CN104524214A - Traditional Chinese medicine composition for treating digestive ulcer as well as traditional Chinese medicine preparation, preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for treating digestive ulcer as well as traditional Chinese medicine preparation, preparation method and application thereof Download PDFInfo
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Abstract
The invention discloses a traditional Chinese medicine composition for treating digestive ulcer as well as a traditional Chinese medicine preparation, a preparation method and application thereof. The traditional Chinese medicine composition for treating the digestive ulcer is prepared from the following medicinal raw materials in parts by weight: 10-60 parts of common bletilla pseudobulb, 2-30 parts of bulb of thunberg fritillary, 1-10 parts of Chinese eaglewood, 1-10 parts of pseudo-ginseng and 2-30 parts of rhizoma coptidis. The traditional Chinese medicine composition for treating the digestive ulcer has the efficacies of promoting blood circulation, arresting pain, astringing to stop bleeding and resisting gastric ulcer and gastritis, is used for treating chronic gastritis, stomach-heat, phlegmatic mass, stagnancy of qi and blood stasis, gastric cavity distending pain, gastric ulcer and duodenal ulcer and has the characteristics of fast curative effect, high cure rate, no side effect and the like.
Description
Technical field
The present invention relates to the field of Chinese medicines, particularly relate to a kind of Chinese medicine composition and Chinese medicine preparation, the preparation method and application that treat digestive tract ulcer.
Background technology
Digestive tract ulcer comprises chronic gastritis, gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach burst intestinal and duodenal ulcer etc., wherein chronic gastritis is divided into chronic superficial gastritis and chronic atrophic gastritis, chronic superficial gastritis develops into severe stage, is chronic atrophic gastritis.Chronic atrophic gastritis is digestive system commonly encountered diseases, the frequently-occurring disease of comparatively obstinate refractory, is easily converted into gastric cancer.The cause of disease of current chronic gastritis is not yet illustrated, and therefore modern medicine only takes local symptomatic treatment or operative treatment targetedly.Therefore the pharmaceutical composition of exploitation treatment digestive tract ulcer has very important significance.
Summary of the invention
Based on this, be necessary to provide a kind of Chinese medicine composition and Chinese medicine preparation, the preparation method and application that treat digestive tract ulcer.
Treat a Chinese medicine composition for digestive tract ulcer, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
Wherein in an embodiment, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 45 parts, Bulbus Fritillariae Thunbergii 2 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts and Rhizoma Coptidis 2 ~ 20 parts.
Wherein in an embodiment, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 ~ 45 parts, Bulbus Fritillariae Thunbergii 8 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 8 parts, Radix Notoginseng 4 ~ 8 parts and Rhizoma Coptidis 8 ~ 20 parts.
Wherein in an embodiment, count by weight, the raw material primarily of following weight parts is prepared from: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
Treat a preparation method for the Chinese medicine composition of digestive tract ulcer, comprise the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion, Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are pulverized and/or with solvent extraction, obtains the Chinese medicine composition of described treatment digestive tract ulcer.
Wherein in an embodiment, comprise the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned mass parts, Lignum Aquilariae Resinatum and Radix Notoginseng are pulverized, obtains fine powder;
By the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction, obtain clear paste; And
By described fine powder and the mixing of described clear paste, obtain the Chinese medicine composition of described treatment digestive tract ulcer.
Wherein in an embodiment, the Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion is divided into first part and second part totally two parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of first part is pulverized and obtains Rhizoma Bletillae powder, by the Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction of second part, concentrate and obtain Pseudobulbus Bletillae (Rhizoma Bletillae) cream, by the Bulbus Fritillariae Thunbergii of described Rhizoma Bletillae powder, described Pseudobulbus Bletillae (Rhizoma Bletillae) cream and above-mentioned weight portion, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis mixing, obtain the Chinese medicine composition of described treatment digestive tract ulcer.
The application that Chinese medicine composition treats digestive tract ulcer in preparation, stomach is burst in the medicine of intestinal and duodenal ulcer of above-mentioned treatment digestive tract ulcer.
Treat a Chinese medicine preparation for digestive tract ulcer, to comprise on the Chinese medicine composition of above-mentioned treatment digestive tract ulcer and medicine or acceptable adjuvant on health food.
Wherein in an embodiment, the dosage form of the Chinese medicine preparation of described treatment digestive tract ulcer is: oral liquid, tablet, capsule, pill, granule, powder, drop pill, decoction or unguentum.
The Chinese medicine composition that the present invention treats digestive tract ulcer is based on theory of Chinese medical science, and in conjunction with clinical practice, what filter out from Chinese medicine material treasure-house a series ofly has promoting blood circulation and stopping pain, the Chinese crude drug of astringing to arrest bleeding effect.Wherein, Pseudobulbus Bletillae (Rhizoma Bletillae), property is bitter, sweet to be slightly cold, and has astringing to arrest bleeding, effect of detumescence and promoting granulation, spits blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin, pulmonary tuberculosis hemoptysis, the diseases such as ulcer haemorrhage and the external such as skin infection, burn and scald; Bulbus Fritillariae Thunbergii hardship is sweet, is slightly cold, and has effect of hemostasisization disease, for cough due to lung-heat, and heat clearing away eliminating stagnation, the disease such as scrofula and carbuncle; Lignum Aquilariae Resinatum, there is strong antibacterial efficacy and clear god regulates the flow of vital energy, tonifying five ZANG-organs, relieving cough and resolving phlegm, warming the stomach warming the spleen, ventilation analgesic therapy effect; Radix Notoginseng, the sweet mildly bitter flavor of property, warm in nature, can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function; Rhizoma Coptidis, sweet in the mouth cold nature, has effect of relieving heat toxin, and irritated for calentura, mouth tells raw skin ulcer, spits blood, epistaxis, the diseases such as conjunctival congestion and swelling pain, dysentery hemorrhoid, gastropyretic vomiting.The present invention treats the drug component of the Chinese medicine composition of digestive tract ulcer through dialectical compatibility, complement each other using, there is synergism, play promoting blood circulation and stopping pain altogether, the effects such as astringing to arrest bleeding, there is significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach to burst intestinal, gastritis effect, for chronic gastritis, treatment gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach is burst intestinal and duodenal ulcer, has the features such as curative effect is fast, cure rate is high and have no side effect.
Detailed description of the invention
For the ease of understanding the present invention, below the present invention is described more fully, and gives preferred embodiment of the present invention.But the present invention can realize in many different forms, is not limited to embodiment described herein.On the contrary, provide the object of these embodiments be make the understanding of disclosure of the present invention more comprehensively thorough.
Unless otherwise defined, all technology used herein and scientific terminology are identical with belonging to the implication that those skilled in the art of the present invention understand usually.The object of term used in the description of the invention herein just in order to describe specific embodiment, is not intended to be restriction the present invention.Term as used herein " and/or " comprise arbitrary and all combinations of one or more relevant Listed Items.
The Chinese medicine composition of the treatment digestive tract ulcer of one embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
Especially, Rhizoma Coptidis is Fructus Evodiae Rhizoma Coptidis (processed).Rhizoma Coptidis bitter cold injures one's stomach, and Fructus Evodiae is hot in nature, so can alleviate the cold of Rhizoma Coptidis after Fructus Evodiae Rhizoma Coptidis (parched), Rhizoma Coptidis like this is not cold then can not imapirment of the spleen and stomach.
Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis in the preparation, are pulverized by the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, cross 100 mesh sieves.
Preferably, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 45 parts, Bulbus Fritillariae Thunbergii 2 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts and Rhizoma Coptidis 2 ~ 20 parts.
Preferred, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 ~ 45 parts, Bulbus Fritillariae Thunbergii 8 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 8 parts, Radix Notoginseng 4 ~ 8 parts and Rhizoma Coptidis 8 ~ 20 parts.
The Chinese medicine composition that the present invention treats digestive tract ulcer is based on theory of Chinese medical science, and in conjunction with clinical practice, what filter out from Chinese medicine material treasure-house a series ofly has promoting blood circulation and stopping pain, the Chinese crude drug of astringing to arrest bleeding effect.
Wherein, Pseudobulbus Bletillae (Rhizoma Bletillae), property is bitter, sweet to be slightly cold, and has astringing to arrest bleeding, effect of detumescence and promoting granulation, spits blood for hemoptysis, traumatic hemorrhage, sore swollen toxin, chapped skin, pulmonary tuberculosis hemoptysis, the diseases such as ulcer haemorrhage and the external such as skin infection, burn and scald.
Bulbus Fritillariae Thunbergii hardship is sweet, is slightly cold, and has effect of hemostasisization disease, for cough due to lung-heat, and heat clearing away eliminating stagnation, the disease such as scrofula and carbuncle.
Lignum Aquilariae Resinatum, there is strong antibacterial efficacy and clear god regulates the flow of vital energy, tonifying five ZANG-organs, relieving cough and resolving phlegm, warming the stomach warming the spleen, ventilation analgesic therapy effect.
Radix Notoginseng, the sweet mildly bitter flavor of property, warm in nature, can hemostasia and dissipation blood stasis, reducing swelling and alleviating pain, there is good hemostasia effect, significant hemopoietic function.
Rhizoma Coptidis, sweet in the mouth cold nature, has effect of relieving heat toxin, and irritated for calentura, mouth tells raw skin ulcer, spits blood, epistaxis, the diseases such as conjunctival congestion and swelling pain, dysentery hemorrhoid, gastropyretic vomiting.
The present invention treats the drug component of the Chinese medicine composition of digestive tract ulcer through dialectical compatibility, complement each other using, there is synergism, play promoting blood circulation and stopping pain altogether, the effects such as astringing to arrest bleeding, there is significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach to burst intestinal, gastritis effect, for chronic gastritis, treatment gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach is burst intestinal and duodenal ulcer, has the features such as curative effect is fast, cure rate is high and have no side effect.
Be appreciated that the preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, can be blended pulverizing.During use, by the blended pulverizing of Chinese medicine composition of above-mentioned treatment digestive tract ulcer, with soak by water.
The Chinese medicine composition of the treatment digestive tract ulcer of another embodiment, counts by weight, and the raw material primarily of following weight parts is prepared from: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, comprises the steps:
S1: the Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion is divided into two parts, pulverizes a copy of it Pseudobulbus Bletillae (Rhizoma Bletillae) and obtains Rhizoma Bletillae powder, by another part of Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction, concentrates and obtains Pseudobulbus Bletillae (Rhizoma Bletillae) cream.
Especially, Rhizoma Bletillae powder is crossed 100 mesh sieves.Especially, the Pseudobulbus Bletillae (Rhizoma Bletillae) being used for pulverizing is 1 ~ 2:1 with the weight ratio of the Pseudobulbus Bletillae (Rhizoma Bletillae) for extracting, and is preferably 1:1.
Especially, solvent is selected from least one in water and ethanol.Be water boiling and extraction method, alcohol dipping extraction method or ethanol percolate extraction method by the method for Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction.
Preferably, be water boiling and extraction method by the method for Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction, and take twice step by step arithmetic.First time extracts, and obtains the first filtrate and the first filtering residue, the first filtering residue is carried out second time and extracts, filter and obtain the second filtrate and the second filtering residue, merge the first filtrate and the second filtrate.
First time extracts: the amount adding water is 4 ~ 10 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, is 0.5 ~ 2 hour.Preferably, the amount adding water is 7 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, is 1 hour.
Second time is extracted: the amount adding water is 4 ~ 10 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, is 0.5 ~ 2 hour.Preferably, the amount adding water is 6 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, is 1 hour.
S2: the Lignum Aquilariae Resinatum of above-mentioned mass parts is pulverized, obtains Lignum Aquilariae Resinatum powder.
Especially, Lignum Aquilariae Resinatum was crushed to 100 mesh sieves.
S3: the Radix Notoginseng of above-mentioned mass parts is pulverized, obtains Radix Notoginseng powder.
Especially, Radix Notoginseng powder was broken to 100 mesh sieves.
S4: by the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction, obtain clear paste.
Especially, solvent is selected from least one in water and ethanol.The method extracted is water boiling and extraction method, alcohol dipping extraction method or ethanol percolate extraction method.
Preferably, be ethanol percolate extraction method by the method for the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction.Especially, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are added ethanol and carries out percolation, collect percolate, when percolate is without color, stop percolation, percolate is concentrated, namely obtains clear paste.Especially, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are added ethanol and carry out percolation step and also obtain filtering residue, filtering residue is squeezed, obtains pressed liquor, pressed liquor and percolate are merged, concentrates.Be appreciated that and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis can be extracted separately.
Especially, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 5 ~ 8:2 ~ 5, and makes ethanol submergence medicated powder surface all the time.Preferred, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 7:3.
S5: Rhizoma Bletillae powder, Lignum Aquilariae Resinatum powder, Radix Notoginseng powder and clear paste are mixed, the Chinese medicine composition of the digestive tract ulcer that obtains medical treatment.
Be appreciated that step S1 can omit, Pseudobulbus Bletillae (Rhizoma Bletillae) all carried out pulverize or all use solvent extraction, obtain extracting solution or concentrate, carry out step S5.Step S2 can omit, and by Lignum Aquilariae Resinatum solvent extraction, obtains extracting solution or concentrate, carries out step S5.Step S3 can omit, and by Radix Notoginseng solvent extraction, obtains extracting solution or concentrate, carries out step S5.By step S4 solvent extraction, extracting solution can be obtained, directly carry out step S5.Step S4 can omit, and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis is pulverized, carries out step S5.
Be appreciated that and can not adopt above-mentioned preparation method, Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are pulverized, the Chinese medicine composition of the digestive tract ulcer that obtains medical treatment; Or Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are extracted, the Chinese medicine composition of the digestive tract ulcer that obtains medical treatment.The Chinese medicine composition of above-mentioned treatment digestive tract ulcer adopts the conventional method of oral liquid, tablet, capsule, pill, granule, powder, drop pill, decoction or unguentum Chinese medicine preparation to obtain.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, method is simple to operation, take full advantage of the effective ingredient of raw material, maximally utilised raw material, the Chinese medicine composition prepared has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach and to burst intestinal, gastritis effect, for chronic gastritis, treatment gastric heat fullness and oppression sensation in the epigastrium due to accumulation of phlegm, stagnation of QI and blood, epigastric distending pain, stomach is burst intestinal and duodenal ulcer, has the features such as curative effect is fast, cure rate is high and have no side effect.
The application that Chinese medicine composition treats digestive tract ulcer in preparation, stomach is burst in the medicine of intestinal and duodenal ulcer of above-mentioned treatment digestive tract ulcer.
Treat a Chinese medicine preparation for digestive tract ulcer, to comprise on the Chinese medicine composition of above-mentioned treatment digestive tract ulcer and medicine or acceptable adjuvant on health food.Preferably, the dosage form for the treatment of the Chinese medicine preparation of digestive tract ulcer is: oral liquid, tablet, capsule, pill, granule, powder, drop pill, decoction or unguentum.
It is below specific embodiment.
Embodiment 1
A kind of Chinese medicine composition for the treatment of digestive tract ulcer of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 35 parts, Bulbus Fritillariae Thunbergii 20 parts, Lignum Aquilariae Resinatum 6 parts, Radix Notoginseng 4 parts and Rhizoma Coptidis 12 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae) is divided into two parts according to 2:1 ratio, by 2/3rds Pseudobulbus Bletillae (Rhizoma Bletillae), the Lignum Aquilariae Resinatum of above-mentioned weight portion and Radix Notoginseng are pulverized and obtain fine powder, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are carried out percolation and obtains clear paste, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 7:3, and makes ethanol submergence medicated powder surface all the time.By 1/3rd Pseudobulbus Bletillae (Rhizoma Bletillae) water boiling and extraction, the amount adding water is 7 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, is 1 hour, filter, by filtering residue continuation water boiling and extraction, the amount adding water is 6 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, it is 1 hour, filter, merging filtrate, obtain thick paste by concentrated for filtrate.Again fine powder, clear paste and thick paste are mixed, the Chinese medicine composition of the digestive tract ulcer that obtains medical treatment.
Embodiment 2
A kind of Chinese medicine composition for the treatment of digestive tract ulcer of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 45 parts, Bulbus Fritillariae Thunbergii 12 parts, Lignum Aquilariae Resinatum 4 parts, Radix Notoginseng 8 parts and Rhizoma Coptidis 8 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are merged, add ethanol and carry out percolation, the liquid-solid ratio of the ethanol added and Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis total amount is 5:5, and submergence medicated powder is surperficial all the time to make ethanol.Collect percolate, when percolate is without color, stop percolation, percolate is concentrated, the Chinese medicine composition of the digestive tract ulcer that namely obtains medical treatment.
Embodiment 3
A kind of Chinese medicine composition for the treatment of digestive tract ulcer of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 parts, Bulbus Fritillariae Thunbergii 8 parts, Lignum Aquilariae Resinatum 8 parts, Radix Notoginseng 6 parts and Rhizoma Coptidis 20 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, comprises the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion, Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are pulverized, mixing, adds water 100mL and Mel 40g, soft material processed, pill, dry, selects ball, capping, the Chinese medicine composition of the digestive tract ulcer that obtains medical treatment.
Embodiment 4
A kind of Chinese medicine composition for the treatment of digestive tract ulcer of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 parts, Bulbus Fritillariae Thunbergii 30 parts, Lignum Aquilariae Resinatum 1 part, Radix Notoginseng 10 parts and Rhizoma Coptidis 2 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae) is divided into two parts, by a Pseudobulbus Bletillae (Rhizoma Bletillae), the Lignum Aquilariae Resinatum of above-mentioned weight portion and Radix Notoginseng are pulverized and obtain fine powder, Bulbus Fritillariae Thunbergii and Rhizoma Coptidis are carried out percolation and obtains clear paste, the liquid-solid ratio of the ethanol added and Bulbus Fritillariae Thunbergii and Rhizoma Coptidis total amount is 8:2, and makes ethanol submergence medicated powder surface all the time.By another part of Pseudobulbus Bletillae (Rhizoma Bletillae) water boiling and extraction, the amount adding water is 7 times of Pseudobulbus Bletillae (Rhizoma Bletillae) quality, and the time of extraction clocks from water boiling, is 1 hour, filters, concentrate and obtain thick paste.Again fine powder, clear paste and thick paste are mixed, the Chinese medicine composition of the digestive tract ulcer that obtains medical treatment.
Embodiment 5
A kind of Chinese medicine composition for the treatment of digestive tract ulcer of the present embodiment, counts by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 60 parts, Bulbus Fritillariae Thunbergii 2 parts, Lignum Aquilariae Resinatum 10 parts, Radix Notoginseng 1 part and Rhizoma Coptidis 30 parts.
The preparation method of the Chinese medicine composition of above-mentioned treatment digestive tract ulcer, comprises the steps:
Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are merged, add ethanol and carry out percolation, the liquid-solid ratio of the ethanol added and Pseudobulbus Bletillae (Rhizoma Bletillae), Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis total amount is 7:3, and submergence medicated powder is surperficial all the time to make ethanol.Collect percolate, when percolate is without color, stop percolation, percolate is concentrated, the Chinese medicine composition of the digestive tract ulcer that namely obtains medical treatment.
One, effect learns test
According to effect of Chinese medicine composition of the present invention with cure mainly, according to the Principles and measurements of " study of tcm new drug guide ", effect of controlling in advance on chronic atrophic gastritis is carried out on it, has affected gastric emptying and function of promoting blood circulation to disperse blood clots etc. and cure mainly relevant Pharmacodynamic test of active extract research with function.
Chronic atrophic gastritis is tested: freely drink 0.02% ammonia after 60 days to rat, and rat gastric juice stomach function regulating acid secretion reduces, and pepsin activity reduces, and histopathological examination is shown as chronic inflammatory disease and changes.By 0.2,0.4,0.8g/kg, to the preventative gavage of rat to Chinese medicine composition of the present invention 30 days, chronic atrophic gastritis test shows, Chinese medicine composition of the present invention can promote the secretion of gastric juice and gastric acid, increase pepsin activity, improve the pathological change degree of gastric tissue.
Freely drink 0.02% ammonia after 90 days to rat, rat gastric juice stomach function regulating acid secretion reduces, and pepsin activity reduces, and histopathological examination is shown as chronic inflammatory disease and changes.Drinking ammonia after 60 days, while continuing to drink ammonia, by 0.2,0.4,0.8g/kg, to rat therapeutic gavage to Chinese medicine composition of the present invention 30 days, chronic atrophic gastritis test shows, Chinese medicine composition of the present invention can promote the secretion of gastric juice and gastric acid, increases pepsin activity, improves the pathological change degree of gastric tissue.
Emptying test: Kunming mouse 40, male and female half and half, body weight 20 ~ 25g, fasting 12h before experiment, freely drinks water.Be divided into 4 groups at random, often organize 10.This experiment is divided into experimental group and matched group, and wherein, experiment component is low dose group 0.2g/kg, middle dosage group 0.4g/kg, high dose group 0.8g/kg tri-groups.Matched group is normally fed.Experimental group successive administration 10 days, every day 1 time, fasting 16h (can't help water) after last administration, every mouse stomach gives 0.1% methyl orange solution 0.2mL, after 30min, mice is put to death in place's dislocation, opens abdomen rapidly, wins stomach and be placed in beaker, add 10ml water, cut off coat of the stomach, stomach is fully washed in water, with sodium bicarbonate solution adjust ph to 6 ~ 6.5, pour centrifuge tube into, with the centrifugal 4min of 5000r/min, incline and supernatant, under wavelength 420nm, measure the absorbance of solution with spectrophotometer, as the remaining methyl orange amount of gastric, average.Methyl orange Stomach residue rate (%)=stomach methyl orange absorbance/radix methyl orange absorbance × 100% (distilled water that 0.1% methyl orange 0.2mL adds 10mL shakes up its absorbance of rear measurement as radix methyl orange absorbance).Experimental result is in table 1:
Table 1
The result of table 1 shows: Chinese medicine composition of the present invention obviously reduces methyl orange residual rate in experimental mice stomach, illustrates that Chinese medicine composition of the present invention effectively promotes gastric emptying.
Blood circulation promoting and blood stasis dispelling is tested: by 0.2,0.4,0.8g/kg, to rat therapeutic gavage to Chinese medicine composition of the present invention 30 days, blood circulation promoting and blood stasis dispelling test shows, Chinese medicine composition of the present invention can make rat mesentery capillary vessel number increase, bore increases, blood flow rate is accelerated, and prompting can improve Rat Mesenteric Microcirculation, has function of promoting blood circulation to disperse blood clots.
Result of the test illustrates, Chinese medicine composition of the present invention has preventive and therapeutic effect to the Chronic Atrophic Gastritis in Rat that ammonia brings out, and also has simultaneously and promotes gastric emptying and function of promoting blood circulation to disperse blood clots.
Two, anxious poison test, long term toxication
Anxious poison test: after Chinese medicine composition mouse stomach of the present invention administration, do not find obvious acute toxicity, mice maximum dosage-feeding on the one is 50g/kg.
Long term toxication: according to new Chinese medicine toxicologic study technical requirement, have studied Chinese medicine composition of the present invention six months (clinical course for the treatment of 3 ~ 6 times) long term toxicities to rat.Result shows, with Chinese medicine composition of the present invention according to 3,10,15g/kg, to the continuous gavage of rat six months, except rat body weight being increased and has certain facilitation, the general status of rat, hematology, blood biochemical analysis, routine urinalysis, electrocardiogram, Systematic anatomy, organ coefficient and histopathology are all had no significant effect, do not find toxic reaction, convalescent period is also without retardance toxic reaction.
Observe through anxious poison, long term toxication, have no side effect.
Three, clinical trial
30 examples are diagnosed as the sufferer of chronic atrophic gastritis from hospital outpatient and in-patient department.Wherein male 15 example, women 15 example.Age was at 18 ~ 60 years old.Chronic atrophic gastritis is divided into the pattern of syndrome such as incoordination between the liver and stomach, Deficiency and coldness of spleen and stomach, weakness of the spleen and stomach clinically, main manifestations is epigastrium dull pain, loss of appetite, after meal glutted and become thin, the disease such as tired.Take symptom integral value to the symptom of sufferer and parameters for observation on effect, symptom integral value takes level Four point system, point light, in, heavy, serious, remember 1,2,3,4 point respectively.30 routine sufferers are observation case, do not establish contrast groups, the oral Chinese medicine composition of the present invention of viewing duration, each 0.35g, every day 2 times.Take 30 days continuously, strict other variable factors of control.Statistical result.
Curative effect judging standard and experimental result
Cure: symptom integral value declines more than 91%; Effective: symptom integral value declines 71% ~ 90%; Effective: symptom integral value declines 35% ~ 70%; Invalid: symptom integral value declines less than 35%.Total effective rate is (curing number of cases+effective number of cases+effectively number of cases)/total number of cases.
Experimental result is in table 2:
Table 2
As can be known from the results of Table 2, the sufferer being diagnosed as chronic atrophic gastritis is taking Chinese medicine composition of the present invention after 30 days continuously, and total effective rate reaches 93.3%.Chinese medicine composition of the present invention has significant promoting blood circulation and stopping pain, astringing to arrest bleeding and anti-stomach and to burst intestinal, gastritis effect, is used for the treatment of digestive tract ulcer and has the features such as curative effect is fast, cure rate is high and have no side effect.
Medication viewing duration, sufferer blood, urine, stool routine and liver function no abnormality seen change, and find no any toxic and side effects and untoward reaction.
The above embodiment only have expressed several embodiment of the present invention, and it describes comparatively concrete and detailed, but therefore can not be interpreted as the restriction to the scope of the claims of the present invention.It should be pointed out that for the person of ordinary skill of the art, without departing from the inventive concept of the premise, can also make some distortion and improvement, these all belong to protection scope of the present invention.Therefore, the protection domain of patent of the present invention should be as the criterion with claims.
Claims (10)
1. treat a Chinese medicine composition for digestive tract ulcer, it is characterized in that, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
2. the Chinese medicine composition for the treatment of digestive tract ulcer according to claim 1, is characterized in that, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 45 parts, Bulbus Fritillariae Thunbergii 2 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 10 parts, Radix Notoginseng 4 ~ 10 parts and Rhizoma Coptidis 2 ~ 20 parts.
3. the Chinese medicine composition for the treatment of digestive tract ulcer according to claim 2, is characterized in that, count by weight, comprising: Pseudobulbus Bletillae (Rhizoma Bletillae) 25 ~ 45 parts, Bulbus Fritillariae Thunbergii 8 ~ 20 parts, Lignum Aquilariae Resinatum 4 ~ 8 parts, Radix Notoginseng 4 ~ 8 parts and Rhizoma Coptidis 8 ~ 20 parts.
4. treat a Chinese medicine composition for digestive tract ulcer, it is characterized in that, count by weight, the raw material primarily of following weight parts is prepared from: Pseudobulbus Bletillae (Rhizoma Bletillae) 10 ~ 60 parts, Bulbus Fritillariae Thunbergii 2 ~ 30 parts, Lignum Aquilariae Resinatum 1 ~ 10 part, Radix Notoginseng 1 ~ 10 part and Rhizoma Coptidis 2 ~ 30 parts.
5. the preparation method of the Chinese medicine composition for the treatment of digestive tract ulcer as claimed in claim 4, is characterized in that, comprise the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion, Bulbus Fritillariae Thunbergii, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis are pulverized and/or with solvent extraction, obtains the Chinese medicine composition of described treatment digestive tract ulcer.
6. the preparation method of the Chinese medicine composition for the treatment of digestive tract ulcer according to claim 5, is characterized in that, comprise the steps:
The Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned mass parts, Lignum Aquilariae Resinatum and Radix Notoginseng are pulverized, obtains fine powder;
By the Bulbus Fritillariae Thunbergii of above-mentioned mass parts and Rhizoma Coptidis solvent extraction, obtain clear paste; And
By described fine powder and the mixing of described clear paste, obtain the Chinese medicine composition of described treatment digestive tract ulcer.
7. the preparation method of the Chinese medicine composition for the treatment of digestive tract ulcer according to claim 5, it is characterized in that, comprise the steps: the Pseudobulbus Bletillae (Rhizoma Bletillae) of above-mentioned weight portion to be divided into first part and second part totally two parts, the Pseudobulbus Bletillae (Rhizoma Bletillae) of first part is pulverized and obtains Rhizoma Bletillae powder, by the Pseudobulbus Bletillae (Rhizoma Bletillae) solvent extraction of second part, concentrate and obtain Pseudobulbus Bletillae (Rhizoma Bletillae) cream, by the Bulbus Fritillariae Thunbergii of described Rhizoma Bletillae powder, described Pseudobulbus Bletillae (Rhizoma Bletillae) cream and above-mentioned weight portion, Lignum Aquilariae Resinatum, Radix Notoginseng and Rhizoma Coptidis mixing, obtain the Chinese medicine composition of described treatment digestive tract ulcer.
8. the application that Chinese medicine composition treats digestive tract ulcer in preparation, stomach is burst in the medicine of intestinal and duodenal ulcer of the treatment digestive tract ulcer as described in Claims 1 to 4 any one.
9. treat a Chinese medicine preparation for digestive tract ulcer, it is characterized in that, to comprise on the Chinese medicine composition of the treatment digestive tract ulcer described in Claims 1 to 4 and medicine or acceptable adjuvant on health food.
10. the Chinese medicine preparation for the treatment of digestive tract ulcer according to claim 9, is characterized in that, the dosage form of the Chinese medicine preparation of described treatment digestive tract ulcer is: oral liquid, tablet, capsule, pill, granule, powder, drop pill, decoction or unguentum.
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| CN114748568A (en) * | 2022-05-12 | 2022-07-15 | 华裕(无锡)制药有限公司 | Esomeprazole sodium preparation for treating digestive tract ulcer and preparation method thereof |
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