CN104336080B - A kind of containing antibiotic in pyrimidine nucleoside class and the bactericidal composition of hymexazol and application - Google Patents
A kind of containing antibiotic in pyrimidine nucleoside class and the bactericidal composition of hymexazol and application Download PDFInfo
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- CN104336080B CN104336080B CN201410595728.3A CN201410595728A CN104336080B CN 104336080 B CN104336080 B CN 104336080B CN 201410595728 A CN201410595728 A CN 201410595728A CN 104336080 B CN104336080 B CN 104336080B
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- Prior art keywords
- hymexazol
- bactericidal composition
- antibiotic
- pyrimidine nucleoside
- nucleoside class
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- 239000005794 Hymexazol Substances 0.000 title claims abstract description 45
- 230000003115 biocidal effect Effects 0.000 title claims abstract description 43
- 239000002718 pyrimidine nucleoside Substances 0.000 title claims abstract description 43
- 239000000203 mixture Substances 0.000 title claims abstract description 41
- KGVPNLBXJKTABS-UHFFFAOYSA-N hymexazol Chemical group CC1=CC(O)=NO1 KGVPNLBXJKTABS-UHFFFAOYSA-N 0.000 title claims abstract description 40
- 230000000844 anti-bacterial effect Effects 0.000 title claims abstract description 26
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 15
- 239000003795 chemical substances by application Substances 0.000 claims description 10
- 238000002360 preparation method Methods 0.000 claims description 10
- 239000002270 dispersing agent Substances 0.000 claims description 8
- 239000004563 wettable powder Substances 0.000 claims description 8
- 239000000080 wetting agent Substances 0.000 claims description 8
- -1 pyrimidine core Glycoside Chemical class 0.000 claims description 7
- 239000012752 auxiliary agent Substances 0.000 claims description 6
- 239000003995 emulsifying agent Substances 0.000 claims description 6
- 239000004562 water dispersible granule Substances 0.000 claims description 6
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 239000011230 binding agent Substances 0.000 claims description 4
- 239000002552 dosage form Substances 0.000 claims description 2
- 229930182470 glycoside Natural products 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 abstract description 9
- 244000052616 bacterial pathogen Species 0.000 abstract description 4
- 230000003111 delayed effect Effects 0.000 abstract 1
- 239000004615 ingredient Substances 0.000 description 18
- 239000003814 drug Substances 0.000 description 17
- 241000219109 Citrullus Species 0.000 description 10
- 235000012828 Citrullus lanatus var citroides Nutrition 0.000 description 10
- 244000270200 Citrullus vulgaris Species 0.000 description 10
- 235000012840 Citrullus vulgaris Nutrition 0.000 description 10
- 239000000945 filler Substances 0.000 description 10
- 230000001988 toxicity Effects 0.000 description 9
- 231100000419 toxicity Toxicity 0.000 description 9
- 201000010099 disease Diseases 0.000 description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000002156 mixing Methods 0.000 description 6
- 238000012360 testing method Methods 0.000 description 6
- 238000000034 method Methods 0.000 description 5
- 239000000575 pesticide Substances 0.000 description 5
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 241000223221 Fusarium oxysporum Species 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- 239000004141 Sodium laurylsulphate Substances 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- YDEXUEFDPVHGHE-GGMCWBHBSA-L disodium;(2r)-3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Na+].[Na+].COC1=CC=CC(C[C@H](CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O YDEXUEFDPVHGHE-GGMCWBHBSA-L 0.000 description 4
- 239000002777 nucleoside Substances 0.000 description 4
- 125000003835 nucleoside group Chemical group 0.000 description 4
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 4
- 239000002689 soil Substances 0.000 description 4
- AMNAZJFEONUVTD-KEWDHRJRSA-N (2s,3s,4s,5r,6r)-6-(4-amino-2-oxopyrimidin-1-yl)-4,5-dihydroxy-3-[[(2s)-3-hydroxy-2-[[2-(methylamino)acetyl]amino]propanoyl]amino]oxane-2-carboxamide Chemical compound O1[C@H](C(N)=O)[C@@H](NC(=O)[C@H](CO)NC(=O)CNC)[C@H](O)[C@@H](O)[C@@H]1N1C(=O)N=C(N)C=C1 AMNAZJFEONUVTD-KEWDHRJRSA-N 0.000 description 2
- CYEJMVLDXAUOPN-UHFFFAOYSA-N 2-dodecylphenol Chemical compound CCCCCCCCCCCCC1=CC=CC=C1O CYEJMVLDXAUOPN-UHFFFAOYSA-N 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- FEACDOXQOYCHKU-UHFFFAOYSA-N Gougerotin Natural products CNCC(=O)NC1=NC(=O)N(C=C1)C2OC(C(O)C(NC(=O)C(N)CO)C2O)C(=O)N FEACDOXQOYCHKU-UHFFFAOYSA-N 0.000 description 2
- 208000031888 Mycoses Diseases 0.000 description 2
- 241000918585 Pythium aphanidermatum Species 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 235000012211 aluminium silicate Nutrition 0.000 description 2
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 2
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 2
- 235000011130 ammonium sulphate Nutrition 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 239000006229 carbon black Substances 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 239000000306 component Substances 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 244000053095 fungal pathogen Species 0.000 description 2
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 244000052769 pathogen Species 0.000 description 2
- 230000001717 pathogenic effect Effects 0.000 description 2
- 239000008194 pharmaceutical composition Substances 0.000 description 2
- 229940088417 precipitated calcium carbonate Drugs 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000001018 virulence Effects 0.000 description 2
- 241001530056 Athelia rolfsii Species 0.000 description 1
- 241000193738 Bacillus anthracis Species 0.000 description 1
- 206010008570 Chloasma Diseases 0.000 description 1
- 244000241257 Cucumis melo Species 0.000 description 1
- 235000015510 Cucumis melo subsp melo Nutrition 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000221785 Erysiphales Species 0.000 description 1
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 1
- 208000003351 Melanosis Diseases 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- 241000082085 Verticillium <Phyllachorales> Species 0.000 description 1
- FJJCIZWZNKZHII-UHFFFAOYSA-N [4,6-bis(cyanoamino)-1,3,5-triazin-2-yl]cyanamide Chemical compound N#CNC1=NC(NC#N)=NC(NC#N)=N1 FJJCIZWZNKZHII-UHFFFAOYSA-N 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 238000004166 bioassay Methods 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
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- 230000009977 dual effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000004345 fruit ripening Effects 0.000 description 1
- 230000002070 germicidal effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 230000003641 microbiacidal effect Effects 0.000 description 1
- 230000000813 microbial effect Effects 0.000 description 1
- 229940124561 microbicide Drugs 0.000 description 1
- 239000002855 microbicide agent Substances 0.000 description 1
- 238000009335 monocropping Methods 0.000 description 1
- 150000002916 oxazoles Chemical class 0.000 description 1
- 235000010603 pastilles Nutrition 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 238000012827 research and development Methods 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
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- 241000894007 species Species 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
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Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The present invention relates to a kind of containing antibiotic in pyrimidine nucleoside class with the bactericidal composition of hymexazol, wherein, active component is antibiotic in pyrimidine nucleoside class and hymexazol, and antibiotic in pyrimidine nucleoside class and hymexazol weight ratio are 32:3 1:48.The bactericidal composition preventive effect of the present invention is good, low cost, pathogenic bacteria resistance can be delayed to produce.
Description
Technical field
The invention belongs to technical field of pesticide, be specifically related to a kind of sterilization group containing antibiotic in pyrimidine nucleoside class and hymexazol
Compound and application thereof.
Background technology
Antibiotic in pyrimidine nucleoside class, also known as pesticide corrosion 120, is made up of S.hygrospinous var.Beijingensis fermented extracted, belongs to
In broad-spectrum germicide, there is protection and treatment dual function.This medicine has obvious inhibitory action to mycelial growth, makes mycelia
Growth deformation, internal protoplasm solidification, hinders the synthesis of pathogen protein, causes pathogenic bacteria dead.It can prevent and treat fruit tree, vegetables
The multiple fungal diseases such as powdery mildew on dish, cereal crops, anthrax, epidemic disease, melasma.
Hymexazol belongs to oxazole series bactericidal agent, has interior absorption and conductivity.After this medicine entrance soil by soil absorption also
Mycelial normally with sprouting and the pathogenic fungi of the inorganic metal salt ions binding such as the ferrum in soil, aluminum, effectively suppression spore
Grow or directly kill pathogenic bacteria.It is true to multiple cause of diseases such as droop, damping-off, verticillium wilt, damping off, banded sclerotial blight, seedling rots
Microbial plant disease has preventive effect.
Watermelon blight is one of Major Diseases of Citrullus vulgaris, and it is a kind of soil caused by Fusarium oxysporum Citrullus vulgaris transformant
Fax fungal disease.Expanding rapidly due to cultivating watermelon area in recent years, continuous cropping Citrullus vulgaris area increases, and what the performance of this disease increased the weight of becomes
Gesture.But, it is possible to the effectively medicament of preventing and treating watermelon blight is less, produces needs for satisfied actual Citrullus vulgaris, and the present invention is with Citrullus vulgaris
Droop is controlling object, to part pesticide species resource, has carried out lot of experiments, finds antibiotic in pyrimidine nucleoside class and dislikes mould
Spirit is compounding has significant preventive effect to watermelon blight.
Summary of the invention
It is an object of the invention to provide that a kind of preventive effect is good, low cost, the pathogenic bacteria resistance that can delay produce containing pyridimine nucleosides
Bactericidal composition of antibiotics and hymexazol and application thereof.
It is an object of the invention to be achieved through the following technical solutions:
A kind of containing antibiotic in pyrimidine nucleoside class with the bactericidal composition of hymexazol, wherein, active component is pyridimine nucleosides
Antibiotics and hymexazol, antibiotic in pyrimidine nucleoside class and hymexazol weight ratio are 32:3-1:48, and remaining is to permit in bactericidal composition
Permitted to use and acceptable composition.
Preferably, above-mentioned antibiotic in pyrimidine nucleoside class and hymexazol weight ratio are 2:3-1:24；More preferably 1:6.
Preferably, in above-mentioned bactericidal composition, the weight percentage of two kinds of active components is 2-70%；More preferably 70%.
Preferably, above-mentioned bactericidal composition also comprises auxiliary agent, and described auxiliary agent is selected from emulsifying agent, dispersant, wetting agent, disintegrate
One or more in agent, binding agent.
The composition pesticide of the present invention can make the dosage forms such as wettable powder, water preparation, water dispersible granules.
Microbicide compositions of the present invention can be applicable to the west that preventing and treating is caused by Fusarium oxysporum Citrullus vulgaris transformant pathogenic fungi
Cucurbit wilt.
The bactericidal composition of the present invention can be prepared by the conventional method of prior art, compared to prior art,
There is following beneficial effect:
1, the bactericidal composition of the present invention can effectively prevent and treat watermelon blight, and preventive effect is better than single dose comparison, shows notable
Potentiation.
2, two kinds of active component in the bactericidal composition of the present invention compound, and synergism is notable, to Fusarium oxysporum west
Melon transformant may act on multiple site, makes pathogen be not likely to produce Drug resistance, and technique effect improves notable.
3, the bactericidal composition of the present invention can reduce dosage, reduces use cost.
Detailed description of the invention
In order to make the purpose of the present invention, technical scheme and beneficial effect clearer, present invention specific examples below
Illustrate, but the present invention is limited to absolutely not these examples.
Indoor bioassay embodiment
Subjects: Fusarium oxysporum Citrullus vulgaris transformant
Test method: use growth rate method.The pastille flat board of preparation variable concentrations gradient, is measured by inhibition zone method
The reagent agent indoor virulence to withered germ of water-melon mycelial growth.Every kind of process sets 3 repetitions.Calculate the virulence of every kind of medicament
Regression equation, calculates correlation coefficient, releases EC50.
Toxicity index and the co-toxicity coefficient (CTC) of medicament is calculated according to the abundant method of Sun Yun.
Actual measurement toxicity index (ATI)=(standard agent EC50/ reagent agent EC50) × 100
Percentage composition+B medicament toxicity index x the mixture of A in theoretical toxicity index (TTI)=A medicament toxicity index × mixture
The percentage composition of middle B
Co-toxicity coefficient (CTC)=[mixture actual measurement toxicity index (ATI)/mixture theory toxicity index (TTI) × 100
When CTC≤80, then compositions shows as Hangzhoupro short of money effect, and when 80 < CTC < 120, then compositions shows as summation action,
When CTC >=120, then compositions shows as potentiation.
Toxicity Determination result see table 1.
Table 1 antibiotic in pyrimidine nucleoside class Toxicity Determination result to watermelon blight compounding with hymexazol
As can be seen from Table 1, antibiotic in pyrimidine nucleoside class and hymexazol compound with the ratio between 32:3-1:48, and it is altogether
Poison coefficient is all higher than 120, and watermelon blight is had potentiation, and wherein antibiotic in pyrimidine nucleoside class and hymexazol are with 2:3-1:24
Between ratio compound, its co-toxicity coefficient is all higher than 200, and potentiation is the most notable.
Pharmaceutical formulation embodiment
Further illustrate the present invention below by way of pharmaceutical formulation embodiment, but the present invention is only limitted to absolutely not following embodiment.
Embodiment 1 70% antibiotic in pyrimidine nucleoside class hymexazol water preparation
Ingredient names percentage by weight
Antibiotic in pyrimidine nucleoside class (effective ingredient) 10%
Hymexazol (effective ingredient) 60%
Dodecyl phenol polyethenoxy ether (emulsifying agent) 3%
Water complements to 100%
By former for antibiotic in pyrimidine nucleoside class medicine, the former medicine of Ningnanmycin, emulsifying agent, water metering mixing, stir the most prepared
70% antibiotic in pyrimidine nucleoside class hymexazol water preparation of the present composition.
Embodiment 2 2% antibiotic in pyrimidine nucleoside class hymexazol wettable powder
Ingredient names percentage by weight
Antibiotic in pyrimidine nucleoside class (effective ingredient) 1%
Hymexazol (effective ingredient) 1%
Sodium lauryl sulphate (wetting agent) 3%
Sodium lignin sulfonate (dispersant) 5%
White Carbon black (filler) 10%
Kaolin (filler) complements to 100%
Active component, various auxiliary agent and filler etc. are sufficiently mixed in the ratio of formula, after ultra-fine pulverizer disintegrating again
Mixing, obtains 2% antibiotic in pyrimidine nucleoside class hymexazol wettable powder.
Embodiment 3 49% antibiotic in pyrimidine nucleoside class hymexazol water dispersible granules
Ingredient names percentage by weight
Antibiotic in pyrimidine nucleoside class (effective ingredient) 1%
Hymexazol (effective ingredient) 48%
Sodium lauryl sulphate (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 7%
Ammonium sulfate (disintegrating agent) 5%
Starch (binding agent) 2%
Precipitated calcium carbonate (filler) complements to 100%
By active component, dispersant, wetting agent, disintegrating agent and filler in the ratio mix homogeneously of formula, through comminution by gas stream
Become wettable powder, add a certain amount of water mixing extruding and make material, after drying screening, obtain 49% antibiotic in pyrimidine nucleoside class
Hymexazol water dispersible granules.
Embodiment 4 25% antibiotic in pyrimidine nucleoside class hymexazol water preparation
Ingredient names percentage by weight
Antibiotic in pyrimidine nucleoside class (effective ingredient) 1%
Hymexazol (effective ingredient) 24%
Dodecyl phenol polyethenoxy ether (emulsifying agent) 3%
Water complements to 100%
By former for antibiotic in pyrimidine nucleoside class medicine, the former medicine of Ningnanmycin, emulsifying agent, water metering mixing, stir the most prepared
25% antibiotic in pyrimidine nucleoside class hymexazol water preparation of the present composition.
Embodiment 5 10% antibiotic in pyrimidine nucleoside class hymexazol water dispersible granules
Ingredient names percentage by weight
Antibiotic in pyrimidine nucleoside class (effective ingredient) 4%
Hymexazol (effective ingredient) 6%
Sodium lauryl sulphate (wetting agent) 5%
Sodium lignin sulfonate (dispersant) 6%
Ammonium sulfate (disintegrating agent) 5%
Starch (binding agent) 2%
Precipitated calcium carbonate (filler) complements to 100%
By active component, dispersant, wetting agent, disintegrating agent and filler in the ratio mix homogeneously of formula, through comminution by gas stream
Become wettable powder, add a certain amount of water mixing extruding and make material, after drying screening, obtain 10% antibiotic in pyrimidine nucleoside class
Hymexazol water dispersible granules.
Embodiment 6 35% antibiotic in pyrimidine nucleoside class hymexazol wettable powder
Ingredient names percentage by weight
Antibiotic in pyrimidine nucleoside class (effective ingredient) 32%
Hymexazol (effective ingredient) 3%
Sodium lauryl sulphate (wetting agent) 3%
Sodium lignin sulfonate (dispersant) 5%
White Carbon black (filler) 10%
Kaolin (filler) complements to 100%
Active component, various auxiliary agent and filler etc. are sufficiently mixed in the ratio of formula, after ultra-fine pulverizer disintegrating again
Mixing, obtains 35% antibiotic in pyrimidine nucleoside class hymexazol wettable powder.
Field efficacy embodiment
In order to verify the indoor biometrics potentiation that antibiotic in pyrimidine nucleoside class and hymexazol compound, the above-mentioned system of the present invention
Agent prescription embodiment has carried out field control effectiveness test.
This test arrangement is in Long Chi town, Pucheng County, Shaanxi Province, and test medicine is by Ludun Biological Products Co., Ltd., Shaanxi
Research and development, offer, comparison medicament 4% antibiotic in pyrimidine nucleoside class water preparation (commercial), 30% hymexazol water preparation (commercial).
Transplant latter 15 days at Citrullus vulgaris, when 22 days, respectively carry out medicament pouring root, blank filling clear water.Fruit maturation phase investigation Citrullus vulgaris is withered
Disease of the withering state of an illness, calculates preventive effect.Result of the test is as follows:
Table 2 complex preparation different with hymexazol Han antibiotic in pyrimidine nucleoside class is to watermelon blight test of pesticide effectiveness result
From table 2 it can be seen that after antibiotic in pyrimidine nucleoside class and hymexazol compound with the different proportion of the present invention, to transplanting
Rear Citrullus vulgaris is carried out continuously twice pouring root, can effectively prevent and treat watermelon blight, and preventive effect is superior to compare medicament, especially pyridimine nucleosides
Antibiotics and hymexazol are compounding between 2:3-1:24, and preventive effect is more than 86%, and preventive effect is more notable, it is seen that pyridimine nucleosides is antibacterial
Element and hymexazol have good potentiation in the ratio of the present invention is compounding.Bactericidal composition of the present invention under test dose to non-
Target crops and natural enemy have no adverse effects.
Dosage and drug cost embodiment
Table 3 dosage and drug cost
From table 3 it can be seen that antibiotic in pyrimidine nucleoside class and hymexazol compound use can reduce dosage, reduce and use
Cost.
Although by referring to the preferred embodiments of the present invention, invention has been described, but this area is common
It will be appreciated by the skilled person that in the form and details various change can be made for it, without departing from appended right
The spirit and scope of the present invention that claim is limited.
Claims (7)
1. one kind contains antibiotic in pyrimidine nucleoside class and the bactericidal composition of hymexazol, it is characterised in that active component is pyrimidine core
Glycoside antibiotics and hymexazol, wherein, antibiotic in pyrimidine nucleoside class and hymexazol weight ratio are 32:3-1:48.
Bactericidal composition the most according to claim 1, it is characterised in that above-mentioned antibiotic in pyrimidine nucleoside class and hymexazol weight
Amount ratio is 2:3-1:24.
Bactericidal composition the most according to claim 2, it is characterised in that above-mentioned antibiotic in pyrimidine nucleoside class and hymexazol weight
Amount ratio is 1:6.
Bactericidal composition the most according to claim 1, it is characterised in that two kinds of active components in above-mentioned bactericidal composition
Weight percentage is 2-70%.
Bactericidal composition the most according to claim 4, it is characterised in that two kinds of active components in above-mentioned bactericidal composition
Weight percentage is 70%.
Bactericidal composition the most according to claim 1, it is characterised in that above-mentioned bactericidal composition also comprises auxiliary agent, described
One or more in emulsifying agent, dispersant, wetting agent, disintegrating agent, binding agent of auxiliary agent.
7. according to the bactericidal composition described in any one of claim 1-6, it is characterised in that the dosage form of described bactericidal composition is
Wettable powder, water preparation or water dispersible granules.
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