CN1045719C - Oral liquid for setting bone and treating osteoporosis - Google Patents
Oral liquid for setting bone and treating osteoporosis Download PDFInfo
- Publication number
- CN1045719C CN1045719C CN93103742A CN93103742A CN1045719C CN 1045719 C CN1045719 C CN 1045719C CN 93103742 A CN93103742 A CN 93103742A CN 93103742 A CN93103742 A CN 93103742A CN 1045719 C CN1045719 C CN 1045719C
- Authority
- CN
- China
- Prior art keywords
- treating osteoporosis
- oral liquid
- oral
- weight
- setting bone
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 208000001132 Osteoporosis Diseases 0.000 title claims abstract description 10
- 239000007788 liquid Substances 0.000 title claims abstract description 8
- 210000000988 bone and bone Anatomy 0.000 title abstract description 3
- 102000008186 Collagen Human genes 0.000 claims abstract description 15
- 108010035532 Collagen Proteins 0.000 claims abstract description 15
- 229920001436 collagen Polymers 0.000 claims abstract description 7
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000003814 drug Substances 0.000 abstract description 8
- 230000000694 effects Effects 0.000 abstract description 6
- 238000009940 knitting Methods 0.000 abstract description 2
- 235000012907 honey Nutrition 0.000 abstract 1
- 230000007062 hydrolysis Effects 0.000 abstract 1
- 238000006460 hydrolysis reaction Methods 0.000 abstract 1
- 239000000706 filtrate Substances 0.000 description 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 4
- 230000000052 comparative effect Effects 0.000 description 4
- 238000003307 slaughter Methods 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 3
- 206010039984 Senile osteoporosis Diseases 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 230000035617 depilation Effects 0.000 description 3
- 235000008733 Citrus aurantifolia Nutrition 0.000 description 2
- 108010010803 Gelatin Proteins 0.000 description 2
- 235000011941 Tilia x europaea Nutrition 0.000 description 2
- 239000006071 cream Substances 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 239000000284 extract Substances 0.000 description 2
- 229920000159 gelatin Polymers 0.000 description 2
- 239000008273 gelatin Substances 0.000 description 2
- 235000019322 gelatine Nutrition 0.000 description 2
- 235000011852 gelatine desserts Nutrition 0.000 description 2
- 208000015181 infectious disease Diseases 0.000 description 2
- 239000004571 lime Substances 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 238000012856 packing Methods 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 241000700198 Cavia Species 0.000 description 1
- 241000700199 Cavia porcellus Species 0.000 description 1
- 102000057297 Pepsin A Human genes 0.000 description 1
- 108090000284 Pepsin A Proteins 0.000 description 1
- 101710137908 Pepsin-2 Proteins 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 239000002775 capsule Substances 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 238000002594 fluoroscopy Methods 0.000 description 1
- 230000008014 freezing Effects 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 239000003292 glue Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000010985 leather Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 229940111202 pepsin Drugs 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The oral medicine for setting bone and treating osteoporosis is prepared with active collagen and honey and through killing, peeling and hydrolysis, and has obvious effect of treating osteoporosis. Is the latest generation of oral bone-knitting liquid at present.
Description
The present invention relates to a kind of active collagen as synthetism with control the oral liquid that osteoporosis is used, particularly a kind ofly become active collagen as synthetism with control the oral medicine that osteoporosis is used the fresh calf leather.
As everyone knows, collagen protein (Collagen) is the usefulness as cosmetics and therapeutic medical capsule, gelatin blood plasma and the absorbefacient glue sponge of external.
The purpose of this invention is to provide a kind of up-to-date purposes, as the oral medicine that synthetism is used, its particular significant effect generally is that knochenbruch can all connect about 4 days to a week, does not produce to infect and the antibody phenomenon.
The present invention implements like this: get harsh calf-skin degrease layer and depilation of getting off, with 10% lime cream dipping, depilation cuts into pieces, and transfers pH to 2.0-2.5 with hydrochloric acid.Adding pepsin (its amount is a weight 0.1-0.25% after the Corii Bovis seu Bubali unhairing) was hydrolyzed 5-15 hours under 40-50 ℃ of stirrings, filter then, filtrate transfers to pH=7.0 with sodium hydroxide, filter,, refilter filtrate is added Mel (for filtrate 20% weight) 80-100 ℃ of filtrate heating totally 1 hour, dress 10ml oral liquid bottle, every is closed the 1g collagen protein, and 85-100 ℃ of sterilizations, packing forms again.
The following examples elaborate to the present invention, but do not limit the scope of the invention.
Example 1, get harsh down after slaughtering less than 5 hours and through the calf-skin 1kg of degrease layer and depilation, dipping is 2 days in 10% lime cream, swollen calf-skin is cut into pieces, transfer to pH=2.0-2.5 with 2N hydrochloric acid, add pepsin 2 grams, stirred 10 hours down at 47 ± 2 ℃, filter, filtrate is transferred pH to 7.0 with 2NNaOH solution, refilters filtrate reheat to 90 ± 2 ℃, get slightly milky translucent filtrate, by analysis filtrate to contain collagen protein be 12.5% weight, be diluted with water to that to contain collagen concentration be 10% weight, altogether the collagen protein 5kg of 10% concentration, add 1 kilogram of Mel, mix homogeneously is packed this mixed liquor in the 10ml oral liquid bottle into, again 85-100 ℃ of sterilization down, the packing oral bone knitting liquid of the present invention, carry out animal synthetism clinical trial then.See Table 1 and the senile osteoporosis clinical trial.
Comparative example 1 replaces the calf-skin of example 1 except that getting the harsh calf-skin that gets off through slaughtering after carrying out freezing 1 week immediately; All the other conditions are identical with example 1, make same concentration oral liquid, carry out the animal clinical trial then.See Table 1 and the senile osteoporosis clinical trial.
Comparative example 2 with 0.5 kilogram in commercially available gelatin, is mixed with 10% collagen protein with warm water dissolving and adds 20% Mel and form, and equally also carries out the animal clinical trial, sees Table 1.
Zooperal method is; Get 200 of guinea pigs, total man worker interrupts lower limb, does contrast for 100 and does not take medicine, feed for twice 100 every days, and each 2ml, its situation of observation after 4 days and 30 days:
Table 1 guinea pig synthetism clinical trial
| Do not take medicine | Take medicine | |||
| 4 days | Do not connect | Example 1 all connects | It is 20% undesirable that comparative example 1 80% connects | Comparative example 2 does not connect |
| 30 days | 70% infection 10% connects undesirable 20% and connects | 95% connect 5% undesirable | 65% infection 15% connects undesirable 20% and connects | |
Can learn from last table:
1. will get and harshly get off, extract collagen protein after slaughtering immediately, just have activity, the synthetism effect is also good, extracts collagen protein after slaughtering a week, and active decline is so its synthetism curative effect is relatively poor.
2. general collagen protein is of no curative effect, and does not take medicine much at one.
The clinical trial of senile osteoporosis is: oral, and every day twice, each 2, every 10ml, x-ray fluoroscopy after month is observed its situation, and the result is that full recovery is normal.
Advantage of the present invention:
1. method for making is simple, and synthetism is effective.
2. also effective in cure to osteoporosis.
Claims (1)
1. Orally taken fracture setting and osteoporosis treating liquid is characterized in that:
Be that content is 10% weight by the active collagen of (1) the harsh new calf-skin preparation of killing of getting off;
(2) Mel, content are 20% weight; With
(3) water, content are that 70% weight is made.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93103742A CN1045719C (en) | 1993-04-10 | 1993-04-10 | Oral liquid for setting bone and treating osteoporosis |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93103742A CN1045719C (en) | 1993-04-10 | 1993-04-10 | Oral liquid for setting bone and treating osteoporosis |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1077630A CN1077630A (en) | 1993-10-27 |
| CN1045719C true CN1045719C (en) | 1999-10-20 |
Family
ID=4984756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93103742A Expired - Fee Related CN1045719C (en) | 1993-04-10 | 1993-04-10 | Oral liquid for setting bone and treating osteoporosis |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1045719C (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE282423T1 (en) * | 1994-08-23 | 2004-12-15 | Stoess & Co Gelatine | USE OF UNTASTED, HYDROLYZED COLLAGEN AND AGENTS CONTAINING THE SAME |
| JP4609807B2 (en) * | 1996-03-28 | 2011-01-12 | 雪印乳業株式会社 | Bone-strengthening medicine, food and drink, and feed |
| CN1070711C (en) * | 1996-12-18 | 2001-09-12 | 齐鲁制药厂 | Collagen oral preparation and preparing method thereof |
| GB2519072B (en) * | 2013-10-07 | 2019-12-04 | Welland Medical Ltd | Composition comprising collagen and honey |
| EP3656401A1 (en) * | 2014-08-05 | 2020-05-27 | The University of Memphis | Compositions and methods for enhancing healing and regeneration of bone and soft tissue |
| CN107454847A (en) | 2015-04-15 | 2017-12-08 | 韦兰医疗有限责任公司 | Composition comprising collagen and honey |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87102744A (en) * | 1986-08-05 | 1988-02-17 | 罗巴法姆股份公司 | Composition for stimulating chondrocytes and osteoblasts (collagen hydroxyapatite compound), method for preparing the same, and pharmaceutical product containing the same |
-
1993
- 1993-04-10 CN CN93103742A patent/CN1045719C/en not_active Expired - Fee Related
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN87102744A (en) * | 1986-08-05 | 1988-02-17 | 罗巴法姆股份公司 | Composition for stimulating chondrocytes and osteoblasts (collagen hydroxyapatite compound), method for preparing the same, and pharmaceutical product containing the same |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1077630A (en) | 1993-10-27 |
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