CN104414914A - Striae gravidarum recovery essence - Google Patents

Abstract

The invention relates to a striae gravidarum recovery essence. The striae gravidarum recovery essence is compounded from pure natural plant extract ingredients, non-toxic, gentle and non-irritant to the skin. The striae gravidarum recovery essence belongs to the field of fine daily functional skin-care products. The striae gravidarum recovery essence mainly provides nursing care and recovery functions for the skins of pregnant and lying-in women, obesity crowd and scar sequela crowd, can be used in daily families, beauty salons, plastic surgery hospitals, confinement care centers, scar recovery centers, rehabilitation and healthcare centers, fitness centers and bath centers for fading and thinning striae gravidarum, moving cracks, obesity marks and scar marks caused by the processes of pregnancy, fitness, weight gain and injuries, has the functions of resisting bacteria and diminishing inflammation, promoting wound healing, and replenishing water and moisturizing, and can be used for repairing various scars including scars caused by caesarean, reducing the chromatosis of the scars, improving the blood circulation of the skin, improving skin colour and skin quality, and improving skin elasticity. The striae gravidarum recovery essence is a daily skin-care product with a medical cosmetology function.

Description

A kind of striae gravidarum repairs essence

technical fieldthe present invention relates to a kind of striae gravidarum and repair essence, the main component of formula is Herba Centellae extracting solution, β-oat beta-glucan, Camellia oil, fruit acid, Pericarpium Granati extracting solution, Aloe extraction solution, triethanolamine, glycerol, propylene glycol, is prepared from through special process.Belong to meticulous daily function skin care field.Be mainly pregnant and lying-in women, nursing health repair that obese people, cicatrix sequela crowd provide skin, can everyday home, beauty parlor, cosmetic surgery hospital, puerperal period care centre, scar repairing center, rehabilitation center, fitness center, bath center use, pregnancy, body-building, body weight increases suddenly, injured process causes striae gravidarum, moving crack, obesity striae, cicatrix stricture of vagina are desalinated and refinement, lower pigmentation, reduce the cicatrix crackle of skin, promote that the broken fiber of skin heals as far as possible.Except the skin crackles such as reparation striae gravidarum, the present invention also has anti-inflammation, promotes the effect of wound healing, replenishing water and preserving moisture, can be used for repairing cesarean at interior various cicatrixes, reduce cicatrix pigmentation, improve cutaneous circulation, improve the colour of skin and skin quality, increasing skin elasticity, is the daily skin care item with medical and beauty treatment function.

background technologystriae gravidarum is also called " skin expansion stricture of vagina ", the damage because the bulge of During Pregnancy midriff makes the elastic fibers of skin and collagen fiber be subject in various degree because of external force tractive or fracture, thinning of skin attenuates, and occurs some width difference, pink different in size or mauve wavy decorative patterns.Its formation mainly affects by trimester of pregnancy hormone, and point these decorative patterns of puerperium can fade away, and leaves white or argenteous glossiness cicatrix strain line, i.e. striae gravidarum.Striae gravidarum is the one of striae atrophicae, and striae atrophicae is the skin fiber phenomenon of rupture that human body produces in the middle of pregnancy, body-building, the rapid increasing process of body weight, take on a red color, white or purple fringe.It also comprises obesity striae, moving crack, the body part that motion amplitude is larger, except abdominal part, also has outside in stock, knee, buttocks, the positions such as waist sacrum.No matter be striae gravidarum, or striae atrophicae, its streak cicatrix outward appearance allows many female friends extremely perplex.Due to the distinctive intractable of cicatrix, make striae gravidarum clear-cutting forestland almost unlikely.

The existing various product for striae gravidarum, scar repairing is emerge in an endless stream on the market, and key factor is in following two series products, and a kind of is main component with plants essential oil, the oiliness of quintessence oil is utilized to unfold skin, the moisturizing of lock water, improves the grain roughness of skin, promotes collagen protein synthesis in body; Another kind is main component with fruit acid, makes papillary layer of corium connective tissue thinning, hypopigmentation, skin moisturizing, alleviates wrinkle and aging.These products existing main onset composition is single, and other composition in its formula mostly is ordinary cosmetics composition, only can play the effect of moisturizing, lock water, whitening, skin moistening, but often onset is very micro-to the elimination of striae gravidarum etc.Scientific research shows, Herba Centellae, β-oat beta-glucan, Camellia oil, Aloe extraction solution all have good scar repairing function, and wherein the repair of Herba Centellae and β-oat beta-glucan is particularly outstanding.Herba Centellae extract can promote the synthesis of collagen protein I and III, also can promote the secretion of mucopolysaccharide (as hyaluronic synthesis) simultaneously, increases the water conservation degree of skin, and activation upgrades Skin Cell, skin is releived, promotes and be rich in reflecting feel; Arrange testing research by cDNA on the other hand also to find, Herba Centellae extract also has the activation of fibroblast gene, can strengthen the vigor of skin basal layer cell, keeps elasticity of skin and consolidation sense, level and smooth face fine wrinkles.β-oat beta-glucan has unique straight-chain molecular structure, imparts good Transdermal absorption performance; Promote fibroblast synthesis collagen protein, promote wound healing, repair impaired skin, give skin and moisten smooth sense of touch as silk.

Present invention employs above-mentioned multiple natural botanical extraction liquid composition, make scar repairing effect more effectively lasting by rationally composite, add many emulsifying, moisturizing, solvent composition, and utilize the Antimicrobial preservative of Pericarpium Granati extracting solution to add as antiseptic of the present invention, avoid the use of synthetic preservative.The biological preparation that formula of the present invention all adopts Pure natural nontoxic harmless, effectively can prevent, desalinate, repair, refinement striae gravidarum, obesity striae and moving crack; Promote wound healing, anti-inflammation, repair cesarean cicatrix, reduce cicatrix pigmentation, improve cutaneous circulation, improve the colour of skin and skin quality, increase skin elasticity.

summary of the inventionthe invention provides a kind of striae gravidarum and repair essence, its main points are to adopt Herba Centellae, β-oat beta-glucan, Camellia oil, fruit acid, Pericarpium Granati, the multiple pure biological components of Aloe and various emulsifying, moisturizing, solvent mutually composite, are prepared from by special process.A kind of striae gravidarum repairs the formula following (component and percentage by weight %) of essence: Herba Centellae extracting solution 4-6, β-oat beta-glucan 2-4, Camellia oil 5-8, fruit acid 1-3, Pericarpium Granati extracting solution 3-5, Aloe extraction solution 1-3, triethanolamine 0.3-0.8, glycerol 4-6, propylene glycol 5-8, soft water add to 100.

Herba Centellae is the dry herb of samphire Herba Centellae, have another name called Glechota longituba (Nakai) Kupr, Gotu Kola etc., for the perennial herbaceous plant that crawls, often crispatura into bulk, its stem is elongated, and tuberosity is taken root, and originates in India, now be distributed widely in the torrid zone, the world, subtropical zone district, be mainly distributed in each province on the south the Changjiang river in China.Herba Centellae happiness is born in moistening riverbank, marsh, meadow.Modern pharmacology research shows, Herba Centellae extract has stronger antibacterial, antiinflammatory, the synthesis of promotion fibroblast and collagenocyte, the effect of repairing cicatrix, improving the colour of skin.Herba Centellae extract is asiatic acid and Madecassic acid, asiaticoside and asiaticoside for the main active of kind of making up.1, antibacterial action: asiatic acid and Madecassic acid belong to active saponin material, the Cytoplasm in meeting acidifying plant cell, thus protective plant self resists the invasion and attack of yeast and mold.Experiment shows that Herba Centellae extract all has certain inhibitory action to bacillus pyocyaneus, staphylococcus aureus, Propiobacterium etc.2, antiinflammation: Herba Centellae extract can reduce the generation of proinflammatory medium IL-1, improves and repairs skin self barrier function, thus prevent and correct skin immunologic function disorder.3, the anabolic effect of fibroblast and collagenocyte is promoted: the people such as Lv Luo found through experiments, after the application asiaticoside of various dose and asiaticoside act on fibroblast. in vitro culture, the former and former content of type III precollagen amino terminal peptide by I procollagen type amino terminal peptide in the method determination experiment group of radioimmunity and blank group cell conditioned medium liquid.Result shows: (1), compared with blank group, asiaticoside and asiaticoside can the former secretions of effective stimulus In vitro culture HSFb peptide; (2) asiaticoside and asiaticoside stimulate the biological action of target cell secretion to present obvious dose-effect relationship; Test shows that Herba Centellae extract significantly can promote the synthesis of fibroblast and collagen protein.4, cicatrix repair: the pharmacological research that Chinese scholars is done shows, Herba Centellae extract has outstanding healing of wound and cicatrix repair, its reason is that asiaticoside has and promotes collage synthesis and the important function such as new vascular generation, the growth of stimulation granulation in body, so be conducive to wound healing.As continuous administration, containing the preparation of asiaticoside, can prevent wound infection from suppurating on skin wound, shorten wound healing time, skin hardness can be reduced and improve skin-nourishing, the effect of enhancing metabolism.The people such as Pan Shu cultivate people's fibroblasts from hypertrophic scars with tissue block method, adopt flow cytometry, its change of cell cycle and the change of phosphorylation Smad2 and Smad7 after normal condition and application asiaticoside of immunocytology chemical detection.Result proves, asiaticoside suppresses the effect of cicatrix by Smad path.Be derived from natural Herba Centellae elite, be commonly called as " plant collagen ", be applicable to very much the treatment of damaged skin.Beyer Co., Ltd carries out double blinding human test to the women volunteer of 40 existing striae gravidarum, smears twice every day with the oil/water/oil formula containing 1% Herba Centellae extract, continues 3 months, result shows, the width of striae gravidarum reduces 26%, and length reduces 40%, color reduction 50%.5, colour of skin effect is improved: Herba Centellae extract has stronger antioxidation, free radical activity can be suppressed, desalinate melanin pigmentation, improve skin blood circulation, upgrade skin cell regeneration, help melanin smooth metabolism to go out external, make the smooth delicacy of skin, whitening beautiful.

β-oat beta-glucan is a kind of natural non-starch class water-soluble plant sugar be present in large oat hull, and its basic structure is the linear polysaccharide be formed by connecting with β 14, β 1-3 glycosidic bond by D glucose, and the ratio of these two kinds of glycosidic bonds is roughly 7:3.

As the effective ingredient of cosmetics, β-oat beta-glucan can improve resisting skin allergy ability, activate immunity function, delay skin aging.β-oat beta-glucan can accelerate the immunocyte determining crowd, alleviates the reaction of bacteriological infection and controls the position of bacteriological infection, infection face is recovered as early as possible; β-oat beta-glucan has excellent senile-resistant efficacy, can smooth fine wrinkles, improves skin elasticity, improves skin texture degree; There is unique straight-chain molecular structure, impart good Transdermal absorption performance; Promote fibroblast synthesis collagen protein, promote wound healing, repair impaired skin, give skin and moisten smooth sense of touch as silk.

Camellia oil is commonly called as Oleum Camelliae, has another name called Camellia oil, is the senior edible vegetable oil of pure natural extracted from the C. olelfera mature seed of Theaceae Camellia Plants.Camellia oil has uvioresistant, antibacterial, antiviral, kills effect of tinea furuncle, directly uses prevention, desalination, removal striae gravidarum, effect of preventing sunburn and wrinkle removing, preventing tinea capitis, tinea corporis, dandruff, alopecia.In addition Camellia oil also can be made ingredients in shampoo and hair conditioner and uses, and can prevent skin pruritus, drying, chap, the generation of chronic eczema.

As its name suggests, the various organic acid extracted from fruit exactly, are be present in the active ingredient in multiple natural fruit or Yoghourt, comprise Fructus Vitis viniferae acid, malic acid, citric acid and lactic acid etc. fruit acid, because great majority are by refining in fruit, therefore claim fruit acid.The high concentration fruit acid preparation outer used time, epidermis can be made to be separated with corium, Here it is cracking-off agent.The effect of stripping off of fruit acid preparation is gentleer, pigment anomaly can not occur more, more can not produce cicatrix.Fruit acid is natural organic acid, thus has no side effect to whole body. be a kind of nutrient substance to skin beneficiating, have good nourishing effect to skin.External fruit acid preparation can make epidermis thicken, and papillary layer of corium connective tissue is thinning, hypopigmentation, skin moisturizing, alleviates wrinkle and aging.Except above-mentioned effect, fruit acid can also improve skin texture.External fruit acid preparation can make the mast cell degranulation of high dermis, and the medium of retting conditions release stimulates intradermal fibroblast, chamber fibril and elastic fibers quantity is increased, skin is enriched again, springiness.Fruit acid can make telangiectasis, is improved the effect of cutaneous circulation, thus improves skin texture.

Pericarpium Granati another name Punica granatum L. shell, Tannin in Punica granatum L contributes to local woanded surface healing or protects local from stimulation.Inhibitory action in various degree is all had, wherein again with the strongest to Bacillus typhi, dysentery bacterium effect to staphylococcus aureus, Hemolytic streptococcus, Bacillus typhi, Salmonella paratyphi, vibrio cholera, escherichia coli, Bacillus proteus, bacillus pyocyaneus, tubercule bacillus, meningococcus, helicobacter pylori, gonococcus, various dysentery bacteriums etc.Pericarpium Granati water logging agent also has inhibitory action in various degree to multiple pathomycete.Tannin in Punica granatum L is the effective ingredient of anti-genitals herpesvirus, and it can not only suppress virus in intracellular propagation, also has the effect of direct kill virus and its adherent cell of prevention.Pericarpium Granati decoct has inhibitory action to PR8 strain of influenza virus type A influenza virus.Pericarpium Granati Aqueous extracts has antivirus to HBV.

Aloe, Liliaceae, Aloe, perennial evergreen plant, leaf is plump greatly, and from leaf, adopt juice can be used as medicine.Aloe bitter in the mouth, cold in nature, include anthraquinone derivative, Aloe Radix Et Rhizoma Rhei, Saponin, aminoacid and polysaccharide.Aloe mainly contains nourishing and moisturizing in cosmetics, anti-sunlight function, and therefore Aloe is extensively suitable in the moisturizing wrinkle-removal cosmetic product such as cream frost, emulsion, cleansing milk, facial film.Its main mechanism is with lock water effect mechanism, (1) natural moisturizing promotes that NMF falls in fibrous polymer albumen, thus increases nature moisturizing factor, immediately increases water content, reduces percutaneous water loss (28 days reduce 20%) by slight filming function; (2) the smooth hygroscopic mem-brane of one deck being formed at skin surface, promoting beautiful feeling and the flexibility of formula when not increasing viscosity, because being rich in polysaccharide and the effect of releiving; (3) antiinflammatory and healing of wound effect, embedded biometric enzyme, by being slowly hydrolyzed with skin, plays anti-inflammation and sterilization effect, and under aminoacid effect, with collagen effect in horny layer, healing of wound.

Triethanolamine is colourless to pale yellow transparent thick liquid, and micro-have ammonia taste, and become colourless to faint yellow cubic system crystal during low temperature, when being placed in air, color deepens gradually.Soluble in water, ethanol, acetone, glycerol and ethylene glycol etc., be slightly soluble in benzene, ether and carbon tetrachloride etc., dissolve hardly in non-polar solven.Emulsifying agent, wetting agent, humidizer, thickening agent, PH poising agent is used as in cosmetic formulations.The gel phase good stability that triethanolamine and higher fatty acids or high fatty alcohol are formed, constant product quality, can hold additional ingredients proportion high.

Glycerol is water white transparency viscous liquid, is the product of Chemical Manufacture, has good water absorption, humectation, the property of softening, the extremely aobvious moisture absorbed in air, aqueous solution is in neutral, can mix with water, ethanol, methanol arbitrary proportion, be commonly used to the interpolation raw material making cosmetics.Propylene glycol is the stable water absorption liquid of colorless viscous, and almost tasteless odorless, can be used as wetting agent in cosmetics, softening agent, the uses such as solvent.

Preparation technology of the present invention is:

(1) preparation of Herba Centellae extracting solution: by Herba Centellae cleaning, dry, pulverizing, take powder 50g, put in 500ml round-bottomed flask, add 80% ethanol 200ml, soaking at room temperature 12 hours, 85 DEG C of water-bath circumfluence distillation 2 times, 20min first, the 2nd 10min, merge extractive liquid, cooling final vacuum sucking filtration, decompression recycling ethanol is extremely without alcohol taste; Added in preparative high performance liquid chromatography instrument by first for Herba Centellae extract, preparation parameter is as follows: the chromatographic column of employing is C18 post (50mm × 200mm, 5 μm), and mobile phase is methanol-water (volume ratio 60:40), flow velocity 100mL/min; Diode array detector detects at 220nm; After running 20min, the asiaticoside in Herba Centellae extracting solution, asiaticoside well can be separated with interference component, and extracting solution purity can reach more than 98%;

(2) by proportioning, described component Pericarpium Granati extracting solution, Aloe extraction solution, triethanolamine, glycerol, propylene glycol are added in deionized water, stir, heat to 50 DEG C, emulsifying 10min;

(3) by proportioning, described component Herba Centellae extracting solution, β-oat beta-glucan, Camellia oil are added in above-mentioned mixed liquor, stir;

(4) add in above-mentioned mixed liquor by proportioning by described component fruit acid, regulate solution pH value between 4.5-5.5, deionized water adds to 100, mix homogeneously;

(5) aseptic subpackaged after cooling, put preservation in storage after the assay was approved.

The invention has the beneficial effects as follows:

(1) promote the synthesis of fibroblast and collagen protein, effectively can prevent, alleviate, desalinate the striae gravidarum of skin, moving crack and obesity striae etc.; (2) promote collage synthesis and the effect such as new vascular generation, the growth of stimulation granulation in body, there is the effect of healing of wound and reparation cesarean cicatrix; (3) stronger antioxidation, can suppress free radical activity, desalinate melanin pigmentation, improves skin blood circulation, upgrade skin cell regeneration, help melanin smooth metabolism to go out external, makes the smooth delicacy of skin, whitening beautiful; (4) excellent senile-resistant efficacy, can smooth fine wrinkles, improves skin elasticity, improves skin texture degree; (5) uvioresistant, antibacterial, antiviral, kill tinea furuncle, prevent skin pruritus, drying, chap, the generation of chronic eczema; (6) reduce the generation of proinflammatory medium IL-1, there is antiinflammation; (7) water and moisture-keeping function is locked; (8) natural botanical extraction liquid formula, nontoxicly has no stimulation, and uses relieved.

detailed description of the inventionbelow in conjunction with embodiment, the present invention is described in further detail:

1, be configured according to data listed in Table (percentage by weight %) and affiliated step thereof:

Formula one:

Herba Centellae extracting solution 5-6, β-oat beta-glucan 3-4, Camellia oil 6-8, fruit acid 2-3, Pericarpium Granati extracting solution 4-5, Aloe extraction solution 2-3, triethanolamine 0.5-0.8, glycerol 5-6, propylene glycol 6-8, soft water add to 100.

Formula two:

Herba Centellae extracting solution 4-6, β-oat beta-glucan 2-4, Camellia oil 5-8, fruit acid 1-3, Pericarpium Granati extracting solution 3-5, Aloe extraction solution 1-3, triethanolamine 0.3-0.8, glycerol 4-6, propylene glycol 5-8, soft water add to 100.

Formula three:

Herba Centellae extracting solution 4-5, β-oat beta-glucan 2-3, Camellia oil 5-7, fruit acid 1-2, Pericarpium Granati extracting solution 3-4, Aloe extraction solution 1-2, triethanolamine 0.3-0.6, glycerol 4-5, propylene glycol 5-7, soft water add to 100.

Claims (2)

1. the present invention relates to a kind of striae gravidarum and repair essence, it is characterized in that adopting Herba Centellae, β-oat beta-glucan, Camellia oil, fruit acid, Pericarpium Granati, the multiple pure biological components of Aloe and various emulsifying, moisturizing, solvent mutually composite, be prepared from by special process; A kind of striae gravidarum repairs the formula following (component and percentage by weight %) of essence: Herba Centellae extracting solution 4-6, β-oat beta-glucan 2-4, Camellia oil 5-8, fruit acid 1-3, Pericarpium Granati extracting solution 3-5, Aloe extraction solution 1-3, triethanolamine 0.3-0.8, glycerol 4-6, propylene glycol 5-8, soft water add to 100.

2. a kind of striae gravidarum according to claim 1 repairs essence, it is characterized in that having following preparation technology:

(1) preparation of Herba Centellae extracting solution: by Herba Centellae cleaning, dry, pulverizing, take powder 50g, put in 500ml round-bottomed flask, add 80% ethanol 200ml, soaking at room temperature 12 hours, 85 DEG C of water-bath circumfluence distillation 2 times, 20min first, the 2nd 10min, merge extractive liquid, cooling final vacuum sucking filtration, decompression recycling ethanol is extremely without alcohol taste; Added in preparative high performance liquid chromatography instrument by first for Herba Centellae extract, preparation parameter is as follows: the chromatographic column of employing is C18 post (50mm × 200mm, 5 μm), and mobile phase is methanol-water (volume ratio 60:40), flow velocity 100mL/min; Diode array detector detects at 220nm; After running 20min, the asiaticoside in Herba Centellae extracting solution, asiaticoside well can be separated with interference component, and extracting solution purity can reach more than 98%;

(2) by proportioning, described component Pericarpium Granati extracting solution, Aloe extraction solution, triethanolamine, glycerol, propylene glycol are added in deionized water, stir, heat to 50 DEG C, emulsifying 10min;

(3) by proportioning, described component Herba Centellae extracting solution, β-oat beta-glucan, Camellia oil are added in above-mentioned mixed liquor, stir;

(4) add in above-mentioned mixed liquor by proportioning by described component fruit acid, regulate solution pH value between 4.5-5.5, deionized water adds to 100, mix homogeneously;

(5) aseptic subpackaged after cooling, put preservation in storage after the assay was approved.