CN107308104A - A kind of preparation method of gynecological gel - Google Patents
A kind of preparation method of gynecological gel Download PDFInfo
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- CN107308104A CN107308104A CN201710524860.9A CN201710524860A CN107308104A CN 107308104 A CN107308104 A CN 107308104A CN 201710524860 A CN201710524860 A CN 201710524860A CN 107308104 A CN107308104 A CN 107308104A
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- China
- Prior art keywords
- alkannin
- gel
- glycerine
- preservative
- dipotassium glycyrrhizinate
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- 238000002360 preparation method Methods 0.000 title claims abstract description 11
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 40
- 238000003756 stirring Methods 0.000 claims abstract description 22
- NEZONWMXZKDMKF-JTQLQIEISA-N Alkannin Chemical compound C1=CC(O)=C2C(=O)C([C@@H](O)CC=C(C)C)=CC(=O)C2=C1O NEZONWMXZKDMKF-JTQLQIEISA-N 0.000 claims abstract description 20
- 239000004229 Alkannin Substances 0.000 claims abstract description 20
- UNNKKUDWEASWDN-UHFFFAOYSA-N alkannin Natural products CC(=CCC(O)c1cc(O)c2C(=O)C=CC(=O)c2c1O)C UNNKKUDWEASWDN-UHFFFAOYSA-N 0.000 claims abstract description 20
- 235000019232 alkannin Nutrition 0.000 claims abstract description 20
- 235000011187 glycerol Nutrition 0.000 claims abstract description 20
- 239000008213 purified water Substances 0.000 claims abstract description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical class [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims abstract description 13
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims abstract description 13
- 229960000502 poloxamer Drugs 0.000 claims abstract description 13
- 229920001983 poloxamer Polymers 0.000 claims abstract description 13
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 claims abstract description 12
- 229920002125 Sokalan® Polymers 0.000 claims abstract description 12
- 229960001631 carbomer Drugs 0.000 claims abstract description 12
- 239000003755 preservative agent Substances 0.000 claims abstract description 12
- 230000002335 preservative effect Effects 0.000 claims abstract description 12
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 claims abstract description 9
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 claims abstract description 8
- 238000007599 discharging Methods 0.000 claims abstract description 8
- 238000011049 filling Methods 0.000 claims abstract description 8
- 239000002994 raw material Substances 0.000 claims abstract description 8
- 235000011837 pasties Nutrition 0.000 claims abstract description 7
- 238000010438 heat treatment Methods 0.000 claims abstract description 3
- 239000000203 mixture Substances 0.000 claims description 4
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 4
- NWAUTLQNAVHOME-UHFFFAOYSA-N ClC(C)O.C1=CC=CC=C1 Chemical compound ClC(C)O.C1=CC=CC=C1 NWAUTLQNAVHOME-UHFFFAOYSA-N 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 16
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 6
- 230000036039 immunity Effects 0.000 abstract description 6
- 230000001954 sterilising effect Effects 0.000 abstract description 6
- 238000004659 sterilization and disinfection Methods 0.000 abstract description 6
- 206010061218 Inflammation Diseases 0.000 abstract description 4
- 230000004054 inflammatory process Effects 0.000 abstract description 4
- 230000008439 repair process Effects 0.000 abstract description 3
- 230000036548 skin texture Effects 0.000 abstract description 3
- 230000003467 diminishing effect Effects 0.000 abstract description 2
- 230000023597 hemostasis Effects 0.000 abstract description 2
- 239000012466 permeate Substances 0.000 abstract description 2
- 230000019522 cellular metabolic process Effects 0.000 abstract 1
- 230000008961 swelling Effects 0.000 description 13
- 210000001215 vagina Anatomy 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 8
- 201000010099 disease Diseases 0.000 description 6
- 238000004090 dissolution Methods 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 241000222122 Candida albicans Species 0.000 description 5
- 241000588724 Escherichia coli Species 0.000 description 5
- 230000000844 anti-bacterial effect Effects 0.000 description 5
- 229940095731 candida albicans Drugs 0.000 description 5
- 239000003795 chemical substances by application Substances 0.000 description 5
- 239000003814 drug Substances 0.000 description 5
- VTAJIXDZFCRWBR-UHFFFAOYSA-N Licoricesaponin B2 Natural products C1C(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2)C(O)=O)C)(C)CC2)(C)C2C(C)(C)CC1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O VTAJIXDZFCRWBR-UHFFFAOYSA-N 0.000 description 4
- LPLVUJXQOOQHMX-UHFFFAOYSA-N glycyrrhetinic acid glycoside Natural products C1CC(C2C(C3(CCC4(C)CCC(C)(CC4C3=CC2=O)C(O)=O)C)(C)CC2)(C)C2C(C)(C)C1OC1OC(C(O)=O)C(O)C(O)C1OC1OC(C(O)=O)C(O)C(O)C1O LPLVUJXQOOQHMX-UHFFFAOYSA-N 0.000 description 4
- 229960004949 glycyrrhizic acid Drugs 0.000 description 4
- UYRUBYNTXSDKQT-UHFFFAOYSA-N glycyrrhizic acid Natural products CC1(C)C(CCC2(C)C1CCC3(C)C2C(=O)C=C4C5CC(C)(CCC5(C)CCC34C)C(=O)O)OC6OC(C(O)C(O)C6OC7OC(O)C(O)C(O)C7C(=O)O)C(=O)O UYRUBYNTXSDKQT-UHFFFAOYSA-N 0.000 description 4
- 239000001685 glycyrrhizic acid Substances 0.000 description 4
- 235000019410 glycyrrhizin Nutrition 0.000 description 4
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 4
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 239000000047 product Substances 0.000 description 3
- 208000024891 symptom Diseases 0.000 description 3
- 208000004926 Bacterial Vaginosis Diseases 0.000 description 2
- 235000004256 Buglossoides arvense Nutrition 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 2
- 241000118841 Lithospermum incisum Species 0.000 description 2
- 230000003266 anti-allergic effect Effects 0.000 description 2
- 239000003899 bactericide agent Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 208000035475 disorder Diseases 0.000 description 2
- 239000012530 fluid Substances 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000027939 micturition Effects 0.000 description 2
- 239000003002 pH adjusting agent Substances 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 230000002265 prevention Effects 0.000 description 2
- 238000011321 prophylaxis Methods 0.000 description 2
- 230000005186 women's health Effects 0.000 description 2
- KETQAJRQOHHATG-UHFFFAOYSA-N 1,2-naphthoquinone Chemical class C1=CC=C2C(=O)C(=O)C=CC2=C1 KETQAJRQOHHATG-UHFFFAOYSA-N 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241000606161 Chlamydia Species 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 206010020565 Hyperaemia Diseases 0.000 description 1
- 241000204031 Mycoplasma Species 0.000 description 1
- WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 description 1
- -1 Propane diols Chemical class 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 241001502500 Trichomonadida Species 0.000 description 1
- 241000224526 Trichomonas Species 0.000 description 1
- 206010046914 Vaginal infection Diseases 0.000 description 1
- 201000008100 Vaginitis Diseases 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 230000000845 anti-microbial effect Effects 0.000 description 1
- 230000003064 anti-oxidating effect Effects 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 238000004140 cleaning Methods 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N dimethylmethane Natural products CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 1
- 239000007938 effervescent tablet Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- 210000002615 epidermis Anatomy 0.000 description 1
- 238000001879 gelation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 230000004060 metabolic process Effects 0.000 description 1
- 244000000010 microbial pathogen Species 0.000 description 1
- 238000000386 microscopy Methods 0.000 description 1
- 210000004877 mucosa Anatomy 0.000 description 1
- 239000013642 negative control Substances 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 239000000049 pigment Substances 0.000 description 1
- 239000001103 potassium chloride Substances 0.000 description 1
- 235000011164 potassium chloride Nutrition 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 238000004080 punching Methods 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 210000005000 reproductive tract Anatomy 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 230000036560 skin regeneration Effects 0.000 description 1
- 239000007901 soft capsule Substances 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 239000007921 spray Substances 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000013589 supplement Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 241001148471 unidentified anaerobic bacterium Species 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
- A61K31/122—Ketones having the oxygen directly attached to a ring, e.g. quinones, vitamin K1, anthralin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
- A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
- A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Molecular Biology (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of preparation method of gynecological gel.Gel is formulated by weight by following raw material:Alkannin 0.01~0.05%, dipotassium glycyrrhizinate salt 0.1~0.5%, poloxamer 2~12%, glycerine 8~25%, propane diols 0.1~5%, preservative 0.05~0.5%, carbomer 0.1~0.5%, purified water 56~89.64%.Specific preparation method of the invention is as follows：(1) weigh carbomer by proportion and add glycerine, stirring is allowed into pasty state；(2) poloxamer, glycerine, alkannin, dipotassium glycyrrhizinate salt, purified water, 85 DEG C of heating stirring dissolvings of preservative are added；(3) triethanolamine is added dropwise, to PH5.0~6.0, stops stirring, discharging is filling.The Chinese medical extract alkannin that the present invention is added acts synergistically with dipotassium glycyrrhizinate salt, with anti-inflammatory, hemostasis, promotes effect of cell metabolism, can rapidly permeate into skin, repairs skin texture, reaches sterilization, the effect for improving immunity, diminishing inflammation.
Description
Technical field
The present invention relates to gynecologic medicine field, and more particularly to a kind of preparation method of gynecological gel.
Background technology
Women's health turns into the topic that everybody discusses warmly in recent years, and research shows that RTI has become women's health
Potential threat, privates courses of infection can cause the generation of various gynecological diseases, trigger one of root of RTI to be each
Kind easily hide in the conditioned pathogen of inside and outside private parts, such as staphylococcus, streptococcus, Escherichia coli, anaerobic bacteria, spread through sex intercourse cause of disease
Body, Candida albicans and mycoplasma, Chlamydia etc..
From product characteristics, at present on the market gynaecology act on reproduction tract drug have effervescent tablet class, soft capsule class, punching
Class, suppository class, spray class etc. are washed, action time is short, taken effect relatively slow；From product function, existing gyniatrics class
Medicine adds substantial amounts of wide-spectrum bactericide, suppress gold-coloured staphylococci, Escherichia coli, Candida albicans etc. " harmful bacteria " and
While pathogenic microorganisms, " beneficial bacterium " Bacillus acidi lactici can be also killed, is destroyed under the stabilization of intravaginal flora, immunity of organisms
Drop, causes pathogenic bacteria to develop immunity to drugs and drug resistance, inflammation recurrent exerbation.
In existing patent documentation data storehouse, No. 201610701304.X《A kind of gynecological gel》And No. 200910309483.2
《It is a kind of to treat gel of gynaecological imflammation and preparation method thereof》Material combination is various, and antibacterial, anti-inflammatory effect is unknown,
201610701304.X number《Gynecological gel and preparation method thereof》It is the antimicrobial compositions of activated carbon and silver, contained suppression
Bacterium composition can all destroy the colony balance of vagina, decline vagina resistance, influence genital tract health.
Alkannin is a kind of naphthalene quinones substance extracted from Asian puccoon, and the peculiar natural anti-inflammatory of Asian puccoon, epidermis reparation are lived
Property composition, and have certain antibacterial, antioxidation activity, using safety, effect is good.With anti-inflammatory, hemostasis, promote skin regeneration, carefully
Effect of born of the same parents' metabolism, can rapidly permeate into skin, repair skin texture, reach sterilization, diminish inflammation, improve immunity of organisms and pre-
Effect of anti-gynecological disease.
Dipotassium glycyrrhizinate salt, which is that effective component extracting is refined from radix glycyrrhizae, to be formed, antibacterial containing with strengthen immunity,
Sterilization, a variety of physiologically active ingredients of antiallergy effect.With alkannin collective effect, sterilization, effect of antiallergic reparation are enhanced.
Advantage of the invention is that：
（1）This product with the addition of alkannin, dipotassium glycyrrhizinate salt, the enhancing of inhibiting bacteria and diminishing inflammation function, and side effect is not present to human body,
It is made after gel and is easier to be absorbed by the body, improves the curative effect of medicine.
（2）Without rinsing when using, the purpose that prevention is cured the disease can be played by being detained in intravaginal, and its effective acting time can
To maintain more than 12 hours, then it can be naturally drained with vaginal fluid in vitro, due to itself pale red（The face of alkannin
Color）, can be discovered during discharge.
（3）Gynecological gel is glutinous thick liquid, is difficult outflow, can be distributed in well among vagina again.
（4）Gynecological gel, the aobvious acidity of pH, for maintaining the normal sour environment of intravaginal, can suppress some pathogen
Growth, strengthen vagina immunocompetence.
（5）Poloxamer is added, is protected " beneficial bacterium ", the balance of flora inside vagina is maintained.
The content of the invention
It is an object of the invention to develop a kind of gynecological gel, for vagina cleaning, nursing, sterilization, anti-inflammatory, repair
Multiple skin texture, prevention gynaecology relevant disease, improves immunity of organisms, so as to reach the protective effect to women privates.
To achieve these goals, the invention provides the woman that the preparation method of gynecological gel, the preparation method are prepared
Section's gel viscosity is moderate, alkannin, the addition of radix glycyrrhizae, enhances sterilization, effect of anti-inflammatory prophylaxis of gynaecological disorders；In addition, pool Lip river
Husky nurse can protect profitable strain, prevent because arriving internal flora imbalance, prophylaxis of gynaecological disorders.
The present invention is solved its technical problem and realized using following technical scheme：
A kind of gynecological gel, alkannin 0.01~0.05%, preferably 0.03%；Dipotassium glycyrrhizinate salt 0.1~0.5%, be preferably
0.2%；Poloxamer 2~12%, preferably 4%；Glycerine 8~25%, preferably 20%；Propane diols 0.1~5%, preferably 3%；It is anti-
Rotten agent 0.05~0.5%, preferably 0.29%；Carbomer 0.1~0.5%, preferably 0.3%；Purified water 56~89.64%.
A kind of preparation method of gynecological gel：
（1）Weigh carbomer and add glycerine, stir into pasty state；
（2）Poloxamer, bactericide, glycerine, dipotassium glycyrrhizinate salt, transparent xanthan gum, preservative, propane diols is added to be made
Bright swelling solution, after swelling solution is cooled to room temperature, adds after alkannin and pigment, ultrasonic dissolution into swelling solution and stirs equal
It is even；
（3）Be added dropwise triethanolamine, it is stirring while adding to uniform, supplement purified water constant volume, after stir；
（4）Stop stirring, discharging；It is filling.
Embodiment
The present invention is made with reference to specific embodiment further to explain.
Raw material sources explanation：Alkannin, dipotassium glycyrrhizinate salt by Jiangsu Nai Que biotechnologies Co., Ltd inside
Personnel extract gained.
Embodiment 1
（1）Each raw material is weighed by mass percentage；
（2）Carbomer 0.3% is added into appropriate glycerine, heating stirring is allowed to dissolve；Add poloxamer 4%, glycerine 20%,
Transparent swelling solution is made in dipotassium glycyrrhizinate salt 0.2%, preservative 0.29%, propane diols 3%, Purified Water q. s；
（3）It is cooled to after room temperature, is stirred after adding alkannin 0.03%, ultrasonic dissolution；
（4）Triethanolamine is being slowly added dropwise into swelling solution（10%）5.5%, plus purified water constant volume, stir；
（5）Stop stirring, discharging；It is filling.
Embodiment 2
（1）Each raw material is weighed by mass percentage；
（2）Carbomer 0.1% is added into appropriate glycerine, pasty state is stirred into；Add poloxamer 2%, glycerine 8%, glycyrrhizic acid two
Transparent swelling solution is made in sylvite 0.1%, preservative 0.05%, propane diols 4%, Purified Water q. s；
（3）It is cooled to after room temperature, is stirred after adding alkannin 0.04%, ultrasonic dissolution；
（4）PH adjusting agent triethanolamine is being slowly added dropwise into swelling solution（10%）4%, plus purified water constant volume, stir；
（5）Stop stirring, discharging；It is filling.
Embodiment 3
（1）Each raw material is weighed by mass percentage；
（2）Carbomer 0.5% is added into appropriate glycerine, pasty state is stirred into；Add poloxamer 10%, glycerine 25%, glycyrrhizic acid
Transparent swelling solution is made in di-potassium 0.5%, preservative 0.5%, propane diols 5%, Purified Water q. s；
（3）It is cooled to after room temperature, is stirred after adding alkannin 0.05%, ultrasonic dissolution；
（4）PH adjusting agent triethanolamine is being slowly added dropwise into swelling solution（10%）8%, plus purified water constant volume, stir；
（5）Stop stirring, discharging；It is filling.
Embodiment 4
（1）Each raw material is weighed by mass percentage；
（2）Carbomer 0.2% is added into appropriate glycerine, pasty state is stirred into；Add poloxamer 5%, glycerine 10%, glycyrrhizic acid
Transparent swelling solution is made in di-potassium 0.4%, preservative 0.35%, propane diols 1%, Purified Water q. s；
（3）It is cooled to after room temperature, is stirred after adding alkannin 0.01%, ultrasonic dissolution；
（4）Triethanolamine is being slowly added dropwise into swelling solution（10%）5%, plus purified water constant volume stirs；
（5）Stop stirring, discharging；It is filling.
Embodiment 5
（1）Each raw material is weighed by mass percentage；
（2）Carbomer 0.4% is added into appropriate glycerine, pasty state is stirred into；Add poloxamer 6%, glycerine 15%, glycyrrhizic acid
Di-potassium 0.3%, preservative 0.4%, propane diols 2%, Purified Water q. s transparent swelling solution is made；
（3）It is cooled to after room temperature, is stirred after adding alkannin 0.02%, ultrasonic dissolution；
（4）Triethanolamine is being slowly added dropwise into swelling solution（10%）8%, plus purified water constant volume stirs；
（5）Stop stirring, discharging；It is filling.
Embodiment 6
（1）The bacteriostatic test and data of inventive gel agent：
（2）Gel prepared by embodiment 1-5 to staphylococcus aureus, Escherichia coli, Candida albicans carry out 2,5,10,
The effect of 20 minutes, as a result such as table 1
Table 1
Negative control：Culture medium has seldom bacterium colony.
As a result show inventive gel agent to staphylococcus aureus, Escherichia coli, Candida albicans average bacteriostasis rate
For 90%.
Embodiment 7：
Inventive gel agent is to human clinical trial's data：
Case selection：Patient 760, wherein age 20-55 Sui, the people of bacterial vaginitis 285, the people of colpomycosis 270, drop
The people of worm property vaginitis 205.
Cardinal symptom：Leucorrhea increasing, pruritus vulvue pain can be with frequent micturition, urgent urination or intercourse pain, visible vulva during inspection
And vagina mucosa goes out hyperemia.Distinguish visible trichomonad or fungi during trichomonas or colpomycosis patient's vaginal fluid microscopy,
Bacterial vaginitis BV is checked and is positive.
The embodiment 1-5 specifically used method of gel is：Use 2 times daily, 5 grams every time, be applied directly to vagina.
Control group is cloudy using clean that, application method：2 times a day, every time 10 milliliters, vagina cleaner is used.
Outcome measure：
Recovery from illness：Subjective symptoms is disappeared, and vagina cleanness degree (I), vaginal swab culture is turned out cloudy；
Effectively：Subjective symptoms mitigates, and vagina cleanness degree (II), vaginal swab culture only has a small number of mycelial growths, is no more than
10；
It is invalid：Feel normally without improvement, vagina cleanness degree is unchanged, and vaginal swab culture is unchanged.
Curative effect is shown in Table 2
Table 2
In summary, gynecological gel of the present invention have to staphylococcus aureus, Escherichia coli, Candida albicans preferably suppress and
Insect killing effect, has good curative effect on treatment gynecological disease.
It can be seen that from the average inhibition and human clinical trial's data comparison for acting on different strain different time：This
Invention gynecological gel optimal components proportioning is carbomer 0.3%, poloxamer 4%, glycerine 20%, dipotassium glycyrrhizinate salt 0.2%, anti-corrosion
Agent 0.29%, propane diols 3%, alkannin 0.03%, remaining component are purified water.
Claims (5)
1. a kind of gynecological gel, it is characterised in that gel is formulated by weight by following raw material：Alkannin 0.01~
0.05%th, dipotassium glycyrrhizinate salt 0.1~0.5%, poloxamer 2~12%, glycerine 8~25%, propane diols 0. 1~5%, preservative
0.05~0.5%, carbomer 0.1~0.5%, purified water 56~89.64%.
2. a kind of gynecological gel, it is characterised in that preparation method is comprised the steps of：
（1）Carbomer is weighed by proportion and adds glycerine, and stirring is allowed into pasty state；
（2）Add poloxamer, glycerine, alkannin, dipotassium glycyrrhizinate salt, purified water, 85 DEG C of heating stirring dissolvings of preservative；
（3）Triethanolamine is added dropwise, to PH5.0~6.0, stops stirring, discharging is filling.
3. gel according to claim 1, it is characterised in that described alkannin purity is more than 80%.
4. gel according to claim 1, it is characterised in that the purity of described dipotassium glycyrrhizinate salt is more than 70%.
5. preservative according to claim 1, it is characterised in that preservative can be Nipasol, oxybenzene formicester, oxybenzene
One kind in second fat, benzene chlorethanol, or two or more mixtures.
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