CN104666992B - The Chinese medicine composition that hepatic and renal function caused by a kind of mitigation AIDS antiviral drugs damages - Google Patents

Abstract

The invention discloses the Chinese medicine compositions that hepatic and renal function caused by a kind of mitigation AIDS antiviral drugs damages, which is characterized in that the Chinese medicine preparation is made of the Chinese medicine material of following parts by weight：15~25 parts of moutan bark, 8~12 parts of Chinese yam, 20~30 parts of Poria cocos, 6~10 parts of Rhizoma Atractylodis Macrocephalae, 15~25 parts of rough gentian, 8~12 parts of Radix Astragali, 14~18 parts of Radix Angelicae Sinensis, 6~10 parts of Radix Paeoniae Alba, 4~8 parts of corn stigma.For treating the illnesss such as liver hematopoietic deficiency, low blood pressure, incomplete brain blood supply, angina pectoris, hepatic and renal function caused by can effectively mitigating AIDS antiviral drugs damages the product of drug of the present invention, has the advantages that treatment speed is fast, curative effect is high, treatment cost is low etc..

Description

A traditional Chinese medicine group for alleviating liver and kidney function damage caused by AIDS antiviral drugs compound

【Technical field】

The invention relates to the technical field of medicine, in particular to a traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs.

【Technical field】

AIDS (highly active antiretroviral therapy for HAART) is a disease of immune system damage caused by viral infection. The adverse reactions of AIDS patients are related to the choice of antiviral therapy. Most of the adverse reactions of AIDS patients occur in the first day after treatment. within a month. CD4+ T cell counts increased in most patients after antiviral treatment. At present, there is still no cure, but antiviral treatment can effectively prolong the survival period of patients and improve the quality of life of patients, but long-term antiviral treatment will cause many adverse reactions in patients, such as common gastrointestinal symptoms, neuromuscular system adverse reactions , as well as severe liver and kidney function impairment, bone marrow suppression, etc., once adverse reactions occur, it will have a certain impact on the compliance of patients receiving antiviral treatment. The traditional Chinese medicine composition adopted in the present invention can reduce the damage of liver and kidney function caused by AIDS antiviral drugs, treat according to syndrome differentiation, attack and complement, treat both symptoms and root causes, and is used in clinical trials to reduce the cases of liver and kidney function damage caused by AIDS antiviral drugs It has achieved remarkable therapeutic effects, is safe and has no side effects.

【Content of invention】

The object of the present invention is to provide a kind of traditional Chinese medicine composition that can effectively alleviate the damage of liver and kidney function caused by AIDS antiviral drugs, and the traditional Chinese medicine composition for reducing the damage of liver and kidney function caused by AIDS antiviral drugs can effectively The treatment of hepatic hematopoietic insufficiency, hypotension, cerebral insufficiency, angina pectoris and other diseases can effectively alleviate the liver and kidney function damage caused by AIDS antiviral drugs, and the treatment speed is fast, the curative effect is high, and the treatment cost is low.

Technical scheme of the present invention is:

The traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs has the following main raw materials and parts by weight: 15-25 parts of Cortex Moutan, 8-12 parts of Chinese yam, 20-30 parts of Poria cocos, 6-10 parts of Atractylodes macrocephala, 15-25 parts of gentian, 8-12 parts of astragalus, 14-18 parts of angelica, 6-10 parts of white peony, and 4-8 parts of corn silk.

Further, the traditional Chinese medicine composition for reducing liver and kidney function damage caused by AIDS antiviral drugs has the following main raw materials and parts by weight: 20 parts of Moutan cortex, 10 parts of Chinese yam, 25 parts of Poria cocos, 8 parts of Atractylodes macrocephala, 20 parts of gentian, 10 parts of astragalus, 16 parts of angelica, 8 parts of white peony, and 6 parts of corn silk.

According to the conventional preparation process of related dosage forms, the medicine for alleviating liver and kidney function damage caused by AIDS antiviral drugs of the present invention is made into corresponding dosage forms by adding appropriate amount of auxiliary materials. The above-mentioned medicines can be made into oral liquid, capsules, tablets, granules or other Pharmaceutically acceptable dosage forms.

The production method of the above-mentioned oral liquid for reducing liver and kidney function damage caused by AIDS antiviral drugs is to take Moutan Cortex, Chinese Yam, Poria, Atractylodes Rhizoma Atractylodes Rhizome, Gentiana, Radix Astragali, Angelica, Radix Paeoniae Alba, and Corn Silk in proportion by weight. Add 4-6 times the total amount of water and decoct three times, each time for 2 hours, combine the decoction, filter, add medically approved pharmaceutical excipients, and make an oral liquid.

The production method of the above-mentioned preparation for alleviating the liver and kidney function damage caused by AIDS antiviral drugs is characterized in that: Cortex Moutan, Chinese yam, Poria cocos, Atractylodes macrocephala, Gentiana, Radix Astragali, Angelica sinensis, Radix Paeoniae Alba, corn Add water 4-6 times according to the total weight and decoct three times, 2 hours each time, combine the decoction, filter and concentrate to a thick paste with a relative density of 1.30-1.32, then dry below 80°C, grind into fine powder, add Excipients, mixed well, made into capsules, tablets or granules.

Chinese medicine details among the present invention are as follows:

Cortex Moutan, heat-clearing, promoting blood circulation and dissipating blood stasis, mainly treating febrile disease, spotting, spit bleed, hot tears filling the eyes, pathogenic bacteria in the later stage, hot volts, hot flashes, blood stagnation, amenorrhea, dysmenorrhea, carbuncle sores, fall Flutter pain, rheumatic heat arthralgia effect.

Yam, also known as yam, yam, yam, Chinese yam, yam, and white yam, has nourishing and strong effects, helps digestion, suppresses sweating, and relieves diarrhea. Chronic enteritis with frequency, nocturnal emission, women's leukorrhagia and indigestion.

Poria cocos, commonly known as Yunling, Songling and Poria cocos, is a porous fungus Poria cocos. The combination of medicines can exert its unique effects regardless of cold, temperature, wind and damp diseases. Poria cocos is flat in nature, sweet and light in taste, and has the functions of diuresis and dampness, benefiting the spleen and stomach, calming the mind and calming the nerves.

Atractylodes macrocephala, also known as: Dongbaizhu, Yuzhu, Dongzhu, has the functions of adjusting gastrointestinal motility, anti-ulcer, protecting the liver, enhancing the immune function of the body, anti-stress, enhancing hematopoietic function, anti-oxidation, delaying aging, lowering blood sugar, anti-aging Coagulation, anti-tumor and other effects.

Angelica, warm in nature, sweet and pungent in taste. GUIXIN, liver, spleen channel. Enrich blood and blood, regulate menstruation and relieve pain, moisten dryness and smooth intestines. Control irregular menstruation, amenorrhea abdominal pain, mass in the abdomen, metrorrhagia, blood deficiency headache, dizziness, impotence; dryness of the intestines, difficulty in defecation, severe diarrhea after redness; carbuncle sores, injuries from falls.

Astragalus can enhance the immune function of the body, protect the liver, diuretic, anti-aging, anti-stress, lower blood pressure and have a wide range of antibacterial effects. It can eliminate experimental nephritis proteinuria, enhance myocardial contractility, and regulate blood sugar levels.

Gentiana, purging liver and gallbladder excess fire, removes damp-heat in lower burnt. Control excessive heat in the liver meridian, convulsions, epilepsy and mania, Japanese encephalitis, headache, red eyes, sore throat, jaundice, dysentery, carbuncle sores, swollen and painful scrotum, and wet itching in the genitals. For damp heat jaundice, pruritus vulvae, vaginal discharge, eczema itching, deafness, hypochondriac pain, bitter mouth, convulsions and convulsions.

Radix Paeoniae Alba, cool in nature, bitter in taste, slightly cold, has the functions of nourishing blood and nourishing blood, calming liver yang, softening liver and relieving pain, astringing yin and antiperspirant, etc. Convulsions, dysentery, abdominal pain, spontaneous sweating, metrorrhagia, leukorrhea embolism.

Corn silk, flat in nature, sweet and light in taste, non-toxic. Go into liver, kidney, urinary bladder channel. Diuretic, expel heat, calm the liver, promote choleresis. Control nephritis edema, beriberi, jaundice hepatitis, hypertension, cholecystitis, gallstones, diabetes, hematemesis and epistaxis, nasal sinusitis, mastitis.

The present invention adopts the above technical scheme, and compared with the prior art, it has the following advantages: the product of the medicine of the present invention is used to treat diseases such as hepatic hematopoietic insufficiency, hypotension, cerebral insufficiency, angina pectoris, etc., and can effectively alleviate the symptoms caused by AIDS antiviral drugs. It has the advantages of fast treatment speed, high curative effect and low treatment cost.

The technical solutions of the present invention will be further described below in conjunction with specific embodiments.

【Detailed ways】

Example 1

A traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs, which is composed of the following components classified by weight (1g per part);

15 parts of Moutan cortex, 8 parts of Chinese yam, 20 parts of Poria cocos, 6 parts of Atractylodes macrocephala, 15 parts of gentian, 8 parts of astragalus, 14 parts of angelica, 6 parts of white peony, 4 parts of corn silk, according to the above ingredients and proportions, decocting method Extract three times, first add water according to the material-liquid ratio of 1:8, soak for 30 minutes, boil for extraction for 30 minutes, filter with a 300-mesh filter cloth, and use the filtrate for later use; Filter the filtrate for later use; add water to the dregs according to the material-to-liquid ratio of 1:4, boil and extract for 30 minutes, filter through a 300-mesh filter cloth, combine the filtrate three times, concentrate to 1:1, let stand for 48 hours, filter, and concentrate the filtrate to a relative density of 1.15 , that is to obtain the extract of the raw material, and then add pharmaceutical excipients to dilute to make an oral liquid.

Example 2

A traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs, which is composed of the following components classified by weight (1g per part);

20 parts of Moutan bark, 10 parts of Chinese yam, 25 parts of Poria cocos, 8 parts of Atractylodes macrocephala, 20 parts of gentian, 10 parts of astragalus, 14 parts of angelica, 8 parts of white peony, 6 parts of corn silk, according to the above ingredients and proportions, decocting method Extract three times, first add water according to the material-liquid ratio of 1:8, soak for 30 minutes, boil for extraction for 30 minutes, filter with a 300-mesh filter cloth, and use the filtrate for later use; Filter the filtrate for later use; add water to the dregs according to the material-to-liquid ratio of 1:4, boil and extract for 30 minutes, filter through a 300-mesh filter cloth, combine the filtrate three times, concentrate to 1:1, let stand for 48 hours, filter, and concentrate the filtrate to a relative density of 1.15 , that is to obtain the extract of the raw material, then add pharmaceutical excipients PEG4000 and dextrin, make it bonded with water or starch slurry, dry it directly with a dry granulator or wet granulate, then dry, crush, add excipients to granulate, pack into the capsule shell to obtain a capsule.

Example 3

A traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs, which is composed of the following components classified by weight (1g per part);

25 parts of Moutan bark, 12 parts of Chinese yam, 30 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 25 parts of gentian, 12 parts of astragalus, 16 parts of angelica, 10 parts of white peony, and 8 parts of corn silk. Extract three times, first add water according to the material-liquid ratio of 1:8, soak for 30 minutes, boil for extraction for 30 minutes, filter with a 300-mesh filter cloth, and use the filtrate for later use; Filter the filtrate for later use; add water to the dregs according to the material-to-liquid ratio of 1:4, boil and extract for 30 minutes, filter through a 300-mesh filter cloth, combine the filtrate three times, concentrate to 1:1, let stand for 48 hours, filter, and concentrate the filtrate to a relative density of 1.15 , that is to obtain the extract of the raw material, add pharmaceutical excipients lactose, PEG4000, magnesium stearate to the raw material extract prepared above, bind it with water or starch slurry, and directly granulate it with a dry granulator or wet process After granulation, dry, granulate, and compress with a tablet machine to obtain tablets.

Example 4

A traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs, which is composed of the following components classified by weight (1g per part);

25 parts of Moutan bark, 12 parts of Chinese yam, 30 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 25 parts of gentian, 12 parts of astragalus, 16 parts of angelica, 10 parts of white peony, and 8 parts of corn silk. Extract three times, first add water according to the material-liquid ratio of 1:8, soak for 30 minutes, boil for extraction for 30 minutes, filter with a 300-mesh filter cloth, and use the filtrate for later use; Filter the filtrate for later use; add water to the dregs according to the material-to-liquid ratio of 1:4, boil and extract for 30 minutes, filter through a 300-mesh filter cloth, combine the filtrate three times, concentrate to 1:1, let stand for 48 hours, filter, and concentrate the filtrate to a relative density of 1.15 , that is to obtain the extract of the raw material, add the pharmaceutical excipient sodium carboxymethyl starch to the raw material extract prepared above, make it stick with water, use a dry granulator to directly granulate or wet granulate, then dry and granulate , subpackaged to obtain granules.

Case 1

AIDS-infected person Qiu Moumou, from Yulin City, Guangxi, had symptoms such as persistent low-grade fever, dizziness, and nausea in 2010. In 2011, he had a blood test at the People’s Hospital of Yulin City, Guangxi. He was positive for HIV in the initial screening and was later confirmed to be HIV by a confirmatory test. infected. He began to receive cocktail therapy in 2012. At that time, the CD4 cell count was 531 and his weight was 60kg. After being treated with AIDS antiviral drugs, he began to experience dizziness, hypotension (blood pressure 60/51mmhg), pale face, and spirit in January 2013. Extremely poor, weight loss, fatigue, spontaneous sweating, easy to catch a cold, an average of 10 times a month, diarrhea, an average of 5 times a day, watery stools, chills from time to time, acid regurgitation, clear water spit, deep and weak pulse, pale tongue with white coating, Self-service antidiarrheal medicine, no improvement, then come to the hospital for medical treatment, measuring CD4 cell count is 301, body weight 48kg, Chinese medicine diagnosis is diarrhea, spleen and kidney yang deficiency, impaired liver function, taking the oral liquid of the embodiment of the present invention 1, Three times a day, 20ml each time, in May 2014, the CD4 cell count was 526, the dizziness and headache disappeared, the blood pressure (90/80mmhg) was measured, and the spirit was full.

Case 2

Jiang Moumou, an HIV-infected person from Gangbei District, Guigang City, has experience in drug abuse, frequently used syringes to take drugs, and shared syringes with others many times. In early 2012, he was initially screened positive for HIV when he was hospitalized due to high fever, and was later confirmed HIV positive by experiment. Infect. At that time, the CD4 cell count was 576. After being treated with AIDS antiviral drugs, in January 2013, he began to experience physical fatigue, weight loss, spontaneous sweating, susceptibility, dizziness, hypotension (blood pressure 64/50mmhg), yellow and pale complexion, The spirit is extremely poor, sometimes chills, sometimes acid regurgitation, spit clear water, slow and weak pulse, pale tongue with white coating, self-administration of western medicine, but no improvement, so I came to our center for treatment, and the CD4 cell count was 212. For impotence, deficiency of spleen and kidney yang, and impaired liver function, take the capsule of Example 2 of the present invention, three times a day, three capsules each time, in March 2014, the CD4 cell count was 423, dizziness and headache disappeared, and the blood pressure was measured Value (95/68mmhg), full of energy.

Case 3

An HIV-infected patient named Ye, a farmer, from Heng County, Guangxi, was found to be HIV-positive in 2010. After being hospitalized due to persistent high fever in March 2012, he was diagnosed as an HIV-infected person by the Guangxi CDC. At that time, the CD4 cell count was 511, and after treatment with AIDS antiviral drugs, she began to suffer from weight loss, fatigue, spontaneous sweating, colds, dizziness, hypotension (blood pressure 71/56mmhg), yellowish and pale complexion in April 2013. Have acid reflux, spit clear water, deep and slow pulse, pale tongue with white fur, self-administration of western medicine, no improvement. Through visiting our center, prescription is the embodiment of the present invention 3 tablets, every day three times, each three, every about 1.2g, measure CD4 cell count and be 433, dizziness, headache disappear, measure blood pressure value (93/71mmhg ), full of energy.

Case 4

An HIV-infected person named Zhou, from Laibin City, Guangxi, had a low-grade fever that persisted in 2012. He was found to be HIV-positive upon admission to the hospital, and was diagnosed as an HIV-infected person by the Guangxi District CDC. At that time, the CD4 cell count was 456, and after treatment with AIDS antiviral drugs, in October 2013, he began to experience weight loss, fatigue, spontaneous sweating, susceptibility, dizziness, hypotension (blood pressure 71/56mmhg), yellow and pale complexion , acid regurgitation from time to time, spit clear water, deep and slow pulse, pale tongue with white fur. In November 2013, I came to our center to see a doctor and prescribed the granules of Example 4 of the present invention, three times a day, three capsules each time, each capsule was about 1.2g, and in December 2014, the CD4 cell count was 411, dizziness, The headache disappears, the blood pressure (90/65mmhg) is measured, and the spirit is full.

clinical conclusion

The clinical results show that after 6 months of combined application of the traditional Chinese medicine and AIDS antiviral, the symptoms of HIV-infected patients such as liver hematopoietic insufficiency, hypotension, cerebral insufficiency, and angina pectoris have been effectively alleviated. It shows that the traditional Chinese medicine of the present invention can alleviate the liver and kidney function damage caused by AIDS antiviral drugs.

Claims (5)

1. A traditional Chinese medicine composition for alleviating liver and kidney damage caused by AIDS antiviral drugs, characterized in that: it is made of the following raw materials in parts by weight: 15-25 parts of Cortex Moutan, 8-12 parts of Chinese yam, 20 parts of Poria cocos ～30 parts, 6-10 parts of Atractylodes macrocephala, 15-25 parts of gentian, 8-12 parts of astragalus, 14-18 parts of angelica, 6-10 parts of white peony root, 4-8 parts of corn silk; A pharmaceutically acceptable auxiliary material or carrier is added to the raw material, and the composition is made into oral liquid, capsule, tablet or granule. 2. The traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs according to claim 1, characterized in that: the composition is made of the following raw materials in parts by weight: 15-25 parts of Cortex Moutan, 8-12 parts of yam, 20-30 parts of poria cocos, 6-10 parts of Atractylodes macrocephala, 15-25 parts of gentian, 8-12 parts of astragalus, 14-18 parts of angelica, 6-10 parts of white peony, 4-8 parts of corn silk . 3. The traditional Chinese medicine composition for alleviating liver and kidney function damage caused by AIDS antiviral drugs according to claim 1 or 2, characterized in that: the composition is made of the following raw materials in parts by weight: 15 parts of Cortex Moutan, 8 parts of yam, 20 parts of Poria cocos, 6 parts of Atractylodes macrocephala, 15 parts of gentian, 8 parts of astragalus, 14 parts of angelica, 6 parts of white peony, and 4 parts of corn silk. 4. The traditional Chinese medicine composition for reducing liver and kidney function damage caused by AIDS antiviral drugs according to claim 1 or 2, characterized in that: the composition is made of the following raw materials in parts by weight: 20 parts of Cortex Moutan, 10 parts of yam, 25 parts of Poria cocos, 8 parts of Atractylodes macrocephala, 20 parts of gentian, 10 parts of astragalus, 16 parts of angelica, 8 parts of white peony, and 6 parts of corn silk. 5. The traditional Chinese medicine composition for alleviating the liver and kidney function damage caused by AIDS antiviral drugs according to claim 1 or 2, characterized in that, the composition is made of the following raw materials by weight: 25 parts of Cortex Moutan, 12 parts of yam, 30 parts of Poria cocos, 10 parts of Atractylodes macrocephala, 25 parts of gentian, 12 parts of astragalus, 18 parts of angelica, 10 parts of white peony, and 8 parts of corn silk.