CN104173635A - Drug for treating acnes and preparation method of drug - Google Patents
Drug for treating acnes and preparation method of drug Download PDFInfo
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- CN104173635A CN104173635A CN201410460072.4A CN201410460072A CN104173635A CN 104173635 A CN104173635 A CN 104173635A CN 201410460072 A CN201410460072 A CN 201410460072A CN 104173635 A CN104173635 A CN 104173635A
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- 239000003814 drug Substances 0.000 title claims abstract description 42
- 238000002360 preparation method Methods 0.000 title claims abstract description 33
- 229940079593 drug Drugs 0.000 title abstract description 10
- 208000020154 Acnes Diseases 0.000 title abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 48
- 241001506047 Tremella Species 0.000 claims abstract description 45
- NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 claims abstract description 38
- NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 claims abstract description 38
- 229940041616 menthol Drugs 0.000 claims abstract description 38
- 241001116389 Aloe Species 0.000 claims abstract description 37
- 235000011399 aloe vera Nutrition 0.000 claims abstract description 37
- 206010000496 acne Diseases 0.000 claims abstract description 33
- 208000002874 Acne Vulgaris Diseases 0.000 claims abstract description 32
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 30
- 239000008367 deionised water Substances 0.000 claims abstract description 18
- 229910021641 deionized water Inorganic materials 0.000 claims abstract description 18
- 238000000034 method Methods 0.000 claims abstract description 8
- 230000008569 process Effects 0.000 claims abstract description 5
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 39
- 241000195474 Sargassum Species 0.000 claims description 31
- 238000000605 extraction Methods 0.000 claims description 31
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims description 24
- 239000000047 product Substances 0.000 claims description 19
- 229960004756 ethanol Drugs 0.000 claims description 18
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 claims description 12
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 12
- 239000012043 crude product Substances 0.000 claims description 12
- 239000000706 filtrate Substances 0.000 claims description 12
- 238000001556 precipitation Methods 0.000 claims description 12
- 238000003756 stirring Methods 0.000 claims description 12
- 241000561734 Celosia cristata Species 0.000 claims description 11
- 210000001520 comb Anatomy 0.000 claims description 11
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims description 9
- 238000004140 cleaning Methods 0.000 claims description 9
- 239000013078 crystal Substances 0.000 claims description 9
- 239000002244 precipitate Substances 0.000 claims description 9
- 239000000843 powder Substances 0.000 claims description 8
- 238000001914 filtration Methods 0.000 claims description 7
- 239000002994 raw material Substances 0.000 claims description 7
- 239000012153 distilled water Substances 0.000 claims description 6
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 6
- 239000004519 grease Substances 0.000 claims description 6
- 239000011780 sodium chloride Substances 0.000 claims description 6
- 238000010792 warming Methods 0.000 claims description 4
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 3
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 108010059712 Pronase Proteins 0.000 claims description 3
- 238000013019 agitation Methods 0.000 claims description 3
- 230000015556 catabolic process Effects 0.000 claims description 3
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 3
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 3
- 238000005352 clarification Methods 0.000 claims description 3
- 238000001816 cooling Methods 0.000 claims description 3
- 238000006731 degradation reaction Methods 0.000 claims description 3
- 229960000935 dehydrated alcohol Drugs 0.000 claims description 3
- 230000018044 dehydration Effects 0.000 claims description 3
- 238000006297 dehydration reaction Methods 0.000 claims description 3
- 238000004090 dissolution Methods 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 238000004108 freeze drying Methods 0.000 claims description 3
- 230000002070 germicidal effect Effects 0.000 claims description 3
- 238000000227 grinding Methods 0.000 claims description 3
- 229920002674 hyaluronan Polymers 0.000 claims description 3
- 229960003160 hyaluronic acid Drugs 0.000 claims description 3
- 239000007788 liquid Substances 0.000 claims description 3
- 230000003647 oxidation Effects 0.000 claims description 3
- 238000007254 oxidation reaction Methods 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 239000013049 sediment Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 239000007787 solid Substances 0.000 claims description 3
- 238000001256 steam distillation Methods 0.000 claims description 3
- 238000013517 stratification Methods 0.000 claims description 3
- 230000008961 swelling Effects 0.000 claims description 3
- 230000001052 transient effect Effects 0.000 claims description 3
- 238000001291 vacuum drying Methods 0.000 claims description 3
- 238000005406 washing Methods 0.000 claims description 3
- 238000002791 soaking Methods 0.000 claims description 2
- 206010061218 Inflammation Diseases 0.000 abstract description 5
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- 230000008439 repair process Effects 0.000 abstract description 4
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- 229920002385 Sodium hyaluronate Polymers 0.000 abstract 2
- 229940010747 sodium hyaluronate Drugs 0.000 abstract 2
- 235000006679 Mentha X verticillata Nutrition 0.000 abstract 1
- 235000002899 Mentha suaveolens Nutrition 0.000 abstract 1
- 235000001636 Mentha x rotundifolia Nutrition 0.000 abstract 1
- 230000000474 nursing effect Effects 0.000 abstract 1
- 230000001954 sterilising effect Effects 0.000 abstract 1
- 210000003491 skin Anatomy 0.000 description 3
- 241000186427 Cutibacterium acnes Species 0.000 description 2
- MUMGGOZAMZWBJJ-DYKIIFRCSA-N Testostosterone Chemical compound O=C1CC[C@]2(C)[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 MUMGGOZAMZWBJJ-DYKIIFRCSA-N 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- 238000004299 exfoliation Methods 0.000 description 2
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Landscapes
- Cosmetics (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a drug for treating acnes and a preparation method of the drug. The drug is used for solving the problem that the existing technology is poor in later repair of acnes. The drug consists of the following components in percentage by weight: 0.1-2% of mint, 0.05-0.5% of sodium hyaluronate, 0.05-15% of aloe extracting liquor, 0.2-10% of tremella extract, 0.1-3% of alga extract and the balance of deionized water. According to the drug, the menthol, sodium hyaluronate, aloe extracting liquor, tremella extract and alga extract are matched to strengthen sterilizing and inflammation-diminishing effects during an acne treatment process so as to effectively relieve symptoms of inflammation; and moreover, the drug has good repair capacity for enabling the skin to recover. Besides, the drug can be used for comprehensively and effectively nursing acne skin.
Description
Technical field
The present invention relates to medicine of a kind of Acne treatment and preparation method thereof.
Background technology
The factors such as the generation of acne is main stops up with hypersteatosis, pilosebaceous duct, antibacterial infection and inflammatory reaction are closely related.After adolescing in human body androgen particularly the level of testosterone raise rapidly, promote sebaceous gland to grow and produce a large amount of sebums.The dyskeratosis of pilosebaceous duct causes conduit to stop up simultaneously, dyssebacia, and forming horn plug is micropowder thorn.Multiple-microorganism propionibacterium acnes amount reproduction especially in hair follicle, the lipase that propionibacterium acnes produces decomposes sebum and generates free fatty, simultaneously chemotactic inflammatory cell and medium, final induction exacerbate inflammation reaction.
The product of existing Acne treatment on the market, generally with exfoliation, dredge blockage pore, or the oils and fats absorbing in pore by physical action is main, the later stage of acne is repaired and ignored to some extent, and the product of life-time service exfoliation can cause keratodermatitis attenuation, responsive to environmental stimulus, easily produce the symptoms such as irritated.
Summary of the invention
The object of the present invention is to provide medicine of a kind of Acne treatment and preparation method thereof, solve the problem of prior art to acne later stage repair ability deficiency.
The present invention is achieved through the following technical solutions:
A medicine for Acne treatment, this medicine is comprised of the component of following mass percent:
Menthol 0.1～2%
Hyaluronate sodium 0.05～0.5%
Aloe extraction solution 0.05～15%
Tremella extract 0.2～10%
Sargassum extract 0.1～3%;
Surplus is mended to 100% with deionized water.
As a kind of selection, this medicine is comprised of the component of following mass percent: menthol 0.5%, hyaluronate sodium 0.5%, Aloe extraction solution 8.4%, Tremella extract 4.5%, Sargassum extract 1.5%, deionized water 84.6%.
As another kind, select, this medicine is comprised of the component of following mass percent: menthol 0.1%, hyaluronate sodium 0.06%, Aloe extraction solution 5.0%, Tremella extract 2.5%, Sargassum extract 1.0%, deionized water 91.34%.
As another kind, select, this medicine is comprised of the component of following mass percent: menthol 1%, hyaluronate sodium 0.2%, Aloe extraction solution 11%, Tremella extract 8%, Sargassum extract 3%, deionized water 76.8%.
A preparation method for the medicine of Acne treatment, comprises the following steps:
1) take menthol, hyaluronate sodium, Aloe extraction solution, Tremella extract and Sargassum extract;
2) deionized water is added in reactor, be heated to 35～45 ℃, add hyaluronate sodium, continue to be warming up to 50～65 ℃, be incubated 20～40 minutes;
3) add successively respectively menthol, Aloe extraction solution, Tremella extract, Sargassum extract after being cooled to 35～45 ℃;
4) after raw material adds, under the condition of 35～45 ℃, be incubated 10～20 minutes, be then cooled to 20 ℃, obtain product.
Further, the preparation method of menthol is as follows:
(1) get Herba Menthae herb, with steam distillation, obtain Oleum menthae;
(2) by Oleum menthae in 0～5 ℃ of cold putting, filter, obtain menthol crystal and grease;
(3) by grease frequent pressure fractionating again, collect 202～212 ℃ of fractions, and by it in 0～5 ℃ of cold putting, separate out menthol crystal;
(4) collect all menthol crystal, be dried, obtain menthol finished product.
Again further, the preparation method of hyaluronate sodium is as follows:
(1) cockscomb fragment is joined in acetone, be dipped to hat dehydration hardening, then dry, pulverize to obtain cockscomb powder; Cockscomb powder is poured in container, and added distilled water, stir, more than soaking 24h, make the abundant swelling of cockscomb powder, then filter, collect filtrate, filtering residue soaks 3 times by preceding method again, merges the filtrate of 3 times;
(2) filtrate is poured in container, under agitation add solid oxidation sodium, and add chloroform, stir after 3h, separate water; In the water separating, add ethanol, stir, standing over night, is settled out hyaluronic acid, is then filtered dry precipitate, is drying to obtain crude product;
(3) crude product is dissolved in sodium chloride solution, regulates pH to 4.5～5, then add chloroform with dilute hydrochloric acid, after stratification, sucking-off upper strata water, regulates water pH to 7.5 with sodium hydroxide solution, adds pronase, under the condition of 37 ℃, is incubated 24 hours;
(4) with chloroform extraction, process twice, merge upper strata water, lower floor's liquids recovery chloroform, then in water, add cetylpyridinium chloride solution, and stir, staticly settle, filter collecting precipitation;
(5) use sodium chloride dissolution precipitation, filter, then add ethanol in filtrate, staticly settle, suck upper strata ethanol, ethanol repeated precipitation twice for lower floor, then lower sediment thing is filtered, dry, finally use washing with acetone twice, vacuum drying, obtains hyaluronate sodium finished product.
Further, the preparation method of Aloe extraction solution is as follows:
(1) with clear water, soak after Folium Aloe, then cleaning blade;
(2) the prune part at blade two ends, is placed on blade in germicidal solution and soaks 10～20 minutes, then drain after cleaning with clear water;
(3) crust of separated aloe leaf and gel, and gel and crust are ground respectively;
(4) deposit after the gel after grinding is degraded by TRANSIENT HIGH TEMPERATURE and make it natural cooling;
(5) juice viscosity after high temperature degradation greatly being reduced carries out coarse filtration, fine straining, removes fiber and precipitate, obtains the juice of clarification, is Aloe extraction solution finished product.
In addition, the preparation method of Tremella extract is as follows:
(1) Tremella is soaked 12～16 hours with water-stop in container, then repeatedly clean repeatedly;
(2) Tremella after cleaning was decocted after 5～7 hours, obtain Tremella extract crude product;
(3) Tremella extract crude product is removed to upper strata offscum, then carry out secondary concentration;
(4) Tremella extract after concentrated is carried out to precipitate with ethanol, precipitate with ethanol, after 12～16 hours, filters, dry, obtains Tremella extract finished product.
In addition, the preparation method of Sargassum extract is as follows:
(1) Sargassum is shredded, add distilled water, in 60 ℃ of water-baths, extract 8 hours, lixiviate 3 times, obtains extracting solution;
(2) extracting solution is concentrated, then add dehydrated alcohol, at 0～10 ℃ standing 12 hours;
(3) centrifugalize, collecting precipitation, lyophilization, obtains Sargassum extract.
The present invention has the following advantages and beneficial effect:
The present invention adopts menthol, hyaluronate sodium, Aloe extraction solution, Tremella extract, Sargassum extract to arrange in pairs or groups mutually, strengthens bactericidal antiphlogistic effect in acne treatment process, the symptom that effectively reduces inflammation, and there is good repair ability, skin is calmed down as before; In addition, the present invention can nurse comprehensively and effectively to acne skin.
The specific embodiment
Below in conjunction with embodiment, the present invention is further illustrated, but embodiments of the present invention are not limited to this.
Embodiment 1
A medicine for Acne treatment, this medicine is comprised of the component of following mass percent: menthol 0.5%, hyaluronate sodium 0.5%, Aloe extraction solution 8.4%, Tremella extract 4.5%, Sargassum extract 1.5%, deionized water 84.6%; Its preparation method is as follows:
1) take menthol, hyaluronate sodium, Aloe extraction solution, Tremella extract and the Sargassum extract of above-mentioned quality;
2) deionized water of above-mentioned quality is entered in reactor, be heated to 35～45 ℃, add hyaluronate sodium, continue to be warming up to 50～65 ℃, be incubated 20～40 minutes;
3) add successively respectively menthol, Aloe extraction solution, Tremella extract, Sargassum extract after being cooled to 35～45 ℃, what every kind of raw material added is spaced apart 3～8 minutes;
4) after raw material adds, under the condition of 35～45 ℃, be incubated 10～20 minutes, be then cooled to 20 ℃, obtain product.
Wherein, the preparation method of menthol is as follows:
(1) get Herba Menthae herb, with steam distillation, obtain Oleum menthae;
(2) by Oleum menthae in 0～5 ℃ of cold putting, filter, obtain menthol crystal and grease;
(3) by grease frequent pressure fractionating again, collect 202～212 ℃ of fractions, and by it in 0～5 ℃ of cold putting, separate out menthol crystal;
(4) collect above-mentioned all menthol crystal that obtains, be dried, obtain menthol finished product.
The preparation method of hyaluronate sodium is as follows:
(1) cockscomb fragment is joined in acetone, soaked overnight, to hat dehydration hardening, is then placed in porcelain dish and is dried, and is dried and is ground into powdery by pulverizer; Cockscomb powder is poured in enamel pot, added 6～7 times of distilled water, stir, soak more than 24 hours, make the abundant swelling of cockscomb powder, then filter, collect filtrate, filtering residue soaks 3 times by aforementioned same method again, merges the filtrate after filtering for 3 times;
(2) above-mentioned filtrate is poured in ceramic cylinder, under agitation add 10% solid oxidation sodium, and add isopyknic chloroform, stir after 3h, separate water; 95% ethanol to adding 2 times of volumes in the water separating, stirs, and standing over night, is settled out hyaluronic acid, is then filtered dry precipitate, is drying to obtain crude product;
(3) crude product is dissolved in again in the 0.1mol/L sodium chloride solution of 4 times of volumes, with dilute hydrochloric acid, regulate pH to 4.5～5, add again isopyknic chloroform, after stratification, sucking-off upper strata water, with 8% sodium hydroxide solution, regulate water pH to 7.5, add pronase, under the condition of 37 ℃, be incubated 24 hours;
(4) with equal-volume chloroform extraction, process 2 times again, merge upper strata water, lower floor's liquids recovery chloroform, then in water, add isopyknic 1% cetylpyridinium chloride solution, and stir, staticly settle, filter collecting precipitation;
(5) with the 0.4mol/L sodium chloride dissolution precipitation of 2～3 times of volumes, filter, in filtrate, add 3 times of volume 95% ethanol again, staticly settle, suck upper strata ethanol, 95% ethanol repeated precipitation 2 times for lower floor, again lower sediment thing is filtered, dry, finally use washing with acetone 2 times, vacuum drying, obtains hyaluronate sodium finished product.
The preparation method of Aloe extraction solution is as follows:
(1) with clear water, soak after Folium Aloe, then clean blade with cleaning machine;
(2) the few part of blade two ends meat of pruning, is placed on blade in germicidal solution and soaks 10～20 minutes, then drains after cleaning with clear water;
(3) use Aloe peeling machine crust and the gel of separated aloe leaf neatly, and gel and crust are ground respectively;
(4) gel after grinding is passed through after TRANSIENT HIGH TEMPERATURE (105～125 ℃, 3～5 minutes) is degraded, deposit and make it natural cooling;
(5) juice viscosity after high temperature degradation greatly being reduced carries out coarse filtration, fine straining, removes fiber and precipitate, obtains the juice of clarification, is Aloe extraction solution finished product.
The preparation method of Tremella extract is as follows:
(1) Tremella is soaked 12～16 hours with water-stop in container, then repeatedly clean 3 times;
(2) Tremella after cleaning is poured in steam still, decocted after 5～7 hours, stop decocting, obtain Tremella extract crude product;
(3) Tremella extract crude product is removed to upper strata offscum, then carry out secondary concentration;
(4) Tremella extract after concentrated is carried out to precipitate with ethanol, precipitate with ethanol, after 12～16 hours, filters, dry, obtains Tremella extract finished product.
The preparation method of Sargassum extract is as follows:
(1) Sargassum is shredded, add the distilled water of 2 times of volumes, in 60 ℃ of water-baths, extract 8 hours, lixiviate 3 times, obtains extracting solution;
(2) extracting solution is concentrated into 1/3 volume, reenters 3.5 times and add dehydrated alcohol, at 0～10 ℃ standing 12 hours;
(3) centrifugalize, collecting precipitation, lyophilization, obtains Sargassum extract.
Embodiment 2
A medicine for Acne treatment, this medicine is comprised of the component of following mass percent: menthol 0.1%, hyaluronate sodium 0.06%, Aloe extraction solution 5.0%, Tremella extract 2.5%, Sargassum extract 1.0%, deionized water 91.34%; Its preparation method is as follows:
1) take menthol, hyaluronate sodium, Aloe extraction solution, Tremella extract and the Sargassum extract of above-mentioned quality;
2) deionized water of above-mentioned quality is entered in reactor, be heated to 35～45 ℃, add hyaluronate sodium, continue to be warming up to 50～65 ℃, be incubated 20～40 minutes;
3) add successively respectively menthol, Aloe extraction solution, Tremella extract, Sargassum extract after being cooled to 35～45 ℃, what every kind of raw material added is spaced apart 3～8 minutes;
4) after raw material adds, under the condition of 35～45 ℃, be incubated 10～20 minutes, be then cooled to 20 ℃, obtain product.
The concrete preparation method of each raw material is identical with embodiment 1.
Embodiment 3
A medicine for Acne treatment, this medicine is comprised of the component of following mass percent: menthol 1%, hyaluronate sodium 0.2%, Aloe extraction solution 11%, Tremella extract 8%, Sargassum extract 3%, deionized water 76.8%; Its preparation method is following identical with embodiment 1.
Embodiment 4
A medicine for Acne treatment, this medicine is comprised of the component of following mass percent: menthol 2%, hyaluronate sodium 0.4%, Aloe extraction solution 5.4%, Tremella extract 6.2%, Sargassum extract 2.1%, deionized water 83.9%; Its preparation method is following identical with embodiment 1.
Embodiment 5
A medicine for Acne treatment, this medicine is comprised of the component of following mass percent: menthol 1.3%, hyaluronate sodium 0.18%, Aloe extraction solution 2.8%, Tremella extract 6.7%, Sargassum extract 1.2%, deionized water 87.82%; Its preparation method is following identical with embodiment 1.
The present invention is application compress, only needs relevant position to film during use again; Clinical trial of the present invention is as follows:
The product that adopts the embodiment of the present invention 1 is used 100 routine patients with acne types such as () blackhead, hoary hair, tuberositys, once a day, through trimestral lasting use, wherein 90 routine patients' patients with acne symptom almost disappears, fully recovered, and skin calms down as before; 5 routine patient's acne symptoms obviously alleviate.By clinical trial, can prove that the present invention has good curative effect to acne.
Should be noted that, above embodiment is the unrestricted technical scheme of the present invention in order to explanation only, although the present invention is had been described in detail with reference to above-described embodiment, those of ordinary skill in the art is to be understood that: still can modify or be equal to replacement the present invention, and not departing from any modification or partial replacement of the spirit and scope of the present invention, it all should be encompassed in claim scope of the present invention.
Claims (10)
1. a medicine for Acne treatment, is characterized in that, this medicine is comprised of the component of following mass percent:
Menthol 0.1～2%
Hyaluronate sodium 0.05～0.5%
Aloe extraction solution 0.05～15%
Tremella extract 0.2～10%
Sargassum extract 0.1～3%;
Surplus is mended to 100% with deionized water.
2. the medicine of a kind of Acne treatment according to claim 1, it is characterized in that, this medicine is comprised of the component of following mass percent: menthol 0.5%, hyaluronate sodium 0.5%, Aloe extraction solution 8.4%, Tremella extract 4.5%, Sargassum extract 1.5%, deionized water 84.6%.
3. the medicine of a kind of Acne treatment according to claim 1, it is characterized in that, this medicine is comprised of the component of following mass percent: menthol 0.1%, hyaluronate sodium 0.06%, Aloe extraction solution 5.0%, Tremella extract 2.5%, Sargassum extract 1.0%, deionized water 91.34%.
4. the medicine of a kind of Acne treatment according to claim 1, it is characterized in that, this medicine is comprised of the component of following mass percent: menthol 1%, hyaluronate sodium 0.2%, Aloe extraction solution 11%, Tremella extract 8%, Sargassum extract 3%, deionized water 76.8%.
5. the preparation method of the medicine of a kind of Acne treatment described in claim 1～4 any one, is characterized in that, comprises the following steps:
1) take menthol, hyaluronate sodium, Aloe extraction solution, Tremella extract and Sargassum extract;
2) deionized water is added in reactor, be heated to 35～45 ℃, add hyaluronate sodium, continue to be warming up to 50～65 ℃, be incubated 20～40 minutes;
3) add successively respectively menthol, Aloe extraction solution, Tremella extract, Sargassum extract after being cooled to 35～45 ℃;
4) after raw material adds, under the condition of 35～45 ℃, be incubated 10～20 minutes, be then cooled to 20 ℃, obtain product.
6. the preparation method of the medicine of a kind of Acne treatment according to claim 5, is characterized in that, the preparation method of menthol is as follows:
(1) get Herba Menthae herb, with steam distillation, obtain Oleum menthae;
(2) by Oleum menthae in 0～5 ℃ of cold putting, filter, obtain menthol crystal and grease;
(3) by grease frequent pressure fractionating again, collect 202～212 ℃ of fractions, and by it in 0～5 ℃ of cold putting, separate out menthol crystal;
(4) collect all menthol crystal, be dried, obtain menthol finished product.
7. the preparation method of the medicine of a kind of Acne treatment according to claim 5, is characterized in that, the preparation method of hyaluronate sodium is as follows:
(1) cockscomb fragment is joined in acetone, be dipped to hat dehydration hardening, then dry, pulverize to obtain cockscomb powder; Cockscomb powder is poured in container, and added distilled water, stir, more than soaking 24h, make the abundant swelling of cockscomb powder, then filter, collect filtrate, filtering residue soaks 3 times by preceding method again, merges the filtrate of 3 times;
(2) filtrate is poured in container, under agitation add solid oxidation sodium, and add chloroform, stir after 3h, separate water; In the water separating, add ethanol, stir, standing over night, is settled out hyaluronic acid, is then filtered dry precipitate, is drying to obtain crude product;
(3) crude product is dissolved in sodium chloride solution, regulates pH to 4.5～5, then add chloroform with dilute hydrochloric acid, after stratification, sucking-off upper strata water, regulates water pH to 7.5 with sodium hydroxide solution, adds pronase, under the condition of 37 ℃, is incubated 24 hours;
(4) with chloroform extraction, process twice, merge upper strata water, lower floor's liquids recovery chloroform, then in water, add cetylpyridinium chloride solution, and stir, staticly settle, filter collecting precipitation;
(5) use sodium chloride dissolution precipitation, filter, then add ethanol in filtrate, staticly settle, suck upper strata ethanol, ethanol repeated precipitation twice for lower floor, then lower sediment thing is filtered, dry, finally use washing with acetone twice, vacuum drying, obtains hyaluronate sodium finished product.
8. the preparation method of the medicine of a kind of Acne treatment according to claim 5, is characterized in that, the preparation method of Aloe extraction solution is as follows:
(1) with clear water, soak after Folium Aloe, then cleaning blade;
(2) the prune part at blade two ends, is placed on blade in germicidal solution and soaks 10～20 minutes, then drain after cleaning with clear water;
(3) crust of separated aloe leaf and gel, and gel and crust are ground respectively;
(4) deposit after the gel after grinding is degraded by TRANSIENT HIGH TEMPERATURE and make it natural cooling;
(5) juice viscosity after high temperature degradation greatly being reduced carries out coarse filtration, fine straining, removes fiber and precipitate, obtains the juice of clarification, is Aloe extraction solution finished product.
9. the preparation method of the medicine of a kind of Acne treatment according to claim 5, is characterized in that, the preparation method of Tremella extract is as follows:
(1) Tremella is soaked 12～16 hours with water-stop in container, then repeatedly clean repeatedly;
(2) Tremella after cleaning was decocted after 5～7 hours, obtain Tremella extract crude product;
(3) Tremella extract crude product is removed to upper strata offscum, then carry out secondary concentration;
(4) Tremella extract after concentrated is carried out to precipitate with ethanol, precipitate with ethanol, after 12～16 hours, filters, dry, obtains Tremella extract finished product.
10. the preparation method of the medicine of a kind of Acne treatment according to claim 5, is characterized in that, the preparation method of Sargassum extract is as follows:
(1) Sargassum is shredded, add distilled water, in 60 ℃ of water-baths, extract 8 hours, lixiviate 3 times, obtains extracting solution;
(2) extracting solution is concentrated, then add dehydrated alcohol, at 0～10 ℃ standing 12 hours;
(3) centrifugalize, collecting precipitation, lyophilization, obtains Sargassum extract.
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105019105A (en) * | 2015-06-29 | 2015-11-04 | 张家港市杨舍新米洋针织厂 | Production process of anti-bacterial fiber fabric using cool mint |
| CN105287355A (en) * | 2015-11-24 | 2016-02-03 | 广州市花安堂生物科技有限公司 | Acne removing and skin beautifying essence liquid and preparation method thereof |
| CN106492199A (en) * | 2016-12-07 | 2017-03-15 | 珍尔姿（广州）化妆品有限公司 | A kind of nail hydrogel plaster |
| CN106728714A (en) * | 2016-12-07 | 2017-05-31 | 珍尔姿（广州）化妆品有限公司 | A kind of breast-nursing health-care patch |
| CN109303876A (en) * | 2018-12-17 | 2019-02-05 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof for treating acne |
| CN109893484A (en) * | 2019-01-21 | 2019-06-18 | 秋臣化妆品有限公司 | A kind of nourishing moisturizing anti-acne maintenance Essence and preparation method thereof |
| CN110960673A (en) * | 2019-11-20 | 2020-04-07 | 武汉彩芝堂生物医药有限公司 | A kind of Chinese herbal medicine anti-allergy, anti-ringworm and antibacterial ointment and preparation process thereof |
| CN115212123A (en) * | 2022-07-28 | 2022-10-21 | 广州流行美时尚商业股份有限公司 | Plant extract composition for inhibiting sebum secretion and preparation method and application thereof |
| CN116725928A (en) * | 2023-08-14 | 2023-09-12 | 广东尚品汇生物科技有限公司 | Anti-allergy acne-removing traditional Chinese medicine composition, and preparation method and application thereof |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1370588A (en) * | 2002-03-05 | 2002-09-25 | 王舒妍 | Aloe gelatin |
| CN103054762A (en) * | 2011-10-21 | 2013-04-24 | 南通市通州区五接豆豆编织袋厂 | Sophora flower cleanser |
| CN103371942A (en) * | 2012-04-16 | 2013-10-30 | 张斌 | Traditional Chinese medicine acne-removing mask |
| CN103371939A (en) * | 2012-04-16 | 2013-10-30 | 张斌 | Acne removing mask |
-
2014
- 2014-09-11 CN CN201410460072.4A patent/CN104173635A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1370588A (en) * | 2002-03-05 | 2002-09-25 | 王舒妍 | Aloe gelatin |
| CN103054762A (en) * | 2011-10-21 | 2013-04-24 | 南通市通州区五接豆豆编织袋厂 | Sophora flower cleanser |
| CN103371942A (en) * | 2012-04-16 | 2013-10-30 | 张斌 | Traditional Chinese medicine acne-removing mask |
| CN103371939A (en) * | 2012-04-16 | 2013-10-30 | 张斌 | Acne removing mask |
Non-Patent Citations (7)
| Title |
|---|
| 匡海学: "《中药化学》", 31 January 2003, 中国中医药出版社 * |
| 南京中医药大学: "《中药大辞典》", 31 March 2006, 上海科技技术出版社 * |
| 张西园 等: "《你不可不知的100种皮肤保养秘诀》", 31 January 2010, 江苏科学技术出版社 * |
| 徐宝财: "《日用化学品——性能、制备、配方》", 31 January 2008, 化工工业出版社 * |
| 陈晶晶: "《我最想要的300款美肤面膜》", 30 June 2012, 中国纺织出版社 * |
| 齐琳: "《护肤 秀发 美甲 彩妆 装扮一本全》", 31 January 2014, 北京联合出版公司 * |
| 齐香君: "《现代生物制药工艺学》", 28 February 2010, 化工工业出版社 * |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105019105A (en) * | 2015-06-29 | 2015-11-04 | 张家港市杨舍新米洋针织厂 | Production process of anti-bacterial fiber fabric using cool mint |
| CN105287355A (en) * | 2015-11-24 | 2016-02-03 | 广州市花安堂生物科技有限公司 | Acne removing and skin beautifying essence liquid and preparation method thereof |
| CN106492199A (en) * | 2016-12-07 | 2017-03-15 | 珍尔姿（广州）化妆品有限公司 | A kind of nail hydrogel plaster |
| CN106728714A (en) * | 2016-12-07 | 2017-05-31 | 珍尔姿（广州）化妆品有限公司 | A kind of breast-nursing health-care patch |
| CN109303876A (en) * | 2018-12-17 | 2019-02-05 | 曲沃李时珍医药科技有限公司 | A kind of medical facial cold compress gel and preparation method thereof for treating acne |
| CN109893484A (en) * | 2019-01-21 | 2019-06-18 | 秋臣化妆品有限公司 | A kind of nourishing moisturizing anti-acne maintenance Essence and preparation method thereof |
| CN110960673A (en) * | 2019-11-20 | 2020-04-07 | 武汉彩芝堂生物医药有限公司 | A kind of Chinese herbal medicine anti-allergy, anti-ringworm and antibacterial ointment and preparation process thereof |
| CN115212123A (en) * | 2022-07-28 | 2022-10-21 | 广州流行美时尚商业股份有限公司 | Plant extract composition for inhibiting sebum secretion and preparation method and application thereof |
| CN115212123B (en) * | 2022-07-28 | 2023-08-01 | 广州流行美时尚商业股份有限公司 | Plant extract composition for inhibiting sebum secretion and preparation method and application thereof |
| CN116725928A (en) * | 2023-08-14 | 2023-09-12 | 广东尚品汇生物科技有限公司 | Anti-allergy acne-removing traditional Chinese medicine composition, and preparation method and application thereof |
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Application publication date: 20141203 |