CN104055701A - Anti-allergy conditioning shampoo - Google Patents
Anti-allergy conditioning shampoo Download PDFInfo
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- CN104055701A CN104055701A CN201410257009.0A CN201410257009A CN104055701A CN 104055701 A CN104055701 A CN 104055701A CN 201410257009 A CN201410257009 A CN 201410257009A CN 104055701 A CN104055701 A CN 104055701A
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- chinese medicine
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- conditioning shampoo
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- 239000002453 shampoo Substances 0.000 title claims abstract description 46
- 230000003750 conditioning effect Effects 0.000 title claims abstract description 25
- 230000003266 anti-allergic effect Effects 0.000 title claims abstract description 24
- 239000003814 drug Substances 0.000 claims abstract description 40
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims abstract description 36
- 229920002674 hyaluronan Polymers 0.000 claims abstract description 36
- 229960003160 hyaluronic acid Drugs 0.000 claims abstract description 36
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 38
- 241000120569 Streptococcus equi subsp. zooepidemicus Species 0.000 claims description 26
- 238000002360 preparation method Methods 0.000 claims description 21
- 241000628997 Flos Species 0.000 claims description 16
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 16
- 238000004321 preservation Methods 0.000 claims description 13
- 239000000203 mixture Substances 0.000 claims description 11
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 claims description 8
- 241001116389 Aloe Species 0.000 claims description 8
- 239000003390 Chinese drug Substances 0.000 claims description 8
- ZGTMUACCHSMWAC-UHFFFAOYSA-L EDTA disodium salt (anhydrous) Chemical compound [Na+].[Na+].OC(=O)CN(CC([O-])=O)CCN(CC(O)=O)CC([O-])=O ZGTMUACCHSMWAC-UHFFFAOYSA-L 0.000 claims description 8
- 241000533849 Gleditsia Species 0.000 claims description 8
- 239000005639 Lauric acid Substances 0.000 claims description 8
- 235000011399 aloe vera Nutrition 0.000 claims description 8
- 239000008367 deionised water Substances 0.000 claims description 8
- 229910021641 deionized water Inorganic materials 0.000 claims description 8
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 8
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims description 8
- 229940069338 potassium sorbate Drugs 0.000 claims description 8
- 235000010241 potassium sorbate Nutrition 0.000 claims description 8
- 239000004302 potassium sorbate Substances 0.000 claims description 8
- 239000001509 sodium citrate Substances 0.000 claims description 8
- HRXKRNGNAMMEHJ-UHFFFAOYSA-K trisodium citrate Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O HRXKRNGNAMMEHJ-UHFFFAOYSA-K 0.000 claims description 8
- 229940038773 trisodium citrate Drugs 0.000 claims description 8
- 238000000605 extraction Methods 0.000 claims description 7
- IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 claims description 4
- 238000010438 heat treatment Methods 0.000 claims description 4
- 238000011084 recovery Methods 0.000 claims description 4
- 238000010992 reflux Methods 0.000 claims description 4
- 239000002904 solvent Substances 0.000 claims description 4
- 238000005507 spraying Methods 0.000 claims description 4
- 230000000694 effects Effects 0.000 abstract description 18
- 238000005406 washing Methods 0.000 abstract description 8
- AEMOLEFTQBMNLQ-AQKNRBDQSA-N D-glucopyranuronic acid Chemical compound OC1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O AEMOLEFTQBMNLQ-AQKNRBDQSA-N 0.000 abstract description 7
- 208000001840 Dandruff Diseases 0.000 abstract description 7
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- 229940097043 glucuronic acid Drugs 0.000 abstract description 7
- 230000003020 moisturizing effect Effects 0.000 abstract description 5
- 230000006378 damage Effects 0.000 abstract description 4
- 238000005202 decontamination Methods 0.000 abstract description 2
- 230000003588 decontaminative effect Effects 0.000 abstract description 2
- 238000009499 grossing Methods 0.000 abstract 1
- 231100000344 non-irritating Toxicity 0.000 abstract 1
- 230000003658 preventing hair loss Effects 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 description 27
- 230000004151 fermentation Effects 0.000 description 27
- 244000005700 microbiome Species 0.000 description 15
- 239000000047 product Substances 0.000 description 12
- 238000003756 stirring Methods 0.000 description 12
- 230000018044 dehydration Effects 0.000 description 10
- 238000006297 dehydration reaction Methods 0.000 description 10
- 238000001914 filtration Methods 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 9
- 238000005516 engineering process Methods 0.000 description 9
- 239000010451 perlite Substances 0.000 description 9
- 235000019362 perlite Nutrition 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 8
- 239000000706 filtrate Substances 0.000 description 8
- 239000000463 material Substances 0.000 description 8
- 238000001556 precipitation Methods 0.000 description 8
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 7
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 7
- 229910052799 carbon Inorganic materials 0.000 description 7
- 239000012535 impurity Substances 0.000 description 7
- 208000027418 Wounds and injury Diseases 0.000 description 6
- 208000014674 injury Diseases 0.000 description 6
- 238000004519 manufacturing process Methods 0.000 description 6
- 230000003648 hair appearance Effects 0.000 description 5
- -1 polypropylene Polymers 0.000 description 5
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 4
- 206010020880 Hypertrophy Diseases 0.000 description 4
- 239000004743 Polypropylene Substances 0.000 description 4
- 241001052560 Thallis Species 0.000 description 4
- 230000001476 alcoholic effect Effects 0.000 description 4
- 230000003656 anti-hair-loss Effects 0.000 description 4
- 239000000356 contaminant Substances 0.000 description 4
- 239000012531 culture fluid Substances 0.000 description 4
- 238000000386 microscopy Methods 0.000 description 4
- 231100000957 no side effect Toxicity 0.000 description 4
- 229920001155 polypropylene Polymers 0.000 description 4
- 239000011780 sodium chloride Substances 0.000 description 4
- 230000003068 static effect Effects 0.000 description 4
- 230000001954 sterilising effect Effects 0.000 description 4
- 238000004659 sterilization and disinfection Methods 0.000 description 4
- 239000006228 supernatant Substances 0.000 description 4
- 238000002834 transmittance Methods 0.000 description 4
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 description 4
- 239000000126 substance Substances 0.000 description 3
- 201000004384 Alopecia Diseases 0.000 description 2
- 241000208340 Araliaceae Species 0.000 description 2
- 201000004624 Dermatitis Diseases 0.000 description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 2
- 229920002683 Glycosaminoglycan Polymers 0.000 description 2
- 241001465754 Metazoa Species 0.000 description 2
- 235000005035 Panax pseudoginseng ssp. pseudoginseng Nutrition 0.000 description 2
- 235000003140 Panax quinquefolius Nutrition 0.000 description 2
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 229910000019 calcium carbonate Inorganic materials 0.000 description 2
- 230000007797 corrosion Effects 0.000 description 2
- 238000005260 corrosion Methods 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
- 229910000397 disodium phosphate Inorganic materials 0.000 description 2
- 235000019800 disodium phosphate Nutrition 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 235000008434 ginseng Nutrition 0.000 description 2
- 239000008103 glucose Substances 0.000 description 2
- 239000001963 growth medium Substances 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- WRUGWIBCXHJTDG-UHFFFAOYSA-L magnesium sulfate heptahydrate Chemical compound O.O.O.O.O.O.O.[Mg+2].[O-]S([O-])(=O)=O WRUGWIBCXHJTDG-UHFFFAOYSA-L 0.000 description 2
- 229940061634 magnesium sulfate heptahydrate Drugs 0.000 description 2
- 235000007079 manganese sulphate Nutrition 0.000 description 2
- BZDIAFGKSAYYFC-UHFFFAOYSA-N manganese;hydrate Chemical compound O.[Mn] BZDIAFGKSAYYFC-UHFFFAOYSA-N 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 229910000402 monopotassium phosphate Inorganic materials 0.000 description 2
- 235000019796 monopotassium phosphate Nutrition 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 2
- 238000000247 postprecipitation Methods 0.000 description 2
- 239000000843 powder Substances 0.000 description 2
- 239000002244 precipitate Substances 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 238000005070 sampling Methods 0.000 description 2
- 210000004761 scalp Anatomy 0.000 description 2
- 238000012216 screening Methods 0.000 description 2
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- 239000002699 waste material Substances 0.000 description 2
- 239000011592 zinc chloride Substances 0.000 description 2
- 235000005074 zinc chloride Nutrition 0.000 description 2
- SQDAZGGFXASXDW-UHFFFAOYSA-N 5-bromo-2-(trifluoromethoxy)pyridine Chemical compound FC(F)(F)OC1=CC=C(Br)C=N1 SQDAZGGFXASXDW-UHFFFAOYSA-N 0.000 description 1
- 229920001287 Chondroitin sulfate Polymers 0.000 description 1
- DUKURNFHYQXCJG-UHFFFAOYSA-N Lewis A pentasaccharide Natural products OC1C(O)C(O)C(C)OC1OC1C(OC2C(C(O)C(O)C(CO)O2)O)C(NC(C)=O)C(OC2C(C(OC3C(OC(O)C(O)C3O)CO)OC(CO)C2O)O)OC1CO DUKURNFHYQXCJG-UHFFFAOYSA-N 0.000 description 1
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
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- 239000002253 acid Substances 0.000 description 1
- 229910052785 arsenic Inorganic materials 0.000 description 1
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- 230000007547 defect Effects 0.000 description 1
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- Cosmetics (AREA)
Abstract
The invention discloses anti-allergy conditioning shampoo. The anti-allergy conditioning shampoo is low in hyaluronic acid content and protein content and high in glucuronic acid content, and is prone to dissolve, and good in moisturizing effect; the prepared hyaluronic acid-containing shampoo is good in stability, excellent in decontamination effect, free from toxic and side effects, and mild and non-irritating to skin; while being used for washing hair, the anti-allergy conditioning shampoo has excellent moistening hair care effect, protects the hair against damage and has extremely high safety. The shampoo contains a traditional Chinese medicine extract, and thus is capable of removing dirt on the hair of people and also capable of straightening and smoothing the hair and removing dandruff; the shampoo is also capable of preventing hair loss and increasing and blackening the hair if being used for a long time.
Description
Technical field
The present invention relates to biological polyoses extraction and application technical field, particularly relate to a kind of antiallergic conditioning shampoo.
Background technology
Hair shampoo article is indispensable requisites in people's daily life, can from hair and scalp, remove surperficial greasy dirt and scurf, and hair, scalp and health of human body are had no adverse effects when use.In recent years, due to the raising of people's quality of the life, increasing of hair washing number of times, has also proposed increasing requirement to hair shampoo article.Existing shampoo function singleness, shampoo, in wash clean hair, also likely can cause negative effect to a certain degree to hair, affects hair quality, makes the nutrition leak of hair, causes hair crude, does not possess the function of hair conditioning when hair washing.Need now hair shampoo article to there is the anti-dandruff effect of good decontamination, need again it to there is good abnormal smells from the patient, also need to keep the gloss of hair quality simultaneously, play the nursing role to hair.And be an importance that plays nursing role to the moistening effect of hair.
One-tenth branch in existing hair shampoo article causes part population skin allergy, the symptoms such as dermatitis occurs, human body skin is caused damage, and now on market, the undue hair of most hair washing product is submissive, glittering and in shampoo, added the medicament of injury hair hair quality chemical composition.If the medicament shampoo of life-time service injury hair hair quality chemical composition, can cause health to cause great hidden danger to hair hair quality, therefore the composition in hair shampoo article needs careful selection.
Hyaluronic acid, referred to as HA, is by β-(1 → 3) and acid mucopolysaccharide that β-(1 → 4) glycosidic bond is formed by connecting by glucuronic acid and acetylglucosamine.It has the advantageous properties such as humectant, viscoelasticity and biocompatibility, especially has unique performance of keeping humidity, has been widely used at present the fields such as medicine, daily use chemicals, food, is one of domestic and international biochemical industry circle focus product.
Domestic have tens hyaluronic manufacturers at present, and these enterprise's great majority are to use animal tissue's extraction method.But because raw material is limited, and the content of HA is low in raw material, simultaneously HA also coexists in biological tissue with the mucopolysaccharide such as chondroitin sulfate again, causes that its yield is low, purify difficulty, high cost, poor product quality, and is difficult to be applied to large-scale production.Along with the continuous increase of HA demand, a large amount of high-quality HA is produced in an urgent demand, and oneself can not adapt to this requirement animal tissue's extraction method.The technique fermentation period that also has at present Production by Microorganism Fermentation hyaluronic acid to adopt is long, product relative molecular weight is low, product printing opacity rate variance, protein content is high, glucuronic acid content is low.The hyaluronic form having is fibrous, not soluble.Be difficult to reach the standard that is applied to cosmetic field.
Summary of the invention
Object of the present invention is exactly to provide a kind of antiallergic conditioning shampoo for the defect of above-mentioned existence.Hyaluronic acid yield of the present invention is high, light transmittance good; protein content is low, and glucuronic acid content is high, soluble; moistening effect is good; preparation contain hyaluronic shampoo good stability, clean effect is good, has no side effect; non-stimulated to skin gentleness; when hair washing, have good moisturizing hair care effect, protection hair is injury-free, has very high safety.In shampoo of the present invention, contain Chinese medicine extract and not only realized people and remove the dirt on hair, and straight smooth, the anti-dandruff function of hair, life-time service can play Anti-hair loss, makes hair hypertrophy increase black function.
A kind of antiallergic conditioning shampoo technical scheme of the present invention is, this shampoo contains hyaluronic acid and Chinese medicine extract, described hyaluronic acid adopt streptococcus zooepidemicus (
streptococcus zooepidemicus) the AWA008 preparation of fermenting, streptococcus zooepidemicus (
streptococcus zooepidemicus) AWA008 is in the center preservation of China Committee for Culture Collection of Microorganisms's common micro-organisms, deposit number is: CGMCCNo.9111, preservation date is on 04 29th, 2014.
At present this streptococcus zooepidemicus is in the center preservation of China Committee for Culture Collection of Microorganisms's common micro-organisms, address: No. 3, Yard 1, BeiChen xi Road, Chaoyang District, Beijing City, and postcode: 100101, its deposit number is: CGMCCNo.9111, the Latin title of strain is
streptococcus zooepidemicus, the microorganism (strain) of ginseng certificate: AWA008, preservation date is on 04 29th, 2014.
Streptococcus zooepidemicus strain characteristics of the present invention: spherical in shape or oval, be catenation, there is pod membrane, without spore, atrichia, Gram-positive.
Described Chinese medicine extract is formed by following Chinese drug preparation: Folium Artemisiae Argyi, Radix Polygoni Multiflori, Fructus Gleditsia, Fructus Lycii, Aloe, Flos Caryophylli, Radix Angelicae Sinensis, Flos Chrysanthemi, Cortex Phellodendri.
Described Chinese medicine extract is formed by following Chinese drug preparation by weight: Folium Artemisiae Argyi 8-10 part, Radix Polygoni Multiflori 10-12 part, Fructus Gleditsia 8-15 part, Fructus Lycii 5-10 part, Aloe 5-10 part, Flos Caryophylli 5-10 part, Radix Angelicae Sinensis 6-10 part, Flos Chrysanthemi 5-8 part, Cortex Phellodendri 3-5 part.
Preferably, described Chinese medicine extract is formed by following Chinese drug preparation by weight: 8 parts of Folium Artemisiae Argyis, 12 parts of Radix Polygoni Multiflori, 15 parts of Fructus Gleditsia, 10 parts of Fructus Lycii, 8 parts of Aloes, 6 parts of Flos Caryophyllis, 6 parts of Radix Angelicae Sinensis, 6 parts of Flos Chrysanthemis, 4 parts of Cortex Phellodendris.
The preparation process of described Chinese medicine extract is: take by weight respectively Chinese medicine and pulverize, taking water-ethanol as extracting solvent, heating and refluxing extraction three times, each two hours, merge extractive liquid,, discard medicinal residues, extracting solution is through concentration and recovery ethanol, and transpiring moisture obtains Chinese medicine extract after adopting spraying dry.
Described a kind of antiallergic conditioning shampoo, contain following composition by weight: trisodium citrate 0.2-0.8%, lauric acid 10-20%, hyaluronic acid 0.5-5%, Chinese medicine extract 0.3-2%, methyl butex 0.05-0.2%, dipropylene glycol 1-10%, potassium sorbate 0.1-0.5%, disodiumedetate 0.1-0.5%, essence 0.05-0.2%, surplus is deionized water.
Described a kind of antiallergic conditioning shampoo, further, contain following composition by weight: trisodium citrate 0.3-0.5%, lauric acid 15-20%, hyaluronic acid 1-3%, Chinese medicine extract 0.5-1.5%, methyl butex 0.1-0.2%, dipropylene glycol 1-5%, potassium sorbate 0.1-0.3%, disodiumedetate 0.1-0.3%, essence 0.05-0.1%, surplus is deionized water.
Described a kind of antiallergic conditioning shampoo, preferably, contain following composition by weight: trisodium citrate 0.5%, lauric acid 20%, hyaluronic acid 2%, Chinese medicine extract 1.2%, methyl butex 0.2%, dipropylene glycol 5%, potassium sorbate 0.2%, disodiumedetate 0.3%, essence 0.05%, surplus is deionized water.
Described hyaluronic acid adopts streptococcus zooepidemicus fermentation preparation to comprise the following steps:
(1) shake-flask seed liquid is cultivated: slant strains is inoculated in the 1L conical flask that sterile medium is housed, cultivates 12-16 hour for 37 DEG C, it is good that microscopy is observed thalli growth, without living contaminants, can be inoculated in seed tank;
(2) strain expansion is joined: culture fluid is joined in seed tank, carry out after steam sterilization, 36.3 DEG C of design temperatures, pH6.86, in seed tank, add strain by aseptic requirement, maintain tank pressure 0.05MPa, cultivate 12-16 hour, it is good that microscopy is observed thalli growth, without living contaminants, can be inoculated in fermentation tank;
(3) fermentation: half fermentation culture is joined in fermentation tank, carry out after steam sterilization, 36.3 DEG C of design temperatures, pH6.86, maintain tank pressure 0.05MP, and the culture medium of seed tank is all pressed in fermentation tank, record pH value, in the time that pH declines, add second half fermentation culture, keep indices, fermentation liquid pH fall per minute is less than at 0.01 o'clock and finishes fermentation, detect fermentation broth viscosity, fermentation liquid is pressed in settling tank;
(4) front precipitation: to the ethanol that gently adds 95% in settling tank under stirring state, to producing flakes precipitation, be controlled at 47-50 degree (folding to 20 DEG C time alcoholic strength), collecting precipitation thing;
(5) dissolve: precipitate is dissolved with sodium chloride solution, regulate pH to 9.3-9.5, add EDTA, active carbon, perlite, stir;
(6) filter: the feed liquid after dissolving is pressed into after the large plate-and-frame filtration of 1# one time, and filtrate is adjusted pH9.3-9.5.Add again after white kieselguhr and perlite, after stirring, be pressed into the large plate-and-frame filtration of 2# second time.In two times filtrate, add kieselguhr, after stirring, feed liquid is beaten after circular clarifying by corrosion resistant plate, filters the 3rd time, and clarity is more than 99.5%, and then filtrate passes through polypropylene filter element filtering to clean room settling tank;
(7) postprecipitation: feed liquid is adjusted pH to 7.0-7.3, gently adds 95% ethanol to precipitation to produce under stirring, control ethanol number of degrees 47-50 degree.After static 20-40 minute, supernatant is squeezed into waste alcohol tank;
(8) dewater centrifugal: the dehydration of alcohol with the pH value of 75%-80% between 7.0-7.3 6-7 time, and then with 90% dehydration of alcohol 2-3 time, the alcoholic strength afterwards that dewaters is counted to more than 90%, static about 1 hour, beat supernatant, pH value is surveyed in sampling, and is controlled between 7.0-7.3.Stir centrifugal after 15-20 minute;
(9) dry: centrifugal good material is put into drying chamber, 30 DEG C of design temperatures, evacuation is dry after 3 hours, and 5 DEG C of intensifications per hour stop while establishing warm 60 DEG C, detect moisture, after moisture is less than 7%, go out tank.
Culture fluid in step (1), (2), (3) comprises glucose 3-5%, yeast powder 1.5-2%, Magnesium sulfate heptahydrate 1-2%, four water manganese sulfate 0.01-0.1%, potassium dihydrogen phosphate 0.1-0.5%, sodium hydrogen phosphate 0.5-0.8%, calcium carbonate 0.1-1%, zinc chloride 0.05-0.1% by weight percentage, and surplus is water.
Step 2. concentration of sodium chloride solution is 1-5%.
Step 2. in, add EDTA, active carbon, perlite mass ratio to be, 1:10-15:20-30.
Preferably, add EDTA, active carbon, perlite mass ratio to be, 1:11:25.
Step 3. in, white kieselguhr and perlitic mass ratio are 1:1-10.
Preferably, white kieselguhr and perlitic mass ratio are 1:1.5.
In step (6), filtrate passes through 0.22 micron of polypropylene filter element filtering to clean room settling tank.
Beneficial effect of the present invention is: hyaluronic acid yield of the present invention is high, light transmittance good; protein content is low, and glucuronic acid content is high, soluble; moistening effect is good; preparation contain hyaluronic shampoo good stability, clean effect is good, has no side effect; non-stimulated to skin gentleness; when hair washing, have good moisturizing hair care effect, protection hair is injury-free, has very high safety.In shampoo of the present invention, contain Chinese medicine extract and not only realized people and remove the dirt on hair, and straight smooth, the anti-dandruff function of hair, life-time service can play Anti-hair loss, makes hair hypertrophy increase black function.
The present invention adopts complex mutation technology screening to go out the strain that hyaluronic acid productivity is high, combining with fermentation technology, and hyaluronic acid product output capacity is high, can reach 7-9g/L.The hyaluronic acid that fermentation obtains is easy to separation and purification, with short production cycle.Adopt add active carbon, perlite, white kieselguhr, EDTA removes the impurity in hyaluronic acid in conjunction with large plate-and-frame filtration technology, additive is common to be easy to get, and operates relatively simply, impurity content is lower.Use 75-80% ethanol to carry out 6-7 dehydration to material, 90% ethanol carries out 2-3 dehydration to material.So progressively dehydration has not only reduced the moisture in hyaluronic acid, is easy to be dried, and has washed away a small amount of impurity residual in material, and protein content is lower, and product purity is high.Use ethanol repeatedly to dewater to reach 90% when above after, can obtain Powdered amorphous precipitatedly, it is dry that product dissolubility is good afterwards, bulk density is moderate.Hyaluronic acid product quality meets the standard of cosmetic field.
detailed description of the invention:
In order to understand better the present invention, describe technical scheme of the present invention in detail with instantiation below, but the present invention is not limited thereto.
Embodiment 1
A kind of antiallergic conditioning shampoo technical scheme of the present invention is, a kind of streptococcus zooepidemicus (
streptococcus zooepidemicus) AWA008, it is in the center preservation of China Committee for Culture Collection of Microorganisms's common micro-organisms, and its deposit number is: CGMCCNo.9111, preservation date is on 04 29th, 2014.
At present this streptococcus zooepidemicus is in the center preservation of China Committee for Culture Collection of Microorganisms's common micro-organisms, address: No. 3, Yard 1, BeiChen xi Road, Chaoyang District, Beijing City, and postcode: 100101, its deposit number is: CGMCCNo.9111, the Latin title of strain is
streptococcus zooepidemicus, the microorganism (strain) of ginseng certificate: AWA008, preservation date is on 04 29th, 2014.
Streptococcus zooepidemicus strain characteristics of the present invention: spherical in shape or oval, be catenation, there is pod membrane, without spore, atrichia, Gram-positive.
Described streptococcus zooepidemicus is prepared hyaluronic production technology, comprises the following steps:
(1) shake-flask seed liquid is cultivated: slant strains is inoculated in the 1L conical flask that sterile medium is housed, cultivates 12-16 hour for 37 DEG C, it is good that microscopy is observed thalli growth, without living contaminants, can be inoculated in seed tank;
(2) strain expansion is joined: culture fluid is joined in seed tank, carry out after steam sterilization, 36.3 DEG C of design temperatures, pH6.86, in seed tank, add strain by aseptic requirement, maintain tank pressure 0.05MPa, cultivate 12-16 hour, it is good that microscopy is observed thalli growth, without living contaminants, can be inoculated in fermentation tank;
(3) fermentation: half fermentation culture is joined in fermentation tank, carry out after steam sterilization, 36.3 DEG C of design temperatures, pH6.86, maintain tank pressure 0.05MP, and the culture medium of seed tank is all pressed in fermentation tank, record pH value, in the time that pH declines, add second half fermentation culture, keep indices, fermentation liquid pH fall per minute is less than at 0.01 o'clock and finishes fermentation, detect fermentation broth viscosity, fermentation liquid is pressed in settling tank;
(4) front precipitation: to the ethanol that gently adds 95% in settling tank under stirring state, to producing flakes precipitation, be controlled at 47-50 degree (folding to 20 DEG C time alcoholic strength), collecting precipitation thing;
(5) dissolve: precipitate is dissolved with sodium chloride solution, regulate pH to 9.3-9.5, add EDTA, active carbon, perlite, stir;
(6) filter: the feed liquid after dissolving is pressed into after the large plate-and-frame filtration of 1# one time, and filtrate is adjusted pH9.3-9.5.Add again after white kieselguhr and perlite, after stirring, be pressed into the large plate-and-frame filtration of 2# second time.In two times filtrate, add kieselguhr, after stirring, feed liquid is beaten after circular clarifying by corrosion resistant plate, filters the 3rd time, and clarity is more than 99.5%, and then filtrate passes through polypropylene filter element filtering to clean room settling tank;
(7) postprecipitation: feed liquid is adjusted pH to 7.0-7.3, gently adds 95% ethanol to precipitation to produce under stirring, control ethanol number of degrees 47-50 degree.After static 20-40 minute, supernatant is squeezed into waste alcohol tank;
(8) dewater centrifugal: the dehydration of alcohol with the pH value of 75%-80% between 7.0-7.3 6-7 time, and then with 90% dehydration of alcohol 2-3 time, the alcoholic strength afterwards that dewaters is counted to more than 90%, static about 1 hour, beat supernatant, pH value is surveyed in sampling, and is controlled between 7.0-7.3.Stir centrifugal after 15-20 minute;
(9) dry: centrifugal good material is put into drying chamber, 30 DEG C of design temperatures, evacuation is dry after 3 hours, and 5 DEG C of intensifications per hour stop while establishing warm 60 DEG C, detect moisture, after moisture is less than 7%, go out tank.
Culture fluid in step (1), (2), (3) comprises glucose 3%, yeast powder 1.5%, Magnesium sulfate heptahydrate 1%, four water manganese sulfates 0.05%, potassium dihydrogen phosphate 0.3%, sodium hydrogen phosphate 0.8%, calcium carbonate 0.2%, zinc chloride 0.08% by weight percentage, and surplus is water.
Step (5) concentration of sodium chloride solution is 3%.
In step (5), add EDTA, active carbon, perlite mass ratio to be, 1:11:25.
In step (6), white kieselguhr and perlitic mass ratio are 1:1.5.
In step (6), filtrate passes through 0.22 micron of polypropylene filter element filtering to clean room settling tank.
1. the present invention adopts complex mutation technology screening to go out the strain that hyaluronic acid productivity is high, combining with fermentation technology, and hyaluronic acid product productive rate reaches 9g/L.The hyaluronic acid that fermentation obtains is easy to separation and purification, with short production cycle.
2. the present invention adopts and adds active carbon, perlite, white kieselguhr, EDTA in conjunction with the impurity in large plate-and-frame filtration technology removal hyaluronic acid, additive is common to be easy to get, operate relatively simple, impurity content lower (protein≤0.1%, heavy metal≤20ppm, arsenic salt≤2ppm).
3. the present invention uses 75-80% ethanol to carry out 6-7 dehydration to material, and 90% ethanol carries out 2-3 dehydration to material.So progressively dehydration has not only reduced the moisture in hyaluronic acid, is easy to be dried, and has washed away a small amount of impurity residual in material, and protein content is lower, and product purity is high, can reach more than 99.0%.
The present invention use ethanol repeatedly to dewater to reach 90% when above after, can obtain Powdered amorphous precipitated, dry after product dissolubility good, dissolution velocity is fast, degraded is slow, bulk density moderate (bulk density 0.4～0.6g/ml).
5. production technology of the present invention is simple, and supplementary material is common to be easy to get, and produces and is easy to control, and impurity content is lower, is applicable to large-scale industrialization and produces, and yield is high, and greatly reduces production cost.
Embodiment 2
A kind of antiallergic conditioning shampoo of the present invention, contains hyaluronic acid and Chinese medicine extract, described hyaluronic acid employing streptococcus zooepidemicus (
streptococcus zooepidemicus) the AWA008 preparation of fermenting, streptococcus zooepidemicus (
streptococcus zooepidemicus) AWA008 is in the center preservation of China Committee for Culture Collection of Microorganisms's common micro-organisms, deposit number is: CGMCCNo.9111, preservation date is on 04 29th, 2014.
Described Chinese medicine extract is formed by following Chinese drug preparation by weight: 8 parts of Folium Artemisiae Argyis, 12 parts of Radix Polygoni Multiflori, 15 parts of Fructus Gleditsia, 10 parts of Fructus Lycii, 8 parts of Aloes, 6 parts of Flos Caryophyllis, 6 parts of Radix Angelicae Sinensis, 6 parts of Flos Chrysanthemis, 4 parts of Cortex Phellodendris.
The preparation process of described Chinese medicine extract is: take by weight respectively Chinese medicine and pulverize, taking water-ethanol as extracting solvent, heating and refluxing extraction three times, each two hours, merge extractive liquid,, discard medicinal residues, extracting solution is through concentration and recovery ethanol, and transpiring moisture obtains Chinese medicine extract after adopting spraying dry.
A kind of antiallergic conditioning shampoo, contain following composition by weight: trisodium citrate 0.5%, lauric acid 20%, hyaluronic acid 2%, Chinese medicine extract 1.2%, methyl butex 0.2%, dipropylene glycol 5%, potassium sorbate 0.2%, disodiumedetate 0.3%, essence 0.05%, surplus is deionized water.
Hyaluronic acid yield of the present invention is high, light transmittance good; protein content is low, and glucuronic acid content is high, soluble; moistening effect is good; preparation contain hyaluronic shampoo good stability, clean effect is good, has no side effect; non-stimulated to skin gentleness; when hair washing, have good moisturizing hair care effect, protection hair is injury-free, has very high safety.In shampoo of the present invention, contain Chinese medicine extract and not only realized people and remove the dirt on hair, and straight smooth, the anti-dandruff function of hair, life-time service can play Anti-hair loss, makes hair hypertrophy increase black function.
Embodiment 3
A kind of antiallergic conditioning shampoo of the present invention contains hyaluronic acid and Chinese medicine extract, described hyaluronic acid employing streptococcus zooepidemicus (
streptococcus zooepidemicus) the AWA008 preparation of fermenting, streptococcus zooepidemicus (
streptococcus zooepidemicus) AWA008 is in the center preservation of China Committee for Culture Collection of Microorganisms's common micro-organisms, deposit number is: CGMCCNo.9111, preservation date is on 04 29th, 2014.
Described Chinese medicine extract is formed by following Chinese drug preparation by weight: 8 parts of Folium Artemisiae Argyis, 10 parts of Radix Polygoni Multiflori, 8 parts of Fructus Gleditsia, 10 parts of Fructus Lycii, 5 parts of Aloes, 5 parts of Flos Caryophyllis, 10 parts of Radix Angelicae Sinensis, 8 parts of Flos Chrysanthemis, 5 parts of Cortex Phellodendris.
The preparation process of described Chinese medicine extract is: take by weight respectively Chinese medicine and pulverize, taking water-ethanol as extracting solvent, heating and refluxing extraction three times, each two hours, merge extractive liquid,, discard medicinal residues, extracting solution is through concentration and recovery ethanol, and transpiring moisture obtains Chinese medicine extract after adopting spraying dry.
A kind of antiallergic conditioning shampoo, contain following composition by weight: trisodium citrate 0.3%, lauric acid 15%, hyaluronic acid 3%, Chinese medicine extract 1.5%, methyl butex 0.1%, dipropylene glycol 2%, potassium sorbate 0.1%, disodiumedetate 0.1%, essence 0.05%, surplus is deionized water.
Hyaluronic acid yield of the present invention is high, light transmittance good; protein content is low, and glucuronic acid content is high, soluble; moistening effect is good; preparation contain hyaluronic shampoo good stability, clean effect is good, has no side effect; non-stimulated to skin gentleness; when hair washing, have good moisturizing hair care effect, protection hair is injury-free, has very high safety.In shampoo of the present invention, contain Chinese medicine extract and not only realized people and remove the dirt on hair, and straight smooth, the anti-dandruff function of hair, life-time service can play Anti-hair loss, makes hair hypertrophy increase black function.
Claims (8)
1. an antiallergic conditioning shampoo, is characterized in that, this shampoo contains hyaluronic acid and Chinese medicine extract, described hyaluronic acid employing streptococcus zooepidemicus (
streptococcus zooepidemicus) the AWA008 preparation of fermenting, streptococcus zooepidemicus (
streptococcus zooepidemicus) AWA008 deposit number is: CGMCCNo.9111, preservation date is on 04 29th, 2014.
2. a kind of antiallergic conditioning shampoo according to claim 1, is characterized in that, described Chinese medicine extract is formed by following Chinese drug preparation: Folium Artemisiae Argyi, Radix Polygoni Multiflori, Fructus Gleditsia, Fructus Lycii, Aloe, Flos Caryophylli, Radix Angelicae Sinensis, Flos Chrysanthemi, Cortex Phellodendri.
3. a kind of antiallergic conditioning shampoo according to claim 2, it is characterized in that, described Chinese medicine extract is formed by following Chinese drug preparation by weight: Folium Artemisiae Argyi 8-10 part, Radix Polygoni Multiflori 10-12 part, Fructus Gleditsia 8-15 part, Fructus Lycii 5-10 part, Aloe 5-10 part, Flos Caryophylli 5-10 part, Radix Angelicae Sinensis 6-10 part, Flos Chrysanthemi 5-8 part, Cortex Phellodendri 3-5 part.
4. a kind of antiallergic conditioning shampoo according to claim 2, is characterized in that, described Chinese medicine extract is formed by following Chinese drug preparation by weight: 8 parts of Folium Artemisiae Argyis, 12 parts of Radix Polygoni Multiflori, 15 parts of Fructus Gleditsia, 10 parts of Fructus Lycii, 8 parts of Aloes, 6 parts of Flos Caryophyllis, 6 parts of Radix Angelicae Sinensis, 6 parts of Flos Chrysanthemis, 4 parts of Cortex Phellodendris.
5. a kind of antiallergic conditioning shampoo according to claim 2, it is characterized in that, the preparation process of described Chinese medicine extract is: take by weight respectively Chinese medicine and pulverize, taking water-ethanol as extracting solvent, heating and refluxing extraction three times, each two hours, merge extractive liquid,, discard medicinal residues, extracting solution is through concentration and recovery ethanol, and transpiring moisture obtains Chinese medicine extract after adopting spraying dry.
6. a kind of antiallergic conditioning shampoo according to claim 1, it is characterized in that, contain following composition by weight: trisodium citrate 0.2-0.8%, lauric acid 10-20%, hyaluronic acid 0.5-5%, Chinese medicine extract 0.3-2%, methyl butex 0.05-0.2%, dipropylene glycol 1-10%, potassium sorbate 0.1-0.5%, disodiumedetate 0.1-0.5%, essence 0.05-0.2%, surplus is deionized water.
7. a kind of antiallergic conditioning shampoo according to claim 1, it is characterized in that, contain following composition by weight: trisodium citrate 0.3-0.5%, lauric acid 15-20%, hyaluronic acid 1-3%, Chinese medicine extract 0.5-1.5%, methyl butex 0.1-0.2%, dipropylene glycol 1-5%, potassium sorbate 0.1-0.3%, disodiumedetate 0.1-0.3%, essence 0.05-0.1%, surplus is deionized water.
8. a kind of antiallergic conditioning shampoo according to claim 1, it is characterized in that, contain following composition by weight: trisodium citrate 0.5%, lauric acid 20%, hyaluronic acid 2%, Chinese medicine extract 1.2%, methyl butex 0.2%, dipropylene glycol 5%, potassium sorbate 0.2%, disodiumedetate 0.3%, essence 0.05%, surplus is deionized water.
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| CN105232404A (en) * | 2015-11-11 | 2016-01-13 | 曹涛 | Liquid shampoo for repairing damaged scalp after hair dyeing and hair perming and removing scrap and resisting to allergy |
| CN115397458A (en) * | 2020-02-25 | 2022-11-25 | 安普力菲卡公司 | Compositions and methods for stimulating hair growth |
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| CN115397458A (en) * | 2020-02-25 | 2022-11-25 | 安普力菲卡公司 | Compositions and methods for stimulating hair growth |
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