CN104435260A - Red tangerine peel and loquat tablets and preparation method thereof - Google Patents
Red tangerine peel and loquat tablets and preparation method thereof Download PDFInfo
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Classifications
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/535—Perilla (beefsteak plant)
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
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- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A—HUMAN NECESSITIES
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- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to red tangerine peel and loquat tablets and a preparation method thereof, belonging to the technical field of traditional Chinese medicines. The red tangerine peel and loquat tablets comprise the following components in parts by weight: 10-20 parts of red tangerine peels, 1-10 parts of tangerine peels, 10-20 parts of loquat leaves, 1-10 parts of platycodon root, 1-10 parts of perilla fruit, 5-15 parts of liquoric root, 1-5 parts of sugar, 15-25 parts of a filling agent and 1-3 parts of an anti-sticking agent. The preparation method comprises the following steps: decoction, extraction, granulation, tabletting and the like. The red tangerine peel and loquat tablets disclosed by the invention have good effects of relieving cough and reducing sputum, and can be used for treating excessive phlegm caused by cough.
Description
Technical field
The present invention relates to a kind of Juhongpipa Tablets and preparation method thereof, be specifically related to a kind of with Exocarpium Citri Grandis, Pericarpium Citri Reticulatae, Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae Juhongpipa Tablets that is primary raw material and preparation method thereof, belong to technical field of Chinese medicines.
Background technology
Exocarpium Citri Rubrum is the dry outside rind of rutaceae Huazhou Fructus Citri tangerinae or Fructus Citri tangerinae and variety thereof, gather after time of the year when autumn changes into winter fruit maturation, lower outer peel is cut with cutter, dry or dry in the shade, can be used for treatment cough due to wind and cold, itching of the throat abundant expectoration, food stagnation get sick from drinking too much wine and the disease such as vomiting and nausea painful abdominal mass is vexed, its medical value is high, and medication history is of a specified duration; " medicineization justice " is recorded--Exocarpium Citri Rubrum, pungently can walk crosswise eliminating stagnation, " herbal classic is met former " records the special main lung cold cough excessive phlegm of Exocarpium Citri Rubrum, deficient side multiplex it, right chronic cough diarrhea due to stagnation of QI, non-institute is suitable again, and " medical center bun will " describes Exocarpium Citri Rubrum and specially enter lung, holds concurrently to deliver, white in peeling, lighter void floats, and also removes pathogen of the lung ear.Modern study analysis shows, Exocarpium Citri Rubrum contains various active material, and mainly comprise flavone compound, volatile oil, coumarin kind compound and polysaccharide etc., active component is high, and medical value is large.
Exocarpium Citri Grandis, i.e. Huajuhong are national geography sign protection product, and because it has unique stomach invigorating circulation of qi promoting, effect of preventing phlegm from forming and stopping coughing, the product thus about Exocarpium Citri Grandis is a lot of with research.CN201110029217.1 discloses a kind of Exocarpium Citri Grandis extract with hypoglycemic activity and preparation method thereof, uses specific extraction agent to extract positions such as Chinese crude drug Exocarpium Citri Grandis fruit, flowers, obtains the extract having and reduce blood glucose effect; CN02114847.3 discloses a kind of Exocarpium Citri Grandis preparation and production method thereof, by broken for Exocarpium Citri Grandis all-fruit powder, through water extraction one to three time, collect volatile oil simultaneously, filter, merging filtrate, add organic solvent be separated reconcentration or be directly condensed into extractum, dry, add adjuvant, add the volatile oil collected or do not add volatile oil and directly granulate, tabletting is made tablet or is made capsule; CN200410068888.9 discloses a kind of valiant fighter's cough mixture being used for the treatment for the treatment of cold due to wind-heat and preparation method thereof, its medicinal raw material contains Exocarpium Citri Grandis, also comprises Radix Platycodonis, Radix Glycyrrhizae, Flos Lonicerae, Folium Pyrrosiae, Fructus Arctii, Folium Isatidis, Cortex Lycii, Cortex Mori, Radix Asteris; CN200910039607.X additionally provides the novelty teabag of Exocarpium Citri Grandis in the medicine or health product of preparation control alcoholic liver injury.
The effects such as Folium Eriobotryae has diuresis, heat clearing away, quenches the thirst, antitussive, therefore, also the normal composition as eliminating phlegm and stopping cough together with Exocarpium Citri Grandis prepares medicine.CN200510038327.9 discloses a kind of antiinflammatory, cough-relieving, the Chinese medicine that reduces phlegm, is made up of raw materials such as Herba Houttuyniae, Rhizoma Fagopyri Dibotryis, Herba Hedyotidis Diffusae, Flos Magnoliae, Radix Glycyrrhizae, Pericarpium Metaplexis, Folium Eriobotryae (processed), Bombyx Batryticatus (parched), Exocarpium Citri Grandises; CN201010502286.5 discloses a kind of flu cough relief traditional Chinese medicine compositions, wherein just includes Exocarpium Citri Grandis and Folium Eriobotryae.But the eliminating phlegm and stopping cough effect of current most of related products is not fine, so it is good to develop a kind of comparitive study, have good eliminating phlegm and stopping cough function, for the patient of cough with copious phlegm, and the medicine effectively alleviating patient's misery becomes the emphasis of people's research and development.
Summary of the invention
The present invention is directed to prior art Problems existing, provide a kind of Juhongpipa Tablets, be prepared from for primary raw material with Exocarpium Citri Grandis, Pericarpium Citri Reticulatae, Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Pericarpium Citri Reticulatae, Radix Glycyrrhizae, eliminating phlegm and stopping cough is effective, can be used for treating cough with copious phlegm.
In order to solve the problem, the technical solution adopted in the present invention is:
A kind of Juhongpipa Tablets, the weight portion of each component of raw material is:
Exocarpium Citri Rubrum 10 ~ 20 parts, Pericarpium Citri Reticulatae 1 ~ 10 part, Folium Eriobotryae 10 ~ 20 parts, Radix Platycodonis 1 ~ 10 part, Fructus Perillae 1 ~ 10 part, 5 ~ 15 parts, Radix Glycyrrhizae, sugar 1 ~ 5 part, filler 15 ~ 25 parts, antiplastering aid 1 ~ 3 part.
Described Exocarpium Citri Rubrum is Exocarpium Citri Grandis.
Another object of the present invention is to provide a kind of preparation method of Juhongpipa Tablets, comprises the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 5 ~ 15 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 5 ~ 15 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 1 ~ 4 hour, filter, filtering residue adds 6 ~ 10 times amount soak by water 1 ~ 4 hour again, filter, leaching process temperature controls at 80 ~ 100 DEG C, and merge secondary decocting liquid, at 60 DEG C ~ 70 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 10 ~ 20 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
The usage of this product is as follows:
[character] this product is greyish white color chips; Gas fragrance.Taste is sweet, micro-hardship.
[function cures mainly] eliminating phlegm and stopping cough, for cough with copious phlegm.
[usage and dosage] is oral, one time 2 ~ 3,3 ~ 4 times on the one.
[points for attention]
1. avoid pungent food, greasy food.
2. this product is applicable to productive cough due to phlegm-damp, and it shows as cough recurrent exerbation, heavy cough, abundant expectoration, Se Bai or band Lycoperdon polymorphum Vitt.
3. bronchiectasis, lung abscess, pulmonary heart disease, lunger should take under doctor instructs.
4. take one week disease without improvement, should cut out, remove hospital admission.
5. period in a medicine, if high heat appears in patient, more than 38 DEG C, or there is dyspnea with rapid and short breath person out of breath in body temperature, or cough increases the weight of, and amount of expectoration showed increased person should go to see a doctor.
6. long-term taking, should to doctor or pharmacist's consulting.
7. pair this product allergy sufferers forbidding, allergic constitution person be cautious use of.
8. prohibit the use when this product character changes.
9. child must use under adult's monitoring.
10. please this product is placed on the place that child can not contact.
11. as used other medicines, please Ref Dr or pharmacist before using this product.
The present invention relative to the beneficial effect of prior art is:
(1) each component effect of raw material is as follows with effect:
Exocarpium Citri Grandis: outer surface yellow green, to yellowish-brown, has wrinkle and little grease chamber; Inner surface yellow-white or fallow, has venation stricture of vagina.Matter is crisp, frangibility.Gas fragrance, bitter in the mouth, micro-pungent; Function cures mainly: cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.
Pericarpium Citri Reticulatae: bitter in the mouth, pungent, warm in nature; Return lung, spleen channel; Regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; For distension and fullness in the abdomen, lack of appetite and vomiting, cough with copious phlegm.
Folium Eriobotryae: there is diuresis, heat clearing away, quench the thirst, the effect such as antitussive.
Radix Platycodonis: function cures mainly: lung qi dispersing, sore-throat relieving, eliminates the phlegm, evacuation of pus; For cough with copious phlegm, uncomfortable in chest not smooth, pharyngalgia, hoarseness, lung abscess vomiting pus, skin infection pus becomes.
Fructus Perillae: acrid in the mouth, warm in nature; Return lung meridian; The expectorant of effect sending down the abnormal ascending QI, relieving cough and asthma, intestine moistening.
Radix Glycyrrhizae: sweet in the mouth is put down; Main the five internal organs six mansion cold and heat pathogen, hard muscles and bones, longue meat, times power, gold wound, removing toxic substances; Clothes of a specified duration are made light of one's life by commiting suicide and are prolonged life.
Detailed description of the invention
Be described in further details the present invention below by embodiment, these embodiments are only used for the present invention is described, do not limit the scope of the invention.
embodiment 1:
A kind of Juhongpipa Tablets, the weight portion of each component of raw material is:
Exocarpium Citri Rubrum 10 parts, Pericarpium Citri Reticulatae 1 part, Folium Eriobotryae 10 parts, Radix Platycodonis 1 part, Fructus Perillae 1 part, 5 parts, Radix Glycyrrhizae, sugar 1 part, filler 15 parts, antiplastering aid 1 part.
Its preparation method, comprises the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 5 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 5 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 1 hour, filter, filtering residue adds 6 times amount soak by water 1 hour again, filter, leaching process temperature controls at 80 DEG C, and merge secondary decocting liquid, at 60 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 10 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
embodiment 2:
A kind of Juhongpipa Tablets, the weight portion of each component of raw material is:
Exocarpium Citri Rubrum 20 parts, Pericarpium Citri Reticulatae 10 parts, Folium Eriobotryae 20 parts, Radix Platycodonis 10 parts, Fructus Perillae 10 parts, 15 parts, Radix Glycyrrhizae, sugar 5 parts, filler 25 parts, antiplastering aid 3 parts.
Its preparation method, comprises the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 15 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 15 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 4 hours, filter, filtering residue adds 10 times amount soak by water 4 hours again, filter, leaching process temperature controls at 100 DEG C, and merge secondary decocting liquid, at 70 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 20 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
embodiment 3:
A kind of Juhongpipa Tablets, the weight portion of each component of raw material is:
Exocarpium Citri Rubrum 15 parts, Pericarpium Citri Reticulatae 5 parts, Folium Eriobotryae 15 parts, Radix Platycodonis 5 parts, Fructus Perillae 5 parts, 10 parts, Radix Glycyrrhizae, sugar 3 parts, filler 20 parts, antiplastering aid 2 parts.
Its preparation method, comprises the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 10 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 10 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 3 hours, filter, filtering residue adds 8 times amount soak by water 3 hours again, filter, leaching process temperature controls at 90 DEG C, and merge secondary decocting liquid, at 65 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 15 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
embodiment 4:
A kind of Juhongpipa Tablets, the weight portion of each component of raw material is:
Exocarpium Citri Rubrum 13 parts, Pericarpium Citri Reticulatae 3 parts, Folium Eriobotryae 12 parts, Radix Platycodonis 2 parts, Fructus Perillae 3 parts, 7 parts, Radix Glycyrrhizae, sugar 2 parts, filler 16 parts, antiplastering aid 1.5 parts.
Its preparation method, comprises the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 9 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 8 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 1 ~ 4 hour, filter, filtering residue adds 7 times amount soak by water 2 hours again, filter, leaching process temperature controls at 85 DEG C, and merge secondary decocting liquid, at 63 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 11 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
embodiment 5:
A kind of Juhongpipa Tablets, the weight portion of each component of raw material is:
Exocarpium Citri Rubrum 18 parts, Pericarpium Citri Reticulatae 9 parts, Folium Eriobotryae 16 parts, Radix Platycodonis 7 parts, Fructus Perillae 7 parts, 13 parts, Radix Glycyrrhizae, sugar 4 parts, filler 21 parts, antiplastering aid 2.5 parts.
Its preparation method, comprises the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 13 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 14 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 3.5 hours, filter, filtering residue adds 8 times amount soak by water 3 hours again, filter, leaching process temperature controls at 95 DEG C, and merge secondary decocting liquid, at 68 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 17 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
Claims (3)
1. a Juhongpipa Tablets, is characterized in that: the weight portion of each component is:
Exocarpium Citri Rubrum 10 ~ 20 parts, Pericarpium Citri Reticulatae 1 ~ 10 part, Folium Eriobotryae 10 ~ 20 parts, Radix Platycodonis 1 ~ 10 part, Fructus Perillae 1 ~ 10 part, 5 ~ 15 parts, Radix Glycyrrhizae, sugar 1 ~ 5 part, filler 15 ~ 25 parts, antiplastering aid 1 ~ 3 part.
2. a kind of Juhongpipa Tablets according to claim 1, is characterized in that: described Exocarpium Citri Rubrum, is Exocarpium Citri Grandis.
3. a preparation method for Juhongpipa Tablets, is characterized in that: comprise the following steps:
By Exocarpium Citri Rubrum, Pericarpium Citri Reticulatae, add 5 ~ 15 times of water gagings, decoct, collect volatile oil; The medical materials such as Folium Eriobotryae, Radix Platycodonis, Fructus Perillae, Radix Glycyrrhizae are added upper step have been extracted in the medicinal residues of volatile oil, add 5 ~ 15 times of water gagings (comprising the residue water liquid after having extracted volatile oil) and decoct 1 ~ 4 hour, filter, filtering residue adds 6 ~ 10 times amount soak by water 1 ~ 4 hour again, filter, leaching process temperature controls at 80 ~ 100 DEG C, and merge secondary decocting liquid, at 60 DEG C ~ 70 DEG C, concentrating under reduced pressure becomes thick paste; Thick paste and sugar, filler are mixed in wet granulator, add dehydrated alcohol and make moist wood, moist wood is poured oscillating granulator into and is made granule; cross 10 ~ 20 order shaking screens after particle drying and carry out granulate, spray adds extracts gained volatile oil, mixing; add antiplastering aid, pack after tabletting, film coating and get final product.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410813291.6A CN104435260A (en) | 2014-12-24 | 2014-12-24 | Red tangerine peel and loquat tablets and preparation method thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410813291.6A CN104435260A (en) | 2014-12-24 | 2014-12-24 | Red tangerine peel and loquat tablets and preparation method thereof |
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| CN104435260A true CN104435260A (en) | 2015-03-25 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106723041A (en) * | 2016-12-28 | 2017-05-31 | 广东石油化工学院 | A kind of Exocarpium Citri Grandis guttural tablets and preparation method thereof |
| CN116688072A (en) * | 2023-06-30 | 2023-09-05 | 河南宝丽邦医疗科技有限公司 | Essential oil for relieving cough and reducing sputum and preparation method thereof |
-
2014
- 2014-12-24 CN CN201410813291.6A patent/CN104435260A/en active Pending
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106723041A (en) * | 2016-12-28 | 2017-05-31 | 广东石油化工学院 | A kind of Exocarpium Citri Grandis guttural tablets and preparation method thereof |
| CN116688072A (en) * | 2023-06-30 | 2023-09-05 | 河南宝丽邦医疗科技有限公司 | Essential oil for relieving cough and reducing sputum and preparation method thereof |
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Application publication date: 20150325 |