CN103957704A - Microbicidal composition - Google Patents
Microbicidal composition Download PDFInfo
- Publication number
- CN103957704A CN103957704A CN201280060222.1A CN201280060222A CN103957704A CN 103957704 A CN103957704 A CN 103957704A CN 201280060222 A CN201280060222 A CN 201280060222A CN 103957704 A CN103957704 A CN 103957704A
- Authority
- CN
- China
- Prior art keywords
- dimethyl
- alcohol
- octa
- phenol
- weight ratio
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 181
- 230000003641 microbiacidal effect Effects 0.000 title claims abstract description 60
- 230000002195 synergetic effect Effects 0.000 claims abstract description 53
- 229940124561 microbicide Drugs 0.000 claims abstract description 42
- 239000002855 microbicide agent Substances 0.000 claims abstract description 39
- -1 monosubstitutedphenols Chemical class 0.000 claims abstract description 28
- MPWGZBWDLMDIHO-UHFFFAOYSA-N 3-propylphenol Chemical compound CCCC1=CC=CC(O)=C1 MPWGZBWDLMDIHO-UHFFFAOYSA-N 0.000 claims description 56
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 49
- 239000004094 surface-active agent Substances 0.000 claims description 46
- GLZPCOQZEFWAFX-UHFFFAOYSA-N Geraniol Chemical compound CC(C)=CCCC(C)=CCO GLZPCOQZEFWAFX-UHFFFAOYSA-N 0.000 claims description 42
- LCHYEKKJCUJAKN-UHFFFAOYSA-N 2-propylphenol Chemical compound CCCC1=CC=CC=C1O LCHYEKKJCUJAKN-UHFFFAOYSA-N 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 31
- IJALWSVNUBBQRA-UHFFFAOYSA-N 4-Isopropyl-3-methylphenol Chemical compound CC(C)C1=CC=C(O)C=C1C IJALWSVNUBBQRA-UHFFFAOYSA-N 0.000 claims description 29
- CDOSHBSSFJOMGT-UHFFFAOYSA-N linalool Chemical class CC(C)=CCCC(C)(O)C=C CDOSHBSSFJOMGT-UHFFFAOYSA-N 0.000 claims description 29
- RECUKUPTGUEGMW-UHFFFAOYSA-N carvacrol Chemical compound CC(C)C1=CC=C(C)C(O)=C1 RECUKUPTGUEGMW-UHFFFAOYSA-N 0.000 claims description 27
- HHTWOMMSBMNRKP-UHFFFAOYSA-N carvacrol Natural products CC(=C)C1=CC=C(C)C(O)=C1 HHTWOMMSBMNRKP-UHFFFAOYSA-N 0.000 claims description 27
- KLSLBUSXWBJMEC-UHFFFAOYSA-N 4-Propylphenol Chemical compound CCCC1=CC=C(O)C=C1 KLSLBUSXWBJMEC-UHFFFAOYSA-N 0.000 claims description 25
- ZDUIHRJGDMTBEX-UHFFFAOYSA-N 3-methyl-5-propan-2-ylphenol Chemical compound CC(C)C1=CC(C)=CC(O)=C1 ZDUIHRJGDMTBEX-UHFFFAOYSA-N 0.000 claims description 24
- CYYZDBDROVLTJU-UHFFFAOYSA-N 4-n-Butylphenol Chemical compound CCCCC1=CC=C(O)C=C1 CYYZDBDROVLTJU-UHFFFAOYSA-N 0.000 claims description 24
- CYEKUDPFXBLGHH-UHFFFAOYSA-N 3-tert-Butylphenol Chemical compound CC(C)(C)C1=CC=CC(O)=C1 CYEKUDPFXBLGHH-UHFFFAOYSA-N 0.000 claims description 23
- NGFPWHGISWUQOI-UHFFFAOYSA-N 2-sec-butylphenol Chemical compound CCC(C)C1=CC=CC=C1O NGFPWHGISWUQOI-UHFFFAOYSA-N 0.000 claims description 22
- 239000000344 soap Substances 0.000 claims description 22
- ZUTYZAFDFLLILI-UHFFFAOYSA-N 4-sec-Butylphenol Chemical compound CCC(C)C1=CC=C(O)C=C1 ZUTYZAFDFLLILI-UHFFFAOYSA-N 0.000 claims description 16
- GLZPCOQZEFWAFX-YFHOEESVSA-N Geraniol Natural products CC(C)=CCC\C(C)=C/CO GLZPCOQZEFWAFX-YFHOEESVSA-N 0.000 claims description 14
- 239000005792 Geraniol Substances 0.000 claims description 14
- 229940113087 geraniol Drugs 0.000 claims description 14
- GLZPCOQZEFWAFX-JXMROGBWSA-N Nerol Natural products CC(C)=CCC\C(C)=C\CO GLZPCOQZEFWAFX-JXMROGBWSA-N 0.000 claims description 7
- 230000001954 sterilising effect Effects 0.000 claims description 7
- 238000004659 sterilization and disinfection Methods 0.000 claims description 7
- 239000001490 (3R)-3,7-dimethylocta-1,6-dien-3-ol Substances 0.000 claims description 6
- CDOSHBSSFJOMGT-JTQLQIEISA-N (R)-linalool Natural products CC(C)=CCC[C@@](C)(O)C=C CDOSHBSSFJOMGT-JTQLQIEISA-N 0.000 claims description 6
- 229930007744 linalool Natural products 0.000 claims description 6
- 150000008051 alkyl sulfates Chemical class 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 abstract description 75
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract description 17
- 235000007586 terpenes Nutrition 0.000 abstract description 3
- NKXINWNCBKRRIC-UHFFFAOYSA-N 2-methyl-3-propan-2-ylphenol Chemical class CC(C)C1=CC=CC(O)=C1C NKXINWNCBKRRIC-UHFFFAOYSA-N 0.000 abstract 1
- 238000012360 testing method Methods 0.000 description 104
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 30
- 244000005700 microbiome Species 0.000 description 29
- 238000004140 cleaning Methods 0.000 description 23
- 239000000243 solution Substances 0.000 description 21
- 230000001580 bacterial effect Effects 0.000 description 20
- 239000003795 chemical substances by application Substances 0.000 description 20
- 239000002904 solvent Substances 0.000 description 19
- 241000894006 Bacteria Species 0.000 description 17
- 230000012010 growth Effects 0.000 description 17
- 239000003921 oil Substances 0.000 description 17
- 235000019198 oils Nutrition 0.000 description 17
- 238000010790 dilution Methods 0.000 description 15
- 239000012895 dilution Substances 0.000 description 15
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 14
- 239000007788 liquid Substances 0.000 description 14
- 230000007246 mechanism Effects 0.000 description 14
- 241000191967 Staphylococcus aureus Species 0.000 description 13
- 239000000463 material Substances 0.000 description 13
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 12
- 230000003213 activating effect Effects 0.000 description 12
- XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 12
- 239000000839 emulsion Substances 0.000 description 12
- 230000002147 killing effect Effects 0.000 description 12
- HPXRVTGHNJAIIH-UHFFFAOYSA-N cyclohexanol Chemical compound OC1CCCCC1 HPXRVTGHNJAIIH-UHFFFAOYSA-N 0.000 description 11
- 235000014113 dietary fatty acids Nutrition 0.000 description 11
- 230000000694 effects Effects 0.000 description 11
- 229930195729 fatty acid Natural products 0.000 description 11
- 239000000194 fatty acid Substances 0.000 description 11
- 239000012530 fluid Substances 0.000 description 11
- 238000002360 preparation method Methods 0.000 description 11
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Chemical compound CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 description 10
- 239000007787 solid Substances 0.000 description 10
- 241000588724 Escherichia coli Species 0.000 description 9
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 9
- 150000004665 fatty acids Chemical class 0.000 description 9
- 238000005406 washing Methods 0.000 description 9
- KFZXVMNBUMVKLN-UHFFFAOYSA-N 4-chloro-5-methyl-2-propan-2-ylphenol Chemical compound CC(C)C1=CC(Cl)=C(C)C=C1O KFZXVMNBUMVKLN-UHFFFAOYSA-N 0.000 description 8
- 230000000249 desinfective effect Effects 0.000 description 8
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 7
- 239000004530 micro-emulsion Substances 0.000 description 7
- 210000000214 mouth Anatomy 0.000 description 7
- 150000002989 phenols Chemical class 0.000 description 7
- JWAZRIHNYRIHIV-UHFFFAOYSA-N 2-naphthol Chemical compound C1=CC=CC2=CC(O)=CC=C21 JWAZRIHNYRIHIV-UHFFFAOYSA-N 0.000 description 6
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
- 230000000844 anti-bacterial effect Effects 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 6
- 239000012141 concentrate Substances 0.000 description 6
- 239000004567 concrete Substances 0.000 description 6
- 235000019197 fats Nutrition 0.000 description 6
- 239000002609 medium Substances 0.000 description 6
- 230000000474 nursing effect Effects 0.000 description 6
- 230000008569 process Effects 0.000 description 6
- 235000019260 propionic acid Nutrition 0.000 description 6
- IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 6
- 239000011780 sodium chloride Substances 0.000 description 6
- 239000000758 substrate Substances 0.000 description 6
- 239000000725 suspension Substances 0.000 description 6
- 235000019737 Animal fat Nutrition 0.000 description 5
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
- 235000010469 Glycine max Nutrition 0.000 description 5
- 244000068988 Glycine max Species 0.000 description 5
- 230000009471 action Effects 0.000 description 5
- 239000003570 air Substances 0.000 description 5
- WUOACPNHFRMFPN-UHFFFAOYSA-N alpha-terpineol Chemical compound CC1=CCC(C(C)(C)O)CC1 WUOACPNHFRMFPN-UHFFFAOYSA-N 0.000 description 5
- 125000000129 anionic group Chemical group 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 239000000645 desinfectant Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 230000036541 health Effects 0.000 description 5
- 244000144972 livestock Species 0.000 description 5
- 239000012266 salt solution Substances 0.000 description 5
- 238000010998 test method Methods 0.000 description 5
- CDMGNVWZXRKJNS-UHFFFAOYSA-N 2-benzylphenol Chemical compound OC1=CC=CC=C1CC1=CC=CC=C1 CDMGNVWZXRKJNS-UHFFFAOYSA-N 0.000 description 4
- ZNPSUQQXTRRSBM-UHFFFAOYSA-N 4-n-Pentylphenol Chemical compound CCCCCC1=CC=C(O)C=C1 ZNPSUQQXTRRSBM-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 229920002472 Starch Polymers 0.000 description 4
- BKDZVPVJIXZYBH-UHFFFAOYSA-N [Na].C(C)(=O)O.NC(=N)N Chemical compound [Na].C(C)(=O)O.NC(=N)N BKDZVPVJIXZYBH-UHFFFAOYSA-N 0.000 description 4
- 238000002835 absorbance Methods 0.000 description 4
- 239000002280 amphoteric surfactant Substances 0.000 description 4
- 239000003945 anionic surfactant Substances 0.000 description 4
- 210000004027 cell Anatomy 0.000 description 4
- 239000006185 dispersion Substances 0.000 description 4
- 238000004519 manufacturing process Methods 0.000 description 4
- 238000006386 neutralization reaction Methods 0.000 description 4
- 239000004033 plastic Substances 0.000 description 4
- 229920003023 plastic Polymers 0.000 description 4
- 238000012545 processing Methods 0.000 description 4
- 239000003380 propellant Substances 0.000 description 4
- 239000008107 starch Substances 0.000 description 4
- 235000019698 starch Nutrition 0.000 description 4
- DCXXMTOCNZCJGO-UHFFFAOYSA-N tristearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCCCC)COC(=O)CCCCCCCCCCCCCCCCC DCXXMTOCNZCJGO-UHFFFAOYSA-N 0.000 description 4
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 3
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 239000012190 activator Substances 0.000 description 3
- 239000000654 additive Substances 0.000 description 3
- 230000000996 additive effect Effects 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 229950011260 betanaphthol Drugs 0.000 description 3
- 150000001768 cations Chemical class 0.000 description 3
- OMFXVFTZEKFJBZ-HJTSIMOOSA-N corticosterone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@H](CC4)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OMFXVFTZEKFJBZ-HJTSIMOOSA-N 0.000 description 3
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- 238000011010 flushing procedure Methods 0.000 description 3
- 235000013905 glycine and its sodium salt Nutrition 0.000 description 3
- 239000004247 glycine and its sodium salt Substances 0.000 description 3
- NFIDBGJMFKNGGQ-UHFFFAOYSA-N isopropylmethylphenol Natural products CC(C)CC1=CC=CC=C1O NFIDBGJMFKNGGQ-UHFFFAOYSA-N 0.000 description 3
- 235000015097 nutrients Nutrition 0.000 description 3
- 229910052700 potassium Inorganic materials 0.000 description 3
- 239000011591 potassium Substances 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 229910052708 sodium Inorganic materials 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 229940029258 sodium glycinate Drugs 0.000 description 3
- WUWHFEHKUQVYLF-UHFFFAOYSA-M sodium;2-aminoacetate Chemical compound [Na+].NCC([O-])=O WUWHFEHKUQVYLF-UHFFFAOYSA-M 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 3
- 239000002562 thickening agent Substances 0.000 description 3
- 239000000606 toothpaste Substances 0.000 description 3
- 229940034610 toothpaste Drugs 0.000 description 3
- 229920001817 Agar Polymers 0.000 description 2
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 description 2
- 235000017060 Arachis glabrata Nutrition 0.000 description 2
- 244000105624 Arachis hypogaea Species 0.000 description 2
- 235000010777 Arachis hypogaea Nutrition 0.000 description 2
- 235000018262 Arachis monticola Nutrition 0.000 description 2
- 244000060011 Cocos nucifera Species 0.000 description 2
- 235000013162 Cocos nucifera Nutrition 0.000 description 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 2
- 241000588722 Escherichia Species 0.000 description 2
- 239000004258 Ethoxyquin Substances 0.000 description 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical group C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 2
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 2
- 235000019774 Rice Bran oil Nutrition 0.000 description 2
- 239000000853 adhesive Substances 0.000 description 2
- 230000001070 adhesive effect Effects 0.000 description 2
- 239000008272 agar Substances 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 239000002585 base Substances 0.000 description 2
- 239000002199 base oil Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 239000004443 bio-dispersant Substances 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 150000001734 carboxylic acid salts Chemical class 0.000 description 2
- 235000007746 carvacrol Nutrition 0.000 description 2
- 125000002091 cationic group Chemical group 0.000 description 2
- 239000002738 chelating agent Substances 0.000 description 2
- MRUAUOIMASANKQ-UHFFFAOYSA-N cocamidopropyl betaine Chemical compound CCCCCCCCCCCC(=O)NCCC[N+](C)(C)CC([O-])=O MRUAUOIMASANKQ-UHFFFAOYSA-N 0.000 description 2
- 229940073507 cocamidopropyl betaine Drugs 0.000 description 2
- 230000009133 cooperative interaction Effects 0.000 description 2
- 239000002537 cosmetic Substances 0.000 description 2
- 230000001186 cumulative effect Effects 0.000 description 2
- SQIFACVGCPWBQZ-UHFFFAOYSA-N delta-terpineol Natural products CC(C)(O)C1CCC(=C)CC1 SQIFACVGCPWBQZ-UHFFFAOYSA-N 0.000 description 2
- 238000009795 derivation Methods 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 239000003995 emulsifying agent Substances 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- DECIPOUIJURFOJ-UHFFFAOYSA-N ethoxyquin Chemical compound N1C(C)(C)C=C(C)C2=CC(OCC)=CC=C21 DECIPOUIJURFOJ-UHFFFAOYSA-N 0.000 description 2
- 229940093500 ethoxyquin Drugs 0.000 description 2
- 235000019285 ethoxyquin Nutrition 0.000 description 2
- 238000002474 experimental method Methods 0.000 description 2
- 239000004744 fabric Substances 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 235000013569 fruit product Nutrition 0.000 description 2
- 239000000499 gel Substances 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 230000012447 hatching Effects 0.000 description 2
- 239000001257 hydrogen Substances 0.000 description 2
- 229910052739 hydrogen Inorganic materials 0.000 description 2
- 125000002887 hydroxy group Chemical group [H]O* 0.000 description 2
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 2
- 238000011534 incubation Methods 0.000 description 2
- 239000003112 inhibitor Substances 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- WYXXLXHHWYNKJF-UHFFFAOYSA-N isocarvacrol Natural products CC(C)C1=CC=C(O)C(C)=C1 WYXXLXHHWYNKJF-UHFFFAOYSA-N 0.000 description 2
- 239000010985 leather Substances 0.000 description 2
- 239000006210 lotion Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 238000002156 mixing Methods 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 235000020232 peanut Nutrition 0.000 description 2
- 239000000049 pigment Substances 0.000 description 2
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 2
- 230000004224 protection Effects 0.000 description 2
- 239000008165 rice bran oil Substances 0.000 description 2
- 150000003839 salts Chemical class 0.000 description 2
- 238000013207 serial dilution Methods 0.000 description 2
- 239000002453 shampoo Substances 0.000 description 2
- 239000003381 stabilizer Substances 0.000 description 2
- 238000003860 storage Methods 0.000 description 2
- 239000011885 synergistic combination Substances 0.000 description 2
- 239000003760 tallow Substances 0.000 description 2
- 229940116411 terpineol Drugs 0.000 description 2
- MGSRCZKZVOBKFT-UHFFFAOYSA-N thymol Chemical compound CC(C)C1=CC=C(C)C=C1O MGSRCZKZVOBKFT-UHFFFAOYSA-N 0.000 description 2
- URAYPUMNDPQOKB-UHFFFAOYSA-N triacetin Chemical compound CC(=O)OCC(OC(C)=O)COC(C)=O URAYPUMNDPQOKB-UHFFFAOYSA-N 0.000 description 2
- 238000002255 vaccination Methods 0.000 description 2
- VKZRWSNIWNFCIQ-WDSKDSINSA-N (2s)-2-[2-[[(1s)-1,2-dicarboxyethyl]amino]ethylamino]butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NCCN[C@H](C(O)=O)CC(O)=O VKZRWSNIWNFCIQ-WDSKDSINSA-N 0.000 description 1
- RSWGJHLUYNHPMX-UHFFFAOYSA-N 1,4a-dimethyl-7-propan-2-yl-2,3,4,4b,5,6,10,10a-octahydrophenanthrene-1-carboxylic acid Chemical compound C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 description 1
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 1
- OAAZUWWNSYWWHG-UHFFFAOYSA-N 1-phenoxypropan-1-ol Chemical compound CCC(O)OC1=CC=CC=C1 OAAZUWWNSYWWHG-UHFFFAOYSA-N 0.000 description 1
- PQHYOGIRXOKOEJ-UHFFFAOYSA-N 2-(1,2-dicarboxyethylamino)butanedioic acid Chemical compound OC(=O)CC(C(O)=O)NC(C(O)=O)CC(O)=O PQHYOGIRXOKOEJ-UHFFFAOYSA-N 0.000 description 1
- WRMNZCZEMHIOCP-UHFFFAOYSA-N 2-phenylethanol Chemical compound OCCC1=CC=CC=C1 WRMNZCZEMHIOCP-UHFFFAOYSA-N 0.000 description 1
- HNNQYHFROJDYHQ-UHFFFAOYSA-N 3-(4-ethylcyclohexyl)propanoic acid 3-(3-ethylcyclopentyl)propanoic acid Chemical compound CCC1CCC(CCC(O)=O)C1.CCC1CCC(CCC(O)=O)CC1 HNNQYHFROJDYHQ-UHFFFAOYSA-N 0.000 description 1
- HJSPWKGEPDZNLK-UHFFFAOYSA-N 4-benzylphenol Chemical compound C1=CC(O)=CC=C1CC1=CC=CC=C1 HJSPWKGEPDZNLK-UHFFFAOYSA-N 0.000 description 1
- DHMQDGOQFOQNFH-UHFFFAOYSA-M Aminoacetate Chemical compound NCC([O-])=O DHMQDGOQFOQNFH-UHFFFAOYSA-M 0.000 description 1
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 description 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 description 1
- DKPFZGUDAPQIHT-UHFFFAOYSA-N Butyl acetate Natural products CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 1
- YRDSOLWPGUPXHB-UHFFFAOYSA-N C(C)(=O)C(C(C(C(=O)O)(C(C)=O)C(C)=O)(O)C(=O)O)C(=O)O.C(CC(O)(C(=O)OC(C)=O)CC(=O)OC(C)=O)(=O)OC(C)=O Chemical compound C(C)(=O)C(C(C(C(=O)O)(C(C)=O)C(C)=O)(O)C(=O)O)C(=O)O.C(CC(O)(C(=O)OC(C)=O)CC(=O)OC(C)=O)(=O)OC(C)=O YRDSOLWPGUPXHB-UHFFFAOYSA-N 0.000 description 1
- 229910021532 Calcite Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- UGFAIRIUMAVXCW-UHFFFAOYSA-N Carbon monoxide Chemical compound [O+]#[C-] UGFAIRIUMAVXCW-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 241000195493 Cryptophyta Species 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 241000233866 Fungi Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 239000004471 Glycine Substances 0.000 description 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 229910002651 NO3 Inorganic materials 0.000 description 1
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 description 1
- 240000007594 Oryza sativa Species 0.000 description 1
- 235000007164 Oryza sativa Nutrition 0.000 description 1
- 235000019482 Palm oil Nutrition 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 229920001131 Pulp (paper) Polymers 0.000 description 1
- 235000004443 Ricinus communis Nutrition 0.000 description 1
- 240000000528 Ricinus communis Species 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
- 235000019486 Sunflower oil Nutrition 0.000 description 1
- 239000005844 Thymol Substances 0.000 description 1
- XEFQLINVKFYRCS-UHFFFAOYSA-N Triclosan Chemical compound OC1=CC(Cl)=CC=C1OC1=CC=C(Cl)C=C1Cl XEFQLINVKFYRCS-UHFFFAOYSA-N 0.000 description 1
- 125000002252 acyl group Chemical group 0.000 description 1
- 238000003483 aging Methods 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 239000003619 algicide Substances 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910001413 alkali metal ion Inorganic materials 0.000 description 1
- 150000001340 alkali metals Chemical class 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 229910001420 alkaline earth metal ion Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 125000000217 alkyl group Chemical class 0.000 description 1
- 125000005227 alkyl sulfonate group Chemical group 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 230000008485 antagonism Effects 0.000 description 1
- 239000010692 aromatic oil Substances 0.000 description 1
- 239000012298 atmosphere Substances 0.000 description 1
- 239000010480 babassu oil Substances 0.000 description 1
- 239000003899 bactericide agent Substances 0.000 description 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 description 1
- 235000013361 beverage Nutrition 0.000 description 1
- 239000003139 biocide Substances 0.000 description 1
- 238000004364 calculation method Methods 0.000 description 1
- 229940041514 candida albicans extract Drugs 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 229910002091 carbon monoxide Inorganic materials 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 239000012876 carrier material Substances 0.000 description 1
- 239000004359 castor oil Substances 0.000 description 1
- 235000019438 castor oil Nutrition 0.000 description 1
- 229960001777 castor oil Drugs 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 239000000919 ceramic Substances 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003610 charcoal Substances 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 239000011093 chipboard Substances 0.000 description 1
- 239000000460 chlorine Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000004927 clay Substances 0.000 description 1
- 229910052570 clay Inorganic materials 0.000 description 1
- 239000012459 cleaning agent Substances 0.000 description 1
- 230000003749 cleanliness Effects 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 235000019868 cocoa butter Nutrition 0.000 description 1
- 229940110456 cocoa butter Drugs 0.000 description 1
- 229940065856 cocoyl glycinate Drugs 0.000 description 1
- 238000004040 coloring Methods 0.000 description 1
- 239000002131 composite material Substances 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 230000001143 conditioned effect Effects 0.000 description 1
- 230000003750 conditioning effect Effects 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 239000006184 cosolvent Substances 0.000 description 1
- 235000012343 cottonseed oil Nutrition 0.000 description 1
- 125000004122 cyclic group Chemical group 0.000 description 1
- 125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 description 1
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 description 1
- 125000002433 cyclopentenyl group Chemical group C1(=CCCC1)* 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000000151 deposition Methods 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 239000008121 dextrose Substances 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- IEJIGPNLZYLLBP-UHFFFAOYSA-N dimethyl carbonate Chemical compound COC(=O)OC IEJIGPNLZYLLBP-UHFFFAOYSA-N 0.000 description 1
- 229960001760 dimethyl sulfoxide Drugs 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 239000010459 dolomite Substances 0.000 description 1
- 229910000514 dolomite Inorganic materials 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 238000005553 drilling Methods 0.000 description 1
- 229960001484 edetic acid Drugs 0.000 description 1
- 239000003974 emollient agent Substances 0.000 description 1
- 230000002708 enhancing effect Effects 0.000 description 1
- XJRPTMORGOIMMI-UHFFFAOYSA-N ethyl 2-amino-4-(trifluoromethyl)-1,3-thiazole-5-carboxylate Chemical compound CCOC(=O)C=1SC(N)=NC=1C(F)(F)F XJRPTMORGOIMMI-UHFFFAOYSA-N 0.000 description 1
- 238000001704 evaporation Methods 0.000 description 1
- 230000008020 evaporation Effects 0.000 description 1
- 125000005313 fatty acid group Chemical group 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 235000021323 fish oil Nutrition 0.000 description 1
- 238000005187 foaming Methods 0.000 description 1
- 239000000446 fuel Substances 0.000 description 1
- 230000000855 fungicidal effect Effects 0.000 description 1
- 239000000417 fungicide Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 235000011187 glycerol Nutrition 0.000 description 1
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 1
- 239000001087 glyceryl triacetate Substances 0.000 description 1
- 235000013773 glyceryl triacetate Nutrition 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N glycine betaine Chemical group C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 210000004349 growth plate Anatomy 0.000 description 1
- FUZZWVXGSFPDMH-UHFFFAOYSA-N hexanoic acid Chemical compound CCCCCC(O)=O FUZZWVXGSFPDMH-UHFFFAOYSA-N 0.000 description 1
- 150000002431 hydrogen Chemical class 0.000 description 1
- 238000005984 hydrogenation reaction Methods 0.000 description 1
- 230000002779 inactivation Effects 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000005764 inhibitory process Effects 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- SUMDYPCJJOFFON-UHFFFAOYSA-N isethionic acid Chemical class OCCS(O)(=O)=O SUMDYPCJJOFFON-UHFFFAOYSA-N 0.000 description 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 239000012939 laminating adhesive Substances 0.000 description 1
- 239000004816 latex Substances 0.000 description 1
- 229920000126 latex Polymers 0.000 description 1
- 239000000787 lecithin Substances 0.000 description 1
- 235000010445 lecithin Nutrition 0.000 description 1
- 229940067606 lecithin Drugs 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000003211 malignant effect Effects 0.000 description 1
- 239000004579 marble Substances 0.000 description 1
- 235000012054 meals Nutrition 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 238000005555 metalworking Methods 0.000 description 1
- 229920000609 methyl cellulose Polymers 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 239000003595 mist Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 230000003472 neutralizing effect Effects 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 239000003973 paint Substances 0.000 description 1
- 239000003346 palm kernel oil Substances 0.000 description 1
- 235000019865 palm kernel oil Nutrition 0.000 description 1
- 239000002540 palm oil Substances 0.000 description 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-N palmitic acid group Chemical group C(CCCCCCCCCCCCCCC)(=O)O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 1
- 239000000123 paper Substances 0.000 description 1
- 239000011236 particulate material Substances 0.000 description 1
- 235000011837 pasties Nutrition 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 235000020030 perry Nutrition 0.000 description 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 1
- 239000008363 phosphate buffer Substances 0.000 description 1
- 239000011120 plywood Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000642 polymer Polymers 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
- 238000001556 precipitation Methods 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- ULWHHBHJGPPBCO-UHFFFAOYSA-N propane-1,1-diol Chemical class CCC(O)O ULWHHBHJGPPBCO-UHFFFAOYSA-N 0.000 description 1
- RUOJZAUFBMNUDX-UHFFFAOYSA-N propylene carbonate Chemical compound CC1COC(=O)O1 RUOJZAUFBMNUDX-UHFFFAOYSA-N 0.000 description 1
- 150000003856 quaternary ammonium compounds Chemical class 0.000 description 1
- 235000009566 rice Nutrition 0.000 description 1
- 238000011012 sanitization Methods 0.000 description 1
- 238000007127 saponification reaction Methods 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 239000000565 sealant Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 229940095696 soap product Drugs 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 229940079827 sodium hydrogen sulfite Drugs 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 229940057950 sodium laureth sulfate Drugs 0.000 description 1
- GNBVPFITFYNRCN-UHFFFAOYSA-M sodium thioglycolate Chemical compound [Na+].[O-]C(=O)CS GNBVPFITFYNRCN-UHFFFAOYSA-M 0.000 description 1
- 229940046307 sodium thioglycolate Drugs 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 235000013599 spices Nutrition 0.000 description 1
- 125000001424 substituent group Chemical group 0.000 description 1
- 229910021653 sulphate ion Inorganic materials 0.000 description 1
- 239000002600 sunflower oil Substances 0.000 description 1
- 239000000516 sunscreening agent Substances 0.000 description 1
- 239000002352 surface water Substances 0.000 description 1
- 230000004083 survival effect Effects 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 239000003784 tall oil Substances 0.000 description 1
- 239000012085 test solution Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 229960000790 thymol Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 229960002622 triacetin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- 229960003500 triclosan Drugs 0.000 description 1
- 239000006150 trypticase soy agar Substances 0.000 description 1
- 108010050327 trypticase-soy broth Proteins 0.000 description 1
- 239000012137 tryptone Substances 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
- 239000008158 vegetable oil Substances 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000004065 wastewater treatment Methods 0.000 description 1
- 238000009941 weaving Methods 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
- 239000012138 yeast extract Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/02—Acyclic compounds
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/05—Phenols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Plant Pathology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- Dentistry (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Insects & Arthropods (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Cosmetics (AREA)
Abstract
A synergistic microbicidal composition containing: (a) at least one microbicide selected from the group consisting of isopropyl methyl phenols and monosubstitutedphenols and (b) at least antimicrobial alcohol is selected from the class consisting of acyclic terpene alcohols.
Description
The present invention relates to there is the synergistic combination than the microbicide of the selection of the greater activity of observing on independent microbicide.
It relates in particular to the Synergistic microbicidal compositions for personal cleanliness, mouth care or hard-surface cleaning or industry and mechanism's clean applications.
In some cases, because commercially available microbicide is for example, to the activity of the microorganism of some kind (microorganism some microbicides to resistance) very poor, or due to violent environmental condition, even at high working concentration, described commercially available microbicide also cannot provide effective control of microorganisms.
For example, the sterilization and the disinfectant soap composition that comprise antimicrobial such as the triclosan based on chlorine are known.Such composition need to be quite long time of contact effective anti-microbial effect is provided.In practice, user, particularly children, can not spend and clean for a long time, and result is used the clean of such composition do not have effects on surface or local infection to be provided in enough preventions or enough disease-resistant protections are provided.User, although cleaned his hand, probably the degerming on his skin is relative deficiency conventionally.Therefore, he may cause the other pollution that has life and/or do not have lived surface, contributes to pathogene diffusion and disease subsequently.Common user, and particularly in the risk of children's (they are cleaning the hand of pollution within the relatively short time with the antimicrobial compositions of slowly effect before the meal) in catching.
Similarly, in hard-surface cleaning field, floor for example, during desktop or utensil are clean, the antimicrobial in composition is less than a few minutes with contacting of substrate, thereafter this surface water wiping or flushing.The cleaning action of these short time range is invalid providing aspect the benefit of expectation, because be generally used for the microorganism killing effect that most of known antimicrobial in this series products needs provide to a few hours for many minutes expectation.
So, a kind of composition need to be provided, it during relatively short cleaning time, preferably approximately 30 seconds or still less, can provide relatively more effective anti-microbial effect after using.
Sometimes with the combination of different microbicides, in special final applied environment, provide the overall control of microorganism.
For example, WO2010/046238 discloses the combination of thymol and terpineol.But, need to for various microbial strains, there is the combination of extra microbicide of the snap action activity of raising, so that the effective control to microorganism to be provided.In addition, the consideration for safety, environment, attractive in appearance and economic benefit, need to contain the combination of the independent microbicide of reduced levels.Problem solved by the invention is to provide the extra combination of this type of microbicide.
Summary of the invention
The present invention relates to synergistic microbicidal compositions, it comprises: (a) be selected from 3,7-dimethyl-octa-1,6-dien-3-ols, (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol, and cis-3,7-dimethyl-2, at least one microbicide of 6-octadiene-1-alcohol; (b) be selected from least one microbicide of 5-isopropyl-2-methylphenol, 3-isopropyl-5-methylphenol, 4-isopropyl-3-methylphenol, (E)-2-(third-1-thiazolinyl) phenol, 4-propylphenol, 2-TBP, 2-sec-butyl phenol, 2-n-pro-pyl phenol, 3-n-pro-pyl phenol, 4-normal-butyl phenol, 4-sec-butyl phenol and 3-tert-butyl phenol.
Detailed Description Of The Invention
As used herein, unless context clearly demonstrates in addition, following term has the implication of indication.Term " microbicide " refers to can be at the compound of a certain region killing microorganisms, inhibition growth of microorganism or control growth of microorganism; Microbicide comprises bactericide, fungicide and algicide.Term " microorganism " comprises for example fungi (such as yeast and mould), bacterium and algae.Abbreviation below using in whole specification: mL=milliliter, ATCC=American type culture collection (American Type Culture Collection), and MBC=minimum substrate concentration of killing livestock.Unless otherwise indicated, the unit of temperature be degree Celsius (℃), percentage is (wt%) by weight percentage.
Find unexpectedly, composition of the present invention provides the microbicidel efficiency of raising with the combined activity composition level of the microbicide lower than independent.In described composition, can exist exceed claim in listed extra microbicide.
The invention provides Synergistic antimicrobial compositions, it comprises phenolic compound and antimicrobial alcohol, preferably terpene alcohol.Phenolic compound is preferably selected from isopropyl methyl phenol and single-substituted phenols.Antimicrobial alcohol is preferably selected from without cyclic terpene alcohols.
As the claimed compound of combination and the kind under them, provide as follows in the present invention:
Without cyclic terpene alcohols:
3,7-dimethyl-octa-1,6-dien-3-ols (linalool)
(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol (geraniol)
Cis-3,7-dimethyl-2,6-octadiene-1-alcohol (nerol)
Isopropyl methyl phenol:
5-isopropyl-2-methylphenol
3-isopropyl-5-methylphenol
4-isopropyl-3-methylphenol
Mono-substituted phenol:
(E)-2-(third-1-thiazolinyl) phenol,
4-propylphenol,
2-TBP,
2-sec-butyl phenol,
2-n-pro-pyl phenol,
3-n-pro-pyl phenol,
4-normal-butyl phenol,
4-sec-butyl phenol,
3-tert-butyl phenol.
Single-substituted phenols has following structure conventionally
Wherein
Substituent R
1be selected from:
Straight chain C
3-C
5alkyl,
Isopropyl
Side chain C
4alkyl,
Straight chain C
3-C
5thiazolinyl,
Straight chain C
4or C
5dialkylene (alkadienyl),
Side chain C
4thiazolinyl,
Cyclopenta,
Cyclopentenyl,
Cyclohexyl,
Cyclohexenyl group,
Phenyl, and
Benzyl.
Isopropyl-methyl-phenol has following structure conventionally
with
Without cyclic terpene alcohol, there is following structure:
，
R wherein
1, R
2and R
3be selected from hydrogen and hydroxyl, wherein lucky R
1, R
2and R
3one of be hydroxyl, condition is if key (a) is two keys, does not have R
3.Key (a) and (b) and (c) be singly-bound or two key, wherein to multikey (a) and (b) be one of (c) two keys, and the wherein said pair of key and oh group non-conterminous.Therefore, if R for example
1be selected as oh group, R
2and R
3be hydrogen, key (b) is singly-bound, and key (a) and (c) can be singly-bound or can be one of (a) and (c) two keys.
In phenolic compound, particularly preferably 2-n-pro-pyl phenol, 4-normal-butyl phenol and 4-sec-butyl phenol, because they are evaluated as for using in the consumer goods safer by the inventor.All antimicrobial alcohol of asking for protection is 3; 7-dimethyl-octa-1; 6-dien-3-ols (linalool); (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol (geraniol); and cis-3; 7-dimethyl-2,6-octadiene-1-alcohol (nerol) is all preferred, because they are evaluated as use in the consumer goods by the inventor, is safe.
In preferred embodiments, described Synergistic antimicrobial compositions comprises and is selected from (a) 3,7-dimethyl-octa-1,6-dien-3-ols (linalool), (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol (geraniol) and cis-3,7-dimethyl-2, at least one microbicide of 6-octadiene-1-alcohol (nerol) and (b) be selected from least one microbicide of 2-n-pro-pyl phenol, 4-normal-butyl phenol and 4-sec-butyl phenol.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 5-isopropyl-2-methylphenol and 3,7-dimethyl-octa-1,6-dien-3-ols (also referred to as linalool).Preferably, 5-isopropyl-2-methylphenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.4 to 1/31.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-isopropyl-5-methylphenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 3-isopropyl-5-methylphenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/2.5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-isopropyl-3-methylphenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 4-isopropyl-3-methylphenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.05 to 1/2.5, preferably 1/0.05 to 1/0.13 or 1/0.17 to 1/2.5, preferably 1/0.17 to 1/2.5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises (E)-2-(third-1-thiazolinyl) phenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, (E)-2-(third-1-thiazolinyl) phenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.04 to 1/2.5, preferably 1/0.04 to 1/0.13 or 1/0.83 to 1/2.5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-propylphenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 4-propylphenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.38 to 1/3.1.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-n-pro-pyl phenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 2-n-pro-pyl phenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.1 to 1/2.5, preferably 1/0.19 to 1/2.5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-n-pro-pyl phenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 3-n-pro-pyl phenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.13 to 1/4.2, preferably 1/0.13 to 1/0.17 or 1/0.25 to 1/4.2, preferably 1/0.25 to 1/4.2.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-normal-butyl phenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 4-normal-butyl phenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.5 to 1/3.1.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-tert-butyl phenol and 3,7-dimethyl-octa-1,6-dien-3-ols.Preferably, 3-tert-butyl phenol and 3,7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.13 to 1/4.2.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 5-isopropyl-2-methylphenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol (also referred to as
Geraniol).Preferably, 5-isopropyl-2-methylphenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.05 to 1/33, preferably 1/0.25 to 1/33.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-isopropyl-5-methylphenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 3-isopropyl-5-methylphenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.08 to 1/20, preferably 1/2.5 to 1/20.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-isopropyl-3-methylphenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 4-isopropyl-3-methylphenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/1 to 1/2.4.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises (E)-2-(third-1-thiazolinyl) phenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, (E)-2-(third-1-thiazolinyl) phenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.03 to 1/6.7, preferably 1/0.08 to 1/0.15 or 1/0.19 to 1/0.5, or 1/1 to 1/6.7.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-propylphenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 4-propylphenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.25 to 1/33, preferably 1/3.3 to 1/33.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-TBP and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 2-TBP and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.5 to 1/8, preferably 1/0.5 to 1/4.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-sec-butyl phenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 2-sec-butyl phenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/2 to 1/16, preferably 1/4 to 1/16.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-n-pro-pyl phenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 2-n-pro-pyl phenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.4 to 1/20, preferably 1/0.4 to 1/16, preferably 1/0.4 to 1/4 or 1/6 to 1/16.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-n-pro-pyl phenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 3-n-pro-pyl phenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.06 to 1/33, preferably 1/0.17 to 1/33, preferably 1/0.17 to 1/0.25 or 1/0.38 to 1/33.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-normal-butyl phenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 4-normal-butyl phenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.25 to 1/25, preferably 1/0.25 to 1/1 or 1/5 to 1/25.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-tert-butyl phenol and (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol.Preferably, 3-tert-butyl phenol and (E)-3,7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is about 1/8.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 5-isopropyl-2-methylphenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol (also referred to as nerol).Preferably, 5-isopropyl-2-methylphenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.08 to 1/0.5, preferably 1/0.25 to 1/0.5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-isopropyl-5-methylphenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 3-isopropyl-5-methylphenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.06 to 1/0.38.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-isopropyl-3-methylphenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 4-isopropyl-3-methylphenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.13 to 1/0.38, preferably 1/0.13 to 1/0.25.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises (E)-2-(third-1-thiazolinyl) phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, (E)-2-(third-1-thiazolinyl) phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.04 to 1/0.33, preferably 1/0.19 to 1/0.33.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-propylphenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 4-propylphenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.08 to 1/5, preferably 1/0.25 to 1/5, preferably 1/0.25 to 1/1 or 1/2.5 to 1/5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-TBP and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 2-TBP and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/3.3 to 1/6.7, preferably 1/4 to 1/6.7.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-sec-butyl phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 2-sec-butyl phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/5 to 1/150, preferably 1/6 to 1/150.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 2-n-pro-pyl phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 2-n-pro-pyl phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.13 to 1/2.5, preferably 1/0.25 to 1/2.5.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-n-pro-pyl phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 3-n-pro-pyl phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.06 to 1/3.3, preferably 1/0.17 to 1/3.3, preferably 1/0.17 to 1/0.25 or 1/0.5 to 1/3.3.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-normal-butyl phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 4-normal-butyl phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.25 to 1/3.3, preferably 1/0.25 to 1/1.25.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 4-sec-butyl phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 4-sec-butyl phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/1 to 1/3.3, preferably 1/1 to 1/1.25.
In a preferred embodiment of the invention, Synergistic antimicrobial compositions comprises 3-tert-butyl phenol and cis-3,7-dimethyl-2,6-octadiene-1-alcohol.Preferably, 3-tert-butyl phenol and cis-3,7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.13 to 1/6.7, preferably 1/0.13 to 1/0.38 or 1/3.3 to 1/6.7, preferably 1/3.3 to 1/6.7.
According to combination of the present invention, can there is very fast anti-microbial effect.For example, we find, in most of the cases, bacteria inactivation rate can be used composition according to the present invention realization after time of contact of 15 seconds only completely.
Microbicide in the present composition can be used " same as before ", or can first use solvent or solid carrier preparation.Suitable solvent comprises for example water; Dihydroxylic alcohols, such as ethylene glycol, propane diols, diethylene glycol, dipropylene glycol, polyethylene glycol and polypropylene glycol; Glycol ethers; Alcohol, such as methyl alcohol, ethanol, propyl alcohol, benzyl carbinol and phenoxypropanol; Ketone, such as acetone and methyl ethyl ketone; Ester, such as ethyl acetate, butyl acetate, triacetyl citrate (triacetyl citrate) and glyceryl triacetate; Carbonic ester, such as propylene carbonate and dimethyl carbonate; Inorganic particulate material, starch, air and composition thereof.In certain preferred aspects, suitable solvent comprises for example water, dihydroxylic alcohols, glycol ethers, ester and composition thereof.Suitable solid carrier comprises for example cyclodextrin, silica, clay, talcum, calcite, dolomite, alumino-silicate, diatomite, wax, cellulosic material, alkali and alkaline earth metal ions (for example sodium, magnesium, potassium) slaine (for example chloride, nitrate, bromide, sulphate) and charcoal.
Particularly preferred carrier is water or oil/solvent, even more preferably as the carrier of water and oily mixture.The example of oil comprises mineral oil, the oil of biogenetic derivation (for example vegetable oil), and oil and the wax in oil source.The oil of biogenetic derivation is preferably based on triglycerides.Preferably, carrier oil is not aromatic oil.Therefore, carrier oil is the essentially no smell that helps composition preferably, and more preferably it is helpless to this smell.The example of solvent comprises alcohol, ether and acetone.Starch can be available from the native starch of food grain or can be modified starch.
When component according to the present invention and/or terpineol is atomized or while being otherwise separated into mist, air can for example be used as carrier.
Particularly preferred carrier is water or oil/solvent, even more preferably as the carrier of water and oily mixture.Therefore, the application of many expections as personal nursing/cleaning, mouth care and hard-surface cleaning in, antimicrobial compositions can be with aqueous base or the preparation of oil/solvent base-material.The composition with aqueous base (water is carrier) can also be for example the product of gel form.The composition with oil/solvent base-material can be for example the product of anhydrous bar form or the product that contains propellant.
Therefore, antimicrobial compositions can, for example, the antimicrobial anhydrous excellent personal care composition on oil/solvent base-material preferably, wherein said composition has the water content that is less than 0.01 % by weight, and wherein said composition is preferably not moisture.Or antimicrobial compositions can for example, be preferably the drivable personal care composition of antimicrobial propellant that also comprises propellant.Air also can be used as propellant, for example, with compression or the form of liquefied air.
Yet most preferred product form can form emulsion after having emulsion binder (water and/or oil are carriers) or dilution, the soap product of liquid, solid, washing lotion or the semi-solid form of for example applying for washing one's hands, wash one's face, have a bath or shaving; For the toothpaste/tooth powder of mouth care application or for the strip of hard-surface cleaning or the product of liquid form.As fruit product comprises emulsion base-material, it preferably also contains one or more surfactants as described below.
" do not basically contain " and refer to; for example; weight based on active component (; claimed component a) and b) add the weight of the additional component of listing in this paragraph) have and be less than 5 % by weight; preferably be less than 3 % by weight; preferably be less than 1 % by weight, be preferably less than 0.5 % by weight, be preferably less than 0.2 % by weight.
When microbicide component is prepared with solvent, said preparation can optionally comprise surfactant.When this type of preparation comprises surfactant, they can be the forms of emulsion concentrates, emulsion, microemulsion concentrates or microemulsion.Emulsion concentrates forms emulsion after adding enough water.Microemulsion concentrates forms microemulsion after adding enough water.This type of emulsion and microemulsion concentrates are normally well-known in the art.Can be referring to U.S. Patent number 5,444,078 about preparing the more extensive and concrete details of various microemulsions and microemulsion concentrates.
Preferred product form has emulsion binder (water and/or oil are as carrier), or can after dilution, form emulsion, the soap series products of liquid, solid, washing lotion or the semi-solid form of for example applying for washing one's hands, wash one's face, have a bath or shaving; For the toothpaste/tooth powder of mouth care application or the product for hard surface cleaning of strip or liquid form.As fruit product comprises emulsion binder, it preferably also contains one or more surfactants as described below.
Particularly preferably be, in the present invention the synergistic combination of claimed microbicide, one or more surfactants that Synergistic microbicidal compositions comprises 1 to 80 % by weight.
Conventionally, this surfactant can be selected from the surfactant described in well-known textbook, described well-known textbook is as " Surface Active Agents " the 1st volume, Schwartz & Perry, lnterscience 1949, the 2nd volume, Schwartz, Perry & Berch, Interscience 1958, and/or " the McCutcheon's Emulsifiers and Detergents " of the current version of being published by Manufacturing Confectioners Company or at " Tenside-Taschenbuch ", H.Stache, the 2nd edition, Carl Hauser Verlag, in 1981, " Handbook of Industrial Surfactants " (the 4th edition) Michael Ash and Irene Ash, Synapse Information Resources, 2008.Can use the surfactant of any type, i.e. the surfactant of anionic, cationic, nonionic, amphoteric ion type or amphoteric.Preferably, one or more surfactants are anionic surfactant, nonionic surface active agent, or the combination of anionic and nonionic surface active agent.More preferably, one or more surfactants are anionics.
Particularly preferred surfactant is soap.Soap be a kind of for the individual Cleaning application of antimicrobial compositions of the present invention suitable surfactant.This soap is C preferably
8– C
24soap, more preferably C
10– C
20soap and most preferably C
12– C
16soap.This soap can have or can not have one or more carbon-to-carbon double bonds or triple bond.The cation of this soap can be for example alkali metal, alkaline earth metal or ammonium.Preferably, the cation of this soap is selected from sodium, potassium or ammonium.More preferably the cation of this soap is sodium or potassium.
This soap can obtain by the saponification of fat and/or fatty acid.Fat or oil can be to be generally used for the fat of soap in manufacturing or oily, such as animal fat (tallow), animal fat tristearin (tallow stearines), palm oil, palm stearin, soybean oil, fish oil, castor oil, rice bran oil, sunflower oil, cocoa butter, babassu oil, palm-kernel oil, etc.In said method, fatty acid stems from the oil/fat being selected from below: coconut, rice bran, peanut, animal fat, palm, palm kernel, cottonseed, soybean, castor-oil plant etc.Fatty acid soaps can be also synthetic preparation (for example, by the oxidation of oil or by the Fischer-Tropsch process hydrogenation of carbon monoxide).Can use resin acid, such as being present in those in tall oil.Naphthenic acid is also suitable.
Animal fat fatty acid can stem from various animal origins.Also comprise other similar mixture, such as come from palmitic those and come from those of various animal tallows and lard.
Typical fatty acid blend is comprised of the coconut fatty acid of 5-30%-wt and the fatty acid that takes self-hardening rice bran oil of 70-95%-wt.The fatty acid that stems from other suitable oil/fat such as peanut, soybean, animal fat, palm, palm kernel etc. also can be used with other required ratio.Described soap is when existing with solid form of the present invention, and its amount is the 30-80 % by weight of said composition preferably, more preferably 50-80 % by weight, even more preferably 55-75 % by weight.Described soap is when the liquid form with composition exists, and amount is the 0.5-20 % by weight of said composition preferably, more preferably 1-10 % by weight.
Other preferred surfactant is fatty acid glycinate and fatty both sexes yl carboxylic acid salt.These surfactants are particularly preferred in skin and hair Cleasing compositions, because their gentle soil release performance and high-foaming character.Fatty acid glycinate is the salt of the fatty acid amide of glycine, comprises for example cocoyl Sodium Glycinate.Fat both sexes yl carboxylic acid salt is amphoteric surfactant, for example comprises bay both sexes guanidine-acetic acid sodium (that is, 2-[1-(2-hydroxyethyl)-2-undecyl-4,5-glyoxalidine-1--1-yl] sodium acetate).The another kind of example again of suitable surfactant is the derivative of isethionate, comprises acyl isethinate.
Antimicrobial compositions of the present invention is also useful in hard-surface cleaning application.In this type of application, when product is liquid form, preferred surfactant is nonionic surface active agent, such as C
8– C
22, preferred C
8– C
16aliphatic alcohol ethyl oxide, comprises 1-8 ethylene oxide group.When this product is solid form for hard-surface cleaning application, surfactant is preferably selected from the alkyl sulfate of primary alkyl sulphates, secondary alkyl sulfonate, alkylbenzenesulfonate, ethoxyquin or the nonionic surface active agent of alcohol ethoxyquin.Said composition can further comprise anionic surfactant, such as alkyl ether sulfate, preferably has those of 1-3 ethylene oxide group, and it comes from natural or synthetic source and/or sulfonic acid.Particularly preferably be sodium laureth sulfate.Alkyl poly glucoside also may reside in said composition, those that preferred carbon chain lengths is C6-C16.The useful surfactant of other type comprises cationic surface active agent, such as long chain quaternary ammonium compound and amphoteric surfactant such as betaines and alkyl dimethyl amine oxide.In the hard-surface cleaning application of liquid form, suitable surfactant concentration is the approximately 0.5-10 % by weight of composition normally, preferably 1-5 % by weight.In solid composite, the preferred amount of surfactant is the 5-40 % by weight of composition, preferably 10-30 % by weight.
Antimicrobial compositions of the present invention is for example useful in tooth powder/toothpaste or in the product of gargling in oral care composition.In this type of application, preferred surfactant is anionic, nonionic or amphoteric in nature, preferred anionic type or amphoteric.Anionic surfactant is alkali metal alkyl sulfate preferably, is more preferably NaLS (SLS).Also can use the mixture of anionic surfactant.Amphoteric surfactant is betain preferably, and more preferably (wherein this alkyl is the C of straight chain to alkylamidoalkyl CAB
10– C
18chain), cocamidopropyl betaine (CAPB) most preferably.Also can use the mixture of amphoteric surfactant.In mouth care application, suitable surfactant concentration is approximately 2 % by weight-Yue 15 % by weight of total composition normally, preferably approximately 2.2 % by weight-Yue 10 % by weight, more preferably from about 2.5-approximately 5 % by weight.
Therefore, it is highly preferred that this antimicrobial compositions comprises that soap, alkyl sulfate or linear alkylbenzene sulfonate (LAS) are as surfactant.More preferably, one or more surfactants are selected from soap, alkyl sulfate and linear alkylbenzene sulfonate (LAS).
Can also be with the form preparation microbicide component of dispersion.The solvent composition of dispersion can be organic solvent or water, preferred water.This type of dispersion can comprise adjuvant, for example cosolvent, thickener, antifreezing agent, dispersant, filler, pigment, surfactant, bio-dispersant, polycation, stabilizing agent, fouling inhibitor and anticorrosive additive.
When first two kinds of microbicides are all prepared with solvent separately, can be identical or different with the solvent that is used for preparing another kind of commercially available microbicide for the solvent of the first microbicide, although preferred water is for the application of most industry biocide.Preferably, these two kinds of solvents are miscible.
Said composition can further comprise various extra composition well known by persons skilled in the art.This type of extra composition includes but not limited to: spices, pigment, preservative, emollient, sun-screening agent, emulsifier, gelating agent, thickener, wetting agent (for example glycerine, sorbierite), chelating agent (for example EDTA) or polymer (for example, for structurized cellulose derivatives, such as methylcellulose).
This antimicrobial compositions can be the form of solid, liquid, gel or pasty state.Those skilled in the art can be by selecting one or more carrier materials and/or surfactant to prepare various forms of compositions.Antimicrobial compositions of the present invention, for clean and nursing, is particularly useful for skin clean and skin nursing.Can expect that this antimicrobial compositions can be used as leave (leave-on) product or use rear rinse-off products, preferably uses rear rinse-off products.Antimicrobial compositions of the present invention can also be for crust such as glass, metal, the clean and nursing of plastics etc.
Those skilled in the art will recognize that, microbicide component of the present invention can be applied to region successively or simultaneously, or mix before being applied to this region.Preferably, by the first microbicide and the second microbicide simultaneously or be applied to successively region.When described microbicide is simultaneously or when apply successively, every kind of independent component can comprise adjuvant, such as, for example solvent, thickener, antifreezing agent, colouring agent, chelating agent (such as ethylenediamine tetra-acetic acid, EDDS, iminodisuccinic acid and salt thereof), dispersant, surfactant, bio-dispersant, polycation, stabilizing agent, fouling inhibitor and anticorrosive additive.
Microbicide composition of the present invention can be used for by affected region, within said composition that maybe this place introduces microbicidel effective dose suppress microbial growth or killing microorganisms.
Suitable region for example comprises: industrial treatment water comprises that electropaining covers depositing system, cooling tower and air washer; Drechsel system; Wastewater treatment; Waterwork; Osmosis filtration; Ultrafiltration; Water ballast; Evaporative condenser and heat exchanger; Paper pulp and paper are processed fluid and additive; Mineral slurry; Starch; Plastics; Emulsion; Dispersion; Paint; Latex; Coating is such as varnish; Building products, such as filling up agent, pointing and sealant; Building adhesive, such as ceramic binder, carpet scrim binder and laminating adhesive; Industrial or consumption adhesive; Photographic chemicals; Printing fluids; The family using in restaurant, medical health facility, school, food processing facility and farm and mechanism's product, comprise cleaning agent, disinfectant and disinfectant, cleaning piece, soap, washing agent, floor wax and rinsing clothes water; Cosmetics; Cosmetic product; Shampoo; Metal working fluids; Conveyer belt lubricant; Hydraulic fluid; Leather and leather processing product; Fabric; Weaving and textile process product; Timber and timber converted products, such as particle board, hardboard and the flakeboard of plywood, chipboard, wallboard, particle board, laminated beam, orientation; The gentle process fluid of oil, such as injecting fluid, fracturing fluid, drilling mud and recovered water; Fuel transport and storage system; Agricultural adjuvant is preserved; Surfactant is preserved; Medical treatment device; Diagnostic reagent is preserved; Food is preserved, such as plastics or papery packaging for foodstuff; Food, beverage and industrial treatment Pasteurizer; Water closet; Recreational water; Pond; With mineral spring health resort.
In preferred embodiments, composition is particularly suitable for being applied to skin.For example, surface can contact with composition of the present invention suitably as hand, face, health or oral cavity.In other preferred embodiment, surface is any crust.Conventionally, this type of crust is conventionally to need to clean and also often need the surface of sanitized or sterilization.This type of surface can be found in a lot of family expenses or industrial environment, and can comprise for example kitchen and bathroom surfaces, desktop, floor, wall, window, cooker, tableware and bowl dish.This type of surface can be made by many different materials, for example plastics, timber, metal, pottery, glass, concrete, marble and painted surface.In preferred embodiments, described composition can be used for this type of sterilization, in the place except foregoing surface, reduces microbe quantity or improves health.
In preferred embodiments, the present invention relates to as residential care product and personal care product or mix residential care product and personal care product according to composition of the present invention.More preferably, this embodiment of the present invention relate to as residential care product or personal care product according to composition of the present invention.
" residential care product " is for the treatment of, clean, nursing or regulates the product of family or any its content.Aforementioned comprising, but be not limited to, composition, product or its combination, it relates to following or has in the following purposes or an application: the manufacture of the processing of surface, furniture and the atmosphere of family and home content (such as clothes, fabric and/or measuring fiber), cleaning, clean, nursing or adjusting and all the said goods." personal care product " be for the treatment of, clean, nurse or nurse one's health individual product.Aforementioned comprising, but be not limited to, chemicals, composition, product or its combination, it relates to following or has in the following purposes or an application: individual's's (comprising particularly skin, hair and oral cavity) processing, cleaning, clean or conditioning and all above-mentioned manufactures.Residential care product and personal care product are for example with general marketplace brand product sold, and limiting examples is soap bar, deodorant, shampoo and family's surface disinfectant/disinfectant.
According to a further aspect in the invention, provide the method for disinfecting surface, it comprises the following steps:
A. composition according to the present invention is administered on described surface; With
B. from surface, remove described composition.
The method according to this invention also comprises from the step of surface removal composition.Herein, remove composition and also comprise part removal composition, because trace composition can be from the teeth outwards residual.Under many typical case (such as washed skin or clean crust), if some active component of fruit part composition-particularly-residual is acceptable from the teeth outwards, sometimes or even expectation.Therefore, step b preferably includes removal at least 5 % by weight, more preferably at least 10 % by weight, even more preferably at least 25 % by weight, more preferably at least 50 % by weight still, and the more preferably composition of at least 75 % by weight again.Preferably, the step of removing composition comprises with suitable solvent washing surface or by suitable cleaning piece wipe surfaces, and more preferably, this step is surperficial or form by suitable cleaning piece wipe surfaces by the solvent washing with suitable.Or, remove step and also can comprise evaporation section composition, for example, for example, when composition comprises volatile component, during solvent.
For to rinse surperficial suitable media be water, but it can be also the mixture of water and alcohol for example.Then after predetermined time section, preferably with enough water, rinse, remove any visible or appreciable composition is residual.Or, can use the cleaning piece of alcohol cleaning piece or water/alcohol dipping that surface is wiped and there is no visible antimicrobial compositions.After starting, the step that the step of removing composition (for example, by flushing or wipe surfaces) is preferably used composition is from the teeth outwards less than 5 minutes, more preferably less than 2 minutes, even more preferably less than 1 minute, still more preferably less than 30 seconds, more preferably less than 20 seconds, start again, because composition according to the present invention has fast surprisingly anti-microbial effect.Even if part microorganism killing can after using according to composition of the present invention, almost moment occurs, but after the step of preferably using from the teeth outwards composition starts at least 5 seconds, preferably at least 10 seconds, more preferably at least 15 seconds start the step from surface removal composition, to realize best anti-microbial effect.By these ageings, be to be also preferred in the time interval.Therefore, particularly preferably be, the step of using from the teeth outwards composition (is that step a) starts latter 2 minutes to 5 seconds, more preferably at 1 minute to 10 seconds, even more preferably 30 to 10 seconds, still more preferably within 20 to 15 seconds, start step from surface removal composition (be step a).
disinfecting time
These times of using between composition and flushing or wiping are preferably relevant with disinfecting time, to guarantee surperficial optimal clean and sterilization.Therefore, the present invention preferably related to a kind of method, and the disinfecting time T of wherein said method is less than 300 seconds, is preferably less than 60 seconds, more preferably less than 15 seconds; Wherein T is defined as from composition being added into the moment of culture of microorganism until microbe number/unit volume culture reduces by 100 000 times of institute's elapsed times; And wherein the initial number of microorganism preferably surpasses approximately 100 000 000 microorganism/milliliters, and wherein said composition is preferably fluid composition.
The disinfective action of the method (as represented with disinfecting time T form) is preferably determined according to the scheme of embodiment as described below 1.This test relates to wherein makes culture of microorganism remain on the standardization experimental enviroment in suspension.Similar suitable test is the standard suspension process described in European standard EN1276, and condition is by disinfecting time adjustment, to adapt to clearly above-mentioned standard for those skilled in the art.Or one of test method described in WO 2010/046238 can for example be applied to establish disinfective action.
Those skilled in the art also can preferably use this type of test method to determine according to the optium concentration of one or more components in antimicrobial compositions of the present invention.
Or, because described method is for surface sterilization, so disinfecting time also can be determined by relating to surperficial test method.Therefore, the present invention preferably relates to the method according to this invention, and the surface sterilization time T 2 of wherein said method is less than 60 seconds, is preferably less than 15 seconds; Wherein T2 is defined as from composition being applied to the time that the moment on surface to be sterilized starts, and microbe number/unit are reduces by 10000 times (reducing by 4 log) thereafter; Wherein, the initial number of microorganism preferably surpasses 10
3, more preferably 10
5, even more preferably 10
7individual microorganism/square centimeter.This type of test can be for example described in WO 2010/046238, or carries out described in European standard EN 13697:2001 and EN 1500:1997.
Another preferred embodiment of the present invention relate to as industry and/or mechanism's product or mix industry and/or mechanism's product according to composition of the present invention.More preferably, this embodiment of the present invention relate to as industry and/or mechanism's product according to composition of the present invention.Industry and mechanism's product are for example with professional brand product sold, and limiting examples is for industry, mechanism, sanitation and hygiene and medical cleaning, cleaning on the spot, food service, animal doctor and agricultural products.Industry and/or mechanism's product also comprise for medical office, hospital and/or other mechanism for the clean product of people (such as hand cleanser).
In a further preferred embodiment, the invention still further relates to residential care product or personal care product's the method according to this invention or purposes.For example, Gen according to side Fa – of the present invention its be included in step a, use according to composition of the present invention-can be wherein composition be as above as residential care product and personal care product or the method for mixing residential care product and personal care product's composition.Similarly, in a further preferred embodiment, the invention still further relates to the method according to this invention or the purposes of industry and/or mechanism's product.For example, Gen according to side Fa – of the present invention its be included in step a, use according to composition of the present invention-can be wherein composition be as above as industry and/or mechanism's product or mix industry and/or the method for the composition of mechanism's product.
For the product that uses in residential care or personal care field and/or method, be conventionally different from product and/or the method for using in industry and/or field of mechanisms.Therefore, for example, as family or personal care product's product sold using conventionally not as the production marketing for industry and/or mechanism's use, vice versa.Therefore, some preferred embodiment of the present invention, when trying out, will relate to a field, and not relate to other field.
Be used for suppressing or control area in the concrete amount of the required present composition of growth of microorganism depend on specific region to be protected.Conventionally, if the present composition in region, provide described composition altogether microbicide composition 0.02 to 4%, in its control area, the amount of growth of microorganism is enough.Preferably, the amount that the microbicide composition of composition exists in this region is at least 0.05%, preferably at least 0.1%, preferably at least 0.2%, preferably at least 0.3%, preferably at least 0.4%.Preferably, the total amount that the microbicide composition of composition exists in this region, for being no more than 4%, is preferably no more than 2%, is preferably no more than 1%.
If surface is the surface of human body or animal body, the described method non-therapeutic method of disinfecting surface preferably.
Embodiment
materials and methods
By testing needle, to indicating compound concentration and the ratio of the wide region of microorganism, show the synergy of combination of the present invention.Those skilled in the art will recognize that, other microorganism to the susceptibility of particular combination by difference, and as a result of, the concentration of compound, ratio, for each or both may from these embodiment, describe in detail those are different.Concentration and ratio can also be used different tests method and difference at different tests conditioned disjunction.
Synergistic measuring is a Kull, F.C.; Eisman, P.C.; Sylwestrowicz, H.D. and Mayer, R.L. exists
applied Microbiologythe acceptable method of industry proposing in 9:538-541 (1961), the method is used the ratio of measuring by following formula:
Q
a/ Q
a+ Q
b/ Q
b=index of cooperation (" SI ")
Wherein:
Q
aduring=independent role, produce the concentration (MBC of compd A) of the compd A representing with percentage (the first component) of terminal.
Q
a=in mixture, produce the concentration of the compd A representing with percentage of terminal.
Q
bduring=independent role, produce the concentration (MBC of compd B) of the compd B representing with percentage (second component) of terminal.
Q
b=in mixture, produce the concentration of the compd B representing with percentage of terminal.
Work as Q
a/ Q
aand Q
b/ Q
bsum is greater than at 1 o'clock, illustrates and has antagonism.When their sums equal 1, illustrate and there is accumulative action, when being less than 1, illustrating and there is synergy.SI is less, and the shown synergy of specific mixture is larger.The minimum of microbicide kill livestock substrate concentration (MBC) be under one group of specified conditions, test the least concentration killed completely of test microorganism is provided.
Synergism Testing is undertaken by standard microtiter plate determination method with the phosphate buffer that contains 35% dipropylene glycol (DPG).In the method, in the situation that the component of various concentration (B) exists the high-resolution MBC test of carrying out component (A) to detect the combination of being permitted multi-chemical.High-resolution MBC measures by following steps: the microbicide to adding various amounts in a row microtiter plate, by automated fluid operating system, carry out 10 times of serial dilutions, and obtain a series of compact arranged end points.MBC plate is once inoculated to row with test microorganism.The aliquot in inoculation hole was transferred to the plate that contains neutralizer (D/E neutralising fluid medium) at 15 seconds, mixes and keep 5 minutes, be then transferred to the growth plate that contains trypticase soybean liquid nutrient medium (TSB).TSB plate is hatched at 37 ℃, and the presence/absence of read in 24 hours time growth.It is the minimum substrate concentration of killing livestock (MBC) that the floor level of the test of killing (as not growth in microtiter plate proves) completely of test organism body in 15 seconds is provided.
At approximately 1 x 10
8the concentration of individual bacterium/mL, directed toward bacteria Escherichia coli (Escherichia coli-ATCC #10536) are measured the synergy of combination of the present invention.This microorganism has represented the natural contamination in many consumers and commercial Application.37 ℃ hatch 24 hours after the growth of microorganism (turbidity) of visual assessment plate to determine MBC.
The synergistic result of the test that shows combination of the present invention is presented in following table 1-32.Each table has shown the concrete combination of two kinds of components; Result for the microorganism of testing; For the first independent component (Q
a), for independent second component (Q
b), for the first component (Q in mixture
a) and for the second component (Q in mixture
b) terminal representing with % by weight measured by MBC is active; The SI value of calculating; Collaborative proportion (the first component/second component or A/B) with various test combinations for specified microorganisms.
Data in following table comprise the proportion that is found collaborative.(report is not equal to or greater than Q for concentration wherein
aor Q
bthe combination data of collecting).These data show, some combination of component A and B shows such as fruit combination is the cumulative but not collaborative desired control to the enhancing of microorganism.
table 1
The first component (A)=5-isopropyl-2-methylphenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
5-isopropyl-2-methylphenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.5-isopropyl-2-methylphenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.4 to 1/3.1.
table 2
The first component (A)=3-isopropyl-5-methylphenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
3-isopropyl-5-methylphenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.3-isopropyl-5-methylphenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/2.5.
table 3
The first component (A)=4-isopropyl-3-methylphenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
4-isopropyl-3-methylphenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.4-isopropyl-3-methylphenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.05 to 1/2.5.
table 4
The first component (A)=(E)-2-(third-1-thiazolinyl) phenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
(E)-2-(third-1-thiazolinyl of test) phenol and 3,7-dimethyl-octa-1, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.(E)-2-(third-1-thiazolinyl) phenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.04 to 1/2.5.
table 5
The first component (A)=4-propylphenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
4-propylphenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.4-propylphenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.38 to 1/3.1.
table 6
The first component (A)=2-n-pro-pyl phenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
2-n-pro-pyl phenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.2-n-pro-pyl phenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.1 to 1/2.5.
table 7
The first component (A)=3-n-pro-pyl phenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
3-n-pro-pyl phenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.3-n-pro-pyl phenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.13 to 1/4.2.
table 8
The first component (A)=4-normal-butyl phenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
4-normal-butyl phenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.4-normal-butyl phenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.5 to 1/3.1.
table 9
The first component (A)=3-tert-butyl phenol
Second component (B)=3,7-dimethyl-octa-1,6-dien-3-ols
3-tert-butyl phenol and 3,7-dimethyl-octa-1 of test, the proportion of 6-dien-3-ols is 1/0.025 to 1/350.3-tert-butyl phenol and 3,7-dimethyl-octa-1, the collaborative proportion of 6-dien-3-ols is 1/0.13 to 1/4.2.
table 10
The first component (A)=5-isopropyl-2-methylphenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
5-isopropyl-2-methylphenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/250.5-isopropyl-2-methylphenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.05 to 1/33.
table 11
The first component (A)=3-isopropyl-5-methylphenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
3-isopropyl-5-methylphenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/250.3-isopropyl-5-methylphenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.08 to 1/20.
table 12
The first component (A)=4-isopropyl-3-methylphenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
4-isopropyl-3-methylphenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/200.4-isopropyl-3-methylphenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/1 to 1/2.4.
table 13
The first component (A)=(E)-2-(third-1-thiazolinyl) phenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
(E)-2-(third-1-thiazolinyl of test) phenol and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/250.(E)-2-(third-1-thiazolinyl) phenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.03 to 1/6.7.
table 14
The first component (A)=4-propylphenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 4-propylphenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/250.4-propylphenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.25 to 1/33.
table 15
The first component (A)=2-TBP
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 2-TBP of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/300.2-TBP and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.5 to 1/8.
table 16
The first component (A)=2-sec-butyl phenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 2-sec-butyl phenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/300.2-sec-butyl phenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/2 to 1/16.
table 17
The first component (A)=2-n-pro-pyl phenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 2-n-pro-pyl phenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/300.2-n-pro-pyl phenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.4 to 1/20.
table 18
The first component (A)=3-n-pro-pyl phenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 3-n-pro-pyl phenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/250.3-n-pro-pyl phenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.06 to 1/33.
table 19
The first component (A)=4-normal-butyl phenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 4-normal-butyl phenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/250.4-normal-butyl phenol and (E)-3,7-dimethyl-octa-2, the collaborative proportion of 6-diene-1-alcohol is 1/0.25 to 1/25.
table 20
The first component (A)=3-tert-butyl phenol
Second component (B)=(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol
The 3-tert-butyl phenol of test and (E)-3,7-dimethyl-octa-2, the proportion of 6-diene-1-alcohol is 1/0.025 to 1/300.3-tert-butyl phenol and (E)-3,7-dimethyl-octa-2, the collaborative ratio of 6-diene-1-alcohol is 1/8.
table 21
The first component (A)=5-isopropyl-2-methylphenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
5-isopropyl-2-methylphenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/350.5-isopropyl-2-methylphenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.08 to 1/0.5.
table 22
The first component (A)=3-isopropyl-5-methylphenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
3-isopropyl-5-methylphenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/350.3-isopropyl-5-methylphenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.06 to 1/0.38.
table 23
The first component (A)=4-isopropyl-3-methylphenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
4-isopropyl-3-methylphenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/350.4-isopropyl-3-methylphenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.13 to 1/0.38.
table 24
The first component (A)=(E)-2-(third-1-thiazolinyl) phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
(E)-2-(third-1-thiazolinyl of test) phenol and cis-3,7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/350.(E)-2-(third-1-thiazolinyl) phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.04 to 1/0.33.
table 25
The first component (A)=4-propylphenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
4-propylphenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.4-propylphenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.08 to 1/5.
table 26
The first component (A)=2-TBP
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
2-TBP and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.2-TBP and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/3.3 to 1/6.7.
table 27
The first component (A)=2-sec-butyl phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
2-sec-butyl phenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.2-sec-butyl phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/5 to 1/150.
table 28
The first component (A)=2-n-pro-pyl phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
2-n-pro-pyl phenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.2-n-pro-pyl phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.13 to 1/2.5.
table 29
The first component (A)=3-n-pro-pyl phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
3-n-pro-pyl phenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.3-n-pro-pyl phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.06 to 1/3.3.
table 30
The first component (A)=4-normal-butyl phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
4-normal-butyl phenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.4-normal-butyl phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.25 to 1/3.3.
table 31
The first component (A)=4-sec-butyl phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
4-sec-butyl phenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.4-sec-butyl phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/1 to 1/3.3.
table 32
The first component (A)=3-tert-butyl phenol
Second component (B)=cis-3,7-dimethyl-2,6-octadiene-1-alcohol
3-tert-butyl phenol and cis-3 of test, 7-dimethyl-2, the proportion of 6-octadiene-1-alcohol is 1/0.025 to 1/250.3-tert-butyl phenol and cis-3,7-dimethyl-2, the collaborative proportion of 6-octadiene-1-alcohol is 1/0.13 to 1/6.7.
Tested following Synergistic microbicidal compositions and found and do not worked in coordination with: 3-isopropyl-5-methylphenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 4-isopropyl-3-methylphenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; The 2-tert-butyl group-5-methylphenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 2-sec-butyl phenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 4-normal-butyl phenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 4-amyl phenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 3-isopropyl-5-methylphenol and (1R, 2S, 5R)-5-methyl-2-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; The 2-tert-butyl group-5-methylphenol and (1R, 2S, 5R)-5-methyl-2-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 4-amyl phenol and (1R, 2S, 5R)-5-methyl-2-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 3-n-pro-pyl phenol and acetic acid (1S, 2S, 5R)-2-isopropyl-5-methyl cyclohexyl of the weight ratio test with 1/0.025 to 1/1100; 2-n-pro-pyl phenol and propionic acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; 3-n-pro-pyl phenol and propionic acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; 4-normal-butyl phenol and propionic acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; 3-n-pro-pyl phenol and butyric acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; 4-normal-butyl phenol and butyric acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; 2-sec-butyl phenol and 2-(4-methyl cyclohexane-3-thiazolinyl) propane-1-alcohol of the weight ratio test with 1/0.025 to 1/250; 4-amyl phenol and 2-(4-methyl cyclohexane-3-thiazolinyl) propane-1-alcohol of the weight ratio test with 1/0.025 to 1/250; 2-sec-butyl phenol and 2,4,6-trimethyl-3-cyclohexene-1-methyl alcohol of the weight ratio test with 1/0.025 to 1/400; 2-TBP and 3,7-dimethyl-octa-1 of the weight ratio test with 1/0.025 to 1/350,6-dien-3-ols; 2-sec-butyl phenol and 3,7-dimethyl-octa-1 of the weight ratio test with 1/0.025 to 1/350,6-dien-3-ols; 4-sec-butyl phenol and 3,7-dimethyl-octa-1 of the weight ratio test with 1/0.025 to 1/350,6-dien-3-ols; 4-sec-butyl phenol and (E)-3 of the weight ratio test with 1/0.025 to 1/300,7-dimethyl-octa-2,6-diene-1-alcohol; 4-chloro-2-isopropyl-5-methylphenol and 5-methyl-2-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; 4-chloro-2-isopropyl-5-methylphenol and 2-methyl-5-(third-1-alkene-2-yl) hexamethylene-2-enol of the weight ratio test with 1/0.025 to 1/450; 4-chloro-2-isopropyl-5-methylphenol and 2-(4-methyl cyclohexane-3-thiazolinyl) propane-1-alcohol of the weight ratio test with 1/0.025 to 1/250; 4-chloro-2-isopropyl-5-methylphenol of the weight ratio test with 1/0.025 to 1/250 and (4S)-(4-(third-1-alkene-2-yl) hexamethylene-1-thiazolinyl) methyl alcohol; 4-chloro-2-isopropyl-5-methylphenol and 2,4,6-trimethyl-3-cyclohexene-1-methyl alcohol of the weight ratio test with 1/0.025 to 1/400; 4-chloro-2-isopropyl-5-methylphenol and 3,7-dimethyl-octa-1 of the weight ratio test with 1/0.025 to 1/250,6-dien-3-ols; 4-chloro-2-isopropyl-5-methylphenol and (E)-3 of the weight ratio test with 1/0.025 to 1/250,7-dimethyl-octa-2,6-diene-1-alcohol; With 4-chloro-2-isopropyl-5-methylphenol of 1/0.025 to 1/350 weight ratio test and cis-3,7-dimethyl-2,6-octadiene-1-alcohol; 2-hydroxy diphenyl methane and 2-((1s, 4r)-4-propyl group cyclohexyl) propane-1 of the weight ratio test with 1/0.025 to 1/1100,3-glycol; 2-hydroxy diphenyl methane and acetic acid (1S, 2S, 5R)-2-isopropyl-5-methyl cyclohexyl of the weight ratio test with 1/0.025 to 1/1100; 2-hydroxy diphenyl methane and propionic acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; 2-hydroxy diphenyl methane and butyric acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester of the weight ratio test with 1/0.025 to 1/1100; The 4-hydroxy diphenyl methane of the weight ratio test with 1/0.025 to 1/400 and (4S)-(4-(third-1-alkene-2-yl) hexamethylene-1-thiazolinyl) methyl alcohol; 5,6,7 of weight ratio test with 1/0.025 to 1/1100,8-tetrahydronaphthalene-1-phenol and acetic acid (1S, 2S, 5R)-2-isopropyl-5-methyl cyclohexyl; 5,6,7 of weight ratio test with 1/0.025 to 1/1100,8-tetrahydro Betanaphthol and acetic acid (1S, 2S, 5R)-2-isopropyl-5-methyl cyclohexyl; 5,6,7 of weight ratio test with 1/0.025 to 1/1100,8-tetrahydronaphthalene-1-phenol and propionic acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester; 5,6,7 of weight ratio test with 1/0.025 to 1/1100,8-tetrahydro Betanaphthol and propionic acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester; 5,6,7 of weight ratio test with 1/0.025 to 1/1100,8-tetrahydronaphthalene-1-phenol and butyric acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester; 5,6,7 of weight ratio test with 1/0.025 to 1/1100,8-tetrahydro Betanaphthol and butyric acid 2-(4-methyl cyclohexane-3-thiazolinyl) propane-2-ester; 2-cyclopenta phenol and 2-methyl-5-(third-1-alkene-2-yl) cyclohexanol of the weight ratio test with 1/0.025 to 1/350; With the 4-amyl phenol of weight ratio test with 1/0.025 to 1/250 and (4S)-(4-(third-1-alkene-2-yl) hexamethylene-1-thiazolinyl) methyl alcohol.
Employing synergistic two claimed class activating agents in antimicrobial acivity is provided carry out further experiment.The adopted name using provides as follows:
3,7-dimethyl-octa-1,6-dien-3-ols: linalool
(E)-3,7-dimethyl-octa-2,6-diene-1-alcohol: geraniol
Cis-3,7-dimethyl-2,6-octadiene-1-alcohol: nerol
5-isopropyl-2-methylphenol: carvacrol.
experimental technique
For representative malignant bacteria organism Gram-negative Escherichia coli test antimicrobial efficacy.The concentration of activating agent represents with the form of weight/volume percent (%w/v) in whole following examples.
Also for representative Gram-positive staphylococcus aureus test selected materials.
escherichia coli bacterium stores thing
The overnight culture preparation of Escherichia coli (10536 bacterial strain), in the TSB liquid nutrient medium of 50 ml cumulative volumes, 37 ℃ of growths approximately 18 hours, and is vibrated at 150 rpm.The 1 ml culture of Escherichia coli of should spending the night is transferred to the fresh TSB liquid nutrient medium of 50 ml and hatches approximately 4 hours with 150rpm at 37 ℃.This culture is divided into equal-volume and with 4000 rpm centrifugal 15 minutes, with Sterile Saline (0.85% NaCl) washing, more once centrifugal, and be resuspended in salt solution, to obtain equaling approximately 10 for this concrete organism
80.8 OD of individual cells/ml
620final concentration.Herein, OD
620show the absorbance at wavelength sample in the cuvette of 1.0 cm paths of 620 nm.This bacterium stores thing and is used to measure (in triplicate) for antimicrobial activities.
Staphylococcus aureus bacterium stores thing
The overnight culture of staphylococcus aureus (10788 bacterial strain) is inoculated into tryptose soya agar (TSA) flat board and grows approximately 18 hours at 37 ℃.On (0.85%NaCl) solution of Sterile Saline for culture of staphylococcus aureus and aseptic spreader slave plate, wash down and be suspended in 50ml salt solution.This suspension is separated into equal volume and with 4000rpm centrifugal 15 minutes.Precipitation Eddy diffusion after centrifugal, in salt solution, obtains 0.35 OD
620final concentration, be equivalent to for every milliliter approximately 10 of this specific organism
8individual cell.Here, OD
620in the cuvette of expression 1.0cm path, sample is in the absorbance of 620nm wavelength.This bacterium stores thing and is used to measure antimicrobial acivity (in triplicate).
scheme
Below measure and described the 8 kinds of materials of 6 dilution factor tests that use across half of 96 hole titer plate (MTP).Use the method, can measure 16 kinds of activating agents (not repeating) with a complete dilution plate, at two halves 1-6 and the 7-12 of panel, repeat this setting.
The 1M solution of preparation test agents in methyl-sulfoxide (DMSO).The storage solutions of preparing the activating agent of 1.11 times of required final concentrations by dilute DMSO solution in water, thereby make for example for required " in test " concentration of 0.8% w/v, to prepare 0.89% w/v solution, to allow further to dilute activating agent (being diluted to 300 μ l from 270 μ l) when adding bacterial suspension, as described below.
The aliquot of the material of 1.11 times of final concentrations (270 μ l) is dispensed in the hole of MTP along row (A1-H1).This MTP is labeled as " screen plate ".
At another, be labeled as in the MTP of " dilution plate ", the 270 μ l D/E neutralization solutions from DIFCO composition are added into the 1st row.Neutralization solution composed as follows: caseic trypsinization thing, 5.0g/L; Yeast extract, 2.5 g/L; Dextrose, 10 g/L, sodium thioglycolate, 1.0 g/L, sodium thiosulfate, 6.0 g/L; Sodium hydrogensulfite, 2.5 g/L; Polyoxyethylene sorbitan monoleate, 5.0 g/L; Lecithin 7.0 g/L; Bromocresol purple, 0.02 g/L, pH value scope is 7.6 ± 0.2.
270 μ l tryptone dilute solutions are added into all residues hole (2-6 row) of dilution MTP.
Then bacterium is stored to thing (30 μ l) and be added into the 270 μ l activator solutions of preparing in screen plate, and use the Multi-channel liquid transfer device with 8 suction nozzles to mix to aspirate and the bacterium of same volume is stored in 8 holes that thing dispensed in parallel to the A-H is capable.After the time of contact of 15 seconds, by use, aspirate to mix the mixture of 30 μ l volumes is transferred in 270 μ l D/E neutralization solutions in the dilution plate of preparation and cancellation mixture.In D/E neutralization solution, after lucky 5 minutes, 30 μ l volumes be listed as and mixed from the 1st column jump to the 2 of dilution MTP, then further 30 μ l volumes being listed as from the 2nd column jump to the 3.By bacterium being crossed over to plate serial dilution to the 6 row, repeat this process.
The 30 μ l volumes in each hole from dilution MTP are transferred on tryptose soya agar (TSA) plate to the section of mark in advance, from minimum bacterial concentration (high dilution, the 6th row), start to the highest bacterial concentration (the 1st row).Make TSA culture plate place approximately 2 hours, thereby 30 μ l vaccinations can be dried, then plate is put upside down and 37 ℃ of overnight incubation, then the dilution factor with mark calculates bacterial clump, to determine the impact of activating agent on bacterial growth.
result of calculation
By first determining that wherein the number of bacterial clump is that computable TSA plate section obtains average bacteria living and counts N
mBS(with Log CFU/ml, representing).Clump count from this section, calculates N by following formula
mBS:
N
MBS?=?log{?N
col?·?10
DF?·?100?/?3?}
Herein, N
colfor colony counting, DF be the dilution gfactor corresponding to TSA plate section of taking from MTP hole (that is, the scope of DF can from cancellation 1 to high dilution 6).The factor 100/3 is the transforming factor from vaccination volume to 1 milliliter.
Carry out in triplicate each determination test.The average bacteria living result of report is this type of in triplicate mean value, and error is corresponding standard deviation.
Therefore, approximately 7 N
mBSvalue is corresponding to the counting of approximately 3 bacterium colonies from the 5th dilution holes (being DF=5).
When bacterial exposure is during in non-biocidal material, conventionally observe this type of counting of approximately 7.In the situation that do not observe any survival bacterium colony in any section of TSA plate, this is interpreted as killing completely and reporting N
mBS=0 value.
Escherichia coli in data relative model surfactant
The method of testing of the automation of effect assessment in surfactant base-material
the microbiocidal activity of activating agent according to the present invention in model surface activating agent medium
the method of testing of the automation of effect assessment in surfactant base-material
In these embodiments, the effect of activating agent combination is tested in the surfactant cleaning formulation that comprises 2.85% cocoyl Sodium Glycinate and 1.85 % bay both sexes guanidine-acetic acid sodium.
The use dilution that this dilutes corresponding to the water 50% that contains the not water mixing preparation (neat formulation) of 5.7% cocoyl glycinate and 3.7% bay both sexes guanidine-acetic acid sodium in the process of washing one's hands.
Prepare solution, thereby 1.1 times of making that the concentration of surface active agent composition and test agents is final desired concn dilute in test allowing with bacterial inoculum.By solution by dropwise adding sodium hydroxide solution manual adjustment to pH 10.0, as environmental temperature with pH meter measured.
At approximately 1 x 10
8the concentration of individual bacterium/mL, measures for Escherichia coli (Escherichia coli-ATCC #10536) effect that the present invention combines.
Use standard microtiter plate determination method is used automated fluid treatment system to test.270 μ l surfactant test solutions are moved to liquid to each hole of microtiter plate, then add 30 μ l bacterial suspensions.After lucky 15 seconds of bacterial exposure, the bacterial cell of 30 μ l volumes is taken out and is transferred to 270 μ l D/E cancellation solution.In D/E cancellation solution, after 5 minutes, at two specific wavelengths (450nm and 590nm), for each plate, measure optical density (OD) successively.These provide the duplication check of antimicrobial acivity because when observing bacterial growth OD
450reading is specific for the yellow of D/E cancellation, and if do not observe bacterial growth, OD
590initial purple for the D/E cancellation retaining is specific.After time zero OD measures, then by plate in 37 ℃ of overnight incubation (16 hours), then repeat OD and measure.Initial value when from time zero deducts the OD value of 16 hours and calculates Δ OD value.Bacterial growth is observed to OD
450increase and OD
590reduction.In order to identify antibacterial upper efficient system (preventing from hatching the system of rear appreciable bacterial growth), adopted the changes of threshold of following OD reading: if (1). hatch rear OD
450increase and be less than 0.2 absorbance unit and (2). hatch rear OD
590reduce and be less than 0.35 unit.On the contrary, OD after hatching
450increase and surpass 0.2 AU and OD
590reduce while surpassing 0.35 unit, corresponding to color, from purple, move to yellow, test macro allows bacterial growth and can not be regarded as effectively.For each test macro, four duplicate measurements in same plate, have been carried out.The number of the repeating hole that shows bacterial growth or do not grow is also easily assessed by eyes by following change color.
By with further surfactant solution successively diluent liquid to obtain a series of end points and generate the single component of activating agent and with the dose response of the binary mixture of fixed concentration ratio.
In each case, with the phenol of 1:2.5, than the weight by weight ratio of terpene alcohol, assess binary mixture.In some selected situations, also with weight ratio 1:1 test combination.
Data are summarised in following table.In model surface activator solution separately and the phenol of combination and antimicrobial alcohol for colibacillary antibacterial activity
table 33
In model surface activator solution phenolic compound and antimicrobial alcohol separately and combination for colibacillary antibacterial activity
table 34
The minimum substrate concentration of killing livestock of the antimicrobial components in the 2.85% cocoyl Sodium Glycinate+1.85% bay both sexes guanidine-acetic acid sodium solution of pH10
| Composition | MBC (% w/v) |
| (+/-)-linalool | > 0.5 |
| Geraniol | > 0.5 |
| Nerol | > 0.5 |
| Carvacrol | > 0.2 |
| 4-isopropyl-3-methylphenol | > 0.2 |
| The 2-tert-butyl group-5-methylphenol | 0.2 |
| (E)-2-(third-1-thiazolinyl) phenol | > 0.2 |
| 2-propylphenol | 0.175 |
| 3-propylphenol | > 0.2 |
| 4-propylphenol | > 0.2 |
| 2-TBP | 0.2 |
| 3-tert-butyl phenol | > 0.2 |
| 2-sec-butyl phenol | 0.175 |
| 4-sec-butyl phenol | > 0.2 |
table 35
For the composition of killing bacteria completely, the degree of the cooperative interaction between binary compound mixture are provided for Escherichia coli
While testing in containing surfactant medium, other binary combination shows the effect that each component of same concentrations is strengthened, but can not prove synergy.
Staphylococcus aureus in the relative water of data
table 36
2-propylphenol individually and with the antibacterial activity for staphylococcus aureus of geraniol combination
| Phenolic compound concentration (% w/v) | The concentration of antimicrobial alcohol (%w/v) | N MBS[log CFU/ml] | Standard deviation |
| 0.5% 2-propylphenol | 0 | 0 | 0 |
| 0.25% 2-propylphenol | 0 | 4.12 | 0.11 |
| 0.125% 2-propylphenol | 0 | 7.06 | 0.14 |
| 0.05% 2-propylphenol | 0 | 7.40 | 0.35 |
| 0 | 1.5% geraniol | 7.14 | 0.15 |
| 0 | 1.0% geraniol | 7.18 | 0.10 |
| 0 | 0.75% geraniol | 7.16 | 0.06 |
| 0 | 0.5% geraniol | 7.43 | 0.12 |
| 0.25% 2-propylphenol | 0.5% geraniol | 0 | 0 |
table 37
Antimicrobial composition is for the minimum substrate concentration of killing livestock of staphylococcus aureus
| Composition | MBC (% w/v) |
| 2-propylphenol | 0.5 |
| Geraniol | > 1.5 |
table 38
For the composition of killing bacteria completely, the degree of the cooperative interaction between binary compound mixture are provided for staphylococcus aureus
in water, activating agent is for the antimicrobial efficacy of staphylococcus aureus
Staphylococcus aureus bacterium stores thing and shows as follows preparation, and the antimicrobial efficacy of activating agent is explained and carries out for Escherichia coli as front.
The overnight culture of staphylococcus aureus (10788 bacterial strain) is inoculated on trypticase soy agar (TSA) plate and 37 ℃ of growths approximately 18 hours.Use Sterile Saline (0.85% NaCl) solution and aseptic spreader slave plate to wash and be suspended in 50ml salt solution the culture of staphylococcus aureus.This suspension is divided into equal-volume and with 4000 rpm centrifugal 15 minutes.After centrifugal, by pellet resuspended in salt solution, to obtain equaling approximately 10 for this concrete organism
80.35 OD of individual cells/ml
620final concentration.Herein, OD
620show the absorbance at wavelength sample in the cuvette of 1.0 cm paths of 620 nm.This bacterium stores thing and is used to measure (in triplicate) for antimicrobial activities.
table 39
According to the antibacterial activity that the present invention is directed to some combination of staphylococcus aureus, be summarized as follows:
Claims (11)
1. synergistic microbicidal compositions, it comprises: (a) be selected from 3,7-dimethyl-octa-1,6-dien-3-ols, (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol, and cis-3,7-dimethyl-2, at least one microbicide of 6-octadiene-1-alcohol; (b) be selected from least one microbicide of 5-isopropyl-2-methylphenol, 3-isopropyl-5-methylphenol, 4-isopropyl-3-methylphenol, (E)-2-(third-1-thiazolinyl) phenol, 4-propylphenol, 2-TBP, 2-sec-butyl phenol, 2-n-pro-pyl phenol, 3-n-pro-pyl phenol, 4-normal-butyl phenol, 4-sec-butyl phenol and 3-tert-butyl phenol.
2. the synergistic microbicidal compositions of claim 1, it comprises and is selected from (a) 3,7-dimethyl-octa-1,6-dien-3-ols (linalool), (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol (geraniol) and cis-3,7-dimethyl-2, at least one microbicide of 6-octadiene-1-alcohol (nerol) and (b) be selected from least one microbicide of 2-n-pro-pyl phenol, 4-normal-butyl phenol and 4-sec-butyl phenol.
3. the synergistic microbicidal compositions of claim 1, it comprises: (a) 3,7-dimethyl-octa-1,6-dien-3-ols; (b) be selected from least one microbicide of 5-isopropyl-2-methylphenol, 4-isopropyl-3-methylphenol, (E)-2-(third-1-thiazolinyl) phenol, 4-propylphenol, 2-n-pro-pyl phenol, 3-n-pro-pyl phenol, 4-normal-butyl phenol and 3-tert-butyl phenol.
4. the synergistic microbicidal compositions of claim 3, 5-isopropyl-2-methylphenol and 3 wherein, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.4-1/3.1, 4-isopropyl-3-methylphenol and 3, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is from 1/0.05-1/2.5, (E)-2-(third-1-thiazolinyl) phenol and 3, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.04-1/2.5, 4-propylphenol and 3, 7-dimethyl-octa-1, the weight ratio 1/0.38-1/3.1 of 6-dien-3-ols, 2-n-pro-pyl phenol and 3, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.1-1/2.5, 3-n-pro-pyl phenol and 3, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.13-1/4.2, 4-normal-butyl phenol and 3, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.5-1/3.1 and 3-tert-butyl phenol and 3, 7-dimethyl-octa-1, the weight ratio of 6-dien-3-ols is 1/0.13-1/4.2.
5. the synergistic microbicidal compositions of claim 1, it comprises: (a) (E)-3,7-dimethyl-octa-2,6-diene-1-alcohol; (b) be selected from least one microbicide of 5-isopropyl-2-methylphenol, 3-isopropyl-5-methylphenol, 4-isopropyl-3-methylphenol, (E)-2-(third-1-thiazolinyl) phenol, 4-propylphenol, 2-TBP, 2-sec-butyl phenol, 2-n-pro-pyl phenol, 3-n-pro-pyl phenol and 4-normal-butyl phenol.
6. the synergistic microbicidal compositions of claim 5, 5-isopropyl-2-methylphenol and (E)-3 wherein, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.05-1/33, 3-isopropyl-5-methylphenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.08-1/20, 4-isopropyl-3-methylphenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/1-1/2.4, (E)-2-(third-1-thiazolinyl) phenol and (E)-3, 7-dimethyl-octa-2, the weight ratio 1/0.03-1/6.7 of 6-diene-1-alcohol, 4-propylphenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.25-1/33, 2-TBP and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.5-1/8, 2-sec-butyl phenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/2-1/16, 2-n-pro-pyl phenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.4 to 1/20, 3-n-pro-pyl phenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.06 to 1/33, and 4-normal-butyl phenol and (E)-3, 7-dimethyl-octa-2, the weight ratio of 6-diene-1-alcohol is 1/0.25 to 1/25.
7. the synergistic microbicidal compositions of claim 1, it comprises: (a) cis-3,7-dimethyl-2,6-octadiene-1-alcohol; (b) be selected from 5-isopropyl-2-methylphenol; At least one microbicide of 3-isopropyl-5-methylphenol, 4-isopropyl-3-methylphenol, (E)-2-(third-1-thiazolinyl) phenol, 4-propylphenol, 2-TBP, 2-sec-butyl phenol, 2-n-pro-pyl phenol, 3-n-pro-pyl phenol, 4-normal-butyl phenol, 4-sec-butyl phenol and 3-tert-butyl phenol.
8. the synergistic microbicidal compositions of claim 7, wherein 5-isopropyl-2-methylphenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.08-1/0.5, 3-isopropyl-5-methylphenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.06-1/0.38, 4-isopropyl-3-methylphenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.13-1/0.38, (E)-2-(third-1-thiazolinyl) phenol and cis-3, 7-dimethyl-2, the weight ratio 1/0.04-1/0.33 of 6-octadiene-1-alcohol, 4-propylphenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.08-1/5, 2-TBP and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/3.3-1/6.7, 2-sec-butyl phenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/5-1/150, 2-n-pro-pyl phenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.13 to 1/2.5, 3-n-pro-pyl phenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.06 to 1/3.3, and 4-normal-butyl phenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.25 to 1/3.3, 4-sec-butyl phenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/1-1/3.3 and 3-tert-butyl phenol and cis-3, 7-dimethyl-2, the weight ratio of 6-octadiene-1-alcohol is 1/0.13 to 1/6.7.
9. according to synergistic microbicidal compositions in any one of the preceding claims wherein, one or more surfactants that it comprises 1-80% by weight.
10. according to the synergistic microbicidal compositions of claim 9, wherein said one or more surfactants are selected from soap class, alkyl sulfate and linear alkylbenzene sulfonate (LAS).
The method of 11. surface sterilizations, it comprises step:
A. will be applied to described surface according to the composition of aforementioned arbitrary claim, and
B. by composition from surface removal.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567360P | 2011-12-06 | 2011-12-06 | |
| US61/567,360 | 2011-12-06 | ||
| US61/567360 | 2011-12-06 | ||
| US201261664772P | 2012-06-27 | 2012-06-27 | |
| US61/664,772 | 2012-06-27 | ||
| US61/664772 | 2012-06-27 | ||
| PCT/EP2012/074401 WO2013083580A1 (en) | 2011-12-06 | 2012-12-05 | Microbicidal composition |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103957704A true CN103957704A (en) | 2014-07-30 |
| CN103957704B CN103957704B (en) | 2016-08-31 |
Family
ID=47278853
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201280060222.1A Active CN103957704B (en) | 2011-12-06 | 2012-12-05 | Synergistic microbicidal compositions |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20150087723A1 (en) |
| EP (1) | EP2787817B1 (en) |
| JP (1) | JP2015500815A (en) |
| CN (1) | CN103957704B (en) |
| BR (1) | BR112014013612B1 (en) |
| EA (1) | EA026260B1 (en) |
| IN (1) | IN2014MN01035A (en) |
| MX (1) | MX363488B (en) |
| WO (1) | WO2013083580A1 (en) |
| ZA (1) | ZA201403744B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6130854B2 (en) * | 2011-12-06 | 2017-05-17 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Antibacterial composition |
| JP2023514396A (en) * | 2020-02-21 | 2023-04-05 | フイルメニツヒ ソシエテ アノニム | antibacterial composition |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071998C (en) * | 1996-07-16 | 2001-10-03 | 普罗格特-甘布尔公司 | Use of combination of surfactants, chelating agents and essential oils for effective disinfection |
| US20070231295A1 (en) * | 2004-05-12 | 2007-10-04 | Holger Hoppe | Antimicrobial Silicon Oxide Flakes |
| WO2008035101A2 (en) * | 2006-09-21 | 2008-03-27 | Mainsani As | Disinfectant emulsions containing an antimicrobial compound in each phase |
| US8066979B1 (en) * | 2007-07-13 | 2011-11-29 | The United States Of America As Represented By The Secretary Of Agriculture | Attractants and repellents for the tropical root weevil Diaprepes Abbreviatus |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US28263A (en) * | 1860-05-15 | Improved insulator for electrodes | ||
| JPS61118301A (en) * | 1984-11-14 | 1986-06-05 | Mitsui Petrochem Ind Ltd | Aqueous dispersion type antibacterial and antifungal pharmaceutical composition |
| JPH0267202A (en) * | 1988-09-01 | 1990-03-07 | Takara Kosan Kk | Mothproofing molded product |
| US5444078A (en) | 1993-10-01 | 1995-08-22 | Rohm And Haas Company | Fully water-dilutable microemulsions |
| JPH08277371A (en) * | 1995-02-09 | 1996-10-22 | Kanebo Kasei Kk | Antibacterial and antifungal coating composition |
| DE69627208T3 (en) * | 1996-07-16 | 2011-08-18 | The Procter & Gamble Co., Ohio | USE OF A MIXTURE CONTAINING EMULSIFICATORS, COMPLEX FILTERS AND ETHERIC OILS AS DISINFECTANTS |
| US5965518A (en) * | 1998-02-23 | 1999-10-12 | Nakatsu; Tetsuo | Fragrance compositions having antimicrobial activity |
| US6482423B1 (en) * | 1999-04-13 | 2002-11-19 | The Procter & Gamble Company | Antimicrobial wipes which provide improved residual benefit versus gram positive bacteria |
| JP2005015684A (en) | 2003-06-27 | 2005-01-20 | Kiyomitsu Kawasaki | Method for preparing vegetable flavor |
| JP2005013138A (en) | 2003-06-27 | 2005-01-20 | Kiyomitsu Kawasaki | Method for producing spice flavor |
| US20080253976A1 (en) | 2007-04-16 | 2008-10-16 | Douglas Craig Scott | Personal Care Compositions Comprising An Antimicrobial Blend of Essential Oils or Constituents Thereof |
| AU2009306592B2 (en) | 2008-10-20 | 2013-05-23 | Unilever Global Ip Limited | An antimicrobial composition |
| GB0905863D0 (en) | 2009-04-03 | 2009-05-20 | Glaxo Group Ltd | Novel composition |
| CN102113523A (en) | 2009-12-30 | 2011-07-06 | 源达日化(天津)有限公司 | High-efficiency mothproofing agent |
| JP5804307B2 (en) * | 2010-03-03 | 2015-11-04 | サンスター株式会社 | Oral composition |
| EP2595642A2 (en) | 2010-07-19 | 2013-05-29 | The Procter and Gamble Company | Compositions comprising derivatives of essential oil compounds and use in personal care products |
-
2012
- 2012-12-05 BR BR112014013612-2A patent/BR112014013612B1/en active IP Right Grant
- 2012-12-05 MX MX2014006830A patent/MX363488B/en unknown
- 2012-12-05 WO PCT/EP2012/074401 patent/WO2013083580A1/en active Application Filing
- 2012-12-05 IN IN1035MUN2014 patent/IN2014MN01035A/en unknown
- 2012-12-05 JP JP2014545212A patent/JP2015500815A/en active Pending
- 2012-12-05 CN CN201280060222.1A patent/CN103957704B/en active Active
- 2012-12-05 EA EA201400657A patent/EA026260B1/en not_active IP Right Cessation
- 2012-12-05 US US14/363,452 patent/US20150087723A1/en not_active Abandoned
- 2012-12-05 EP EP12794984.0A patent/EP2787817B1/en active Active
-
2014
- 2014-05-22 ZA ZA2014/03744A patent/ZA201403744B/en unknown
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1071998C (en) * | 1996-07-16 | 2001-10-03 | 普罗格特-甘布尔公司 | Use of combination of surfactants, chelating agents and essential oils for effective disinfection |
| US20070231295A1 (en) * | 2004-05-12 | 2007-10-04 | Holger Hoppe | Antimicrobial Silicon Oxide Flakes |
| WO2008035101A2 (en) * | 2006-09-21 | 2008-03-27 | Mainsani As | Disinfectant emulsions containing an antimicrobial compound in each phase |
| US8066979B1 (en) * | 2007-07-13 | 2011-11-29 | The United States Of America As Represented By The Secretary Of Agriculture | Attractants and repellents for the tropical root weevil Diaprepes Abbreviatus |
Non-Patent Citations (1)
| Title |
|---|
| GILLES FIGUÉRÉDO 等: "Studies of Mediterranean oregano populations.VIII—Chemical composition of essential oils of oreganos of various origins", 《FLAVOUR AND FRAGRANCE JOURNAL》, vol. 21, 31 December 2006 (2006-12-31), XP055036573, DOI: doi:10.1002/ffj.1543 * |
Also Published As
| Publication number | Publication date |
|---|---|
| MX2014006830A (en) | 2015-02-12 |
| EA201400657A1 (en) | 2014-11-28 |
| EP2787817A1 (en) | 2014-10-15 |
| CN103957704B (en) | 2016-08-31 |
| ZA201403744B (en) | 2016-12-21 |
| BR112014013612A2 (en) | 2017-06-13 |
| US20150087723A1 (en) | 2015-03-26 |
| BR112014013612B1 (en) | 2020-11-17 |
| IN2014MN01035A (en) | 2015-10-02 |
| WO2013083580A1 (en) | 2013-06-13 |
| EA026260B1 (en) | 2017-03-31 |
| EP2787817B1 (en) | 2015-09-30 |
| MX363488B (en) | 2019-03-26 |
| JP2015500815A (en) | 2015-01-08 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN103957715A (en) | Antimicrobial composition | |
| CN104010500B (en) | Synergistic microbicidal compositions | |
| CN104080341A (en) | Antimicrobial composition | |
| CN104023539A (en) | Antimicrobial composition | |
| CN104080343A (en) | Method for disinfecting a surface | |
| CN104010512B (en) | Synergistic microbicidal compositions | |
| CN103957717A (en) | Microbicidal composition | |
| CN104010513B (en) | Synergistic microbicidal compositions | |
| CN103957704A (en) | Microbicidal composition | |
| JP6040257B2 (en) | Disinfectant composition | |
| CN104093315B (en) | Antimicrobial compositions | |
| CN104080342B (en) | Antimicrobial compositions | |
| CN104378988A (en) | Antimicrobial composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20210824 Address after: Rotterdam Patentee after: Unilever Intellectual Property Holdings Ltd. Address before: Rotterdam Patentee before: Netherlands Unilever Co.,Ltd. |
|
| TR01 | Transfer of patent right |