CN104258359A - Traditional Chinese medicine combination for curing pregnancy reaction and preparation method of preparations thereof - Google Patents
Traditional Chinese medicine combination for curing pregnancy reaction and preparation method of preparations thereof Download PDFInfo
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- CN104258359A CN104258359A CN201410555480.8A CN201410555480A CN104258359A CN 104258359 A CN104258359 A CN 104258359A CN 201410555480 A CN201410555480 A CN 201410555480A CN 104258359 A CN104258359 A CN 104258359A
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Abstract
The invention discloses a traditional Chinese medicine combination for curing pregnancy reaction. The traditional Chinese medicine combination is prepared by the following bulk drugs: 10 to 20 parts of bamboo shavings, 20 to 30 parts of dangshen, 10 to 20 parts of red tangerine peel, 4 to 6 parts of amomum fruit, 20 to 30 parts of bighead atractylodes rhizome, 25 to 35 parts of coix seed, 8 to 12 parts of perilla stem, 10 to 20 parts of Indian bread, 8 to 12 parts of licorice root, 10 to 20 parts of root of herbaceous peony, 4 to 8 parts of fresh ginger, 4 to 8 parts of Chinese date, and 2 to 4 parts of pepper mint. The preparations of the traditional Chinese medicine combination comprise water decoction, capsule, tablet, granules, water pill and honeyed pill. According to clinical characters of combination, the traditional Chinese medicine combination for curing pregnancy reaction does not have side-effects of chemical drugs, and can be taken for a long time.
Description
Technical field
The present invention relates to and be a kind ofly used for the treatment of the Chinese medicine composition of gestation reaction and the preparation method of preparation thereof, belong to tcm field.
Background technology
Gestation reaction is in First Trimester (menolipsis about six weeks), in anemia of pregnant woman's body, chorionic-gonadotropin hormone (HCG) increases, gastric acid secretion reduces and the gastric emptying time extends, cause dizziness, weak, inappetence, like sour food or detest greasy, feel sick, morning plays the series reaction such as vomiting, be referred to as morning sickness, the gestation reaction of anemia of pregnant woman is serious, show and occur serious nausea and vomiting, cannot take food, namely " hyperemesis gravidarum " medically, because the energy shortage in body and nutrient substance shortage can cause the organic impairment of health: liver function and renal dysfunction, Electrolyte imbalance etc. in body, the cause of disease of hyperemesis gravidarum is not bright so far may be main relevant with the dysequilibrium of hormone in vivo mechanism of action and the mental status.And functions of hormones means at First Trimester when vomiting during pregnancy is the most serious, in body, hCG level is the highest; HCG concentration in twin pregnancy or hydatidiform mole patient blood obviously increases and the person of hypermesising also significantly increases, and all points out that this disease and hCG's is in close relations.In addition as hypoadrenocorticism, then its glucocorticoid secretion is not enough, thus make water and carbohydate metabolism disorder in body, when there is the symptoms of digestive tract such as nausea and vomiting and apply ACTH or corticosteroid therapy, symptom can obviously be improved, therefore also think that adrenal cortex function reduces and also has with hyperemesis gravidarum certain relation to have to think Vitamin B6 deficiency also may be that one of reason of falling ill all can cause and vomits aggravation and have severe dysmenorrhea history person, there is increasing of hyperemesis gravidarum, primary disease western medical treatment is only limitted to symptomatic treatment, oral vitamin B
6only nausea and vomiting, various dietetic regulation, but poor effect, the present invention is directed to the deficiency of above-mentioned treatment, a kind of Chinese medicine composition for the treatment of gestation reaction is provided, weak, inappetence, the happiness acid food of obvious alleviation gestation reaction or detest greasy, nauseating, morning and play the series reaction such as vomiting, and evident in efficacy, the present invention has no side effect.
Summary of the invention
The problem to be solved in the present invention is for above deficiency, provides a kind of and is used for the treatment of the Chinese medicine composition of gestation reaction and the preparation method of preparation thereof.
Technical scheme of the present invention is:
Be used for the treatment of a Chinese medicine composition for gestation reaction, be made up of the raw material of following weight portion:
Caulis Bambusae In Taenia 10-20 part, Radix Codonopsis 20-30 part, Exocarpium Citri Rubrum 10-20 part, Fructus Amomi 4-6 part, Rhizoma Dioscoreae 20-30 part, Semen Coicis 25-35 part, Caulis Perillae 8-12 part, Poria 10-20 part, Radix Glycyrrhizae 8-12 part, Radix Paeoniae Alba 10-20 part, Rhizoma Zingiberis Recens 4-8 part, Fructus Jujubae 4-8 part, Herba Menthae 2-4 part.
As technique scheme further preferably, described Chinese medicine composition is made up of the raw material of following weight portion:
Caulis Bambusae In Taenia 15 parts, Radix Codonopsis 25 parts, Exocarpium Citri Rubrum 15 parts, Fructus Amomi 5 parts, Rhizoma Dioscoreae 25 parts, Semen Coicis 30 parts, Caulis Perillae 10 parts, 15 parts, Poria, 10 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 15 parts, 6 parts, Rhizoma Zingiberis Recens, 6 parts, Fructus Jujubae, Herba Menthae 3 parts.
Described Chinese medicine composition pharmaceutical dosage form is: water decoction, capsule, tablet, granule, watered pill, honey pill agent.
According to the present invention, prepare a kind of method for the treatment of the Chinese medicinal composition preparation of gestation reaction, comprise the following steps:
A, general: Caulis Bambusae In Taenia, Radix Codonopsis, Exocarpium Citri Rubrum, Fructus Amomi, Rhizoma Dioscoreae, Semen Coicis, Caulis Perillae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, Herba Menthae mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol;
B, the filtrate of above-mentioned steps a is condensed into the thick extractum that 80 DEG C record relative density 1.21 ~ 1.25, obtains unguentum;
C, the filtrate of above-mentioned steps b is concentrated into paste, gets thick paste, add appropriate sucrose and dextrin, make granule, dry, make 1000 parts (sugar-containing types), obtain granule;
D, the filtrate of above-mentioned steps b is concentrated into paste, shift-in baking oven, dries to moisture lower than 5%, take out, pulverize and sieve to 100 orders, obtain drug powder, add adjuvant by prior art, make capsule or enteric coated tablet for 50-70 DEG C;
E, proportionally get each composition of raw material mixing, pulverize, cross 80 ~ 100 mesh sieves, obtain medicated powder.By the cold boiled water of medicated powder after sieving or Sucus Zingberis general be piller, cold drying, quality inspection, packs and obtains watered pill;
F, separately get sucrose 90g, add water 45ml and refined honey 90g, mixing, and when refining to refining is measured as 1.38 to relative density 70 DEG C, filters, mix, pill block with the medicated powder 200g of above-mentioned steps f, rub ball bar with the hands, pill grain, every ball weighs 9g, obtains honey pill agent.
According to the present invention, a kind of water decoction for the treatment of the Chinese medicinal composition preparation of gestation reaction:
Proportionally get the mixing of each composition of raw material, decoct with water 30 minutes and obtain water decoction.
In above raw material:
Caulis Bambusae In Taenia: function cures mainly removing heat-phlegm, relieves restlessness and prevents vomiting.Expectorant, dysphoria with smothery sensation vomiting, palpitation with fear insomnia, middle wind-phlegm fan, gastropyretic vomiting, pregnancy reactions, frequent fetal movement is held under the arm for phlegm-heat cough, gallbladder fire
Radix Codonopsis: property is put down, sweet in the mouth, micro-acid.Return spleen, lung meridian.Invigorating the spleen and replenishing QI, spleen invigorating lung benefiting.For deficiency of the spleen and lung, cardiopalmus of breathing hard, anorexia and loose stool, dyspnea due to deficiency is coughed, and interior-heat is quenched one's thirst.
Exocarpium Citri Rubrum: pungent, bitter, temperature.Return lung, spleen channel.Cold expelling, dampness, promoting the circulation of QI, expectorant.For cough due to wind and cold, itching of the throat abundant expectoration, food stagnation is got sick from drinking too much wine, and vomiting and nausea painful abdominal mass is vexed.Clinical practice proves, has unique curative effect to pulmonary tuberculosis, bronchitis, long-term stomachache, relieving cough and resolving phlegm etc.
Fructus Amomi: circulation of qi promoting stomach invigorating.For abdominal distention, anorexia that stagnation of QI in spleen and stomach causes, many and Pericarpium Citri Reticulatae, the Radix Aucklandiae are used together.Removing dampness preventing or arresting vomiting.For all cards of the vexed vomiting and nausea of gastral cavity that taste humidity hysteresis causes.Antiabortive.For vomiting during pregnancy, frequent fetal movement, many with fill blood, kidney-reinforcing drug is with using.
Rhizoma Dioscoreae: Rhizoma Dioscoreae nature and flavor are sweet flat, people's lung, spleen, stomach warp, have spleen invigorating, tonifying the lung, reinforce the kidney, benefit essence, longue meat, take clear-headed and clear-sighted effect for a long time, to old man's dysuria or urine too much, diabetes, physical weakness, tired unable, inappetence, dyspnea due to deficiency abundant expectoration, seminal emission nebulousurine, nervous hyperhidrosis, palm of the hand slight fever etc. have therapeutic effect.The soap two particularly contained in Rhizoma Dioscoreae can adjust abdominal distention, after being ill weak, diarrhoea, and lung benefiting cough-relieving, reduces blood glucose, life lengthening, anti-hepatic coma, kidney nourishing and replenishing vital essence, invigorating spleen and reinforcing stomach, aid digestion.
Semen Coicis: dampness removing eliminating impediment, clearing away heat and discharging pus, eliminating damp-heat, have loose bowels, effect of muscle arteries and veins contracture etc.
Caulis Perillae: regulate the flow of vital energy, Shu Yu, pain relieving, antiabortive.Control the stagnation of QI, dyspepsia, chest and diaphragm painful abdominal mass is vexed, epigastric pain, and nausea is got along well.
Poria: Poria sweet in the mouth, light, property are put down, can eliminating dampness and diuresis; Invigorating the spleen and regulating the stomach; Mind tranquilizing and the heart calming.Cure mainly dysuria; Edema distension; Phlegm retention cough with dyspnea; Vomiting; Insufficiency of the spleen lack of appetite; Have loose bowels; Palpitation and restlessness; Insomnia forgetfulness; Seminal emission nebulousurine.
Radix Glycyrrhizae: Radix Glycyrrhizae invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
The Radix Paeoniae Alba: bitter, sour, is slightly cold.Enter Liver Channel.Nourish blood yin fluid astringing, easing the affected liver to relieve pain, suppressing the hyperactive liver sun.For menoxenia, abdominal pain during menstruation, metrorrhagia, and the disease such as spontaneous perspiration, night sweat.
Rhizoma Zingiberis Recens:: Rhizoma Zingiberis Recens acrid in the mouth, warm in nature. return lung, spleen, stomach warp. effect is induced sweat cold expelling, warming middle-JIAO arresting vomiting by invigorating the stomach, Hua Tanzhike
Fructus Jujubae: invigorating the spleen and replenishing QI, nourishing blood to tranquillize the mind.For insufficiency of the spleen lack of appetite, weak loose stool
Herba Menthae: acrid in the mouth, cool in nature.Return lung, Liver Channel, have and disperse wind heat, clearing throat, rash is detoxified, dispersing the stagnated live-QI to relieve the stagnation of QI and the effect such as antipruritic, be applicable to the disease such as cold, fever, headache, laryngopharynx swelling and pain, lossless, wind-fire acute conjunctivitis, rubella, skin are itched, colic, dysentery and scrofula, external has slight analgesic effect, for neuralgia etc.
The present invention adopts above technical scheme, compared with prior art, has the following advantages: monarch of the present invention, minister, help, make respectively to execute its effect, has medication few, instant effect, has no side effect to anemia of pregnant woman, can reach inside and outside and execute, the object of giving consideration to both the incidental and fundamental.Rather good to gestation reaction curative effect, can long-term taking, and the prices of raw and semifnished materials are cheap, simple to operate, therapeutic effect is good, is worthy of popularization.
Detailed description of the invention
Below in conjunction with embodiment, the invention will be further described.
Embodiment 1: a kind of Chinese medicine composition being used for the treatment of gestation reaction, raw-material weight part is:
Caulis Bambusae In Taenia 10 parts of Radix Codonopsis 20 parts of Exocarpium Citri Rubrums 10 parts of Fructus Amomis 4 portions of Rhizoma Dioscoreaes 20 parts of Semen Coiciss 25 parts of Caulis Perillaes 8 parts of Poria 10 portions of Radix Glycyrrhizaes 8 portions of Radix Paeoniae Albas 10 portions of Rhizoma Zingiberis Recenss 4 portions of Fructus Jujubaes 4 portions of Herba Menthaes 2 parts.
Embodiment 2: a kind of Chinese medicine composition being used for the treatment of gestation reaction, raw-material weight part is:
Caulis Bambusae In Taenia 20 parts of Radix Codonopsis 30 parts of Exocarpium Citri Rubrums 20 parts of Fructus Amomis 6 portions of Rhizoma Dioscoreaes 30 parts of Semen Coiciss 35 parts of Caulis Perillaes 12 parts of Poria 20 portions of Radix Glycyrrhizaes 12 portions of Radix Paeoniae Albas 20 portions of Rhizoma Zingiberis Recenss 8 portions of Fructus Jujubaes 8 portions of Herba Menthaes 4 parts.
Embodiment 3: a kind of Chinese medicine composition being used for the treatment of gestation reaction, raw-material weight part is: Caulis Bambusae In Taenia 15 parts of Radix Codonopsis 25 parts of Exocarpium Citri Rubrums 15 parts of Fructus Amomis 5 portions of Rhizoma Dioscoreaes 25 parts of Semen Coiciss 30 parts of Caulis Perillaes 10 parts of Poria 15 portions of Radix Glycyrrhizaes 10 portions of Radix Paeoniae Albas 15 portions of Rhizoma Zingiberis Recenss 6 portions of Fructus Jujubaes 6 portions of Herba Menthaes 3 parts.
Embodiment 4: the medicine of above embodiment 1-3 is prepared into different dosage forms according to following steps: water decoction, unguentum, granule, capsule, enteric coated tablet, watered pill, honey pill agent.：
A, proportionally get each composition of raw material mixing, decoct with water 30 minutes water decoction.
B, general: Caulis Bambusae In Taenia, Radix Codonopsis, Exocarpium Citri Rubrum, Fructus Amomi, Rhizoma Dioscoreae, Semen Coicis, Caulis Perillae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, Herba Menthae mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol;
C, the filtrate of above-mentioned steps b is condensed into the thick extractum that 80 DEG C record relative density 1.21 ~ 1.25, obtains unguentum;
D, the filtrate of above-mentioned steps b is concentrated into paste, gets thick paste, add appropriate sucrose and dextrin, make granule, dry, make 1000 parts (sugar-containing types), obtain granule;
E, the filtrate of above-mentioned steps b is concentrated into paste, shift-in baking oven, dries to moisture lower than 5%, take out, pulverize and sieve to 100 orders, obtain drug powder, add adjuvant by prior art, make capsule or enteric coated tablet for 50-70 DEG C;
F, proportionally get each composition of raw material mixing, pulverize, cross 80 ~ 100 mesh sieves, obtain medicated powder.By the cold boiled water of medicated powder after sieving or Sucus Zingberis general be piller, cold drying, quality inspection, packs and obtains watered pill;
G, separately get sucrose 90g, add water 45ml and refined honey 90g, mixing, and when refining to refining is measured as 1.38 to relative density 70 DEG C, filters, mix, pill block with the medicated powder 200g of above-mentioned steps f, rub ball bar with the hands, pill grain, every ball weighs 9g, obtains honey pill agent.
Proportionally get the mixing of each composition of raw material, decoct with water 30 minutes and obtain water decoction.
Criterion of therapeutical effect:
Adopt the diagnosis basis of pregnancy reactions in " TCM Gynecology disease Standardization of diagnosis and curative effect ", card marquis classification, efficacy evaluation:
Cure: vomiting stops, all diseases are eliminated, and after drug withdrawal, nothing repeatedly.
Take a turn for the better: the diseases such as vomiting alleviate.Or vomit the elimination of all diseases, but see recurrence again after drug withdrawal.
Do not heal (invalid): vomit all diseases all without improvement.
Choose 400 routine gestation reaction patients, random selecting 300 example is as treatment group, other 100 examples as a control group, wherein 300 routine patients are divided into treatment group 1, treatment group 2 and treatment group 3,100 routine patients of each treatment group treatment random selecting, treatment group 1 uses the water decoction of the embodiment of the present invention 1 to treat, and treatment group 2 uses the decocting of the embodiment of the present invention 2 to treat, and treatment group 3 uses the water decoction of the embodiment of the present invention 3 to treat
The patient of matched group adopts vitamin B for oral administration
6coordinate dietetic regulation.
Therapeutic outcome is as following table:
As can be seen from above tables of data, treatment group effective percentage cure rate is apparently higher than matched group, and the cure rate effective percentage for the treatment of group 3 is higher than all the other treatment groups 1 and treatment group 2, and treatment group 3 prescription is the most effective in sum.
Claims (4)
1. be used for the treatment of a Chinese medicine composition for gestation reaction, be made up of the raw material of following weight portion:
Caulis Bambusae In Taenia 10-20 part, Radix Codonopsis 20-30 part, Exocarpium Citri Rubrum 10-20 part, Fructus Amomi 4-6 part, Rhizoma Dioscoreae 20-30 part, Semen Coicis 25-35 part, Caulis Perillae 8-12 part, Poria 10-20 part, Radix Glycyrrhizae 8-12 part, Radix Paeoniae Alba 10-20 part, Rhizoma Zingiberis Recens 4-8 part, Fructus Jujubae 4-8 part, Herba Menthae 2-4 part.
2. a kind of Chinese medicine composition being used for the treatment of gestation reaction as claimed in claim 1, be made up of the raw material of following weight portion:
Caulis Bambusae In Taenia 15 parts, Radix Codonopsis 25 parts, Exocarpium Citri Rubrum 15 parts, Fructus Amomi 5 parts, Rhizoma Dioscoreae 25 parts, Semen Coicis 30 parts, Caulis Perillae 10 parts, 15 parts, Poria, 10 parts, Radix Glycyrrhizae, the Radix Paeoniae Alba 15 parts, 6 parts, Rhizoma Zingiberis Recens, 6 parts, Fructus Jujubae, Herba Menthae 3 parts.
3. preparation a kind of method being used for the treatment of the Chinese medicine composition of gestation reaction as claimed in claim 1 or 2, comprises the following steps:
A, general: Caulis Bambusae In Taenia, Radix Codonopsis, Exocarpium Citri Rubrum, Fructus Amomi, Rhizoma Dioscoreae, Semen Coicis, Caulis Perillae, Poria, Radix Glycyrrhizae, the Radix Paeoniae Alba, Rhizoma Zingiberis Recens, Fructus Jujubae, Herba Menthae mixing, add 75% alcohol reflux 1-2 hour of 5-6 times amount volume, filter, get filtrate, filtering residue repeats backflow 2-3 time, merging filtrate; Reclaim ethanol;
B, the filtrate of above-mentioned steps a is condensed into the thick extractum that 80 DEG C record relative density 1.21 ~ 1.25, obtains unguentum;
C, the filtrate of above-mentioned steps b is concentrated into paste, gets thick paste, add appropriate sucrose and dextrin, make granule, dry, make 1000 parts, obtain granule;
D, the filtrate of above-mentioned steps b is concentrated into paste, shift-in baking oven, dries to moisture lower than 5%, take out, pulverize and sieve to 100 orders, obtain drug powder, add adjuvant by prior art, make capsule or enteric coated tablet for 50-70 DEG C;
E, proportionally get each composition of raw material mixing, pulverize, cross 80 ~ 100 mesh sieves, obtain medicated powder.By the cold boiled water of medicated powder after sieving or Sucus Zingberis general be piller, cold drying, quality inspection, packs and obtains watered pill;
F, separately get sucrose 90g, add water 45ml and refined honey 90g, mixing, and when refining to refining is measured as 1.38 to relative density 70 DEG C, filters, mix, pill block with the medicated powder 200g of above-mentioned steps f, rub ball bar with the hands, pill grain, every ball weighs 9g, obtains honey pill agent.
4. a kind of Chinese medicine composition being used for the treatment of gestation reaction as claimed in claim 1 or 2, described Chinese medicine composition pharmaceutical dosage form is: water decoction, capsule, tablet, granule, watered pill, honey pill agent.
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Application publication date: 20150107 |
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