CN104435141B - 一种含鬼箭羽的治疗糖尿病的中药组合物 - Google Patents
一种含鬼箭羽的治疗糖尿病的中药组合物 Download PDFInfo
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Abstract
本发明属于医药技术领域，涉及一种中药组合物，具体涉及一种含鬼箭羽的治疗糖尿病的中药组合物。本发明的治疗糖尿病的中药组合物是由以下重量配比的药用原料制备而成：黄芪7～25份、苦荞麦茎6～20份、龙牙楤木3～10份、忍冬藤3～10份、桑葚3～10份、鬼箭羽1～5份、甘草1～5份。本发明治疗糖尿病的中药组合物，7味药用原料按配方比例组合治疗糖尿病具有协同增效功能，用于治疗糖尿病疗效显著且对患者身体无副作用。
Description
技术领域
本发明属于医药技术领域，涉及一种中药组合物，具体涉及一种含鬼箭羽的治疗糖尿病的中药组合物。
背景技术
糖尿病是一组以高血糖为特征的代谢性疾病，是我国发病率高，危害严重的流行病之一。糖尿病时长期存在的高血糖，导致各种组织，特别是眼、肾、心脏、血管、神经的慢性损害、功能障碍，引发各种糖尿病并发症。据统计，糖尿病并发症的死亡率仅次于心血管病、脑血管病和肿瘤，居第四位。中国糖尿病患者数量已接近4000万人，居世界第三，与20世纪80年代的0.7％相比，增长了5倍。糖尿病可由遗传和环境因素相互作用而引起，常见症状有多饮、多尿、多食以及消瘦等。糖尿病可引起身体多系统的损害；引起胰岛素绝对或相对分泌不足以及靶组织细胞对胰岛素敏感性降低；引起蛋白质、脂肪、水和电解质等一系列代谢紊乱综合征，其中以高血糖为主要标志。目前治疗糖尿病的药很多，尤其是西药，但副作用大，而中成药效果不够显著。
发明内容
本发明的目的提供一种含鬼箭羽的治疗糖尿病的中药组合物，该中药组合物疗效好、对人身体副作用小。
为了实现上述发明目的，本发明提供了以下技术方案：
一种含鬼箭羽的治疗糖尿病的中药组合物，是由以下重量配比的药用原料制备而成：黄芪7～25份、苦荞麦茎6～20份、龙牙楤木3～10份、忍冬藤3～10份、桑葚3～10份、鬼箭羽1～5份、甘草1～5份。所述各种药用原料均为符合国家或地方标准规定的中药材。
优选的，上述药用原料中，黄芪所占重量比例为12～18份。更优选的，黄芪所占重量比例为15份。
优选的，上述药用原料中，苦荞麦茎所占重量比例为9～15份。更优选的，苦荞麦茎所占重量比例为12份。
优选的，上述药用原料中，龙牙楤木所占重量比例为5～7份。更优选的，龙牙楤木所占重量比例为6份。
优选的，上述药用原料中，忍冬藤所占重量比例为5～7份。更优选的，忍冬藤所占重量比例为6份。
优选的，上述药用原料中，桑葚所占重量比例为5～7份。更优选的，桑葚所占重量比例为6份。
优选的，上述药用原料中，鬼箭羽所占重量比例为2～4份。更优选的，鬼箭羽所占重量比例为3份。
优选的，上述药用原料中，甘草所占重量比例为2～4份。更优选的，甘草所占重量比例为3份。
本发明的治疗糖尿病的中药组合物，可以按照常规的中药提取方法提取药用原料的活性组分，如加水煎煮，或用乙醇或乙醇的水溶液回流提取并收集提取液并浓缩；再加上药学上可接受的载体或/和辅料，如淀粉、糊精、微晶纤维、可压性淀粉、硬脂酸镁、微粉硅胶、蔗糖、羧甲基淀粉钠、羟丙基甲基纤维素、植物油、卵磷脂、聚乙二醇、丙二醇、尼泊金乙酯等，制成药剂学上适宜的剂型，如颗粒剂、片剂、硬胶囊、口服液、软胶囊、滴丸、水泛丸等。
与现有技术相比，本发明的有益效果：
本发明治疗糖尿病的中药组合物，是发明人基于祖国医学对糖尿病的发病机理的认识，根据自己多年临床经验，先从众多中药中确定一系列对治疗糖尿病有效的中药，再经临床反复验证而筛选出来的。其中，黄芪，黄芪甘温升补，入脾、肺经；主以扶正气，兼能除水邪；既善补中气、升举清阳，又善补肺气、益气固表，还能托疮毒、利水消肿。苦荞麦茎，味甘苦，性平，归脾、胃、大肠经；具有健脾行滞、理气止痛、解毒消肿之功效；用于胃脘胀痛、消化不良、痢疾、腰腿痛、跌打损伤、痈肿恶疮等症。龙牙楤木，别名刺老鸦、虎阳刺、刺龙牙；为五加科楤木属植物辽东楤木，以根皮入药；味甘、苦，性平；具有健胃、利水、祛风除湿、活血止痛等功效；用于胃、十二指肠溃疡，慢性胃炎，肝炎，糖尿病，风湿性关节炎，水肿等症。忍冬藤，别名忍冬、银花藤、金银藤；为忍冬科植物忍冬的干燥茎枝；甘，寒；归肺、胃经；具有清热解毒、疏风通络的功效；用于温病发热，热毒血痢，痈肿疮疡，风湿热痹，关节红肿热痛等症。桑葚，又名桑椹，为桑科植物桑的干燥果穗。甘、酸，寒；归心、肝、肾经；具有补血滋阴、生津润燥的功效；用于眩晕耳鸣，心悸失眠，须发早白，津伤口渴，内热消渴，血虚便秘等症。鬼箭羽，别名卫矛、鬼箭(《本经》)，神箭(《广雅》)，风枪林(《中国药植志》)，山鸡条子(《东北药植志》)，四面戟(《药材学》)等；为卫矛科植物卫矛的具翅状物的枝条或翅状附属物；苦，寒；"入足厥阴经。"具有破血，通经，杀虫的功效；用于治经闭，症瘕，产后瘀滞腹痛，虫积腹痛等。甘草，味甘性平；归心、肺、脾、胃经。具有补脾益气，清热解毒，祛痰止咳，缓急止痛，调和诸药之功效。用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多，脘腹、四肢挛急疼痛，痈肿疮毒、缓解药物毒性、烈性。上述7味中草药按配方比例混合后，按照常规的中药提取方法提取药用原料的活性组分后得到本发明的治疗糖尿病的中药组合物。其中的7味药按配方比例组合后，治疗糖尿病具有协同增效的功能，能显著降低血糖、血脂浓度，提高血流量和抗氧化功效，治疗糖尿病效果显著且无毒副作用。
具体实施方式
下面结合试验例及具体实施方式对本发明作进一步的详细描述。但不应将此理解为本发明上述主题的范围仅限于以下的实施例，凡基于本发明内容所实现的技术均属于本发明的范围。
实施例1
本实施例的治疗糖尿病的中药组合物，是由以下重量配比的药用原料制备而成：黄芪15g、苦荞麦茎12g、龙牙楤木6g、忍冬藤6g、桑葚6g、鬼箭羽3g、甘草3g。
上述药用原料的提取方法：按配方比例取药用原料，向药用原料中加水煎煮2次，2次煎煮的用水体积依次为药用原料体积的10倍和8倍，2次煎煮时间依次为1.5小时和1小时，每次煎煮后过滤并收集滤液；合并2次滤液，得到实施例1药用原料的提取液，将实施例1药用原料的提取液浓缩至相对密度1.20(80℃)，得实施例1的提取物。
向上述提取物中加入提取物2倍重量的可溶性淀粉，制粒、干燥，分装成袋，得到实施例1治疗糖尿病的中药组合物颗粒剂。
实施例2
本实施例的治疗糖尿病的中药组合物，是由以下重量配比的药用原料制备而成：黄芪25g、苦荞麦茎6g、龙牙楤木10g、忍冬藤3g、桑葚3g、鬼箭羽5g、甘草3g。
上述药用原料的提取方法同实施例1。
实施例3
本实施例的治疗糖尿病的中药组合物，是由以下重量配比的药用原料制备而成：黄芪18g、苦荞麦茎13g、龙牙楤木7g、忍冬藤8g、桑葚5g、鬼箭羽2g、甘草2g。
上述药用原料的提取方法同实施例1。
对比例
本实施例的治疗糖尿病的中药组合物，是由以下重量配比的药用原料制备而成：黄芪15g、苦荞麦茎12g、龙牙楤木6g、忍冬藤6g、桑葚6g、甘草3g。
上述药用原料的提取方法同实施例1。
药效学试验证明：
为了证实本发明药物的疗效和安全性，发明人进行了药效学和毒性试验考察。所采用的研究方法及试验结果如下：
1、试验材料
(1)药物及试剂：
根据实施例1制备的本发明中药组合物；
根据对比例制备的对比例中药组合物；
四氧嘧啶，SIGMA Co.生产；
葡萄糖测定试剂盒，由北京化工厂生产；
降糖灵，市售。
(2)动物：昆明种小鼠，由四川抗菌素研究所实验动物中心提供。
(3)仪器：VZS-723分光光度计，电子天平等。
2、试验方法与结果：
(一)本发明药物对四氧嘧啶性糖尿病小鼠高血糖的影响
(1)、造高血糖模型与分组
取体重25±1g昆明种雄性小鼠80只，禁食不禁水。3小时后，尾静脉注射四氧嘧啶生理盐水注射液85mg/kg(0.5ml/只)造成高血糖模型，另将15只体重25±1g昆明种雄性小鼠尾静脉注射等量生理盐水(0.5ml/只)，做为正常对照动物。72小时后，将上述小鼠禁食不禁水10小时；然后自其眼眶取血，葡萄糖氧化酶法测每只小鼠血糖浓度。
从80只注射四氧嘧啶生理盐水注射液的小鼠中选择血糖高于200mg/dL且血糖值相近的60只，随机分为4组，即模型组、本发明药物组、对照组1及降糖灵组，每组15只。
(2)、给药、测血糖浓度
五组小鼠分别按下述方法灌胃给药和生理盐水：对本发明药物组灌胃本发明实施例1制备的中药组合物，用药总剂量：7g/kg(生药材)；对降糖灵组灌胃降糖灵，用药总剂量：80mg/kg；对对照组1灌胃本发明对比例制备的中药组合物，用药总剂量：7g/kg(生药材)；对模型组灌服等溶媒量的生理盐水；生理盐水组灌服等溶媒量的生理盐水。
连续给药10天，给药期间及前后观察各组的小鼠的摄食、活动及排泄情况均无异常情况发生。于第10天给药1小时后，眼眶取血，测空腹血糖浓度(禁食不禁水10小时，方法同前述)。比较对照组1与模型组之间，各给药组之间差异，结果见表1。
表1
注：表1中，与模型组比较:▲▲▲P＜0.001,▲▲P＜0.05，▲P＞0.05。
表1中实验结果表明：小鼠静脉注射四氧嘧啶72小时后，小鼠高血糖造模成功，其血糖浓度显著高于生理盐水组。用本发明药物组连续给药10天后，小鼠血糖浓度降为385.2±33.1mg/dL，比模型组的小鼠血糖浓度446.4±42.3mg/dL低61mg/dL左右。且本发明药物组的统计结果相对于模型组的的统计结果P＜0.05，具有显著性差异，本发明的药物组对四氧嘧啶性糖尿病小鼠高血糖的降血糖治疗效果好；且小鼠给药期间及前后无不良反应，本发明的治疗糖尿病的中药组合物治疗糖尿病对患者身体副作用小。
而对照组1连续给药10天后，小鼠血糖浓度为424.3±95.3mg/dL，比模型组的小鼠血糖浓度446.4±42.3mg/dL低22mg/dL左右；比本发明药物组小鼠血糖浓度的统计值385.2±33.1mg/dL高39mg/dL左右；且对照组1的统计结果相对于模型组的统计结果P＞0.05，无显著性差异。故得知，对比例制备的中药组合物对四氧嘧啶性糖尿病小鼠高血糖的降血糖治疗效果差。
综上，本发明治疗糖尿病的中药组合物，治疗糖尿病疗效好、见效快且对身体无副作用，7味药用原料按配方比例组合后，具有协同增效功能；缺少任意组分，中药组合物治疗糖尿病的疗效都会明显降低，如上述药效学试验中，对照组1的治疗效果相对于本发明药物组的疗效明显降低，且本发明的治疗糖尿病的中药组合物治疗糖尿病对患者身体副作用小。
Claims (3)
1.一种含鬼箭羽的治疗糖尿病的中药组合物，其特征在于：它是由以下重量配比的药用原料制成：黄芪12～18份、苦荞麦茎9～15份、龙牙楤木5～7份、忍冬藤5～7份、桑葚5～7份、鬼箭羽2～4份、甘草2～4份。
2.根据权利要求1所述的治疗糖尿病的中药组合物，其特征在于：龙牙楤木所占重量比例为6份。
3.根据权利要求1所述的治疗糖尿病的中药组合物，其特征在于：鬼箭羽所占重量比例为3份。
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