CN1043406C - Method for preparation of compound Qingdaisan powder - Google Patents
Method for preparation of compound Qingdaisan powder Download PDFInfo
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- CN1043406C CN1043406C CN93121590A CN93121590A CN1043406C CN 1043406 C CN1043406 C CN 1043406C CN 93121590 A CN93121590 A CN 93121590A CN 93121590 A CN93121590 A CN 93121590A CN 1043406 C CN1043406 C CN 1043406C
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- qingdaisan
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- thick paste
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- 239000000843 powder Substances 0.000 title claims abstract description 25
- 239000010075 Qingdai compound Substances 0.000 title claims abstract description 10
- 150000001875 compounds Chemical class 0.000 title claims abstract description 10
- 238000000034 method Methods 0.000 title claims abstract description 9
- 238000002360 preparation method Methods 0.000 title claims description 6
- 239000003814 drug Substances 0.000 claims abstract description 15
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims abstract description 7
- 244000080767 Areca catechu Species 0.000 claims abstract description 7
- 235000006226 Areca catechu Nutrition 0.000 claims abstract description 7
- 229910052957 realgar Inorganic materials 0.000 claims abstract description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 14
- 239000000706 filtrate Substances 0.000 claims description 14
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 13
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 8
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
- 238000001035 drying Methods 0.000 claims description 6
- 239000000203 mixture Substances 0.000 claims description 6
- 230000001954 sterilising effect Effects 0.000 claims description 6
- 238000004659 sterilization and disinfection Methods 0.000 claims description 6
- 238000000605 extraction Methods 0.000 claims description 5
- 238000010438 heat treatment Methods 0.000 claims description 5
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 claims description 4
- 238000013467 fragmentation Methods 0.000 claims description 4
- 238000006062 fragmentation reaction Methods 0.000 claims description 4
- 238000001802 infusion Methods 0.000 claims description 4
- 238000002386 leaching Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 239000006228 supernatant Substances 0.000 claims description 4
- 229910000019 calcium carbonate Inorganic materials 0.000 claims description 3
- 238000004821 distillation Methods 0.000 claims description 3
- 239000000796 flavoring agent Substances 0.000 claims description 3
- 235000019634 flavors Nutrition 0.000 claims description 3
- 238000002156 mixing Methods 0.000 claims description 3
- 230000001476 alcoholic effect Effects 0.000 claims description 2
- 235000011194 food seasoning agent Nutrition 0.000 claims description 2
- 238000004108 freeze drying Methods 0.000 claims description 2
- 238000005325 percolation Methods 0.000 claims description 2
- -1 filter Substances 0.000 claims 1
- 239000002994 raw material Substances 0.000 claims 1
- 210000003679 cervix uteri Anatomy 0.000 abstract description 7
- 230000000694 effects Effects 0.000 abstract description 7
- 201000010099 disease Diseases 0.000 abstract description 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 5
- 239000000546 pharmaceutical excipient Substances 0.000 abstract description 4
- 229940079593 drug Drugs 0.000 abstract description 3
- 239000007921 spray Substances 0.000 abstract description 3
- 229930013930 alkaloid Natural products 0.000 abstract 2
- MFYSUUPKMDJYPF-UHFFFAOYSA-N 2-[(4-methyl-2-nitrophenyl)diazenyl]-3-oxo-n-phenylbutanamide Chemical compound C=1C=CC=CC=1NC(=O)C(C(=O)C)N=NC1=CC=C(C)C=C1[N+]([O-])=O MFYSUUPKMDJYPF-UHFFFAOYSA-N 0.000 abstract 1
- 241000212948 Cnidium Species 0.000 abstract 1
- 241000099774 Cuscuta salina Species 0.000 abstract 1
- 241000218682 Pseudolarix amabilis Species 0.000 abstract 1
- 241000219784 Sophora Species 0.000 abstract 1
- 206010046914 Vaginal infection Diseases 0.000 abstract 1
- 201000008100 Vaginitis Diseases 0.000 abstract 1
- 229940037003 alum Drugs 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 230000002349 favourable effect Effects 0.000 abstract 1
- 241000411851 herbal medicine Species 0.000 abstract 1
- 210000003739 neck Anatomy 0.000 abstract 1
- 208000006374 Uterine Cervicitis Diseases 0.000 description 5
- 206010008323 cervicitis Diseases 0.000 description 5
- 230000001225 therapeutic effect Effects 0.000 description 5
- 210000001215 vagina Anatomy 0.000 description 5
- 235000008216 herbs Nutrition 0.000 description 4
- 238000001914 filtration Methods 0.000 description 3
- 206010061218 Inflammation Diseases 0.000 description 2
- 208000003251 Pruritus Diseases 0.000 description 2
- 238000005469 granulation Methods 0.000 description 2
- 230000003179 granulation Effects 0.000 description 2
- 230000002757 inflammatory effect Effects 0.000 description 2
- 230000001338 necrotic effect Effects 0.000 description 2
- 230000001737 promoting effect Effects 0.000 description 2
- 239000002253 acid Substances 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000002552 dosage form Substances 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000007803 itching Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 244000045947 parasite Species 0.000 description 1
- 230000000590 parasiticidal effect Effects 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 238000007873 sieving Methods 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 210000003905 vulva Anatomy 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
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- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to compound qingdaisan which is prepared from nine Chinese herbal medicines, wherein alkaloids with effective curative effects of common cnidium fruit, golden thread, lightyellow sophora root, golden larch bark and folium syringae are extracted by different methods. After being crushed and sieved, calcined alum, catechu, realgar and bear gall are mixed with the alkaloids, sieved, dried, sterilized and packed in a separate way; then, the compound qingdaisan is prepared. The compound qingdaisan is used for treating various kinds of vaginitis and trachelitis of females; the females with diseases need adopting a drug powder applying device for cervixes offered in the China patent with the patent number of 92200616.4 to spray the medicine powder on uterine necks and in vaginae. Excipients do not need adding to the medicine, so the medicine of the present invention is favorable for realizing the curative effects.
Description
The present invention is a kind of preparation method of Chinese herb medicine, is the process for preparing medicine that is used for the treatment of female vagina and cervicitis.
At present, the medicine of treatment female vagina and cervicitis mainly contains two classes, and a class is that medicine is made suppository, and another kind of is that medicine is made tablet, is used to the intravaginal filling by patient.This two classes pharmaceutical dosage form all needs to add excipient, and the therapeutic component that these excipient influence in the medicine directly contacts with the inflammation wound surface, thereby has reduced the curative effect of therapeutic component, and easily pollutes underwear again.
The present invention designs for the effect that improves treatment female vagina and cervicitis.
According to tcm theory, female vagina and cervicitis are referred to as " leukorrheal diseases ", and the traditional Chinese medical science is thought: " leukorrheal diseases " main diseases is because of being: " invade in the damp, accumulate and give birth to heat.Chinese medicine to the Therapeutic Principle of " leukorrheal diseases " is: based on damp eliminating, and the suitable heat-clearing and toxic substances removing of holding concurrently.To have cervix uteri to waste mashed more in view of patient, the vulva pruritus symptom, and clinical experience proves, adds Chinese medicinal herbs with removing the necrotic tissue and promoting granulation, the Chinese crude drug of holding back wound and killing parasites for relieving itching, can strengthen therapeutic effect.
The technology of the present invention solution:
The present invention is made up of following Chinese medicinal herbs: Fructus Cnidii, Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Folium Caryophylli, dry Alumen, CATECHU, Realgar, Fel Ursi.
The present invention prepares as follows:
The first step: Fructus Cnidii and Folium Caryophylli adopt water to do the leaching solvent respectively, adopt infusion process, and decocting method or percolation will be condensed into thick paste (1) after the leachate filtration.Rhizoma Coptidis and Radix Sophorae Flavescentis adopt water to add the acid adjuvant that leaches respectively and do the leaching solvent, heating extraction, and extracting liquid filtering, adding alkali adjustment filtrate pH value such as calcium carbonate or sodium hydroxide is 7, leaves standstill a few hours, is condensed into thick paste (2) and (3) after filtering once more.Cortex Pseudolaricis as leaching solvent, adopts infusion process or hot infusion process with 40-80% ethanol, and after leachate filtered, the ethanol with in the way of distillation recovery filtrate was condensed into leachate thick paste (4) again.
Second step: after above-mentioned thick paste (1), (2), (3), (4) mixing, can adopt hypobaric drying method, medicated powder A is pulverized, is screened into to thermal vapor stream seasoning or freeze-drying drying.Dry Alumen, CATECHU and Realgar mix the back pulverizes, and is screened into medicated powder B.Fel Ursi is ground into fine powder, and the back of sieving becomes medicated powder C.
The 3rd step:, adopt eo sterilization method, far infrared sterilization or Co with medicated powder A, B, the mutual mix homogeneously of C
60The radiation sterilization sterilization all can.
Ill women can adopt China's No. 92200616.4 patents---drug powder applying device for cervix, directly sprays on the cervix uteri compound Qingdaisan powder and intravaginal, also can spray on the cervix uteri compound Qingdaisan powder and intravaginal by other people.
Adopt the present invention to treat female vagina and cervicitis is obtained following good effect: not add on the compound Qingdaisan powder of any excipient on cervix uteri and after on the intravaginal inflammatory wound surface, can contact with whole inflammatory wound surface immediately, can bring into play the anti-inflammation of medicine rapidly fully, promote the effect of planing surface healing.Nine flavor Chinese medicinal herbs pharmacological action complementations have increased antibacterial range, have strengthened antibiotic parasiticidal effect, have removing the necrotic tissue and promoting granulation again, hold back the effect of wound, have improved the scorching and various colpitic therapeutic effect of woman cervix uteri significantly.
The embodiment of the invention:
One, take off and state Chinese medicinal herbs, can prepare by following proportioning:
Fructus Cnidii 200kg Rhizoma Coptidis 150kg Radix Sophorae Flavescentis 200kg Cortex Pseudolaricis 100kg
Folium Caryophylli 100kg dry Alumen 10kg CATECHU 8kg Realgar 6kg
Fel Ursi 2kg
Two, compound Qingdaisan powder preparation method:
The first step: Fructus Cnidii and Folium Caryophylli add water 8-10 doubly, decoct twice, decoct 40-10 minute at every turn, and gradation filters, merging filtrate, and filtrate is concentrated into relative density and is: the thick paste of 1.20-1.25 (1).Add 8-10 after the Radix Sophorae Flavescentis fragmentation and doubly measure 0.2% sulfuric acid solution, heating extraction twice, each about 1 hour, merging filtrate was 7 with 10% sodium hydroxide solution adjust pH, left standstill 2 hours, filtered, filtrate is concentrated into the thick paste that relative density is 1.20-1.25 (2).Add the 0.1 % citric acid soln that 8-10 doubly measures after the Rhizoma Coptidis fragmentation, heating extraction twice, each about 1 hour, merging filtrate, using calcium carbonate or sodium hydroxid adjustment pH value is 7, leaves standstill 2 hours, filter, it is 1.12-1.22 thick paste (3) that filtrate is concentrated into relative density.Add 5 times of amount 75% alcoholic solution after the Cortex Pseudolaricis shredding, put in 40 ℃ of hot water lixiviate 48 hours, incline and get supernatant, residue adds doubly 75% ethanol of 1-2 again, put in 40 ℃ of hot water lixiviate 48 hours, and filtered, filtrate and the merging of above-mentioned supernatant, reclaim ethanol to there not being the alcohol flavor with the way of distillation, be condensed into the thick paste that relative density is 1.20-1.25 (4).
Second step: after above-mentioned thick paste (1), (2), (3), (4) mixing, adopt the hypobaric drying method drying, pulverize, cross 100 mesh sieves, become medicated powder A.Dry Alumen, CATECHU and Realgar mix the back pulverizes, and crosses 100 mesh sieves, becomes medicated powder B.Fel Ursi is ground into fine powder, crosses 100 mesh sieves, becomes medicated powder C.
The 3rd step: with medicated powder A, B, the mutual mix homogeneously of C, put in 80 ℃ of far infrared casees, dry sterilization 2 hours is crossed 100 mesh sieves, and is aseptic subpackaged by each consumption 0.6g～1.0g, and sealing promptly.
Claims (1)
1. the preparation method of a compound Qingdaisan powder is characterized in that:
Form by the following raw materials according medicine: Fructus Cnidii 200kg, Rhizoma Coptidis 150kg, Radix Sophorae Flavescentis 200kg, Cortex Pseudolaricis 100kg, Folium Caryophylli 100kg, dry Alumen 10kg, CATECHU 8kg, Realgar 6kg, Fel Ursi 2kg;
Preparation as follows:
The first step: Fructus Cnidii and Folium Caryophylli adopt water to do the leaching solvent respectively, adopt infusion process, and decocting method or percolation after leachate filtered, are concentrated into relative density and are: the thick paste 1 of 1.20-1.25; Add 8-10 after the Radix Sophorae Flavescentis fragmentation and doubly measure 0.2% sulfuric acid solution, heating extraction twice, each about 1 hour, merging filtrate, transferring pH value with 10% sodium hydroxide solution is 7, leaves standstill 2 hours, filters, filtrate is concentrated into the thick paste 2 that relative density is 1.20-1.25; Add the 0.1% citric acid solution that 8-10 doubly measures after the Rhizoma Coptidis fragmentation, heating extraction twice, each about 1 hour, merging filtrate, using calcium carbonate or sodium hydroxide adjustment pH value is 7, leaves standstill 2 hours, filter, filtrate is concentrated into relative density and is: the thick paste 3 of 1.12-1.22; 75% alcoholic solution that adds 5 times of amounts after the Cortex Pseudolaricis shredding, put lixiviate 48 hours in the 40 degree hot water, incline and get supernatant, residue adds doubly 75% ethanol of 1-2 again, put lixiviate 48 hours in the 40 degree hot water, filter, filtrate and the merging of above-mentioned supernatant, reclaim ethanol to there not being the alcohol flavor with the way of distillation, being condensed into relative density is the thick paste 4 of 1.20-1.25;
Second step: after above-mentioned thick paste 1,2,3,4 mixing, adopt hypobaric drying method, thermal vapor stream seasoning or freeze-drying drying are pulverized, and cross 100 mesh sieves, become medicated powder A; Dry Alumen, CATECHU and Realgar mix the back pulverizes, and crosses 100 mesh sieves, becomes medicated powder B; Fel Ursi is ground into fine powder, crosses 100 mesh sieves, becomes medicated powder C;
The 3rd step: with medicated powder A, B, the mutual mix homogeneously of C, put in 80 ℃ of far infrared casees, dry sterilization 2 hours is crossed 100 mesh sieves promptly.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93121590A CN1043406C (en) | 1993-12-27 | 1993-12-27 | Method for preparation of compound Qingdaisan powder |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN93121590A CN1043406C (en) | 1993-12-27 | 1993-12-27 | Method for preparation of compound Qingdaisan powder |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1094964A CN1094964A (en) | 1994-11-16 |
| CN1043406C true CN1043406C (en) | 1999-05-19 |
Family
ID=4993748
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN93121590A Expired - Fee Related CN1043406C (en) | 1993-12-27 | 1993-12-27 | Method for preparation of compound Qingdaisan powder |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1043406C (en) |
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004075844A3 (en) * | 2003-02-26 | 2005-07-07 | Unigen Pharmaceuticals Inc | Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions |
| WO2005020932A3 (en) * | 2003-09-02 | 2005-07-28 | Unigen Pharmaceuticals Inc | Formulation of a mixture of free-b-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
| US7514469B2 (en) | 2002-04-30 | 2009-04-07 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent |
| US7695743B2 (en) | 2002-04-30 | 2010-04-13 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of Free-B-Ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| US8790724B2 (en) | 2003-04-04 | 2014-07-29 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
| US8945518B2 (en) | 2002-04-30 | 2015-02-03 | Unigen, Inc. | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115282194A (en) * | 2022-07-28 | 2022-11-04 | 陕西康惠制药股份有限公司 | Preparation method of traditional Chinese medicine composition for clearing heat, removing dampness, killing parasites and relieving itching |
-
1993
- 1993-12-27 CN CN93121590A patent/CN1043406C/en not_active Expired - Fee Related
Non-Patent Citations (3)
| Title |
|---|
| 《云南中医杂志》1982,3(5) 1982. 5.30 滴虫外洗方 * |
| 《云南中医杂志》1982,3(5) 1982. 5.30 滴虫外洗方;《云南中医杂志》1982,3(5) 1982. 5.30 霉菌外洗方 * |
| 《云南中医杂志》1982,3(5) 1982. 5.30 霉菌外洗方 * |
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| US8124134B2 (en) | 2002-03-22 | 2012-02-28 | Unigen, Inc. | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from Acacia |
| US9168242B2 (en) | 2002-03-22 | 2015-10-27 | Unigen, Inc. | Isolation of a dual COX-2 and 5-lipdxygenase inhibitor from Acacia |
| US8568799B2 (en) | 2002-03-22 | 2013-10-29 | Unigen, Inc. | Isolation of a dual COX-2 and 5-lipoxygenase inhibitor from acacia |
| US7108868B2 (en) | 2002-03-22 | 2006-09-19 | Unigen Pharmaceuticals, Inc. | Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia |
| US8034387B2 (en) | 2002-04-30 | 2011-10-11 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| US8945518B2 (en) | 2002-04-30 | 2015-02-03 | Unigen, Inc. | Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions |
| US7695743B2 (en) | 2002-04-30 | 2010-04-13 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of Free-B-Ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| US9849152B2 (en) | 2002-04-30 | 2017-12-26 | Unigen, Inc. | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent |
| US9655940B2 (en) | 2002-04-30 | 2017-05-23 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
| US7514469B2 (en) | 2002-04-30 | 2009-04-07 | Unigen Pharmaceuticals, Inc. | Formulation of a mixture of Free-B-ring flavonoids and flavans as a therapeutic agent |
| US9370544B2 (en) | 2002-04-30 | 2016-06-21 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent |
| US8652535B2 (en) | 2002-04-30 | 2014-02-18 | Unigen, Inc. | Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| WO2004075844A3 (en) * | 2003-02-26 | 2005-07-07 | Unigen Pharmaceuticals Inc | Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions |
| JP2006519231A (en) * | 2003-02-26 | 2006-08-24 | ユニゲン・ファーマシューティカルス・インコーポレーテッド | Formulations for the prevention and treatment of carbohydrate-induced diseases and conditions |
| US7531521B2 (en) | 2003-02-26 | 2009-05-12 | Unigen Pharmaceuticals, Inc. | Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions |
| US8790724B2 (en) | 2003-04-04 | 2014-07-29 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
| US9622964B2 (en) | 2003-04-04 | 2017-04-18 | Unigen, Inc. | Formulation of dual cycloxygenase (COX) and lipoxygenase (LOX) inhibitors for mammal skin care |
| WO2005020932A3 (en) * | 2003-09-02 | 2005-07-28 | Unigen Pharmaceuticals Inc | Formulation of a mixture of free-b-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments |
| RU2392957C2 (en) * | 2003-09-02 | 2010-06-27 | Юниджен Фармасьютиклз, Инк. | Composition containing mixed free-ring flavonoids and flavanov used for prevention and treatment of impaired cognition and age-specific amnesia |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1094964A (en) | 1994-11-16 |
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