CN104524422A - Pill for treating gynecomastia and preparation method thereof - Google Patents

Abstract

The invention discloses a pill for treating gynecomastia and a preparation method thereof, and belongs to the field of traditional Chinese medicine. The pill comprises the raw materials of effective components: eucommia bark, radix dipsaci, semen cuscutae, white atractylodes rhizome, herba epimedii, fructus lycii, cortex cinnamomi, radix bupleuri, nutgrass galingale rhizome, pericarpium citri reticulatae, radix salviae miltiorrhizae, poria cocos, cortex moutan, rhizoma chuanxiong, radix paeoniae rubra, radix polygoni multiflori, rhizoma curcumae, cornua cervi pantotrichum, radix cyathulae, rhizoma alismatis, rhizoma pinellinae praeparata, tuber fleeceflower stem, bulbus fritillariae cirrhosae, licorice, pulp of cornus, and curculigo orchioides; the above medicines are processed in a certain way to prepare the pill product. The selected medicines meet the principle of different raw materials having different functions, drug properties are adapted and complemented with each other, the remedy is suited to the cases aiming at loss of nourishment of liver and kidney, blood and qi stagnation, liver qi depression and phlegm stasis, qi stagnation and blood stasis and other pathogenesis, and the pill has the effects of nourishing the liver and kidney, smoothing liver and resolving depression, and promoting blood circulation to remove meridian obstruction, has the advantages of good absorption effect, obvious curative effect, no toxic or side effect and no clinical adverse reactions, and has relatively high cure rate on gynecomastia through clinical verification.

Description

Pill for treating gynecomastia and preparation method thereof

Technical field

The invention relates to the field of traditional Chinese medicines, in particular to a pill for treating gynecomastia and a preparation method thereof.

Background technique

Gynecomastia is a common clinical disease, which refers to the phenomenon of unilateral or bilateral breast enlargement of male breasts after puberty or adulthood, flat round lumps appear under the areola, or even female breasts, accompanied by distending pain. Clinical also known as gynecomastia. The disease can occur after adolescence and adulthood, but it is more common in middle-aged and elderly people. As the age of puberty advances, children around 10 years old are also seen clinically. The disease is a benign breast stromal and ductal hyperplasia, and there are cases of self-regression.

Modern medicine thinks that the pathogenesis of this disease is still uncertain, and it is generally believed that it is related to endocrine disorders. Testicular dysplasia or inflammation, damage, or tumors of the testes can lead to decreased androgen secretion. The abnormality of liver function can lead to obstacles in the inactivation of estrogen, both of which can make the level of estrogen in the body relatively increased, thus leading to the development of breast tissue and abnormal hyperplasia. In addition, long-term estrogen therapy due to prostatic hypertrophy and prostate cancer, as well as long-term use of digitalis, reserpine, isoniazid, and isoniazid, can cause male breast hypertrophy.

Western medical treatment currently has drug therapy and surgical treatment to adjust estrogen levels. The operation is generally performed under local anesthesia. The general operation includes a transverse incision through the edge of the areola, the nipple, the areola, and an "L"-shaped incision on the areola and the outside of the breast to remove the breast tissue and part of the skin. Postoperative drainage, pressurized bandage, antibiotics for 7 days to prevent infection; in addition to surgery, dihydrotestosterone heptanoate, tamoxifen, clomiphene, testosterone lactone and other hormone drugs can also be used for treatment. However, it is easy to leave scars for surgical removal, which not only affects the appearance but also easily recurs. At present, it is mostly not used, except that the breast is too large, the pain is obvious, and it even causes the patient's mental anxiety; while taking hormone-adjusting drugs, it cannot be effective in the short term, and long-term use of hormone drugs is required, which will have a great impact on the patient. Side effects, so Western medicine is not ideal for the treatment of gynecomastia.

Traditional Chinese medicine believes that male breasts belong to the kidney, and nipples belong to the liver. If the emotions are not adjusted, the anger will hurt the liver, resulting in stagnation of liver qi, and stagnation for a long time will turn into fire, burn the body fluid of the liver and kidney, damage the liver function, and reduce the detoxification function. Too much estrogen cannot be inactivated in the liver, but acts on the target organ breast, or the elderly are weak, chronic illness affects the kidney, liver and kidney deficiency, kidney yin and yang deficiency, unable to conserve liver wood, wood qi is not relaxed, If the catharsis is neglected, the phlegm and dampness will stop gathering, and the upper milk collaterals can also cause this disease, or congenital evils can damage the liver, and liver failure can lead to lack of nourishment of the meridians, poor flow of qi and blood, resulting in blood stasis and phlegm coagulation, obstructed Stagnant meridians form gynecomastia. In short, the location of the disease is in the breast, and the dialectic involves the liver, spleen, and kidney; Dispersing stagnation, tonifying kidney and replenishing essence, etc.; clinically, it can be added or subtracted according to the symptoms. At present, there are few prescriptions for the treatment of gynecomastia in traditional Chinese medicine, most of which are based on soothing the liver and regulating qi, dredging the meridian and activating collaterals, which have certain curative effects, but the treatment cycle is longer and the effect is slow.

The pills described in the present invention mostly use liver and kidney to regulate the function between the hypothalamus---pituitary---testicular axis, restore liver function at the same time, strengthen the inactivation effect on excess estrogen, promote metabolism, and improve Qi Blood circulation can protect the liver and kidney, regulate endocrine reasonably, and keep the hormone level in the body relatively balanced. For the treatment of gynecomastia, it starts from the root of the disease, treats both symptoms and root causes, without the side effects of Western medicine hormone drugs, and the curative effect is also very significant.

Contents of the invention

The invention provides a pill for treating gynecomastia and a preparation method thereof, which has the effects of nourishing the liver and kidney, soothing the liver and relieving stagnation, resolving phlegm and dispelling stagnation, and treating both the root and the root of the disease, and treating gynecomastia caused by various causes. symptoms have good curative effect.

To achieve the above object, the technical solution of the present invention is implemented as follows:

A pill for treating gynecomastia, the composition and parts by weight of the active ingredients of the medicine are as follows:

The composition and parts by weight of raw materials for making the active ingredients of the drug are:

The composition and parts by weight of raw materials for making the active ingredients of the drug are:

A preparation method for a pill for treating gynecomastia, comprising the following process steps:

(1) Wash wolfberry, cornus, cinnamon, poria cocos, Moutan bark, Bupleurum chinensis, tangerine peel, Achyranthes bidentata, Pinellia chinensis, night cross vine, licorice, mix well after drying, and put them in a container. Add 6 to 8 times the amount of water in the container, heat and boil for 3 to 4 hours, take the infusion after cooling; add 4 to 6 times the amount of water to the remaining medicinal residues, heat and boil for 2 to 3 hours, after cooling Infusion solution; combine the two obtained infusion solutions, heat, evaporate and concentrate to a thick paste with a relative density of 1.10-1.20, and set aside;

(2) Put Polygonum multiflorum, Dipsacus, and Cuscuta into a container, add 3 to 5 times the amount of Shaoxing rice wine, boil and let cool, continue to soak for 3 to 4 hours, and take the infusion; add 2 ～3 times the amount of Shaoxing rice wine, boiled and let it dry, continue to soak for 2 to 3 hours, take the infusion; combine the two infusions, evaporate and concentrate to a thick paste with a relative density of 1.15 to 1.25, and set aside;

(3) Crush velvet antler, zedoary and fritillary fritillaria, grind them into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside;

(4) Put Atractylodes macrocephala, Rhizoma Chuanxiong, Radix Paeoniae Rubra, and curculigo in an iron pan, stir-fry over low heat until the skin turns yellow, sprinkle Jimo old wine, continue to stir-fry until the skin is brown, take it out and let it cool, grind it into powder, and over 120-mesh fine sieve to get fine powder, set aside;

(5) Wash and slice Cyperus cyperi, add a certain amount of rice vinegar, mix well, moisten until the vinegar is completely absorbed, put it in a frying container, heat it with a slow fire and fry it dry, take it out and let it cool. Sieve to remove debris, pulverize into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside;

(6) Take a certain amount of table salt and dissolve it in clear water, mix it evenly into the Eucommia medicinal material, heat it in a pot and stir-fry until dry, the surface color of the medicinal material is slightly darker, sieve off the debris, grind it into powder, pass through a 120-mesh fine sieve, Get fine powder, set aside;

(7) Heat and melt suet in a pot, then add fairy spleen, mix well and stir-fry until the suet is exhausted, the medicinal materials are crispy, sieve off debris, grind into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside ;

(8) Take Salvia miltiorrhiza and Alisma, wash and slice, dry in the sun, add Salvia miltiorrhiza and Alisma, stir-fry several times, spray with rice wine, fry dry, pulverize, pass through a 120-mesh fine sieve to obtain fine powder, and set aside;

(9) Combine the thick paste obtained in step (1), step (2) with step (3), step (4), step (5), step (6), step (7), and step (8) The obtained fine powders are mixed, added with refined honey and stirred evenly, and then prepared into pills of 10 g each.

The property of medicine of Chinese medicine used in the present invention is as follows:

Eucommia: sweet in taste; slightly pungent; warm in nature. Enter liver; Kidney channel. Invigorate liver and kidney; strengthen muscles and bones. Cure mainly lumbar spine pain; Rheumatic arthralgia. "Prescriptions for Emergencies and Thousands of Gold" contains: "Dispelling rheumatism, relieving numbness and pain, nourishing liver and kidney, replenishing qi and blood, feeling wind-cold and damp evil, cold pain in the waist and knees, difficulty in flexion and extension of limb joints, or numbness, chills and warmth." Modern medical research has confirmed that Eucommia has a calming effect on the nerve center, can enhance the immune function of cells, promote the secretion of cortisol and the metabolism of cAMP and cGMP in plasma.

Dipsacus: bitter in the mouth; pungent; slightly warm in nature. Return liver; Kidney channel. Invigorate liver and kidney; strengthen muscles and bones; regulate blood vessels; continue broken injuries; stop metrorrhagia. For low back pain; flaccidity of extremities; trauma from falls; damaged discs and broken bones; carbuncle sores. "Syndrome and Treatment Criteria" contains: "Sweet and warm to help yang, pungent to dispel blood stasis, both tonify liver and kidney, strengthen bones, and benefit blood vessels." Modern medical research has confirmed that Dipsacus contains a variety of alkaloids and trace elements Titanium has the effect of resisting vitamin E deficiency, and has the functions of draining pus, stopping bleeding, analgesic and promoting tissue regeneration for carbuncle.

Semen Cuscutae: spicy in the mouth; sweet; flat in nature. Enter liver; Kidney; Spleen channel. Tonify the kidney and replenish essence; nourish the liver and improve eyesight; strengthen tires and stop diarrhea. Cure mainly waist and knee pain; nocturnal emission; impotence; premature ejaculation; infertility; thirst; stranguria; enuresis; dizziness and tinnitus; restless fetal movement; miscarriage; "Materia Medica Huiyan" contains: "The medicine for nourishing the kidney and liver, warming the spleen and helping the stomach, but it is not harsh, warm but not dry, deficiency can be nourished, reality can be beneficial, cold can be warm, heat can be cool, and temperature can be dry." , Dryness can moisten.” Modern medical research has confirmed that Cuscuta can significantly protect liver damage activity, increase non-specific resistance, enhance sexual vitality, in addition to anti-tumor, anti-inflammation, anti-sterility, diarrhea and inhibition of the central nervous system role.

Atractylodes macrocephala: bitter in the mouth; sweet; warm in nature. Return spleen; Stomach warp. Invigorate the spleen and replenish qi; dry dampness and diuresis; stop perspiration; prevent miscarriage. Indications for weakness of temper, mental fatigue, lack of food, abdominal distension, loose stool, internal cessation of water and drink, dysuria, edema, dizziness due to phlegm and drink, soreness due to dampness, spontaneous sweating due to qi deficiency, restless fetal movement. "Ben Jing Feng Yuan" contains: "The operation, raw and used, has the functions of dehumidification and dryness, eliminating phlegm and diuresis, curing wind-cold-damp arthralgia, dead muscle spasm, dispersing blood between the waist and umbilical cord, and rushing the pulse for disease, and the power of inverse qi and shortness of breath; When cooked, it has the effects of harmonizing the middle and replenishing qi, quenching thirst and promoting body fluid, stopping sweat and removing heat, eating and drinking, and preventing miscarriage." Modern medical research has confirmed that Atractylodes macrocephala can strengthen and improve the body's resistance to disease, and enhance the function of the reticuloendothelial system. Phagocytosis function, enhance the function of white blood cells to phagocytose Staphylococcus aureus, have a whitening effect on leukopenia, increase the transformation rate of lymphocytes, promote cellular immune function, and be effective against Staphylococcus aureus, hemolytic streptococcus, streptococcus viridans, and pneumococcus , Meningococcus, Bacillus diphtheria, and Bacillus subtilis have different degrees of inhibitory effects, and have certain inhibitory effects on skin fungi such as Epidermophyton flocculus, Nocardia asteroides, Trichophyton violaceum, and Trichophyton concentricum.

Xianlingpi: acrid in the mouth; sweet; warm in nature. Enter liver; Kidney two warps. Tonify kidney and strengthen yang; dispel wind and dampness; strengthen tendons and bones. Indications for soreness and weakness of the waist and knees; rheumatic arthralgia; hemiplegia; inhumane limbs. "Materia Medica" contains: "The liver governs the tendons, the kidney governs the bones, and the kidney and liver strengthen the muscles and bones. Xin can relieve stagnation, sweetness can relieve the middle, and temperature can ventilate Qi and promote blood circulation. Therefore, it is the main scrofula, red carbuncle, and lower part. Sores, wash out worms.” Modern medical research has confirmed that Xianlingpi has a significant inhibitory effect on Staphylococcus albus and Staphylococcus aureus, and has a slight inhibitory effect on catarrhal bacteria, Streptococcus pneumoniae, and Haemophilus influenzae Function, can reduce hematocrit, accelerate erythrocyte sedimentation rate, reduce specific viscosity of whole blood, and increase DNA synthesis rate.

Lycium barbarum: sweet in taste; flat in nature. Return liver; Kidney; Lung meridian. Nourishes the liver; nourishes the kidney; nourishes the lungs. Indications for liver and kidney deficiency; dizziness; clear vision; soreness of the waist and knees; "Materia Medica" contains: "Improving eyes and ears, adding essence and strengthening marrow, strengthening bones and tendons, replenishing overwork injuries, especially quenching thirst." Modern medical research has confirmed that wolfberry can regulate the body's immune function, effectively inhibit tumor growth and Cell mutation has the effects of delaying aging, anti-fatty liver, regulating blood lipid and blood sugar, and promoting hematopoietic function.

Cinnamon: acrid in taste; bitter; hot in nature. Go into kidney; Spleen; Heart; Liver Channel. Replenishing fire and supporting yang; drawing fire back to its source; dispelling cold and relieving pain; warming meridians and dredging channels. Indications for deficiency of kidney yang; Mingmen fire; aversion to cold and cold limbs; soreness of the waist and knees; impotence and nocturnal emission; dysuria or frequent urination; Yang; upper heat and lower cold; bare feet and cold face; dizziness and tinnitus; broken mouth and tongue; spleen and kidney deficiency and coldness; cold pain in the abdomen; loss of appetite and loose stools; kidney deficiency and low back pain; cold-damp arthralgia; cold hernia pain; Dysmenorrhea and amenorrhea; postpartum stasis and abdominal pain; yin and gangrene outflow; "Medicine Properties" contains: "Indications for treating nine kinds of heartache, killing three insects, breaking blood, tonifying moon closure, treating soft feet, numbness, inhumanity, persistent clothes, except coughing, stagnation of qi, numbness, and stopping cold air in the abdomen. , the pain is unbearable, the main diarrhea, nasal polyps. Killing grass poison." Modern medical research has confirmed that cinnamon contains cinnamaldehyde, cinnamyl acetate, phenylpropanol acetate and other ingredients, which have aroma and stomach, antipyretic and analgesic, antibacterial and anti-inflammatory role.

Bupleurum: bitter in the mouth; pungent; slightly cold in nature. Return liver; Gallbladder channel. Relieve exterior and reduce fever; soothe the liver and relieve stagnation, elevate yang energy. Indications: fever due to exogenous pathogenesis; alternating cold and heat; malaria; stagnation of the liver, hypochondriac pain, breast distension, headache, dizziness, irregular menstruation, prolapse of the anus due to qi deficiency, uterine prolapse, gastroptosis. "Compendium" contains "treatment of sunken yang, calming the liver, gallbladder, triple burner, enveloping phase fire, headache, dizziness, dizziness, red pain, blurring, deafness and ringing, various malaria, and fat qi, cold and heat, and women's heat into the body." Blood chambers, irregular menstruation, residual heat in children with acne, and fever in five malnutrition.” Modern medical research has confirmed that Bupleurum has antipyretic, sedative, analgesic, antitussive, and anti-inflammatory effects, and at the same time resists liver damage, promotes gallbladder, Anti-fatty liver, and promote intestinal peristalsis have certain effects.

Rhizoma Cyperi: spicy in the mouth; slightly cold in nature; nontoxic. Return liver; Lung; Spleen; Stomach; Sanjiao meridian. Regulating qi and relieving depression; regulating menstruation and relieving pain; antiabortive. Indications for hypochondrium distension and pain; breast swelling; hernia pain; irregular menstruation; abdominal fullness and pain; belching and acid regurgitation; nausea; "Compendium" contains: "When the qi is cold and the disease is dispersed, the triple energizer is relieved, the stagnation of women is relieved, the food accumulation is eliminated, the phlegm is full, the hock is swollen, the abdominal distension, beriberi, all the pains of the trusted subordinates, limbs, head, eyes, teeth, and ears are relieved. Carbuncle sores, hematemesis, hematuria, hematuria, metrorrhagia in women, irregular menstruation, prenatal and postpartum diseases." Modern medical research has proved that Cyperus cyperi can regulate the function of the nervous system, has the functions of strengthening the heart, slowing down the heart rate, Lower blood pressure, prevent hyperlipidemia and atherosclerosis.

Tangerine peel: acrid in the mouth; sweet; cold in nature. Enter spleen; Stomach warp. lowering the breath; regulating the middle; resolving phlegm; sobering up. Indications for eating disorders; Shangqi fullness; Injury to wine and thirst. "Rihuazi Materia Medica" contains: "Skinburn for soup can relieve alcohol poisoning and alcohol thirst. Those who recover from typhoid fever diet should take thick decoction." Medical clinical research shows that hesperidin contained in tangerine peel can inhibit gastric ulcer , reduce capillary permeability, adjust gastrointestinal function and anti-inflammatory effect, its volatile oil has expectorant, asthma, promote digestive juice secretion and eliminate intestinal gas, in addition to dilating coronary arteries, lower blood pressure and benefit The role of gallbladder and so on.

Salvia miltiorrhiza: bitter in taste; slightly cold in nature; nontoxic. Enter the heart; Liver Channel. Promoting blood circulation and regulating menstruation; dispelling blood stasis and relieving pain; cooling blood and eliminating carbuncle; Cure mainly trusted subordinate evil spirits; accumulation of cold and heat; pathogenic wind retains heat. "The Classic" contains: "mainly trustworthy evil spirits, borborygmus like running water, accumulation of cold and heat; dispelling symptoms and eliminating abdominal pain, stopping restlessness and fullness, and replenishing qi." Modern medical research has confirmed that salvia miltiorrhiza can increase the activity of fibrinolytic enzymes, prolong bleeding, Coagulation time, inhibit platelet aggregation, dilate coronary and peripheral blood vessels, increase myocardial blood flow, promote tissue repair and regeneration, promote fibroblast differentiation and collagen fiber formation, and inhibit the synthesis of intracellular primary cholesterol

Poria cocos: sweet in taste; light; flat in nature. Go into the heart; Spleen; Lung; Kidney channel. Dampness and diuresis; invigorates the spleen and stomach; calms the mind and calms the nerves. Indications: Difficulty in urination; edema and fullness; phlegm retention and cough; vomiting; insufficiency of the spleen and lack of food; diarrhea; palpitations and restlessness; insomnia and amnesia; "Bie Lu" contains: "Quiet thirst, sleep well, big belly, dripping, phlegm in the diaphragm, edema and nodules. Open chest and viscera, adjust viscera, cut kidney evil, grow yin, benefit energy, protect the spirit and keep the center "Modern medical research has confirmed that Poria cocos has inhibitory effects on Staphylococcus aureus, Escherichia coli, Proteus, etc., can kill bacteria such as Leptospira, and has a certain protective effect on the digestive system, blood system and central nervous system. In addition, the content of pachymansin is very high, which has anti-tumor activity.

Cortex Moutan: bitter in taste; cool in nature, slightly cold, heart-guiding; liver; kidney; lung meridian. Heat-clearing; Blood circulation promoting and blood stasis dispelling. Indications: febrile disease with heat entering the blood system; spotting; vomiting of nosebleeds; hot tears filling the eyes and causing fever in the late stage of pathogenic bacteria; hot flashes due to yin deficiency and bone steaming; amenorrhea due to stagnation of blood; dysmenorrhea; carbuncle sores; ; Rheumatic fever numbness. "Compendium of Materia Medica": Cortex Moutan can control the four meridians of hand, foot, Shaoyin and Jueyin to subdue fire. Gaifuhuo is yin fire, and yin fire is phase fire. The ancient prescription is only used to treat phase fire, so Zhongjing Shenqi Pill is used. Later generations used Huang Tier to treat the phase fire, but they didn't know that the power of paeonol was even better. The red flowers are beneficial, and the white flowers are nourishing. People rarely understand it, so it is better to distinguish them.

Rhizoma Chuanxiong: pungent in taste; warm in nature. Return liver; Gallbladder; Pericardium Channel. Promoting blood circulation and dispelling blood stasis; Promoting qi to relieve stagnation; Dispelling wind and relieving pain. Indications for lumps in the abdomen; chest and hypochondriac pain; headache and dizziness; anemofrigid-damp arthralgia; bruises; carbuncle sores. "Materia Medica" contains: "dispelling wind and cold, treating pain, breaking blood stasis, dredging blood vessels, relieving knots, expelling pain, draining pus and swelling, expelling blood and stimulating menstruation." The cells have a certain effect, and the preparation has a certain antibacterial effect, especially for typhoid bacillus, paratyphoid bacillus, vibrio cholerae, Pseudomonas aeruginosa and pathogenic skin fungi. Sodium acid has the effect of promoting blood circulation and removing blood stasis, can expand coronary arteries, increase coronary flow, relieve angina pectoris, and has antithrombotic effects. Ligusticum lactone contained in it can relieve spasm of smooth muscle and inhibit intestinal muscle and uterine contraction.

Radix Paeoniae Rubra: Bitter in the mouth; slightly cold. Return liver channel. Clearing heat and cooling blood; dissipating blood stasis and relieving pain. Indications of warm toxin-spotted spots, vomiting blood and epistaxis; conjunctival congestion and swelling; liver depression and hypochondriac pain; amenorrhea dysmenorrhea; lumps in the abdomen and abdominal pain; injuries from falls; carbuncles and sores. "Shen Nong's Materia Medica" contains: "Taste bitter and flat, govern evil abdominal pain, eliminate blood numbness, break hard accumulated cold and heat, hernia, relieve pain, and produce rivers and valleys." Modern medical research has confirmed that Radix Paeoniae Rubra has changes in patients with coronary heart disease with high viscosity blood. The role of blood rheology can reduce the viscosity ratio of whole blood and the electrophoresis time of red blood cells, and can antagonize atherosclerosis by affecting calcium metabolism. It can be used to improve appetite, digestive function and certain nervous disorders.

Polygonum multiflorum: bitter in taste; sweet; astringent; slightly warm in nature. Return liver; Kidney channel. Nourishing blood and nourishing yin; moistening bowel and laxative; cutting off malaria; expelling wind; detoxification. Indications: Blood deficiency, dizziness, palpitations, insomnia, weakness of the waist and knees due to liver and kidney yin deficiency, premature graying of the beard and hair, tinnitus, nocturnal emission, dryness of the intestines and constipation, chronic malaria, body deficiency, rubella and itching, sores and carbuncles, scrofula. "Compendium of Materia Medica": Polygonum multiflorum, the white one enters the qi component, and the red one enters the blood component. Kidney governs storage, liver governs catharsis, the temperature and taste of this substance are bitter and astringent, bitter nourishes kidney, warms and nourishes liver, and can astringe essence, so it can nourish blood and nourish liver, solidify essence and kidney, strengthen muscles and bones, and black hair. It is a good nourishing medicine. Cold is not dry, the merit lies in the medicines of rehmannia glutinosa and asparagus. Qi and blood are too harmonious, and then the diseases of wind deficiency, carbuncle, and scrofula can be known (eliminated).

Curcuma: acrid in the mouth; Bitter; Warm in nature. Return liver; Spleen channel. Promoting qi and breaking blood; eliminating stagnation and relieving pain. Cure mainly blood qi and heartache; dietary stagnation; epigastric distension and pain; amenorrhea due to stagnation of blood; dysmenorrhea; "Medicine and Medicine" contains: "It is pungent and strong, and it focuses on the blood in the qi. It mainly breaks the accumulation and eliminates the hardiness, removes the accumulation of addiction, amenorrhea, blood stasis, and pain." It has obvious inhibitory and destructive effects on growth, inhibits the nuclear metabolism of tumors and cancer cells, significantly increases the content of lymphocytes in the blood, enhances the immunogenicity of tumor cells, induces or promotes the body's immune rejection of tumors, and improves the effect of radiotherapy . Oral decoction, powdered or powdered into pills; externally decocted for washing or powdered for application. It is often used for promoting qi and relieving pain, and it is suitable for stir-frying with vinegar for breaking blood and removing blood stasis.

Antler: sweet in taste; salty; warm in nature. Enter kidney; Liver Channel. Strengthening kidney yang; benefiting essence and blood; strengthening muscles and bones; supporting sores. Indications for kidney yang deficiency, impotence and spermatorrhea, uterine cold and infertility, fatigue and thinness, fatigue and chills, vertigo, tinnitus and deafness, low back pain, muscle and bone flaccidity, five delayed children, metrorrhagia in women, vaginal gangrene. "Compendium of Materia Medica" contains: "Treating deficiency and fatigue such as malaria, thinness, sore limbs, back pain, dysmenorrhea, ejaculation, drowning, bleeding in the abdomen, scattered stones, carbuncle, bone Heat, gangrene and itching." Modern medical research has confirmed that deer antler is rich in amino acids, lecithin, vitamins and trace elements, which can improve the body's cellular and humoral immunity, promote the transformation of lymphocytes, and have the effect of an immune booster. It can increase the body's defense ability against the outside world, regulate the immune balance in the body to avoid the occurrence of diseases, and promote wound healing and recovery of the sick body.

Chuan Achyranthes bidentata: sweet in taste; slightly bitter; flat in nature. Enter liver; Kidney channel. Promoting blood circulation and removing blood stasis; Expelling wind and dampness. Indications for amenorrhea due to blood stasis; dystocia; persistent afterbirth; postpartum stasis and abdominal pain; hot stranguria; stone stranguria; dysmenorrhea; rheumatism waist and knee pain. "Sichuan Traditional Chinese Medicine" contains: "Expelling wind and dampness, clearing the meridian and dispersing blood, treating gonorrhea, hematuria, and drowning." Modern medical research has confirmed that the insect metamorphic steroid contained in Achyranthes bidentata has a strong protein synthesis promoting effect .

Alisma: sweet in the mouth; light; cold in nature. Return kidney; Bladder channel. Diuresis and dampness expelling; Expelling heat and treating stranguria. Indications: Difficulty in urination; hot stranguria with astringent pain; edema and fullness; diarrhea; dizziness due to phlegm retention; spermatorrhea. "Bie Lu" contains: "Replenishing deficiency and impairing the five fatigues, eliminating fullness of the five internal organs, promoting yin qi, stopping leakage of essence, quenching thirst, leaching, expulsion of the bladder, and water loss of the triple burner." Modern medical research has confirmed that Alisma has the effect of lowering cholesterol. And prevent atherosclerosis, improve liver fat metabolism, lower blood sugar, blood pressure, affect immune system function, and reduce serum hemolysin.

Pinellia: acrid in taste; warm in nature; slightly cold. Enter spleen; Stomach warp. Drying dampness and resolving phlegm; lowering adverse flow and stopping pain; dispelling lump and dissipating stagnation; externally eliminating carbuncle. "Bie Lu" contains: "eliminate carbuncle, treat chlorosis, and brighten the face." Modern medical research has confirmed that pinellia has a significant antitussive effect, can inhibit the secretion of glands, inhibit the hydrolysis of trypsin, and reduce blood pressure, coagulation, and promote cell division.

Teng Ye Jiao Teng: sweet in taste; slightly bitter; flat in nature. Enter the heart; Liver Channel. Nourish the mind and calm the nerves; dispel wind; dredge collaterals. Indications for insomnia; dreaminess; blood deficiency body pain; skin numbness; rheumatic arthralgia; rubella itching. "New Ginseng of Decoction Pieces" contains: "Nourish the liver and kidney, stop sweating due to deficiency, soothe the nerves and hypnotize the mind, invigorate the Qi, line the meridians, unblock the blood vessels, and treat overworked injuries." Modern medical research has confirmed that Yejiaoteng contains emodin, emodin methyl ether, and Sodium pentobarbital acts synergistically and has significant sedative and hypnotic effects, especially prolonging the phase of slow-wave sleep.

Chuan Fritillaria: sweet in taste; bitter; slightly cold in nature. Return lung; Heart Sutra. Clearing away heat and nourishing the lungs; resolving phlegm and relieving cough; dispelling stagnation and reducing swelling. Indications for lung deficiency; chronic cough; cough due to asthenia; cough due to dryness and heat; lung abscess; scrofula; carbuncle; mastitis. "Materia Medica Huiyan": Fritillaria, the medicine for dispelling depression, lowering qi, and resolving phlegm. Moisturizing the lungs and eliminating phlegm, relieving cough and relieving asthma, for symptoms of asthenia and fire knots, Fritillaria is the first dose. Therefore, when combined with Anemarrhena, it can clear qi and nourish yin; with Qin and Lian, it can clear phlegm and reduce fire; Gall stone under the item; it can be used with Erchen Dai Pinellia, which can nourish the lungs and eliminate phlegm, and reduce fire in the middle. For the above repairs, the Sichuan one must be the best. If it is used to detoxify carbuncle, break the crux of the problem, eliminate excess phlegm, and apply it to malignant sores, it is better to use soil. However, the Sichuan one has a good taste, while the soil one has a poor taste and bitterness, and the two are used separately. Modern medical research has confirmed that Chuan Fritillaria has significant antitussive and expectorant effects, significantly inhibits pepsin and stress ulcers, and inhibits the central nervous system.

Licorice: sweet in taste; neutral in nature. Guixin; Lung; Spleen; Stomach Channel. Invigorating the spleen and replenishing qi; clearing heat and detoxifying; eliminating phlegm and relieving cough; relieving spasm and relieving pain; reconciling various medicines. Indications for weakness of the spleen and stomach; fatigue and fatigue; palpitations and shortness of breath; cough with excessive phlegm; acute pain in the abdomen and legs; carbuncle sores; relieve drug toxicity. "Compendium of Materia Medica" contains: "Glycyrrhiza is the king of all medicines. It cures seventy-two kinds of milk stone poisons, solves 1,200 kinds of herbal poisons, and reconciles medicines." Modern medical research has confirmed that licorice has a strong detoxification effect , as well as anti-ulcer, anti-inflammation, antispasmodic and antitussive, lowering blood pressure, lowering blood fat, anti-cancer effects, widely used in the treatment of pharyngitis, laryngitis, tracheitis, bronchitis, asthma, cough, hemoptysis and other diseases, in addition It also has anti-gastric ulcer and anti-gastritis effects.

Cornus officinalis: sour in taste; slightly warm in nature, returns to liver; kidney meridian. Replenishing the liver and kidneys; astringing and solidifying. Cure mainly: waist dizziness, deafness and tinnitus, soreness and weakness of the waist and knees, sperm essence and essence, frequent urination, profuse sweating, metrorrhagia in women. "Introduction to Medicine": Cornus officinalis is also an astringent, how can it relieve evil? All diseases are caused by deficiency and cold in the lower part. Use it to nourish the liver and kidney to benefit its source, and the five internal organs will be relieved. Modern medical research shows that Cornus officinalis has the functions of antibacterial, immune regulation, hypoglycemic, hypolipidemic, antioxidative, anticancer, antiAIDS, and cardiac strengthening.

Curculigo: acrid in the mouth; warm in nature; poisonous. Enter kidney; Liver Channel. Warming kidney and strengthening yang; dispelling cold and dampness. Indications for impotence and essence cold; urinary incontinence; epigastric cold and pain; waist and knee pain; weakness of muscles and bones; spasms of lower limbs; menopausal syndrome. "Herbal Medicinal Preparations" contains: "Tonify the kidney, relieve pain, treat white turbidity, regulate phlegm fire, cook meat. Ten steams and nine suns can strengthen the spirit and black hair." Clinical medical research shows that curculigo can significantly improve the macrophage Phagocytosis of cells, enhancing immune function, significantly prolonging sleep time, significantly prolonging the incubation period of toxin-induced convulsions, increasing the activity of Na-ATPase, in addition to antibacterial, anti-tumor, dilating coronary arteries, strengthening the heart, lowering blood pressure and anti-inflammatory effects. Inflammatory effect.

Compared with the prior art, the present invention has the following beneficial effects:

The present invention selects medicinal materials Jun, Chen, Zuo, so that all the principles are prepared, and the properties of the medicines are compatible and complementary, aiming at the causes of gynecomastia, such as liver and kidney dystrophy, poor Qi and blood, stagnation of liver and phlegm, stagnation of Qi and blood stasis, etc. Prescribing the right medicine has the effects of nourishing the liver and kidney, soothing the liver and relieving stagnation, promoting blood circulation and dredging collaterals, resolving phlegm and dispelling stagnation, good absorption effect, significant curative effect, no toxic side effects and clinical adverse reactions, and has been clinically proven to have a high cure rate for gynecomastia .

Detailed ways

The present invention will be further elaborated below in conjunction with specific embodiments.

Example 1

The raw material composition and the weight of active ingredient of medicine of the present invention are:

The processing steps of the pharmaceutical preparation method of the present invention are:

(1) Wash wolfberry, cornus, cinnamon, poria cocos, Moutan bark, Bupleurum chinensis, tangerine peel, Achyranthes bidentata, Pinellia chinensis, night cross vine, licorice, mix well after drying, and put them in a container. Add 6 to 8 times the amount of water in the container, heat and boil for 3 to 4 hours, take the infusion after cooling; add 4 to 6 times the amount of water to the remaining medicinal residues, heat and boil for 2 to 3 hours, after cooling Infusion solution; combine the two obtained infusion solutions, heat, evaporate and concentrate to a thick paste with a relative density of 1.10-1.20, and set aside;

(2) Put Polygonum multiflorum, Dipsacus, and Cuscuta into a container, add 3 to 5 times the amount of Shaoxing rice wine, boil and let cool, continue to soak for 3 to 4 hours, and take the infusion; add 2 ～3 times the amount of Shaoxing rice wine, boiled and let it dry, continue to soak for 2 to 3 hours, take the infusion; combine the two infusions, evaporate and concentrate to a thick paste with a relative density of 1.15 to 1.25, and set aside;

(3) Crush velvet antler, zedoary and fritillary fritillaria, grind them into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside;

(4) Put Atractylodes macrocephala, Rhizoma Chuanxiong, Radix Paeoniae Rubra, and curculigo in an iron pan, stir-fry over low heat until the skin turns yellow, sprinkle Jimo old wine, continue to stir-fry until the skin is brown, take it out and let it cool, grind it into powder, and over 120-mesh fine sieve to get fine powder, set aside;

(5) Wash and slice Cyperus cyperi, add a certain amount of rice vinegar, mix well, moisten until the vinegar is completely absorbed, put it in a frying container, heat it with a slow fire and fry it dry, take it out and let it cool. Sieve to remove debris, pulverize into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside;

(6) Take a certain amount of table salt and dissolve it in clear water, mix it evenly into the Eucommia medicinal material, heat it in a pot and stir-fry until dry, the surface color of the medicinal material is slightly darker, sieve off the debris, grind it into powder, pass through a 120-mesh fine sieve, Get fine powder, set aside;

(7) Heat and melt suet in a pot, then add fairy spleen, mix well and stir-fry until the suet is exhausted, the medicinal materials are crispy, sieve off debris, grind into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside ;

(8) Take Salvia miltiorrhiza and Alisma, wash and slice, dry in the sun, add Salvia miltiorrhiza and Alisma, stir-fry several times, spray with rice wine, fry dry, pulverize, pass through a 120-mesh fine sieve to obtain fine powder, and set aside;

(9) Combine the thick paste obtained in step (1), step (2) with step (3), step (4), step (5), step (6), step (7), and step (8) The obtained fine powders are mixed, added with refined honey and stirred evenly, and then prepared into pills of 10 g each.

Dosage: oral administration, 2 pills each time 3 times a day, 3 pills each time 3 times a day for severe patients, before meal

Take it with warm boiled water or warm rice wine within one hour, and take 24 days as a course of treatment.

Example 2

The process steps, usage and dosage of the medicine preparation method in this embodiment are the same as those in Example 1.

Example 3

The raw material composition and the weight of active ingredient of medicine of the present invention are:

The process steps, usage and dosage of the medicine preparation method in this embodiment are the same as those in Example 1.

clinical information:

1. Case selection

60 patients with gynecomastia diagnosed in our hospital or other hospitals were selected for clinical observation, and the patients were randomly divided into two groups. Treatment group 30 cases, male, aged 45 to 65 years, with an average age of 56.6 years. The control group consisted of 30 males, aged 47 to 64 years, with an average age of 55.4 years. The qualifications of the two groups are basically the same, there is no significant difference, and they are comparable.

2. Patients in the treatment group took the medicine of the present invention orally, 2 pills each time 3 times a day, 3 pills each time 3 times a day for severe patients, and took it with warm boiled water or warm rice wine one hour before meals, 24 days as a course of treatment , taking three courses of treatment. The control group was treated with dihydrotestosterone heptanoate, tamoxifen, clomiphene, and testosterone lactone, respectively, according to the type of gynecomastia diagnosed.

3. Judgment of curative effect:

(1) Cure: the clinical symptoms disappeared obviously, the mass on palpation disappeared, and the pain disappeared.

(2) Improvement: the clinical symptoms were significantly relieved, the palpation mass shrunk, and the pain was obviously relieved.

(3) Ineffective: There was no significant change in clinical symptoms before and after treatment.

4. Results

In the treatment group, 21 cases were cured, 7 cases improved, and 2 cases were ineffective. The cure rate was 70%, and the total effective rate was 93.33%.

In the control group, 18 cases were cured, 8 cases improved, and 4 cases were ineffective. The cure rate was 60%, and the total effective rate was 86.67%.

The above results showed that the cure rate and total effective rate of the treatment group were significantly higher than those of the control group.

Typical case example:

1. Zhao XX, male, 47 years old, the patient found double breast swelling and distending pain half a year ago. Touch the 11×11cm disc-like mass, matter is hard, the activity of pushing, smooth surface, clear boundary, tenderness and tenderness are obvious. It is diagnosed as gynecomastia (both sides), after taking the pills of the present invention for 1 course of treatment, further consultation, Both breasts collapsed obviously, and the lump softened and shrunk. After taking two courses of treatment, the lump all dissipated, and there was no pain in palpation. Both breasts returned to normal and were cured.

2. Yang Moumou, male, 61 years old, had a lump in his right breast with distending pain for nearly two years. He came to our hospital for physical examination and treatment. The symptoms showed that the right breast was obviously swollen, and a large mass of 8x7cm was touched under the nipple with a clear boundary. The activity of pushing, the surface is smooth, tenderness and tenderness are arranged, and no abnormality is seen in the left breast. It is diagnosed as gynecomastia (right side), and after taking the pill of the present invention for 1 course of treatment, the lump is obviously softened and dwindles to 5x5cm, The pain on palpation was obviously relieved, and after taking two courses of treatment, the lump dissipated, and there was no pain in palpation, and the shape of the right breast was not significantly different from that of the left side.

According to the analysis of clinical treatment statistical data, this disease mainly occurs in middle-aged and elderly people. The main cause is the loss of liver and kidney. Tonifying the kidney, promoting blood circulation and removing blood stasis, taking into account both the symptoms. In the prescription, traditional Chinese medicines such as eucommia ulmoides, fleece-flower root, celestial spirit spleen, curculigo, medlar, cornus and other traditional Chinese medicines warm and nourish the liver and kidney, and regulate Chong Ren; Traditional Chinese medicines such as invigorating the spleen and harmonizing the stomach, promoting qi and resolving phlegm, Danshen, Chuan Achyranthes bidentata, Curcuma, Chuanxiong and other traditional Chinese medicines promote blood circulation and remove blood stasis, resolve phlegm and dissipate stagnation, and then use licorice to reconcile the various medicines to protect the liver and kidney, promote blood circulation and remove blood stasis, reasonable Regulate endocrine, make the hormone level in the body keep relative balance, from the treatment effect of this group 30 cases, use pill described in the present invention to treat gynecomastia, curative effect is very remarkable, and has no side effect.

Claims (4)

1. a pill for the treatment of gynecomastia, characterized in that: the composition of raw materials and the parts by weight for making the active ingredient of the drug are: . 2. a kind of pill for the treatment of gynecomastia according to claim 1, is characterized in that: The composition and parts by weight of raw materials for making the active ingredients of the drug are: . 3. a kind of pill for the treatment of gynecomastia according to claim 1 and the preparation method, is characterized in that: the raw material composition and the parts by weight of making described medicine active ingredient are: . 4. a preparation method for a pill for the treatment of gynecomastia, characterized in that: comprising the following process steps: (1) Wash wolfberry, cornus, cinnamon, poria cocos, Moutan bark, Bupleurum chinensis, tangerine peel, Achyranthes bidentata, Pinellia chinensis, night cross vine, licorice, mix well after drying, and put them in a container. Add 6 to 8 times the amount of water in the container, heat and boil for 3 to 4 hours, take the infusion after cooling; add 4 to 6 times the amount of water to the remaining medicinal residues, heat and boil for 2 to 3 hours, after cooling Infusion solution; combine the two obtained infusion solutions, heat, evaporate and concentrate to a thick paste with a relative density of 1.10-1.20, and set aside; (2) Put Polygonum multiflorum, Dipsacus, and Cuscuta into a container, add 3 to 5 times the amount of Shaoxing rice wine, boil and let cool, continue to soak for 3 to 4 hours, and take the infusion; add 2 ～3 times the amount of Shaoxing rice wine, boiled and let it dry, continue to soak for 2 to 3 hours, take the infusion; combine the two infusions, evaporate and concentrate to a thick paste with a relative density of 1.15 to 1.25, and set aside; (3) Crush velvet antler, zedoary and fritillary fritillaria, grind them into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside; (4) Put Atractylodes macrocephala, Rhizoma Chuanxiong, Radix Paeoniae Rubra, and curculigo in an iron pan, stir-fry over low heat until the skin turns yellow, sprinkle Jimo old wine, continue to stir-fry until the skin is brown, take it out and let it cool, grind it into powder, and over 120-mesh fine sieve to get fine powder, set aside; (5) Wash and slice Cyperus cyperi, add a certain amount of rice vinegar, mix well, moisten until the vinegar is completely absorbed, put it in a frying container, heat it with a slow fire and fry it dry, take it out and let it cool. Sieve to remove debris, pulverize into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside; (6) Take a certain amount of table salt and dissolve it in clear water, mix it evenly into the Eucommia medicinal material, heat it in a pot and stir-fry until dry, the surface color of the medicinal material is slightly darker, sieve off the debris, grind it into powder, pass through a 120-mesh fine sieve, Get fine powder, set aside; (7) Heat and melt suet in a pot, then add fairy spleen, mix well and stir-fry until the suet is exhausted, the medicinal materials are crispy, sieve off debris, grind into powder, pass through a 120-mesh fine sieve to obtain fine powder, and set aside ; (8) Take Salvia miltiorrhiza and Alisma, wash and slice, dry in the sun, add Salvia miltiorrhiza and Alisma, stir-fry several times, spray with rice wine, fry dry, pulverize, pass through a 120-mesh fine sieve to obtain fine powder, and set aside; (9) Combine the thick paste obtained in step (1), step (2) with step (3), step (4), step (5), step (6), step (7), and step (8) The obtained fine powders are mixed, added with refined honey and stirred evenly, and then prepared into pills of 10 g each.