CN104027341B - A kind of skin care compositions and methods and preparation thereof - Google Patents
A kind of skin care compositions and methods and preparation thereof Download PDFInfo
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- CN104027341B CN104027341B CN201410280715.7A CN201410280715A CN104027341B CN 104027341 B CN104027341 B CN 104027341B CN 201410280715 A CN201410280715 A CN 201410280715A CN 104027341 B CN104027341 B CN 104027341B
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- 239000000203 mixture Substances 0.000 title claims abstract description 47
- 238000000034 method Methods 0.000 title claims abstract description 31
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 27
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 11
- 150000003625 trehaloses Chemical class 0.000 claims abstract description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 17
- 239000007921 spray Substances 0.000 claims description 16
- 239000003795 chemical substances by application Substances 0.000 claims description 9
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims description 7
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims description 7
- 239000002552 dosage form Substances 0.000 claims description 2
- 206010052428 Wound Diseases 0.000 abstract description 16
- 208000027418 Wounds and injury Diseases 0.000 abstract description 16
- 230000029663 wound healing Effects 0.000 abstract description 11
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 206010063560 Excessive granulation tissue Diseases 0.000 abstract description 4
- 230000002421 anti-septic effect Effects 0.000 abstract description 4
- 210000001126 granulation tissue Anatomy 0.000 abstract description 4
- 235000013406 prebiotics Nutrition 0.000 abstract description 4
- 239000006041 probiotic Substances 0.000 abstract description 4
- 235000018291 probiotics Nutrition 0.000 abstract description 4
- 230000033228 biological regulation Effects 0.000 abstract description 2
- 230000014759 maintenance of location Effects 0.000 abstract description 2
- 206010015150 Erythema Diseases 0.000 description 4
- 230000000740 bleeding effect Effects 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 208000015181 infectious disease Diseases 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010059866 Drug resistance Diseases 0.000 description 3
- 241000588724 Escherichia coli Species 0.000 description 3
- 208000002193 Pain Diseases 0.000 description 3
- 208000003251 Pruritus Diseases 0.000 description 3
- 241000589517 Pseudomonas aeruginosa Species 0.000 description 3
- 241000191967 Staphylococcus aureus Species 0.000 description 3
- 241000194017 Streptococcus Species 0.000 description 3
- 201000010099 disease Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 230000035876 healing Effects 0.000 description 3
- 230000000472 traumatic effect Effects 0.000 description 3
- 206010016326 Feeling cold Diseases 0.000 description 2
- 241000233866 Fungi Species 0.000 description 2
- 241000191963 Staphylococcus epidermidis Species 0.000 description 2
- 208000025865 Ulcer Diseases 0.000 description 2
- 206010048038 Wound infection Diseases 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 238000013019 agitation Methods 0.000 description 2
- 244000052616 bacterial pathogen Species 0.000 description 2
- 230000003796 beauty Effects 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 150000001875 compounds Chemical class 0.000 description 2
- 238000002316 cosmetic surgery Methods 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000012467 final product Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 230000005764 inhibitory process Effects 0.000 description 2
- 230000003020 moisturizing effect Effects 0.000 description 2
- 230000000474 nursing effect Effects 0.000 description 2
- 239000013641 positive control Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 230000008961 swelling Effects 0.000 description 2
- 231100000397 ulcer Toxicity 0.000 description 2
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 206010006784 Burning sensation Diseases 0.000 description 1
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 206010011985 Decubitus ulcer Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 206010017533 Fungal infection Diseases 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 208000031888 Mycoses Diseases 0.000 description 1
- 208000004210 Pressure Ulcer Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 description 1
- 206010053615 Thermal burn Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- -1 ammonium salt compound Chemical class 0.000 description 1
- 239000004599 antimicrobial Substances 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000023555 blood coagulation Effects 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 238000001804 debridement Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000003628 erosive effect Effects 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 230000002045 lasting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000003141 lower extremity Anatomy 0.000 description 1
- 206010025482 malaise Diseases 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 238000012009 microbiological test Methods 0.000 description 1
- 239000004745 nonwoven fabric Substances 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 150000007660 quinolones Chemical class 0.000 description 1
- 239000013558 reference substance Substances 0.000 description 1
- 239000003507 refrigerant Substances 0.000 description 1
- 230000000452 restraining effect Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 229910052709 silver Inorganic materials 0.000 description 1
- 239000004332 silver Substances 0.000 description 1
- 239000004575 stone Substances 0.000 description 1
- 210000001519 tissue Anatomy 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
- 230000037314 wound repair Effects 0.000 description 1
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Abstract
The invention discloses a kind of skin care compositions and methods and preparation thereof, skin care compositions and methods by weight percentage by 4% 20% organosilicon quaternary ammonium salts, 4% 20% trehaloses, 60% 92% glycerol compositions.The skin care compositions and methods broad-spectrum antiseptic of the present invention, moisture retention is high, it is provided that the growing environment of granulation tissue, protects wound surface；Promote the growth of the antibacterial of regulation human body microecological balance, it is possible to prebiotic probiotics, accelerate wound healing, with low cost.
Description
Technical field
The present invention relates to a kind of biomedicine technical field, be specifically related to skin care compositions and methods and preparation thereof.
Background technology
Wound surface disease has become one of the highest disease of society sickness rate, either postoperative wound surface or traumatic surface also or
Being the wound surface caused by reason such as ulcer, erosion, burn and scald, the problems such as easy infection, healing are slow have the most become puzzlement doctor and have liked to be beautiful
The difficult problem of personage.
The agglutination of wound surface is broadly divided into blood coagulation phase, inflammatory phase, reparation phase.In general, the agglutination of wound surface to reach
More than two weeks, during this period, traumatic infection and wound surface humidity were the modal reasons affecting wound healing, without very well
Control make wound infection, the most easily cause the quiet chronic ulcer of pressure ulcer, lower limb, make the course of disease extend, patient is more painful.
Except there being general staphylococcus aureus, escherichia coli, outside the infection that streptococcus is outer caused, there is also bacillus pyocyaneus,
Tubercule bacillus and the possibility of fungal infection.At present, the main method controlling wound infection is local debridement and medication, but in wound
Face position uses antimicrobial drug (quinolones) or antibiotic, easily produces drug resistance.
Everybody has a love of beauty, and along with the raising of people's economic level, people are also willing to be intended to pursue on beautiful road spend more
Money, has then had a series of beauty treatment means, and such as, laser photorejuvenation, fruit acid change skin etc., but these expensive technology
Means, it is also possible to bring side effect, may make red swelling of the skin burning pain.
Quarternary ammonium salt compound can adsorb electronegative antibacterial, has good bactericidal action, uses in the world extensively.Grind
Studying carefully and show, organosilicon quaternary ammonium salt is non-stimulated and carcinogenesis to human body skin, but also has good resistance tocrocking, and not
The problem that there is Drug resistance bacterium.Organosilicon quaternary ammonium salt is a class Novel Cationic Surfactants, and it has high temperature resistant, lasting
Effect, scope of restraining fungi is wide, can effectively suppress gram positive bacteria, gram negative bacteria, yeast and fungus.
At present, need one badly and get final product broad-spectrum antiseptic, but be difficult to make pathogenic bacteria produce drug resistance, it is possible to prebiotic probiotics, protect simultaneously
Wet, it is provided that the growing environment of granulation tissue, accelerate healing speed, alleviate the skin nursing combination of damaged skin red and swollen heat pain
Thing.
Summary of the invention
It is an object of the invention to overcome the deficiencies in the prior art, it is provided that one gets final product broad-spectrum antiseptic, but it is resistance to be difficult to make pathogenic bacteria produce
The property of medicine, it is possible to prebiotic probiotics, simultaneously moisturizing, it is provided that the growing environment of granulation tissue, accelerates healing speed, and alleviation is subject to
Damage the skin care compositions and methods of red swelling of the skin burning pain.
Second object of the present invention is to provide a kind of preparation containing skin care compositions and methods.
Technical scheme is summarized as follows:
Skin care compositions and methods, by weight percentage by 4% 20% organosilicon quaternary ammonium salts, 4% 20% trehaloses, 60% 92% glycerol
Composition.
Preferably organosilicon quaternary ammonium salt is 14%, and trehalose is 14%, and described glycerol is 72%.
Comprise the preparation of skin care compositions and methods, by weight percentage by 5% 28% skin care compositions and methods and 72 95% water groups
Become.
Preferably skin care compositions and methods is 14%, and water is 86%.
The dosage form of above-mentioned preparation is face film agent or spray.
The skin care compositions and methods broad-spectrum antiseptic of the present invention, moisture retention is high, it is provided that the growing environment of granulation tissue, protects wound surface；
Promote the growth of the antibacterial of regulation human body microecological balance, it is possible to prebiotic probiotics, accelerate wound healing, with low cost.
Detailed description of the invention
Trehalose has effect of moisturizing, can make that skin jade-like stone is bright, gloss, tender, and the normal humidity keeping wound surface can also be meat
The growth of bud tissue and wound surface epithelization provide good condition, thus accelerate wound healing.
Below in conjunction with specific embodiment, the present invention is further illustrated.
Embodiment 1
Skin care compositions and methods, by weight percentage by 14% organosilicon quaternary ammonium salt, 14% trehalose, 72% glycerol composition.
Embodiment 2
Skin care compositions and methods, by weight percentage by 4% organosilicon quaternary ammonium salt, 8% trehalose, 88% glycerol composition.
Embodiment 3
Skin care compositions and methods, by weight percentage by 4% organosilicon quaternary ammonium salt, 4% trehalose, 92% glycerol composition.
Embodiment 4
Skin care compositions and methods, by weight percentage by 20% organosilicon quaternary ammonium salt, 20% trehalose, 60% glycerol composition.
Embodiment 5
Comprise the preparation of skin care compositions and methods, it is characterised in that the skin prepared by the embodiment 1 of 14% by weight percentage protects
Reason compositions and 86% water composition, make spray.
Above-mentioned formula can also make face film agent.
Embodiment 6
Comprise the preparation of skin care compositions and methods, it is characterised in that the skin nursing prepared by weight percentage by the embodiment 2 of 5%
Compositions and 95% water composition, make spray.
Above-mentioned formula can also make face film agent.
Embodiment 7
Comprise the preparation of skin care compositions and methods, it is characterised in that the skin prepared by the embodiment 3 of 28% by weight percentage protects
Reason compositions and 72% water composition, make spray.
Above-mentioned formula can also make face film agent.
Embodiment 8
Comprise the preparation of skin care compositions and methods, it is characterised in that the skin prepared by the embodiment 4 of 10% by weight percentage protects
Reason compositions and 90% water composition, make spray.
Above-mentioned formula can also make face film agent.
Embodiment 9
The compound method of spray:
Take skin care compositions and methods by one of embodiment 58 formula to be placed in beaker, mix homogeneously, then take phase by weight percentage
The water answered adds, and mixes to obtain mixed liquor, under agitation, heating in water bath to 90 DEG C, keeps this temperature to stir 30min, takes out,
It is cooled to room temperature, puts in medicinal high density polyethylene (HDPE) spray bottle.
Embodiment 10
The compound method of face film agent:
(1) skin care compositions and methods weighing one of embodiment 58 is placed in beaker, mix homogeneously, then water intaking adds by weight percentage
Enter, mix to obtain mixed liquor, under agitation, heating in water bath to 90 DEG C, keep this temperature to stir 30min, take out, be cooled to room
Temperature；
(2) non-woven fabrics is immersed in the liquid that step (1) obtains, after complete wetting, take out, put in packaging bag, sealing.
Embodiment 11
The spray antibacterial tests of the present invention
According to the spray of " medicine Micro biological Tests handbook " the 18th chapter Section 1 cup-plate method present invention to staphylococcus aureus,
Escherichia coli, streptococcus, Pseudomonas aeruginosa, the bacteriostasis of staphylococcus epidermidis, staphylococcus aureus, escherichia coli,
Streptococcus, bacillus pyocyaneus and staphylococcus epidermidis are the main bacteria of traumatic infection.The size of inhibition zone represents spray antimicrbial power
Just.The positive reference substance i.e. anti-bacteriostasis spray of Joel Silver wound surface (Xiang Nuo bio tech ltd, Shanghai).
Table 1, the size (unit: mm) of inhibition zone
It is computed: < 0.05, there were significant differences for embodiment 5P=0.039；
Embodiment 6P=0.008 < 0.01, there is pole significant difference；
< 0.05, there were significant differences for embodiment 7P=0.049；
Embodiment 8P=0.0028 < 0.01, there is pole significant difference.
Embodiment 12
Wound healing and hemostasis trial.
Taking 30 sd male rats, be randomly divided into 6 groups, often group 5, in back spinal side, cuts off hair, uses scalpel
Cut long 2cm, the edge of a knife of degree of depth 0.2cm, then at knife-edge part label respectively, embodiment group wound uses embodiment 5-8 respectively
Preparation (spray), positive controls use wound repair spray (Suzhou Ruimei Biotechnology Co., Ltd.), blank
Group, does not use any medicine, observes the mice bleeding time.Blotting outflow blood every 0.5 minute with clean filter paper, filter paper is not
Skin to be contacted, until the bleeding time stops naturally, the stopwatch record time, is shown in Table 2.
Morning, noon and afternoon every day spray the preparation (spray) being made up of embodiment three times, observe wound healing situation.
Wound healing situation is evaluated with Wound healing rate.Not Wound healing rate=(original wound surface area-do not heal wound surface area)/original
Wound surface area.With image J software processes picture, calculate Wound healing rate, be shown in Table 3.
Table 2, bleeding time (often group calculates average) (unit: min)
| Embodiment 5 | Embodiment 6 | Embodiment 7 | Embodiment 8 | Positive control | Blank | |
| Bleeding time | 2.59 | 2.46 | 2.38 | 3.05 | 4.49 | 7.25 |
Table 3, wound healing situation (often group calculates average) (unit: %)
Embodiment 13
Lee, the face skin that laser is caused after changing skin cosmetic surgery failure is rubescent, obscure tarnish, and scorching hot pruritus uses real
Executing example 6 face film agent, spread on affected part after cleaning illing skin, every day is the most each with once.
After using 2 hours, make use feeling cool；Comfortable；Burning sensation disappears；No longer pruritus；
In morning next day, skin still water moistens；
3rd day, skin redness started to shoal；Routine work can be recovered, the most also will not feel to itch；
5th day, skin redness substantially shoaled, and a whole day all water profit is glossy；
7th day, face recovered face impaired before state；
Tenth day, than the profit that the most more adds water, glossy, skin also became tender.
Embodiment 14
Tang, the face skin that laser is caused after changing skin cosmetic surgery failure is rubescent, swells and ache, and skin is tight to be dried, and uses reality
Executing example 7 face film agent, take gel and be applied to affected part after cleaning illing skin, every day is the most each with once.
After using 1 hour, make use feeling cool；Water moistens；
In morning next day, skin is the most refrigerant, water profit；
3rd day, skin redness started to shoal；Face is painless；
5th day, face started detumescence；
7th day, face recovered the state before operation.
Claims (5)
1. a skin care compositions and methods, is characterized in that by weight percentage by 4% 20% organosilicon quaternary ammonium salts, 4% 20% trehaloses,
60% 92% glycerol compositions.
Skin care compositions and methods the most according to claim 1, is characterized in that described organosilicon quaternary ammonium salt is 14%, and trehalose is
14%, described glycerol is 72%.
The preparation of skin care compositions and methods the most according to claim 1, it is characterised in that by weight percentage by 5% 28% skin
Skin care composition and 72 95% water composition.
Preparation the most according to claim 3, is characterized in that described skin care compositions and methods is 14%, and described water is 86%.
Preparation the most according to claim 4, is characterized in that the dosage form of described preparation is face film agent or spray.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410280715.7A CN104027341B (en) | 2014-06-20 | 2014-06-20 | A kind of skin care compositions and methods and preparation thereof |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410280715.7A CN104027341B (en) | 2014-06-20 | 2014-06-20 | A kind of skin care compositions and methods and preparation thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN104027341A CN104027341A (en) | 2014-09-10 |
| CN104027341B true CN104027341B (en) | 2016-08-31 |
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| CN201410280715.7A Active CN104027341B (en) | 2014-06-20 | 2014-06-20 | A kind of skin care compositions and methods and preparation thereof |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN105769844B (en) * | 2016-05-25 | 2019-01-11 | 天津嘉氏堂医美科技有限公司 | Arginine-containing composition and preparation |
| CN107334653A (en) * | 2017-07-12 | 2017-11-10 | 南雄鼎成新材料科技有限公司 | A kind of antibacterial anti-dandruff and itching-relieving shampoo with treatment containing organosilicon quaternary ammonium salt |
| CN108524315A (en) * | 2018-06-29 | 2018-09-14 | 广州市润研基因科技有限公司 | A kind of novel anti-pollution moisturizing skin makeup liquid and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| MY142987A (en) * | 2005-06-08 | 2011-02-14 | Hayashibara Biochem Lab | Solution for tissue adhesion prevention and method for tissue adhesion prevention |
| CN100471499C (en) * | 2006-08-11 | 2009-03-25 | 陈炎武 | Physical bacteria resisting net liquid of human body and the producing technique |
| KR100937816B1 (en) * | 2007-06-21 | 2010-01-20 | 주식회사 원바이오젠 | Manufacturing method of hydrophilic foam dressing material and manufactured hydrophilic foam dressing material |
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