CN104351254A - Nikkomycin and azoxystrobin-containing fungicidal composition - Google Patents
Nikkomycin and azoxystrobin-containing fungicidal composition Download PDFInfo
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- CN104351254A CN104351254A CN201410596417.9A CN201410596417A CN104351254A CN 104351254 A CN104351254 A CN 104351254A CN 201410596417 A CN201410596417 A CN 201410596417A CN 104351254 A CN104351254 A CN 104351254A
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- nikemycin
- bactericidal composition
- fluoxastrobin
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Abstract
The invention relates to a nikkomycin and azoxystrobin-containing fungicidal composition. The fungicidal composition comprises the active ingredients of nikkomycin and azoxystrobin, wherein the nikkomycin and the azoxystrobin are in the weight ratio of 1:40-5:1; the fungicidal composition comprises 2 to 80 percent of the two active ingredients based on the total weight, and the balance of the components which are allowed to be used and accepted in a pesticide. The fungicidal composition has an obvious synergistic effect; compared with a single dosage, the control effect is improved, the pesticide using amount is reduced, and the cost and the environmental pollution are reduced.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to a kind of bactericidal composition containing Nikemycin and Fluoxastrobin.
Background technology
Nikemycin is the metabolite of streptomyces ansochromogenes 7100 generation that Institute of Microorganism, Academia Sinica is separated to from the soil of northeast, belongs to broad spectrum activity biogenic bactericide, has preventive and therapeutic action concurrently.Nikemycin is inhibited to chitin synthesis in fungal cell wall and insect shell, has good selective toxicity, very low to mammiferous toxicity.This medicine has good control efficiency to multiple fungal plant disease, insect and acarid, belongs to efficient, low toxicity, less-persistent pesticide, to plant without poisoning, to natural enemies security.
Nikemycin is applied separately and is easily made germ develop immunity to drugs, and is undertaken composite by different cultivars, effectively can prevent and treat germ pesticide resistance and produce.At present, the complex preparation product about Nikemycin is less, can not meet the control of producing upper disease.
The present invention utilizes existing pesticide species resource, is studied, and finds that Nikemycin and azoxystrobin compound have significant preventive effect to cladosporium leaf and fruit mould of tomato.
Fluoxastrobin is a kind of methoxy acrylic bactericide, has protection, treats and roots out triple role, has good crop safety and outstanding Environmental compatibility.Fluoxastrobin can suppress pathogen mitochondrial respiratory.Nikemycin can the chitinous synthesis of Antifungi cell wall.Both mechanism of action is completely different, to the effect of germ multidigit point, more easily can root out resistance germ, delay the generation of germ resistance after composite.
Summary of the invention
The bactericidal composition containing Nikemycin and Fluoxastrobin that the object of this invention is to provide that a kind of preventive effect is good, cost is low, can delay that germ resistance produces.
The object of the invention is to be achieved through the following technical solutions:
A kind of bactericidal composition containing Nikemycin and Fluoxastrobin, its active component is Nikemycin and Fluoxastrobin, wherein Nikemycin and Fluoxastrobin weight ratio are 1:40-5:1, and the gross weight percentage composition of two kinds of active components is 2-80%, and all the other are allow in agricultural chemicals to use and acceptable composition.
Bactericidal composition of the present invention can make any one formulation of applicable agricultural use, and preferred formulation is wetting powder, aqua and water dispersible granules.
Preferably, bactericidal composition of the present invention also comprises auxiliary agent, and described auxiliary agent comprises emulsifier, dispersant, wetting agent, disintegrant, binding agent etc., and be all conventional in pesticidal preparations or permission use, concrete auxiliary agent and consumption are determined according to recipe requirements.
Preferably, the weight ratio of described active component Nikemycin and Fluoxastrobin is 1:10-1:1, is more preferably 1:2.
Preferably, in described bactericidal composition, the gross weight percentage composition of active component is 2-60%; Be more preferably 12%.
Microbicide compositions of the present invention is applicable to prevent and treat Cereal, each planting fruit-trees, vegetable crop disease, as wheat powdery mildew, rice blast, Glomerella cingulata, cladosporium leaf and fruit mould of tomato, powdery mildew of strawberry, gray mold of cucumber etc., especially prevents and treats cladosporium leaf and fruit mould of tomato.
Bactericidal composition of the present invention can be prepared by the conventional method of prior art, compared to prior art, has following beneficial effect:
1. this bactericidal composition has obvious synergistic effect, and compared with single dose, preventive effect improves, and dosage reduces, and reduces cost and the pollution to environment.
2. the active ingredient mixture of two kinds of different mechanism of action, acts synergistically mutually, achieves excellent technique effect, is conducive to the pesticide resistance delaying germ.
Embodiment
In order to make object of the present invention, technical scheme and advantage clearly understand, the present invention is used for following specific embodiment and is described, but the present invention is limited to absolutely not these examples.
toxicity measures embodiment: Nikemycin and azoxystrobin compound are to cladosporium leaf and fruit mould of tomato Toxicity Determination
Subjects: Fulvia fulva, gathers diseased plant from the tomato greenhouse booth of emerging town, Pucheng County, carries out tissue and is separated, single spore separation.
Test method: adopt growth rate method.The expansion cultivation germ of 7 days is broken into the bacterium cake that diameter is 0.6cm, aseptically, is placed in the PDA culture medium flat plate central authorities containing different agents concentration, each process repetition 3 times, with the bacterium that the PDA medium of not adding medicine is cultivated for contrast.Be placed in after 25 DEG C of constant incubators cultivate 5 days, measure colony diameter by right-angled intersection method, calculate inhibition percentage, obtain virulence regression equation and the EC of each medicament
50.
Toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100
In theoretical toxicity index (TTI)=A medicament toxicity index × mixture A percentage composition+B medicament toxicity index x mixture in the percentage composition of B
Co-toxicity coefficient (CTC)=[theoretical toxicity index (TTI) × 100 of mixture actual measurement toxicity index (ATI)/mixture
When CTC≤80, then composition shows as Hangzhoupro short of money effect, and work as 80<CTC<120, then composition shows as summation action, and when CTC >=120, then composition shows as synergistic effect.
Result of the test: Toxicity Determination the results are shown in following table 1:
table 1 Nikemycin and azoxystrobin compound are to the Toxicity Determination result of cladosporium leaf and fruit mould of tomato
As can be seen from Table 1, Nikemycin and Fluoxastrobin are between proportioning 1:40-5:1, and co-toxicity coefficient is greater than 120, have synergistic effect to cladosporium leaf and fruit mould of tomato.Wherein proportioning is between 1:10-1:1, and co-toxicity coefficient is greater than 200, and synergistic effect is more remarkable.
Specify that Nikemycin and Fluoxastrobin have good synergistic effect so that certain proportion is composite by indoor biometrics test, further illustrate the present invention below by way of pharmaceutical formulation embodiment, but the present invention is only limitted to absolutely not following embodiment.
pharmaceutical formulation embodiment
Embodiment 1:2% Nikemycin Fluoxastrobin suspending agent
Ingredient names percentage by weight
Nikemycin (active ingredient) 1%
Fluoxastrobin (active ingredient) 1%
Naphthalenesulfonic acid-formaldehyde condensate (dispersant) 8%
Dodecyl sodium sulfate (wetting agent) 3%
Xanthans (thickener) 2%
Glycerine (antifreeze) 5%
Polyoxyethylene polyoxypropylene glycerin ether (defoamer) 2%
Water complements to 100%
The ratio of each components such as active component, dispersant, wetting agent, thickener, antifreeze, defoamer and water in formula mixed, it is broken to add sand mill medium sand abrasive dust, then drops in homogeneous still and obtain 2% Nikemycin Fluoxastrobin suspending agent after mixing.
Embodiment 2:60% Nikemycin Fluoxastrobin wetting powder
Ingredient names percentage by weight
Nikemycin (active ingredient) 50%
Fluoxastrobin (active ingredient) 10%
Lauryl sodium sulfate (wetting agent) 3%
Sodium lignin sulfonate (dispersant) 4%
White Carbon black (filler) 10%
Kaolin (filler) complements to 100%
The ratio in formula such as active ingredient, auxiliary agent and filler is fully mixed, mixes again after air-flow crushing and obtain 60% Nikemycin Fluoxastrobin wetting powder.
Embodiment 3:80% Nikemycin Fluoxastrobin suspending agent
Ingredient names percentage by weight
Nikemycin (active ingredient) 10%
Fluoxastrobin (active ingredient) 70%
Naphthalenesulfonic acid-formaldehyde condensate (dispersant) 8%
Dodecyl sodium sulfate (wetting agent) 3%
Xanthans (thickener) 2%
Glycerine (antifreeze) 5%
Polyoxyethylene polyoxypropylene glycerin ether (defoamer) 2%
Water complements to 100%
The ratio of each components such as active component, dispersant, wetting agent, thickener, antifreeze, defoamer and water in formula mixed, it is broken to add sand mill medium sand abrasive dust, then drops in homogeneous still and obtain 80% Nikemycin Fluoxastrobin suspending agent after mixing.
Embodiment 4:12% Nikemycin azoxystrobin water dispersible granule
Ingredient names percentage by weight
Nikemycin (active ingredient) 4%
Fluoxastrobin (active ingredient) 8%
Lauryl sodium sulfate (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 6%
Ammonium sulfate (disintegrant) 5%
Starch (binding agent) 2%
Precipitated calcium carbonate (filler) complements to 100%
Active ingredient, auxiliary agent and the filler ratio in formula is mixed, becomes wetting powder through air-flow crushing, then add a certain amount of water mixing extruder grain, after drying screening, obtain 12% Nikemycin azoxystrobin water dispersible granule.
Embodiment 5:22% Nikemycin Fluoxastrobin wetting powder
Ingredient names percentage by weight
Nikemycin (active ingredient) 2%
Fluoxastrobin (active ingredient) 20%
Lauryl sodium sulfate (wetting agent) 3%
Sodium lignin sulfonate (dispersant) 5%
White Carbon black (filler) 9%
Kaolin (filler) complements to 100%
The ratio in formula such as active ingredient, auxiliary agent and filler is fully mixed, mixes again after air-flow crushing and obtain 22% Nikemycin Fluoxastrobin wetting powder.
Embodiment 6:41% Nikemycin azoxystrobin water dispersible granule
Ingredient names percentage by weight
Nikemycin (active ingredient) 1%
Fluoxastrobin (active ingredient) 40%
Lauryl sodium sulfate (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 6%
Ammonium sulfate (disintegrant) 5%
Starch (binding agent) 2%
Precipitated calcium carbonate (filler) complements to 100%
Active ingredient, auxiliary agent and the filler ratio in formula is mixed, becomes wetting powder through air-flow crushing, then add a certain amount of water mixing extruder grain, after drying screening, obtain 41% Nikemycin azoxystrobin water dispersible granule.
Select above embodiment to carry out preventing and treating the field control effectiveness test of cladosporium leaf and fruit mould of tomato, by the Contrast on effect with single dose antibiotic in pyrimidine nucleoside class and Ningnanmycin, verify composite after synergistic effect.
field efficacy embodiment: Nikemycin and Fluoxastrobin series complex preparation prevent and treat cladosporium leaf and fruit mould of tomato field control effectiveness test.
Test method: be experimental field located in tomato booth field, emerging town, Pucheng County, Shaanxi Province, after tomato seedling morbidity, carries out spraying process, to spray clear water for blank with each medicament respectively.Each process repetition 3 times, once, continuous 2 times, second time dispenser 7 days " Invest, Then Investigate " state of an illness, record severity in units of blade in dispenser in each 7 days.Calculate disease index and control efficiency.The grade scale of disease is: 0 grade: blade is without scab; 1 grade: lesion area accounts for less than 10% of blade area; 2 grades: lesion area accounts for the 10-30% of blade area; 3 grades: lesion area accounts for the 30-50% of blade area; 4 grades: lesion area accounts for more than 50% of blade area to fallen leaves.
Result of the test: the field control effectiveness test that above-mentioned formulation Example prevents and treats cladosporium leaf and fruit mould of tomato the results are shown in Table 2
As can be seen from Table 2, the preventive effect of bactericidal composition of the present invention to cladosporium leaf and fruit mould of tomato contrasts apparently higher than single dose, and minimum is 85.58%, is up to 94.35%.Particularly Nikemycin and Fluoxastrobin proportioning are at 1:10-1:1, and preventive effect is more remarkable, and reach more than 90%, visible Nikemycin and azoxystrobin compound have synergistic effect.
dosage and drug cost embodiment
Table 3 dosage and drug cost
As can be seen from Table 3, Nikemycin and azoxystrobin compound use and can reduce dosage, thus reduce costs, and alleviate the pollution to environment.
Although by referring to the preferred embodiments of the present invention, invention has been described, but those of ordinary skill in the art should be appreciated that and can make various change to it in the form and details, and do not depart from the spirit and scope of the present invention that appended claims limits.
Claims (9)
1. one kind contains the bactericidal composition of Nikemycin and Fluoxastrobin, its active component is Nikemycin and Fluoxastrobin, wherein Nikemycin and Fluoxastrobin weight ratio are 1:40-5:1, and the gross weight percentage composition of two kinds of active components is 2-80%, and all the other are allow in agricultural chemicals to use and acceptable composition.
2. bactericidal composition according to claim 1, is characterized in that, makes the wetting powder of applicable agricultural use, aqua or water dispersible granules.
3. bactericidal composition according to claim 1, is characterized in that, described bactericidal composition also comprises auxiliary agent, and described auxiliary agent comprises emulsifier, dispersant, wetting agent, disintegrant, binding agent.
4. bactericidal composition according to claim 1, is characterized in that, the weight ratio of described active component Nikemycin and Fluoxastrobin is 1:10-1:1.
5. bactericidal composition according to claim 4, is characterized in that, the weight ratio of described active component Nikemycin and Fluoxastrobin is 1:2.
6. bactericidal composition according to claim 1, is characterized in that, in described bactericidal composition, the gross weight percentage composition of active component is 2-60%; Be more preferably 12%.
7. bactericidal composition according to claim 1, is characterized in that, in described bactericidal composition, the gross weight percentage composition of active component is 12%.
8. the application of the microbicide compositions any one of claim 1-7 described in claim in control Cereal, each planting fruit-trees, vegetable crop disease.
9. bactericidal composition according to claim 8, is characterized in that, described disease comprises wheat powdery mildew, rice blast, Glomerella cingulata, cladosporium leaf and fruit mould of tomato, powdery mildew of strawberry, gray mold of cucumber.
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104886155A (en) * | 2015-05-27 | 2015-09-09 | 邓全芳 | Fungicidal composition containingpyrimethanil and nikkomycins and preparation thereof |
| CN105028484A (en) * | 2015-05-27 | 2015-11-11 | 邓全芳 | Sterilization composition containing metalaxyl-hymexazol and nikkomycin, and preparation thereof |
| CN106259462A (en) * | 2015-05-11 | 2017-01-04 | 牡丹江佰佳信生物科技有限公司 | A kind of bactericidal composition and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN102067851B (en) * | 2011-01-20 | 2014-03-05 | 陕西美邦农药有限公司 | Antibacterial composition containing polyoxin and methoxyacrylate compound |
| CN102239862A (en) * | 2011-05-27 | 2011-11-16 | 江苏省绿盾植保农药实验有限公司 | Compound bactericide of azoxystrobin and polyoxin |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106259462A (en) * | 2015-05-11 | 2017-01-04 | 牡丹江佰佳信生物科技有限公司 | A kind of bactericidal composition and application thereof |
| CN106259462B (en) * | 2015-05-11 | 2019-06-07 | 牡丹江佰佳信生物科技有限公司 | A kind of bactericidal composition and its application |
| CN104886155A (en) * | 2015-05-27 | 2015-09-09 | 邓全芳 | Fungicidal composition containingpyrimethanil and nikkomycins and preparation thereof |
| CN105028484A (en) * | 2015-05-27 | 2015-11-11 | 邓全芳 | Sterilization composition containing metalaxyl-hymexazol and nikkomycin, and preparation thereof |
| CN104886155B (en) * | 2015-05-27 | 2017-11-07 | 邓全芳 | The bactericidal composition and its preparation of a kind of pyrimethanil-contain bactericide and Nikemycin |
| CN105028484B (en) * | 2015-05-27 | 2017-12-05 | 邓全芳 | The bactericidal composition and its preparation of a kind of hymexazol of frost containing first and Nikemycin |
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