CN104644670B - Nipple sealer for preventing milk cow dry breast phase mammitis and preparation method thereof - Google Patents
Nipple sealer for preventing milk cow dry breast phase mammitis and preparation method thereof Download PDFInfo
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- CN104644670B CN104644670B CN201510087681.4A CN201510087681A CN104644670B CN 104644670 B CN104644670 B CN 104644670B CN 201510087681 A CN201510087681 A CN 201510087681A CN 104644670 B CN104644670 B CN 104644670B
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Abstract
The invention discloses a kind of nipple sealer for being used to prevent milk cow dry breast phase mammitis and preparation method thereof, belong to field of veterinary.The nipple sealer of the present invention is made up of the gel-type vehicle of the wt% of 40wt% 75 nontoxic metal compound, the wt% of 2 wt% 10 Gardenoside and the wt% of 10 wt% 50；Wherein gel-type vehicle is made up of the wt% of 70 wt% 90 decentralized medium, the wt% of 5 wt% 12 gel, the wt% of 2 wt% 5 suspending agent, the wt% of 0.1 wt% 0.3 antioxidant and the wt% of 0.04 wt% 0.15 preservative.Active ingredient Gardenoside cooperates with nontoxic metal compound in nipple sealer of the present invention, high for dry milk phase mastitis for milk cows cure rate, and effectively alleviates the inflammatory reaction of clinic mastitis.
Description
Technical field
The present invention relates to veterinary drug technical field, more particularly to a kind of nipple closing for being used to prevent milk cow dry breast phase mammitis
Agent and preparation method thereof.
Background technology
Mammitis is a kind of common frdquently encountered disease of milk cow, is one of main disease for influenceing dairy development, not only makes
Lactation amount and milk product quality are reduced, or even cause injury of breast, and huge economic loss is caused to dairy.At present, the world
2.2 hundred million cow heads are there are about, wherein 1/3 milk cow suffers from various types of mastitis, every year because the loss of mastitis is up to 35,000,000,000
Dollar, only the loss in the U.S. is just up to 2,000,000,000 dollars.Show that China's mastitis for milk cows is averaged according to the investigation data over 30 years
Recall rate is 50% ~ 70%, and newborn area's average positive rate is 20% ~ 40%.Although milk cattle cultivating technology and managerial skills were not in recent years
It is disconnected to improve, but the mastitis for milk cows incidence of disease still remains high.
Milk cow dry breast phase is that fetus mushrooms out the development needs more polyauxotrophic stage in Contents in Cows, and is further improved
The nutrition condition of milk cow, ensure that next lactation period can the more preferable, necessary condition of more permanently galactopoiesis.And breast occurs for dry breast phase
It inflammation, can cause the milk cow postpartum colostrum phase that mammitis occurs, thereby result in the peak of lactation Lactation of Dairy Cow in postpartum 2-3 month
It cannot can fully show, lactating cow is lost milking capacity and is eliminated when serious.
Milk cow can pad aging, poorly sealed, extension cup overlong time during long term mechanical is milked due to teatcup
" excessively crowded " phenomenon is caused etc. factor, so as to cause papillary foramina of kidney to turn up or the impaired opening of being formed of teat sphincter and keratin
Nipple, it is highly prone to the invasion of environment pathogen especially EHEC and causes the generation of mammitis.It is even normal
Dip conduit about 2h after milking can just return to closure state, if improper in this period feeding and management method, such as
Milk cow lying period is long after milking, ox bed and guardrail environmental sanitation are bad, can all cause environment pathogenic infection to trigger breast
It is scorching.
Papillary foramina of kidney sealer is a kind of hydrophobic type oleaginous base gel, can form physical barrier in papillary foramina of kidney, prevent
The intrusion of environment pathogenic bacteria is stopped.When clinical practice application is more and antibiotic is combined, breast endophyte can be played well
Killing action, but clinical research shows, and antibiotic can induce a large amount of releases of bacterial endotoxin while pathogen is killed, from
And locally cause heating pain, mammary swelling, somatic cell from milk number to increase in breast, a series of inflammation disease such as shock when serious
Reason reaction, and cure rate is low.
The content of the invention
Breast heating pain, swelling, somatic cell from milk is triggered to increase to solve existing nipple sealer and antibiotic combination
The problem of waiting inflammatory pathologies reaction and low cure rate, the invention provides a kind of breast for being used to prevent milk cow dry breast phase mammitis more
Head sealer and preparation method thereof.The nipple sealer of the present invention is used to prevent and treat as caused by bacterial endotoxin and environment pathogenic bacteria
Dry cow mammitis, and it is anti-that cow breast heating pain, swelling, somatic cell from milk will not be triggered the inflammatory pathologies such as to increase
Should.
The technical scheme is that：
A kind of nipple sealer for being used to prevent milk cow dry breast phase mammitis, by 40wt%-75 wt% nontoxic metal chemical combination
The gel-type vehicle composition of thing, 2 wt %-10 wt % Gardenoside and 10 wt %-50 wt %；Wherein described gel-type vehicle by
70 wt %-90 wt % decentralized medium, 5 wt %-12 wt % gel, 2 wt %-5 wt % suspending agent, 0.1wt
%-0.3 wt % antioxidant and 0.04 wt %-0.15 wt % preservative form.Nontoxic metal compound can form physics
Barrier.Gel-type vehicle matrix used is slow-releasing gel used in the nipple sealer of the present invention, slowly discharges Gardenoside, can ensure
It's the dry milk phase pasts milk cow degree of safety.
Preferably, by 55wt%-65 wt% nontoxic metal compound, 4wt %-6 wt % Gardenoside and 25wt %-
35wt % gel-type vehicle composition.
Further, by the gel-type vehicle group of 60wt% nontoxic metal compound, 5wt % Gardenoside and 30wt %
Into.
Preferably, the nontoxic metal compound in basic bismuth nitrate, titanium dioxide, zinc oxide, barium sulfate extremely
Few one kind.
Preferably, the decentralized medium is atoleine, fractionated coconut oil, injection soybean oil, middle carbochain fat
One kind or its combination in fatty acid glyceride, ethyl oleate；The gel is aluminum monostearate, aluminum stearate, double stearic acid
One kind or its combination in aluminium, magnesium stearate, rilanit special, carbomer；The suspending agent is silica, lanolin, list
One kind or its combination in tristerin, vaseline, beeswax, emulsifying wax；The antioxidant is 2,6- di-t-butyls to first
One kind or its combination in phenol, butylhydroxy anisole, vitamin E, propylgallate；The preservative is Metagin
One kind or its combination in ester, propylben, benzoic acid, potassium sorbate, o-phenyl phenol.
The preparation method for being used to prevent the nipple sealer of milk cow dry breast phase mammitis, is concretely comprised the following steps：
1）The nontoxic metal compound and Gardenoside are subjected to micro mist processing respectively, are 10-40 μm to particle diameter；
2）Gel, suspending agent, antioxidant, preservative are dispersed in decentralized medium, obtain gel-type vehicle；
3）By step 1）Gardenoside after micro mist processing is dispersed in the gel-type vehicle；
4）The nontoxic metal compound of 1/3 recipe quantity is added portionwise, it is stirring while adding, add 1/3 recipe quantity
10-30min is persistently stirred after nontoxic metal compound；The nontoxic metal compound of remaining 2/3 recipe quantity is added portionwise, added
10-30min is persistently stirred afterwards；Finally breast is even in high-shearing dispersion emulsifying machine；
5）Dispense and seal, obtain the nipple sealer finished product for preventing milk cow dry breast phase mammitis.
Preferably, step 1）It is middle that micro mist processing is carried out using jet mill.
Further, step 1）It is 10-25 μm that middle micro mist, which is handled to particle diameter,.
Preferably, step 2）Described in dispersed disperse using under ultrasonic disperse or heating condition.
Beneficial effects of the present invention are：
The nipple sealer of the present invention can significantly improve the cure rate of milk cow dry breast phase mammitis, effectively alleviate clinic
The inflammatory reaction of type mammitis；The present invention can effectively reduce the somatic number in milk, for as caused by bacterial endotoxin
Clinic mastitis have good therapeutic action, be it is a kind of preferably for milk cow dry breast phase mammitis preventing and treating nipple closing
Agent medicine.
Embodiment
Embodiment 1
1）Basic bismuth nitrate and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 26.43g atoleines to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add aluminum stearate 2.5g, two
Silica 1.0g, BHT 0.05g, o-phenyl phenol 0.02g, heating stirring to being completely dissolved, make its into
Gel-type vehicle, cold bath are cooled to less than 40 DEG C；
3）Take 5.0g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）20.0g basic bismuth nitrates are added portionwise, every batch adds 2.0g, stirring while adding, adds the 20.0g alkali formula nitric acid
20min is persistently stirred after bismuth；45.0g basic bismuth nitrates are added portionwise again, add 2.0g every time, it is stirring while adding, held after adding
Continuous stirring 20min；The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 2
1）Basic bismuth nitrate and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 39.93g atoleines to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add aluminum stearate 4.0g, two
Silica 1.0g, BHT 0.05g, o-phenyl phenol 0.02g, heating stirring to being completely dissolved, make its into
Gel-type vehicle, cold bath are cooled to less than 40 DEG C；
3）Take 5.0g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）15.0g basic bismuth nitrates are added portionwise, every batch adds 1.5g, stirring while adding, adds the 15.0g alkali formula nitric acid
20min is persistently stirred after bismuth；35.0g basic bismuth nitrates are added portionwise again, add 2.0g every time, it is stirring while adding, held after adding
Continuous stirring 20min；The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 3
1）Basic bismuth nitrate and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 17.43g atoleines to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add aluminum stearate 1.5g, two
Silica 1.0g, BHT 0.05g, o-phenyl phenol 0.02g, heating stirring to being completely dissolved, make its into
Gel-type vehicle, cold bath are cooled to less than 40 DEG C；
3）Take 5.0g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）25.0g basic bismuth nitrates are added portionwise, every batch adds 2.5g, stirring while adding, adds the 25.0g alkali formula nitric acid
20min is persistently stirred after bismuth；50.0g basic bismuth nitrates are added portionwise again, add 2.5g every time, it is stirring while adding, held after adding
Continuous stirring 20min；The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 4
1）Basic bismuth nitrate and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 28.93g atoleines to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add aluminum stearate 2.5g, two
Silica 1.0g, BHT 0.05g, o-phenyl phenol 0.02g, heating stirring to being completely dissolved, make its into
Gel-type vehicle, cold bath are cooled to less than 40 DEG C；
3）Take 2.5g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）20.0g basic bismuth nitrates are added portionwise, every batch adds 2.0g, stirring while adding, adds the 20.0g alkali formula nitric acid
20min is persistently stirred after bismuth；45.0g basic bismuth nitrates are added portionwise again, add 2.0g every time, it is stirring while adding, held after adding
Continuous stirring 20min；The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 5
1）Basic bismuth nitrate and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 23.93g atoleines to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add aluminum stearate 2.5g, two
Silica 1.0g, BHT 0.05g, o-phenyl phenol 0.02g, heating stirring to being completely dissolved, make its into
Gel-type vehicle, cold bath are cooled to less than 40 DEG C；
3）Take 7.5g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）20.0g basic bismuth nitrates are added portionwise, every batch adds 2.0g, stirring while adding, adds the 20.0g alkali formula nitric acid
20min is persistently stirred after bismuth；45.0g basic bismuth nitrates are added portionwise again, add 2.0g every time, it is stirring while adding, held after adding
Continuous stirring 20min；The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 6
1）Titanium dioxide and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 26.43g fractionated coconut oils to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add aluminum monostearate
2.5g, lanolin 1.0g, 2,6- butylhydroxy anisoles 0.05g, potassium sorbate 0.02g, heating stirring make to being completely dissolved
, into gel-type vehicle, cold bath is cooled to less than 40 DEG C for it；
3）Take 5.0g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）20.0g titanium dioxide is added portionwise, every batch adds 2.0g, stirring while adding, after adding the 20.0g titanium dioxide
Persistently stir 20min；45.0g titanium dioxide is added portionwise again, adds 2.0g every time, it is stirring while adding, persistently stirred after adding
20min；The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 7
1）Zinc oxide and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 26.43g injection soybean oils to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add double stearic acid aluminium
2.5g, vaseline 1.0g, propylgallate 0.05g, methyl hydroxybenzoate 0.02g, heating stirring make its Cheng Ning to being completely dissolved
Gel matrix, cold bath are cooled to less than 40 DEG C；
3）Take 5.0g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）20.0g zinc oxide is added portionwise, every batch adds 2.0g, stirring while adding, continues after adding the 20.0g zinc oxide
Stir 20min；45.0g zinc oxide is added portionwise again, adds 2.0g every time, it is stirring while adding, 20min is persistently stirred after adding；
The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Embodiment 8
1）Barium sulfate and Gardenoside are subjected to micro mist processing respectively, are not more than 25 microns to particle diameter（μm）；
2）Take 26.43g ethyl oleates to be put into 250ml beakers, be warming up to 140 DEG C, sequentially add carbomer 2.5g, beeswax
1.0g, BHT 0.05g, benzoic acid 0.02g, heating stirring makes it into gel-type vehicle to being completely dissolved, cold
Water-bath is cooled to less than 40 DEG C；
3）Take 5.0g steps 1）Gardenoside after micro mist processing is placed in gel-type vehicle, ultrasonic disperse, and in high shear
The even 10min of scattered dispersing emulsification machine breast；
4）20.0g barium sulfate is added portionwise, every batch adds 2.0g, stirring while adding, continues after adding the 20.0g barium sulfate
Stir 20min；45.0g barium sulfate is added portionwise again, adds 2.0g every time, it is stirring while adding, 20min is persistently stirred after adding；
The finally even 30min of breast in high-shearing dispersion emulsifying machine；
5）Granularity is checked, is met the requirements（Particle diameter>25 μm of particle is no more than 10%）, produce described preventing and treating dry milk phase milk
The nipple sealer of garget, it is filling by every 4g, it is sealed, obtains the nipple for preventing milk cow dry breast phase mammitis and seal
Close agent finished product.
Clinical test of pesticide effectiveness research
1. material
1.1 trial drug
Control group：Gardenoside is replaced with into cloxacillin benzathine, is formulated by the technique of specific embodiment 1.
Test group：It is formulated by specific embodiment 1.
1.2 experimental animal
Choose certain large-scale milk cattle cultivating factory clinic mastitis natural occurrence case and amount to 60.
The experiment packet of table 1
2. test method
2.1 dosage regimen：It is administered after dairy cattle during nonlactating last time is milked after cleaning, sterilization nipple, each newborn area's nipple
Hole injection testing medicine.
2.1 index of assessment of curative effect
2.1.1 cure constitutional symptom to disappear, appetite recovers normal；The symptoms such as ill breast district is red, swollen, hot, pain disappear completely
Lose；
2.1.2 effective constitutional symptom disappears substantially, and appetite recovers normal；The symptoms such as ill breast district is red, swollen, hot, pain are bright
It is aobvious to improve or mitigate；
2.1.3 invalid constitutional symptom does not disappear or even aggravated；Ill breast district symptom is not improved or even aggravated.
2.2 daily yieldings and somatic number（SCC）Monitoring
To the average daily milk production and somatic number after healing milk cow calving in 1 week（SCC）It is monitored.
3. clinical effect trial result
The clinical effect trial result of table 2
4. the output of milk and milk composition monitoring
Table 3 cures milk cow average daily milk production measurement result
Table 4 cures the average somatic number measurement result of dairy cow milk
5. conclusion (of pressure testing)
Above-mentioned result of the test shows, the nipple sealer of the invention containing Gardenoside, compared with adding antibiotic control group, energy
The cure rate of milk cow dry breast phase mammitis is enough significantly improved, effectively alleviates the inflammatory reaction of clinic mastitis；Somatic number
（SCC）Be weigh milk in the important indicator of pathogenic microorganism and bacterial endotoxin, somatic number is higher, illustrate in breast by
Immune response caused by pathogenic bacteria and endotoxin is stronger, and be averaged somatic number result after calving in 1 week in milk
As can be seen that the nipple sealer of the present invention, can effectively reduce the somatic number in milk, for being drawn by bacterial endotoxin
The clinic mastitis risen have good therapeutic action, are a kind of preferably nipple envelopes for the preventing and treating of milk cow dry breast phase mammitis
Close agent medicine.
Claims (7)
- A kind of 1. nipple sealer for being used to prevent milk cow dry breast phase mammitis, it is characterised in that：By 40wt%-75 wt% nothing The gel-type vehicle composition of noxious metals compound, 2 wt %-10 wt % Gardenoside and 10 wt %-50 wt %；It is wherein described Gel-type vehicle is helped by 70 wt %-90 wt % decentralized medium, 5 wt %-12 wt % gel, 2 wt %-5 wt % The preservative composition of suspension, 0.1wt %-0.3 wt % antioxidant and 0.04 wt %-0.15 wt %；The decentralized medium is Atoleine, fractionated coconut oil, injection soybean oil, medium-chain fatty acid glyceride, one kind in ethyl oleate or its combination； The gel is one kind in aluminum monostearate, aluminum stearate, double stearic acid aluminium, magnesium stearate, rilanit special, carbomer Or its combination；The suspending agent is one in silica, lanolin, glycerin monostearate, vaseline, beeswax, emulsifying wax Kind or its combination；The antioxidant is DBPC 2,6 ditertiary butyl p cresol, butylhydroxy anisole, vitamin E, gallic acid third One kind or its combination in ester；The preservative is methyl hydroxybenzoate, propylben, benzoic acid, potassium sorbate, adjacent phenyl benzene One kind or its combination in phenol；The nontoxic metal compound is in basic bismuth nitrate, titanium dioxide, zinc oxide, barium sulfate At least one.
- 2. it is used for the nipple sealer for preventing milk cow dry breast phase mammitis as claimed in claim 1, it is characterised in that：By 55wt%- The gel-type vehicle composition of 65 wt% nontoxic metal compound, 4wt %-6 wt % Gardenoside and 25wt %-35wt %.
- 3. it is used for the nipple sealer for preventing milk cow dry breast phase mammitis as claimed in claim 2, it is characterised in that：By 60wt% Nontoxic metal compound, 5wt % Gardenoside and 30wt % gel-type vehicle composition.
- 4. being used for the preparation method for preventing the nipple sealer of milk cow dry breast phase mammitis as claimed in claim 1, its feature exists In concretely comprising the following steps：1）The nontoxic metal compound and Gardenoside are subjected to micro mist processing respectively, are 10-40 μm to particle diameter；2）Gel, suspending agent, antioxidant, preservative are dispersed in decentralized medium, obtain gel-type vehicle；3）By step 1）Gardenoside after micro mist processing is dispersed in the gel-type vehicle；4）The nontoxic metal compound of 1/3 recipe quantity is added portionwise, it is stirring while adding, add the nontoxic of 1/3 recipe quantity 10-30min is persistently stirred after metallic compound；The nontoxic metal compound of remaining 2/3 recipe quantity is added portionwise, held after adding Continuous stirring 10-30min；Finally breast is even in high-shearing dispersion emulsifying machine；5）Dispense and seal, obtain the nipple sealer finished product for preventing milk cow dry breast phase mammitis.
- 5. the preparation method of nipple sealer as claimed in claim 4, it is characterised in that：Step 1）It is middle to use jet mill Carry out micro mist processing.
- 6. the preparation method of nipple sealer as claimed in claim 5, it is characterised in that：Step 1）Middle micro mist, which is handled to particle diameter, is 10-25μm。
- 7. the preparation method of nipple sealer as claimed in claim 4, it is characterised in that：Step 2）Described in dispersed use Disperse under ultrasonic disperse or heating condition.
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| EP3634378A1 (en) * | 2017-06-09 | 2020-04-15 | Zoetis Broomhill IP Limited | Intramammary veterinary composition |
| CN112516226A (en) * | 2020-12-11 | 2021-03-19 | 齐鲁动物保健品有限公司 | Breast injectant for preventing mastitis of dairy cows in dry period and preparation method thereof |
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