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CN104507966B - 基于补体组分c5a的疫苗 - Google Patents

基于补体组分c5a的疫苗 Download PDF

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Publication number
CN104507966B
CN104507966B CN201380035942.7A CN201380035942A CN104507966B CN 104507966 B CN104507966 B CN 104507966B CN 201380035942 A CN201380035942 A CN 201380035942A CN 104507966 B CN104507966 B CN 104507966B
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China
Prior art keywords
seq
amino acid
peptide
vaccine
disease
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Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CN201380035942.7A
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English (en)
Chinese (zh)
Other versions
CN104507966A (zh
Inventor
G.斯塔夫勒
C.兰德林杰
F.马特纳
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Affiris AG
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Affiris AG
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Priority to CN201711326410.5A priority Critical patent/CN107998386A/zh
Publication of CN104507966A publication Critical patent/CN104507966A/zh
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Expired - Fee Related legal-status Critical Current
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/472—Complement proteins, e.g. anaphylatoxin, C3a, C5a
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Toxicology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pulmonology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Virology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychology (AREA)
CN201380035942.7A 2012-05-23 2013-05-23 基于补体组分c5a的疫苗 Expired - Fee Related CN104507966B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201711326410.5A CN107998386A (zh) 2012-05-23 2013-05-23 基于补体组分c5a的疫苗

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP12169088.7 2012-05-23
EP12169088.7A EP2666785A1 (fr) 2012-05-23 2012-05-23 Vaccins basés sur la protéine complément C5a
PCT/EP2013/060618 WO2013174920A1 (fr) 2012-05-23 2013-05-23 Vaccin à base du composant c5a du complément

Related Child Applications (1)

Application Number Title Priority Date Filing Date
CN201711326410.5A Division CN107998386A (zh) 2012-05-23 2013-05-23 基于补体组分c5a的疫苗

Publications (2)

Publication Number Publication Date
CN104507966A CN104507966A (zh) 2015-04-08
CN104507966B true CN104507966B (zh) 2018-06-26

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CN201711326410.5A Pending CN107998386A (zh) 2012-05-23 2013-05-23 基于补体组分c5a的疫苗
CN201380035942.7A Expired - Fee Related CN104507966B (zh) 2012-05-23 2013-05-23 基于补体组分c5a的疫苗

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CN201711326410.5A Pending CN107998386A (zh) 2012-05-23 2013-05-23 基于补体组分c5a的疫苗

Country Status (11)

Country Link
US (1) US10344062B2 (fr)
EP (2) EP2666785A1 (fr)
JP (1) JP6189424B2 (fr)
CN (2) CN107998386A (fr)
AR (1) AR092836A1 (fr)
AU (1) AU2013265239B2 (fr)
CA (1) CA2874082A1 (fr)
DK (1) DK2852614T3 (fr)
ES (1) ES2647138T3 (fr)
PL (1) PL2852614T3 (fr)
WO (1) WO2013174920A1 (fr)

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CA2954687A1 (fr) * 2014-07-10 2016-01-14 Affiris Ag Substances et procedes a utiliser pour la prevention et/ou le traitement de la maladie de huntington
AU2016348610B2 (en) 2015-11-03 2023-08-31 Ac Immune Sa Method for vaccination against a self-antigen in a human patient
WO2017142055A1 (fr) * 2016-02-17 2017-08-24 国立大学法人 東京医科歯科大学 Facteur prédictif et procédé de test pour l'apparition de maladies artérioscléreuses
CN108017716B (zh) * 2018-01-02 2021-03-19 赖沛龙 包含C5aR胞内结构域的嵌合抗原受体、慢病毒载体、表达细胞及药物

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EP2852614A1 (fr) 2015-04-01
US20150166620A1 (en) 2015-06-18
CN104507966A (zh) 2015-04-08
PL2852614T3 (pl) 2018-02-28
CN107998386A (zh) 2018-05-08
WO2013174920A1 (fr) 2013-11-28
US10344062B2 (en) 2019-07-09
AR092836A1 (es) 2015-05-06
JP6189424B2 (ja) 2017-08-30
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