zinc-base degradable orthopaedics implantation instrument degraded release can not cause general toxicity.Research also finds, the transport of zinc ion in tissue is very fast, therefore there will not be zinc enrichment, cytotoxicity or necrosis near zinc-base degradable orthopaedics implantation instrument.
The function of zinc ion in human body is a lot, and extremely important to human body, a wherein very important function promotes bone growth exactly.Research worker finds the aminoacyl tRNA synthetase that can activate due to zinc ion in osteoblast, and effectively can suppress differentiation and the growth of osteoclast, therefore the existence of zinc ion not only facilitates the increase of bone calcium salt content, also help the raising of bone collagen content, this illustrates that zinc ion has directly short osteogenesis function.In addition, research also finds that zinc ion promotes the combination of cartilage oligomeric matrix protein and collagen, is the catalytic elements of cartilage growth and regeneration.
Traditional intravascular stent generally adopts nondegradable metal to make, and its shortcoming is metal non-degradable, cannot takes out, and is trapped in Ink vessel transfusing and easily causes advanced thrombus.A large amount of clinical cases confirms patient to implant this kind of support, and after 1 ~ 5 year, thrombosis rate is up to 3% ~ 9%, and after thrombosis, mortality rate is up to 30%.Nail and hone lamella are conventional fixing fracture and the medical implantation instrument of ligament injury, and traditional nail and hone lamella cannot be taken out by nondegradable metal, must carry out second operation, bring great wound to patient.Meanwhile, traditional metal materials intensity is too high, easily brings stress shielding, causes injured osseous tissue to be difficult to regeneration and healing.
In human body, degradable medical material is becoming the emphasis of research and development, and wherein degradable high polymer material, pure iron and ferrous alloy, pure magnesium and magnesium based alloys are the most deep materials of research in recent years.Degradable high polymer material intensity is too low, in Clinical practice process, often fracture accident can occur, and clinical applicability receives very big restriction.The intensity of pure iron and ferrous alloy and toughness are far above macromolecular material, but the degradation speed of ferrum is too slow, and the degradable time may reach the several years.More seriously, the rust shape mass volume generated in ferrum degradation process expands several times, and has obvious migration trend.The catabolite of pure magnesium and magnesium based alloys is nontoxic, degradable, but the non-constant of its corrosion resistance, will soon be degraded in human body, the enough mechanical support time cannot be provided.
Pure zinc and alloy thereof are also degradable materials under a kind of human body environment, but be applied in medical material aspect and still have that mechanical strength is low, the uncontrollable shortcoming of degradation rate, all improve mechanical property and regulation and control degradation rate by adding other material to reach to it at present, Ce, Mg, Cu, Ca is added in zinc disclosed in application number 201310756776.1, but zinc alloy material plasticity prepared by this application is lower, and also do not find the adding material of cheap ferrum as zinc at present, use as bio-medical material.
Summary of the invention
The object of the invention is the deficiency existed for existing medical embedded material, provide a kind of adding material cost low, intensity is high, plasticity good, and degradation rate is controlled, the Zn-Fe system kirsite simultaneously can degraded by human body and application thereof.
The invention provides the degradable corrosion-proof and high-strength of a kind of human body tough Zn-Fe system kirsite, described kirsite comprises Zn and Fe element; Wherein the mass percentage of Zn element is: the mass percentage of 90 ~ 99.998%, Fe element is: 0.002 ~ 10%.
Based on the composition of above alloy material, in order to optimize mechanical property and biological corrosion performance, we to the mass percentage that zinc alloy material is optimized for Zn element in kirsite are: the mass percent of 92 ~ 99.995%, Fe element is 0.005 ~ 8%.
More preferably, also comprise trace element in described kirsite, described trace element is at least one in Mg, Ca, Sr, Li, Si, Mn and rare earth element, and the mass ratio of described trace element and Zn element is 0 ~ 0.056:1.
Based on the composition of above alloy material, in order to optimize mechanical property and biological corrosion performance, we are optimized for by alloy material further, and the mass ratio of described kirsite medium trace element and Zn element is 0 ~ 0.023:1.
The degradable corrosion-proof and high-strength of human body prepared by foregoing invention tough Zn-Fe system kirsite, uses the method for this area routine to be prepared into degradable medical implant.
Therefore, the present invention also provides the degradable corrosion-proof and high-strength of a kind of human body tough Zn-Fe system kirsite preparing the application in degradable medical apparatus material.
Preferably, described degradable medical apparatus is implant frame, orthopaedics implantation instrument, gear division implantation instrument, operation suture thread or anastomat.Wherein implant frame comprises intravascular stent, trachea bracket, urethra rack, esophageal stents appear, intestinal stent or biliary tract rack; Orthopaedics implantation instrument comprises fixed screw, fixing rivet, hone lamella, bone cover, intramedullary needle or bone tissue restoration support; Anastomat comprises bowel anastomosis device, blood vessel anastomat or neural anastomosis device.
The present invention has following beneficial effect:
1, adding material is with low cost, and each ingredient degradation product of alloy material of preparation can be degraded by body metabolism;
2, corrosion resistance is far above magnesium alloy, and degradation rate is controlled;
3, alloy material intensity and good toughness.Ferrum element has the dual function of solution strengthening and precipitation strength at a room temperature and a high temperature, can with Zn formed plurality of stable intermetallic compound, play invigoration effect, and have crystal grain thinning, improve the effect of plasticity, improve alloy material intensity and toughness.
Accompanying drawing explanation
Fig. 1 is that alloy of the present invention is degraded microstructure schematic diagram in animal body.
Detailed description of the invention
Below in conjunction with specific embodiment, the present invention will be further described.
Due to the difference of biotic environment and functional requirement, the different requirement of degradable implantation instrument to degradation speed is different.Zinc corrosion potential be-0.76V, the corrosion potential of ferrum is-0.44V, therefore ferrum adds in zinc as alloying element and can produce two kinds of reverse effects simultaneously, and the first effect is that ferrum element is solidly soluted in matrix zinc, and the corrosion potential of zinc reduces, corrosion resistance strengthens, degradation speed reduces; The second effect is that ferrum element and zinc element generate granular compound, forms micro cell, corrosion resistance declines, degradation speed raises with matrix zinc.By regulating the content of ferrum, the degradation speed controlling kirsite can be reached and make it be suitable for the requirement of medical embedded material.
Embodiment 1
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe system kirsite, its elementary composition and mass percent is: Zn 90%, Fe 10%.
Embodiment 2
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe system kirsite, its elementary composition and mass percent is: Zn 99.998%, Fe 0.002%.
Embodiment 3
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe system kirsite, its elementary composition and mass percent is: Zn 99.975%, Fe 0.01%, Mg0.015%.
Embodiment 4
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe system kirsite, its elementary composition and mass percent is: Zn 98%, Fe 1%, Mg 1%
Embodiment 5
The degradable corrosion-proof and high-strength of a kind of human body of the present invention tough Zn-Fe system kirsite, its elementary composition and mass percent is: Zn 97.5%, Fe 2%, Ce 0.5%.
Embodiment 6
With the Zn-Fe system kirsite that elementary composition use this area conventional method in embodiment 1 ~ 5 is obtained, carry out simulated body fluid soak test, test Zn-Fe system kirsite degradation rate experimental results is as table one:
Table one
The present embodiment is studied the external degradation mechanism of zinc-base Zn-Fe system alloy and degradation property according to ASTM-G31-72 standard method of test, the simulated body fluid simulated body fluid environment of 37 degrees Celsius, find that the degradation speed of Zn-Fe system kirsite is slow and controlled in this environment.
Embodiment 7
Carry out tensile strength test with the Zn-Fe system kirsite that elementary composition use this area conventional method in embodiment 1 ~ 5 is obtained, result as shown in Table 2.
Table two
The present embodiment is according to GB/T228.1-2010 testing standard, and carry out stretching mechanical property testing to Zn-Fe system kirsite embodiment 1 ~ 5, result as shown in Table 2.Find that Zn-Fe system kirsite yield strength reaches as high as 380MPa, fracture elongation is up to 28%, this is because ferrum and zinc generate the tiny compound particle of Dispersed precipitate, reach the effect of crystal grain thinning, and the trace element added improves material mechanical performance further.
Embodiment 8
With the Zn-Fe system kirsite that elementary composition use this area conventional method in embodiment 1 ~ 5 is obtained, carry out vitro cytotoxicity test.
The present embodiment has carried out vitro cytotoxicity test according to GB/T 16886.5-2003 to kirsite, fibroblast L-929 is cultivated in the extracting solution of kirsite catabolite, measure the cytoactive of 24 hours and 72 hours, and compare in the cytoactive of cellar culture liquid with cultivation, find that the cytoactive of cultivation in kirsite catabolite extracting solution is all higher than 90%, and cell morphology is in the pink of condition, therefore can think that kirsite catabolite does not affect cytoactive, cell does not have toxic reaction to kirsite catabolite.
Embodiment 9
With Zn-Fe system kirsite obtained in embodiment 3, carry out et al. Ke test.Zn-Fe system kirsite embodiment 3 prepared is made filament and to be implanted in New Zealand white rabbit ventral aorta 12 months, as shown in Figure 1, in figure, clear zone is B alloy wire cross section, and the gray area being close to B alloy wire is catabolite, and black region is the resin material of fixed sample.Research finds that B alloy wire does not find the situation of any expansion and migration after degradation, and its catabolite still maintains original shape, not have discovery to drop the phenomenon of granule, fragment.Carry out et al. Ke test equally to Zn-Fe system kirsite prepared by embodiment 4 and 5, the micro-image obtained is similar to the Zn-Fe system kirsite with embodiment 3 simultaneously.
Above content is the further description done the present invention in conjunction with concrete embodiment, can not assert that specific embodiment of the invention is confined to these explanations.For general technical staff of the technical field of the invention, without departing from the inventive concept of the premise, some simple deduction or replace can also be made, all should be considered as belonging to protection scope of the present invention.
Claims (6)
1. the degradable corrosion-proof and high-strength of a human body tough Zn-Fe system kirsite, is characterized in that: described kirsite comprises Zn and Fe element; Wherein the mass percentage of Zn element is: the mass percentage of 90 ~ 99.998%, Fe element is: 0.002 ~ 10%.
2. the tough Zn-Fe system of the degradable corrosion-proof and high-strength of human body as claimed in claim 1 kirsite, is characterized in that: in described kirsite, the mass percentage of Zn element is: the mass percent of 92 ~ 99.995%, Fe element is 0.005 ~ 8%.
3. the tough Zn-Fe system of the degradable corrosion-proof and high-strength of human body as claimed in claim 1 or 2 kirsite, it is characterized in that: in described kirsite, also comprise trace element, described trace element is at least one in Mg, Ca, Sr, Li, Si, Mn and rare earth element, and the mass ratio of described trace element and Zn element is 0 ~ 0.056:1.
4. the tough Zn-Fe system of the degradable corrosion-proof and high-strength of human body as claimed in claim 3 kirsite, is characterized in that: the mass ratio of described kirsite medium trace element and Zn element is 0 ~ 0.023:1.
5. the application in degradable medical apparatus material prepared by the degradable corrosion-proof and high-strength of the human body according to any one of a Claims 1 to 4 tough Zn-Fe system kirsite.
6. the application in degradable medical apparatus material prepared by the tough Zn-Fe system of the degradable corrosion-proof and high-strength of human body as claimed in claim 5 kirsite, it is characterized in that: described degradable medical apparatus is implant frame, orthopaedics implantation instrument, gear division implantation instrument, operation suture thread or anastomat; Wherein implant frame comprises intravascular stent, trachea bracket, urethra rack, esophageal stents appear, intestinal stent or biliary tract rack; Orthopaedics implantation instrument comprises fixed screw, fixing rivet, hone lamella, bone cover, intramedullary needle or bone tissue restoration support; Anastomat comprises bowel anastomosis device, blood vessel anastomat or neural anastomosis device.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510112259.XA CN104689369B (en) | 2015-03-13 | 2015-03-13 | A kind of tough Zn-Fe systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
| PCT/CN2016/073438 WO2016145957A1 (en) | 2015-03-13 | 2016-02-04 | Corrosion-resistant, high strength and ductility zn-fe zinc alloy degradable by human body and applications of the alloy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201510112259.XA CN104689369B (en) | 2015-03-13 | 2015-03-13 | A kind of tough Zn-Fe systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104689369A true CN104689369A (en) | 2015-06-10 |
| CN104689369B CN104689369B (en) | 2017-06-30 |
Family
ID=53337180
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201510112259.XA Active CN104689369B (en) | 2015-03-13 | 2015-03-13 | A kind of tough Zn-Fe systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
Country Status (2)
| Country | Link |
|---|---|
| CN (1) | CN104689369B (en) |
| WO (1) | WO2016145957A1 (en) |
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145957A1 (en) * | 2015-03-13 | 2016-09-22 | 西安爱德万思医疗科技有限公司 | Corrosion-resistant, high strength and ductility zn-fe zinc alloy degradable by human body and applications of the alloy |
| CN106474545A (en) * | 2015-08-28 | 2017-03-08 | 先健科技(深圳)有限公司 | Available iron based alloy implanted medical device |
| CN106606800A (en) * | 2015-10-21 | 2017-05-03 | 北京大学 | Zn-Fe system zinc alloy and preparation method and application thereof |
| CN106890356A (en) * | 2016-03-10 | 2017-06-27 | 山东瑞安泰医疗技术有限公司 | A kind of degradable zinc-containing alloy implantation material and preparation method and application |
| CN106955374A (en) * | 2016-01-08 | 2017-07-18 | 先健科技(深圳)有限公司 | Implantable device |
| CN106974718A (en) * | 2016-01-15 | 2017-07-25 | 西安爱德万思医疗科技有限公司 | A kind of bone screw |
| CN107460372A (en) * | 2016-06-02 | 2017-12-12 | 北京大学 | A kind of Zn Mn systems kirsite and preparation method and application |
| CN110241453A (en) * | 2019-04-25 | 2019-09-17 | 西南大学 | A kind of degradable zinc alloy bone nail with slow release of fluorine and cerium and preparation method thereof |
| CN110512117A (en) * | 2019-09-27 | 2019-11-29 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
| CN113106295A (en) * | 2021-03-16 | 2021-07-13 | 北京科技大学 | Degradable biomedical material Zn-Si-X series zinc alloy and preparation method thereof |
| CN115874104A (en) * | 2022-11-25 | 2023-03-31 | 常州大学 | Medical degradable ZnFeMn medium-entropy alloy and preparation method and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11351290B1 (en) | 2020-04-08 | 2022-06-07 | Admtech, Llc | Absorbable high-strength zinc alloy for medical implants |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1792381A (en) * | 2005-12-22 | 2006-06-28 | 上海交通大学 | Multi-elements magnesium alloy contg. Mg-Zn-Ca-Fe of bio-absorbable type |
| WO2009158333A2 (en) * | 2008-06-25 | 2009-12-30 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion |
| CN102605390A (en) * | 2012-03-31 | 2012-07-25 | 大连理工大学 | Electroforming method for preparing degradable Fe-Zn alloy tubing for vascular stents |
| CN102634725A (en) * | 2012-03-31 | 2012-08-15 | 大连理工大学 | A biomedical corrosion-degradable binary Fe-Zn alloy material |
| CN103736152A (en) * | 2013-12-26 | 2014-04-23 | 西安爱德万思医疗科技有限公司 | Anti-corrosion high-toughness zinc alloy implant material capable of being absorbed by human body |
| CN104195369A (en) * | 2014-08-21 | 2014-12-10 | 北京大学 | Zn-Ca series zinc alloy as well as preparation method and application of Zn-Ca series zinc alloy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1172011C (en) * | 2001-09-17 | 2004-10-20 | 中国人民解放军海军工程大学 | Seawater Corrosion Resistant Zinc Alloy for Thermal Spraying and Its Technology |
| EP2111482A2 (en) * | 2007-02-13 | 2009-10-28 | Cinvention Ag | Medical devices with extended or multiple reservoirs |
| CN104689369B (en) * | 2015-03-13 | 2017-06-30 | 西安爱德万思医疗科技有限公司 | A kind of tough Zn-Fe systems kirsite of the degradable corrosion-proof and high-strength of human body and its application |
-
2015
- 2015-03-13 CN CN201510112259.XA patent/CN104689369B/en active Active
-
2016
- 2016-02-04 WO PCT/CN2016/073438 patent/WO2016145957A1/en active Application Filing
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1792381A (en) * | 2005-12-22 | 2006-06-28 | 上海交通大学 | Multi-elements magnesium alloy contg. Mg-Zn-Ca-Fe of bio-absorbable type |
| WO2009158333A2 (en) * | 2008-06-25 | 2009-12-30 | Boston Scientific Scimed, Inc. | Medical devices for delivery of therapeutic agent in conjunction with galvanic corrosion |
| CN102605390A (en) * | 2012-03-31 | 2012-07-25 | 大连理工大学 | Electroforming method for preparing degradable Fe-Zn alloy tubing for vascular stents |
| CN102634725A (en) * | 2012-03-31 | 2012-08-15 | 大连理工大学 | A biomedical corrosion-degradable binary Fe-Zn alloy material |
| CN103736152A (en) * | 2013-12-26 | 2014-04-23 | 西安爱德万思医疗科技有限公司 | Anti-corrosion high-toughness zinc alloy implant material capable of being absorbed by human body |
| CN104195369A (en) * | 2014-08-21 | 2014-12-10 | 北京大学 | Zn-Ca series zinc alloy as well as preparation method and application of Zn-Ca series zinc alloy |
Non-Patent Citations (2)
| Title |
|---|
| D. VOJTEˇCH等: ""Mechanical and corrosion properties of newly developed biodegradable Zn-based alloys for bone fixation"", 《ACTA BIOMATERIALIA》 * |
| 王伟强等: ""Fe-Zn合金的粉末冶金法制备及其生物降解特性研究"", 《功能材料》 * |
Cited By (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016145957A1 (en) * | 2015-03-13 | 2016-09-22 | 西安爱德万思医疗科技有限公司 | Corrosion-resistant, high strength and ductility zn-fe zinc alloy degradable by human body and applications of the alloy |
| CN106474545A (en) * | 2015-08-28 | 2017-03-08 | 先健科技(深圳)有限公司 | Available iron based alloy implanted medical device |
| US10946121B2 (en) | 2015-08-28 | 2021-03-16 | Biotyx Medical (Shenzhen) Co., Ltd. | Absorbable iron-based alloy implantable medical device |
| CN106606800A (en) * | 2015-10-21 | 2017-05-03 | 北京大学 | Zn-Fe system zinc alloy and preparation method and application thereof |
| CN106606800B (en) * | 2015-10-21 | 2019-05-14 | 北京大学 | A kind of Zn-Fe system kirsite and the preparation method and application thereof |
| CN106955374A (en) * | 2016-01-08 | 2017-07-18 | 先健科技(深圳)有限公司 | Implantable device |
| CN106974718A (en) * | 2016-01-15 | 2017-07-25 | 西安爱德万思医疗科技有限公司 | A kind of bone screw |
| US20190083685A1 (en) * | 2016-03-10 | 2019-03-21 | Shandong Rientech Medical Tech Co., Ltd. | Degradable zinc base alloy implant material and preparation method and use thereof |
| US12109337B2 (en) * | 2016-03-10 | 2024-10-08 | Shandong Rientech Medical Tech Co., Ltd. | Degradable zinc base alloy implant material and preparation method and use thereof |
| CN106955376A (en) * | 2016-03-10 | 2017-07-18 | 山东瑞安泰医疗技术有限公司 | A kind of application of degradable zinc-containing alloy implantation material in orthopaedics implant is prepared |
| CN106913916A (en) * | 2016-03-10 | 2017-07-04 | 山东瑞安泰医疗技术有限公司 | A kind of application of degradable zinc-containing alloy implantation material in intravascular stent is prepared |
| WO2017152878A1 (en) * | 2016-03-10 | 2017-09-14 | 山东瑞安泰医疗技术有限公司 | Degradable zinc base alloy implant material and preparation method and use thereof |
| CN106890356B (en) * | 2016-03-10 | 2020-07-24 | 山东瑞安泰医疗技术有限公司 | Degradable zinc-based alloy implant material and preparation method and application thereof |
| CN106890356A (en) * | 2016-03-10 | 2017-06-27 | 山东瑞安泰医疗技术有限公司 | A kind of degradable zinc-containing alloy implantation material and preparation method and application |
| CN107460372A (en) * | 2016-06-02 | 2017-12-12 | 北京大学 | A kind of Zn Mn systems kirsite and preparation method and application |
| CN107460372B (en) * | 2016-06-02 | 2019-06-25 | 北京大学 | A kind of Zn-Mn system kirsite and the preparation method and application thereof |
| CN110241453A (en) * | 2019-04-25 | 2019-09-17 | 西南大学 | A kind of degradable zinc alloy bone nail with slow release of fluorine and cerium and preparation method thereof |
| CN110512117A (en) * | 2019-09-27 | 2019-11-29 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
| CN110512117B (en) * | 2019-09-27 | 2022-05-13 | 石家庄新日锌业有限公司 | Medical zinc alloy material and preparation method thereof |
| CN113106295A (en) * | 2021-03-16 | 2021-07-13 | 北京科技大学 | Degradable biomedical material Zn-Si-X series zinc alloy and preparation method thereof |
| CN115874104A (en) * | 2022-11-25 | 2023-03-31 | 常州大学 | Medical degradable ZnFeMn medium-entropy alloy and preparation method and application thereof |
| CN115874104B (en) * | 2022-11-25 | 2024-05-03 | 常州大学 | Medical degradable ZnFeMn medium entropy alloy and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104689369B (en) | 2017-06-30 |
| WO2016145957A1 (en) | 2016-09-22 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN104689369A (en) | Degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for human body and application thereof | |
| CN104689378B (en) | A kind of tough Zn-Fe-X systems kirsite of the degradable corrosion-proof and high-strength of human body and its application | |
| CN104651664B (en) | A kind of tough Zn-Fe-RE systems kirsite of the degradable corrosion-proof and high-strength of human body and its application | |
| CN104651665B (en) | A kind of tough Zn-Fe-Li systems kirsite of the degradable corrosion-proof and high-strength of human body and its application | |
| Wang et al. | Research progress of biodegradable magnesium-based biomedical materials: A review | |
| CN109680195B (en) | A kind of Mg-RE series magnesium alloy and its preparation method and application | |
| CN105671391B (en) | Fully-degradable magnesium alloy and preparation method thereof | |
| CN108754232B (en) | A high-strength and high-plastic biodegradable Zn-Mn-Li series zinc alloy and use thereof | |
| WO2017084363A1 (en) | Medical degradable zn-cu-x alloy material and preparation method thereof | |
| CN108315583B (en) | Zn-Li-Mn zinc alloy and preparation method and application thereof | |
| CN111334688A (en) | A kind of Zn-RE series zinc alloy and its preparation method and application | |
| CN105986146B (en) | A kind of degradable medical is metal material embedded and preparation method thereof | |
| Niu et al. | The effects of Cu and Mn on the microstructure, mechanical, corrosion properties and biocompatibility of Zn–4Ag alloy | |
| CN101837145A (en) | High-toughness corrosion-resistant magnesium alloy implanted material capable of being degraded in organism | |
| WO2020042745A1 (en) | Mg-zn-sn series magnesium alloy with controllable degradation rate, preparation method and application thereof | |
| CN108277386A (en) | A kind of Zn-Li-Mg systems kirsite and the preparation method and application thereof | |
| Sun et al. | Biodegradable Zn-0.5 Li alloy rib plate: Processing procedure development and in vitro performance evaluation | |
| CN106282664A (en) | Biodegradable medical zinc lithium binary alloy material and preparation method and application | |
| Yan et al. | Comparison of the effects of Mg–6Zn and Ti–3Al–2.5 V alloys on TGF-β/TNF-α/VEGF/b-FGF in the healing of the intestinal tract in vivo | |
| CN104511049B (en) | A kind of biological medical degradable metal treating rheumatoid arthritis and application thereof | |
| CN111809090A (en) | A kind of medical degradable Mg-Pr series magnesium alloy and its preparation method and application | |
| CN108165782A (en) | A kind of medical zinc-containing alloy band and preparation method thereof | |
| EP3395971B1 (en) | Alloy material and application thereof | |
| CN108728770A (en) | A kind of superelevation anti-microbial property austenitic stainless steel applied to medical embedded holder | |
| CN104451269B (en) | A kind of cobalt-base alloys and its hot-working, heat treatment method and application |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| TA01 | Transfer of patent application right | ||
| TA01 | Transfer of patent application right |
Effective date of registration: 20170601 Address after: Two Shaanxi city of Xi'an province high tech Zone Industrial Park Jin industry Xinkai building A layer Applicant after: XI'AN ADVANCED MEDICAL TECHNOLOGY Co.,Ltd. Address before: Delaware Applicant before: Zhou Gongyao |
|
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| EE01 | Entry into force of recordation of patent licensing contract |
Application publication date: 20150610 Assignee: Shaanxi Chunhui bioco medical technology LLC Assignor: XI'AN ADVANCED MEDICAL TECHNOLOGY Co.,Ltd. Contract record no.: 2017610000020 Denomination of invention: Degradable corrosion-resistant high-toughness Zn-Fe zinc alloy for human body and application thereof Granted publication date: 20170630 License type: Exclusive License Record date: 20170713 |
|
| EE01 | Entry into force of recordation of patent licensing contract | ||
| EC01 | Cancellation of recordation of patent licensing contract | ||
| EC01 | Cancellation of recordation of patent licensing contract |
Assignee: Shaanxi Chunhui bioco medical technology LLC Assignor: XI'AN ADVANCED MEDICAL TECHNOLOGY Co.,Ltd. Contract record no.: 2017610000020 Date of cancellation: 20180426 |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240712 Address after: Room 801, Building B, Hanguang Jiayuan Community, No. 67 Gaoxin Road, Xi'an City, Shaanxi Province, China 710073 Patentee after: Xue Yong Country or region after: China Address before: 710000 first floor, building a, Xinkai Industrial Park, Jinye Second Road, high tech Zone, Xi'an, Shaanxi Province Patentee before: XI'AN ADVANCED MEDICAL TECHNOLOGY Co.,Ltd. Country or region before: China |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240717 Address after: No. 801, Building B, Hanguang Jiayuan, No. 67 Gaoxin Road, Xi'an City, Shaanxi Province, China 710073 Patentee after: Qu Gongqi Country or region after: China Address before: Room 801, Building B, Hanguang Jiayuan Community, No. 67 Gaoxin Road, Xi'an City, Shaanxi Province, China 710073 Patentee before: Xue Yong Country or region before: China |
|
| TR01 | Transfer of patent right | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240919 Address after: No. 68 Jinzhou North Road, Ningxiang High tech Industrial Park, Changsha City, Hunan Province 410600 Patentee after: Hunan Huaxiang Medical Technology Co.,Ltd. Country or region after: China Address before: No. 801, Building B, Hanguang Jiayuan, No. 67 Gaoxin Road, Xi'an City, Shaanxi Province, China 710073 Patentee before: Qu Gongqi Country or region before: China |