CN104524215A - Capsules for treating stomach diseases and preparation method thereof - Google Patents
Capsules for treating stomach diseases and preparation method thereof Download PDFInfo
- Publication number
- CN104524215A CN104524215A CN201410831232.1A CN201410831232A CN104524215A CN 104524215 A CN104524215 A CN 104524215A CN 201410831232 A CN201410831232 A CN 201410831232A CN 104524215 A CN104524215 A CN 104524215A
- Authority
- CN
- China
- Prior art keywords
- parts
- bletillae
- rhizoma
- capsule
- gastropathy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002775 capsule Substances 0.000 title claims abstract description 74
- 208000018556 stomach disease Diseases 0.000 title claims abstract description 70
- 238000002360 preparation method Methods 0.000 title claims abstract description 21
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 47
- 241000180649 Panax notoginseng Species 0.000 claims abstract description 47
- 208000012895 Gastric disease Diseases 0.000 claims description 66
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 49
- 239000000843 powder Substances 0.000 claims description 39
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 30
- 238000000638 solvent extraction Methods 0.000 claims description 21
- 239000012141 concentrate Substances 0.000 claims description 10
- 239000006071 cream Substances 0.000 claims description 9
- 238000002156 mixing Methods 0.000 claims description 5
- 239000002904 solvent Substances 0.000 claims description 4
- 238000005469 granulation Methods 0.000 claims description 3
- 230000003179 granulation Effects 0.000 claims description 3
- 230000000694 effects Effects 0.000 abstract description 34
- 210000002784 stomach Anatomy 0.000 abstract description 20
- 208000002193 Pain Diseases 0.000 abstract description 19
- 230000001737 promoting effect Effects 0.000 abstract description 16
- 208000007882 Gastritis Diseases 0.000 abstract description 15
- 239000008280 blood Substances 0.000 abstract description 15
- 210000004369 blood Anatomy 0.000 abstract description 15
- 230000017531 blood circulation Effects 0.000 abstract description 15
- 230000000740 bleeding effect Effects 0.000 abstract description 11
- 208000023652 chronic gastritis Diseases 0.000 abstract description 8
- 230000002496 gastric effect Effects 0.000 abstract description 8
- 231100000957 no side effect Toxicity 0.000 abstract description 6
- 208000000718 duodenal ulcer Diseases 0.000 abstract description 5
- 230000008961 swelling Effects 0.000 abstract description 5
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 2
- 241000271309 Aquilaria crassna Species 0.000 abstract 1
- 241001313855 Bletilla Species 0.000 abstract 1
- 241000037740 Coptis chinensis Species 0.000 abstract 1
- 241000935235 Fritillaria meleagris Species 0.000 abstract 1
- 201000005917 gastric ulcer Diseases 0.000 abstract 1
- 229960004756 ethanol Drugs 0.000 description 22
- 238000000605 extraction Methods 0.000 description 18
- 241000700159 Rattus Species 0.000 description 14
- 238000009835 boiling Methods 0.000 description 13
- 201000010099 disease Diseases 0.000 description 12
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 12
- 208000016644 chronic atrophic gastritis Diseases 0.000 description 11
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 10
- 239000003814 drug Substances 0.000 description 10
- 238000005325 percolation Methods 0.000 description 9
- 238000012360 testing method Methods 0.000 description 9
- 208000032843 Hemorrhage Diseases 0.000 description 8
- 235000009508 confectionery Nutrition 0.000 description 8
- 230000000968 intestinal effect Effects 0.000 description 8
- STZCRXQWRGQSJD-GEEYTBSJSA-M methyl orange Chemical compound [Na+].C1=CC(N(C)C)=CC=C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-GEEYTBSJSA-M 0.000 description 7
- 229940012189 methyl orange Drugs 0.000 description 7
- 208000024891 symptom Diseases 0.000 description 7
- 206010062717 Increased upper airway secretion Diseases 0.000 description 6
- 239000000706 filtrate Substances 0.000 description 6
- 238000001914 filtration Methods 0.000 description 6
- 208000026435 phlegm Diseases 0.000 description 6
- 239000007787 solid Substances 0.000 description 6
- 238000002835 absorbance Methods 0.000 description 5
- 229910021529 ammonia Inorganic materials 0.000 description 5
- 229940079593 drug Drugs 0.000 description 5
- 239000008187 granular material Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 5
- 210000000952 spleen Anatomy 0.000 description 5
- 206010011224 Cough Diseases 0.000 description 4
- 208000000616 Hemoptysis Diseases 0.000 description 4
- 206010022714 Intestinal ulcer Diseases 0.000 description 4
- 102000057297 Pepsin A Human genes 0.000 description 4
- 108090000284 Pepsin A Proteins 0.000 description 4
- 206010040007 Sense of oppression Diseases 0.000 description 4
- 238000009825 accumulation Methods 0.000 description 4
- 239000000284 extract Substances 0.000 description 4
- 230000006870 function Effects 0.000 description 4
- 210000004051 gastric juice Anatomy 0.000 description 4
- 238000003304 gavage Methods 0.000 description 4
- 229940111202 pepsin Drugs 0.000 description 4
- 230000035807 sensation Effects 0.000 description 4
- 235000019615 sensations Nutrition 0.000 description 4
- 230000004206 stomach function Effects 0.000 description 4
- 239000003053 toxin Substances 0.000 description 4
- 231100000765 toxin Toxicity 0.000 description 4
- 238000010792 warming Methods 0.000 description 4
- 241000699670 Mus sp. Species 0.000 description 3
- 208000007536 Thrombosis Diseases 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 230000030136 gastric emptying Effects 0.000 description 3
- 230000007774 longterm Effects 0.000 description 3
- 231100000614 poison Toxicity 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 231100000331 toxic Toxicity 0.000 description 3
- 230000002588 toxic effect Effects 0.000 description 3
- 230000036228 toxication Effects 0.000 description 3
- 206010007247 Carbuncle Diseases 0.000 description 2
- 206010051625 Conjunctival hyperaemia Diseases 0.000 description 2
- 206010010726 Conjunctival oedema Diseases 0.000 description 2
- 241000699666 Mus <mouse, genus> Species 0.000 description 2
- 206010040943 Skin Ulcer Diseases 0.000 description 2
- 206010040849 Skin fissures Diseases 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- 206010053615 Thermal burn Diseases 0.000 description 2
- 206010053476 Traumatic haemorrhage Diseases 0.000 description 2
- 206010061577 Ulcer haemorrhage Diseases 0.000 description 2
- 206010047700 Vomiting Diseases 0.000 description 2
- 230000009858 acid secretion Effects 0.000 description 2
- 230000000202 analgesic effect Effects 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 235000019636 bitter flavor Nutrition 0.000 description 2
- 230000037396 body weight Effects 0.000 description 2
- 230000001684 chronic effect Effects 0.000 description 2
- 208000037976 chronic inflammation Diseases 0.000 description 2
- 208000037893 chronic inflammatory disorder Diseases 0.000 description 2
- 238000007598 dipping method Methods 0.000 description 2
- 208000001848 dysentery Diseases 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 208000001780 epistaxis Diseases 0.000 description 2
- 230000003203 everyday effect Effects 0.000 description 2
- 210000004211 gastric acid Anatomy 0.000 description 2
- 230000002607 hemopoietic effect Effects 0.000 description 2
- 208000014617 hemorrhoid Diseases 0.000 description 2
- 201000007227 lymph node tuberculosis Diseases 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 231100000915 pathological change Toxicity 0.000 description 2
- 230000036285 pathological change Effects 0.000 description 2
- 208000008128 pulmonary tuberculosis Diseases 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 230000001105 regulatory effect Effects 0.000 description 2
- 230000028327 secretion Effects 0.000 description 2
- 206010040872 skin infection Diseases 0.000 description 2
- 231100000019 skin ulcer Toxicity 0.000 description 2
- 238000002560 therapeutic procedure Methods 0.000 description 2
- 210000001519 tissue Anatomy 0.000 description 2
- 238000009423 ventilation Methods 0.000 description 2
- 230000008673 vomiting Effects 0.000 description 2
- 206010003591 Ataxia Diseases 0.000 description 1
- 206010010947 Coordination abnormal Diseases 0.000 description 1
- 238000012449 Kunming mouse Methods 0.000 description 1
- 208000005718 Stomach Neoplasms Diseases 0.000 description 1
- 210000001015 abdomen Anatomy 0.000 description 1
- 230000005856 abnormality Effects 0.000 description 1
- 230000007059 acute toxicity Effects 0.000 description 1
- 231100000403 acute toxicity Toxicity 0.000 description 1
- 210000003484 anatomy Anatomy 0.000 description 1
- 230000004596 appetite loss Effects 0.000 description 1
- 238000012742 biochemical analysis Methods 0.000 description 1
- 229940126678 chinese medicines Drugs 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229960000935 dehydrated alcohol Drugs 0.000 description 1
- 210000002249 digestive system Anatomy 0.000 description 1
- 239000012153 distilled water Substances 0.000 description 1
- 230000035622 drinking Effects 0.000 description 1
- 206010017758 gastric cancer Diseases 0.000 description 1
- 208000016290 incoordination Diseases 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 230000003908 liver function Effects 0.000 description 1
- 231100001252 long-term toxicity Toxicity 0.000 description 1
- 235000021266 loss of appetite Nutrition 0.000 description 1
- 208000019017 loss of appetite Diseases 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 210000000713 mesentery Anatomy 0.000 description 1
- 230000004089 microcirculation Effects 0.000 description 1
- 239000002547 new drug Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 230000003285 pharmacodynamic effect Effects 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 238000010298 pulverizing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229910000030 sodium bicarbonate Inorganic materials 0.000 description 1
- 235000017557 sodium bicarbonate Nutrition 0.000 description 1
- STZCRXQWRGQSJD-UHFFFAOYSA-M sodium;4-[[4-(dimethylamino)phenyl]diazenyl]benzenesulfonate Chemical compound [Na+].C1=CC(N(C)C)=CC=C1N=NC1=CC=C(S([O-])(=O)=O)C=C1 STZCRXQWRGQSJD-UHFFFAOYSA-M 0.000 description 1
- 201000011549 stomach cancer Diseases 0.000 description 1
- 239000006228 supernatant Substances 0.000 description 1
- 238000002636 symptomatic treatment Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- 230000002110 toxicologic effect Effects 0.000 description 1
- 231100000027 toxicology Toxicity 0.000 description 1
- 238000002562 urinalysis Methods 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/898—Orchidaceae (Orchid family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/83—Thymelaeaceae (Mezereum family), e.g. leatherwood or false ohelo
- A61K36/835—Aquilaria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8966—Fritillaria, e.g. checker lily or mission bells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1664—Compounds of unknown constitution, e.g. material from plants or animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicines Containing Plant Substances (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention discloses capsules for treating stomach diseases and a preparation method thereof. The capsules for treating the stomach diseases comprise the following components in parts by weight: 10-60 parts of common bletilla pseudobulb, 2-30 parts of bulb of thunberg fritillary, 1-10 parts of Chinese eaglewood, 1-10 parts of panax notoginseng and 2-30 parts of coptis chinensis. The capsules for treating the stomach diseases, disclosed by the invention, have significant effects on promoting blood circulation and relieving pain, astringing and stopping bleeding, and resisting stomach ulcers and gastritis, and have the characteristics of quick curative effect, high cure rate, no side effects and the like in treating chronic gastritis, stomach heat and phlegmatic mass, blood stasis and qi stagnancy, gastric cavity swelling pain, stomach ulcer and duodenal ulcer.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of capsule for the treatment of gastropathy and preparation method thereof.
Background technology
Gastropathy comprises chronic gastritis, gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach burst intestinal and duodenal ulcer etc., wherein chronic gastritis is divided into chronic superficial gastritis and chronic atrophic gastritis, chronic superficial gastritis develops into severe stage, is chronic atrophic gastritis.Chronic atrophic gastritis is digestive system commonly encountered diseases, the frequently-occurring disease of comparatively obstinate refractory, is easily converted into gastric cancer.The cause of disease of current chronic gastritis is not yet illustrated, and therefore modern medicine only takes local symptomatic treatment or operative treatment targetedly.Therefore, the Chinese medicine of exploitation treatment gastropathy has very important significance.
Summary of the invention
Based on this, be necessary to provide capsule of the treatment gastropathy that a kind of curative effect is fast, cure rate is high and preparation method thereof.
Treat a capsule for gastropathy, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
Wherein in an embodiment, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 45 parts, Bulbus Fritillariae Thunbergii 2 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts and Rhizoma Coptidis 2 ~ 20 parts.
Wherein in an embodiment, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 ~ 45 parts, Bulbus Fritillariae Thunbergii 8 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 8 parts, Radix Notoginseng 4 ~ 8 parts and Rhizoma Coptidis 8 ~ 20 parts.
Treat a preparation method for the capsule of gastropathy, comprise the steps:
The Rhizoma Coptidis of the Pseudobulbus Bletillae (Rhizoma Bletillae) of 10 ~ 60 parts, the Bulbus Fritillariae Thunbergii of 2 ~ 30 parts, the Lignum Aquilariae Resinatum of 1 ~ 10 part, the Radix Notoginseng of 1 ~ 10 part and 2 ~ 30 parts is pulverized and/or with solvent extraction, makes capsule.
Wherein in an embodiment, comprise the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned mass parts is pulverized/use solvent extraction, obtain Rhizoma Bletillae powder and/or Pseudobulbus Bletillae (Rhizoma Bletillae) cream;
The Lignum Aquilariae Resinatum of above-mentioned mass parts is pulverized, obtains Lignum Aquilariae Resinatum powder;
The Radix Notoginseng of above-mentioned mass parts is pulverized, obtains Radix Notoginseng powder;
By the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction, obtain clear paste; And
By described Rhizoma Bletillae powder and/or the mixing of Pseudobulbus Bletillae (Rhizoma Bletillae) cream, Lignum Aquilariae Resinatum powder, Radix Notoginseng powder and clear paste, make capsule.
Wherein in an embodiment, following steps: the Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion is divided into first part and second part totally two parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of first part is pulverized and obtains Rhizoma Bletillae powder, by the Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction of second part, concentrate and obtain Pseudobulbus Bletillae (Rhizoma Bletillae) cream, by the Bulbus Fritillariae Thunbergii of described Rhizoma Bletillae powder, described Pseudobulbus Bletillae (Rhizoma Bletillae) cream and above-mentioned weight portion, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis mixing, make capsule.
Wherein in an embodiment, the Pseudobulbus Bletillae (Rhizoma Bletillae) of described first part and the Pseudobulbus Bletillae (Rhizoma Bletillae) weight ratio of described second part are 1 ~ 2:1.
Wherein in an embodiment, described solvent is at least one of water and ethanol.
Wherein in an embodiment, comprise the steps:, by the Rhizoma Coptidis solvent extraction of the Pseudobulbus Bletillae (Rhizoma Bletillae) of 10 ~ 60 parts, the Bulbus Fritillariae Thunbergii of 2 ~ 30 parts, the Lignum Aquilariae Resinatum of 1 ~ 10 part, the Radix Notoginseng of 1 ~ 10 part and 2 ~ 30 parts, to obtain concentrate, obtain the capsule of described treatment gastropathy.
Wherein in an embodiment, describedly the Rhizoma Coptidis of the Pseudobulbus Bletillae (Rhizoma Bletillae) of 10 ~ 60 parts, the Bulbus Fritillariae Thunbergii of 2 ~ 30 parts, the Lignum Aquilariae Resinatum of 1 ~ 10 part, the Radix Notoginseng of 1 ~ 10 part and 2 ~ 30 parts to be pulverized and/or with after solvent extraction, comprise step: dry, pulverize granulate encapsulated, obtain the capsule of described treatment gastropathy.
The capsule that the present invention treats gastropathy is based on theory of Chinese medical science, and in conjunction with clinical practice, what filter out from Chinese medicine material treasure-house a series ofly has promoting blood circulation and stopping pain, the Chinese crude drug of astringing to arrest bleeding effect.Wherein, Pseudobulbus Bletillae (Rhizoma Bletillae), property is bitter, sweet to be slightly cold, and has astringing to arrest bleeding, effect of detumescence and promoting granulation, spits blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin, pulmonary tuberculosis hemoptysis, the diseases such as ulcer haemorrhage and the external such as skin infection, burn and scald; Bulbus Fritillariae Thunbergii hardship is sweet, is slightly cold, and has effect of hemostasisization disease, for cough due to lung-heat, and heat clearing away eliminating stagnation, the disease such as scrofula and carbuncle; Lignum Aquilariae Resinatum, there is strong antibacterial efficacy and clear god regulates the flow of vital energy, tonifying five ZANG-organs, relieving cough and resolving phlegm, warming the stomach warming the spleen, ventilation analgesic therapy effect; Radix Notoginseng, the sweet mildly bitter flavor of property, warm in nature, can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Rhizoma Coptidis, sweet in the mouth cold nature, has effect of relieving heat toxin, and irritated for calentura, mouth tells raw skin ulcer, spits blood, epistaxis, the diseases such as conjunctival congestion and swelling pain, dysentery hemorrhoid, gastropyretic vomiting.The present invention treats the drug component of the capsule of gastropathy through dialectical compatibility, complements each other using, has synergism, play promoting blood circulation and stopping pain altogether, the effects such as astringing to arrest bleeding.The capsule of above-mentioned treatment gastropathy has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach to burst intestinal, gastritis effect, be used for the treatment of chronic gastritis, gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach is burst intestinal and duodenal ulcer, has the features such as curative effect is fast, cure rate is high and have no side effect.
Detailed description of the invention
For the ease of understanding the present invention, below the present invention is described more fully, and gives preferred embodiment of the present invention.But the present invention can realize in many different forms, is not limited to embodiment described herein.On the contrary, provide the object of these embodiments be make the understanding of disclosure of the present invention more comprehensively thorough.
Unless otherwise defined, all technology used herein and scientific terminology are identical with belonging to the implication that those skilled in the art of the present invention understand usually.The object of term used in the description of the invention herein just in order to describe specific embodiment, is not intended to be restriction the present invention.Term as used herein " and/or " comprise arbitrary and all combinations of one or more relevant Listed Items.
Treat a capsule for gastropathy, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
Especially, described Rhizoma Coptidis is Fructus Evodiae Rhizoma Coptidis (processed).Rhizoma Coptidis bitter cold injures one's stomach, and Fructus Evodiae is hot in nature, so can alleviate the cold of Rhizoma Coptidis after Fructus Evodiae Rhizoma Coptidis (parched), Rhizoma Coptidis like this is cold then can not imapirment of the spleen and stomach.
Preferably, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 45 parts, Bulbus Fritillariae Thunbergii 2 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts and Rhizoma Coptidis 2 ~ 20 parts.
Preferred, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 ~ 45 parts, Bulbus Fritillariae Thunbergii 8 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 8 parts, Radix Notoginseng 4 ~ 8 parts and Rhizoma Coptidis 8 ~ 20 parts.
The capsule that the present invention treats gastropathy is based on theory of Chinese medical science, and in conjunction with clinical practice, what filter out from Chinese medicine material treasure-house a series ofly has promoting blood circulation and stopping pain, the Chinese crude drug of astringing to arrest bleeding effect.
Wherein, Pseudobulbus Bletillae (Rhizoma Bletillae), property is bitter, sweet to be slightly cold, and has astringing to arrest bleeding, effect of detumescence and promoting granulation, spits blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin, pulmonary tuberculosis hemoptysis, the diseases such as ulcer haemorrhage and the external such as skin infection, burn and scald.
Bulbus Fritillariae Thunbergii hardship is sweet, is slightly cold, and has effect of hemostasisization disease, for cough due to lung-heat, and heat clearing away eliminating stagnation, the disease such as scrofula and carbuncle.
Lignum Aquilariae Resinatum, there is strong antibacterial efficacy and clear god regulates the flow of vital energy, tonifying five ZANG-organs, relieving cough and resolving phlegm, warming the stomach warming the spleen, ventilation analgesic therapy effect.
Radix Notoginseng, the sweet mildly bitter flavor of property, warm in nature, can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function.
Rhizoma Coptidis, sweet in the mouth cold nature, has effect of relieving heat toxin, and irritated for calentura, mouth tells raw skin ulcer, spits blood, epistaxis, the diseases such as conjunctival congestion and swelling pain, dysentery hemorrhoid, gastropyretic vomiting.
The present invention treats the drug component of the capsule of gastropathy through dialectical compatibility, complements each other using, has synergism, play promoting blood circulation and stopping pain altogether, the effects such as astringing to arrest bleeding.The capsule of above-mentioned treatment gastropathy has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach to burst intestinal, gastritis effect, be used for the treatment of chronic gastritis, gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach is burst intestinal and duodenal ulcer, has the features such as curative effect is fast, cure rate is high and have no side effect.
The preparation method of the capsule of above-mentioned treatment gastropathy, comprises the steps:
S1: the Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion is divided into two parts, pulverizes a copy of it Pseudobulbus Bletillae (Rhizoma Bletillae) and obtains Rhizoma Bletillae powder, by another part of Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction, concentrates and obtains Pseudobulbus Bletillae (Rhizoma Bletillae) cream.
Especially, Rhizoma Bletillae powder was broken to 100 mesh sieves.Especially, the Pseudobulbus Bletillae (Rhizoma Bletillae) being used for pulverizing is 1 ~ 2:1 with the weight ratio of the Pseudobulbus Bletillae (Rhizoma Bletillae) for extracting, and is preferably 1:1.
Especially, solvent is selected from least one in water and ethanol.Be water boiling and extraction method, alcohol dipping extraction method or ethanol percolate extraction method by the method for the Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction of second part.
Preferably, be water boiling and extraction method by the method for the Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction of second part, and take twice step by step arithmetic.First time extracts, and obtains the first filtrate and the first filtering residue, the first filtering residue is carried out second time and extracts, filter and obtain the second filtrate and the second filtering residue, merge the first filtrate and the second filtrate.
First time extracts: the amount adding water is 4 ~ 10 times of the Pseudobulbus Bletillae (Rhizoma Bletillae) quality of second part, and the time of extraction clocks from water boiling, is 0.5 ~ 2 hour.Preferably, the amount adding water is 7 times of the Pseudobulbus Bletillae (Rhizoma Bletillae) quality of second part, and the time of extraction clocks from water boiling, is 1 hour.
Second time is extracted: the amount adding water is 4 ~ 10 times of the Pseudobulbus Bletillae (Rhizoma Bletillae) quality of second part, and the time of extraction clocks from water boiling, is 0.5 ~ 2 hour.Preferably, the amount adding water is 6 times of the Pseudobulbus Bletillae (Rhizoma Bletillae) quality of second part, and the time of extraction clocks from water boiling, is 1 hour.
S2: the Lignum Aquilariae Resinatum of above-mentioned mass parts is pulverized, obtains Lignum Aquilariae Resinatum powder.
Especially, Lignum Aquilariae Resinatum was crushed to 100 mesh sieves.
S3: the Radix Notoginseng of above-mentioned mass parts is pulverized, obtains Radix Notoginseng powder.
Especially, Radix Notoginseng powder was broken to 100 mesh sieves.
S4: by the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction, obtain clear paste.
Especially, solvent is selected from least one in water and ethanol.The method extracted is water boiling and extraction method, alcohol dipping extraction method or ethanol percolate extraction method.
Preferably, be ethanol percolate extraction method by the method for the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction.Especially, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are added ethanol and carries out percolation, collect percolate, when percolate is without color, stop percolation, percolate is concentrated, the capsule of the gastropathy that namely obtains medical treatment.Especially, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are added ethanol and carry out percolation step and also obtain filtering residue, filtering residue is squeezed, obtains pressed liquor, pressed liquor and percolate are merged, concentrates.Be appreciated that and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis can be extracted separately.
Especially, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 5 ~ 8:2 ~ 5, and makes ethanol submergence medicated powder surface all the time.Preferred, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 7:3.Wherein, described ethanol is dehydrated alcohol.
S5: Rhizoma Bletillae powder, Lignum Aquilariae Resinatum powder, Radix Notoginseng powder and clear paste are mixed.
S6: by Rhizoma Bletillae powder, Lignum Aquilariae Resinatum powder, Radix Notoginseng powder and clear paste mix after, dry, pulverize granulate encapsulated, obtain the capsule of described treatment gastropathy.
Be appreciated that step S1 can omit, Pseudobulbus Bletillae (Rhizoma Bletillae) all carried out pulverize or all use solvent extraction, obtain extracting solution or concentrate, carry out step S5.Step S2 can omit, and by Lignum Aquilariae Resinatum solvent extraction, obtains extracting solution or concentrate, carries out step S5.Step S3 can omit, and by Radix Notoginseng solvent extraction, obtains extracting solution or concentrate, carries out step S5.By step S4 solvent extraction, extracting solution can be obtained, directly carry out step S5.Step S4 can omit, and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis is pulverized, carries out step S5.Step S6 can omit, and directly Rhizoma Bletillae powder, Lignum Aquilariae Resinatum powder, Radix Notoginseng powder and clear paste is mixed.
Be appreciated that and can not adopt above-mentioned preparation method, Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are pulverized, the capsule of the gastropathy that obtains medical treatment; Or Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are extracted, the capsule of the gastropathy that obtains medical treatment.
The preparation method of the capsule of above-mentioned treatment gastropathy, method is simple to operation, take full advantage of the effective ingredient of raw material, maximally utilised raw material, the capsule of the treatment gastropathy prepared has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach to burst intestinal, gastritis effect, is used for the treatment of chronic gastritis, gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach is burst intestinal and duodenal ulcer, has the features such as curative effect is fast, cure rate is high and have no side effect.
It is below specific embodiment.
Embodiment 1
A kind of capsule for the treatment of gastropathy of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 35 parts, Bulbus Fritillariae Thunbergii 20 parts, Lignum Aquilariae Resinatum 6 parts, Radix Notoginseng 4 parts and Rhizoma Coptidis 12 parts.
The preparation method of the capsule of above-mentioned treatment gastropathy, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae) is divided into two parts according to 2:1 ratio, by 2/3rds Pseudobulbus Bletillae (Rhizoma Bletillae), the Lignum Aquilariae Resinatum of above-mentioned weight portion and Radix Notoginseng are pulverized and obtain fine powder, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are carried out percolation and obtains clear paste, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 7:3, and makes ethanol submergence medicated powder surface all the time.By 1/3rd Pseudobulbus Bletillae (Rhizoma Bletillae) water boiling and extraction, the amount adding water is 7 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of described extraction clocks from water boiling, is 1 hour, filter, by filtering residue continuation water boiling and extraction, the amount adding water is 6 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of described extraction clocks from water boiling, it is 1 hour, filter, merging filtrate, obtain thick paste by concentrated for filtrate.Again by fine powder, clear paste and thick paste mix, dry, pulverize granulate encapsulated, the capsule of the gastropathy that obtains medical treatment.
Embodiment 2
A kind of capsule for the treatment of gastropathy of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 45 parts, Bulbus Fritillariae Thunbergii 12 parts, Lignum Aquilariae Resinatum 4 parts, Radix Notoginseng 8 parts and Rhizoma Coptidis 8 parts.
The preparation method of the capsule of above-mentioned treatment gastropathy, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are merged, add ethanol and carry out percolation, the liquid-solid ratio of the ethanol added and Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis total amount is 5:5, and submergence medicated powder is surperficial all the time to make ethanol.Collect percolate, when percolate is without color, stop percolation, percolate is concentrated, dry, pulverize granulate encapsulated, the capsule of the gastropathy that namely obtains medical treatment.
Embodiment 3
A kind of capsule for the treatment of gastropathy of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 parts, Bulbus Fritillariae Thunbergii 8 parts, Lignum Aquilariae Resinatum 8 parts, Radix Notoginseng 6 parts and Rhizoma Coptidis 20 parts.
The preparation method of the capsule of above-mentioned treatment gastropathy, comprises the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion, Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are pulverized, adds water 100mL and Mel 40g, mixing, dry, pulverize and granulate encapsulated, obtain the capsule of described treatment gastropathy.
Embodiment 4
A kind of capsule for the treatment of gastropathy of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Bulbus Fritillariae Thunbergii 30 parts, Lignum Aquilariae Resinatum 1 part, Radix Notoginseng 10 parts and Rhizoma Coptidis 2 parts.
The preparation method of the capsule of above-mentioned treatment gastropathy, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae) is divided into two parts, by a Pseudobulbus Bletillae (Rhizoma Bletillae), the Lignum Aquilariae Resinatum of above-mentioned weight portion and Radix Notoginseng are pulverized and obtain fine powder, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are carried out percolation and obtains clear paste, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 8:2, and makes ethanol submergence medicated powder surface all the time.By another part of Pseudobulbus Bletillae (Rhizoma Bletillae) water boiling and extraction, the amount adding water is 7 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of described extraction clocks from water boiling, is 1 hour, filters, concentrate and obtain thick paste.Again fine powder, clear paste and thick paste are mixed, the capsule of the gastropathy that obtains medical treatment.
Embodiment 5
A kind of capsule for the treatment of gastropathy of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 60 parts, Bulbus Fritillariae Thunbergii 2 parts, Lignum Aquilariae Resinatum 10 parts, Radix Notoginseng 1 part and Rhizoma Coptidis 30 parts.
The preparation method of the capsule of above-mentioned treatment gastropathy, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are merged, add ethanol and carry out percolation, the liquid-solid ratio of the ethanol added and Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis total amount is 7:3, and submergence medicated powder is surperficial all the time to make ethanol.Collect percolate, when percolate is without color, stop percolation, percolate is concentrated, the capsule of the gastropathy that namely obtains medical treatment.
One, effect learns test
Treat effect of the capsule of gastropathy according to the present invention and cure mainly, according to the Principles and measurements of " study of tcm new drug guide ", effect of controlling in advance on chronic atrophic gastritis is carried out on it, has affected gastric emptying and function of promoting blood circulation to disperse blood clots etc. and cure mainly relevant Pharmacodynamic test of active extract research with function.
Chronic atrophic gastritis is tested: freely drink 0.02% ammonia after 60 days to rat, and rat gastric juice stomach function regulating acid secretion reduces, and pepsin activity reduces, and histopathological examination is shown as chronic inflammatory disease and changes.By 0.2,0.4,0.8g/kg, the preventative gavage of rat is treated to the capsule 30 days of gastropathy to the present invention, chronic atrophic gastritis test shows, the capsule that the present invention treats gastropathy can promote the secretion of gastric juice and gastric acid, increase pepsin activity, improve the pathological change degree of gastric tissue.
Freely drink 0.02% ammonia after 90 days to rat, rat gastric juice stomach function regulating acid secretion reduces, and pepsin activity reduces, and histopathological examination is shown as chronic inflammatory disease and changes.Drinking ammonia after 60 days, while continuing to drink ammonia, by 0.2,0.4,0.8g/kg, rat therapeutic gavage is treated to the capsule 30 days of gastropathy to the present invention, chronic atrophic gastritis test shows, the capsule that the present invention treats gastropathy can promote the secretion of gastric juice and gastric acid, increases pepsin activity, improves the pathological change degree of gastric tissue.
Emptying test: Kunming mouse 40, male and female half and half, body weight 20 ~ 25g, fasting 12h before experiment, freely drinks water.Be divided into 4 groups at random, often organize 10.This experiment is divided into experimental group and matched group, and wherein, experiment component is low dose group 0.2g/kg, middle dosage group 0.4g/kg, high dose group 0.8g/kg tri-groups.Matched group is normally fed.Experimental group successive administration 10 days, every day 1 time, fasting 16h (can't help water) after last administration, every mouse stomach gives 0.1% methyl orange solution 0.2mL, after 30min, mice is put to death in place's dislocation, opens abdomen rapidly, wins stomach and be placed in beaker, add 10ml water, cut off coat of the stomach, stomach is fully washed in water, with sodium bicarbonate solution adjust ph to 6 ~ 6.5, pour centrifuge tube into, with the centrifugal 4min of 5000r/min, incline and supernatant, under wavelength 420nm, measure the absorbance of solution with spectrophotometer, as the remaining methyl orange amount of gastric, average.Methyl orange Stomach residue rate (%)=stomach methyl orange absorbance/radix methyl orange absorbance × 100% (distilled water that 0.1% methyl orange 0.2mL adds 10mL shakes up its absorbance of rear measurement as radix methyl orange absorbance).Experimental result is in table 1:
Table 1
The result of table 1 shows: the capsule for the treatment of gastropathy of the present invention obviously reduces methyl orange residual rate in experimental mice stomach, illustrates that the capsule for the treatment of gastropathy of the present invention effectively promotes gastric emptying.
Blood circulation promoting and blood stasis dispelling is tested: by 0.2,0.4,0.8g/kg, rat therapeutic gavage is treated to the capsule 30 days of gastropathy to the present invention, blood circulation promoting and blood stasis dispelling test shows, the capsule that the present invention treats gastropathy can make rat mesentery capillary vessel number increase, bore increases, blood flow rate is accelerated, and prompting can improve Rat Mesenteric Microcirculation, has function of promoting blood circulation to disperse blood clots.
Result of the test illustrates, the capsule that the present invention treats gastropathy has preventive and therapeutic effect to the Chronic Atrophic Gastritis in Rat that ammonia brings out, and also has simultaneously and promotes gastric emptying and function of promoting blood circulation to disperse blood clots.
Two, anxious poison test, long term toxication
Anxious poison test: the present invention does not find obvious acute toxicity after treating the capsule mouse stomach administration of gastropathy, and mice maximum dosage-feeding on the one is 50g/kg.
Long term toxication: according to new Chinese medicine toxicologic study technical requirement, have studied six months (clinical course for the treatment of 3 ~ 6 times) long term toxicities that the present invention treats the Capsule in Rats of gastropathy.Result shows, the capsule for the treatment of gastropathy with the present invention according to 3,10,15g/kg, to the continuous gavage of rat six months, except rat body weight being increased and has certain facilitation, the general status of rat, hematology, blood biochemical analysis, routine urinalysis, electrocardiogram, Systematic anatomy, organ coefficient and histopathology are all had no significant effect, do not find toxic reaction, convalescent period is also without retardance toxic reaction.
Observe through anxious poison, long term toxication, have no side effect.
Three, clinical trial
30 examples are diagnosed as the sufferer of chronic atrophic gastritis from hospital outpatient and in-patient department.Wherein male 15 example, women 15 example.Age was at 18 ~ 60 years old.Chronic atrophic gastritis is divided into the pattern of syndrome such as incoordination between the liver and stomach, Deficiency and coldness of spleen and stomach, weakness of the spleen and stomach clinically, main manifestations is epigastrium dull pain, loss of appetite, after meal glutted and become thin, the disease such as tired.Take symptom integral value to the symptom of sufferer and parameters for observation on effect, symptom integral value takes level Four point system, point light, in, heavy, serious, remember 1,2,3,4 point respectively.30 routine sufferers are observation case, do not establish contrast groups, and the oral the present invention of viewing duration treats the capsule of gastropathy, each 0.35g, every day 2 times.Take 30 days continuously, strict other variable factors of control.Statistical result.
Curative effect judging standard and experimental result
Cure: symptom integral value declines more than 91%; Effective: symptom integral value declines 71% ~ 90%; Effective: symptom integral value declines 35% ~ 70%; Invalid: symptom integral value declines less than 35%.Total effective rate is (curing number of cases+effective number of cases+effectively number of cases)/total number of cases.
Experimental result is in table 2:
Table 2
As can be known from the results of Table 2, the sufferer being diagnosed as chronic atrophic gastritis treats the capsule of gastropathy after 30 days taking the present invention continuously, and total effective rate reaches 93.3%.The capsule that the present invention treats gastropathy has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach and to burst intestinal, gastritis effect, is used for the treatment of chronic gastritis and has the features such as curative effect is fast, cure rate is high and have no side effect.
Medication viewing duration, sufferer blood, urine, stool routine and liver function no abnormality seen change, and find no any toxic and side effects and untoward reaction.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. treat a capsule for gastropathy, it is characterized in that, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
2. the capsule for the treatment of gastropathy according to claim 1, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 45 parts, Bulbus Fritillariae Thunbergii 2 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts and Rhizoma Coptidis 2 ~ 20 parts.
3. the capsule for the treatment of gastropathy according to claim 2, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 ~ 45 parts, Bulbus Fritillariae Thunbergii 8 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 8 parts, Radix Notoginseng 4 ~ 8 parts and Rhizoma Coptidis 8 ~ 20 parts.
4. treat a preparation method for the capsule of gastropathy, it is characterized in that, comprise the steps:
The Rhizoma Coptidis of the Pseudobulbus Bletillae (Rhizoma Bletillae) of 10 ~ 60 parts, the Bulbus Fritillariae Thunbergii of 2 ~ 30 parts, the Lignum Aquilariae Resinatum of 1 ~ 10 part, the Radix Notoginseng of 1 ~ 10 part and 2 ~ 30 parts is pulverized and/or with solvent extraction, makes capsule.
5. the preparation method of the capsule for the treatment of gastropathy according to claim 4, is characterized in that, comprise the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned mass parts is pulverized/use solvent extraction, obtain Rhizoma Bletillae powder and/or Pseudobulbus Bletillae (Rhizoma Bletillae) cream;
The Lignum Aquilariae Resinatum of above-mentioned mass parts is pulverized, obtains Lignum Aquilariae Resinatum powder;
The Radix Notoginseng of above-mentioned mass parts is pulverized, obtains Radix Notoginseng powder;
By the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction, obtain clear paste; And
By described Rhizoma Bletillae powder and/or the mixing of Pseudobulbus Bletillae (Rhizoma Bletillae) cream, Lignum Aquilariae Resinatum powder, Radix Notoginseng powder and clear paste, make capsule.
6. the preparation method of the capsule for the treatment of gastropathy according to claim 5, it is characterized in that, comprise the steps: the Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion to be divided into first part and second part totally two parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of first part is pulverized and obtains Rhizoma Bletillae powder, by the Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction of second part, concentrate and obtain Pseudobulbus Bletillae (Rhizoma Bletillae) cream, by the Bulbus Fritillariae Thunbergii of described Rhizoma Bletillae powder, described Pseudobulbus Bletillae (Rhizoma Bletillae) cream and above-mentioned weight portion, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis mixing, make capsule.
7. the preparation method of the capsule for the treatment of gastropathy according to claim 6, is characterized in that, the Pseudobulbus Bletillae (Rhizoma Bletillae) of described first part and the Pseudobulbus Bletillae (Rhizoma Bletillae) weight ratio of described second part are 1 ~ 2:1.
8. the preparation method of the capsule for the treatment of gastropathy according to claim 4, is characterized in that, described solvent is at least one of water and ethanol.
9. the preparation method of the capsule for the treatment of gastropathy according to claim 4, is characterized in that, comprise the steps:
By the Rhizoma Coptidis solvent extraction of the Pseudobulbus Bletillae (Rhizoma Bletillae) of 10 ~ 60 parts, the Bulbus Fritillariae Thunbergii of 2 ~ 30 parts, the Lignum Aquilariae Resinatum of 1 ~ 10 part, the Radix Notoginseng of 1 ~ 10 part and 2 ~ 30 parts, obtain concentrate, obtain the capsule of described treatment gastropathy.
10. the preparation method of the capsule for the treatment of gastropathy according to claim 4, it is characterized in that, describedly the Rhizoma Coptidis of the Pseudobulbus Bletillae (Rhizoma Bletillae) of 10 ~ 60 parts, the Bulbus Fritillariae Thunbergii of 2 ~ 30 parts, the Lignum Aquilariae Resinatum of 1 ~ 10 part, the Radix Notoginseng of 1 ~ 10 part and 2 ~ 30 parts to be pulverized and/or with after solvent extraction, comprise step: dry, pulverize granulation encapsulated, obtain the capsule of described treatment gastropathy.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410831232.1A CN104524215B (en) | 2014-12-26 | 2014-12-26 | Treat capsule of stomach trouble and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410831232.1A CN104524215B (en) | 2014-12-26 | 2014-12-26 | Treat capsule of stomach trouble and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104524215A true CN104524215A (en) | 2015-04-22 |
| CN104524215B CN104524215B (en) | 2018-02-13 |
Family
ID=52839971
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410831232.1A Active CN104524215B (en) | 2014-12-26 | 2014-12-26 | Treat capsule of stomach trouble and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN104524215B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232991A (en) * | 2015-11-13 | 2016-01-13 | 李毅 | Medicine composition for treating gastric mucosal lesion |
| CN105902814A (en) * | 2016-05-24 | 2016-08-31 | 扬州大学临床中医学院 | Three-powder ulcer healing powder and preparation method thereof |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54135210A (en) * | 1978-04-07 | 1979-10-20 | Shigeru Yuuchi | Tumor treating agent |
| JPH037235A (en) * | 1989-03-24 | 1991-01-14 | Nitto Denko Corp | Medicine for stomach and bowel |
| CN1291505A (en) * | 1999-08-31 | 2001-04-18 | 周智勇 | Medicine for treating gastroenteropathy and its preparing process |
-
2014
- 2014-12-26 CN CN201410831232.1A patent/CN104524215B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54135210A (en) * | 1978-04-07 | 1979-10-20 | Shigeru Yuuchi | Tumor treating agent |
| JPH037235A (en) * | 1989-03-24 | 1991-01-14 | Nitto Denko Corp | Medicine for stomach and bowel |
| CN1291505A (en) * | 1999-08-31 | 2001-04-18 | 周智勇 | Medicine for treating gastroenteropathy and its preparing process |
Non-Patent Citations (3)
| Title |
|---|
| 中华人民共和国卫生部药典委员会: "《中华人民共和国卫生部 药品标准 中药成方制剂第十五册》", 31 December 1998 * |
| 邓修: "《中药制药工程与技术》", 31 May 2008, 上海：华东理工大学出版社 * |
| 韦超等: "《药剂学 第2版》", 31 August 2012, 郑州：河南科学技术出版社 * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105232991A (en) * | 2015-11-13 | 2016-01-13 | 李毅 | Medicine composition for treating gastric mucosal lesion |
| CN105232991B (en) * | 2015-11-13 | 2018-03-20 | 李毅 | A kind of pharmaceutical composition for treating mucosal lesion |
| CN105902814A (en) * | 2016-05-24 | 2016-08-31 | 扬州大学临床中医学院 | Three-powder ulcer healing powder and preparation method thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN104524215B (en) | 2018-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103099959B (en) | Traditional Chinese medicine preparation for treating ulcerative colitis and preparation method thereof | |
| CN104606513A (en) | Traditional Chinese medicine for treating cardiovascular and cerebrovascular diseases and preparation method of traditional Chinese medicine | |
| CN104288644A (en) | Pharmaceutical composition for treating spleen deficiency and preparation method thereof | |
| CN103893738B (en) | A kind of suppression tumor growth Chinese medicine composition and preparation method thereof | |
| CN101757591B (en) | Traditional Chinese medicine composition for treating chronic colitis and protitis | |
| CN104524214A (en) | Traditional Chinese medicine composition for treating digestive ulcer as well as traditional Chinese medicine preparation, preparation method and application thereof | |
| CN108992600A (en) | A kind of Chinese medicine composition and its application for weight-reducing | |
| CN105213974A (en) | One treats lymphadenomatous Chinese medicine composition and application thereof | |
| CN104524215A (en) | Capsules for treating stomach diseases and preparation method thereof | |
| CN102552796B (en) | Chinese medicinal composition for treating chronic gastric ulcer | |
| CN102742828B (en) | Dietetic therapy product for protecting prostate and preparation method thereof | |
| CN103479947A (en) | Preparation method of medicine for preventing and treating constipation | |
| CN103040975B (en) | Traditional Chinese medicine composition for nursing and treating infantile diarrhea | |
| CN105477465A (en) | Chinese herb preparation with liver protection function and preparing technology of Chinese herb preparation | |
| CN105126008A (en) | Traditional Chinese medicine combination for treating infantile diarrhea and preparation method thereof | |
| CN105193998A (en) | Traditional Chinese medicine for treatment of iron deficiency anemia | |
| CN104587310A (en) | Particle for promoting digestion and regulating qi and preparation method of particle | |
| CN115414427B (en) | Traditional Chinese medicine composition for treating chronic skin pruritus and preparation method and application thereof | |
| CN102302655A (en) | Loquat acne removing capsules | |
| CN102755419A (en) | Chinese and Western medicine compound preparation for treating chronic gastritis and peptic ulcer | |
| CN103405745A (en) | Traditional Chinese medicine composition for treating canine gastroenteritis | |
| CN108186799A (en) | Ground bone slender acanthopanax dissipates and preparation method | |
| CN106389680A (en) | Solid dispersion for treating peptic ulcer | |
| CN105770766A (en) | Traditional Chinese medicine preparation for treating upper gastrointestinal hemorrhage | |
| CN104622983A (en) | Traditional Chinese medicine composition for treating proctitis and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |