CN104322496B - A kind of composition pesticide containing cyprodinil and propamidine - Google Patents

Abstract

The invention discloses a pesticide composition containing cyprodinil and propamidine, which comprises common adjuvants, cyprodinil and propamidine, and the weight ratio of cyprodinil to propamidine is 30:1-1 : 7, the weight percentage of the total weight of cyprodinil and propamidine in the pesticide composition is 3% to 90%. The combination of cyprodinil and propamidine has obvious synergistic effect, and the dosage of the active ingredients of the compound agent is significantly less than that used alone. It is suitable for the prevention and treatment of crop diseases caused by pathogenic fungi, especially those caused by Botrytis spp. ) Crop gray mold caused by pathogens, crop sclerotinia caused by Sclerotinia pathogens.

Description

A kind of pesticide composition containing cyprodinil and propamidine

technical field

The present invention relates to a kind of pesticide composition, specifically a kind of pesticide composition containing cyprodinil and propamidine.

Background technique

Cyprodinil is a methionine biosynthesis inhibitor, which has protective, therapeutic and systemic activities, and is mainly used to control crop diseases such as botrytis cinerea, sclerotinia, powdery mildew, scab and leaf spot.

Propamidine, English common name Propamidine, is an aromatic diamidine compound. Propamidine is a systemic fungicide, which can be absorbed, distributed and metabolized in plants, and has protective and therapeutic effects. Botrytis cinerea caused by crops.

The mixing of different pesticide varieties is a common method to control agricultural resistant diseases. Through the screening of pesticide formulations, screening out reasonable formulations can effectively improve the actual control effect, reduce the amount of pesticides used, reduce costs, and delay the emergence of disease resistance. It is an important means of comprehensive disease management.

The combination of cyprodinil and propamidine enhances the protective effect on crops, and at the same time reduces the risk of resistance caused by using cyprodinil or propamidine alone. There is no report on the combination of cyprodinil and propamidine.

Contents of the invention

The technical problem to be solved in the present invention is to provide a pesticide composition containing cyprodinil and propamidine that is highly efficient, low in toxicity, good in quick effect and long in effect, and beneficial to the comprehensive management of diseases.

In order to solve the problems referred to above, the technical scheme adopted in the present invention is: a kind of pesticide composition containing cyprodinil and propamidine, comprising common auxiliary agent and cyprodinil and propamidine, the weight of cyprodinil and propamidine The parts ratio is 30:1-1:7, and the weight percentage of the weight sum of cyprodinil and propamidine in the pesticide composition is 3%-90%.

Further: the above-mentioned pesticide composition containing cyprodinil and propamidine can be configured into suspension concentrate, dispersible oil suspension concentrate, water dispersible granule, Wet powder and other formulations suitable for agricultural use.

The pesticide adjuvants used in the pesticide composition of the present invention include solvents, emulsifiers, wetting agents, disintegrants, stabilizers, dispersants, thickeners, penetration enhancers, pH regulators, defoamers, antifreezes, Carriers and other known substances that are beneficial to the stability and efficacy of active ingredients in the formulation are all commonly used or allowed ingredients in pesticide formulations, and the specific ingredients and dosage are determined through experiments according to the formulation requirements.

The application frequency and application amount of the pesticide composition of the present invention have small changes with changes in crops, pests, and weather conditions, and the purpose of effective control can be achieved by using an appropriate dosage.

The pesticide composition of the present invention is suitable for preventing and treating crop diseases caused by pathogenic fungi, especially botrytis botrytis caused by pathogens of the genus Botritis and sclerotinia caused by pathogens of the genus Sclerotinia.

Compared with the prior art, the present invention has the advantages of:

1. The control effect of the pesticide composition of the present invention has obviously improved than single agent, has reduced the use dosage of pesticide, has reduced cost.

2. The active ingredients of the pesticide composition of the present invention have different mechanisms of action, and the application of the composition can delay or overcome the generation of drug resistance of pathogens, which is beneficial to comprehensive management.

detailed description

The pesticide composition of the present invention includes common adjuvants and cyprodinil and propamidine, the weight ratio of cyprodinil and propamidine is 30:1-1:7, and the weight sum of cyprodinil and propamidine is in the pesticide combination The weight percentage in the product is 3%～90%. That is to say, the present invention obtains a preferred formula through trial and error, which shows obvious synergistic effect, and the control effect of the composition is significantly improved compared with a single agent, which reduces the dosage of pesticides and reduces the cost.

Below in conjunction with embodiment the content of the present invention is described in further detail, the content mentioned in the embodiment is not limitation of the present invention, the selection of process conditions such as temperature, time in the preparation method can adjust measures to local conditions and have no substantial impact on the result.

Example 1.

The following substances are all percentages by weight: cyprodinil 20%, propaneamidine 20%, calcium lignosulfonate 3%, calcium dodecylbenzenesulfonate 3%, lauryl betaine 5%, fatty alcohol poly 5% oxyethylene ether, 5% glycerin, 0.1% gum arabic, and the balance is deionized water; the above formula is pre-crushed in proportion, then added to a sand mill for grinding, and prepared after high-shear mixing 40% Cyprodinil Propanamidine Suspension Concentrate.

This embodiment is used to control lettuce sclerotinia. 40% cyprodinil·propaneamidine suspension was diluted with 180g.a.i./ha and sprayed with water, and the control effects were 94.2% and 89.3% after 7 days and 14 days after the drug; 50% cyprodinil water dispersible granules were 240g.a.i./ha was diluted with water, and the control effects were 84.1% and 70.7% after 7 days and 14 days after the application; 2% propaneamidine water was diluted with 240g.a.i./ha and sprayed with water, and the prevention effect was 7 days and 14 days after the application. The efficiency is 82.6% and 70.9% respectively. The synergistic effect of cyprodinil and propamidine is obvious after compounding, and the control effect on lettuce sclerotinia is obviously better than that of single agent. The amount of active ingredients in the compound agent is significantly less than that when used alone, and the total active ingredients are also relatively reduced. , thereby reducing the environmental load and reducing the cost of use.

Example 2.

The following substances are all percentages by weight: cyprodinil 20%, propaneamidine 10%, sodium lignosulfonate 4%, styrene phenol polyoxyethylene ether 5%, methyl oleate 25%, organic bentonite 8%, ten Dialkyl calcium sulfonate 6%, the balance is turpentine; the above formula is pre-crushed in proportion, then added to a sand mill for grinding, and after high-shear mixing, 30% cyprodinil propamidine can be prepared. Disperse oil suspension.

This embodiment is used to control Botrytis cinerea. 30% cyprodinil·propaneamidine dispersible oil suspension was diluted with water at 500mg/kg and sprayed, and the control effects were 91.6% and 85.7% after 7 days and 14 days after the drug; 50% cyprodinil water dispersible granules Add water to 600mg./kg and spray, and the control effect is 83.1% and 70.5% after 7 days and 14 days after the drug; 2% propaneamidine water is diluted and sprayed at 600 mg/kg, and the control effect is 7 days and 14 days after the drug They are 82.6% and 69.5% respectively. The compounding of cyprodinil and propamidine has obvious synergistic effect, and the control effect on botrytis cinerea is significantly better than that of single agent. The dosage of active ingredients in the compound agent is significantly less than that when used alone, and the total active ingredients are also relatively reduced. , thereby reducing the environmental load and reducing the cost of use.

Example 3.

The following materials are all percentages by weight: 45% of cyprodinil, 15% of propamidine, 4% of calcium lignosulfonate, 6% of polycarboxylate, 5% of glucose, 4% of naphthalenesulfonate, and the balance is kaolin. The above formula is dry crushed, granulated, dried and sieved according to the proportion to prepare 60% cyprodinil·propaneamidine water dispersible granules.

This embodiment is used to control celery gray mold. 60% cyprodinil·propaneamidine water dispersible granules are diluted with water at 150g.a.i./ha and sprayed, and the control effects are 91.5% and 84.7% after 7 days and 14 days after the drug; 50% cyprodinil water dispersible granules 180g.a.i./ha was diluted with water and sprayed, and the control effects were 81.8% and 71.7% respectively 7 days and 14 days after the application; The natural anti-effects were 82.7% and 70.6% respectively. The compounding of cyprodinil and propamidine has obvious synergistic effect, and the control effect on celery botrytis is obviously better than that of single agent. The amount of active ingredients in the compound agent is significantly less than that when used alone, and the total active ingredients are also relatively reduced. , thereby reducing the environmental load and reducing the cost of use.

Example 4.

The following substances are all percentages by weight: 35% of cyprodinil, 15% of propaneamidine, 5% of calcium lignosulfonate, 4% of sodium lauryl sulfate, 5% of sodium butylnaphthalenesulfonate, and 5% of white carbon black , and the balance is kaolin. The above formula is coarsely pulverized in proportion, put into a mixer and mixed uniformly, and then pulverized by air flow to obtain 50% cyprodinil·propaneamidine wettable powder.

This embodiment is used to prevent and treat Sclerotinia sclerotiorum. 50% cyprodinil·propaneamidine wettable powder is diluted with water at 120g.a.i./ha and sprayed, and the control effects of 7 days and 14 days after the drug are 94.0% and 83.4% respectively; 50% cyprodinil water dispersible granules According to 150g.a.i./ha after 7 days and 14 days, the control effects are 83.1% and 71.4% respectively; 2% propaneamidine water spray is diluted with water at 150g.a.i./ha, and the 7 days and 14 days after treatment are respectively 84.0%, 72.7%. The compounding of cyprodinil and propamidine has obvious synergistic effect, and the control effect on Sclerotinia sclerotiorum is obviously better than that of single agent. The amount of active ingredients in the compound agent is significantly less than that when used alone, and the total active ingredients are also relatively reduced. , thereby reducing the environmental load and reducing the cost of use.

Example 5.

In order to further understand the joint action type of the mixture of cyprodinil and propamidine, the inventors have carried out a large number of indoor toxicity determination tests on the mixture of cyprodinil and propamidine.

According to Sun Yunpei's method, the synergistic effect of drug mixture is evaluated according to the co-toxicity coefficient (CTC), that is, CTC≤80 is synergistic antagonism, 80<CTC<120 is synergistic antagonism, and CTC≥120 is synergistic effect.

Actual toxicity index (ATI) = (EC ₅₀ of standard drug / EC ₅₀ of test drug) × 100;

Theoretical toxicity index TTI = toxicity index of agent A × percentage content of agent A in the mixture + toxicity index of agent B × percentage content of agent B in the mixture;

Co-toxicity coefficient (CTC) = [measured toxicity index (ATI) of mixture/theoretical toxicity index (TTI) of mixture] × 100.

(1) Indoor toxicity test for Botrytis cinerea.

The test object is Botrytis cinerea, the pathogen of tomato cinerea, collected from the field. The method refers to the "People's Republic of China Agricultural Industry Standard NY/T 1156.6-2006", the mycelial growth rate method.

Table 1, cyprodinil Propanamidine indoor toxicity test result to botrytis cinerea (Botrytis cinerea).

It can be seen from Table 1 that the mixture of cyprodinil and propamidine at a ratio of 30:1 to 1:7 has obvious synergistic effect on Botrytis cinerea (Botrytiscinerea), and the co-toxicity coefficients are all above 140.

(2) Indoor toxicity test for Sclerotinia sclerotiorum .

The test object is Sclerotinia sclerotiorum , the pathogen of lettuce sclerotiorum collected from the field, and the method refers to the growth rate method of "The Agricultural Industry Standard of the People's Republic of China NY/T 1156.6-2006".

Table 2. Indoor toxicity test results of cyprodinil·propaneamidine against Sclerotinia sclerotiorum .

It can be seen from Table 2 that the mixture of cyprodinil and propamidine at a ratio of 15:1 to 3:1 has obvious synergistic effect on Sclerotinia sclerotiorum , and the co-toxicity coefficients are all above 160.

In summary, the combination of cyprodinil and propamidine is reasonable and feasible.

Claims (4)

1. A kind of 1. composition pesticide containing cyprodinil and propamidine, it is characterised in that：Active ingredient is cyprodinil and third Alkane amidine, cyprodinil and propamidine ratio of weight and number are 30:1~1:3, cyprodinil and propamidine weight summation are in pesticide combination Percentage by weight in thing is 3%~90%.
2. 2. composition pesticide according to claim 1, it is characterised in that：Also contain pesticidal preparations in the composition pesticide Auxiliary element.
3. 3. the composition pesticide described in claim 1 is in preventing and treating by the application in the fungus-caused crop disease of pathogen.
4. 4. composition pesticide according to claim 3 is being prevented and treated by the application in the fungus-caused crop disease of pathogen, It is characterized in that：Described by the fungus-caused crop disease of pathogen is gray mold, sclerotiniose.