CN104524304A

CN104524304A - Traditional Chinese medicine composition for treating bronchial inflammation

Info

Publication number: CN104524304A
Application number: CN201510011768.3A
Authority: CN
Inventors: 王乃伟
Original assignee: Individual
Current assignee: Individual
Priority date: 2015-01-09
Filing date: 2015-01-09
Publication date: 2015-04-22

Abstract

The invention discloses a traditional Chinese medicine composition for treating bronchial inflammation. The traditional Chinese medicine composition consists of, by weight, 3-5 parts of platycodon grandiflorum, 6-8 parts of chrysanthemum, 5-10 parts of honeysuckle, 3-5 parts of radix scutellariae, 2-4 parts of selfheal, 2-5 parts of mint, 5-8 parts of fritillaria, 3-4 parts of momordica grosvenori, 3-5 parts of purple perilla fruits, 2-3 parts of lalang grass rhizome, 2-3 parts of ajowan, 1-3 parts of radix rehmanniae roots, 2-4 parts of almond, 2-4 parts of lily, 2-5 parts of snake gourd fruits, 1-5 parts of houttuynia cordata, 10-20 parts of folium eriobotryae, 1-2 parts of cherokee rose fruits, 1-3 parts of dried radix rehmanniae, 5-10 parts of liquorice, 3-5 parts of periostracum cicada, 3-5 parts of hairyvein agrimony, 6-8 parts of seaweed, 2-5 parts of uncaria and 4-8 parts of caulis spatholobi. The raw materials of the traditional Chinese medicine composition are pure traditional Chinese medicine raw materials, so that the traditional Chinese medicine composition is free of toxic and side effects. The traditional Chinese medicine composition has the effects of relieving cough, reducing phlegm and diminishing inflammation, can effectively eliminate cough, excessive phlegm and other symptoms brought by bronchitis and thoroughly eradicates the bronchitis.

Description

A kind of Chinese medicine composition for the treatment of bronchitis

Technical field

The invention belongs to technical field of Chinese medicines, particularly relate to a kind of Chinese medicine composition for the treatment of bronchitis.

Background technology

Along with the development of society and the raising of economic level, the day by day serious mistake of environmental pollution.Upper respiratory tract infection and bronchitis crowd and coincidence increase mostly.Bronchitis refers to the chronic nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Bronchitis main cause is that the repeated infection of virus and antibacterial defines bronchial chronic nonspecific inflammation.When under mercury dropped, respiratory tract small blood vessel spasm ischemia, defense function, degradation is beneficial to pathogenic; The chronic stimulations such as smog dust, atmosphere pollution also can be fallen ill; Smoking makes the variation of bronchospasm, mucosa, ciliary movement reduces, mucilage secretion increases advantageous infectivity.

Bronchitis refers to the nonspecific inflammation of trachea-bronchial epithelial cell mucosa and surrounding tissue thereof.Majority is caused by antibacterial or viral infection, according to EPDML investigation, is mainly rhinovirus, syncytial virus, influenza virus and rubella virus etc.More common antibacterial is streptococcus pneumoniae, Hemolytic streptococcus, staphylococcus, hemophilus influenza, Salmonella and diphtheria corynebacterium etc.In addition temperature sudden change, dust, smog and irritative gas also can cause bronchitis.Clinically with cough, expectoration or with pant and recurrent exerbation for feature.Divide again chronic bronchitis and acute bronchitis two kinds.Acute bronchitis with rhinorrhea, heating, cough, expectoration for cardinal symptom, and friction pain after having pharynx hoarseness, laryngalgia, slight breastbone.Initial stage expectorant is few, in viscosity, becomes purulence later.Flue dust and cold air etc. stimulate can make cough increase the weight of.Chronic bronchitis main manifestations is chronic cough, and particularly cough increases the weight of sooner or later.If secondary infection, generate heat, be afraid of cold, vomica.Winter is the season occurred frequently of this disease.

" bronchitis research report in 2011 " points out chronic bronchitis clinically with long-term intractable bronchitis: cough as feature.When morning and evening temperature is lower or diet stimulates, again and again sends out and cough.During without complication, body temperature, pulse are unchanged.Sick just breathing is unchanged, and later because bronchial mucosa connective tissue proliferation is thickening, the change of bronchus tube chamber is narrow, then dyspnea occurs.When Complicated with Pulmonary edema due to disorder of QI, breathing is the devil, and this dyspneic feature is respiratory or blended, and has intercostal pouch and occur ceasing labor ditch.Chest auscultation, vesicluar sound strengthens, and during Complicated with Pulmonary edema due to disorder of QI, vesicluar sound weakens, and often can hear dry rale.Chest percussion pitch is bright, and lung circle is loose.X-ray checks, the bronchus shade of pulmonary increases weight and extends.Clinical research finds: negative oxygen ion effectively can strengthen the ciliary movement of tunica mucosa tracheae epithelium, affect the activity of epithelium fine hair internal respiration enzyme, improve the secretory function of alveolar and the ventilation of lung and ventilatory, thus have alleviate bronchospasm, increase vital capacity, effect such as adjustment respiratory frequency, antitussive etc.

Chronic bronchitis can be divided into simple type and type amphitypy of panting clinically.Simple type main manifestations is cough, expectoration; Type of panting then still has outward pant apart from cough, expectoration, with wheezing sound, stridulates and to aggravate when apasm of coughing, obvious during sleep.

Many slowly onsets, the course of disease is longer, repeatedly acute attack and increasing the weight of.Cardinal symptom has chronic cough, expectoration, pants.Start symptom slight, after smoking, contact harmful gas, overworked, climate change or the flu that turns cold, then cause acute attack or increase the weight of.Or by upper respiratory tract infection protracted course of disease, evolving development is chronic bronchitis.Many when to summer, weather turns warm can natural remission.

1. cough: bronchial mucosa hyperemia, edema or secretions accumulate in bronchial lumen and all can cause cough.The order of severity of cough is depending on the state of an illness, and general daystart cough is heavier, and daytime is comparatively light, has apasm of coughing or expectoration before sleeping night.

2. expectoration: owing to accumulating sputum in tube chamber after nighttime sleep, in addition parasympathetic nervous is relatively excited, and bronchial secretion increases, therefore, after getting up or position variation cause zest expectoration, often more with expectoration in early morning, sputum is generally white slimy or serosity spumescence, occasionally can be with blood.Seriously and repeatedly spit blood if having, prompting has serious pulmonary disease, as tumor.When acute attack is with actute infection, then become coctum, cough and amount of expectoration also increase thereupon.

3. to pant or out of breath: asthmatic chronic bronchitis has bronchospasm, can cause and pant, often with heavy breathing mouth rale.Early stage without phenomenon out of breath.The recurrent exerbation several years, during concurrent obstructive emphysema, can with light and heavy degree do not wait out of breath, first have work or movable after asthma, dynamicly time serious then breathe heavily very, life is rough to take care of oneself.

In a word, cough, expectorant, breathe heavily cardinal symptom for chronic bronchitis, and by its type, stadium and with or without complication, clinical there is different manifestations.Can divide for three phases by disease progression.

(1) acute attack stage: refer to occur purulence or mucous sputum in a week, amount of expectoration obviously increases, or with the performance of the inflammation such as heating, or the symptom such as " coughing ", " expectorant ", " breathing heavily " any one obviously aggravate.

(2) chronic persistence: refer to there be " coughing ", " expectorant " in various degree, " breathing heavily " symptom delays more than one month person.

(3) clinical relieving period: through treatment or clinical remission, symptom substantially disappears or occasionally has a small amount of sputum of slight cough, keeps more than 2 months persons.

In early days can without any abnormal sign.Acute attack stage can have dry, the wet ring sound be dispersed in, and how in pulmonary and base of lung portion, can reduce or disappear after cough.The number of wheezing sound or position are not necessarily.The type person that pants can hear wheezing sound and prolonged expiration, and not easily disappears completely.Emphysema sign is had during Complicated with Pulmonary edema due to disorder of QI.

" bronchitis research report in 2011 " points out that acute bronchitis cardinal symptom is cough

Respiratory system, at the beginning of disease, for short, dryness pain are coughed.After 3 ~ 4 days, along with the increase of exudate, then become wet, long coughing, pain alleviates.Often occur together after cough vomiting.Nostril, both sides stream serosity, slurry viscosity or coctum nose liquid, when coughing, discharge increases.Chest auscultation, sick just vesicluar sound strengthens, and due to the exudate of bronchial mucosa swelling and secretion thickness after 2 ~ 3 days, can hear dry rale, when the exudate that volume in bronchus is thin, hear moist rale, and with large, medium bubbling rales is more.Chest percussion, generally unchanged.General Symptoms is slight, and body temperature is normal or raise 0.5 ~ 1 DEG C, and breathing increases thick.Disease is sent out in the bronchitis Chang Fagaore of infectious disease, and has heavy acute General Symptoms.Bronchiolitis General Symptoms is heavy acute, and body temperature raises 1 ~ 2 DEG C, breathes speedup, in expiratory dyspnea, and normal mouth breathing, visual mucosa cyanosis.All there is faint short pain from the beginning to the end to cough.Usual without nose liquid, or rarely seen a small amount of nose liquid.Chest auscultation has fine bubbling rale or dry rale.In bronchioles total blockage, exudate invades to alveolar, will cause bronchitis.Chest percussion, the sore throat relieving in Gao Lang, moves after lung circle is many, and this is due to bronchial stenosis, dyspnea, and acute emophysematous result occurs.As concurrent bronchopneumonia, then there is island shape voiced sound.

Putrid bronchitis

Except General Symptoms heavily play, breath has foul smell, and flows contaminated and with putrefactive odor nose liquid.

The traditional Chinese medical science is thought, the chronic disease of this class of bronchitis, and it is marked on lung, and base will at kidney.In other words, seem that cough is pulmonary disease, but essence is suffered from a deficiency of the kidney, lung master exhale, the main suction of kidney, lung governing diffusion, kidney governing inspiration.When the state of an illness is hurried, with lung qi dispersing heat clearing away, relieving asthma, eliminating phlegm for controlling, during disease amelioration with the kidney invigorating, improving inspiration by invigorating kidney-QI, benefit essence, foster the spirit of nobility as controlling.The bronchitic medicine of current treatment is a lot, but offer limited effectiveness, and these medicines need long-term taking, once stop using, the state of an illness will recur.But long-term taking can bring a lot of side effect.

Summary of the invention

The object of the present invention is to provide a kind of Chinese medicine composition for the treatment of bronchitis.

In order to solve the problems of the technologies described above, the technical solution used in the present invention is as follows: a kind of Chinese medicine composition for the treatment of bronchitis is made up of each raw material components of following parts by weight proportioning:

Radix Platycodonis 1-5 part; Flos Chrysanthemi 5-10 part; Flos Lonicerae 1-10 part; Radix Scutellariae 1-5 part; Spica Prunellae 2-4 part; Herba Menthae 1-5 part; Bulbus Fritillariae Cirrhosae 2-8 part; Fructus Momordicae 2-4 part; Fructus Perillae 3-5 part; Rhizoma Imperatae 1-5 part; Cuminum celery 1-3 part; Radix Rehmanniae Preparata 1-3 part; Semen Armeniacae Amarum 2-6 part; Bulbus Lilii 2-5 part; Fructus Trichosanthis 2-6 part; Herba Houttuyniae 1-8 part; Folium Eriobotryae 5-20 part; Fructus Rosae Laevigatae 1-4 part; Radix Rehmanniae 1-3 part; Radix Glycyrrhizae 2-10 part; Periostracum Cicadae 2-6 part; Herba Agrimoniae 3-5 part; Sargassum 4-8 part; Ramulus Uncariae Cum Uncis 1-6 part; Caulis Spatholobi 1-10 part.

Furthermore, preferred each component parts by weight proportioning is:

Radix Platycodonis 2-5 part; Flos Chrysanthemi 5-8 part; Flos Lonicerae 2-10 part; Radix Scutellariae 3-5 part; Spica Prunellae 2-4 part; Herba Menthae 2-5 part; Bulbus Fritillariae Cirrhosae 3-8 part; Fructus Momordicae 3-4 part; Fructus Perillae 3-5 part; Rhizoma Imperatae 2-5 part; Cuminum celery 1-3 part; Radix Rehmanniae Preparata 1-3 part; Semen Armeniacae Amarum 2-6 part; Bulbus Lilii 2-5 part; Fructus Trichosanthis 2-6 part; Herba Houttuyniae 1-8 part; Folium Eriobotryae 5-20 part; Fructus Rosae Laevigatae 1-2 part; Radix Rehmanniae 1-3 part; Radix Glycyrrhizae 4-10 part; Periostracum Cicadae 2-5 part; Herba Agrimoniae 3-5 part; Sargassum 5-8 part; Ramulus Uncariae Cum Uncis 1-5 part; Caulis Spatholobi 1-8 part.

Furthermore, more preferred each component parts by weight proportioning is:

Radix Platycodonis 3-5 part; Flos Chrysanthemi 6-8 part; Flos Lonicerae 5-10 part; Radix Scutellariae 3-5 part; Spica Prunellae 2-4 part; Herba Menthae 2-5 part; Bulbus Fritillariae Cirrhosae 5-8 part; Fructus Momordicae 3-4 part; Fructus Perillae 3-5 part; Rhizoma Imperatae 2-3 part; Cuminum celery 2-3 part; Radix Rehmanniae Preparata 1-3 part; Semen Armeniacae Amarum 2-4 part; Bulbus Lilii 2-4 part; Fructus Trichosanthis 2-5 part; Herba Houttuyniae 1-5 part; Folium Eriobotryae 10-20 part; Fructus Rosae Laevigatae 1-2 part; Radix Rehmanniae 1-3 part; Radix Glycyrrhizae 5-10 part; Periostracum Cicadae 3-5 part; Herba Agrimoniae 3-5 part; Sargassum 6-8 part; Ramulus Uncariae Cum Uncis 2-5 part; Caulis Spatholobi 4-8 part.

Further, can add Semen Raphani further in described Chinese medicine composition, the addition in described Chinese medicine composition is 1-20 part.

Further, described Semen Raphani addition is 5-15 part.

Further, described Chinese medicine composition is prepared into powder, oral liquid.

In addition, the preparation method of the Chinese medicine composition of above-mentioned treatment bronchitis, it comprises: the first step, described Chinese medicine composition is mixed in proportion, be placed in super micron mill and pulverize 10 minutes ~ 60 minutes, Chinese medicine composition after pulverizing is dissolved in dehydrated alcohol and soaks 2 ~ 5 hours, add distilled water, ensure that concentration of alcohol is 60% ~ 90%, heating and refluxing extraction 2 ~ 5 times, filter, merging filtrate, vacuum decompression, obtain dry mastic, dry mastic described in vacuum drying, micronizing 10 minutes ~ 30 minutes, powder after pulverizing is added the water dissolution relative to its quality 1 ~ 6 times amount, under agitation add relative to powder quality 5% ~ 20% sodium hydroxide hydrotropy, adjust ph is neutral, filter, adding concentration is that the salt acid for adjusting pH value of 15% is for acid, quiescent setting 1 ~ 12 hour, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 100 order ~ 180 object fine powders,

Second step, according to required dosage form, adds conventional auxiliary element, the pharmaceutical composition required for preparation.

When the dosage form of described pharmaceutical composition is oral liquid, described second step is specially, the distilled water relative to its quality 1 ~ 3 times amount is added, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.05 times in the powder that the first step obtains, stir, boil, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

When the dosage form of described pharmaceutical composition is powder, described second step is specially, and adds the starch mix homogeneously relative to its quality 1 ~ 5 times, be prepared into powder in the powder that the first step obtains.

By technique scheme, the advantage that the present invention has and beneficial effect are: each raw material components of the present invention is pure raw material of Chinese medicine, thus has no side effect; The present invention has cough-relieving, reduces phlegm, the effectiveness of antiinflammatory, and effectively can eliminate the cough that bronchitis brings, many symptoms such as abundant expectoration, thoroughly eradicate bronchitis.

Detailed description of the invention

A kind of Chinese medicine composition for the treatment of bronchitis of the present invention, its raw material components comprised is: Radix Platycodonis, Flos Chrysanthemi, Flos Lonicerae, Radix Scutellariae, Spica Prunellae, Herba Menthae, Bulbus Fritillariae Cirrhosae, Fructus Momordicae, Fructus Perillae, Rhizoma Imperatae, Cuminum celery, Radix Rehmanniae Preparata, Semen Armeniacae Amarum, Bulbus Lilii, Fructus Trichosanthis, Herba Houttuyniae, Folium Eriobotryae, Fructus Rosae Laevigatae, the Radix Rehmanniae, Radix Glycyrrhizae, Periostracum Cicadae, Herba Agrimoniae, Sargassum, Ramulus Uncariae Cum Uncis, Caulis Spatholobi and Semen Raphani mix by certain parts by weight proportioning.Wherein, the main component of each Chinese medicinal components and effect are described below respectively:

1, Radix Platycodonis: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus.For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection difficulty in discharging of pus.

Nature and flavor: bitter in the mouth, pungent, property is put down.

Gui Jing: lung meridian; Stomach warp.

Effect: lung qi dispersing eliminates the phlegm, sore-throat relieving, evacuation of pus.

2, Flos Chrysanthemi: body is light, and matter is soft and moist, crisp time dry.Gas delicate fragrance, sweet in the mouth, micro-hardship.

Nature and flavor: sweet, bitter, are slightly cold.

Gui Jing: return lung, Liver Channel.

Effect: loose wind heat clearing away, suppressing the hyperactive liver improving eyesight.For anemopyretic cold, have a headache dizzy, conjunctival congestion and swelling pain, eyes is dim-sighted.

3, Flos Lonicerae

Nature and flavor: sweet, cold.

Gui Jing: return lung, the heart, stomach warp.

Function cures mainly: heat-clearing and toxic substances removing, wind-heat dissipating.For carbuncle furuncle, sore throat, erysipelas, toxic-heat and blood stasis, anemopyretic cold, epidemic febrile disease is generated heat.

4, Radix Scutellariae: heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive, blood pressure lowering.For hygropyrexia, fever disease in summer vomiting and nausea uncomfortable in chest, damp and hot feeling of fullness, dysentery, jaundice, cough due to lung-heat, high hot excessive thirst, heat in blood tells nosebleed, carbuncle sore tumefacting virus, frequent fetal movement.

Nature and flavor: bitter cold.

Gui Jing: enter lung, spleen, gallbladder, intestine and small intestine footpath.

Function: heat clearing and damp drying, arresting bleeding and miscarriage prevention.

5, Spica Prunellae:

The property of medicine: pungent, bitter, cold.Return liver, gallbladder meridian.

Effect: clearing away heat-fire, improving eyesight, mass dissipating and swelling eliminating.

Function cures mainly: effect: improving eyesight of 1. relieving inflammation or internal heat: control conjunctival congestion and swelling pain, headache; 2. clearing away liver-fire, blood pressure lowering: control hypertension, hyperlipidemia, high blood viscosity and hyperglycemia; 3. mass dissipating and swelling eliminating: control scrofula, goiter, acute mastitis swell and ache.

6, Herba Menthae labiate; Leaf, to life, spends little lavender, lip, spends the dark violet brown granule fruit of rear knot.

Meridian distribution of property and flavor: pungent is cool; Enter lung, Liver Channel;

Effect: dispelling wind and heat pathogens, the clear sharp head.

7, Bulbus Fritillariae Cirrhosae.

Nature and flavor: bitter, sweet, are slightly cold.

Gui Jing: return lung, heart channel.

Function cures mainly: clearing heat and moistening lung, preventing phlegm from forming and stopping coughing.For lung-heat type cough, the few expectorant of dry cough, deficiency of YIN chronic cough, sputum with blood.

8, Fructus Momordicae:

Nature and flavor: sweet are cool.

Gui Jing: return lung, large intestine channel.

Function cures mainly: clearing heat and moistening lung, laxation relieving constipation.For lung-fire cough caused by dryness, pharyngalgia aphonia, dryness of the intestine constipation.

9, Fructus Perillae:

Nature and flavor: pungent, temperature.

Gui Jing: return lung meridian.

Function cures mainly: sending down the abnormal ascending QI expectorant, relievings asthma, intestine moistening.QI rising in reverse order is stopped up, cough and asthma, dryness of the intestine constipation for expectorant.

10, Rhizoma Imperatae:

Nature and flavor: sweet, cold.

Gui Jing: return lung, stomach, urinary bladder channel.

Function cures mainly: cooling blood for hemostasis, clearing away heat and promoting diuresis.Spit blood for heat in blood, epistaxis, hematuria, calentura excessive thirst, jaundice, edema, the puckery pain of pyretic stranguria; Acute nephritis edema.

11, Cuminum celery:

Nature and flavor: micro-acid, cool, pungent.

Cure mainly: sick for " Baconic ", lung heat syndrome, cold syndrome of the stomach abdominal distention, dyspepsia.

12, Radix Rehmanniae Preparata: be a kind of first-class Chinese crude drug, there is YIN nourishing effect of enriching blood, can be used for blood deficiency and yellow complexion, dizzy, palpitation and insomnia, menoxenia, the diseases such as metrorrhagia, also diseases such as can be used for hectic fever hectic fever due to YIN-deficiency, the night sweat of deficiency of kidney yin, pass out semen, quench one's thirst is one of deficiency syndrome class nonprescription drugs medicine LIUWEI DIHUANG WAN main component.

The property of medicine: sweet, tepor.Return liver, kidney channel.

Effect: yin nourishing of enriching blood, life essence-filling, marrow-benefitting.

13, Semen Armeniacae Amarum:

Nature and flavor: bitter, tepor; Slightly poisonous.

Effect: relieving cough and asthma, loosening bowel to relieve constipation.

14, Bulbus Lilii:

Nature and flavor: sweet; Micro-hardship; Be slightly cold.

Effect: the heart; Lung meridian.

15, Fructus Trichosanthis:

Nature and flavor: sweet, micro-hardship, cold.

Gui Jing: return lung, stomach, large intestine channel.

Function cures mainly: clearing away heat and eliminating phlegm, and relieving stuffiness of the chest by dispersing aggregation of pathogens moisturizes laxation.For cough due to lung-heat, the turbid Huang of expectorant is thick, obstruction of qi in the chest and cardialgia, blocked-up chest feeling of fullness, acute mastitis, lung abscess, and acute appendicitis swells and ache, constipation.

16, Herba Houttuyniae:

Nature and flavor: pungent, are slightly cold.

Gui Jing: return lung meridian.

Function cures mainly: heat-clearing and toxic substances removing, eliminating carbuncle evacuation of pus, inducing diuresis for treating stranguria syndrome.For lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, hematodiarrhoea, pyretic stranguria, carbuncle sore tumefacting virus.

17, Folium Eriobotryae:

Nature and flavor: bitter, are slightly cold.

Gui Jing: attach to the lung and stomach meridians.

Function cures mainly: clearing away lung-heat to relieve cough, stopping nausea and vomiting by lowering the adverse flow of QI.For cough due to lung-heat, QI rising in reverse order dyspnea with rapid respiration, gastric heat vomiting, dysphoria with smothery sensation is thirsty.

18, Fructus Rosae Laevigatae:

Nature and flavor: sour, sweet, puckery are flat.

Gui Jing: return kidney, bladder, large intestine channel.

Function cures mainly: controlling nocturnal emission with astringent drugs reducing urination, relieving diarrhea with astringents.For emission and spermatorrhea, enuresis frequent micturition, bleeding not during menses, chronic diarrhea chronic dysentery.

19, the Radix Rehmanniae:

Gui Jing: GUIXIN, liver, kidney channel.

Function cures mainly: Radix Rehmanniae: clearing away heat and promoting production of body fluid, removing heat from blood, hemostasis.For consumption of YIN caused by febrile disease, crimson tongue excessive thirst, sends out speckle dermexanthesis, spits blood, epistaxis, laryngopharynx swelling and pain.

20, Radix Glycyrrhizae:

Nature and flavor: sweet are flat.

Gui Jing: GUIXIN, lung, spleen, stomach warp.

Function cures mainly: invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.

21: Periostracum Cicadae:

Nature and flavor: sweet, cold.

Gui Jing: return lung, Liver Channel.

Function cures mainly: loose wind heat extraction, sore-throat relieving, rash, nebula removing, spasmolytic.For anemopyretic cold, pharyngalgia, hoarseness, measles without adequate eruption, rubella pruritus, cataract, convulsion with spasms, tetanus.

22: Herba Agrimoniae:

Nature and flavor: bitter, puckery are flat.

Gui Jing: GUIXIN, Liver Channel.

Function cures mainly: astringing to arrest bleeding, preventing the attack (or recurrence) of malaria, dysentery relieving, removing toxic substances.For hemoptysis, spit blood, metrostaxis, malaria, dysentery, de-power impairment caused by overstrain, carbuncle sore tumefacting virus, pudendal pruritus leukorrhagia.

23: Sargassum:

Nature and flavor: bitter, salty, cold.

Gui Jing: return liver, stomach, kidney channel.

Function cures mainly: hard masses softening and resolving, expectorant, diuretic.For goiter, scrofula, painful and swollen testis, phlegm retention edema.

24: Ramulus Uncariae Cum Uncis:

Nature and flavor: sweet are cool.

Gui Jing: return liver, pericardium channel.

Function cures mainly: heat clearing away suppressing the hyperactive liver, dispelling wind and relieving convulsion.Dizzy for having a headache, dysphoric cold, infantile convulsion is twitched, pre-eclampsia; Hypertension.

25: Caulis Spatholobi:

Nature and flavor: bitter, sweet, temperature.

Gui Jing: return liver, kidney channel.

Function cures mainly: enrich blood, and invigorates blood circulation, dredging collateral.For menoxenia, blood deficiency and yellow complexion, paralysis and numbness, rheumatic arthralgia.

26: Semen Raphani:

Nature and flavor: pungent, sweet are flat.

Gui Jing: return lung, spleen, stomach warp.

Function cures mainly: help digestion de-swelling, lowering the adverse-rising QI to resolve phlegm.For retention of food and drink, abdominal distention, constipation, stagnant dysentery, expectorant heap soil or fertilizer over and around the roots is breathed with cough.

Below by way of concrete preferred embodiment, the present invention is described in further detail, but the present invention is not limited in following embodiment.

embodiment 1

By Radix Platycodonis 3 parts; Flos Chrysanthemi 6 parts; Flos Lonicerae 5 parts; Radix Scutellariae 3 parts; Spica Prunellae 2 parts; Herba Menthae 2 parts; Bulbus Fritillariae Cirrhosae 5 parts; Fructus Momordicae 3 parts; Fructus Perillae 3 parts; Rhizoma Imperatae 2 parts; Cuminum celery 2 parts; 1 part, Radix Rehmanniae Preparata; 2 parts, Semen Armeniacae Amarum; Bulbus Lilii 2 parts; Fructus Trichosanthis 2 parts; Herba Houttuyniae 1 part; Folium Eriobotryae 10 parts; Fructus Rosae Laevigatae 1 part; 1 part, the Radix Rehmanniae; 5 parts, Radix Glycyrrhizae; Periostracum Cicadae 3 parts; Herba Agrimoniae 3 parts; Sargassum 6 parts; Ramulus Uncariae Cum Uncis 2 parts; Caulis Spatholobi 4 parts; Semen Raphani 5 parts.

The preparation method of the Chinese medicine composition of above-mentioned treatment bronchitis, comprise: the first step, described Chinese medicine composition is mixed in proportion, be placed in super micron mill and pulverize 30 minutes, Chinese medicine composition after pulverizing is dissolved in dehydrated alcohol and soaks 5 hours, add distilled water, ensure that concentration of alcohol is 60%, heating and refluxing extraction 4 times, filter, merging filtrate, vacuum decompression, obtain dry mastic, dry mastic described in vacuum drying, micronizing 10 minutes, powder after pulverizing is added the water dissolution relative to its quality 3 times amount, under agitation add relative to powder quality 5% ~ 20% sodium hydroxide hydrotropy, adjust ph is neutral, filter, adding concentration is that the salt acid for adjusting pH value of 15% is for acid, quiescent setting 10 hours, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 180 object fine powders,

When the dosage form of described pharmaceutical composition is oral liquid, described second step is specially, and adds the distilled water relative to its quality 3 times amount, the sucrose of 0.3 times in the powder that the first step obtains, the sodium benzoate of 0.01 times, stirs, boils, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

When the dosage form of described pharmaceutical composition is powder, described second step is specially, and adds the starch mix homogeneously relative to its quality 2 times, be prepared into powder in the powder that the first step obtains.

embodiment 2

By Radix Platycodonis 4 parts; Flos Chrysanthemi 7 parts; Flos Lonicerae 5 parts; Radix Scutellariae 3 parts; Spica Prunellae 3 parts; Herba Menthae 4 parts; Bulbus Fritillariae Cirrhosae 6 parts; Fructus Momordicae 3 parts; Fructus Perillae 4 parts; Rhizoma Imperatae 2 parts; Cuminum celery 2 parts; 2 parts, Radix Rehmanniae Preparata; 3 parts, Semen Armeniacae Amarum; Bulbus Lilii 3 parts; Fructus Trichosanthis 3 parts; Herba Houttuyniae 4 parts; Folium Eriobotryae 15 parts; Fructus Rosae Laevigatae 1 part; 2 parts, the Radix Rehmanniae; 6 parts, Radix Glycyrrhizae; Periostracum Cicadae 4 parts; Herba Agrimoniae 4 parts; Sargassum 7 parts; Ramulus Uncariae Cum Uncis 3 parts; Caulis Spatholobi 5 parts; Semen Raphani 10 parts.

embodiment 3

By Radix Platycodonis 5 parts; Flos Chrysanthemi 8 parts; Flos Lonicerae 10 parts; Radix Scutellariae 5 parts; Spica Prunellae 4 parts; Herba Menthae 5 parts; Bulbus Fritillariae Cirrhosae 8 parts; Fructus Momordicae 4 parts; Fructus Perillae 5 parts; Rhizoma Imperatae 3 parts; Cuminum celery 3 parts; 3 parts, Radix Rehmanniae Preparata; 4 parts, Semen Armeniacae Amarum; Bulbus Lilii 4 parts; Fructus Trichosanthis 5 parts; Herba Houttuyniae 5 parts; Folium Eriobotryae 20 parts; Fructus Rosae Laevigatae 2 parts; 3 parts, the Radix Rehmanniae; 10 parts, Radix Glycyrrhizae; Periostracum Cicadae 5 parts; Herba Agrimoniae 5 parts; Sargassum 8 parts; Ramulus Uncariae Cum Uncis 5 parts; Caulis Spatholobi 8 parts, Semen Raphani 6 parts.

Extracorporeal bacteria inhibitor test

For further illustrating the property of medicine of Chinese medicine composition of the present invention, carry out antibacterial experiment in vitro, and choose that white mice carries out cough-relieving, experiment of reducing phlegm, each laboratory mouse is 50, male and female half and half, random point five groups, often organizes ten.The experimental result obtained is as follows:

Antibacterial experiment in vitro is adopted to evaluate described Chinese medicine composition to the bacteriostatic or the killing action that cause respiratory tract infection in experiment.Totally 100 strains of 5 kinds of antibacterials are selected in this experiment, and comprise staphylococcus aureus, Klebsiella pneumoniae, bacillus pyocyaneus, staphylococcus epidermidis, each 20 strains of proteus vulgaris, above bacterial strain is Clinical isolation.Whole strain all carries out conventional method qualification, and it is that 1 × 105CFU/ml is for subsequent use that above-mentioned each bacterium is diluted to concentration respectively.Quality-control strains is staphylococcus aureus ATCC25922 and bacillus pyocyaneus ATCC27853.Adopt doubling dilution to be diluted respectively by this medicine distilled water according to the antibacterial effective range of prerun medicine and be mixed with final concentration.

Be respectively 0.8426,1.1962,2.84,7.1,11.9,30.15,58.31,120.3,231.1,469.3,929.7, the pastille agar plate culture medium of 1911.4g/ml, for subsequent use.More than operation is all carried out on aseptic operating platform.The bacterium liquid multiple spot diluted inoculation instrument is inoculated into respectively above-mentioned respectively containing the agar plate media surface of variable concentrations medicine, the pastille BAP culture medium of beta hemolytic streptococcus containing 10% defiber Sanguis caprae seu ovis, cultivate 18h, be the minimal inhibitory concentration (MIC) of this medicine without the least concentration of contained drug in the plate of bacterial growth for 37 DEG C.The results are shown in Table 1, in tested 5 kind of 100 strain clinical strains, result shows, the effect of this Chinese medicine composition to staphylococcus aureus, staphylococcus epidermidis and klebsiella pneumoniae is stronger, illustrate that this medicine has the antibacterial playing respiratory tract infection to suppress preferably or killing action, have certain inhibitory action to proteus vulgaris and bacillus pyocyaneus.As shown in Table 1, this medicine also has good inhibitory action to 2 strain Quality-control strains.

Kind	Strain number	MIC (g crude drug/ml)
			Staphylococcus aureus	20	6.7
Staphylococcus epidermidis	20	14.3
			Bacillus pyocyaneus	20	116.8
Klebsiella pneumoniae	20	13.1
			Proteus vulgaris	20	136.2
Staphylococcus aureus ATCC25922	1	3.94
			Bacillus pyocyaneus ATCC27853	1	7.4

Cough-relieving is tested

By strong aqua ammonia nebulization, evaluate the antitussive action of this medicine.White mice divides 5 groups, i.e. normal saline group, drug control group, each one group of this Medications Example 1, embodiment 2, embodiment 3, continuous gastric infusion 3d, drug control group adopts ZHENKELING 6.2ml/kg administration, after 3d administration 30min, white mice is put in 1000ml closed glass container, spray into ammonia with ultrasound atomizer and excite white mice to cough, occur contraction of abdominal muscle with white mice simultaneously, contracting breast, opening one's mouth, is cough standard, and record draws coughs white mice cough number of times in incubation period and 5min.The results are shown in Table two, this Medications Example 1, embodiment 2, embodiment 3 all can make that white mice cough latent period obviously extends, number of times of coughing obviously reduces, all there is statistical significance with blank group comparing difference, and in certain dose-effect relationship, show that this medicine has good antitussive action.

The beneficial effect that the present invention treats the Chinese medicine of pneumonia is set forth further below by way of experimental example.

Subject Population: be divided into A, B two experimental grouies:

A group: bronchitis male patient 126 example; 10 ~ 80 years old age.

B group: bronchitis female patient 74 example; 10 ~ 80 years old age.

2, drug administration method:

Chinese medicine every day of the treatment pneumonia that the oral embodiment of the present invention 3 is obtained 3 times, serve on 3 days.

3, efficacy evaluation:

(1) invalid: compared with before taking medicine, without significant change.

(2) effective: to cure

Model case:

Case 1 Liu 53

Symptom: occur cough, expectoration after suffering from cold before 10 years, cough as discontinuity, more acutely, expectorant is the sticky expectorant of white, and amount is many, not easily expectoration, transference cure after treatment, after this annual often outbreak, more than March persistent period, all transference cures after treatment.Over nearly 5 days, above-mentioned symptom increases the weight of, and without nausea and vomiting, no headache, without blurred vision, blindness and faint, without chest pain, the symptom such as uncomfortable in chest, treats, Jin Telaiwo institute hospitalization, be diagnosed as " chronic bronchitis-acute attack ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 8 days, symptom is alleviated, and after taking medicine 15 days, symptom is obviously improved, and after taking 22 days, patient returns to one's perfect health.

Case 2 Zhang 43

Symptom: patient does after farm work is suffered from cold and occurs cough, expectoration under 3 days causes, normal companion's pharyngalgia, shed tears, hypogeusia, hypopnea, without Nausea and vomiting, without uncomfortable in chest, breathe hard, without abdominal distention, stomachache and diarrhoea, recently above-mentioned symptom increases the weight of, and Jin Telaiwo institute hospitalization, is diagnosed as " upper respiratory tract infection ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 4 days, symptom is alleviated, and after taking medicine 8 days, symptom is obviously improved, and after taking 13 days, patient returns to one's perfect health.

Case 3 Zheng 58

Symptom: patient often occurs cough, expectoration in before 20 years after suffering from cold, expectorant is white foam sample, outbreak 2-3 time time cold more than Winter-Spring, and each outbreak continues about 1-2 month, can take a turn for the better after oral anti-inflammatory drug (specifically not quite clear) voluntarily, not give enough attention.In before 5 years, cough, expectoration increase the weight of gradually, annual outbreak continues more than 2 months, sooner or later outstanding acute, amount of expectoration is many, is white foam sample, is yellow purulent sputum sometimes, and gradually occur stair climbing, breathe hard when to do physical labor etc., but daily life still can be taken care of oneself, Jin Telaiwo institute hospitalization, is diagnosed as " chronic bronchitis ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 7 days, symptom is alleviated, and after taking medicine 16 days, symptom is obviously improved, and after taking 25 days, patient returns to one's perfect health.

Case 4 Qin so-and-so 46

Symptom: patient occurred cough, expectoration, with tachypnea, without chest pain, without Nausea and vomiting without obvious inducement before 2 years.Without heating, without edema of pair of lower extremities.Can take a turn for the better after oral anti-inflammatory drug (specifically not quite clear) voluntarily, within nearly 1 week, carry out patient and after field work flu is suffered from cold, again occur cough, expectoration, tachypnea, weakly to increase the weight of, Jin Telaiwo institute hospitalization, is diagnosed as " chronic bronchitis ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 5 days, symptom is alleviated, and after taking medicine 9 days, symptom is obviously improved, and after taking 14 days, patient returns to one's perfect health.

Case 5 king so-and-so 30

Symptom: patient is rear in this morning to start to occur fear of cold without obvious inducement, heating, body temperature 39 DEG C of testing oneself, without perspiring, then go out pharyngalgia, tic of the limbs, show effect in paroxysmal, each outbreak continues about about 15 seconds, without cough, expectoration, without malaise symptoms such as Nausea and vomiting, the diagnosis and treatment of non-row system, for asking further system diagnosis and treatment, Jin Telaiwo institute hospitalization, is diagnosed as " upper respiratory tract infection ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 2 days, symptom is alleviated, and after taking medicine 4 days, symptom is obviously improved, and after taking 7 days, patient returns to one's perfect health.

Case 6 Liu so-and-so 27

Symptom: before two days, snivel after catching a cold, nose hinders, headache and dizziness, general pain, malaise, and tending to vomit of feeling sick, then coughing, is paroxysmal dry cough, and without expectorant, above-mentioned exacerbation of symptoms before 1 day, cough and expectoration, expectorant not easily brings up.Generate heat 38.5 ~ 39.5 DEG C, accompany slight tachypnea simultaneously.Spiritual appetite is gradually poor after being ill, and after heating, yellowish urine amount is few, stool every day 1 time, without asthma, and hoarseness, also without symptoms such as night sweat, spitting of blood, frequent micturition, ears pyorrheas.Without vomiting, diarrhoea and tic, Jin Telaiwo institute hospitalization, is diagnosed as " upper respiratory tract infection ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 3 days, symptom is alleviated, and after taking medicine 6 days, symptom is obviously improved, and after taking 10 days, patient returns to one's perfect health.

Case 7 chaste tree so-and-so 66

Symptom: before 5 years, patient occurs the symptoms such as cough, expectoration after suffering from cold, with panting, the medium and thickness of amount of expectoration, taking antiinflammatory antitussive can alleviate, after this 5 years there is above-mentioned symptom in interruption, occur more than winter-spring season, cough obvious to rise morning with night, cough the sticky expectorant of white, time have amount of expectoration to increase, sputum retrogradation is in yellow, annual outbreak 3 ~ 4 months, Jin Telaiwo institute hospitalization, is diagnosed as " chronic bronchitis ".

Therapeutic process: take powder of the present invention every day, each 2 bags, every day 3 times.After taking medicine 7 days, symptom is alleviated, and after taking medicine 11 days, symptom is obviously improved, and after taking 20 days, patient returns to one's perfect health

The above, it is only preferred embodiment of the present invention, not any pro forma restriction is done to the present invention, therefore everyly do not depart from technical solution of the present invention content, the any simple modification done above embodiment according to technical spirit of the present invention, equivalent variations and modification, all still belong in the scope of technical solution of the present invention.

Claims

1. treat a Chinese medicine composition for bronchitis, it is characterized in that: be made up of each component of following parts by weight:

2. the Chinese medicine composition for the treatment of bronchitis according to claim 1, is characterized in that: be made up of each component of following parts by weight:

3. the Chinese medicine composition for the treatment of bronchitis according to claim 1, is characterized in that: be made up of each component of following parts by weight:

4. the Chinese medicine composition of the treatment bronchitis according to any one of claim 1-3, is characterized in that: in described Chinese medicine composition, can add Semen Raphani further, and the addition in described Chinese medicine composition is 1-20 part.

5. the Chinese medicine composition of the treatment bronchitis according to any one of claim 1-3, is characterized in that: in described Chinese medicine composition, can add Semen Raphani further, and the addition in described Chinese medicine composition is 5-15 part.

6. the preparation method of the Chinese medicine composition for the treatment of bronchitis according to claim 1, is characterized in that: described Chinese medicine composition is prepared into powder, oral liquid.

7. the preparation method of the Chinese medicine composition for the treatment of bronchitis according to claim 6, it is characterized in that: comprise the following steps: the first step, described Chinese medicine composition is mixed in proportion, be placed in super micron mill and pulverize 10 minutes ~ 60 minutes, Chinese medicine composition after pulverizing is dissolved in dehydrated alcohol and soaks 2 ~ 5 hours, add distilled water, ensure that concentration of alcohol is 60% ~ 90%, reflux I extract 2 ~ 5 times, filter, merging filtrate, vacuum decompression, obtain dry mastic, dry mastic described in vacuum drying, micronizing 10 minutes ~ 30 minutes, powder after pulverizing is added the water dissolution relative to its quality 1 ~ 6 times amount, under agitation add relative to powder quality 5% ~ 20% sodium hydroxide hydrotropy, adjust ph is neutral, filter, adding concentration is that the salt acid for adjusting pH value of 15% is for acid, quiescent setting 1 ~ 12 hour, filter, filtrate alcohol extraction, extract concentrating under reduced pressure becomes dry mastic, dry subsequently, be ground into 100 order ~ 180 object fine powders,

8. the preparation method of the Chinese medicine composition for the treatment of bronchitis as claimed in claim 6, it is characterized in that: when the dosage form of described pharmaceutical composition is oral liquid, described second step is specially, in the powder that the first step obtains, add the distilled water relative to its quality 1 ~ 3 times amount, the sucrose of 0.1 ~ 0.3 times, the sodium benzoate of 0.01 ~ 0.05 times, stirs, boils, cooling, filter, subpackage, namely sterilizing obtains oral liquid.

9. the preparation method of the Chinese medicine composition for the treatment of bronchitis as claimed in claim 6, it is characterized in that: when the dosage form of described pharmaceutical composition is powder, described second step is specially, in the powder that the first step obtains, add the starch mix homogeneously relative to its quality 1 ~ 5 times, be prepared into powder.